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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:TMEM234-CSMD2 (FusionGDB2 ID:91947) |
Fusion Gene Summary for TMEM234-CSMD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM234-CSMD2 | Fusion gene ID: 91947 | Hgene | Tgene | Gene symbol | TMEM234 | CSMD2 | Gene ID | 56063 | 114784 |
| Gene name | transmembrane protein 234 | CUB and Sushi multiple domains 2 | |
| Synonyms | AASL548|C1orf91|PRO1105|RP4-622L5|dJ622L5.7 | dJ1007G16.1|dJ1007G16.2|dJ947L8.1 | |
| Cytomap | 1p35.2 | 1p35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 234 | CUB and sushi domain-containing protein 2CUB and Sushi (SCR repeat) domainCUB and sushi multiple domains protein 2 | |
| Modification date | 20200320 | 20200313 | |
| UniProtAcc | . | Q7Z408 | |
| Ensembl transtripts involved in fusion gene | ENST00000309777, ENST00000344461, ENST00000545122, ENST00000485689, ENST00000373593, | ENST00000338325, ENST00000373377, ENST00000373380, ENST00000373388, ENST00000489419, ENST00000373381, | |
| Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 13 X 12 X 7=1092 |
| # samples | 5 | 14 | |
| ** MAII score | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/1092*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM234 [Title/Abstract] AND CSMD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | TMEM234(32682860)-CSMD2(34258127), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across TMEM234 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CSMD2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-02-2486-01A | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
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Fusion Gene ORF analysis for TMEM234-CSMD2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000309777 | ENST00000338325 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5CDS-intron | ENST00000309777 | ENST00000373377 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5CDS-intron | ENST00000309777 | ENST00000373380 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5CDS-intron | ENST00000309777 | ENST00000373388 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5CDS-intron | ENST00000309777 | ENST00000489419 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5CDS-intron | ENST00000344461 | ENST00000338325 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5CDS-intron | ENST00000344461 | ENST00000373377 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5CDS-intron | ENST00000344461 | ENST00000373380 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5CDS-intron | ENST00000344461 | ENST00000373388 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5CDS-intron | ENST00000344461 | ENST00000489419 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5CDS-intron | ENST00000545122 | ENST00000338325 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5CDS-intron | ENST00000545122 | ENST00000373377 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5CDS-intron | ENST00000545122 | ENST00000373380 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5CDS-intron | ENST00000545122 | ENST00000373388 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5CDS-intron | ENST00000545122 | ENST00000489419 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5UTR-3CDS | ENST00000485689 | ENST00000373381 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5UTR-intron | ENST00000485689 | ENST00000338325 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5UTR-intron | ENST00000485689 | ENST00000373377 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5UTR-intron | ENST00000485689 | ENST00000373380 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5UTR-intron | ENST00000485689 | ENST00000373388 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| 5UTR-intron | ENST00000485689 | ENST00000489419 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| Frame-shift | ENST00000309777 | ENST00000373381 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| Frame-shift | ENST00000344461 | ENST00000373381 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| In-frame | ENST00000545122 | ENST00000373381 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| intron-3CDS | ENST00000373593 | ENST00000373381 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| intron-intron | ENST00000373593 | ENST00000338325 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| intron-intron | ENST00000373593 | ENST00000373377 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| intron-intron | ENST00000373593 | ENST00000373380 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| intron-intron | ENST00000373593 | ENST00000373388 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| intron-intron | ENST00000373593 | ENST00000489419 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000545122 | TMEM234 | chr1 | 32682860 | - | ENST00000373381 | CSMD2 | chr1 | 34258127 | - | 12438 | 377 | 338 | 9826 | 3162 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000545122 | ENST00000373381 | TMEM234 | chr1 | 32682860 | - | CSMD2 | chr1 | 34258127 | - | 0.001698315 | 0.9983016 |
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Fusion Genomic Features for TMEM234-CSMD2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TMEM234-CSMD2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:32682860/chr1:34258127) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | CSMD2 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TMEM234 | chr1:32682860 | chr1:34258127 | ENST00000309777 | - | 4 | 5 | 1_21 | 109 | 141.0 | Transmembrane | Helical |
| Hgene | TMEM234 | chr1:32682860 | chr1:34258127 | ENST00000309777 | - | 4 | 5 | 82_102 | 109 | 141.0 | Transmembrane | Helical |
| Hgene | TMEM234 | chr1:32682860 | chr1:34258127 | ENST00000344461 | - | 4 | 6 | 1_21 | 109 | 165.0 | Transmembrane | Helical |
| Hgene | TMEM234 | chr1:32682860 | chr1:34258127 | ENST00000344461 | - | 4 | 6 | 82_102 | 109 | 165.0 | Transmembrane | Helical |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 1037_1096 | 0 | 1168.0 | Domain | Sushi 6 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 1098_1206 | 0 | 1168.0 | Domain | CUB 7 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 1209_1269 | 0 | 1168.0 | Domain | Sushi 7 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 1271_1380 | 0 | 1168.0 | Domain | CUB 8 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 137_198 | 0 | 1168.0 | Domain | Sushi 1 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 1383_1443 | 0 | 1168.0 | Domain | Sushi 8 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 1445_1553 | 0 | 1168.0 | Domain | CUB 9 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 1556_1617 | 0 | 1168.0 | Domain | Sushi 9 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 1619_1727 | 0 | 1168.0 | Domain | CUB 10 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 1733_1794 | 0 | 1168.0 | Domain | Sushi 10 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 1796_1904 | 0 | 1168.0 | Domain | CUB 11 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 1907_1966 | 0 | 1168.0 | Domain | Sushi 11 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 1968_2076 | 0 | 1168.0 | Domain | CUB 12 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 202_306 | 0 | 1168.0 | Domain | CUB 2 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 2121_2180 | 0 | 1168.0 | Domain | Sushi 12 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 2182_2293 | 0 | 1168.0 | Domain | CUB 13 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 2292_2353 | 0 | 1168.0 | Domain | Sushi 13 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 2355_2466 | 0 | 1168.0 | Domain | CUB 14 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 2466_2528 | 0 | 1168.0 | Domain | Sushi 14 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 2529_2590 | 0 | 1168.0 | Domain | Sushi 15 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 2591_2655 | 0 | 1168.0 | Domain | Sushi 16 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 2656_2713 | 0 | 1168.0 | Domain | Sushi 17 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 26_134 | 0 | 1168.0 | Domain | CUB 1 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 2714_2771 | 0 | 1168.0 | Domain | Sushi 18 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 2772_2829 | 0 | 1168.0 | Domain | Sushi 19 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 2833_2890 | 0 | 1168.0 | Domain | Sushi 20 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 2891_2949 | 0 | 1168.0 | Domain | Sushi 21 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 2950_3009 | 0 | 1168.0 | Domain | Sushi 22 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 3010_3067 | 0 | 1168.0 | Domain | Sushi 23 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 3068_3125 | 0 | 1168.0 | Domain | Sushi 24 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 3129_3187 | 0 | 1168.0 | Domain | Sushi 25 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 3188_3247 | 0 | 1168.0 | Domain | Sushi 26 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 341_402 | 0 | 1168.0 | Domain | Sushi 2 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 405_516 | 0 | 1168.0 | Domain | CUB 3 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 519_576 | 0 | 1168.0 | Domain | Sushi 3 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 578_686 | 0 | 1168.0 | Domain | CUB 4 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 689_750 | 0 | 1168.0 | Domain | Sushi 4 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 752_860 | 0 | 1168.0 | Domain | CUB 5 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 865_922 | 0 | 1168.0 | Domain | Sushi 5 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 924_1034 | 0 | 1168.0 | Domain | CUB 6 | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 1_3408 | 0 | 1168.0 | Topological domain | Extracellular | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 3430_3487 | 0 | 1168.0 | Topological domain | Cytoplasmic | |
| Tgene | CSMD2 | chr1:32682860 | chr1:34258127 | ENST00000373380 | 0 | 24 | 3409_3429 | 0 | 1168.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TMEM234 | chr1:32682860 | chr1:34258127 | ENST00000309777 | - | 4 | 5 | 112_132 | 109 | 141.0 | Transmembrane | Helical |
| Hgene | TMEM234 | chr1:32682860 | chr1:34258127 | ENST00000344461 | - | 4 | 6 | 112_132 | 109 | 165.0 | Transmembrane | Helical |
| Hgene | TMEM234 | chr1:32682860 | chr1:34258127 | ENST00000373593 | - | 1 | 4 | 112_132 | 0 | 181.0 | Transmembrane | Helical |
| Hgene | TMEM234 | chr1:32682860 | chr1:34258127 | ENST00000373593 | - | 1 | 4 | 1_21 | 0 | 181.0 | Transmembrane | Helical |
| Hgene | TMEM234 | chr1:32682860 | chr1:34258127 | ENST00000373593 | - | 1 | 4 | 82_102 | 0 | 181.0 | Transmembrane | Helical |
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Fusion Gene Sequence for TMEM234-CSMD2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >91947_91947_1_TMEM234-CSMD2_TMEM234_chr1_32682860_ENST00000545122_CSMD2_chr1_34258127_ENST00000373381_length(transcript)=12438nt_BP=377nt ATGGGTCTCCGCCCCTTCGTTCCCGGAAGTAGAAGACAGCGGCGTTGCCATGGCGGCGTCTCTGGGGCAGGTGTTGGCTCTGGTGCTGGT GGCCGCTCTGTGGGGTGGCACGCAGCCGCTGCTGAAGCGGGCCTCCGCCGGCCTGCAGCGGGTTCATGAGCCGACCTGGGCCCAGCAGTT GCTACAGGAGATGAAGACCCTCTTCTTGAATACTGAGTACCTGATGCCCTTTCTCCTCAACCAGTGTGGATCCCTTCTCTATTACCTCAC CTTGGCATCGACAGATCTGACCCTGGCTGTGCCCATCTGTAACTCTCTGGCTATCATCTTCACACTGATTGTTGGGAAGGCCCTTGGAGA AGATATTGGTGGAAAACGTGATCAAGCTCGCCTTTGAGGAGTTTGATTTGGAGAGGGGCTATGACACCCTGACGGTCGGTGATGGTGGTC AGGATGGGGACCAGAAGACAGTTCTCTACATCCTGACAGGTACATCGGTCCCGGATCTCATTGTCAGCACCAATCATCAAATGTGGCTCC TCTTCCAGACTGATGGCAGTGGCAGTTCCCTGGGATTCAAGGCTTCTTATGAAGAGATCGAGCAGGGCAGTTGCGGTGACCCTGGCATAC CTGCATATGGCCGGAGGGAAGGCTCCCGGTTTCACCACGGTGACACACTCAAGTTTGAGTGCCAGCCCGCCTTTGAGCTGGTGGGACAGA AGGCAATCACATGCCAAAAGAATAACCAATGGTCGGCTAAGAAGCCAGGCTGCGTGTTCTCCTGCTTCTTCAACTTCACCAGCCCGTCTG GGGTTGTCCTGTCTCCCAACTACCCAGAGGACTATGGCAACCACCTCCACTGTGTCTGGCTCATCCTGGCCAGGCCTGAGAGCCGCATCC ACCTGGCCTTCAACGACATTGACGTGGAGCCTCAGTTTGATTTCCTGGTCATCAAGGATGGGGCCACCGCCGAGGCGCCCGTCCTGGGCA CCTTCTCAGGAAACCAGCTTCCCTCCTCCATCACAAGCAGTGGCCACGTGGCCCGTCTCGAGTTCCAGACTGACCACTCCACAGGGAAGA GGGGCTTCAACATCACTTTTACCACCTTCCGACACAACGAGTGCCCGGATCCTGGCGTTCCAGTAAATGGCAAACGGTTTGGGGACAGCC TCCAGCTGGGCAGCTCCATCTCCTTCCTCTGTGATGAAGGCTTCCTTGGGACTCAGGGCTCAGAGACCATCACCTGCGTCCTGAAGGAGG GCAGCGTGGTCTGGAACAGCGCTGTGCTGCGGTGTGAAGCTCCCTGTGGTGGTCACCTGACTTCGCCCAGCGGCACCATCCTCTCTCCGG GCTGGCCTGGCTTCTACAAGGATGCCTTGAGCTGTGCCTGGGTGATTGAGGCCCAGCCAGGCTACCCCATCAAAATCACCTTCGACAGAT TCAAAACCGAGGTCAACTATGACACCCTGGAAGTACGCGATGGGCGGACTTACTCAGCGCCCTTGATCGGGGTTTACCACGGGACCCAGG TTCCCCAGTTCCTCATCAGCACCAGCAACTACCTCTACCTCCTCTTCTCTACCGACAAGAGTCACTCGGACATCGGCTTCCAGCTCCGCT ATGAGACTATAACACTGCAGTCAGACCACTGTCTGGATCCAGGAATCCCAGTAAATGGACAGCGTCATGGGAATGACTTCTACGTGGGCG CGCTGGTGACCTTCAGCTGTGACTCGGGCTACACATTAAGTGACGGGGAGCCTCTGGAGTGTGAGCCCAACTTCCAGTGGAGCCGGGCCC TGCCCAGTTGTGAAGCTCTCTGTGGTGGCTTCATTCAAGGCTCCAGTGGGACCATCTTGTCGCCAGGGTTCCCTGACTTCTACCCCAACA ACTTGAACTGCACCTGGATTATCGAAACATCTCATGGCAAGGGTGTGTTCTTCACTTTCCACACCTTCCACCTGGAAAGTGGCCATGACT ACCTCCTCATCACTGAGAACGGCAGCTTCACCCAGCCCCTGAGGCAGCTAACTGGATCTCGGCTGCCAGCTCCCATCAGCGCTGGGCTCT ATGGCAACTTCACTGCCCAGGTCCGCTTCATCTCTGATTTCTCCATGTCATATGAAGGATTCAACATCACCTTCTCAGAGTACGACTTGG AGCCCTGTGAGGAGCCCGAGGTCCCAGCCTACAGCATCCGGAAGGGCTTGCAGTTTGGCGTGGGCGACACCTTGACCTTCTCCTGCTTCC CCGGGTACCGTCTGGAGGGCACCGCCCGCATCACGTGCCTGGGGGGCAGACGGCGCCTGTGGAGCTCGCCTCTGCCAAGGTGTGTTGCTG AGTGTGGGAATTCAGTCACAGGCACTCAGGGTACTTTGCTGTCCCCCAACTTTCCTGTGAACTACAATAACAATCATGAATGCATCTACT CCATCCAGACCCAGCCAGGGAAGGGAATTCAGCTGAAAGCCAGGGCATTCGAACTCTCCGAAGGAGATGTCCTCAAGGTTTATGATGGCA ACAACAACTCCGCCCGTTTGCTGGGAGTTTTTAGCCATTCTGAGATGATGGGGGTGACTTTGAACAGCACATCCAGCAGTCTGTGGCTTG ATTTCATCACTGATGCTGAAAACACCAGCAAGGGCTTTGAACTGCACTTTTCCAGCTTTGAACTCATCAAATGTGAGGACCCAGGAACCC CCAAGTTTGGCTACAAGGTTCATGATGAAGGTCATTTTGCAGGGAGCTCCGTGTCCTTCAGCTGTGACCCTGGATACAGCCTGCGGGGTA GTGAGGAGCTGCTGTGTCTGAGTGGAGAGCGCCGGACCTGGGACCGGCCTCTGCCCACCTGTGTCGCCGAGTGTGGAGGGACAGTGAGAG GAGAGGTGTCGGGGCAGGTGCTGTCACCCGGGTATCCAGCTCCCTATGAACACAATCTCAACTGCATCTGGACCATCGAAGCAGAGGCCG GCTGCACCATTGGGCTACACTTCCTGGTGTTTGACACAGAGGAGGTTCACGACGTGCTGCGCATCTGGGATGGGCCTGTGGAGAGCGGGG TTCTGCTGAAGGAGCTGAGTGGCCCGGCCCTGCCCAAGGACCTGCATAGCACCTTCAACTCGGTCGTCCTGCAGTTCAGCACTGACTTCT TCACCAGCAAGCAGGGCTTTGCCATTCAATTTTCAGTGTCCACAGCAACGTCCTGCAATGACCCTGGGATCCCGCAGAATGGGAGTCGGA GTGGTGACAGTTGGGAAGCCGGCGACTCCACAGTGTTCCAGTGTGACCCTGGCTACGCGCTGCAGGGAAGTGCAGAGATCAGCTGTGTGA AGATCGAGAACAGGTTCTTCTGGCAGCCCAGCCCGCCAACATGCATCGCTCCCTGCGGGGGAGACCTGACAGGACCATCTGGAGTCATCC TCTCACCAAATTACCCAGAACCCTACCCGCCAGGCAAGGAGTGTGACTGGAAAGTGACCGTCTCACCAGACTACGTCATCGCCCTGGTAT TTAACATCTTTAACCTGGAGCCTGGCTATGACTTCCTCCATATCTACGACGGACGGGACTCTCTCAGCCCTCTCATAGGAAGCTTCTATG GCTCCCAGCTCCCAGGCCGCATTGAAAGCAGCAGCAACAGCCTCTTCCTCGCCTTCCGCAGCGATGCATCTGTGAGCAATGCTGGCTTCG TCATTGACTATACAGAAAACCCGCGGGAGTCATGTTTTGATCCTGGTTCCATCAAGAACGGCACACGGGTGGGGTCCGACCTGAAGCTGG GCTCCTCCGTCACCTACTACTGCCACGGGGGCTACGAAGTTGAGGGCACCTCGACCCTGAGCTGCATCCTGGGGCCTGATGGGAAGCCCG TGTGGAACAATCCCCGGCCAGTCTGCACAGCCCCCTGTGGGGGACAGTATGTGGGTTCGGACGGAGTGGTCTTGTCCCCCAACTACCCCC AGAACTACACCAGTGGACAGATCTGCTTGTATTTTGTTACTGTGCCCAAGGACTATGTGGTGTTTGGCCAGTTCGCCTTCTTTCACACGG CCCTCAACGACGTGGTGGAGGTTCACGACGGCCACAGCCAGCACTCGCGGCTCCTCAGCTCCCTCTCGGGCTCCCATACAGGAGAATCAC TGCCCTTGGCCACCTCCAATCAAGTTCTCATTAAGTTCAGCGCCAAAGGCCTCGCACCAGCCAGAGGCTTCCACTTTGTCTACCAAGCGG TTCCTCGAACCAGCGCCACGCAGTGCAGCTCTGTGCCGGAACCCCGCTATGGCAAGAGGCTGGGCAGTGACTTCTCGGTGGGGGCCATCG TCCGCTTCGAATGCAACTCCGGCTATGCCCTGCAGGGGTCGCCAGAGATCGAGTGCCTCCCTGTGCCTGGGGCCTTGGCCCAATGGAATG TCTCAGCGCCCACGTGTGTGGTGCCGTGTGGAGGCAACCTCACAGAGCGCAGGGGCACCATCCTGTCCCCTGGCTTCCCAGAGCCGTACC TCAACAGCCTCAACTGTGTGTGGAAGATCGTGGTCCCCGAAGGCGCTGGCATCCAGATCCAAGTTGTCAGTTTTGTGACAGAGCAGAACT GGGACTCGCTGGAAGTATTTGATGGTGCAGATAACACTGTAACCATGCTGGGGAGTTTCTCAGGAACAACCGTGCCTGCCCTTCTGAACA GCACCTCCAACCAGCTCTACCTTCATTTCTACTCAGATATCAGCGTATCTGCAGCTGGCTTCCACTTGGAGTACAAAACGGTGGGCCTGA GCAGTTGTCCGGAACCTGCTGTGCCCAGTAACGGGGTGAAGACTGGCGAGCGCTACTTGGTGAATGATGTGGTGTCTTTCCAGTGTGAGC CGGGATATGCCCTCCAGGGCCACGCCCACATCTCCTGCATGCCCGGAACAGTGCGGCGATGGAACTACCCTCCTCCACTCTGTATTGCAC AGTGTGGGGGAACAGTGGAGGAGATGGAGGGGGTGATCCTGAGCCCCGGCTTCCCAGGCAACTACCCCAGTAACATGGACTGCTCCTGGA AAATAGCACTGCCCGTGGGCTTTGGAGCTCACATCCAGTTCCTGAACTTCTCCACCGAGCCCAACCACGACTACATAGAAATCCGGAATG GCCCCTATGAGACCAGCCGCATGATGGGAAGATTCAGTGGAAGCGAGCTTCCAAGCTCCCTCCTCTCCACGTCCCACGAGACCACCGTGT ATTTCCACAGCGACCACTCCCAGAATCGGCCAGGATTCAAGCTGGAGTATCAGGCCTATGAACTTCAAGAGTGCCCAGACCCAGAGCCCT TTGCCAATGGCATTGTGAGGGGAGCTGGCTACAACGTGGGACAATCAGTGACCTTCGAGTGCCTCCCGGGGTATCAATTGACTGGCCACC CTGTCCTCACGTGTCAACATGGCACCAACCGGAACTGGGACCACCCCCTGCCCAAGTGTGAAGTCCCTTGTGGCGGGAACATCACTTCTT CCAACGGCACTGTGTACTCCCCGGGGTTCCCTAGCCCGTACTCCAGCTCCCAGGACTGTGTCTGGCTGATCACCGTGCCCATTGGCCATG GCGTCCGCCTCAACCTCAGCCTGCTGCAGACAGAGCCCTCTGGAGATTTCATCACCATCTGGGATGGGCCACAGCAAACAGCACCACGGC TCGGCGTCTTCACCCGGAGCATGGCCAAGAAAACAGTGCAGAGTTCATCCAACCAGGTCCTGCTCAAGTTCCACCGTGATGCAGCCACAG GGGGGATCTTCGCCATAGCTTTCTCCGCTTATCCACTCACCAAATGCCCTCCTCCCACCATCCTCCCCAACGCCGAAGTCGTCACAGAGA ATGAAGAATTCAATATAGGTGACATCGTACGCTACAGATGCCTCCCTGGCTTTACCTTAGTGGGGAATGAAATTCTGACCTGCAAACTTG GAACCTACCTGCAGTTTGAAGGACCACCCCCGATATGTGAAGTGCACTGTCCAACAAATGAGCTTCTGACAGACTCCACAGGCGTGATCC TGAGCCAGAGCTACCCTGGAAGCTATCCCCAGTTCCAGACCTGCTCTTGGCTGGTGAGAGTGGAGCCCGACTATAACATCTCCCTCACAG TGGAGTACTTCCTCAGCGAGAAGCAATATGATGAGTTTGAGATTTTTGATGGTCCATCAGGACAGAGTCCTCTGCTGAAAGCCCTCAGTG GGAATTACTCAGCTCCCCTGATTGTCACCAGCTCAAGCAACTCTGTGTACCTGCGTTGGTCATCTGATCACGCCTACAATCGGAAGGGCT TCAAGATCCGCTATTCAGCCCCTTACTGCAGCCTGCCCAGGGCTCCACTCCATGGCTTCATCCTAGGCCAGACCAGCACCCAGCCCGGGG GCTCCATCCACTTTGGCTGCAACGCCGGCTACCGCCTGGTGGGACACAGCATGGCCATCTGTACCCGGCACCCCCAGGGCTACCACCTGT GGAGCGAAGCCATCCCTCTCTGTCAAGCTCTTTCCTGTGGGCTTCCTGAGGCCCCCAAGAATGGAATGGTGTTTGGCAAGGAGTACACAG TGGGAACCAAGGCCATGTACAGCTGCAGTGAAGGCTACCACCTCCAGGCAGGCGCTGAGGCCACTGCAGAGTGTCTGGACACAGGCCTAT GGAGCAACCGCAATGTCCCACCACAGTGTGTCCCTGTGACTTGTCCTGATGTCAGTAGCATCAGCGTGGAGCATGGCCGATGGAGGCTTA TCTTTGAGACACAGTATCAGTTCCAGGCCCAGCTGATGCTCATCTGTGACCCTGGCTACTACTATACTGGCCAAAGGGTCATCCGCTGTC AGGCCAATGGCAAATGGAGCCTCGGGGACTCTACGCCCACCTGCCGAATCATCTCCTGTGGAGAGCTCCCGATTCCCCCCAATGGCCACC GCATCGGAACACTGTCTGTCTACGGGGCAACAGCCATCTTCTCCTGCAATTCCGGATACACACTGGTGGGCTCCAGGGTGCGTGAGTGCA TGGCCAATGGGCTCTGGAGTGGCTCTGAAGTCCGCTGCCTTGCCACTCAGACCAAGCTCCACTCCATTTTCTATAAGCTCCTCTTCGATG TACTCTCTTCCCCATCCCTCACCAAAGCTGGACACTGTGGGACTCCTGAGCCCATTGTCAACGGACACATCAATGGGGAGAACTACAGCT ACCGGGGCAGTGTGGTGTACCAATGCAATGCTGGCTTCCGCCTGATCGGCATGTCTGTGCGCATCTGCCAGCAGGATCATCACTGGTCGG GCAAGACCCCTTTCTGTGTGCCAATTACCTGTGGACACCCAGGCAACCCTGTCAACGGCCTCACTCAGGGTAACCAGTTTAACCTCAACG ATGTGGTCAAGTTTGTTTGCAACCCTGGGTATATGGCTGAGGGGGCTGCTAGGTCCCAATGCCTGGCCAGCGGGCAATGGAGTGACATGC TGCCCACCTGCAGAATCATCAACTGTACAGATCCTGGACACCAAGAAAATAGTGTTCGTCAGGTCCACGCCAGCGGCCCGCACAGGTTCA GCTTCGGCACCACTGTGTCTTACCGGTGCAACCACGGCTTCTACCTCCTGGGCACCCCAGTGCTCAGCTGCCAGGGAGATGGCACATGGG ACCGTCCCCGCCCCCAGTGTCTCTTGGTGTCCTGTGGCCATCCGGGCTCCCCGCCTCACTCCCAGATGTCTGGAGACAGTTATACTGTGG GAGCAGTGGTGCGGTACAGCTGCATCGGCAAGCGTACTCTGGTGGGAAACAGCACCCGCATGTGTGGGCTGGATGGACACTGGACTGGCT CCCTCCCTCACTGCTCAGGAACCAGCGTGGGAGTTTGCGGTGACCCTGGGATCCCGGCTCATGGCATCCGTTTGGGGGACAGCTTTGATC CAGGCACTGTGATGCGCTTCAGCTGTGAAGCTGGCCACGTGCTCCGGGGATCGTCAGAGCGCACCTGTCAAGCCAATGGCTCGTGGAGCG GCTCGCAGCCTGAGTGTGGAGTGATCTCTTGTGGGAACCCTGGGACTCCAAGTAATGCCCGAGTTGTGTTCAGTGATGGCCTGGTTTTCT CCAGCTCTATCGTCTATGAGTGCCGGGAAGGATACTACGCCACAGGCCTGCTCAGCCGTCACTGCTCGGTCAATGGTACCTGGACAGGCA GTGACCCTGAGTGCCTCGTCATAAACTGTGGTGACCCTGGGATTCCAGCCAATGGCCTTCGGCTGGGCAATGACTTCAGGTACAACAAAA CTGTGACATATCAGTGTGTCCCTGGCTATATGATGGAGTCACATAGAGTATCTGTGCTGAGCTGCACCAAGGACCGGACATGGAATGGAA CCAAGCCCGTCTGCAAAGCTCTCATGTGCAAGCCACCTCCGCTCATCCCCAATGGGAAGGTGGTGGGGTCTGACTTCATGTGGGGCTCAA GTGTGACTTATGCCTGCCTGGAGGGGTACCAGCTCTCCCTGCCCGCGGTGTTCACCTGTGAGGGAAATGGGTCCTGGACCGGAGAGCTGC CTCAGTGTTTCCCTGTGTTCTGCGGGGATCCTGGTGTCCCGTCCCGTGGGAGGAGAGAGGACCGAGGCTTCTCCTACAGGTCATCTGTCT CCTTCTCCTGCCATCCCCCTCTGGTGCTGGTGGGCTCTCCACGCAGGTTTTGCCAGTCAGATGGGACATGGAGTGGCACCCAGCCCAGCT GCATAGATCCGACCCTGACCACGTGTGCGGACCCTGGTGTGCCACAGTTTGGGATACAGAACAATTCTCAGGGCTACCAGGTTGGAAGCA CAGTCCTCTTCCGTTGTCAAAAAGGCTACCTGCTTCAGGGCTCCACCACCAGGACCTGCCTCCCAAACCTGACCTGGAGTGGAACCCCAC CTGACTGTGTCCCCCACCACTGCAGGCAGCCAGAGACGCCAACGCATGCCAACGTCGGGGCCCTGGATTTGCCCTCCATGGGCTACACGC TCATCTACTCCTGCCAGGAGGGCTTCTCCCTCAAGGGTGGCTCCGAGCACCGCACCTGCAAGGCGGATGGCAGCTGGACAGGCAAGCCGC CCATCTGCCTGGAGGTCCGGCCCAGTGGGAGACCCATCAACACTGCCCGGGAGCCACCGCTCACCCAAGCCTTGATTCCTGGGGATGTTT TTGCCAAGAATTCCCTGTGGAAAGGGGCCTATGAATACCAGGGGAAGAAGCAGCCAGCCATGCTCAGAGTGACTGGCTTCCAAGTTGCCA ACAGCAAGGTCAATGCCACCATGATCGACCACAGTGGCGTGGAGCTGCACTTGGCTGGAACTTACAAGAAAGAAGATTTTCATCTCCTAC TCCAGGTGTACCAGATTACAGGGCCTGTGGAGATCTTTATGAATAAGTTCAAAGATGATCACTGGGCTTTAGATGGCCATGTCTCGTCAG AGTCCTCCGGAGCCACCTTCATCTACCAAGGCTCTGTCAAGGGCCAAGGCTTTGGGCAGTTCGGCTTTCAAAGACTGGACCTCAGGCTGC TGGAGTCAGACCCCGAGTCCATTGGCCGCCACTTTGCTTCCAACAGCAGCTCAGTGGCAGCCGCGATCCTGGTGCCTTTCATCGCCCTCA TTATTGCGGGCTTCGTGCTCTATCTCTACAAGCACAGGAGAAGACCCAAAGTTCCTTTCAATGGCTATGCTGGCCACGAGAACACCAATG TTCGGGCCACATTTGAGAACCCAATGTACGACCGCAACATCCAGCCCACAGACATCATGGCCAGCGAGGCGGAGTTCACAGTCAGCACAG TGTGCACAGCAGTATAGCCACCCGGCCTGGCCGCCACCACCGCCACCGAGAGCCCCGCCTCCAGCAGCCGTTCCCCAGGGGGCAGGAAGT AGGCTCCCCTGAGCACAGTGCCCAGTGCCCATCTTCGTTCGTCTCCTTGCCTGTGTCTGCTACTGCTGGGACTCAGGCCCTCGCCCTGCC GCCATCTATGCCAGTTACCCTGGAGAGGACTCCTGCCGTGTCCTGAAAAGGCAGAAAAGGAAGAGGGGCTGCAGACAGAGGAAGAAAGTT TATGGATTTAAAATAGCAAAGCAACTTGTGGATCTGTGTGTGTGTGTGTGTGTATGGGCCTGATCACACACAAACACACACACCTCTCCT TCATTCACGTCCTATGGAAGAGACCATAAAGGCTTCAAAACTAGAAGTGCGCATGAAGGATGCTTCATGCCCTGTTCCCCACACAGAGAA GAGATGAAGAGGGGGAGGTACGGTCAGCTTTCAAAACAATATGCCCCCCGCCCATCCCATGTGTGAGGACATGGTGACTCGGTGACTGTA ACAGTAGGACACATCCCATCATGCGGTCAGAGTGCAGAAACCCGGTCAGCGTGCAGAAACCAGCTGTCTGCTGATGAACGGCCCATCTGC ACAGCGGCAGCAAGGATTACCCCAAGGGCAGGAAAAAAGTCTTTGGAAATAGATTGAAAATCAGTTTCTTTATTTTTTTCAAACACTGTT TTATTGAGTTCTAAACCCAGTGGATTAAAAAGTCATTTGGGTCCTGGGAAGCACTGGGAAAGAAGGGAGAGCCGGGGAGGATAGGGCAGG AGTCTGGCCAGGAGCCCAAGGTCAAGTCTGGCTGTCAACTGACAAAGAGAAGAGAAGACAAGTCTGTGGCCCAGACAGGATGCCAAGTCT GGGGGCAGCAGCAGGGTCCTTGAGAGAACAGGGGAGCAAGCCTGCCCCAGTACCCAAAAAACAATGGCTATCATGTACTGGGGTTATTCT CTGTGCCTGACACTTTACCTGTAGTATTTCTAGTCTGCACAATAACACCAAAATGTAGGATTTGTTATTCCCCTTTGACAGATGAGAAAA CAGAAGCCTGCAAAGGTAAAGACAGAGTTAGGAAGTGTGGAGTCAGAATGCAAACCCAGATCAGTCTGCCCCAAAGTCCACTACACCAGC TGCCAGAAACCCTGTTCTAGAAGGGGCAGCTAAGAAGGGAGGAGCCGATGAATCTCTACAGTAGCACTGTGGCCAGGTCTGGAAAGCCAG GCAAGACACCTGTGTGTCCTATCTGGGTTCTGCTGTCTCCGCGTAGGCAGCTTCGGGGCAAGGATTCAACTCCCCAGGCCTCCCACGGTT GGTGCTGGCTCCTTGGCTCCCAGCAGCCGCTGACCATAGCCAGCAAAAGACCTGGCAGGTCCTGAATCAAAACAACAGAGTGGCTGAAAG TCACACCTCTCCAGCTCCTTGCGAGTGGGTTTGATTGATTTTGACAGCTATATCATGCTTGGGTCGTTCATGAATTCCATGAGAATTGTT GGGAAGTTCATGAGTTTAGGAATCAAAGTATAGCATTTAGGGCCACTTTCTCTGTCCTCGGGAAGGCCCCCACAAGCTTAAGCCCCTGTA TACGTGTGACATGCTGGCCTCAGAGATTCATGTCACATATTGAAATAGCAAATAGAAATGTGCAGGAGCGGAGGGACAGCGACACCTGGT TCTTAAGCAAATTCTAGATTGGAACAATTAGAAGATCTGACTGATGTTAAGAGTGGCCAGAGGAAAGTGAGAGGCGTCCATTTCCAGCAG ACACAATGGAGGCTGACAGAGGCAGGAGCCTACCCCTGGCCACACCACCTCTGGGACACGGCACCCCCCTGGGCCTGGAGGGAGAGGGCC AATCCAGACACACTCACACTCTCATCTCTTTCCTTGGCTGGAAACAAGTGCAGGAAGCTCCCCTCCCAATTTCTTATGCTCCCTTCCCCC TTACACTCCTCTCCTTCGACTGCTCCCTTCCCCCTTCTTATGCCCCTCTCAGACCACCCAGCGGATGCCTATTCCCGCCCCCCACCCCTC CCCTGCGTCTCCTTGTAAAGTTCCATGAGATGCTCGAGGAGCACCTGCTGGTGGGGCACCCAGCACTCTGCTGGGCATCACCCTCCGCAC CCCTGACATTTCTCTCCACCTCCAGAGGCTTGGAAGGGAACAGGGCAGATGAGGCCCTTCACCCACCATCTACGCCATATACCCATCACC ATCCCATGAGGAAAAAAAAAAAAGTAAAACAAAGACAAAAAAAATCTTTTGTACAGAGATATATTTTTATTATACAAAGTTTGTACAGTA CCAAAAAAGAAAAAAAAAAAGGTGTAAATTTTTTTTTCATTATTGTAGGTAAACGGTAGTGGAAGCCTTTTTTGTAAATGTAATAAAATG TATAAATATGGTTTTCAGAAAACATCAAGTGCTGTAAATATGTAATCTACACACCTTCTTGGCTTGTCTGCAGTATATACATTTAATTTA TCTGTCTCTGTATATGAGGCTTCCCCCTGGGGTCCTGCATTATGGTACTTTCCTGAATTTGAAAGCAATTTTAAATTTTTTGAATTCAAA >91947_91947_1_TMEM234-CSMD2_TMEM234_chr1_32682860_ENST00000545122_CSMD2_chr1_34258127_ENST00000373381_length(amino acids)=3162AA_BP=13 MLGRPLEKILVENVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQG SCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLIL ARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECPDPGVPVN GKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYP IKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQSDHCLDPGIPVNGQRH GNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTF HLESGHDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGVGD TLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGD VLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCD PGYSLRGSEELLCLSGERRTWDRPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIW DGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQG SAEISCVKIENRFFWQPSPPTCIAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLS PLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCI LGPDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLS GSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVP GALAQWNVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGT TVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNY PPPLCIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLS TSHETTVYFHSDHSQNRPGFKLEYQAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVP CGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLK FHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELL TDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSD HAYNRKGFKIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGM VFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYT GQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLATQTKLHSI FYKLLFDVLSSPSLTKAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQ GNQFNLNDVVKFVCNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLS CQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGI RLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCS VNGTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVG SDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGT WSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALD LPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQPAMLR VTGFQVANSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKFKDDHWALDGHVSSESSGATFIYQGSVKGQGFGQFGF QRLDLRLLESDPESIGRHFASNSSSVAAAILVPFIALIIAGFVLYLYKHRRRPKVPFNGYAGHENTNVRATFENPMYDRNIQPTDIMASE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TMEM234-CSMD2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TMEM234-CSMD2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TMEM234-CSMD2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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