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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMEM241-TRAPPC8 (FusionGDB2 ID:91968)

Fusion Gene Summary for TMEM241-TRAPPC8

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM241-TRAPPC8
	Fusion gene ID: 91968
		Hgene	Tgene
	Gene symbol	TMEM241	TRAPPC8
	Gene ID	85019	22878
	Gene name	transmembrane protein 241	trafficking protein particle complex 8
	Synonyms	C18orf45\|hVVT	GSG1\|HsT2706\|KIAA1012\|TRS85
	Cytomap	18q11.2	18q12.1
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 241putative vertebrate vrg4-like nucleotide-sugar transporter truncated variant2putative vertebrate vrg4-like nucleotide-sugar transporter variant1transmembrane protein C18orf45	trafficking protein particle complex subunit 8general sporulation gene 1 homologprotein TRS85 homolog
	Modification date	20200313	20200313
	UniProtAcc	Q24JQ0	.
	Ensembl transtripts involved in fusion gene	ENST00000542162, ENST00000383233, ENST00000450466, ENST00000399707, ENST00000475185,	ENST00000283351, ENST00000582513, ENST00000582539, ENST00000584876,
Fusion gene scores	* DoF score	11 X 10 X 9=990	18 X 15 X 6=1620
	# samples	13	18
	** MAII score	log2(13/990*10)=-2.92891690193852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1620*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TMEM241 [Title/Abstract] AND TRAPPC8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM241(20948678)-TRAPPC8(29477854), # samples:2
Anticipated loss of major functional domain due to fusion event.	TMEM241-TRAPPC8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TMEM241-TRAPPC8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TMEM241 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRAPPC8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-VR-A8EQ	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-

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Fusion Gene ORF analysis for TMEM241-TRAPPC8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000542162	ENST00000283351	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
3UTR-3CDS	ENST00000542162	ENST00000582513	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
3UTR-3CDS	ENST00000542162	ENST00000582539	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
3UTR-intron	ENST00000542162	ENST00000584876	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
5CDS-intron	ENST00000383233	ENST00000584876	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
5CDS-intron	ENST00000450466	ENST00000584876	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
Frame-shift	ENST00000450466	ENST00000283351	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
Frame-shift	ENST00000450466	ENST00000582513	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
Frame-shift	ENST00000450466	ENST00000582539	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
In-frame	ENST00000383233	ENST00000283351	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
In-frame	ENST00000383233	ENST00000582513	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
In-frame	ENST00000383233	ENST00000582539	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
intron-3CDS	ENST00000399707	ENST00000283351	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
intron-3CDS	ENST00000399707	ENST00000582513	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
intron-3CDS	ENST00000399707	ENST00000582539	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
intron-3CDS	ENST00000475185	ENST00000283351	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
intron-3CDS	ENST00000475185	ENST00000582513	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
intron-3CDS	ENST00000475185	ENST00000582539	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
intron-intron	ENST00000399707	ENST00000584876	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-
intron-intron	ENST00000475185	ENST00000584876	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000383233	TMEM241	chr18	20948678	-	ENST00000283351	TRAPPC8	chr18	29477854	-	5019	619	53	3436	1127
ENST00000383233	TMEM241	chr18	20948678	-	ENST00000582539	TRAPPC8	chr18	29477854	-	3602	619	53	3436	1127
ENST00000383233	TMEM241	chr18	20948678	-	ENST00000582513	TRAPPC8	chr18	29477854	-	1992	619	53	1129	358

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000383233	ENST00000283351	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-	8.25E-05	0.9999175
ENST00000383233	ENST00000582539	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-	0.000133106	0.99986684
ENST00000383233	ENST00000582513	TMEM241	chr18	20948678	-	TRAPPC8	chr18	29477854	-	0.001001506	0.99899846

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Fusion Genomic Features for TMEM241-TRAPPC8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM241-TRAPPC8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:20948678/chr18:29477854)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TMEM241 Q24JQ0	.
	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000383233

121_141

188

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000383233

146_166

188

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000383233

32_52

188

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000383233

67_87

188

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000383233

7_29

188

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000383233

93_113

188

297.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000383233

187_207

188

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000383233

211_231

188

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000383233

250_270

188

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000383233

271_291

188

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000399707

121_141

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000399707

146_166

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000399707

187_207

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000399707

211_231

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000399707

250_270

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000399707

271_291

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000399707

32_52

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000399707

67_87

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000399707

7_29

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20948678

chr18:29477854

ENST00000399707

93_113

124.0

Transmembrane

Helical

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Fusion Gene Sequence for TMEM241-TRAPPC8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>91968_91968_1_TMEM241-TRAPPC8_TMEM241_chr18_20948678_ENST00000383233_TRAPPC8_chr18_29477854_ENST00000283351_length(transcript)=5019nt_BP=619nt
CCAGGGGATTTGGGCAGGCACCGTGGATCCCCGAGAAGGGGACGAGTTGACAGATGTGCGTGAGGAGGTCTCTGGTCGGCCTCACCTTTT
GTACCTGCTACCTGGCTTCTTACCTCACGAACAAGTATGTGCTGTCTGTCTTGAAATTTACCTACCCTACATTATTCCAAGGGTGGCAGA
CGCTCATTGGTGGACTTTTGCTTCATGTGTCCTGGAAACTGGGCTGGGTAGAGATCAACAGCAGTTCAAGATCTCATGTTCTTGTGTGGC
TTCCTGCTTCAGTGCTGTTTGTGGGTATAATCTATGCTGGGTCCAGAGCATTGTCCAGACTGGCCATTCCTGTGTTTCTCACTTTGCATA
ATGTAGCTGAAGTTATCATCTGTGGGTACCAGAAGTGTTTTCAGAAAGAGAAAACATCTCCTGCAAAGATCTGTAGTGCCCTCCTCCTCC
TGGCCGCAGCAGGATGCCTTCCCTTCAATGACTCCCAGTTTAATCCAGATGGATATTTTTGGGCTATAATTCACTTACTCTGTGTAGGGG
CTTATAAAATTCTACAGAAGTCCCAGAAACCCAGTGCATTAAGTGACATTGACCAGCAATACTTAAACTATATATTCAGGAATATGGTGT
TGGCTGAAAGATGTGTGTTGCTTAGTGCTGAACTTTTAAAAAGCCAAAGCAAATATTCAGAGGCTGCAGCTCTCCTAATACGGTTGACCA
GTGAGGATTCTGATCTTCGAAGTGCACTTCTTTTGGAACAGGCAGCACATTGCTTTATAAACATGAAAAGTCCCATGGTTAGAAAATATG
CATTTCATATGATATTGGCAGGCCATCGATTTAGTAAAGCAGGGCAGAAAAAGCATGCTTTACGCTGTTATTGTCAAGCCATGCAAGTTT
ACAAAGGAAAAGGCTGGTCTCTTGCAGAGGATCACATTAATTTCACTATTGGGCGCCAGTCCTATACTCTTAGACAGCTGGATAATGCTG
TGTCTGCTTTTAGGCATATTCTAATTAATGAAAGTAAACAATCTGCTGCTCAACAGGGGGCTTTCCTCAGAGAATATCTTTATGTTTACA
AGAATGTAAGTCAGCTGTCACCAGATGGTCCTTTGCCACAGCTTCCTTTACCGTATATTAACAGTTCAGCAACACGGGTTTTTTTTGGCC
ATGACAGACGACCAGCGGATGGTGAAAAACAAGCAGCTACTCATGTAAGTCTTGATCAAGAATATGATTCTGAATCCTCTCAGCAGTGGC
GAGAACTTGAGGAACAAGTTGTTTCTGTGGTTAACAAAGGAGTAATTCCATCCAATTTTCATCCCACACAATACTGTTTGAACAGTTACT
CAGATAATTCAAGATTTCCACTTGCAGTTGTAGAAGAACCAATTACAGTGGAAGTGGCTTTTAGAAACCCTTTGAAAGTTCTACTTTTGT
TGACTGATTTGTCATTGCTTTGGAAGTTTCATCCTAAAGATTTCAGTGGAAAGGATAATGAAGAAGTTAAACAACTAGTTACAAGTGAAC
CTGAAATGATTGGAGCTGAAGTTATTTCAGAGTTCTTAATTAATGGCGAAGAATCAAAAGTGGCAAGACTAAAGCTCTTTCCCCATCACA
TAGGGGAGCTGCATATTCTGGGAGTTGTTTATAATCTTGGCACTATTCAGGGCTCTATGACAGTAGATGGCATTGGTGCTCTTCCCGGAT
GTCACACAGGAAAATATTCCTTGAGTATGTCAGTCCGAGGGAAGCAGGATTTAGAAATTCAAGGTCCTCGACTTAACAACACAAAAGAAG
AGAAAACATCTGTTAAATATGGCCCTGATCGACGTTTAGATCCCATAATCACAGAAGAAATGCCACTGTTGGAGGTGTTCTTTATACATT
TTCCTACAGGGCTTCTCTGTGGAGAAATCCGAAAAGCATATGTAGAATTTGTCAATGTCAGCAAATGTCCACTTACTGGATTGAAGGTTG
TTTCTAAACGTCCAGAGTTCTTTACTTTCGGTGGTAATACTGCTGTTCTAACACCACTAAGTCCCTCAGCTTCTGAGAATTGTAGTGCTT
ACAAGACTGTTGTGACAGATGCTACCTCTGTGTGTACAGCACTCATATCATCAGCTTCTTCTGTAGACTTTGGCATTGGCACAGGAAGTC
AACCAGAGGTGATTCCTGTTCCCCTTCCTGACACTGTTCTTCTACCCGGAGCCTCAGTGCAGCTGCCAATGTGGTTACGTGGGCCTGATG
AAGAAGGTGTCCATGAAATTAACTTTTTGTTTTACTATGAAAGTGTCAAAAAGCAGCCAAAAATACGGCACAGAATATTAAGACACACTG
CAATTATTTGTACCAGTCGGTCTTTAAATGTACGGGCCACTGTCTGCAGAAGTAATTCTCTTGAAAATGAAGAAGGCAGAGGAGGCAATA
TGCTAGTCTTTGTGGATGTGGAAAATACCAATACTAGTGAAGCAGGCGTTAAGGAATTCCACATAGTGCAAGTATCAAGTAGTAGCAAAC
ACTGGAAGTTACAGAAATCTGTAAATCTTTCTGAAAACAAAGATACCAAACTTGCCAGTAGGGAGAAGGGAAAGTTTTGCTTTAAGGCAA
TAAGATGTGAGAAAGAAGAAGCGGCCACACAGTCCTCTGAAAAATATACCTTTGCAGATATCATCTTTGGAAATGAACAGATAATAAGTT
CAGCAAGCCCATGTGCAGACTTCTTTTATCGAAGTTTATCTTCTGAATTGAAAAAACCACAAGCTCACTTGCCTGTGCATACAGAAAAAC
AGTCAACAGAGGATGCTGTGAGATTGATTCAAAAATGCAGTGAGGTAGATTTGAATATTGTCATATTATGGAAGGCATACGTTGTGGAAG
ACAGTAAACAGCTTATTTTGGAAGGTCAACATCATGTTATTCTTCGCACTATAGGAAAAGAAGCCTTTTCATATCCTCAGAAACAGGAGC
CACCAGAAATGGAACTATTGAAATTTTTCAGGCCAGAAAACATTACAGTTTCCTCAAGGCCATCAGTAGAGCAGCTTTCTAGTCTCATTA
AAACGAGTCTTCACTACCCAGAATCATTTAATCATCCATTTCATCAAAAAAGCCTTTGTTTAGTACCAGTCACTCTTTTACTTTCCAATT
GTTCTAAGGCTGATGTAGATGTCATAGTTGATCTTCGGCATAAAACAACAAGTCCAGAAGCACTGGAAATCCATGGATCATTCACATGGC
TTGGACAAACACAGTATAAACTTCAACTTAAAAGCCAGGAGATTCACAGTCTGCAGCTGAAAGCATGCTTTGTTCATACAGGTGTTTATA
ACCTTGGAACTCCTAGGGTATTTGCCAAGTTATCGGACCAAGTTACAGTGTTTGAAACAAGTCAGCAGAATTCCATGCCTGCCCTGATCA
TCATCAGTAATGTGTGACAACTTGGAAATTTGTACTGAAATCCACAATAATCAGTTTTTGCTGGATGGGTTTTACAGCAGTATTTGATAT
ACCTAACTTGTTATGGAGGTTGATTGATATCTGATCCCTGCAAAATACTTTGACTTGTCATTTTGTTGATGATGCAAAGCACGTTGGACT
GAGAATACTTAACATTCTTTTTCTGTATTTCTTTAAACCCTGAGAATAATTTACATGCTCATAATACAGGATATCAGCATATTTGTGCAC
CTTATTAAGCCCCATCTTAAGAAAACACAAAGTCTAAGTCTGCTGTTACAACTTGTCAATGGTATACGAATATTAGGAGATGATTCTGAG
AAAGGAAAGGCCTTGTTGGCAGTACTCCTGTTAAGCCATTAGTCTCTAAATTCCAGCTTTACTGTGAAGTTCTATAGAGTGTTAAATACA
AATTTTCCTGTCTTGCTTCACACAGTTCCTTAAAATCAGTTTTGAACTTTGGTCATAGAGTCTTCATATTTCAGTATTTGGTGGTCCCTA
TGACTTATACATAACTTTGTAAAAAGAAAAAAAAATTTTTTCTGATGCTTTGAATATAGTTTTGAAAGGAGTTTTGACTTTTTTCCCCTC
ATTCATCTCAGTATAGAGTGCGCTATTTCACAATACGATTTTTGTCATTAAAATTACCATATTCTTTATTATATAACGTTAACTATTGAG
TTGATCTGTTTAAAATATAAATCTCAAGTTAATTAAAAATAAGCTTTTCAAAAATGTATTATATTTATAACAAATATACTGTAAATAGAA
TAAAGACATGCTATTCACTGTATAGCGTATTAGTATCTGTTGATTAGAAAGTCTGGTTTCAAAATATTTTTTTATTCAGAGAATGGGCAT
TTGGACATAAGAAATTTCAATTCAGCCCTGCTGCAGATAGAGAAATGGGAGCAAGGTTGTTTCAATGAATATCTCTTGTCATTGGAGAAG
GAGGGAAGACAGGGTGTAGGAGTGGGTGGCAGGGAGTACAAGAGCCAGGGTCAGTCAAGTCTGGAGCAGATGGGGTCCTTGTGCCATTGA
CAGCTACCATGGTTTGTTCCAGTCTCAATCTCGGCACTAATCGGAGCAGACTGCACCAAAGTGGGGAGAGATCAAAAGACCCCGTTTTCA
GACTGAAGATTCCAAACCTGTACTTGGAACAACTCTTCTTGAGAGATGGGTGGCTAGTCTGTGTGCCTCTCTGCAACTGCTGCTTATGCT
TCTGGATCTTAAGTGGGTCTCTGGCTTTTCAGCTCCTTCCACTCTGTGTCTTAGCAGGTGTGGGACAAGTTGGAGAGGAAGGTCACATTC
TAAGGACACTCATTTCCTTCTTGAGAGTTTAGGGCCATGGGCTTATAAAAAGTCTGAGGAGGAAAGACAAGAATGAGGAGGCATAATCAC
AGTGGTATCTCATATTTAAACCACTCAGCTGAATATTAAATTGAACCGATTGTTAAACAGACACTAATAAAAAAATTAAACTATATAAAC

>91968_91968_1_TMEM241-TRAPPC8_TMEM241_chr18_20948678_ENST00000383233_TRAPPC8_chr18_29477854_ENST00000283351_length(amino acids)=1127AA_BP=188
MCVRRSLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLIGGLLLHVSWKLGWVEINSSSRSHVLVWLPASVLFVGIIYAGSRAL
SRLAIPVFLTLHNVAEVIICGYQKCFQKEKTSPAKICSALLLLAAAGCLPFNDSQFNPDGYFWAIIHLLCVGAYKILQKSQKPSALSDID
QQYLNYIFRNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSALLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKK
HALRCYCQAMQVYKGKGWSLAEDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDGPLPQLPLP
YINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSVVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVE
VAFRNPLKVLLLLTDLSLLWKFHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVVYNLGTIQG
SMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPDRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFV
NVSKCPLTGLKVVSKRPEFFTFGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLPDTVLLPGA
SVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLNVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVK
EFHIVQVSSSSKHWKLQKSVNLSENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFYRSLSSELK
KPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQHHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVS
SRPSVEQLSSLIKTSLHYPESFNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQLKSQEIHSL

--------------------------------------------------------------
>91968_91968_2_TMEM241-TRAPPC8_TMEM241_chr18_20948678_ENST00000383233_TRAPPC8_chr18_29477854_ENST00000582513_length(transcript)=1992nt_BP=619nt
CCAGGGGATTTGGGCAGGCACCGTGGATCCCCGAGAAGGGGACGAGTTGACAGATGTGCGTGAGGAGGTCTCTGGTCGGCCTCACCTTTT
GTACCTGCTACCTGGCTTCTTACCTCACGAACAAGTATGTGCTGTCTGTCTTGAAATTTACCTACCCTACATTATTCCAAGGGTGGCAGA
CGCTCATTGGTGGACTTTTGCTTCATGTGTCCTGGAAACTGGGCTGGGTAGAGATCAACAGCAGTTCAAGATCTCATGTTCTTGTGTGGC
TTCCTGCTTCAGTGCTGTTTGTGGGTATAATCTATGCTGGGTCCAGAGCATTGTCCAGACTGGCCATTCCTGTGTTTCTCACTTTGCATA
ATGTAGCTGAAGTTATCATCTGTGGGTACCAGAAGTGTTTTCAGAAAGAGAAAACATCTCCTGCAAAGATCTGTAGTGCCCTCCTCCTCC
TGGCCGCAGCAGGATGCCTTCCCTTCAATGACTCCCAGTTTAATCCAGATGGATATTTTTGGGCTATAATTCACTTACTCTGTGTAGGGG
CTTATAAAATTCTACAGAAGTCCCAGAAACCCAGTGCATTAAGTGACATTGACCAGCAATACTTAAACTATATATTCAGGAATATGGTGT
TGGCTGAAAGATGTGTGTTGCTTAGTGCTGAACTTTTAAAAAGCCAAAGCAAATATTCAGAGGCTGCAGCTCTCCTAATACGGTTGACCA
GTGAGGATTCTGATCTTCGAAGTGCACTTCTTTTGGAACAGGCAGCACATTGCTTTATAAACATGAAAAGTCCCATGGTTAGAAAATATG
CATTTCATATGATATTGGCAGGCCATCGATTTAGTAAAGCAGGGCAGAAAAAGCATGCTTTACGCTGTTATTGTCAAGCCATGCAAGTTT
ACAAAGGAAAAGGCTGGTCTCTTGCAGAGGATCACATTAATTTCACTATTGGGCGCCAGTCCTATACTCTTAGACAGCTGGATAATGCTG
TGTCTGCTTTTAGGCATATTCTAATTAATGAAAGTAAACAATCTGCTGCTCAACAGGGGGCTTTCCTCAGAGAATATCTTTATGTTTACA
AGGTGACTGCTTATTTTCATTCAGGAATAGATATTAAAACTGTATTTTAGTGTGAAAGTATTTATTTATTACCATATCTTACGATAGTTT
TATTAGAATATATGTAGTTATCAGTCATAAAAAAGCTGTGGCAGGCTAGGCTTTTTGGCTATAGATCTTGGTTACATTGCCCCTTCCACA
GTTCTTGAAAAGAGAATTTTAATATTACAATGAACACTTGATTTGTGGCTGTTCTTAGAATCTTAAAAAAAAAAAAGATTCCACAGGTTT
TCTGGATTCTTTATTCATCATGCTTTTATAGACTCACAACTGATTTTACAGTTGGTTTTAAGTGGGTTCTCTTTACCATCCTTTGGAGAT
GGACATTCTATGTTCTTTTCCTTGTGAAAGATGAGGGGGTATGGATCTGTGGAAAGTAGACAGGCTATTATGGTGCAATGGAGAAAAATT
AACAGGAAGAAGGACTGTTTCACTGAGGCAAGCAGATAAACATATAAAGCATTGTTTTATGGAAAAAATGGGAAGTTGTAAATTTTTTCC
CAAGGCCTATGAATAGTGCATATTATATCTATCGTGCAGAAAATAACTACCTTTAGGGTCTAGACTTTATTAATTTGAAATTATATGGGT
TAGAATTTTGGCAGATAGGATGCTATAATGAGTCATAAGAAGTAAAACGCTTACTAAAATAAGTTTTGCATATTTAACATCCAGGTAATT
AGCTGAGTAACCTCAGTAAGATTCTTTTGAGGCAGAATAAATATCTGAAGTGCTTCTGAGTTGTAAAATTTTATGACTGATATGAGAAAT
AAAACTAGTAATTACATATCTTAATATTCTTGCTTAACATATTTTTAATGCCTTGTGTATTAAGAAACGAGGAAACAAATAAAAATACCA

>91968_91968_2_TMEM241-TRAPPC8_TMEM241_chr18_20948678_ENST00000383233_TRAPPC8_chr18_29477854_ENST00000582513_length(amino acids)=358AA_BP=188
MCVRRSLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLIGGLLLHVSWKLGWVEINSSSRSHVLVWLPASVLFVGIIYAGSRAL
SRLAIPVFLTLHNVAEVIICGYQKCFQKEKTSPAKICSALLLLAAAGCLPFNDSQFNPDGYFWAIIHLLCVGAYKILQKSQKPSALSDID
QQYLNYIFRNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSALLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKK

--------------------------------------------------------------
>91968_91968_3_TMEM241-TRAPPC8_TMEM241_chr18_20948678_ENST00000383233_TRAPPC8_chr18_29477854_ENST00000582539_length(transcript)=3602nt_BP=619nt
CCAGGGGATTTGGGCAGGCACCGTGGATCCCCGAGAAGGGGACGAGTTGACAGATGTGCGTGAGGAGGTCTCTGGTCGGCCTCACCTTTT
GTACCTGCTACCTGGCTTCTTACCTCACGAACAAGTATGTGCTGTCTGTCTTGAAATTTACCTACCCTACATTATTCCAAGGGTGGCAGA
CGCTCATTGGTGGACTTTTGCTTCATGTGTCCTGGAAACTGGGCTGGGTAGAGATCAACAGCAGTTCAAGATCTCATGTTCTTGTGTGGC
TTCCTGCTTCAGTGCTGTTTGTGGGTATAATCTATGCTGGGTCCAGAGCATTGTCCAGACTGGCCATTCCTGTGTTTCTCACTTTGCATA
ATGTAGCTGAAGTTATCATCTGTGGGTACCAGAAGTGTTTTCAGAAAGAGAAAACATCTCCTGCAAAGATCTGTAGTGCCCTCCTCCTCC
TGGCCGCAGCAGGATGCCTTCCCTTCAATGACTCCCAGTTTAATCCAGATGGATATTTTTGGGCTATAATTCACTTACTCTGTGTAGGGG
CTTATAAAATTCTACAGAAGTCCCAGAAACCCAGTGCATTAAGTGACATTGACCAGCAATACTTAAACTATATATTCAGGAATATGGTGT
TGGCTGAAAGATGTGTGTTGCTTAGTGCTGAACTTTTAAAAAGCCAAAGCAAATATTCAGAGGCTGCAGCTCTCCTAATACGGTTGACCA
GTGAGGATTCTGATCTTCGAAGTGCACTTCTTTTGGAACAGGCAGCACATTGCTTTATAAACATGAAAAGTCCCATGGTTAGAAAATATG
CATTTCATATGATATTGGCAGGCCATCGATTTAGTAAAGCAGGGCAGAAAAAGCATGCTTTACGCTGTTATTGTCAAGCCATGCAAGTTT
ACAAAGGAAAAGGCTGGTCTCTTGCAGAGGATCACATTAATTTCACTATTGGGCGCCAGTCCTATACTCTTAGACAGCTGGATAATGCTG
TGTCTGCTTTTAGGCATATTCTAATTAATGAAAGTAAACAATCTGCTGCTCAACAGGGGGCTTTCCTCAGAGAATATCTTTATGTTTACA
AGAATGTAAGTCAGCTGTCACCAGATGGTCCTTTGCCACAGCTTCCTTTACCGTATATTAACAGTTCAGCAACACGGGTTTTTTTTGGCC
ATGACAGACGACCAGCGGATGGTGAAAAACAAGCAGCTACTCATGTAAGTCTTGATCAAGAATATGATTCTGAATCCTCTCAGCAGTGGC
GAGAACTTGAGGAACAAGTTGTTTCTGTGGTTAACAAAGGAGTAATTCCATCCAATTTTCATCCCACACAATACTGTTTGAACAGTTACT
CAGATAATTCAAGATTTCCACTTGCAGTTGTAGAAGAACCAATTACAGTGGAAGTGGCTTTTAGAAACCCTTTGAAAGTTCTACTTTTGT
TGACTGATTTGTCATTGCTTTGGAAGTTTCATCCTAAAGATTTCAGTGGAAAGGATAATGAAGAAGTTAAACAACTAGTTACAAGTGAAC
CTGAAATGATTGGAGCTGAAGTTATTTCAGAGTTCTTAATTAATGGCGAAGAATCAAAAGTGGCAAGACTAAAGCTCTTTCCCCATCACA
TAGGGGAGCTGCATATTCTGGGAGTTGTTTATAATCTTGGCACTATTCAGGGCTCTATGACAGTAGATGGCATTGGTGCTCTTCCCGGAT
GTCACACAGGAAAATATTCCTTGAGTATGTCAGTCCGAGGGAAGCAGGATTTAGAAATTCAAGGTCCTCGACTTAACAACACAAAAGAAG
AGAAAACATCTGTTAAATATGGCCCTGATCGACGTTTAGATCCCATAATCACAGAAGAAATGCCACTGTTGGAGGTGTTCTTTATACATT
TTCCTACAGGGCTTCTCTGTGGAGAAATCCGAAAAGCATATGTAGAATTTGTCAATGTCAGCAAATGTCCACTTACTGGATTGAAGGTTG
TTTCTAAACGTCCAGAGTTCTTTACTTTCGGTGGTAATACTGCTGTTCTAACACCACTAAGTCCCTCAGCTTCTGAGAATTGTAGTGCTT
ACAAGACTGTTGTGACAGATGCTACCTCTGTGTGTACAGCACTCATATCATCAGCTTCTTCTGTAGACTTTGGCATTGGCACAGGAAGTC
AACCAGAGGTGATTCCTGTTCCCCTTCCTGACACTGTTCTTCTACCCGGAGCCTCAGTGCAGCTGCCAATGTGGTTACGTGGGCCTGATG
AAGAAGGTGTCCATGAAATTAACTTTTTGTTTTACTATGAAAGTGTCAAAAAGCAGCCAAAAATACGGCACAGAATATTAAGACACACTG
CAATTATTTGTACCAGTCGGTCTTTAAATGTACGGGCCACTGTCTGCAGAAGTAATTCTCTTGAAAATGAAGAAGGCAGAGGAGGCAATA
TGCTAGTCTTTGTGGATGTGGAAAATACCAATACTAGTGAAGCAGGCGTTAAGGAATTCCACATAGTGCAAGTATCAAGTAGTAGCAAAC
ACTGGAAGTTACAGAAATCTGTAAATCTTTCTGAAAACAAAGATACCAAACTTGCCAGTAGGGAGAAGGGAAAGTTTTGCTTTAAGGCAA
TAAGATGTGAGAAAGAAGAAGCGGCCACACAGTCCTCTGAAAAATATACCTTTGCAGATATCATCTTTGGAAATGAACAGATAATAAGTT
CAGCAAGCCCATGTGCAGACTTCTTTTATCGAAGTTTATCTTCTGAATTGAAAAAACCACAAGCTCACTTGCCTGTGCATACAGAAAAAC
AGTCAACAGAGGATGCTGTGAGATTGATTCAAAAATGCAGTGAGGTAGATTTGAATATTGTCATATTATGGAAGGCATACGTTGTGGAAG
ACAGTAAACAGCTTATTTTGGAAGGTCAACATCATGTTATTCTTCGCACTATAGGAAAAGAAGCCTTTTCATATCCTCAGAAACAGGAGC
CACCAGAAATGGAACTATTGAAATTTTTCAGGCCAGAAAACATTACAGTTTCCTCAAGGCCATCAGTAGAGCAGCTTTCTAGTCTCATTA
AAACGAGTCTTCACTACCCAGAATCATTTAATCATCCATTTCATCAAAAAAGCCTTTGTTTAGTACCAGTCACTCTTTTACTTTCCAATT
GTTCTAAGGCTGATGTAGATGTCATAGTTGATCTTCGGCATAAAACAACAAGTCCAGAAGCACTGGAAATCCATGGATCATTCACATGGC
TTGGACAAACACAGTATAAACTTCAACTTAAAAGCCAGGAGATTCACAGTCTGCAGCTGAAAGCATGCTTTGTTCATACAGGTGTTTATA
ACCTTGGAACTCCTAGGGTATTTGCCAAGTTATCGGACCAAGTTACAGTGTTTGAAACAAGTCAGCAGAATTCCATGCCTGCCCTGATCA
TCATCAGTAATGTGTGACAACTTGGAAATTTGTACTGAAATCCACAATAATCAGTTTTTGCTGGATGGGTTTTACAGCAGTATTTGATAT
ACCTAACTTGTTATGGAGGTTGATTGATATCTGATCCCTGCAAAATACTTTGACTTGTCATTTTGTTGATGATGCAAAGCACGTTGGACT

>91968_91968_3_TMEM241-TRAPPC8_TMEM241_chr18_20948678_ENST00000383233_TRAPPC8_chr18_29477854_ENST00000582539_length(amino acids)=1127AA_BP=188
MCVRRSLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLIGGLLLHVSWKLGWVEINSSSRSHVLVWLPASVLFVGIIYAGSRAL
SRLAIPVFLTLHNVAEVIICGYQKCFQKEKTSPAKICSALLLLAAAGCLPFNDSQFNPDGYFWAIIHLLCVGAYKILQKSQKPSALSDID
QQYLNYIFRNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSALLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKK
HALRCYCQAMQVYKGKGWSLAEDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDGPLPQLPLP
YINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSVVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVE
VAFRNPLKVLLLLTDLSLLWKFHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVVYNLGTIQG
SMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPDRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFV
NVSKCPLTGLKVVSKRPEFFTFGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLPDTVLLPGA
SVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLNVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVK
EFHIVQVSSSSKHWKLQKSVNLSENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFYRSLSSELK
KPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQHHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVS
SRPSVEQLSSLIKTSLHYPESFNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQLKSQEIHSL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TMEM241-TRAPPC8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TMEM241-TRAPPC8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TMEM241-TRAPPC8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source