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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMEM241-TTC39C (FusionGDB2 ID:91970)

Fusion Gene Summary for TMEM241-TTC39C

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM241-TTC39C
	Fusion gene ID: 91970
		Hgene	Tgene
	Gene symbol	TMEM241	TTC39C
	Gene ID	85019	125488
	Gene name	transmembrane protein 241	tetratricopeptide repeat domain 39C
	Synonyms	C18orf45\|hVVT	C18orf17\|HsT2697
	Cytomap	18q11.2	18q11.2
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 241putative vertebrate vrg4-like nucleotide-sugar transporter truncated variant2putative vertebrate vrg4-like nucleotide-sugar transporter variant1transmembrane protein C18orf45	tetratricopeptide repeat protein 39CTPR repeat protein 39C
	Modification date	20200313	20200313
	UniProtAcc	Q24JQ0	.
	Ensembl transtripts involved in fusion gene	ENST00000383233, ENST00000399707, ENST00000542162, ENST00000450466, ENST00000475185,	ENST00000540918, ENST00000577185, ENST00000578150, ENST00000584250, ENST00000304621, ENST00000317571,
Fusion gene scores	* DoF score	11 X 10 X 9=990	11 X 8 X 8=704
	# samples	13	12
	** MAII score	log2(13/990*10)=-2.92891690193852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/704*10)=-2.55254102302878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TMEM241 [Title/Abstract] AND TTC39C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM241(20979530)-TTC39C(21694518), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TMEM241 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TTC39C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	MESO	TCGA-ZN-A9VQ-01A	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
ChimerDB4	MESO	TCGA-ZN-A9VQ	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+

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Fusion Gene ORF analysis for TMEM241-TTC39C

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000383233	ENST00000540918	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
5CDS-intron	ENST00000383233	ENST00000577185	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
5CDS-intron	ENST00000383233	ENST00000578150	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
5CDS-intron	ENST00000383233	ENST00000584250	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
5CDS-intron	ENST00000399707	ENST00000540918	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
5CDS-intron	ENST00000399707	ENST00000577185	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
5CDS-intron	ENST00000399707	ENST00000578150	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
5CDS-intron	ENST00000399707	ENST00000584250	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
5CDS-intron	ENST00000542162	ENST00000540918	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
5CDS-intron	ENST00000542162	ENST00000577185	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
5CDS-intron	ENST00000542162	ENST00000578150	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
5CDS-intron	ENST00000542162	ENST00000584250	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
In-frame	ENST00000383233	ENST00000304621	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
In-frame	ENST00000383233	ENST00000317571	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
In-frame	ENST00000399707	ENST00000304621	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
In-frame	ENST00000399707	ENST00000317571	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
In-frame	ENST00000542162	ENST00000304621	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
In-frame	ENST00000542162	ENST00000317571	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
intron-3CDS	ENST00000450466	ENST00000304621	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
intron-3CDS	ENST00000450466	ENST00000317571	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
intron-3CDS	ENST00000475185	ENST00000304621	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
intron-3CDS	ENST00000475185	ENST00000317571	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
intron-intron	ENST00000450466	ENST00000540918	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
intron-intron	ENST00000450466	ENST00000577185	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
intron-intron	ENST00000450466	ENST00000578150	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
intron-intron	ENST00000450466	ENST00000584250	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
intron-intron	ENST00000475185	ENST00000540918	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
intron-intron	ENST00000475185	ENST00000577185	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
intron-intron	ENST00000475185	ENST00000578150	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+
intron-intron	ENST00000475185	ENST00000584250	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000383233	TMEM241	chr18	20979530	-	ENST00000304621	TTC39C	chr18	21694518	+	1553	332	53	1099	348
ENST00000383233	TMEM241	chr18	20979530	-	ENST00000317571	TTC39C	chr18	21694518	+	1554	332	53	1099	348
ENST00000542162	TMEM241	chr18	20979530	-	ENST00000304621	TTC39C	chr18	21694518	+	1501	280	1	1047	348
ENST00000542162	TMEM241	chr18	20979530	-	ENST00000317571	TTC39C	chr18	21694518	+	1502	280	1	1047	348
ENST00000399707	TMEM241	chr18	20979530	-	ENST00000304621	TTC39C	chr18	21694518	+	1531	310	109	1077	322
ENST00000399707	TMEM241	chr18	20979530	-	ENST00000317571	TTC39C	chr18	21694518	+	1532	310	109	1077	322

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000383233	ENST00000304621	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+	0.000530787	0.9994692
ENST00000383233	ENST00000317571	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+	0.000520379	0.9994796
ENST00000542162	ENST00000304621	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+	0.000519875	0.9994802
ENST00000542162	ENST00000317571	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+	0.00051022	0.9994898
ENST00000399707	ENST00000304621	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+	0.00043238	0.99956757
ENST00000399707	ENST00000317571	TMEM241	chr18	20979530	-	TTC39C	chr18	21694518	+	0.000427304	0.9995727

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Fusion Genomic Features for TMEM241-TTC39C

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TMEM241	chr18	20979529	-	TTC39C	chr18	21694517	+	1.82E-05	0.99998176
TMEM241	chr18	20979529	-	TTC39C	chr18	21694517	+	1.82E-05	0.99998176
TMEM241	chr18	20979529	-	TTC39C	chr18	21694517	+	1.82E-05	0.99998176
TMEM241	chr18	20979529	-	TTC39C	chr18	21694517	+	1.82E-05	0.99998176

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM241-TTC39C

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:20979530/chr18:21694518)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TMEM241 Q24JQ0	.
	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000383233

32_52

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000383233

67_87

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000383233

7_29

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000399707

32_52

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000399707

7_29

124.0

Transmembrane

Helical

Tgene

TTC39C

chr18:20979530

chr18:21694518

ENST00000584250

19_25

77.0

Compositional bias

Note=Poly-Ala

Tgene

TTC39C

chr18:20979530

chr18:21694518

ENST00000304621

315_348

267

523.0

Repeat

Note=TPR 1

Tgene

TTC39C

chr18:20979530

chr18:21694518

ENST00000304621

353_386

267

523.0

Repeat

Note=TPR 2

Tgene

TTC39C

chr18:20979530

chr18:21694518

ENST00000304621

485_518

267

523.0

Repeat

Note=TPR 3

Tgene

TTC39C

chr18:20979530

chr18:21694518

ENST00000317571

353_386

328

584.0

Repeat

Note=TPR 2

Tgene

TTC39C

chr18:20979530

chr18:21694518

ENST00000317571

485_518

328

584.0

Repeat

Note=TPR 3

Tgene

TTC39C

chr18:20979530

chr18:21694518

ENST00000584250

315_348

77.0

Repeat

Note=TPR 1

Tgene

TTC39C

chr18:20979530

chr18:21694518

ENST00000584250

353_386

77.0

Repeat

Note=TPR 2

Tgene

TTC39C

chr18:20979530

chr18:21694518

ENST00000584250

485_518

77.0

Repeat

Note=TPR 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000383233

121_141

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000383233

146_166

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000383233

187_207

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000383233

211_231

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000383233

250_270

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000383233

271_291

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000383233

93_113

297.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000399707

121_141

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000399707

146_166

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000399707

187_207

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000399707

211_231

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000399707

250_270

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000399707

271_291

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000399707

67_87

124.0

Transmembrane

Helical

Hgene

TMEM241

chr18:20979530

chr18:21694518

ENST00000399707

93_113

124.0

Transmembrane

Helical

Tgene

TTC39C

chr18:20979530

chr18:21694518

ENST00000304621

19_25

267

523.0

Compositional bias

Note=Poly-Ala

Tgene

TTC39C

chr18:20979530

chr18:21694518

ENST00000317571

19_25

328

584.0

Compositional bias

Note=Poly-Ala

Tgene

TTC39C

chr18:20979530

chr18:21694518

ENST00000317571

315_348

328

584.0

Repeat

Note=TPR 1

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Fusion Gene Sequence for TMEM241-TTC39C

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>91970_91970_1_TMEM241-TTC39C_TMEM241_chr18_20979530_ENST00000383233_TTC39C_chr18_21694518_ENST00000304621_length(transcript)=1553nt_BP=332nt
CCAGGGGATTTGGGCAGGCACCGTGGATCCCCGAGAAGGGGACGAGTTGACAGATGTGCGTGAGGAGGTCTCTGGTCGGCCTCACCTTTT
GTACCTGCTACCTGGCTTCTTACCTCACGAACAAGTATGTGCTGTCTGTCTTGAAATTTACCTACCCTACATTATTCCAAGGGTGGCAGA
CGCTCATTGGTGGACTTTTGCTTCATGTGTCCTGGAAACTGGGCTGGGTAGAGATCAACAGCAGTTCAAGATCTCATGTTCTTGTGTGGC
TTCCTGCTTCAGTGCTGTTTGTGGGTATAATCTATGCTGGGTCCAGAGCATTGTCCAGACTGTGTCAAATCAACAGTGCCTTGACATCTT
TCCACACTGCTTTGGAACTTGCAGTAGACCAGAGAGAAATTCAACATGTCTGTCTGTATGAAATTGGTTGGTGCAGCATGATAGAGCTCA
ATTTCAAGGATGCATTTGATTCCTTTGAGAGGCTAAAAAATGAGTCCAGGTGGTCCCAGTGCTATTATGCCTACTTGACTGCAGTTTGTC
AGGGAGCCACTGGTGATGTGGATGGGGCACAGATTGTCTTTAAAGAAGTTCAGAAACTCTTCAAAAGGAAAAACAATCAGATTGAACAGT
TCTCGGTGAAAAAGGCAGAGCGATTTCGGAAGCAAACCCCAACCAAAGCGCTCTGTGTGTTGGCGTCTATTGAAGTGTTGTACTTGTGGA
AAGCTCTTCCAAACTGTTCCTTCCCCAACCTGCAGAGGATGAGTCAAGCTTGCCATGAAGTGGATGACTCATCTGTTGTTGGATTAAAGT
ATTTGCTTCTTGGTGCCATACACAAATGTCTAGGAAACTCAGAAGATGCTGTTCAGTACTTCCAGCGAGCTGTTAAAGATGAATTGTGTC
GTCAGAATAACTTATATGTTCAGCCGTATGCCTGTTATGAACTTGGCTGTCTTCTATTAGACAAACCAGAGACTGTAGGAAGAGGCAGAG
CTCTACTTCTTCAAGCAAAGGAGGATTTCTCTGGCTACGACTTTGAAAACAGATTGCATGTCCGCATCCATGCTGCTCTGGCCTCTCTGA
GGGAATTGGTTCCTCAGTGACAGACCCGGAACACCCGCTCCGTCCCTCCCCACCCAGGGTCCGCACTTTAAAATAAAAGCAGAGGACAAA
GCTCTTGTGAAGATGGGCTTTTCTTCTGAAAACCACCTGTGCCAGGGACACATTTTCCCAGTTAAGCTGACATATTAAAGATCTCCTCTT
TTAAACATGTAGCTGAAAAGTAATAATGATGTTGAGGAGGATGATGATGGTAATAATAACTAACCACCTGGGGAGAGGGTTAAGTGACCT
TGCTCAAACGTTTTAGTTTTGTGATTTATTATTTTTAAAATAAAATCAAACGGAACATCCAACCCAAGATCCTGTAGGAACACCTACCTT
AAGCACATATCTGAATGGGTAACATGATGAGGTACCTGTAAAATTATTAACAATATCATGACATAGCATTTATATTTGTGTTTTGAAAAA

>91970_91970_1_TMEM241-TTC39C_TMEM241_chr18_20979530_ENST00000383233_TTC39C_chr18_21694518_ENST00000304621_length(amino acids)=348AA_BP=93
MCVRRSLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLIGGLLLHVSWKLGWVEINSSSRSHVLVWLPASVLFVGIIYAGSRAL
SRLCQINSALTSFHTALELAVDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTAVCQGATGDVDGAQIVFKEVQ
KLFKRKNNQIEQFSVKKAERFRKQTPTKALCVLASIEVLYLWKALPNCSFPNLQRMSQACHEVDDSSVVGLKYLLLGAIHKCLGNSEDAV

--------------------------------------------------------------
>91970_91970_2_TMEM241-TTC39C_TMEM241_chr18_20979530_ENST00000383233_TTC39C_chr18_21694518_ENST00000317571_length(transcript)=1554nt_BP=332nt
CCAGGGGATTTGGGCAGGCACCGTGGATCCCCGAGAAGGGGACGAGTTGACAGATGTGCGTGAGGAGGTCTCTGGTCGGCCTCACCTTTT
GTACCTGCTACCTGGCTTCTTACCTCACGAACAAGTATGTGCTGTCTGTCTTGAAATTTACCTACCCTACATTATTCCAAGGGTGGCAGA
CGCTCATTGGTGGACTTTTGCTTCATGTGTCCTGGAAACTGGGCTGGGTAGAGATCAACAGCAGTTCAAGATCTCATGTTCTTGTGTGGC
TTCCTGCTTCAGTGCTGTTTGTGGGTATAATCTATGCTGGGTCCAGAGCATTGTCCAGACTGTGTCAAATCAACAGTGCCTTGACATCTT
TCCACACTGCTTTGGAACTTGCAGTAGACCAGAGAGAAATTCAACATGTCTGTCTGTATGAAATTGGTTGGTGCAGCATGATAGAGCTCA
ATTTCAAGGATGCATTTGATTCCTTTGAGAGGCTAAAAAATGAGTCCAGGTGGTCCCAGTGCTATTATGCCTACTTGACTGCAGTTTGTC
AGGGAGCCACTGGTGATGTGGATGGGGCACAGATTGTCTTTAAAGAAGTTCAGAAACTCTTCAAAAGGAAAAACAATCAGATTGAACAGT
TCTCGGTGAAAAAGGCAGAGCGATTTCGGAAGCAAACCCCAACCAAAGCGCTCTGTGTGTTGGCGTCTATTGAAGTGTTGTACTTGTGGA
AAGCTCTTCCAAACTGTTCCTTCCCCAACCTGCAGAGGATGAGTCAAGCTTGCCATGAAGTGGATGACTCATCTGTTGTTGGATTAAAGT
ATTTGCTTCTTGGTGCCATACACAAATGTCTAGGAAACTCAGAAGATGCTGTTCAGTACTTCCAGCGAGCTGTTAAAGATGAATTGTGTC
GTCAGAATAACTTATATGTTCAGCCGTATGCCTGTTATGAACTTGGCTGTCTTCTATTAGACAAACCAGAGACTGTAGGAAGAGGCAGAG
CTCTACTTCTTCAAGCAAAGGAGGATTTCTCTGGCTACGACTTTGAAAACAGATTGCATGTCCGCATCCATGCTGCTCTGGCCTCTCTGA
GGGAATTGGTTCCTCAGTGACAGACCCGGAACACCCGCTCCGTCCCTCCCCACCCAGGGTCCGCACTTTAAAATAAAAGCAGAGGACAAA
GCTCTTGTGAAGATGGGCTTTTCTTCTGAAAACCACCTGTGCCAGGGACACATTTTCCCAGTTAAGCTGACATATTAAAGATCTCCTCTT
TTAAACATGTAGCTGAAAAGTAATAATGATGTTGAGGAGGATGATGATGGTAATAATAACTAACCACCTGGGGAGAGGGTTAAGTGACCT
TGCTCAAACGTTTTAGTTTTGTGATTTATTATTTTTAAAATAAAATCAAACGGAACATCCAACCCAAGATCCTGTAGGAACACCTACCTT
AAGCACATATCTGAATGGGTAACATGATGAGGTACCTGTAAAATTATTAACAATATCATGACATAGCATTTATATTTGTGTTTTGAAAAA

>91970_91970_2_TMEM241-TTC39C_TMEM241_chr18_20979530_ENST00000383233_TTC39C_chr18_21694518_ENST00000317571_length(amino acids)=348AA_BP=93
MCVRRSLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLIGGLLLHVSWKLGWVEINSSSRSHVLVWLPASVLFVGIIYAGSRAL
SRLCQINSALTSFHTALELAVDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTAVCQGATGDVDGAQIVFKEVQ
KLFKRKNNQIEQFSVKKAERFRKQTPTKALCVLASIEVLYLWKALPNCSFPNLQRMSQACHEVDDSSVVGLKYLLLGAIHKCLGNSEDAV

--------------------------------------------------------------
>91970_91970_3_TMEM241-TTC39C_TMEM241_chr18_20979530_ENST00000399707_TTC39C_chr18_21694518_ENST00000304621_length(transcript)=1531nt_BP=310nt
GTCTCTGGGCGGCTGCTGCCGCTGCCGCTGCTGCTGCTGCGGGGGTCGGGCGGCGGCCAGGGGATTTGGGCAGGCACCGTGGATCCCCGA
GAAGGGGACGAGTTGACAGATGTGCGTGAGGAGGTCTCTGGTCGGCCTCACCTTTTGTACCTGCTACCTGGCTTCTTACCTCACGAACAA
GTATGTGCTGTCTGTCTTGAAATTTACCTACCCTACATTATTCCAAGGATCTCATGTTCTTGTGTGGCTTCCTGCTTCAGTGCTGTTTGT
GGGTATAATCTATGCTGGGTCCAGAGCATTGTCCAGACTGTGTCAAATCAACAGTGCCTTGACATCTTTCCACACTGCTTTGGAACTTGC
AGTAGACCAGAGAGAAATTCAACATGTCTGTCTGTATGAAATTGGTTGGTGCAGCATGATAGAGCTCAATTTCAAGGATGCATTTGATTC
CTTTGAGAGGCTAAAAAATGAGTCCAGGTGGTCCCAGTGCTATTATGCCTACTTGACTGCAGTTTGTCAGGGAGCCACTGGTGATGTGGA
TGGGGCACAGATTGTCTTTAAAGAAGTTCAGAAACTCTTCAAAAGGAAAAACAATCAGATTGAACAGTTCTCGGTGAAAAAGGCAGAGCG
ATTTCGGAAGCAAACCCCAACCAAAGCGCTCTGTGTGTTGGCGTCTATTGAAGTGTTGTACTTGTGGAAAGCTCTTCCAAACTGTTCCTT
CCCCAACCTGCAGAGGATGAGTCAAGCTTGCCATGAAGTGGATGACTCATCTGTTGTTGGATTAAAGTATTTGCTTCTTGGTGCCATACA
CAAATGTCTAGGAAACTCAGAAGATGCTGTTCAGTACTTCCAGCGAGCTGTTAAAGATGAATTGTGTCGTCAGAATAACTTATATGTTCA
GCCGTATGCCTGTTATGAACTTGGCTGTCTTCTATTAGACAAACCAGAGACTGTAGGAAGAGGCAGAGCTCTACTTCTTCAAGCAAAGGA
GGATTTCTCTGGCTACGACTTTGAAAACAGATTGCATGTCCGCATCCATGCTGCTCTGGCCTCTCTGAGGGAATTGGTTCCTCAGTGACA
GACCCGGAACACCCGCTCCGTCCCTCCCCACCCAGGGTCCGCACTTTAAAATAAAAGCAGAGGACAAAGCTCTTGTGAAGATGGGCTTTT
CTTCTGAAAACCACCTGTGCCAGGGACACATTTTCCCAGTTAAGCTGACATATTAAAGATCTCCTCTTTTAAACATGTAGCTGAAAAGTA
ATAATGATGTTGAGGAGGATGATGATGGTAATAATAACTAACCACCTGGGGAGAGGGTTAAGTGACCTTGCTCAAACGTTTTAGTTTTGT
GATTTATTATTTTTAAAATAAAATCAAACGGAACATCCAACCCAAGATCCTGTAGGAACACCTACCTTAAGCACATATCTGAATGGGTAA
CATGATGAGGTACCTGTAAAATTATTAACAATATCATGACATAGCATTTATATTTGTGTTTTGAAAAAATAAAAGTGCTTTCTAGTGTTT

>91970_91970_3_TMEM241-TTC39C_TMEM241_chr18_20979530_ENST00000399707_TTC39C_chr18_21694518_ENST00000304621_length(amino acids)=322AA_BP=67
MCVRRSLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGSHVLVWLPASVLFVGIIYAGSRALSRLCQINSALTSFHTALELAVDQREI
QHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTAVCQGATGDVDGAQIVFKEVQKLFKRKNNQIEQFSVKKAERFRKQTP
TKALCVLASIEVLYLWKALPNCSFPNLQRMSQACHEVDDSSVVGLKYLLLGAIHKCLGNSEDAVQYFQRAVKDELCRQNNLYVQPYACYE

--------------------------------------------------------------
>91970_91970_4_TMEM241-TTC39C_TMEM241_chr18_20979530_ENST00000399707_TTC39C_chr18_21694518_ENST00000317571_length(transcript)=1532nt_BP=310nt
GTCTCTGGGCGGCTGCTGCCGCTGCCGCTGCTGCTGCTGCGGGGGTCGGGCGGCGGCCAGGGGATTTGGGCAGGCACCGTGGATCCCCGA
GAAGGGGACGAGTTGACAGATGTGCGTGAGGAGGTCTCTGGTCGGCCTCACCTTTTGTACCTGCTACCTGGCTTCTTACCTCACGAACAA
GTATGTGCTGTCTGTCTTGAAATTTACCTACCCTACATTATTCCAAGGATCTCATGTTCTTGTGTGGCTTCCTGCTTCAGTGCTGTTTGT
GGGTATAATCTATGCTGGGTCCAGAGCATTGTCCAGACTGTGTCAAATCAACAGTGCCTTGACATCTTTCCACACTGCTTTGGAACTTGC
AGTAGACCAGAGAGAAATTCAACATGTCTGTCTGTATGAAATTGGTTGGTGCAGCATGATAGAGCTCAATTTCAAGGATGCATTTGATTC
CTTTGAGAGGCTAAAAAATGAGTCCAGGTGGTCCCAGTGCTATTATGCCTACTTGACTGCAGTTTGTCAGGGAGCCACTGGTGATGTGGA
TGGGGCACAGATTGTCTTTAAAGAAGTTCAGAAACTCTTCAAAAGGAAAAACAATCAGATTGAACAGTTCTCGGTGAAAAAGGCAGAGCG
ATTTCGGAAGCAAACCCCAACCAAAGCGCTCTGTGTGTTGGCGTCTATTGAAGTGTTGTACTTGTGGAAAGCTCTTCCAAACTGTTCCTT
CCCCAACCTGCAGAGGATGAGTCAAGCTTGCCATGAAGTGGATGACTCATCTGTTGTTGGATTAAAGTATTTGCTTCTTGGTGCCATACA
CAAATGTCTAGGAAACTCAGAAGATGCTGTTCAGTACTTCCAGCGAGCTGTTAAAGATGAATTGTGTCGTCAGAATAACTTATATGTTCA
GCCGTATGCCTGTTATGAACTTGGCTGTCTTCTATTAGACAAACCAGAGACTGTAGGAAGAGGCAGAGCTCTACTTCTTCAAGCAAAGGA
GGATTTCTCTGGCTACGACTTTGAAAACAGATTGCATGTCCGCATCCATGCTGCTCTGGCCTCTCTGAGGGAATTGGTTCCTCAGTGACA
GACCCGGAACACCCGCTCCGTCCCTCCCCACCCAGGGTCCGCACTTTAAAATAAAAGCAGAGGACAAAGCTCTTGTGAAGATGGGCTTTT
CTTCTGAAAACCACCTGTGCCAGGGACACATTTTCCCAGTTAAGCTGACATATTAAAGATCTCCTCTTTTAAACATGTAGCTGAAAAGTA
ATAATGATGTTGAGGAGGATGATGATGGTAATAATAACTAACCACCTGGGGAGAGGGTTAAGTGACCTTGCTCAAACGTTTTAGTTTTGT
GATTTATTATTTTTAAAATAAAATCAAACGGAACATCCAACCCAAGATCCTGTAGGAACACCTACCTTAAGCACATATCTGAATGGGTAA
CATGATGAGGTACCTGTAAAATTATTAACAATATCATGACATAGCATTTATATTTGTGTTTTGAAAAAATAAAAGTGCTTTCTAGTGTTT

>91970_91970_4_TMEM241-TTC39C_TMEM241_chr18_20979530_ENST00000399707_TTC39C_chr18_21694518_ENST00000317571_length(amino acids)=322AA_BP=67
MCVRRSLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGSHVLVWLPASVLFVGIIYAGSRALSRLCQINSALTSFHTALELAVDQREI
QHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTAVCQGATGDVDGAQIVFKEVQKLFKRKNNQIEQFSVKKAERFRKQTP
TKALCVLASIEVLYLWKALPNCSFPNLQRMSQACHEVDDSSVVGLKYLLLGAIHKCLGNSEDAVQYFQRAVKDELCRQNNLYVQPYACYE

--------------------------------------------------------------
>91970_91970_5_TMEM241-TTC39C_TMEM241_chr18_20979530_ENST00000542162_TTC39C_chr18_21694518_ENST00000304621_length(transcript)=1501nt_BP=280nt
GATGTGCGTGAGGAGGTCTCTGGTCGGCCTCACCTTTTGTACCTGCTACCTGGCTTCTTACCTCACGAACAAGTATGTGCTGTCTGTCTT
GAAATTTACCTACCCTACATTATTCCAAGGGTGGCAGACGCTCATTGGTGGACTTTTGCTTCATGTGTCCTGGAAACTGGGCTGGGTAGA
GATCAACAGCAGTTCAAGATCTCATGTTCTTGTGTGGCTTCCTGCTTCAGTGCTGTTTGTGGGTATAATCTATGCTGGGTCCAGAGCATT
GTCCAGACTGTGTCAAATCAACAGTGCCTTGACATCTTTCCACACTGCTTTGGAACTTGCAGTAGACCAGAGAGAAATTCAACATGTCTG
TCTGTATGAAATTGGTTGGTGCAGCATGATAGAGCTCAATTTCAAGGATGCATTTGATTCCTTTGAGAGGCTAAAAAATGAGTCCAGGTG
GTCCCAGTGCTATTATGCCTACTTGACTGCAGTTTGTCAGGGAGCCACTGGTGATGTGGATGGGGCACAGATTGTCTTTAAAGAAGTTCA
GAAACTCTTCAAAAGGAAAAACAATCAGATTGAACAGTTCTCGGTGAAAAAGGCAGAGCGATTTCGGAAGCAAACCCCAACCAAAGCGCT
CTGTGTGTTGGCGTCTATTGAAGTGTTGTACTTGTGGAAAGCTCTTCCAAACTGTTCCTTCCCCAACCTGCAGAGGATGAGTCAAGCTTG
CCATGAAGTGGATGACTCATCTGTTGTTGGATTAAAGTATTTGCTTCTTGGTGCCATACACAAATGTCTAGGAAACTCAGAAGATGCTGT
TCAGTACTTCCAGCGAGCTGTTAAAGATGAATTGTGTCGTCAGAATAACTTATATGTTCAGCCGTATGCCTGTTATGAACTTGGCTGTCT
TCTATTAGACAAACCAGAGACTGTAGGAAGAGGCAGAGCTCTACTTCTTCAAGCAAAGGAGGATTTCTCTGGCTACGACTTTGAAAACAG
ATTGCATGTCCGCATCCATGCTGCTCTGGCCTCTCTGAGGGAATTGGTTCCTCAGTGACAGACCCGGAACACCCGCTCCGTCCCTCCCCA
CCCAGGGTCCGCACTTTAAAATAAAAGCAGAGGACAAAGCTCTTGTGAAGATGGGCTTTTCTTCTGAAAACCACCTGTGCCAGGGACACA
TTTTCCCAGTTAAGCTGACATATTAAAGATCTCCTCTTTTAAACATGTAGCTGAAAAGTAATAATGATGTTGAGGAGGATGATGATGGTA
ATAATAACTAACCACCTGGGGAGAGGGTTAAGTGACCTTGCTCAAACGTTTTAGTTTTGTGATTTATTATTTTTAAAATAAAATCAAACG
GAACATCCAACCCAAGATCCTGTAGGAACACCTACCTTAAGCACATATCTGAATGGGTAACATGATGAGGTACCTGTAAAATTATTAACA

>91970_91970_5_TMEM241-TTC39C_TMEM241_chr18_20979530_ENST00000542162_TTC39C_chr18_21694518_ENST00000304621_length(amino acids)=348AA_BP=93
MCVRRSLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLIGGLLLHVSWKLGWVEINSSSRSHVLVWLPASVLFVGIIYAGSRAL
SRLCQINSALTSFHTALELAVDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTAVCQGATGDVDGAQIVFKEVQ
KLFKRKNNQIEQFSVKKAERFRKQTPTKALCVLASIEVLYLWKALPNCSFPNLQRMSQACHEVDDSSVVGLKYLLLGAIHKCLGNSEDAV

--------------------------------------------------------------
>91970_91970_6_TMEM241-TTC39C_TMEM241_chr18_20979530_ENST00000542162_TTC39C_chr18_21694518_ENST00000317571_length(transcript)=1502nt_BP=280nt
GATGTGCGTGAGGAGGTCTCTGGTCGGCCTCACCTTTTGTACCTGCTACCTGGCTTCTTACCTCACGAACAAGTATGTGCTGTCTGTCTT
GAAATTTACCTACCCTACATTATTCCAAGGGTGGCAGACGCTCATTGGTGGACTTTTGCTTCATGTGTCCTGGAAACTGGGCTGGGTAGA
GATCAACAGCAGTTCAAGATCTCATGTTCTTGTGTGGCTTCCTGCTTCAGTGCTGTTTGTGGGTATAATCTATGCTGGGTCCAGAGCATT
GTCCAGACTGTGTCAAATCAACAGTGCCTTGACATCTTTCCACACTGCTTTGGAACTTGCAGTAGACCAGAGAGAAATTCAACATGTCTG
TCTGTATGAAATTGGTTGGTGCAGCATGATAGAGCTCAATTTCAAGGATGCATTTGATTCCTTTGAGAGGCTAAAAAATGAGTCCAGGTG
GTCCCAGTGCTATTATGCCTACTTGACTGCAGTTTGTCAGGGAGCCACTGGTGATGTGGATGGGGCACAGATTGTCTTTAAAGAAGTTCA
GAAACTCTTCAAAAGGAAAAACAATCAGATTGAACAGTTCTCGGTGAAAAAGGCAGAGCGATTTCGGAAGCAAACCCCAACCAAAGCGCT
CTGTGTGTTGGCGTCTATTGAAGTGTTGTACTTGTGGAAAGCTCTTCCAAACTGTTCCTTCCCCAACCTGCAGAGGATGAGTCAAGCTTG
CCATGAAGTGGATGACTCATCTGTTGTTGGATTAAAGTATTTGCTTCTTGGTGCCATACACAAATGTCTAGGAAACTCAGAAGATGCTGT
TCAGTACTTCCAGCGAGCTGTTAAAGATGAATTGTGTCGTCAGAATAACTTATATGTTCAGCCGTATGCCTGTTATGAACTTGGCTGTCT
TCTATTAGACAAACCAGAGACTGTAGGAAGAGGCAGAGCTCTACTTCTTCAAGCAAAGGAGGATTTCTCTGGCTACGACTTTGAAAACAG
ATTGCATGTCCGCATCCATGCTGCTCTGGCCTCTCTGAGGGAATTGGTTCCTCAGTGACAGACCCGGAACACCCGCTCCGTCCCTCCCCA
CCCAGGGTCCGCACTTTAAAATAAAAGCAGAGGACAAAGCTCTTGTGAAGATGGGCTTTTCTTCTGAAAACCACCTGTGCCAGGGACACA
TTTTCCCAGTTAAGCTGACATATTAAAGATCTCCTCTTTTAAACATGTAGCTGAAAAGTAATAATGATGTTGAGGAGGATGATGATGGTA
ATAATAACTAACCACCTGGGGAGAGGGTTAAGTGACCTTGCTCAAACGTTTTAGTTTTGTGATTTATTATTTTTAAAATAAAATCAAACG
GAACATCCAACCCAAGATCCTGTAGGAACACCTACCTTAAGCACATATCTGAATGGGTAACATGATGAGGTACCTGTAAAATTATTAACA

>91970_91970_6_TMEM241-TTC39C_TMEM241_chr18_20979530_ENST00000542162_TTC39C_chr18_21694518_ENST00000317571_length(amino acids)=348AA_BP=93
MCVRRSLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLIGGLLLHVSWKLGWVEINSSSRSHVLVWLPASVLFVGIIYAGSRAL
SRLCQINSALTSFHTALELAVDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTAVCQGATGDVDGAQIVFKEVQ
KLFKRKNNQIEQFSVKKAERFRKQTPTKALCVLASIEVLYLWKALPNCSFPNLQRMSQACHEVDDSSVVGLKYLLLGAIHKCLGNSEDAV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TMEM241-TTC39C

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TMEM241-TTC39C

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TMEM241-TTC39C

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source