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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMEM254-CREB3L3 (FusionGDB2 ID:92006)

Fusion Gene Summary for TMEM254-CREB3L3

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM254-CREB3L3
	Fusion gene ID: 92006
		Hgene	Tgene
	Gene symbol	TMEM254	CREB3L3
	Gene ID	80195	84699
	Gene name	transmembrane protein 254	cAMP responsive element binding protein 3 like 3
	Synonyms	C10orf57\|bA369J21.6	CREB-H\|CREBH\|HYST1481
	Cytomap	10q22.3	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 254transmembrane protein C10orf57	cyclic AMP-responsive element-binding protein 3-like protein 3CREB/ATF family transcription factorcAMP-responsive element-binding protein, hepatic-specific
	Modification date	20200313	20200313
	UniProtAcc	Q8TBM7	Q68CJ9
	Ensembl transtripts involved in fusion gene	ENST00000467529, ENST00000372274, ENST00000372275, ENST00000372277, ENST00000372281,	ENST00000078445, ENST00000252587, ENST00000595923, ENST00000602147, ENST00000602257,
Fusion gene scores	* DoF score	4 X 3 X 3=36	6 X 7 X 6=252
	# samples	4	7
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TMEM254 [Title/Abstract] AND CREB3L3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM254(81841960)-CREB3L3(4170137), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CREB3L3	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	16469704

Fusion gene breakpoints across TMEM254 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CREB3L3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E2-A106-01A	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+

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Fusion Gene ORF analysis for TMEM254-CREB3L3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000467529	ENST00000078445	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
3UTR-intron	ENST00000467529	ENST00000252587	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
3UTR-intron	ENST00000467529	ENST00000595923	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
3UTR-intron	ENST00000467529	ENST00000602147	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
3UTR-intron	ENST00000467529	ENST00000602257	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372274	ENST00000252587	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372274	ENST00000595923	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372274	ENST00000602147	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372274	ENST00000602257	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372275	ENST00000252587	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372275	ENST00000595923	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372275	ENST00000602147	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372275	ENST00000602257	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372277	ENST00000252587	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372277	ENST00000595923	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372277	ENST00000602147	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372277	ENST00000602257	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372281	ENST00000252587	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372281	ENST00000595923	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372281	ENST00000602147	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
5CDS-intron	ENST00000372281	ENST00000602257	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
In-frame	ENST00000372274	ENST00000078445	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
In-frame	ENST00000372275	ENST00000078445	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
In-frame	ENST00000372277	ENST00000078445	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+
In-frame	ENST00000372281	ENST00000078445	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000372277

TMEM254

chr10

81841960

ENST00000078445

CREB3L3

chr19

4170137

1931

281

1878

913

321

ENST00000372281

TMEM254

chr10

81841960

ENST00000078445

CREB3L3

chr19

4170137

1931

281

1878

913

321

ENST00000372275

TMEM254

chr10

81841960

ENST00000078445

CREB3L3

chr19

4170137

1919

269

1866

901

321

ENST00000372274

TMEM254

chr10

81841960

ENST00000078445

CREB3L3

chr19

4170137

1909

259

1856

891

321

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000372277	ENST00000078445	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+	0.16090144	0.8390986
ENST00000372281	ENST00000078445	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+	0.16090144	0.8390986
ENST00000372275	ENST00000078445	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+	0.166113	0.833887
ENST00000372274	ENST00000078445	TMEM254	chr10	81841960	+	CREB3L3	chr19	4170137	+	0.16778621	0.8322138

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Fusion Genomic Features for TMEM254-CREB3L3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TMEM254	chr10	81841960	+	CREB3L3	chr19	4170136	+	2.07E-07	0.99999976
TMEM254	chr10	81841960	+	CREB3L3	chr19	4170136	+	2.07E-07	0.99999976

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM254-CREB3L3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:81841960/chr19:4170137)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TMEM254 Q8TBM7	CREB3L3 Q68CJ9
	FUNCTION: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (By similarity). {ECO:0000250, ECO:0000250\|UniProtKB:Q91XE9, ECO:0000269\|PubMed:11353085, ECO:0000269\|PubMed:15800215, ECO:0000269\|PubMed:16469704}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM254

chr10:81841960

chr19:4170137

ENST00000372274

15_35

119.66666666666667

Transmembrane

Helical

Hgene

TMEM254

chr10:81841960

chr19:4170137

ENST00000372274

61_81

119.66666666666667

Transmembrane

Helical

Hgene

TMEM254

chr10:81841960

chr19:4170137

ENST00000372275

15_35

229.66666666666666

Transmembrane

Helical

Hgene

TMEM254

chr10:81841960

chr19:4170137

ENST00000372275

61_81

229.66666666666666

Transmembrane

Helical

Hgene

TMEM254

chr10:81841960

chr19:4170137

ENST00000372277

15_35

104.0

Transmembrane

Helical

Hgene

TMEM254

chr10:81841960

chr19:4170137

ENST00000372277

61_81

104.0

Transmembrane

Helical

Hgene

TMEM254

chr10:81841960

chr19:4170137

ENST00000372281

15_35

124.0

Transmembrane

Helical

Hgene

TMEM254

chr10:81841960

chr19:4170137

ENST00000372281

61_81

124.0

Transmembrane

Helical

Tgene

CREB3L3

chr10:81841960

chr19:4170137

ENST00000078445

285_306

273

462.0

Region

Leucine-zipper

Tgene

CREB3L3

chr10:81841960

chr19:4170137

ENST00000595923

285_306

272

461.0

Region

Leucine-zipper

Tgene

CREB3L3

chr10:81841960

chr19:4170137

ENST00000078445

344_461

273

462.0

Topological domain

Lumenal

Tgene

CREB3L3

chr10:81841960

chr19:4170137

ENST00000595923

344_461

272

461.0

Topological domain

Lumenal

Tgene

CREB3L3

chr10:81841960

chr19:4170137

ENST00000078445

323_343

273

462.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

CREB3L3

chr10:81841960

chr19:4170137

ENST00000595923

323_343

272

461.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM254

chr10:81841960

chr19:4170137

ENST00000372274

95_115

119.66666666666667

Transmembrane

Helical

Hgene

TMEM254

chr10:81841960

chr19:4170137

ENST00000372275

95_115

229.66666666666666

Transmembrane

Helical

Hgene

TMEM254

chr10:81841960

chr19:4170137

ENST00000372277

95_115

104.0

Transmembrane

Helical

Hgene

TMEM254

chr10:81841960

chr19:4170137

ENST00000372281

95_115

124.0

Transmembrane

Helical

Tgene

CREB3L3

chr10:81841960

chr19:4170137

ENST00000078445

243_306

273

462.0

Domain

bZIP

Tgene

CREB3L3

chr10:81841960

chr19:4170137

ENST00000595923

243_306

272

461.0

Domain

bZIP

Tgene

CREB3L3

chr10:81841960

chr19:4170137

ENST00000078445

245_274

273

462.0

Region

Basic motif

Tgene

CREB3L3

chr10:81841960

chr19:4170137

ENST00000595923

245_274

272

461.0

Region

Basic motif

Tgene

CREB3L3

chr10:81841960

chr19:4170137

ENST00000078445

1_322

273

462.0

Topological domain

Cytoplasmic

Tgene

CREB3L3

chr10:81841960

chr19:4170137

ENST00000595923

1_322

272

461.0

Topological domain

Cytoplasmic

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Fusion Gene Sequence for TMEM254-CREB3L3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>92006_92006_1_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372274_CREB3L3_chr19_4170137_ENST00000078445_length(transcript)=1909nt_BP=259nt
TTGCAGCCATGGCTACGGCAGCCGGCGCGACCTACTTTCAGCGAGGCAGTCTGTTCTGGTTCACAGTCATCACCCTCAGCTTTGGCTACT
ACACATGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCTTGGGCCCCTGGGCCCCTTCACTCAGTACTTGGTGGACCACCATC
ACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGTGGGAGAGTCCTTGTATGCCATAGTATTGTGCAAGATGTCAGCTT
GCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTCCAGG
CCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTCCCCT
CCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGATGCTG
CCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCAGGAA
GCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGGAATG
CAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCGGCGG
GAGACGAGCTGTGAGCCCCGCCAGGACTATGCTCCCAGGCCCCTCTGCCCAGGGGTGCCTTGGGGATGCTGCACTGGGCAGCTACCCACC
TGGGGATGGGACGTGAGGCCAAGACCCCAGCAGAGATGCCAGAATGGGGGAGGCACAGCTCATAGCCACACACCCAGGGCCTGACTGAGG
CCCACGCAGGAACCGACACTCAGACACAAGGCAAAGAGGGCCACAGGACCCGGGAAATACACACAGAGCCAGGAGCAGAAGCAAAGAGCA
GACACACATACAGCCTGAAACAGACCTGGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACACAGCCTGAAACAGACCCAGA
CAAACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACAGCCTGAAACAGACCCAGACACAGCCTGAAACAGATCCG
GACAGACAGACAGAAACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCT
GAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCTAGACAGACAGA
CACAGATTGAAACAGACCCAGACAAACAGACAGACACAGCCTGAAACAGACCCAGACACAGCCTGAAACAGACCCGGACAGACAGACAGA
CACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACCGACGCAGCCTGAAAGAGACCCAGA
CAGAGAGACAGGCAGACACAGCCTAAAACAGACCTGGACAGACAGGCAGACGTAGTCTGAAACAGACCTGAACAGACAGACAGACGCACA
CACACAACAGATGCGCAGCAACTCCCCGCCCAGGGACCCCTCCCGGCCTCCCTCGCACACTGGGAGGAGGAAGCCGCCGAGACTGCAGGG
AGCCTGGCCCCGGAGCCCCGGGTGCGCCCTGGTCTTTGGAGCAGCCACGGCCCACAATCACCCCCCTTTTCTAAGACTGCCTGATCCGAA

>92006_92006_1_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372274_CREB3L3_chr19_4170137_ENST00000078445_length(amino acids)=321AA_BP=88
MWAVAAPKTRAHPGLRGQAPCSLGGFLLPVCEGGREGSLGGELLRICCVCASVCLFRSVSDYVCLSVQVCFRLCLPVSLSGSLSGCVGLS
VWVCFRLCLSVCLGLFQAVSVCLSGSVSGCVWVCFRLCLSVCLGLFQSVSVCLGLFQAVSVCLSGSVSGCVCLSVRVCFRLCLSVCPGLF
QAVSVCLSGSVSGCFCLSVRICFRLCLGLFQAVCLSVWVCFRLCLSVCLSGSVSGCVCLSGSVSGCVCLSRSVSGCMCVCSLLLLLALCV

--------------------------------------------------------------
>92006_92006_2_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372275_CREB3L3_chr19_4170137_ENST00000078445_length(transcript)=1919nt_BP=269nt
CGGGGAGGTGTTGCAGCCATGGCTACGGCAGCCGGCGCGACCTACTTTCAGCGAGGCAGTCTGTTCTGGTTCACAGTCATCACCCTCAGC
TTTGGCTACTACACATGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCTTGGGCCCCTGGGCCCCTTCACTCAGTACTTGGTG
GACCACCATCACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGTGGGAGAGTCCTTGTATGCCATAGTATTGTGCAAG
ATGTCAGCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAG
AAACTCCAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATC
ATCCTCCCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCAC
AACGATGCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAG
TCTCCAGGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTC
CTGAGGAATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTG
GAGGCGGCGGGAGACGAGCTGTGAGCCCCGCCAGGACTATGCTCCCAGGCCCCTCTGCCCAGGGGTGCCTTGGGGATGCTGCACTGGGCA
GCTACCCACCTGGGGATGGGACGTGAGGCCAAGACCCCAGCAGAGATGCCAGAATGGGGGAGGCACAGCTCATAGCCACACACCCAGGGC
CTGACTGAGGCCCACGCAGGAACCGACACTCAGACACAAGGCAAAGAGGGCCACAGGACCCGGGAAATACACACAGAGCCAGGAGCAGAA
GCAAAGAGCAGACACACATACAGCCTGAAACAGACCTGGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACACAGCCTGAAA
CAGACCCAGACAAACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACAGCCTGAAACAGACCCAGACACAGCCTGA
AACAGATCCGGACAGACAGACAGAAACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACA
GACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCTA
GACAGACAGACACAGATTGAAACAGACCCAGACAAACAGACAGACACAGCCTGAAACAGACCCAGACACAGCCTGAAACAGACCCGGACA
GACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACCGACGCAGCCTGAAA
GAGACCCAGACAGAGAGACAGGCAGACACAGCCTAAAACAGACCTGGACAGACAGGCAGACGTAGTCTGAAACAGACCTGAACAGACAGA
CAGACGCACACACACAACAGATGCGCAGCAACTCCCCGCCCAGGGACCCCTCCCGGCCTCCCTCGCACACTGGGAGGAGGAAGCCGCCGA
GACTGCAGGGAGCCTGGCCCCGGAGCCCCGGGTGCGCCCTGGTCTTTGGAGCAGCCACGGCCCACAATCACCCCCCTTTTCTAAGACTGC

>92006_92006_2_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372275_CREB3L3_chr19_4170137_ENST00000078445_length(amino acids)=321AA_BP=88
MWAVAAPKTRAHPGLRGQAPCSLGGFLLPVCEGGREGSLGGELLRICCVCASVCLFRSVSDYVCLSVQVCFRLCLPVSLSGSLSGCVGLS
VWVCFRLCLSVCLGLFQAVSVCLSGSVSGCVWVCFRLCLSVCLGLFQSVSVCLGLFQAVSVCLSGSVSGCVCLSVRVCFRLCLSVCPGLF
QAVSVCLSGSVSGCFCLSVRICFRLCLGLFQAVCLSVWVCFRLCLSVCLSGSVSGCVCLSGSVSGCVCLSRSVSGCMCVCSLLLLLALCV

--------------------------------------------------------------
>92006_92006_3_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372277_CREB3L3_chr19_4170137_ENST00000078445_length(transcript)=1931nt_BP=281nt
GAAGCGCGCTCCCGGGGAGGTGTTGCAGCCATGGCTACGGCAGCCGGCGCGACCTACTTTCAGCGAGGCAGTCTGTTCTGGTTCACAGTC
ATCACCCTCAGCTTTGGCTACTACACATGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCTTGGGCCCCTGGGCCCCTTCACT
CAGTACTTGGTGGACCACCATCACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGTGGGAGAGTCCTTGTATGCCATA
GTATTGTGCAAGATGTCAGCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTG
GAGCAACTGAAGAAACTCCAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCC
TTTGCCCTCATCATCCTCCCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCC
AGAACTTTGCACAACGATGCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACA
ACCCGAGAAGAGTCTCCAGGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAAC
GCCACCCTGGTCCTGAGGAATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGA
CGTGCAGGGCTGGAGGCGGCGGGAGACGAGCTGTGAGCCCCGCCAGGACTATGCTCCCAGGCCCCTCTGCCCAGGGGTGCCTTGGGGATG
CTGCACTGGGCAGCTACCCACCTGGGGATGGGACGTGAGGCCAAGACCCCAGCAGAGATGCCAGAATGGGGGAGGCACAGCTCATAGCCA
CACACCCAGGGCCTGACTGAGGCCCACGCAGGAACCGACACTCAGACACAAGGCAAAGAGGGCCACAGGACCCGGGAAATACACACAGAG
CCAGGAGCAGAAGCAAAGAGCAGACACACATACAGCCTGAAACAGACCTGGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGA
CACAGCCTGAAACAGACCCAGACAAACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACAGCCTGAAACAGACCCA
GACACAGCCTGAAACAGATCCGGACAGACAGACAGAAACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCG
GACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCT
GAAACAGACCTAGACAGACAGACACAGATTGAAACAGACCCAGACAAACAGACAGACACAGCCTGAAACAGACCCAGACACAGCCTGAAA
CAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACCGA
CGCAGCCTGAAAGAGACCCAGACAGAGAGACAGGCAGACACAGCCTAAAACAGACCTGGACAGACAGGCAGACGTAGTCTGAAACAGACC
TGAACAGACAGACAGACGCACACACACAACAGATGCGCAGCAACTCCCCGCCCAGGGACCCCTCCCGGCCTCCCTCGCACACTGGGAGGA
GGAAGCCGCCGAGACTGCAGGGAGCCTGGCCCCGGAGCCCCGGGTGCGCCCTGGTCTTTGGAGCAGCCACGGCCCACAATCACCCCCCTT

>92006_92006_3_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372277_CREB3L3_chr19_4170137_ENST00000078445_length(amino acids)=321AA_BP=88
MWAVAAPKTRAHPGLRGQAPCSLGGFLLPVCEGGREGSLGGELLRICCVCASVCLFRSVSDYVCLSVQVCFRLCLPVSLSGSLSGCVGLS
VWVCFRLCLSVCLGLFQAVSVCLSGSVSGCVWVCFRLCLSVCLGLFQSVSVCLGLFQAVSVCLSGSVSGCVCLSVRVCFRLCLSVCPGLF
QAVSVCLSGSVSGCFCLSVRICFRLCLGLFQAVCLSVWVCFRLCLSVCLSGSVSGCVCLSGSVSGCVCLSRSVSGCMCVCSLLLLLALCV

--------------------------------------------------------------
>92006_92006_4_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372281_CREB3L3_chr19_4170137_ENST00000078445_length(transcript)=1931nt_BP=281nt
GAAGCGCGCTCCCGGGGAGGTGTTGCAGCCATGGCTACGGCAGCCGGCGCGACCTACTTTCAGCGAGGCAGTCTGTTCTGGTTCACAGTC
ATCACCCTCAGCTTTGGCTACTACACATGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCTTGGGCCCCTGGGCCCCTTCACT
CAGTACTTGGTGGACCACCATCACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGTGGGAGAGTCCTTGTATGCCATA
GTATTGTGCAAGATGTCAGCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTG
GAGCAACTGAAGAAACTCCAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCC
TTTGCCCTCATCATCCTCCCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCC
AGAACTTTGCACAACGATGCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACA
ACCCGAGAAGAGTCTCCAGGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAAC
GCCACCCTGGTCCTGAGGAATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGA
CGTGCAGGGCTGGAGGCGGCGGGAGACGAGCTGTGAGCCCCGCCAGGACTATGCTCCCAGGCCCCTCTGCCCAGGGGTGCCTTGGGGATG
CTGCACTGGGCAGCTACCCACCTGGGGATGGGACGTGAGGCCAAGACCCCAGCAGAGATGCCAGAATGGGGGAGGCACAGCTCATAGCCA
CACACCCAGGGCCTGACTGAGGCCCACGCAGGAACCGACACTCAGACACAAGGCAAAGAGGGCCACAGGACCCGGGAAATACACACAGAG
CCAGGAGCAGAAGCAAAGAGCAGACACACATACAGCCTGAAACAGACCTGGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGA
CACAGCCTGAAACAGACCCAGACAAACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACAGCCTGAAACAGACCCA
GACACAGCCTGAAACAGATCCGGACAGACAGACAGAAACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCG
GACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCT
GAAACAGACCTAGACAGACAGACACAGATTGAAACAGACCCAGACAAACAGACAGACACAGCCTGAAACAGACCCAGACACAGCCTGAAA
CAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACCGA
CGCAGCCTGAAAGAGACCCAGACAGAGAGACAGGCAGACACAGCCTAAAACAGACCTGGACAGACAGGCAGACGTAGTCTGAAACAGACC
TGAACAGACAGACAGACGCACACACACAACAGATGCGCAGCAACTCCCCGCCCAGGGACCCCTCCCGGCCTCCCTCGCACACTGGGAGGA
GGAAGCCGCCGAGACTGCAGGGAGCCTGGCCCCGGAGCCCCGGGTGCGCCCTGGTCTTTGGAGCAGCCACGGCCCACAATCACCCCCCTT

>92006_92006_4_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372281_CREB3L3_chr19_4170137_ENST00000078445_length(amino acids)=321AA_BP=88
MWAVAAPKTRAHPGLRGQAPCSLGGFLLPVCEGGREGSLGGELLRICCVCASVCLFRSVSDYVCLSVQVCFRLCLPVSLSGSLSGCVGLS
VWVCFRLCLSVCLGLFQAVSVCLSGSVSGCVWVCFRLCLSVCLGLFQSVSVCLGLFQAVSVCLSGSVSGCVCLSVRVCFRLCLSVCPGLF
QAVSVCLSGSVSGCFCLSVRICFRLCLGLFQAVCLSVWVCFRLCLSVCLSGSVSGCVCLSGSVSGCVCLSRSVSGCMCVCSLLLLLALCV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMEM254-CREB3L3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TMEM254-CREB3L3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TMEM254-CREB3L3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source