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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:TMEM2-HMCN1 (FusionGDB2 ID:92059) |
Fusion Gene Summary for TMEM2-HMCN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM2-HMCN1 | Fusion gene ID: 92059 | Hgene | Tgene | Gene symbol | TMEM2 | HMCN1 | Gene ID | 23670 | 83872 |
| Gene name | cell migration inducing hyaluronidase 2 | hemicentin 1 | |
| Synonyms | TMEM2 | ARMD1|FBLN6|FIBL-6|FIBL6 | |
| Cytomap | 9q21.13 | 1q25.3-q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cell surface hyaluronidasetransmembrane protein 2 | hemicentin-1LOC100507250/HMCN1 fusionfibulin-6 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q96RW7 | |
| Ensembl transtripts involved in fusion gene | ENST00000377044, ENST00000377066, ENST00000396272, | ENST00000485744, ENST00000271588, ENST00000367492, | |
| Fusion gene scores | * DoF score | 7 X 7 X 4=196 | 11 X 10 X 5=550 |
| # samples | 7 | 12 | |
| ** MAII score | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/550*10)=-2.1963972128035 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM2 [Title/Abstract] AND HMCN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | TMEM2(74309425)-HMCN1(185878469), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TMEM2 | GO:0030214 | hyaluronan catabolic process | 28246172 |
| Fusion gene breakpoints across TMEM2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across HMCN1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-DX-A48N-01A | TMEM2 | chr9 | 74309425 | - | HMCN1 | chr1 | 185878469 | + |
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Fusion Gene ORF analysis for TMEM2-HMCN1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000377044 | ENST00000485744 | TMEM2 | chr9 | 74309425 | - | HMCN1 | chr1 | 185878469 | + |
| 5CDS-intron | ENST00000377066 | ENST00000485744 | TMEM2 | chr9 | 74309425 | - | HMCN1 | chr1 | 185878469 | + |
| 5CDS-intron | ENST00000396272 | ENST00000485744 | TMEM2 | chr9 | 74309425 | - | HMCN1 | chr1 | 185878469 | + |
| Frame-shift | ENST00000377044 | ENST00000271588 | TMEM2 | chr9 | 74309425 | - | HMCN1 | chr1 | 185878469 | + |
| Frame-shift | ENST00000377044 | ENST00000367492 | TMEM2 | chr9 | 74309425 | - | HMCN1 | chr1 | 185878469 | + |
| Frame-shift | ENST00000377066 | ENST00000271588 | TMEM2 | chr9 | 74309425 | - | HMCN1 | chr1 | 185878469 | + |
| Frame-shift | ENST00000377066 | ENST00000367492 | TMEM2 | chr9 | 74309425 | - | HMCN1 | chr1 | 185878469 | + |
| In-frame | ENST00000396272 | ENST00000271588 | TMEM2 | chr9 | 74309425 | - | HMCN1 | chr1 | 185878469 | + |
| In-frame | ENST00000396272 | ENST00000367492 | TMEM2 | chr9 | 74309425 | - | HMCN1 | chr1 | 185878469 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000396272 | TMEM2 | chr9 | 74309425 | - | ENST00000271588 | HMCN1 | chr1 | 185878469 | + | 18198 | 840 | 165 | 17126 | 5653 |
| ENST00000396272 | TMEM2 | chr9 | 74309425 | - | ENST00000367492 | HMCN1 | chr1 | 185878469 | + | 17851 | 840 | 165 | 16775 | 5536 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000396272 | ENST00000271588 | TMEM2 | chr9 | 74309425 | - | HMCN1 | chr1 | 185878469 | + | 0.000251462 | 0.9997485 |
| ENST00000396272 | ENST00000367492 | TMEM2 | chr9 | 74309425 | - | HMCN1 | chr1 | 185878469 | + | 0.000599428 | 0.9994006 |
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Fusion Genomic Features for TMEM2-HMCN1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| TMEM2 | chr9 | 74309424 | - | HMCN1 | chr1 | 185878468 | + | 0.00044424 | 0.99955577 |
| TMEM2 | chr9 | 74309424 | - | HMCN1 | chr1 | 185878468 | + | 0.00044424 | 0.99955577 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TMEM2-HMCN1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:74309425/chr1:185878469) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | HMCN1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration. {ECO:0000250|UniProtKB:D3YXG0}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TMEM2 | chr9:74309425 | chr1:185878469 | ENST00000377044 | - | 21 | 24 | 121_245 | 1232 | 1384.0 | Domain | G8 |
| Hgene | TMEM2 | chr9:74309425 | chr1:185878469 | ENST00000377066 | - | 20 | 23 | 121_245 | 1169 | 1321.0 | Domain | G8 |
| Hgene | TMEM2 | chr9:74309425 | chr1:185878469 | ENST00000377044 | - | 21 | 24 | 669_691 | 1232 | 1384.0 | Repeat | Note=PbH1 1 |
| Hgene | TMEM2 | chr9:74309425 | chr1:185878469 | ENST00000377044 | - | 21 | 24 | 711_733 | 1232 | 1384.0 | Repeat | Note=PbH1 2 |
| Hgene | TMEM2 | chr9:74309425 | chr1:185878469 | ENST00000377044 | - | 21 | 24 | 791_812 | 1232 | 1384.0 | Repeat | Note=PbH1 3 |
| Hgene | TMEM2 | chr9:74309425 | chr1:185878469 | ENST00000377066 | - | 20 | 23 | 669_691 | 1169 | 1321.0 | Repeat | Note=PbH1 1 |
| Hgene | TMEM2 | chr9:74309425 | chr1:185878469 | ENST00000377066 | - | 20 | 23 | 711_733 | 1169 | 1321.0 | Repeat | Note=PbH1 2 |
| Hgene | TMEM2 | chr9:74309425 | chr1:185878469 | ENST00000377066 | - | 20 | 23 | 791_812 | 1169 | 1321.0 | Repeat | Note=PbH1 3 |
| Hgene | TMEM2 | chr9:74309425 | chr1:185878469 | ENST00000377044 | - | 21 | 24 | 1_82 | 1232 | 1384.0 | Topological domain | Cytoplasmic |
| Hgene | TMEM2 | chr9:74309425 | chr1:185878469 | ENST00000377066 | - | 20 | 23 | 1_82 | 1169 | 1321.0 | Topological domain | Cytoplasmic |
| Hgene | TMEM2 | chr9:74309425 | chr1:185878469 | ENST00000377044 | - | 21 | 24 | 83_103 | 1232 | 1384.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | TMEM2 | chr9:74309425 | chr1:185878469 | ENST00000377066 | - | 20 | 23 | 83_103 | 1169 | 1321.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 1072_1166 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 8 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 1171_1255 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 9 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 1262_1354 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 10 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 1358_1447 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 11 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 1452_1541 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 12 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 1546_1634 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 13 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 1638_1724 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 14 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 1733_1821 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 15 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 1826_1914 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 16 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 1919_2007 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 17 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 2012_2097 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 18 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 2104_2190 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 19 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 2195_2285 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 20 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 2290_2379 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 21 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 2384_2470 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 22 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 2478_2564 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 23 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 2571_2662 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 24 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 2666_2763 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 25 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 2766_2864 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 26 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 2868_2959 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 27 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 2964_3051 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 28 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 3056_3146 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 29 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 3151_3240 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 30 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 3245_3335 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 31 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 3340_3429 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 32 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 3434_3516 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 33 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 3527_3615 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 34 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 3620_3708 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 35 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 3713_3797 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 36 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 3804_3892 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 37 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 3897_3983 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 38 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 3988_4076 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 39 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 4079_4164 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 40 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 4169_4255 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 41 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 4260_4344 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 42 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 431_517 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 4348_4435 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 43 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 4440_4527 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 44 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 4529_4584 | 207 | 5636.0 | Domain | TSP type-1 1 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 4586_4641 | 207 | 5636.0 | Domain | TSP type-1 2 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 4643_4698 | 207 | 5636.0 | Domain | TSP type-1 3 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 4700_4755 | 207 | 5636.0 | Domain | TSP type-1 4 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 4757_4812 | 207 | 5636.0 | Domain | TSP type-1 5 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 4814_4869 | 207 | 5636.0 | Domain | TSP type-1 6 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 4871_5093 | 207 | 5636.0 | Domain | Nidogen G2 beta-barrel | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 5107_5146 | 207 | 5636.0 | Domain | EGF-like 1%3B calcium-binding | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 5147_5191 | 207 | 5636.0 | Domain | EGF-like 2%3B calcium-binding | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 5192_5229 | 207 | 5636.0 | Domain | EGF-like 3%3B calcium-binding | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 520_607 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 5230_5271 | 207 | 5636.0 | Domain | EGF-like 4%3B calcium-binding | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 5272_5307 | 207 | 5636.0 | Domain | EGF-like 5%3B calcium-binding | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 5315_5355 | 207 | 5636.0 | Domain | EGF-like 6%3B calcium-binding | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 5432_5471 | 207 | 5636.0 | Domain | EGF-like 7%3B calcium-binding | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 612_697 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 3 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 702_788 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 4 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 793_883 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 5 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 890_976 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 6 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 981_1067 | 207 | 5636.0 | Domain | Note=Ig-like C2-type 7 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 1072_1166 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 8 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 1171_1255 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 9 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 1262_1354 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 10 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 1358_1447 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 11 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 1452_1541 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 12 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 1546_1634 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 13 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 1638_1724 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 14 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 1733_1821 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 15 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 1826_1914 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 16 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 1919_2007 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 17 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 2012_2097 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 18 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 2104_2190 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 19 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 2195_2285 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 20 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 2290_2379 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 21 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 2384_2470 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 22 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 2478_2564 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 23 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 2571_2662 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 24 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 2666_2763 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 25 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 2766_2864 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 26 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 2868_2959 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 27 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 2964_3051 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 28 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 3056_3146 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 29 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 3151_3240 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 30 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 3245_3335 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 31 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 3340_3429 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 32 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 3434_3516 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 33 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 3527_3615 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 34 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 3620_3708 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 35 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 3713_3797 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 36 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 3804_3892 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 37 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 3897_3983 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 38 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 3988_4076 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 39 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 4079_4164 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 40 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 4169_4255 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 41 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 4260_4344 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 42 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 431_517 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 4348_4435 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 43 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 4440_4527 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 44 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 4529_4584 | 207 | 5519.0 | Domain | TSP type-1 1 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 4586_4641 | 207 | 5519.0 | Domain | TSP type-1 2 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 4643_4698 | 207 | 5519.0 | Domain | TSP type-1 3 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 4700_4755 | 207 | 5519.0 | Domain | TSP type-1 4 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 4757_4812 | 207 | 5519.0 | Domain | TSP type-1 5 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 4814_4869 | 207 | 5519.0 | Domain | TSP type-1 6 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 4871_5093 | 207 | 5519.0 | Domain | Nidogen G2 beta-barrel | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 5107_5146 | 207 | 5519.0 | Domain | EGF-like 1%3B calcium-binding | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 5147_5191 | 207 | 5519.0 | Domain | EGF-like 2%3B calcium-binding | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 5192_5229 | 207 | 5519.0 | Domain | EGF-like 3%3B calcium-binding | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 520_607 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 5230_5271 | 207 | 5519.0 | Domain | EGF-like 4%3B calcium-binding | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 5272_5307 | 207 | 5519.0 | Domain | EGF-like 5%3B calcium-binding | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 5315_5355 | 207 | 5519.0 | Domain | EGF-like 6%3B calcium-binding | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 5432_5471 | 207 | 5519.0 | Domain | EGF-like 7%3B calcium-binding | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 612_697 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 3 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 702_788 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 4 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 793_883 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 5 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 890_976 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 6 | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 981_1067 | 207 | 5519.0 | Domain | Note=Ig-like C2-type 7 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TMEM2 | chr9:74309425 | chr1:185878469 | ENST00000377044 | - | 21 | 24 | 104_1383 | 1232 | 1384.0 | Topological domain | Extracellular |
| Hgene | TMEM2 | chr9:74309425 | chr1:185878469 | ENST00000377066 | - | 20 | 23 | 104_1383 | 1169 | 1321.0 | Topological domain | Extracellular |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000271588 | 3 | 107 | 41_216 | 207 | 5636.0 | Domain | Note=VWFA | |
| Tgene | HMCN1 | chr9:74309425 | chr1:185878469 | ENST00000367492 | 3 | 106 | 41_216 | 207 | 5519.0 | Domain | Note=VWFA |
Top |
Fusion Gene Sequence for TMEM2-HMCN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >92059_92059_1_TMEM2-HMCN1_TMEM2_chr9_74309425_ENST00000396272_HMCN1_chr1_185878469_ENST00000271588_length(transcript)=18198nt_BP=840nt CACTTAGTCTGGCACAGATCACAGAATCTCCCTTTTCAAAGTTGAGACACTTGACTTTGTGCTGAAAATGTCTTTTTAGCTGTTTAAATT TTCATTCTCTTCCCTTTACTTCTTGATTATTTTTTCAAGGTCTATGTACAGACATGGAGCACTCAGAATCTTTCTATGACCATTACACGA GATGAGTATCCGTCCAACCCTATGGTGCTCCGAGGTATTAATCAGAAGGCTGCCTTTCCACAGTACCAGCCTGTCGTCATGCTGGAGAAG GGTTATACCATCCACTGGAATGGGCCGGCACCACGGACTACATTTCTATACCTCGTCAACTTCAACAAGAATGACTGGATTCGAGTTGGC CTTTGCTATCCATCAAACACAAGTTTTCAAGTTACCTTTGGCTATTTGCAGCGGCAGAATGGCTCATTATCCAAAATCGAAGAATATGAG CCTGTGCATTCACTGGAAGAACTGCAAAGAAAGCAATCCGAGAGGAAATTCTATTTTGACTCCAGCACGGGGTTACTGTTTTTGTATCTC AAAGCCAAAAGCCACAGGCATGGCCACAGTTACTGTTCATCTCAGGGATGTGAAAGAGTCAAGATCCAAGCAGCCACAGACTCAAAGGAC ATCAGTAACTGCATGGCCAAAGCATACCCACAGTACTACAGAAAGCCGTCAGTGGTCAAGCGGATGCCGGCCATGCTCACTGGACTCTGT CAAGGCTGTGGCACTCGGCAGGTGGTGTTTACTAGTGATCCTCATAAAAGTTACCTCCCTGTGCAATTCCAGTCACCTGATAAAGCAGAA ACCCAGCGTGGAGACCCGTCTGTTATTTCTGTATTAAAATGGGTAGAAGAAGCAGTACAGGCCTCCAAAGTTCACCTTTTATCCACAGAT CATTTGGAACAGGCTGTAAATACTTGGAGAATTCCTTTTGATCCCAGCCTGAAAGAGGTCACTGTGTCTTTGAGTGGGCCTTCTCCAATG ATTGAAATTCGCAATCCTTTAGGGAAGCTGATAAAAAAGGGATTTGGCCTGCATGAGCTATTAAATATCCATAACTCTGCCAAAGTAGTG AATGTGAAAGAGCCAGAGGCTGGAATGTGGACAGTGAAGACCTCAAGCAGTGGAAGGCACTCTGTTCGCATTACTGGCCTCAGTACTATT GATTTCCGAGCTGGCTTTTCTCGAAAGCCCACCCTGGACTTCAAAAAAACAGTCAGCAGACCAGTGCAAGGAATACCTACCTATGTACTG CTCAATACTTCTGGAATTTCCACTCCAGCTAGAATAGATCTTCTTGAACTTTTGAGTATCTCAGGAAGTTCTCTTAAGACTATTCCTGTT AAATATTACCCACATCGAAAACCTTATGGCATATGGAATATTTCTGACTTTGTACCACCAAATGAAGCTTTCTTTCTCAAAGTAACAGGC TATGATAAAGATGATTACCTCTTCCAGAGAGTATCAAGTGTTTCCTTTTCTAGTATTGTCCCAGATGCTCCCAAAGTTACGATGCCTGAG AAAACCCCAGGATACTATCTGCAGCCGGGCCAAATTCCCTGCTCTGTTGACAGTCTTTTGCCCTTTACCTTGAGCTTTGTCAGAAATGGA GTTACACTTGGAGTAGACCAGTATTTGAAAGAATCTGCCAGTGTGAACTTAGATATTGCAAAGGTCACTTTGTCTGACGAAGGTTTCTAT GAATGCATTGCTGTCAGCAGTGCAGGTACTGGACGGGCACAGACATTTTTTGACGTATCAGAGCCCCCTCCGGTCATCCAAGTGCCTAAC AATGTTACAGTCACTCCTGGAGAGAGAGCAGTTTTAACATGTCTCATCATCAGTGCGGTGGATTACAATCTAACCTGGCAGAGGAATGAC AGAGATGTCAGACTGGCAGAGCCAGCGAGAATTAGGACCTTGGCTAATCTGTCATTGGAGCTAAAGAGTGTGAAATTCAACGATGCTGGA GAGTATCATTGTATGGTTTCTAGTGAAGGTGGATCATCAGCCGCTTCAGTTTTCCTCACAGTGCAAGAACCACCCAAAGTCACTGTGATG CCCAAGAATCAGTCTTTCACAGGAGGGTCTGAGGTCTCCATCATGTGTTCTGCAACAGGTTATCCCAAACCAAAGATTGCCTGGACCGTT AACGATATGTTTATCGTGGGTTCACACAGGTATAGGATGACCTCAGATGGTACCTTATTTATCAAAAATGCAGCTCCCAAAGATGCAGGG ATCTATGGTTGCCTAGCAAGTAATTCAGCTGGAACAGATAAACAGAATTCTACTCTCAGATACATTGAAGCCCCTAAGTTGATGGTAGTT CAGAGTGAGCTCTTGGTTGCCCTTGGGGATATAACCGTTATGGAATGCAAAACCTCTGGTATTCCTCCACCTCAAGTTAAATGGTTCAAA GGAGATCTTGAGTTGAGGCCCTCAACATTCCTCATTATTGACCCTCTCTTGGGACTTTTGAAGATTCAAGAAACACAAGATCTGGATGCT GGCGATTATACCTGTGTAGCCATCAATGAGGCTGGAAGAGCAACTGGCAAGATAACTCTGGATGTTGGCTCACCTCCAGTTTTCATACAA GAACCTGCTGATGTGTCTATGGAAATTGGCTCAAATGTGACATTACCTTGTTATGTTCAGGGTTATCCAGAACCAACAATCAAATGGCGA AGATTAGACAACATGCCAATTTTCTCAAGACCTTTTTCAGTTAGTTCCATCAGCCAACTAAGAACAGGAGCTCTCTTTATTTTAAACTTA TGGGCAAGTGATAAAGGAACCTATATTTGTGAAGCTGAAAACCAGTTTGGAAAGATCCAGTCAGAGACAACAGTAACAGTGACCGGACTT GTTGCTCCACTTATTGGAATCAGCCCTTCAGTGGCCAATGTTATTGAAGGACAGCAGCTTACTTTGCCCTGTACTCTGTTAGCTGGAAAT CCCATTCCAGAACGTCGGTGGATTAAGAATTCAGCTATGTTGCTCCAAAATCCTTACATCACTGTGCGCAGTGATGGGAGCCTCCATATT GAAAGAGTTCAGCTTCAGGATGGTGGTGAATATACTTGTGTGGCCAGTAACGTTGCTGGGACCAATAACAAAACTACCTCTGTGGTTGTG CATGTTCTGCCAACCATTCAGCATGGGCAGCAGATACTCAGTACAATTGAAGGCATTCCAGTAACTTTACCATGCAAAGCAAGTGGAAAT CCCAAACCGTCTGTCATCTGGTCCAAGAAAGGAGAGCTGATTTCAACCAGCAGTGCTAAGTTTTCAGCAGGAGCTGATGGTAGTCTGTAT GTGGTATCACCTGGAGGAGAGGAGAGTGGGGAGTATGTCTGCACTGCCACCAATACAGCCGGCTACGCCAAAAGGAAAGTGCAGCTAACA GTCTATGTAAGGCCCAGAGTGTTTGGAGATCAACGAGGACTGTCCCAGGATAAGCCTGTTGAGATCTCCGTCCTTGCAGGGGAAGAGGTA ACACTTCCATGTGAAGTGAAGAGCTTACCTCCACCCATAATTACTTGGGCCAAAGAAACCCAGCTCATCTCACCGTTCTCTCCAAGACAC ACATTCCTCCCTTCTGGTTCAATGAAGATCACTGAAACCCGCACTTCAGATAGTGGGATGTATCTTTGTGTTGCCACAAATATTGCTGGG AATGTGACTCAGGCTGTCAAATTAAATGTCCATGTTCCTCCAAAGATACAGCGTGGACCTAAACATCTCAAAGTCCAAGTTGGTCAAAGA GTGGATATTCCATGTAATGCTCAAGGGACTCCTCTTCCTGTAATCACCTGGTCCAAAGGTGGAAGCACTATGCTGGTTGATGGAGAGCAC CATGTTAGCAATCCAGACGGAACTTTAAGCATCGACCAAGCCACGCCCTCAGATGCTGGCATATATACATGTGTTGCTACTAACATAGCA GGCACTGATGAAACAGAGATAACGCTACATGTCCAAGAACCACCCACAGTGGAAGATCTAGAACCTCCATATAACACTACTTTCCAAGAA AGAGTGGCCAATCAACGCATTGAATTTCCATGTCCTGCAAAAGGTACCCCTAAACCAACCATCAAATGGTTACACAATGGTAGAGAGTTG ACAGGCAGAGAGCCTGGCATTTCTATCTTGGAAGATGGCACATTGCTGGTTATTGCTTCTGTTACACCCTATGACAATGGGGAGTACATC TGTGTGGCAGTCAATGAAGCTGGAACCACAGAAAGAAAATATAACCTCAAAGTCCATGTTCCTCCAGTAATTAAAGATAAAGAACAAGTT ACAAATGTGTCGGTGTTGTTAAATCAGCTGACCAATCTCTTCTGTGAAGTGGAAGGCACTCCATCTCCCATCATTATGTGGTATAAAGAT AATGTCCAGGTGACTGAAAGCAGCACTATTCAGACTGTGAACAATGGGAAGATACTGAAGCTCTTCAGAGCCACTCCAGAGGATGCAGGA AGATATTCCTGCAAAGCAATTAATATTGCAGGCACTTCTCAGAAGTACTTTAACATTGATGTGCTAGTTCCACCCACCATAATAGGTACC AACTTCCCAAATGAAGTCTCAGTTGTCCTCAACCGTGACGTCGCCCTTGAATGCCAGGTCAAAGGCACTCCCTTTCCTGATATTCATTGG TTCAAAGATGGCAAGCCTTTATTTTTGGGCGATCCTAATGTTGAACTTCTAGACAGAGGACAAGTCTTACATTTAAAGAATGCACGGAGA AATGACAAGGGGCGCTACCAATGTACTGTGTCTAATGCAGCTGGCAAACAAGCCAAGGATATAAAACTGACTATCTATATTCCACCTAGT ATTAAAGGAGGAAATGTCACCACAGACATATCAGTATTGATCAACAGCCTTATTAAACTGGAATGTGAAACACGGGGACTTCCAATGCCT GCCATTACTTGGTATAAGGACGGGCAGCCAATCATGTCCAGCTCACAAGCACTTTATATTGATAAAGGACAATATCTTCATATTCCTCGA GCACAGGTCTCTGATTCAGCAACATATACGTGTCATGTAGCCAATGTTGCTGGAACTGCTGAAAAATCATTCCATGTGGATGTCTATGTT CCTCCAATGATTGAAGGCAACTTGGCCACGCCTTTGAATAAGCAAGTAGTTATTGCTCATTCTCTGACACTGGAGTGCAAAGCTGCTGGA AACCCTTCTCCCATTCTCACCTGGTTGAAAGATGGTGTACCTGTGAAAGCTAATGACAATATCCGCATAGAAGCTGGTGGGAAGAAACTC GAAATCATGAGTGCCCAAGAAATTGATCGAGGACAGTACATATGCGTGGCTACCAGTGTGGCAGGAGAAAAGGAAATCAAATATGAAGTT GATGTCTTGGTGCCACCAGCTATAGAAGGAGGAGATGAAACATCTTACTTCATTGTGATGGTTAATAACTTACTGGAGCTAGATTGTCAT GTGACAGGCTCTCCCCCACCAACTATCATGTGGCTGAAGGATGGCCAGTTAATTGATGAAAGGGATGGATTCAAGATTTTATTAAATGGA CGCAAACTGGTTATTGCTCAGGCTCAAGTGTCAAACACAGGCCTTTATCGGTGCATGGCAGCAAATACTGCTGGAGACCACAAGAAGGAA TTTGAAGTGACTGTTCATGTTCCTCCAACAATCAAGTCCTCAGGCCTTTCTGAGAGAGTTGTGGTAAAATACAAGCCTGTCGCCTTGCAG TGCATAGCCAATGGGATTCCAAATCCTTCCATTACATGGTTAAAAGATGACCAGCCTGTGAACACTGCCCAAGGAAACCTTAAAATACAG TCTTCTGGTCGAGTTCTACAAATTGCCAAAACCCTGTTGGAAGATGCTGGCAGATACACATGTGTGGCTACCAACGCAGCTGGAGAAACA CAACAGCACATTCAACTGCATGTTCATGAACCACCTAGTCTGGAAGATGCTGGAAAAATGCTGAATGAGACTGTGTTGGTGAGCAACCCT GTACAGCTGGAGTGTAAGGCAGCTGGAAATCCTGTGCCTGTTATTACATGGTACAAAGATAATCGTCTACTCTCAGGTTCCACCAGCATG ACTTTCTTGAACAGAGGACAGATCATTGATATTGAAAGTGCCCAGATCTCAGATGCTGGCATATATAAATGCGTGGCCATCAACTCAGCT GGAGCTACAGAGTTATTTTACAGTCTGCAAGTTCATGTGGCCCCATCAATTTCTGGCAGCAATAACATGGTGGCAGTGGTGGTTAATAAC CCGGTGAGGTTAGAATGTGAAGCCAGAGGTATTCCTGCCCCAAGTCTGACCTGGTTGAAAGATGGGAGTCCTGTTTCTAGTTTTTCTAAT GGATTACAGGTTCTCTCTGGTGGTCGAATCCTAGCATTGACCAGTGCACAAATCAGCGACACAGGAAGGTACACCTGCGTGGCAGTGAAT GCTGCTGGAGAAAAGCAAAGGGACATTGACCTCCGAGTATATGTTCCGCCAAATATTATGGGAGAAGAACAGAATGTCTCTGTCCTCATT AGCCAAGCTGTGGAATTACTATGTCAAAGTGATGCTATTCCCCCACCTACTCTTACTTGGTTAAAAGACGGCCACCCCTTGCTGAAGAAA CCAGGCCTCAGTATATCTGAAAATAGAAGTGTGTTAAAGATTGAAGATGCTCAGGTTCAAGACACTGGTCGTTACACTTGTGAAGCAACA AATGTTGCTGGAAAAACTGAAAAAAACTACAATGTCAACATTTGGGTCCCCCCAAATATTGGTGGTTCTGATGAACTTACTCAACTTACA GTCATTGAAGGGAATCTCATTAGTCTGTTGTGTGAATCAAGTGGTATTCCACCCCCAAATCTCATCTGGAAGAAGAAAGGCTCTCCAGTG CTGACTGATTCCATGGGGCGAGTTAGAATTTTATCTGGGGGCAGGCAATTACAAATTTCAATTGCTGAAAAGTCTGATGCAGCACTCTAT TCATGTGTGGCGTCGAATGTTGCTGGGACTGCAAAGAAAGAATACAATCTGCAAGTTTACATTAGACCAACCATAACCAACAGTGGCAGC CACCCTACTGAAATTATTGTGACCCGAGGGAAGAGTATCTCCTTGGAGTGTGAGGTGCAGGGTATTCCACCACCAACAGTGACCTGGATG AAAGATGGCCACCCCTTGATCAAGGCAAAGGGAGTAGAAATACTGGATGAAGGTCACATCCTTCAGCTGAAGAACATTCATGTATCTGAC ACAGGCCGTTATGTGTGTGTTGCTGTGAATGTAGCAGGAATGACTGACAAAAAATATGACTTAAGTGTCCATGCTCCTCCAAGCATCATA GGAAACCACAGGTCACCTGAAAATATTAGTGTGGTAGAAAAGAACTCAGTATCTTTGACTTGTGAAGCTTCTGGAATTCCCCTGCCTTCC ATAACCTGGTTCAAAGATGGGTGGCCTGTCAGCCTTAGCAATTCTGTGAGGATTCTTTCAGGAGGCAGGATGCTACGGCTGATGCAGACC ACAATGGAAGATGCTGGCCAATATACTTGCGTTGTAAGGAATGCAGCTGGTGAAGAAAGAAAAATCTTTGGGCTTTCAGTATTAGTACCA CCTCATATTGTGGGTGAAAATACATTGGAAGATGTGAAGGTAAAAGAGAAACAGAGTGTTACGCTGACTTGTGAAGTGACAGGGAATCCA GTGCCAGAAATTACATGGCACAAAGATGGGCAGCCCCTCCAAGAAGATGAAGCCCATCACATTATATCTGGTGGCCGTTTTCTTCAAATT ACCAATGTCCAGGTGCCACACACTGGAAGATATACATGTTTGGCTTCCAGTCCAGCTGGCCACAAGAGCAGGAGCTTCAGTCTTAATGTA TTTGTATCTCCTACAATTGCTGGTGTAGGTAGTGATGGCAACCCTGAAGATGTCACTGTCATCCTTAACAGCCCTACATCTTTGGTCTGT GAAGCTTATTCATATCCTCCAGCTACCATCACCTGGTTTAAGGATGGCACTCCTTTAGAATCTAACCGAAATATTCGTATTCTTCCAGGA GGCAGAACTCTGCAGATCCTCAATGCACAGGAGGACAATGCTGGAAGATACTCTTGTGTAGCCACGAATGAGGCTGGAGAAATGATAAAG CACTATGAAGTGAAGGTGTACATTCCACCCATAATCAATAAAGGGGACCTTTGGGGGCCAGGTCTTTCCCCTAAAGAAGTGAAGATCAAA GTAAACAACACTCTGACCTTGGAATGTGAAGCGTATGCAATTCCTTCTGCCTCCCTCAGCTGGTACAAGGATGGACAGCCCCTTAAATCC GATGATCATGTTAATATTGCTGCGAATGGACACACACTTCAAATAAAGGAGGCTCAAATATCAGACACCGGACGATATACTTGTGTAGCA TCTAACATTGCAGGTGAAGATGAGTTGGATTTTGATGTGAATATTCAAGTTCCTCCAAGTTTTCAGAAACTCTGGGAAATAGGAAACATG CTAGATACTGGCAGGAATGGTGAAGCCAAAGATGTGATCATCAACAATCCCATTTCTCTTTACTGTGAGACAAATGCTGCTCCCCCTCCT ACACTGACATGGTACAAAGATGGCCACCCTCTGACCTCAAGTGATAAAGTATTGATTTTGCCAGGAGGGCGAGTGTTGCAGATTCCTCGG GCTAAAGTAGAAGATGCTGGGAGATACACATGTGTGGCTGTGAATGAGGCTGGAGAAGATTCCCTTCAATATGATGTCCGTGTACTCGTG CCGCCAATTATCAAGGGAGCAAATAGTGATCTCCCTGAAGAGGTCACCGTGCTGGTGAACAAGAGTGCACTGATAGAGTGTTTATCCAGT GGCAGCCCAGCACCAAGGAATTCCTGGCAGAAAGATGGACAGCCCTTGCTAGAAGATGACCATCATAAATTTCTATCTAATGGACGAATT CTGCAGATTCTGAATACTCAAATAACAGATATCGGCAGGTATGTGTGTGTTGCTGAGAACACAGCTGGGAGTGCCAAAAAATATTTTAAC CTCAATGTTCATGTTCCTCCAAGTGTCATTGGTCCTAAATCTGAAAATCTTACCGTCGTGGTGAACAATTTCATCTCTTTGACCTGTGAG GTCTCTGGTTTTCCACCTCCTGACCTCAGCTGGCTCAAGAATGAACAGCCCATCAAACTGAACACAAATACTCTCATTGTGCCTGGTGGT CGAACTCTACAGATTATTCGGGCCAAGGTATCAGATGGTGGTGAATACACTTGTATAGCTATCAATCAAGCTGGCGAAAGCAAGAAAAAG TTTTCCCTGACTGTTTATGTGCCCCCAAGCATTAAAGACCATGACAGTGAATCTCTTTCTGTAGTTAATGTAAGAGAGGGAACTTCTGTG TCTTTGGAGTGTGAGTCGAACGCTGTGCCACCTCCAGTCATCACTTGGTATAAGAATGGGCGGATGATAACAGAGTCTACTCATGTGGAG ATTTTAGCTGATGGACAAATGCTACACATTAAGAAAGCTGAGGTATCTGACACAGGCCAGTATGTATGTAGAGCTATAAATGTAGCAGGA CGGGATGATAAAAATTTCCACCTCAATGTATATGTGCCACCCAGTATTGAAGGACCTGAAAGAGAAGTGATTGTGGAGACGATCAGCAAT CCTGTGACATTAACATGTGATGCCACTGGGATCCCACCTCCCACGATAGCATGGTTAAAGAACCACAAGCGCATAGAAAATTCTGACTCA CTGGAAGTTCGTATTTTGTCTGGAGGTAGCAAACTCCAGATTGCCCGGTCTCAGCATTCAGATAGTGGAAACTATACATGTATTGCTTCA AATATGGAGGGAAAAGCCCAGAAATATTACTTTCTTTCAATTCAAGTTCCTCCAAGTGTTGCTGGTGCTGAAATTCCAAGTGATGTCAGT GTCCTTCTAGGAGAAAATGTTGAGCTGGTCTGCAATGCAAATGGCATTCCTACTCCACTTATTCAATGGCTTAAAGATGGAAAGCCCATA GCTAGTGGTGAAACAGAAAGAATCCGAGTGAGTGCAAATGGCAGCACATTAAACATTTATGGAGCTCTTACATCTGACACGGGGAAATAC ACATGTGTTGCTACTAATCCCGCTGGAGAAGAAGACCGAATTTTTAACTTGAATGTCTATGTTACACCTACAATTAGGGGTAATAAAGAT GAAGCAGAGAAACTAATGACTTTAGTGGATACTTCAATAAATATTGAATGCAGAGCCACAGGGACGCCTCCACCACAGATAAACTGGCTG AAGAATGGACTTCCTCTGCCTCTCTCCTCCCATATCCGGTTACTGGCAGCAGGACAAGTTATCAGGATTGTGAGAGCTCAGGTGTCTGAT GTCGCTGTGTATACTTGTGTGGCCTCCAACAGAGCTGGGGTGGATAATAAGCATTACAATCTTCAAGTGTTTGCACCACCAAATATGGAC AATTCAATGGGGACAGAGGAAATCACAGTTCTCAAAGGTAGTTCCACCTCTATGGCATGCATTACTGATGGAACCCCAGCTCCCAGTATG GCCTGGCTTAGAGATGGCCAGCCTCTGGGGCTTGATGCCCATCTGACAGTCAGCACCCATGGAATGGTCCTGCAGCTCCTCAAAGCAGAG ACTGAAGATTCGGGAAAGTACACCTGCATTGCCTCAAATGAAGCTGGAGAAGTCAGCAAGCACTTTATCCTCAAGGTCCTAGAACCACCT CACATTAATGGATCTGAAGAACATGAAGAGATATCAGTAATTGTTAATAACCCACTTGAACTTACCTGCATTGCTTCTGGAATCCCAGCC CCTAAAATGACCTGGATGAAAGATGGCCGGCCCCTTCCACAGACGGATCAAGTGCAAACTCTAGGAGGAGGAGAGGTTCTTCGAATTTCT ACTGCTCAGGTGGAGGATACAGGAAGATATACATGTCTGGCATCCAGTCCTGCAGGAGATGATGATAAGGAATATCTAGTGAGAGTGCAT GTACCTCCTAATATTGCTGGAACTGATGAGCCCCGGGATATCACTGTGTTACGGAACAGACAAGTGACATTGGAATGCAAGTCAGATGCA GTGCCCCCACCTGTAATTACTTGGCTCAGAAATGGAGAACGGTTACAGGCAACACCTCGAGTGCGAATCCTATCTGGAGGGAGATACTTG CAAATCAACAATGCTGACCTAGGTGATACAGCCAATTATACCTGTGTTGCCAGCAACATTGCAGGAAAGACTACAAGAGAATTTATTCTC ACTGTAAATGTTCCTCCAAACATAAAGGGGGGCCCCCAGAGCCTTGTAATTCTTTTAAATAAGTCAACTGTATTGGAATGCATCGCTGAA GGTGTGCCAACTCCAAGGATAACATGGAGAAAGGATGGAGCTGTTCTAGCTGGGAATCATGCAAGATATTCCATCTTGGAAAATGGATTC CTTCATATTCAATCAGCACATGTCACTGACACTGGACGGTATTTGTGTATGGCCACCAATGCTGCTGGAACAGATCGCAGGCGAATAGAT TTACAGGTCCATGTTCCTCCATCTATTGCTCCGGGTCCTACCAACATGACTGTAATAGTAAATGTTCAAACTACTCTGGCTTGTGAGGCT ACTGGGATACCAAAACCATCAATCAATTGGAGAAAAAATGGGCATCTTCTTAATGTGGATCAAAATCAGAACTCATACAGGCTCCTTTCT TCAGGTTCACTAGTAATTATTTCCCCTTCTGTGGATGACACTGCAACCTATGAATGTACTGTGACAAACGGTGCTGGAGATGATAAAAGA ACTGTGGATCTCACTGTCCAAGTTCCACCTTCCATAGCTGATGAGCCTACAGATTTCCTAGTAACCAAACATGCCCCAGCAGTAATTACC TGCACTGCTTCGGGAGTTCCATTTCCCTCAATTCACTGGACCAAAAATGGTATAAGACTGCTTCCCAGGGGAGATGGCTATAGAATTCTG TCCTCAGGAGCAATTGAAATACTTGCCACCCAATTAAACCATGCTGGAAGATACACTTGTGTCGCTAGGAATGCGGCTGGCTCTGCACAT CGACACGTGACCCTTCATGTTCATGAGCCTCCAGTCATTCAGCCCCAACCAAGTGAACTACACGTCATTCTGAACAATCCTATTTTATTA CCATGTGAAGCAACAGGGACACCCAGTCCTTTCATTACTTGGCAAAAAGAAGGCATCAATGTTAACACTTCAGGCAGAAACCATGCAGTT CTTCCTAGTGGCGGCTTACAGATCTCCAGAGCTGTCCGAGAGGATGCTGGCACTTACATGTGTGTGGCCCAGAACCCGGCTGGTACAGCC TTGGGCAAAATCAAGTTAAATGTCCAAGTTCCTCCAGTCATTAGCCCTCATCTAAAGGAATATGTTATTGCTGTGGACAAGCCCATCACG TTATCCTGTGAAGCAGATGGCCTCCCTCCGCCTGACATTACATGGCATAAAGATGGGCGTGCAATTGTGGAATCTATCCGCCAGCGCGTC CTCAGCTCTGGCTCTCTGCAAATAGCATTTGTCCAGCCTGGTGATGCTGGCCATTACACGTGCATGGCAGCCAATGTAGCAGGATCAAGC AGCACAAGCACCAAGCTCACCGTCCATGTACCACCCAGGATCAGAAGTACAGAAGGACACTACACGGTCAATGAGAATTCACAAGCCATT CTTCCATGCGTAGCTGATGGAATCCCCACACCAGCAATTAACTGGAAAAAAGACAATGTTCTTTTAGCTAACTTGTTAGGAAAATACACT GCTGAACCATATGGAGAACTCATTTTAGAAAATGTTGTGCTGGAGGATTCTGGCTTCTATACCTGTGTTGCTAACAATGCTGCAGGTGAA GATACACACACTGTCAGCCTGACTGTGCATGTTCTCCCCACTTTTACTGAACTTCCTGGAGACGTGTCATTAAATAAAGGAGAACAGCTA CGATTAAGCTGTAAAGCTACTGGTATTCCATTGCCCAAATTAACATGGACCTTCAATAACAATATTATTCCAGCCCACTTTGACAGTGTG AATGGACACAGTGAACTTGTTATTGAAAGAGTGTCAAAAGAGGATTCAGGTACTTATGTGTGCACCGCAGAGAACAGCGTTGGCTTTGTG AAGGCAATTGGATTTGTTTATGTGAAAGAACCTCCAGTCTTCAAAGGTGATTATCCTTCTAACTGGATTGAACCACTTGGTGGGAATGCA ATCCTGAATTGTGAGGTGAAAGGAGACCCCACCCCAACCATCCAGTGGAACAGAAAGGGAGTGGATATTGAAATTAGCCACAGAATCCGG CAACTGGGCAATGGCTCCCTGGCCATCTATGGCACTGTTAATGAAGATGCCGGTGACTATACATGTGTAGCTACCAATGAAGCTGGGGTG GTGGAGCGCAGCATGAGTCTGACTCTGCAAAGTCCTCCTATTATCACTCTTGAGCCAGTGGAAACTGTTATTAATGCTGGTGGCAAAATC ATATTGAATTGTCAGGCAACTGGAGAGCCTCAACCAACCATTACATGGTCCCGTCAAGGGCACTCTATTTCCTGGGATGACCGGGTTAAC GTGTTGTCCAACAACTCATTATATATTGCTGATGCTCAGAAAGAAGATACCTCTGAATTTGAATGTGTTGCTCGAAACTTAATGGGTTCT GTCCTTGTCAGAGTGCCAGTCATAGTCCAGGTTCATGGTGGATTTTCCCAGTGGTCTGCATGGAGAGCCTGCAGTGTCACCTGTGGAAAA GGCATCCAAAAGAGGAGTCGTCTGTGCAACCAGCCCCTTCCAGCCAATGGTGGGAAGCCCTGCCAAGGTTCAGATTTGGAAATGCGAAAC TGTCAAAATAAGCCTTGTCCAGTGGATGGTAGCTGGTCGGAATGGAGTCTTTGGGAAGAATGCACAAGGAGCTGTGGACGCGGCAACCAA ACCAGGACCAGGACTTGCAATAATCCATCAGTTCAGCATGGTGGGCGGCCATGTGAAGGGAATGCTGTGGAAATAATTATGTGCAACATT AGGCCTTGCCCAGTTCATGGAGCATGGAGCGCTTGGCAGCCTTGGGGAACATGCAGCGAAAGTTGTGGGAAAGGTACTCAGACAAGAGCA AGACTTTGTAATAACCCACCACCAGCGTTTGGTGGGTCCTACTGTGATGGAGCAGAAACACAGATGCAAGTTTGCAATGAAAGAAATTGT CCAATTCATGGCAAGTGGGCGACTTGGGCCAGTTGGAGTGCCTGTTCTGTGTCATGTGGAGGAGGTGCCAGACAGAGAACAAGGGGCTGC TCCGACCCTGTGCCCCAGTATGGAGGAAGGAAATGCGAAGGGAGTGATGTCCAGAGTGATTTTTGCAACAGTGACCCTTGCCCAACCCAT GGTAACTGGAGTCCTTGGAGTGGCTGGGGAACATGCAGCCGGACGTGTAACGGAGGGCAGATGCGGCGGTACCGCACATGTGATAACCCT CCTCCCTCCAATGGGGGAAGAGCTTGTGGGGGACCAGACTCCCAGATCCAGAGGTGCAACACTGACATGTGTCCTGTGGATGGAAGTTGG GGAAGCTGGCATAGTTGGAGCCAGTGCTCTGCCTCCTGTGGAGGAGGTGAAAAGACTCGGAAGCGGCTGTGCGACCATCCTGTGCCAGTT AAAGGTGGCCGTCCCTGTCCCGGAGACACTACTCAGGTGACCAGGTGCAATGTACAAGCATGTCCAGGTGGGCCCCAGCGAGCCAGAGGA AGTGTTATTGGAAATATTAATGATGTTGAATTTGGAATTGCTTTCCTTAATGCCACAATAACTGATAGCCCTAACTCTGATACTAGAATA ATACGTGCCAAAATTACCAATGTACCTCGTAGTCTTGGTTCAGCAATGAGAAAGATAGTTTCTATTCTAAATCCCATTTATTGGACAACA GCAAAGGAAATAGGAGAAGCAGTCAATGGCTTTACCCTCACCAATGCAGTCTTCAAAAGAGAAACTCAAGTGGAATTTGCAACTGGAGAA ATCTTGCAGATGAGTCATATTGCCCGGGGCTTGGATTCCGATGGTTCTTTGCTGCTAGATATCGTTGTGAGTGGCTATGTCCTACAGCTT CAGTCACCTGCTGAAGTCACTGTAAAGGATTACACAGAGGACTACATTCAAACAGGTCCTGGGCAGCTGTACGCCTACTCAACCCGGCTG TTCACCATTGATGGCATCAGCATCCCATACACATGGAACCACACCGTTTTCTATGATCAGGCACAGGGAAGAATGCCTTTCTTGGTTGAA ACACTTCATGCATCCTCTGTGGAATCTGACTATAACCAGATAGAAGAGACACTGGGTTTTAAAATTCATGCTTCAATATCCAAAGGAGAT CGCAGTAATCAGTGCCCCTCCGGGTTTACCTTAGACTCAGTTGGACCTTTTTGTGCTGATGAGGATGAATGTGCAGCAGGGAATCCCTGC TCCCATAGCTGCCACAATGCCATGGGGACTTACTACTGCTCCTGCCCTAAAGGCCTCACCATAGCTGCAGATGGAAGAACTTGTCAAGAT ATTGATGAGTGTGCTTTGGGTAGGCATACCTGCCACGCTGGTCAGGACTGTGACAATACGATTGGATCTTATCGCTGTGTGGTCCGTTGT GGAAGTGGCTTTCGAAGAACCTCTGATGGGCTGAGTTGTCAAGATATTAATGAATGTCAAGAATCCAGCCCCTGTCACCAGCGCTGTTTC AATGCCATAGGAAGTTTCCATTGTGGATGTGAACCTGGGTATCAGCTCAAAGGCAGAAAATGCATGGATGTGAACGAGTGTAGACAAAAT GTATGCAGACCAGATCAGCACTGTAAGAACACCCGTGGTGGCTATAAGTGCATTGATCTTTGTCCAAATGGAATGACCAAGGCAGAAAAT GGAACCTGTATTGATATTGATGAATGTAAAGATGGGACCCATCAGTGCAGATATAACCAGATATGTGAGAATACAAGAGGCAGCTATCGT TGTGTATGCCCAAGAGGTTATCGGTCTCAAGGAGTTGGAAGACCCTGCATGGACATTAATGAATGTGAACAAGTGCCTAAACCTTGTGCA CATCAGTGCTCCAACACCCCCGGCAGCTTCAAGTGTATCTGTCCACCAGGACAACATTTATTAGGGGACGGGAAATCTTGCGCTGGATTG GAGAGGCTGCCAAATTATGGCACTCAATACAGTAGCTATAACCTTGCACGGTTCTCCCCTGTGAGAAACAACTATCAACCTCAACAGCAT TACAGACAGTACTCACATCTCTACAGCTCCTACTCAGAGTATAGAAACAGCAGAACATCTCTCTCCAGGACTAGAAGGACTATTAGGAAA ACTTGCCCTGAAGGCTCTGAGGCAAGCCATGACACATGTGTAGATATTGATGAATGTGAAAATACAGATGCCTGCCAGCATGAGTGTAAG AATACCTTTGGAAGTTATCAGTGCATCTGCCCACCTGGCTATCAACTCACACACAATGGAAAGACATGCCAAGATATCGATGAATGTCTG GAGCAGAATGTGCACTGTGGACCCAATCGCATGTGCTTCAACATGAGAGGAAGCTACCAGTGCATCGATACACCCTGTCCACCCAACTAC CAACGGGATCCTGTTTCAGGGTTCTGCCTCAAGAACTGTCCACCCAATGATTTGGAATGTGCCTTGAGCCCATATGCCTTGGAATACAAA CTCGTCTCCCTCCCATTTGGAATAGCCACCAATCAAGATTTAATCCGGCTGGTTGCATACACACAGGATGGAGTGATGCATCCCAGGACA ACTTTCCTCATGGTAGATGAGGAACAGACTGTTCCTTTTGCCTTGAGGGATGAAAACCTGAAAGGAGTGGTGTATACAACACGACCACTA CGAGAAGCAGAGACCTACCGCATGAGGGTCCGAGCCTCATCCTACAGTGCCAATGGGACCATTGAATATCAGACCACATTCATAGTTTAT ATAGCTGTGTCCGCCTATCCATACTAAGGAACTCTCCAAAGCCTATTCCACATATTTAAACCGCATTAATCATGGCAATCAAGCCCCCTT CCAGATTACTGTCTCTTGAACAGTTGCAATCTTGGCAGCTTGAAAATGGTGCTACACTCTGTTTTGTGTGCCTTCCTTGGTACTTCTGAG GTATTTTCATGATCCCACCATGGTCATATCTTGAAGTATGGTCTAGAAAAGTCCCTTATTATTTTATTTATTACACTGGAGCAGTTACTT CCCAAAGATTATTCTGAACATCTAACAGGACATATCAGTGATGGTTTACAGTAGTGTAGTACCTAAGATCATTTTCCTGAAAGCCAAACC AAACAACGAAAAACAAGAACAACTAATTCAGAATCAAATAGAGTTTTTGAGCATTTGACTATTTTTAGAATCATAAAATTAGTTACTAAG TATTTTGATCAAAGCTTATAAAATAACTTACGGAGATTTTTGTAAGTATTGATACATTATAATAGGACTTGCCTATTTTCATTTTTAAGA AGAAAAACACCACTCATTTTATAAAATATAGTACAGCTACTATAAGGCTTGTTTGATCCCAAATGGTGCTTATCTTGATTGAACATTCAG AACAAGGATATTATTTTCAGTGATTTTGTGAGATCAGCTGAACCACTTATGATAATAATAATAAAAAAGACTGCTTTGCCCTCACGTCAG TTGTACATGGCATGGAACTTTAAAAATTTTAATATAAACTTTCATCCAGTTAGCTTCATAACTTTTACGTTCCAGAATTTTGTTTATTTT CCTGTCAATGAAAGCAATTTTTAAAGATACCAGTGGGACAGATTTGGTTTTTTAAAAATCTCATGTGTTCAAATTAACATAAATATTACA CGTCAATACACTGTACATGGTGGTAATAGACTCTAAGCAATTGCCAAGATGTATTCTATTTTTATGAAGTGTATATATATTACCTTAGTG TGCATTTTCTATATAATATCTTGATGGACTCTTTTATAAAATTATTTTATAAAAAACAATGTTACACTAAAATCAGCCTAAATAAATTTT >92059_92059_1_TMEM2-HMCN1_TMEM2_chr9_74309425_ENST00000396272_HMCN1_chr1_185878469_ENST00000271588_length(amino acids)=5653AA_BP=225 MTITRDEYPSNPMVLRGINQKAAFPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCYPSNTSFQVTFGYLQRQNGSLSK IEEYEPVHSLEELQRKQSERKFYFDSSTGLLFLYLKAKSHRHGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYRKPSVVKRMPAM LTGLCQGCGTRQVVFTSDPHKSYLPVQFQSPDKAETQRGDPSVISVLKWVEEAVQASKVHLLSTDHLEQAVNTWRIPFDPSLKEVTVSLS GPSPMIEIRNPLGKLIKKGFGLHELLNIHNSAKVVNVKEPEAGMWTVKTSSSGRHSVRITGLSTIDFRAGFSRKPTLDFKKTVSRPVQGI PTYVLLNTSGISTPARIDLLELLSISGSSLKTIPVKYYPHRKPYGIWNISDFVPPNEAFFLKVTGYDKDDYLFQRVSSVSFSSIVPDAPK VTMPEKTPGYYLQPGQIPCSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPV IQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPP KVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAP KLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSP PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTV TVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKT TSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKR KVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVA TNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCV ATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYD NGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRAT PEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHL KNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQY LHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEA GGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFK ILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQG NLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLS GSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPV SSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGH PLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKK KGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPP TVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASG IPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCE VTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSP TSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPK EVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLW EIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYD VRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSA KKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAG ESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRA INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNY TCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTS DTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVR AQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQ LLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGE VLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILS GGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSI LENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNS YRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGD GYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSG RNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVES IRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANL LGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA HFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEI SHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISW DDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSD LEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHGAWSAWQPWGTCSESCGKG TQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSD PCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCD HPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDSPNSDTRIIRAKITNVPRSLGSAMRKIVSILNP IYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILQMSHIARGLDSDGSLLLDIVVSGYVLQLQSPAEVTVKDYTEDYIQTGPGQLYA YSTRLFTIDGISIPYTWNHTVFYDQAQGRMPFLVETLHASSVESDYNQIEETLGFKIHASISKGDRSNQCPSGFTLDSVGPFCADEDECA AGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPC HQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENT RGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNY QPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQD IDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLPFGIATNQDLIRLVAYTQDGV -------------------------------------------------------------- >92059_92059_2_TMEM2-HMCN1_TMEM2_chr9_74309425_ENST00000396272_HMCN1_chr1_185878469_ENST00000367492_length(transcript)=17851nt_BP=840nt CACTTAGTCTGGCACAGATCACAGAATCTCCCTTTTCAAAGTTGAGACACTTGACTTTGTGCTGAAAATGTCTTTTTAGCTGTTTAAATT TTCATTCTCTTCCCTTTACTTCTTGATTATTTTTTCAAGGTCTATGTACAGACATGGAGCACTCAGAATCTTTCTATGACCATTACACGA GATGAGTATCCGTCCAACCCTATGGTGCTCCGAGGTATTAATCAGAAGGCTGCCTTTCCACAGTACCAGCCTGTCGTCATGCTGGAGAAG GGTTATACCATCCACTGGAATGGGCCGGCACCACGGACTACATTTCTATACCTCGTCAACTTCAACAAGAATGACTGGATTCGAGTTGGC CTTTGCTATCCATCAAACACAAGTTTTCAAGTTACCTTTGGCTATTTGCAGCGGCAGAATGGCTCATTATCCAAAATCGAAGAATATGAG CCTGTGCATTCACTGGAAGAACTGCAAAGAAAGCAATCCGAGAGGAAATTCTATTTTGACTCCAGCACGGGGTTACTGTTTTTGTATCTC AAAGCCAAAAGCCACAGGCATGGCCACAGTTACTGTTCATCTCAGGGATGTGAAAGAGTCAAGATCCAAGCAGCCACAGACTCAAAGGAC ATCAGTAACTGCATGGCCAAAGCATACCCACAGTACTACAGAAAGCCGTCAGTGGTCAAGCGGATGCCGGCCATGCTCACTGGACTCTGT CAAGGCTGTGGCACTCGGCAGGTGGTGTTTACTAGTGATCCTCATAAAAGTTACCTCCCTGTGCAATTCCAGTCACCTGATAAAGCAGAA ACCCAGCGTGGAGACCCGTCTGTTATTTCTGTATTAAAATGGGTAGAAGAAGCAGTACAGGCCTCCAAAGTTCACCTTTTATCCACAGAT CATTTGGAACAGGCTGTAAATACTTGGAGAATTCCTTTTGATCCCAGCCTGAAAGAGGTCACTGTGTCTTTGAGTGGGCCTTCTCCAATG ATTGAAATTCGCAATCCTTTAGGGAAGCTGATAAAAAAGGGATTTGGCCTGCATGAGCTATTAAATATCCATAACTCTGCCAAAGTAGTG AATGTGAAAGAGCCAGAGGCTGGAATGTGGACAGTGAAGACCTCAAGCAGTGGAAGGCACTCTGTTCGCATTACTGGCCTCAGTACTATT GATTTCCGAGCTGGCTTTTCTCGAAAGCCCACCCTGGACTTCAAAAAAACAGTCAGCAGACCAGTGCAAGGAATACCTACCTATGTACTG CTCAATACTTCTGGAATTTCCACTCCAGCTAGAATAGATCTTCTTGAACTTTTGAGTATCTCAGGAAGTTCTCTTAAGACTATTCCTGTT AAATATTACCCACATCGAAAACCTTATGGCATATGGAATATTTCTGACTTTGTACCACCAAATGAAGCTTTCTTTCTCAAAGTAACAGGC TATGATAAAGATGATTACCTCTTCCAGAGAGTATCAAGTGTTTCCTTTTCTAGTATTGTCCCAGATGCTCCCAAAGTTACGATGCCTGAG AAAACCCCAGGATACTATCTGCAGCCGGGCCAAATTCCCTGCTCTGTTGACAGTCTTTTGCCCTTTACCTTGAGCTTTGTCAGAAATGGA GTTACACTTGGAGTAGACCAGTATTTGAAAGAATCTGCCAGTGTGAACTTAGATATTGCAAAGGTCACTTTGTCTGACGAAGGTTTCTAT GAATGCATTGCTGTCAGCAGTGCAGGTACTGGACGGGCACAGACATTTTTTGACGTATCAGAGCCCCCTCCGGTCATCCAAGTGCCTAAC AATGTTACAGTCACTCCTGGAGAGAGAGCAGTTTTAACATGTCTCATCATCAGTGCGGTGGATTACAATCTAACCTGGCAGAGGAATGAC AGAGATGTCAGACTGGCAGAGCCAGCGAGAATTAGGACCTTGGCTAATCTGTCATTGGAGCTAAAGAGTGTGAAATTCAACGATGCTGGA GAGTATCATTGTATGGTTTCTAGTGAAGGTGGATCATCAGCCGCTTCAGTTTTCCTCACAGTGCAAGAACCACCCAAAGTCACTGTGATG CCCAAGAATCAGTCTTTCACAGGAGGGTCTGAGGTCTCCATCATGTGTTCTGCAACAGGTTATCCCAAACCAAAGATTGCCTGGACCGTT AACGATATGTTTATCGTGGGTTCACACAGGTATAGGATGACCTCAGATGGTACCTTATTTATCAAAAATGCAGCTCCCAAAGATGCAGGG ATCTATGGTTGCCTAGCAAGTAATTCAGCTGGAACAGATAAACAGAATTCTACTCTCAGATACATTGAAGCCCCTAAGTTGATGGTAGTT CAGAGTGAGCTCTTGGTTGCCCTTGGGGATATAACCGTTATGGAATGCAAAACCTCTGGTATTCCTCCACCTCAAGTTAAATGGTTCAAA GGAGATCTTGAGTTGAGGCCCTCAACATTCCTCATTATTGACCCTCTCTTGGGACTTTTGAAGATTCAAGAAACACAAGATCTGGATGCT GGCGATTATACCTGTGTAGCCATCAATGAGGCTGGAAGAGCAACTGGCAAGATAACTCTGGATGTTGGCTCACCTCCAGTTTTCATACAA GAACCTGCTGATGTGTCTATGGAAATTGGCTCAAATGTGACATTACCTTGTTATGTTCAGGGTTATCCAGAACCAACAATCAAATGGCGA AGATTAGACAACATGCCAATTTTCTCAAGACCTTTTTCAGTTAGTTCCATCAGCCAACTAAGAACAGGAGCTCTCTTTATTTTAAACTTA TGGGCAAGTGATAAAGGAACCTATATTTGTGAAGCTGAAAACCAGTTTGGAAAGATCCAGTCAGAGACAACAGTAACAGTGACCGGACTT GTTGCTCCACTTATTGGAATCAGCCCTTCAGTGGCCAATGTTATTGAAGGACAGCAGCTTACTTTGCCCTGTACTCTGTTAGCTGGAAAT CCCATTCCAGAACGTCGGTGGATTAAGAATTCAGCTATGTTGCTCCAAAATCCTTACATCACTGTGCGCAGTGATGGGAGCCTCCATATT GAAAGAGTTCAGCTTCAGGATGGTGGTGAATATACTTGTGTGGCCAGTAACGTTGCTGGGACCAATAACAAAACTACCTCTGTGGTTGTG CATGTTCTGCCAACCATTCAGCATGGGCAGCAGATACTCAGTACAATTGAAGGCATTCCAGTAACTTTACCATGCAAAGCAAGTGGAAAT CCCAAACCGTCTGTCATCTGGTCCAAGAAAGGAGAGCTGATTTCAACCAGCAGTGCTAAGTTTTCAGCAGGAGCTGATGGTAGTCTGTAT GTGGTATCACCTGGAGGAGAGGAGAGTGGGGAGTATGTCTGCACTGCCACCAATACAGCCGGCTACGCCAAAAGGAAAGTGCAGCTAACA GTCTATGTAAGGCCCAGAGTGTTTGGAGATCAACGAGGACTGTCCCAGGATAAGCCTGTTGAGATCTCCGTCCTTGCAGGGGAAGAGGTA ACACTTCCATGTGAAGTGAAGAGCTTACCTCCACCCATAATTACTTGGGCCAAAGAAACCCAGCTCATCTCACCGTTCTCTCCAAGACAC ACATTCCTCCCTTCTGGTTCAATGAAGATCACTGAAACCCGCACTTCAGATAGTGGGATGTATCTTTGTGTTGCCACAAATATTGCTGGG AATGTGACTCAGGCTGTCAAATTAAATGTCCATGTTCCTCCAAAGATACAGCGTGGACCTAAACATCTCAAAGTCCAAGTTGGTCAAAGA GTGGATATTCCATGTAATGCTCAAGGGACTCCTCTTCCTGTAATCACCTGGTCCAAAGGTGGAAGCACTATGCTGGTTGATGGAGAGCAC CATGTTAGCAATCCAGACGGAACTTTAAGCATCGACCAAGCCACGCCCTCAGATGCTGGCATATATACATGTGTTGCTACTAACATAGCA GGCACTGATGAAACAGAGATAACGCTACATGTCCAAGAACCACCCACAGTGGAAGATCTAGAACCTCCATATAACACTACTTTCCAAGAA AGAGTGGCCAATCAACGCATTGAATTTCCATGTCCTGCAAAAGGTACCCCTAAACCAACCATCAAATGGTTACACAATGGTAGAGAGTTG ACAGGCAGAGAGCCTGGCATTTCTATCTTGGAAGATGGCACATTGCTGGTTATTGCTTCTGTTACACCCTATGACAATGGGGAGTACATC TGTGTGGCAGTCAATGAAGCTGGAACCACAGAAAGAAAATATAACCTCAAAGTCCATGTTCCTCCAGTAATTAAAGATAAAGAACAAGTT ACAAATGTGTCGGTGTTGTTAAATCAGCTGACCAATCTCTTCTGTGAAGTGGAAGGCACTCCATCTCCCATCATTATGTGGTATAAAGAT AATGTCCAGGTGACTGAAAGCAGCACTATTCAGACTGTGAACAATGGGAAGATACTGAAGCTCTTCAGAGCCACTCCAGAGGATGCAGGA AGATATTCCTGCAAAGCAATTAATATTGCAGGCACTTCTCAGAAGTACTTTAACATTGATGTGCTAGTTCCACCCACCATAATAGGTACC AACTTCCCAAATGAAGTCTCAGTTGTCCTCAACCGTGACGTCGCCCTTGAATGCCAGGTCAAAGGCACTCCCTTTCCTGATATTCATTGG TTCAAAGATGGCAAGCCTTTATTTTTGGGCGATCCTAATGTTGAACTTCTAGACAGAGGACAAGTCTTACATTTAAAGAATGCACGGAGA AATGACAAGGGGCGCTACCAATGTACTGTGTCTAATGCAGCTGGCAAACAAGCCAAGGATATAAAACTGACTATCTATATTCCACCTAGT ATTAAAGGAGGAAATGTCACCACAGACATATCAGTATTGATCAACAGCCTTATTAAACTGGAATGTGAAACACGGGGACTTCCAATGCCT GCCATTACTTGGTATAAGGACGGGCAGCCAATCATGTCCAGCTCACAAGCACTTTATATTGATAAAGGACAATATCTTCATATTCCTCGA GCACAGGTCTCTGATTCAGCAACATATACGTGTCATGTAGCCAATGTTGCTGGAACTGCTGAAAAATCATTCCATGTGGATGTCTATGTT CCTCCAATGATTGAAGGCAACTTGGCCACGCCTTTGAATAAGCAAGTAGTTATTGCTCATTCTCTGACACTGGAGTGCAAAGCTGCTGGA AACCCTTCTCCCATTCTCACCTGGTTGAAAGATGGTGTACCTGTGAAAGCTAATGACAATATCCGCATAGAAGCTGGTGGGAAGAAACTC GAAATCATGAGTGCCCAAGAAATTGATCGAGGACAGTACATATGCGTGGCTACCAGTGTGGCAGGAGAAAAGGAAATCAAATATGAAGTT GATGTCTTGGTGCCACCAGCTATAGAAGGAGGAGATGAAACATCTTACTTCATTGTGATGGTTAATAACTTACTGGAGCTAGATTGTCAT GTGACAGGCTCTCCCCCACCAACTATCATGTGGCTGAAGGATGGCCAGTTAATTGATGAAAGGGATGGATTCAAGATTTTATTAAATGGA CGCAAACTGGTTATTGCTCAGGCTCAAGTGTCAAACACAGGCCTTTATCGGTGCATGGCAGCAAATACTGCTGGAGACCACAAGAAGGAA TTTGAAGTGACTGTTCATGTTCCTCCAACAATCAAGTCCTCAGGCCTTTCTGAGAGAGTTGTGGTAAAATACAAGCCTGTCGCCTTGCAG TGCATAGCCAATGGGATTCCAAATCCTTCCATTACATGGTTAAAAGATGACCAGCCTGTGAACACTGCCCAAGGAAACCTTAAAATACAG TCTTCTGGTCGAGTTCTACAAATTGCCAAAACCCTGTTGGAAGATGCTGGCAGATACACATGTGTGGCTACCAACGCAGCTGGAGAAACA CAACAGCACATTCAACTGCATGTTCATGAACCACCTAGTCTGGAAGATGCTGGAAAAATGCTGAATGAGACTGTGTTGGTGAGCAACCCT GTACAGCTGGAGTGTAAGGCAGCTGGAAATCCTGTGCCTGTTATTACATGGTACAAAGATAATCGTCTACTCTCAGGTTCCACCAGCATG ACTTTCTTGAACAGAGGACAGATCATTGATATTGAAAGTGCCCAGATCTCAGATGCTGGCATATATAAATGCGTGGCCATCAACTCAGCT GGAGCTACAGAGTTATTTTACAGTCTGCAAGTTCATGTGGCCCCATCAATTTCTGGCAGCAATAACATGGTGGCAGTGGTGGTTAATAAC CCGGTGAGGTTAGAATGTGAAGCCAGAGGTATTCCTGCCCCAAGTCTGACCTGGTTGAAAGATGGGAGTCCTGTTTCTAGTTTTTCTAAT GGATTACAGGTTCTCTCTGGTGGTCGAATCCTAGCATTGACCAGTGCACAAATCAGCGACACAGGAAGGTACACCTGCGTGGCAGTGAAT GCTGCTGGAGAAAAGCAAAGGGACATTGACCTCCGAGTATATGTTCCGCCAAATATTATGGGAGAAGAACAGAATGTCTCTGTCCTCATT AGCCAAGCTGTGGAATTACTATGTCAAAGTGATGCTATTCCCCCACCTACTCTTACTTGGTTAAAAGACGGCCACCCCTTGCTGAAGAAA CCAGGCCTCAGTATATCTGAAAATAGAAGTGTGTTAAAGATTGAAGATGCTCAGGTTCAAGACACTGGTCGTTACACTTGTGAAGCAACA AATGTTGCTGGAAAAACTGAAAAAAACTACAATGTCAACATTTGGGTCCCCCCAAATATTGGTGGTTCTGATGAACTTACTCAACTTACA GTCATTGAAGGGAATCTCATTAGTCTGTTGTGTGAATCAAGTGGTATTCCACCCCCAAATCTCATCTGGAAGAAGAAAGGCTCTCCAGTG CTGACTGATTCCATGGGGCGAGTTAGAATTTTATCTGGGGGCAGGCAATTACAAATTTCAATTGCTGAAAAGTCTGATGCAGCACTCTAT TCATGTGTGGCGTCGAATGTTGCTGGGACTGCAAAGAAAGAATACAATCTGCAAGTTTACATTAGACCAACCATAACCAACAGTGGCAGC CACCCTACTGAAATTATTGTGACCCGAGGGAAGAGTATCTCCTTGGAGTGTGAGGTGCAGGGTATTCCACCACCAACAGTGACCTGGATG AAAGATGGCCACCCCTTGATCAAGGCAAAGGGAGTAGAAATACTGGATGAAGGTCACATCCTTCAGCTGAAGAACATTCATGTATCTGAC ACAGGCCGTTATGTGTGTGTTGCTGTGAATGTAGCAGGAATGACTGACAAAAAATATGACTTAAGTGTCCATGCTCCTCCAAGCATCATA GGAAACCACAGGTCACCTGAAAATATTAGTGTGGTAGAAAAGAACTCAGTATCTTTGACTTGTGAAGCTTCTGGAATTCCCCTGCCTTCC ATAACCTGGTTCAAAGATGGGTGGCCTGTCAGCCTTAGCAATTCTGTGAGGATTCTTTCAGGAGGCAGGATGCTACGGCTGATGCAGACC ACAATGGAAGATGCTGGCCAATATACTTGCGTTGTAAGGAATGCAGCTGGTGAAGAAAGAAAAATCTTTGGGCTTTCAGTATTAGTACCA CCTCATATTGTGGGTGAAAATACATTGGAAGATGTGAAGGTAAAAGAGAAACAGAGTGTTACGCTGACTTGTGAAGTGACAGGGAATCCA GTGCCAGAAATTACATGGCACAAAGATGGGCAGCCCCTCCAAGAAGATGAAGCCCATCACATTATATCTGGTGGCCGTTTTCTTCAAATT ACCAATGTCCAGGTGCCACACACTGGAAGATATACATGTTTGGCTTCCAGTCCAGCTGGCCACAAGAGCAGGAGCTTCAGTCTTAATGTA TTTGTATCTCCTACAATTGCTGGTGTAGGTAGTGATGGCAACCCTGAAGATGTCACTGTCATCCTTAACAGCCCTACATCTTTGGTCTGT GAAGCTTATTCATATCCTCCAGCTACCATCACCTGGTTTAAGGATGGCACTCCTTTAGAATCTAACCGAAATATTCGTATTCTTCCAGGA GGCAGAACTCTGCAGATCCTCAATGCACAGGAGGACAATGCTGGAAGATACTCTTGTGTAGCCACGAATGAGGCTGGAGAAATGATAAAG CACTATGAAGTGAAGGTGTACATTCCACCCATAATCAATAAAGGGGACCTTTGGGGGCCAGGTCTTTCCCCTAAAGAAGTGAAGATCAAA GTAAACAACACTCTGACCTTGGAATGTGAAGCGTATGCAATTCCTTCTGCCTCCCTCAGCTGGTACAAGGATGGACAGCCCCTTAAATCC GATGATCATGTTAATATTGCTGCGAATGGACACACACTTCAAATAAAGGAGGCTCAAATATCAGACACCGGACGATATACTTGTGTAGCA TCTAACATTGCAGGTGAAGATGAGTTGGATTTTGATGTGAATATTCAAGTTCCTCCAAGTTTTCAGAAACTCTGGGAAATAGGAAACATG CTAGATACTGGCAGGAATGGTGAAGCCAAAGATGTGATCATCAACAATCCCATTTCTCTTTACTGTGAGACAAATGCTGCTCCCCCTCCT ACACTGACATGGTACAAAGATGGCCACCCTCTGACCTCAAGTGATAAAGTATTGATTTTGCCAGGAGGGCGAGTGTTGCAGATTCCTCGG GCTAAAGTAGAAGATGCTGGGAGATACACATGTGTGGCTGTGAATGAGGCTGGAGAAGATTCCCTTCAATATGATGTCCGTGTACTCGTG CCGCCAATTATCAAGGGAGCAAATAGTGATCTCCCTGAAGAGGTCACCGTGCTGGTGAACAAGAGTGCACTGATAGAGTGTTTATCCAGT GGCAGCCCAGCACCAAGGAATTCCTGGCAGAAAGATGGACAGCCCTTGCTAGAAGATGACCATCATAAATTTCTATCTAATGGACGAATT CTGCAGATTCTGAATACTCAAATAACAGATATCGGCAGGTATGTGTGTGTTGCTGAGAACACAGCTGGGAGTGCCAAAAAATATTTTAAC CTCAATGTTCATGTTCCTCCAAGTGTCATTGGTCCTAAATCTGAAAATCTTACCGTCGTGGTGAACAATTTCATCTCTTTGACCTGTGAG GTCTCTGGTTTTCCACCTCCTGACCTCAGCTGGCTCAAGAATGAACAGCCCATCAAACTGAACACAAATACTCTCATTGTGCCTGGTGGT CGAACTCTACAGATTATTCGGGCCAAGGTATCAGATGGTGGTGAATACACTTGTATAGCTATCAATCAAGCTGGCGAAAGCAAGAAAAAG TTTTCCCTGACTGTTTATGTGCCCCCAAGCATTAAAGACCATGACAGTGAATCTCTTTCTGTAGTTAATGTAAGAGAGGGAACTTCTGTG TCTTTGGAGTGTGAGTCGAACGCTGTGCCACCTCCAGTCATCACTTGGTATAAGAATGGGCGGATGATAACAGAGTCTACTCATGTGGAG ATTTTAGCTGATGGACAAATGCTACACATTAAGAAAGCTGAGGTATCTGACACAGGCCAGTATGTATGTAGAGCTATAAATGTAGCAGGA CGGGATGATAAAAATTTCCACCTCAATGTATATGTGCCACCCAGTATTGAAGGACCTGAAAGAGAAGTGATTGTGGAGACGATCAGCAAT CCTGTGACATTAACATGTGATGCCACTGGGATCCCACCTCCCACGATAGCATGGTTAAAGAACCACAAGCGCATAGAAAATTCTGACTCA CTGGAAGTTCGTATTTTGTCTGGAGGTAGCAAACTCCAGATTGCCCGGTCTCAGCATTCAGATAGTGGAAACTATACATGTATTGCTTCA AATATGGAGGGAAAAGCCCAGAAATATTACTTTCTTTCAATTCAAGTTCCTCCAAGTGTTGCTGGTGCTGAAATTCCAAGTGATGTCAGT GTCCTTCTAGGAGAAAATGTTGAGCTGGTCTGCAATGCAAATGGCATTCCTACTCCACTTATTCAATGGCTTAAAGATGGAAAGCCCATA GCTAGTGGTGAAACAGAAAGAATCCGAGTGAGTGCAAATGGCAGCACATTAAACATTTATGGAGCTCTTACATCTGACACGGGGAAATAC ACATGTGTTGCTACTAATCCCGCTGGAGAAGAAGACCGAATTTTTAACTTGAATGTCTATGTTACACCTACAATTAGGGGTAATAAAGAT GAAGCAGAGAAACTAATGACTTTAGTGGATACTTCAATAAATATTGAATGCAGAGCCACAGGGACGCCTCCACCACAGATAAACTGGCTG AAGAATGGACTTCCTCTGCCTCTCTCCTCCCATATCCGGTTACTGGCAGCAGGACAAGTTATCAGGATTGTGAGAGCTCAGGTGTCTGAT GTCGCTGTGTATACTTGTGTGGCCTCCAACAGAGCTGGGGTGGATAATAAGCATTACAATCTTCAAGTGTTTGCACCACCAAATATGGAC AATTCAATGGGGACAGAGGAAATCACAGTTCTCAAAGGTAGTTCCACCTCTATGGCATGCATTACTGATGGAACCCCAGCTCCCAGTATG GCCTGGCTTAGAGATGGCCAGCCTCTGGGGCTTGATGCCCATCTGACAGTCAGCACCCATGGAATGGTCCTGCAGCTCCTCAAAGCAGAG ACTGAAGATTCGGGAAAGTACACCTGCATTGCCTCAAATGAAGCTGGAGAAGTCAGCAAGCACTTTATCCTCAAGGTCCTAGAACCACCT CACATTAATGGATCTGAAGAACATGAAGAGATATCAGTAATTGTTAATAACCCACTTGAACTTACCTGCATTGCTTCTGGAATCCCAGCC CCTAAAATGACCTGGATGAAAGATGGCCGGCCCCTTCCACAGACGGATCAAGTGCAAACTCTAGGAGGAGGAGAGGTTCTTCGAATTTCT ACTGCTCAGGTGGAGGATACAGGAAGATATACATGTCTGGCATCCAGTCCTGCAGGAGATGATGATAAGGAATATCTAGTGAGAGTGCAT GTACCTCCTAATATTGCTGGAACTGATGAGCCCCGGGATATCACTGTGTTACGGAACAGACAAGTGACATTGGAATGCAAGTCAGATGCA GTGCCCCCACCTGTAATTACTTGGCTCAGAAATGGAGAACGGTTACAGGCAACACCTCGAGTGCGAATCCTATCTGGAGGGAGATACTTG CAAATCAACAATGCTGACCTAGGTGATACAGCCAATTATACCTGTGTTGCCAGCAACATTGCAGGAAAGACTACAAGAGAATTTATTCTC ACTGTAAATGTTCCTCCAAACATAAAGGGGGGCCCCCAGAGCCTTGTAATTCTTTTAAATAAGTCAACTGTATTGGAATGCATCGCTGAA GGTGTGCCAACTCCAAGGATAACATGGAGAAAGGATGGAGCTGTTCTAGCTGGGAATCATGCAAGATATTCCATCTTGGAAAATGGATTC CTTCATATTCAATCAGCACATGTCACTGACACTGGACGGTATTTGTGTATGGCCACCAATGCTGCTGGAACAGATCGCAGGCGAATAGAT TTACAGGTCCATGTTCCTCCATCTATTGCTCCGGGTCCTACCAACATGACTGTAATAGTAAATGTTCAAACTACTCTGGCTTGTGAGGCT ACTGGGATACCAAAACCATCAATCAATTGGAGAAAAAATGGGCATCTTCTTAATGTGGATCAAAATCAGAACTCATACAGGCTCCTTTCT TCAGGTTCACTAGTAATTATTTCCCCTTCTGTGGATGACACTGCAACCTATGAATGTACTGTGACAAACGGTGCTGGAGATGATAAAAGA ACTGTGGATCTCACTGTCCAAGTTCCACCTTCCATAGCTGATGAGCCTACAGATTTCCTAGTAACCAAACATGCCCCAGCAGTAATTACC TGCACTGCTTCGGGAGTTCCATTTCCCTCAATTCACTGGACCAAAAATGGTATAAGACTGCTTCCCAGGGGAGATGGCTATAGAATTCTG TCCTCAGGAGCAATTGAAATACTTGCCACCCAATTAAACCATGCTGGAAGATACACTTGTGTCGCTAGGAATGCGGCTGGCTCTGCACAT CGACACGTGACCCTTCATGTTCATGAGCCTCCAGTCATTCAGCCCCAACCAAGTGAACTACACGTCATTCTGAACAATCCTATTTTATTA CCATGTGAAGCAACAGGGACACCCAGTCCTTTCATTACTTGGCAAAAAGAAGGCATCAATGTTAACACTTCAGGCAGAAACCATGCAGTT CTTCCTAGTGGCGGCTTACAGATCTCCAGAGCTGTCCGAGAGGATGCTGGCACTTACATGTGTGTGGCCCAGAACCCGGCTGGTACAGCC TTGGGCAAAATCAAGTTAAATGTCCAAGTTCCTCCAGTCATTAGCCCTCATCTAAAGGAATATGTTATTGCTGTGGACAAGCCCATCACG TTATCCTGTGAAGCAGATGGCCTCCCTCCGCCTGACATTACATGGCATAAAGATGGGCGTGCAATTGTGGAATCTATCCGCCAGCGCGTC CTCAGCTCTGGCTCTCTGCAAATAGCATTTGTCCAGCCTGGTGATGCTGGCCATTACACGTGCATGGCAGCCAATGTAGCAGGATCAAGC AGCACAAGCACCAAGCTCACCGTCCATGTACCACCCAGGATCAGAAGTACAGAAGGACACTACACGGTCAATGAGAATTCACAAGCCATT CTTCCATGCGTAGCTGATGGAATCCCCACACCAGCAATTAACTGGAAAAAAGACAATGTTCTTTTAGCTAACTTGTTAGGAAAATACACT GCTGAACCATATGGAGAACTCATTTTAGAAAATGTTGTGCTGGAGGATTCTGGCTTCTATACCTGTGTTGCTAACAATGCTGCAGGTGAA GATACACACACTGTCAGCCTGACTGTGCATGTTCTCCCCACTTTTACTGAACTTCCTGGAGACGTGTCATTAAATAAAGGAGAACAGCTA CGATTAAGCTGTAAAGCTACTGGTATTCCATTGCCCAAATTAACATGGACCTTCAATAACAATATTATTCCAGCCCACTTTGACAGTGTG AATGGACACAGTGAACTTGTTATTGAAAGAGTGTCAAAAGAGGATTCAGGTACTTATGTGTGCACCGCAGAGAACAGCGTTGGCTTTGTG AAGGCAATTGGATTTGTTTATGTGAAAGAACCTCCAGTCTTCAAAGGTGATTATCCTTCTAACTGGATTGAACCACTTGGTGGGAATGCA ATCCTGAATTGTGAGGTGAAAGGAGACCCCACCCCAACCATCCAGTGGAACAGAAAGGGAGTGGATATTGAAATTAGCCACAGAATCCGG CAACTGGGCAATGGCTCCCTGGCCATCTATGGCACTGTTAATGAAGATGCCGGTGACTATACATGTGTAGCTACCAATGAAGCTGGGGTG GTGGAGCGCAGCATGAGTCTGACTCTGCAAAGTCCTCCTATTATCACTCTTGAGCCAGTGGAAACTGTTATTAATGCTGGTGGCAAAATC ATATTGAATTGTCAGGCAACTGGAGAGCCTCAACCAACCATTACATGGTCCCGTCAAGGGCACTCTATTTCCTGGGATGACCGGGTTAAC GTGTTGTCCAACAACTCATTATATATTGCTGATGCTCAGAAAGAAGATACCTCTGAATTTGAATGTGTTGCTCGAAACTTAATGGGTTCT GTCCTTGTCAGAGTGCCAGTCATAGTCCAGGTTCATGGTGGATTTTCCCAGTGGTCTGCATGGAGAGCCTGCAGTGTCACCTGTGGAAAA GGCATCCAAAAGAGGAGTCGTCTGTGCAACCAGCCCCTTCCAGCCAATGGTGGGAAGCCCTGCCAAGGTTCAGATTTGGAAATGCGAAAC TGTCAAAATAAGCCTTGTCCAGTGGATGGTAGCTGGTCGGAATGGAGTCTTTGGGAAGAATGCACAAGGAGCTGTGGACGCGGCAACCAA ACCAGGACCAGGACTTGCAATAATCCATCAGTTCAGCATGGTGGGCGGCCATGTGAAGGGAATGCTGTGGAAATAATTATGTGCAACATT AGGCCTTGCCCAGTTCATGGAGCATGGAGCGCTTGGCAGCCTTGGGGAACATGCAGCGAAAGTTGTGGGAAAGGTACTCAGACAAGAGCA AGACTTTGTAATAACCCACCACCAGCGTTTGGTGGGTCCTACTGTGATGGAGCAGAAACACAGATGCAAGTTTGCAATGAAAGAAATTGT CCAATTCATGGCAAGTGGGCGACTTGGGCCAGTTGGAGTGCCTGTTCTGTGTCATGTGGAGGAGGTGCCAGACAGAGAACAAGGGGCTGC TCCGACCCTGTGCCCCAGTATGGAGGAAGGAAATGCGAAGGGAGTGATGTCCAGAGTGATTTTTGCAACAGTGACCCTTGCCCAACCCAT GGTAACTGGAGTCCTTGGAGTGGCTGGGGAACATGCAGCCGGACGTGTAACGGAGGGCAGATGCGGCGGTACCGCACATGTGATAACCCT CCTCCCTCCAATGGGGGAAGAGCTTGTGGGGGACCAGACTCCCAGATCCAGAGGTGCAACACTGACATGTGTCCTGTGGATGGAAGTTGG GGAAGCTGGCATAGTTGGAGCCAGTGCTCTGCCTCCTGTGGAGGAGGTGAAAAGACTCGGAAGCGGCTGTGCGACCATCCTGTGCCAGTT AAAGGTGGCCGTCCCTGTCCCGGAGACACTACTCAGGTGACCAGGTGCAATGTACAAGCATGTCCAGGTGGGCCCCAGCGAGCCAGAGGA AGTGTTATTGGAAATATTAATGATGTTGAATTTGGAATTGCTTTCCTTAATGCCACAATAACTGATAGCCCTAACTCTGATACTAGAATA ATACGTGCCAAAATTACCAATGTACCTCGTAGTCTTGGTTCAGCAATGAGAAAGATAGTTTCTATTCTAAATCCCATTTATTGGACAACA GCAAAGGAAATAGGAGAAGCAGTCAATGGCTTTACCCTCACCAATGCAGTCTTCAAAAGAGAAACTCAAGTGGAATTTGCAACTGGAGAA ATCTTGCAGATGAGTCATATTGCCCGGGGCTTGGATTCCGATGGTTCTTTGCTGCTAGATATCGTTGTGAGTGGCTATGTCCTACAGCTT CAGTCACCTGCTGAAGTCACTGTAAAGGATTACACAGAGGACTACATTCAAACAGGTCCTGGGCAGCTGTACGCCTACTCAACCCGGCTG TTCACCATTGATGGCATCAGCATCCCATACACATGGAACCACACCGTTTTCTATGATCAGGCACAGGGAAGAATGCCTTTCTTGGTTGAA ACACTTCATGCATCCTCTGTGGAATCTGACTATAACCAGATAGAAGAGACACTGGGTTTTAAAATTCATGCTTCAATATCCAAAGGAGAT CGCAGTAATCAGTGCCCCTCCGGGTTTACCTTAGACTCAGTTGGACCTTTTTGTGCTGATGAGGATGAATGTGCAGCAGGGAATCCCTGC TCCCATAGCTGCCACAATGCCATGGGGACTTACTACTGCTCCTGCCCTAAAGGCCTCACCATAGCTGCAGATGGAAGAACTTGTCAAGAT ATTGATGAGTGTGCTTTGGGTAGGCATACCTGCCACGCTGGTCAGGACTGTGACAATACGATTGGATCTTATCGCTGTGTGGTCCGTTGT GGAAGTGGCTTTCGAAGAACCTCTGATGGGCTGAGTTGTCAAGATATTAATGAATGTCAAGAATCCAGCCCCTGTCACCAGCGCTGTTTC AATGCCATAGGAAGTTTCCATTGTGGATGTGAACCTGGGTATCAGCTCAAAGGCAGAAAATGCATGGATGTGAACGAGTGTAGACAAAAT GTATGCAGACCAGATCAGCACTGTAAGAACACCCGTGGTGGCTATAAGTGCATTGATCTTTGTCCAAATGGAATGACCAAGGCAGAAAAT GGAACCTGTATTGATATTGATGAATGTAAAGATGGGACCCATCAGTGCAGATATAACCAGATATGTGAGAATACAAGAGGCAGCTATCGT TGTGTATGCCCAAGAGGTTATCGGTCTCAAGGAGTTGGAAGACCCTGCATGGATATTGATGAATGTGAAAATACAGATGCCTGCCAGCAT GAGTGTAAGAATACCTTTGGAAGTTATCAGTGCATCTGCCCACCTGGCTATCAACTCACACACAATGGAAAGACATGCCAAGATATCGAT GAATGTCTGGAGCAGAATGTGCACTGTGGACCCAATCGCATGTGCTTCAACATGAGAGGAAGCTACCAGTGCATCGATACACCCTGTCCA CCCAACTACCAACGGGATCCTGTTTCAGGGTTCTGCCTCAAGAACTGTCCACCCAATGATTTGGAATGTGCCTTGAGCCCATATGCCTTG GAATACAAACTCGTCTCCCTCCCATTTGGAATAGCCACCAATCAAGATTTAATCCGGCTGGTTGCATACACACAGGATGGAGTGATGCAT CCCAGGACAACTTTCCTCATGGTAGATGAGGAACAGACTGTTCCTTTTGCCTTGAGGGATGAAAACCTGAAAGGAGTGGTGTATACAACA CGACCACTACGAGAAGCAGAGACCTACCGCATGAGGGTCCGAGCCTCATCCTACAGTGCCAATGGGACCATTGAATATCAGACCACATTC ATAGTTTATATAGCTGTGTCCGCCTATCCATACTAAGGAACTCTCCAAAGCCTATTCCACATATTTAAACCGCATTAATCATGGCAATCA AGCCCCCTTCCAGATTACTGTCTCTTGAACAGTTGCAATCTTGGCAGCTTGAAAATGGTGCTACACTCTGTTTTGTGTGCCTTCCTTGGT ACTTCTGAGGTATTTTCATGATCCCACCATGGTCATATCTTGAAGTATGGTCTAGAAAAGTCCCTTATTATTTTATTTATTACACTGGAG CAGTTACTTCCCAAAGATTATTCTGAACATCTAACAGGACATATCAGTGATGGTTTACAGTAGTGTAGTACCTAAGATCATTTTCCTGAA AGCCAAACCAAACAACGAAAAACAAGAACAACTAATTCAGAATCAAATAGAGTTTTTGAGCATTTGACTATTTTTAGAATCATAAAATTA GTTACTAAGTATTTTGATCAAAGCTTATAAAATAACTTACGGAGATTTTTGTAAGTATTGATACATTATAATAGGACTTGCCTATTTTCA TTTTTAAGAAGAAAAACACCACTCATTTTATAAAATATAGTACAGCTACTATAAGGCTTGTTTGATCCCAAATGGTGCTTATCTTGATTG AACATTCAGAACAAGGATATTATTTTCAGTGATTTTGTGAGATCAGCTGAACCACTTATGATAATAATAATAAAAAAGACTGCTTTGCCC TCACGTCAGTTGTACATGGCATGGAACTTTAAAAATTTTAATATAAACTTTCATCCAGTTAGCTTCATAACTTTTACGTTCCAGAATTTT GTTTATTTTCCTGTCAATGAAAGCAATTTTTAAAGATACCAGTGGGACAGATTTGGTTTTTTAAAAATCTCATGTGTTCAAATTAACATA AATATTACACGTCAATACACTGTACATGGTGGTAATAGACTCTAAGCAATTGCCAAGATGTATTCTATTTTTATGAAGTGTATATATATT ACCTTAGTGTGCATTTTCTATATAATATCTTGATGGACTCTTTTATAAAATTATTTTATAAAAAACAATGTTACACTAAAATCAGCCTAA >92059_92059_2_TMEM2-HMCN1_TMEM2_chr9_74309425_ENST00000396272_HMCN1_chr1_185878469_ENST00000367492_length(amino acids)=5536AA_BP=225 MTITRDEYPSNPMVLRGINQKAAFPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCYPSNTSFQVTFGYLQRQNGSLSK IEEYEPVHSLEELQRKQSERKFYFDSSTGLLFLYLKAKSHRHGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYRKPSVVKRMPAM LTGLCQGCGTRQVVFTSDPHKSYLPVQFQSPDKAETQRGDPSVISVLKWVEEAVQASKVHLLSTDHLEQAVNTWRIPFDPSLKEVTVSLS GPSPMIEIRNPLGKLIKKGFGLHELLNIHNSAKVVNVKEPEAGMWTVKTSSSGRHSVRITGLSTIDFRAGFSRKPTLDFKKTVSRPVQGI PTYVLLNTSGISTPARIDLLELLSISGSSLKTIPVKYYPHRKPYGIWNISDFVPPNEAFFLKVTGYDKDDYLFQRVSSVSFSSIVPDAPK VTMPEKTPGYYLQPGQIPCSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPV IQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPP KVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAP KLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSP PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTV TVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKT TSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKR KVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVA TNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCV ATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYD NGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRAT PEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHL KNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQY LHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEA GGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFK ILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQG NLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLS GSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPV SSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGH PLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKK KGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPP TVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASG IPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCE VTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSP TSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPK EVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLW EIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYD VRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSA KKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAG ESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRA INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNY TCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTS DTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVR AQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQ LLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGE VLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILS GGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSI LENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNS YRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGD GYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSG RNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVES IRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANL LGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA HFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEI SHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISW DDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSD LEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHGAWSAWQPWGTCSESCGKG TQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSD PCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCD HPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDSPNSDTRIIRAKITNVPRSLGSAMRKIVSILNP IYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILQMSHIARGLDSDGSLLLDIVVSGYVLQLQSPAEVTVKDYTEDYIQTGPGQLYA YSTRLFTIDGISIPYTWNHTVFYDQAQGRMPFLVETLHASSVESDYNQIEETLGFKIHASISKGDRSNQCPSGFTLDSVGPFCADEDECA AGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPC HQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENT RGSYRCVCPRGYRSQGVGRPCMDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCI DTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLPFGIATNQDLIRLVAYTQDGVMHPRTTFLMVDEEQTVPFALRDENLKG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TMEM2-HMCN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TMEM2-HMCN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TMEM2-HMCN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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