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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMEM30A-MARCH5 (FusionGDB2 ID:92067)

Fusion Gene Summary for TMEM30A-MARCH5

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM30A-MARCH5
	Fusion gene ID: 92067
		Hgene	Tgene
	Gene symbol	TMEM30A	MARCH5
	Gene ID	55754	54708
	Gene name	transmembrane protein 30A	membrane associated ring-CH-type finger 5
	Synonyms	C6orf67\|CDC50A	MARCH-V\|MARCH5\|MITOL\|RNF153
	Cytomap	6q14.1	10q23.32-q23.33
	Type of gene	protein-coding	protein-coding
	Description	cell cycle control protein 50AP4-ATPase flippase complex beta subunit TMEM30A	E3 ubiquitin-protein ligase MARCH5RING-type E3 ubiquitin transferase MARCH5membrane associated ring finger 5membrane-associated RING finger protein 5membrane-associated RING-CH protein Vmembrane-associated ring finger (C3HC4) 5mitochondrial ubiquiti
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000230461, ENST00000475111, ENST00000370050,	ENST00000467521, ENST00000358935,
Fusion gene scores	* DoF score	8 X 7 X 6=336	6 X 7 X 4=168
	# samples	10	8
	** MAII score	log2(10/336*10)=-1.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TMEM30A [Title/Abstract] AND MARCH5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM30A(75994118)-MARCH5(94109106), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TMEM30A	GO:0006855	drug transmembrane transport	20510206
Hgene	TMEM30A	GO:0015917	aminophospholipid transport	20510206
Hgene	TMEM30A	GO:0045332	phospholipid translocation	20510206
Hgene	TMEM30A	GO:0070863	positive regulation of protein exit from endoplasmic reticulum	21914794
Tgene	MARCH5	GO:0000209	protein polyubiquitination	16936636
Tgene	MARCH5	GO:0051865	protein autoubiquitination	16874301

Fusion gene breakpoints across TMEM30A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MARCH5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-BH-A0DP-11A	TMEM30A	chr6	75994118	-	MARCH5	chr10	94109106	+

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Fusion Gene ORF analysis for TMEM30A-MARCH5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000230461	ENST00000467521	TMEM30A	chr6	75994118	-	MARCH5	chr10	94109106	+
5CDS-3UTR	ENST00000475111	ENST00000467521	TMEM30A	chr6	75994118	-	MARCH5	chr10	94109106	+
In-frame	ENST00000230461	ENST00000358935	TMEM30A	chr6	75994118	-	MARCH5	chr10	94109106	+
In-frame	ENST00000475111	ENST00000358935	TMEM30A	chr6	75994118	-	MARCH5	chr10	94109106	+
intron-3CDS	ENST00000370050	ENST00000358935	TMEM30A	chr6	75994118	-	MARCH5	chr10	94109106	+
intron-3UTR	ENST00000370050	ENST00000467521	TMEM30A	chr6	75994118	-	MARCH5	chr10	94109106	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000230461

TMEM30A

chr6

75994118

ENST00000358935

MARCH5

chr10

94109106

3792

567

1034

339

ENST00000475111

TMEM30A

chr6

75994118

ENST00000358935

MARCH5

chr10

94109106

3772

547

136

1014

292

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000230461	ENST00000358935	TMEM30A	chr6	75994118	-	MARCH5	chr10	94109106	+	0.01853328	0.9814667
ENST00000475111	ENST00000358935	TMEM30A	chr6	75994118	-	MARCH5	chr10	94109106	+	0.00050966	0.99949026

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Fusion Genomic Features for TMEM30A-MARCH5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM30A-MARCH5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:75994118/chr10:94109106)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000230461

2_49

362.0

Topological domain

Cytoplasmic

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000475111

2_49

326.0

Topological domain

Cytoplasmic

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000230461

50_70

362.0

Transmembrane

Helical

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000475111

50_70

326.0

Transmembrane

Helical

Tgene

MARCH5

chr6:75994118

chr10:94109106

ENST00000358935

139_159

123

279.0

Transmembrane

Helical

Tgene

MARCH5

chr6:75994118

chr10:94109106

ENST00000358935

209_229

123

279.0

Transmembrane

Helical

Tgene

MARCH5

chr6:75994118

chr10:94109106

ENST00000358935

238_258

123

279.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000230461

347_361

362.0

Topological domain

Cytoplasmic

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000230461

71_325

362.0

Topological domain

Exoplasmic loop

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000370050

2_49

243.0

Topological domain

Cytoplasmic

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000370050

347_361

243.0

Topological domain

Cytoplasmic

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000370050

71_325

243.0

Topological domain

Exoplasmic loop

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000475111

347_361

326.0

Topological domain

Cytoplasmic

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000475111

71_325

326.0

Topological domain

Exoplasmic loop

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000230461

326_346

362.0

Transmembrane

Helical

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000370050

326_346

243.0

Transmembrane

Helical

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000370050

50_70

243.0

Transmembrane

Helical

Hgene

TMEM30A

chr6:75994118

chr10:94109106

ENST00000475111

326_346

326.0

Transmembrane

Helical

Tgene

MARCH5

chr6:75994118

chr10:94109106

ENST00000358935

99_119

123

279.0

Transmembrane

Helical

Tgene

MARCH5

chr6:75994118

chr10:94109106

ENST00000358935

6_75

123

279.0

Zinc finger

RING-CH-type

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Fusion Gene Sequence for TMEM30A-MARCH5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>92067_92067_1_TMEM30A-MARCH5_TMEM30A_chr6_75994118_ENST00000230461_MARCH5_chr10_94109106_ENST00000358935_length(transcript)=3792nt_BP=567nt
CCCGTCACAGGACAGATGATCAGGGTGCGTCCGCCTTTTCGTTCCCGCTTCTATCCTCCTCCCCTTTCCCCTCCCCATGTCCCTCCTTCT
TCTCCCTCCTCCCTCTCTCCCTCCCTCTGGCGTCTCCAGCCGACTTTCGCTTCCCGTCAGCAGCCTTTGGCGGAAGAGTGTCCCGCCTCT
TCCGCTCTACAGCGGAGGTGGCTGTGGCGGTGGCGCTGGTGGCTGCGGCGGCGGCGGCGGCAGCGGCGCTCGAGCGGTTCCTGTCAGGGT
CAGCCGGCGGGCCCCCTGGGTGGTCCACCTGCAAATCGCGGAGCGGCGCCCCAGGGATCGATGGCGATGAACTATAACGCGAAGGATGAA
GTGGACGGTGGGCCCCCGTGTGCTCCGGGGGGCACCGCGAAGACTCGGAGACCGGATAACACGGCCTTCAAACAGCAACGGCTGCCAGCT
TGGCAGCCCATCCTTACGGCTGGCACGGTGCTACCTATTTTCTTCATCATCGGTCTCATCTTCATTCCCATCGGCATTGGCATTTTTGTC
ACCTCCAACAACATCCGCGAGATCGAGGTTGTAGGTCATAAAGAAGGTCTGGATGTTATGGAGAGAGCTGATCCTTTATTCCTTTTAATT
GGACTTCCTACTATTCCTGTCATGCTGATATTAGGCAAGATGATTCGCTGGGAGGACTATGTGCTTAGACTGTGGCGCAAATACTCGAAT
AAACTACAAATTTTAAATAGTATATTTCCAGGGATAGGTTGTCCTGTTCCTCGAATTCCAGCTGAGGCCAATCCTTTAGCAGATCATGTC
TCTGCTACTCGAATCTTGTGTGGAGCCCTTGTCTTTCCTACTATTGCTACAATAGTTGGTAAATTGATGTTCAGTAGTGTTAACTCTAAT
TTACAAAGGACAATCTTGGGTGGAATTGCGTTTGTTGCCATAAAAGGAGCATTTAAAGTTTACTTCAAACAGCAGCAATATTTACGACAG
GCACACCGCAAAATTCTGAATTATCCAGAACAAGAAGAAGCATAAAACTGACTTCTGGTTGTTCTGCAGTTCTCTCATCCTTATGAATCT
GTTGTGTTGTTTTGATTCCATCATTAATGCACTTGTGGAGACTTGTGATAAGCTGCTGCTCCTATATTTTTTAAGAAATATAATAAAGCA
CTTAGGGCAGGGGAAATCATCTCGGTAATCATGGAACCTAAGGATGTGATTTGTTTTCATTGTTTGTATGTACTACTTTTATGGCAGTCA
TATGAACCATTATCTTAGCATGGTAAACCTGGGTTTTGTTCATATTTTCTCCAGACAGAAATGCAAAGATCAAACTGTGCAAATATTAAA
AAAATGCACATGCTGTTTTATTCAAATGCCTCTTTTGTACATGTTCATGTTTAGTGTTTTCTCAGAATCAGCAACTCAAGGTACTATGAG
GATTTTTCTCACTGACATAATTTGATTACATACTAAATAAGAGGATATGTTAATATGAGGAAATGTAAATTAAATTAGTTATAAATAAAT
AACCAAAAATGTATGTAAACATTCAAATGATTATCTGAACAAATGAGATTTTGTGGTGTTTTCTTTAACCCATGTGATGTCCTCCAAAAT
GTGTAGGGTAAAAATTCACAGGGCTTCCAGATCACTTTTTCAATATTAAATTTTATTTACATAATGTTGACATCTCATACTTCATGAAGT
AATTTTGACTCATGCAGTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGTGTGTTTCAGTGTTTCATCAGGTCCTTC
CATCTCTGGGAGTTTTTTCAACCCATATTTCTAGAAATTACAGCTGCCAGTTTATAGTAGTTTGAGCAGAGGATGATTTGCAAAAATAAA
AATAAAGTTATTTTACTCTCCTCTTGCATTGATTCAGTTATTGAGATATTCGTTGATCACCTCCTATTTCCCAGGCACTGTGCAGAGTGC
TGTAGGACATAGTGGTGAACAAGACAGACTTGGTCCAAGCTCTTACAGAGTTGACAGTCTAGTTTCAGCACATAGAAAACCAGCAGTGAA
TAAACCAAGGTGAGGCCTTGAGCTCTTTGTTTTTATATTAATGAGGAGAAAAGTATGAAAACAAGAAGTCTTAAGTAAATATTGAGGTCA
TTGTTTTTGGCTTAAGTTTATTATAGAAAATCAACACTAATGTTTTTAGATTTTAATTGTCCTATTGATGAGGCTAGCACCTTAATCACT
GTTTAGTTTTGTATTCATTTTTAAAAGCAATTATTGAAGCCATTTTCAATAGATTGGCCATTTTAATGTTCAGCAACCTGAATGGTTATT
TTTGTTAATTAAAATTAAATTTTTAAGAGATATTTTCAAAACCCTATTTATTTTCTTGTTCACAGTAATGCATGTCAATAATAAATGTTT
CCCCTTACTGATAAGCGGCCACTTTAGGAGTGTAGCAAATATAGATTGAGCTATGTTAGTTTGCAATAATATATGTTAACTTTAGTAATT
AAAGACTGGTTTCTATAGTATGAATGTCTTAATTTTGAGTTATATGATGTTTATTTGAATGACTGTTGAACATTCAAATTTGTATTATTT
GGAGATGAAGATTTGACTAACAGTGAGCCTTATTAAGAACACTACTACAGTTCTGAAGGGGAAATATAACATCTATGGTTATATATTTTA
AAAACTTAGATTATAGGCTGTAATTATAAAATATATTGGCTTTTGTTTTCAATGTGAAAGATACATTAAATGGACACATATCTTGCAAAA
TTTTGTTGTATAGAACAGTTTTTAGGCAGCCTTTACTAAAGTTATGCAAACACACAGTTCCCCATTTACTACATTAATGCCCTTGACAGG
GAGTAGCTGCTTGGTTTTATAGGTATTAGGGCTCATGAAGGCCGGGGAACAACTCTAATCCTTTTGGGGCAGGAGGGAGGGTTTTTTTAG
GGTTGCGGGGAGGGAACTGCAAGTGCCTGAGGACCAGAGTGGCCTCTAGCCCCGAATTGAACACTTTTAAACCTAAAGAGCCTTATTATT
ATTAGCTCGAGAAATACCACATGCCAGTCTTCCCAGGAAGGTGACCTGCCTGACCATGAAGCAACAAAAGAGCATAGGCAGACTTAAAGT
TGGATAGACCTGGGTTCAAATCATAGTTCAGCTTTCAATAACTGTATGTATGATTTTGGCTAAAGGATTTGACTTTCTCTCAACTGCAGT
TTTCTTAATCTTTGAAATGCAAATAATGTTTATCTCAGAAGACTATTTCTAGGATTAACTGAGAGATTAAAGGAACAGCAGCACTTAGGC
TCAAAATCGCCCCTACAAAGCAGTAGTTGTTTCTTAATTGCTAAGTAATCTGTTTGCACTCTAGGAAAAGTAAATGGAGAGGTAAAAGAA
AGGCATTGGGGACAAATGAAAGAGATGATGTAGATTTTTCGGATGGGTGGGTATATTTTATTTTCCAGTTTATTTTCATATTTCTTTACT
GTGTTATTTCTGGAAACTTTAATGTTTTAAACCTCTTTTATAAAATTCAATGACGACTACTAGAATTCTTTTCAAAAGTTAACTTATCTC
CAAAGTGGCTGAAAATATTGTTTACCATTACATGATTATGAAATGACTGTGAAGAATATAAAATTAAACTTAGTGACTTAATTAGTCACT
GCCTTGCTAACTTTGCTGTAATTTTTTTAAACGTCTTGTTTTTAATATAGCAAACTATCTCAATACTGGCTGGATTAGGTTAAATAAAGA

>92067_92067_1_TMEM30A-MARCH5_TMEM30A_chr6_75994118_ENST00000230461_MARCH5_chr10_94109106_ENST00000358935_length(amino acids)=339AA_BP=184
MIRVRPPFRSRFYPPPLSPPHVPPSSPSSLSPSLWRLQPTFASRQQPLAEECPASSALQRRWLWRWRWWLRRRRRQRRSSGSCQGQPAGP
LGGPPANRGAAPQGSMAMNYNAKDEVDGGPPCAPGGTAKTRRPDNTAFKQQRLPAWQPILTAGTVLPIFFIIGLIFIPIGIGIFVTSNNI
REIEVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRI

--------------------------------------------------------------
>92067_92067_2_TMEM30A-MARCH5_TMEM30A_chr6_75994118_ENST00000475111_MARCH5_chr10_94109106_ENST00000358935_length(transcript)=3772nt_BP=547nt
CAGGGTGCGTCCGCCTTTTCGTTCCCGCTTCTATCCTCCTCCCCTTTCCCCTCCCCATGTCCCTCCTTCTTCTCCCTCCTCCCTCTCTCC
CTCCCTCTGGCGTCTCCAGCCGACTTTCGCTTCCCGTCAGCAGCCTTTGGCGGAAGAGTGTCCCGCCTCTTCCGCTCTACAGCGGAGGTG
GCTGTGGCGGTGGCGCTGGTGGCTGCGGCGGCGGCGGCGGCAGCGGCGCTCGAGCGGTTCCTGTCAGGGTCAGCCGGCGGGCCCCCTGGG
TGGTCCACCTGCAAATCGCGGAGCGGCGCCCCAGGGATCGATGGCGATGAACTATAACGCGAAGGATGAAGTGGACGGTGGGCCCCCGTG
TGCTCCGGGGGGCACCGCGAAGACTCGGAGACCGGATAACACGGCCTTCAAACAGCAACGGCTGCCAGCTTGGCAGCCCATCCTTACGGC
TGGCACGGTGCTACCTATTTTCTTCATCATCGGTCTCATCTTCATTCCCATCGGCATTGGCATTTTTGTCACCTCCAACAACATCCGCGA
GATCGAGGTTGTAGGTCATAAAGAAGGTCTGGATGTTATGGAGAGAGCTGATCCTTTATTCCTTTTAATTGGACTTCCTACTATTCCTGT
CATGCTGATATTAGGCAAGATGATTCGCTGGGAGGACTATGTGCTTAGACTGTGGCGCAAATACTCGAATAAACTACAAATTTTAAATAG
TATATTTCCAGGGATAGGTTGTCCTGTTCCTCGAATTCCAGCTGAGGCCAATCCTTTAGCAGATCATGTCTCTGCTACTCGAATCTTGTG
TGGAGCCCTTGTCTTTCCTACTATTGCTACAATAGTTGGTAAATTGATGTTCAGTAGTGTTAACTCTAATTTACAAAGGACAATCTTGGG
TGGAATTGCGTTTGTTGCCATAAAAGGAGCATTTAAAGTTTACTTCAAACAGCAGCAATATTTACGACAGGCACACCGCAAAATTCTGAA
TTATCCAGAACAAGAAGAAGCATAAAACTGACTTCTGGTTGTTCTGCAGTTCTCTCATCCTTATGAATCTGTTGTGTTGTTTTGATTCCA
TCATTAATGCACTTGTGGAGACTTGTGATAAGCTGCTGCTCCTATATTTTTTAAGAAATATAATAAAGCACTTAGGGCAGGGGAAATCAT
CTCGGTAATCATGGAACCTAAGGATGTGATTTGTTTTCATTGTTTGTATGTACTACTTTTATGGCAGTCATATGAACCATTATCTTAGCA
TGGTAAACCTGGGTTTTGTTCATATTTTCTCCAGACAGAAATGCAAAGATCAAACTGTGCAAATATTAAAAAAATGCACATGCTGTTTTA
TTCAAATGCCTCTTTTGTACATGTTCATGTTTAGTGTTTTCTCAGAATCAGCAACTCAAGGTACTATGAGGATTTTTCTCACTGACATAA
TTTGATTACATACTAAATAAGAGGATATGTTAATATGAGGAAATGTAAATTAAATTAGTTATAAATAAATAACCAAAAATGTATGTAAAC
ATTCAAATGATTATCTGAACAAATGAGATTTTGTGGTGTTTTCTTTAACCCATGTGATGTCCTCCAAAATGTGTAGGGTAAAAATTCACA
GGGCTTCCAGATCACTTTTTCAATATTAAATTTTATTTACATAATGTTGACATCTCATACTTCATGAAGTAATTTTGACTCATGCAGTCG
TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGTGTGTTTCAGTGTTTCATCAGGTCCTTCCATCTCTGGGAGTTTTTTCA
ACCCATATTTCTAGAAATTACAGCTGCCAGTTTATAGTAGTTTGAGCAGAGGATGATTTGCAAAAATAAAAATAAAGTTATTTTACTCTC
CTCTTGCATTGATTCAGTTATTGAGATATTCGTTGATCACCTCCTATTTCCCAGGCACTGTGCAGAGTGCTGTAGGACATAGTGGTGAAC
AAGACAGACTTGGTCCAAGCTCTTACAGAGTTGACAGTCTAGTTTCAGCACATAGAAAACCAGCAGTGAATAAACCAAGGTGAGGCCTTG
AGCTCTTTGTTTTTATATTAATGAGGAGAAAAGTATGAAAACAAGAAGTCTTAAGTAAATATTGAGGTCATTGTTTTTGGCTTAAGTTTA
TTATAGAAAATCAACACTAATGTTTTTAGATTTTAATTGTCCTATTGATGAGGCTAGCACCTTAATCACTGTTTAGTTTTGTATTCATTT
TTAAAAGCAATTATTGAAGCCATTTTCAATAGATTGGCCATTTTAATGTTCAGCAACCTGAATGGTTATTTTTGTTAATTAAAATTAAAT
TTTTAAGAGATATTTTCAAAACCCTATTTATTTTCTTGTTCACAGTAATGCATGTCAATAATAAATGTTTCCCCTTACTGATAAGCGGCC
ACTTTAGGAGTGTAGCAAATATAGATTGAGCTATGTTAGTTTGCAATAATATATGTTAACTTTAGTAATTAAAGACTGGTTTCTATAGTA
TGAATGTCTTAATTTTGAGTTATATGATGTTTATTTGAATGACTGTTGAACATTCAAATTTGTATTATTTGGAGATGAAGATTTGACTAA
CAGTGAGCCTTATTAAGAACACTACTACAGTTCTGAAGGGGAAATATAACATCTATGGTTATATATTTTAAAAACTTAGATTATAGGCTG
TAATTATAAAATATATTGGCTTTTGTTTTCAATGTGAAAGATACATTAAATGGACACATATCTTGCAAAATTTTGTTGTATAGAACAGTT
TTTAGGCAGCCTTTACTAAAGTTATGCAAACACACAGTTCCCCATTTACTACATTAATGCCCTTGACAGGGAGTAGCTGCTTGGTTTTAT
AGGTATTAGGGCTCATGAAGGCCGGGGAACAACTCTAATCCTTTTGGGGCAGGAGGGAGGGTTTTTTTAGGGTTGCGGGGAGGGAACTGC
AAGTGCCTGAGGACCAGAGTGGCCTCTAGCCCCGAATTGAACACTTTTAAACCTAAAGAGCCTTATTATTATTAGCTCGAGAAATACCAC
ATGCCAGTCTTCCCAGGAAGGTGACCTGCCTGACCATGAAGCAACAAAAGAGCATAGGCAGACTTAAAGTTGGATAGACCTGGGTTCAAA
TCATAGTTCAGCTTTCAATAACTGTATGTATGATTTTGGCTAAAGGATTTGACTTTCTCTCAACTGCAGTTTTCTTAATCTTTGAAATGC
AAATAATGTTTATCTCAGAAGACTATTTCTAGGATTAACTGAGAGATTAAAGGAACAGCAGCACTTAGGCTCAAAATCGCCCCTACAAAG
CAGTAGTTGTTTCTTAATTGCTAAGTAATCTGTTTGCACTCTAGGAAAAGTAAATGGAGAGGTAAAAGAAAGGCATTGGGGACAAATGAA
AGAGATGATGTAGATTTTTCGGATGGGTGGGTATATTTTATTTTCCAGTTTATTTTCATATTTCTTTACTGTGTTATTTCTGGAAACTTT
AATGTTTTAAACCTCTTTTATAAAATTCAATGACGACTACTAGAATTCTTTTCAAAAGTTAACTTATCTCCAAAGTGGCTGAAAATATTG
TTTACCATTACATGATTATGAAATGACTGTGAAGAATATAAAATTAAACTTAGTGACTTAATTAGTCACTGCCTTGCTAACTTTGCTGTA

>92067_92067_2_TMEM30A-MARCH5_TMEM30A_chr6_75994118_ENST00000475111_MARCH5_chr10_94109106_ENST00000358935_length(amino acids)=292AA_BP=137
MAEECPASSALQRRWLWRWRWWLRRRRRQRRSSGSCQGQPAGPLGGPPANRGAAPQGSMAMNYNAKDEVDGGPPCAPGGTAKTRRPDNTA
FKQQRLPAWQPILTAGTVLPIFFIIGLIFIPIGIGIFVTSNNIREIEVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVL
RLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTILGGIAFVAIKGAFKVYF

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Fusion Gene PPI Analysis for TMEM30A-MARCH5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TMEM30A-MARCH5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TMEM30A-MARCH5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source