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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMEM38A-CHERP (FusionGDB2 ID:92084)

Fusion Gene Summary for TMEM38A-CHERP

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM38A-CHERP
	Fusion gene ID: 92084
		Hgene	Tgene
	Gene symbol	TMEM38A	CHERP
	Gene ID	79041	10523
	Gene name	transmembrane protein 38A	calcium homeostasis endoplasmic reticulum protein
	Synonyms	TRIC-A\|TRICA	DAN16\|SCAF6\|SRA1
	Cytomap	19p13.11	19p13.11
	Type of gene	protein-coding	protein-coding
	Description	trimeric intracellular cation channel type A	calcium homeostasis endoplasmic reticulum proteinERPROT 213-21ERPROT213-21SR-related CTD associated factor 6protein with polyglutamine repeat
	Modification date	20200313	20200313
	UniProtAcc	.	Q8IWX8
	Ensembl transtripts involved in fusion gene	ENST00000187762,	ENST00000544299, ENST00000198939, ENST00000546361,
Fusion gene scores	* DoF score	6 X 5 X 3=90	4 X 3 X 4=48
	# samples	6	5
	** MAII score	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: TMEM38A [Title/Abstract] AND CHERP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM38A(16772152)-CHERP(16646447), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CHERP	GO:0006874	cellular calcium ion homeostasis	10794731
Tgene	CHERP	GO:0008285	negative regulation of cell proliferation	10794731

Fusion gene breakpoints across TMEM38A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CHERP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-D9-A4Z5-01A	TMEM38A	chr19	16772152	+	CHERP	chr19	16646447	-

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Fusion Gene ORF analysis for TMEM38A-CHERP

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000187762	ENST00000544299	TMEM38A	chr19	16772152	+	CHERP	chr19	16646447	-
In-frame	ENST00000187762	ENST00000198939	TMEM38A	chr19	16772152	+	CHERP	chr19	16646447	-
In-frame	ENST00000187762	ENST00000546361	TMEM38A	chr19	16772152	+	CHERP	chr19	16646447	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000187762

TMEM38A

chr19

16772152

ENST00000546361

CHERP

chr19

16646447

4037

215

2766

891

ENST00000187762

TMEM38A

chr19

16772152

ENST00000198939

CHERP

chr19

16646447

4063

215

2799

902

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000187762	ENST00000546361	TMEM38A	chr19	16772152	+	CHERP	chr19	16646447	-	0.02015641	0.9798436
ENST00000187762	ENST00000198939	TMEM38A	chr19	16772152	+	CHERP	chr19	16646447	-	0.018791445	0.98120856

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Fusion Genomic Features for TMEM38A-CHERP

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM38A-CHERP

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:16772152/chr19:16646447)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CHERP Q8IWX8
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Involved in calcium homeostasis, growth and proliferation. {ECO:0000269\|PubMed:10794731, ECO:0000269\|PubMed:12656674}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

1_18

300.0

Topological domain

Lumenal

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

19_39

300.0

Transmembrane

Helical%3BName%3D1

Tgene

CHERP

chr19:16772152

chr19:16646447

ENST00000546361

279_346

917.0

Compositional bias

Gln-rich

Tgene

CHERP

chr19:16772152

chr19:16646447

ENST00000546361

355_682

917.0

Compositional bias

Pro-rich

Tgene

CHERP

chr19:16772152

chr19:16646447

ENST00000546361

718_816

917.0

Compositional bias

Arg-rich

Tgene

CHERP

chr19:16772152

chr19:16646447

ENST00000546361

149_289

917.0

Domain

CID

Tgene

CHERP

chr19:16772152

chr19:16646447

ENST00000546361

841_891

917.0

Domain

G-patch

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

135_143

300.0

Compositional bias

Note=His-rich

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

107_144

300.0

Topological domain

Cytoplasmic

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

166_178

300.0

Topological domain

Lumenal

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

200_209

300.0

Topological domain

Cytoplasmic

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

231_234

300.0

Topological domain

Lumenal

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

256_299

300.0

Topological domain

Cytoplasmic

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

40_51

300.0

Topological domain

Cytoplasmic

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

73_85

300.0

Topological domain

Lumenal

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

145_165

300.0

Transmembrane

Helical%3BName%3D4

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

179_199

300.0

Transmembrane

Helical%3BName%3D5

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

210_230

300.0

Transmembrane

Helical%3BName%3D6

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

235_255

300.0

Transmembrane

Helical%3BName%3D7

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

52_72

300.0

Transmembrane

Helical%3BName%3D2

Hgene

TMEM38A

chr19:16772152

chr19:16646447

ENST00000187762

86_106

300.0

Transmembrane

Helical%3BName%3D3

Tgene

CHERP

chr19:16772152

chr19:16646447

ENST00000546361

15_57

917.0

Repeat

SURP motif

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Fusion Gene Sequence for TMEM38A-CHERP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>92084_92084_1_TMEM38A-CHERP_TMEM38A_chr19_16772152_ENST00000187762_CHERP_chr19_16646447_ENST00000198939_length(transcript)=4063nt_BP=215nt
AGCTGCGGGGGCGCAGTCGCCGGGCCGCGGGCGGCGGGACGGACGAGGCCGGGGCCCCGGGTGGCACCCGGCAGGCGGGCAGGCGGGCGC
CATGGAGCTGCTCTCGGCGCTGAGCCTGGGCGAACTGGCGCTCAGCTTCTCGCGGGTGCCGCTCTTCCCCGTCTTCGACCTCAGTTACTT
CATCGTCTCCATCCTCTACCTCAAGTATGAGCCAGTCATCTGCAAGCAGCAGACCCCGGAGCTGGAGCCAGCCGCCACCATGCCACCCCT
GCCACAGCCCCCGCTGGCCCCCGCCGCGCCCATCCCGCCGGCCCAGGGCGCGCCATCCATGGACGAGCTCATCCAGCAGAGCCAGTGGAA
CCTCCAGCAGCAGGAGCAGCACTTGCTGGCGCTCAGACAGGAGCAAGTGACAGCGGCCGTGGCCCACGCGGTGGAGCAGCAGATGCAGAA
GCTTCTGGAGGAGACCCAGCTAGACATGAACGAGTTTGACAACCTCCTGCAGCCCATCATCGACACGTGCACCAAGGACGCCATCTCGGC
CGGGAAGAACTGGATGTTCAGCAATGCCAAGTCCCCGCCGCACTGTGAGCTGATGGCCGGCCACCTCCGGAACCGCATCACGGCTGATGG
GGCACACTTCGAGCTGCGGCTGCACCTCATCTACCTGATCAATGACGTGCTGCACCACTGGGCCCTGACGCGCGGAAAGTCTCTCCCTCA
CAGCCAGCGCAAGCAGGCCCGGGAGCTGCTGGCCGCCCTGCAGAAGGTCGTGGTGCCCATCTACTGCACCAGCTTCTTGGCCGTGGAGGA
AGACAAGCAGCAGAAGATCGCCCGGCTCCTGCAGCTCTGGGAGAAAAACGGCTACTTCGATGACTCCATCATTCAGCAGCTACAGAGCCC
AGCCCTGGGGCTTGGTCAGTACCAGGCCACCCTCATCAACGAGTACTCCTCAGTGGTCCAGCCGGTGCAGCTGGCCTTCCAGCAGCAGAT
CCAGACCCTCAAGACGCAGCACGAGGAGTTTGTCACCAGCCTGGCCCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCTCCAGAT
GCCGCAGATGGAGGCTGAAGTCAAGGCCACGCCTCCACCGCCTGCTCCACCCCCGGCCCCAGCACCTGCCCCTGCCATCCCGCCCACCAC
CCAGCCTGATGACAGCAAGCCTCCCATCCAGATGCCTGGCTCTTCAGAGTACGAAGCTCCAGGAGGGGTCCAGGATCCTGCAGCTGCCGG
CCCCCGGGGCCCCGGGCCACACGACCAGATCCCACCAAACAAGCCCCCTTGGTTTGACCAGCCTCACCCCGTGGCTCCTTGGGGCCAGCA
GCAGCCGCCAGAGCAGCCACCCTACCCGCACCACCAGGGCGGCCCACCCCACTGCCCCCCCTGGAACAACAGCCATGAGGGCATGTGGGG
CGAGCAGCGCGGTGACCCCGGCTGGAACGGCCAGCGCGACGCGCCCTGGAACAACCAGCCCGACGCCGCCTGGAACAGCCAGTTCGAGGG
CCCCTGGAACAGCCAGCACGAGCAGCCGCCCTGGGGCGGGGGCCAGCGCGAGCCACCCTTCCGCATGCAGCGGCCCCCACACTTCCGGGG
GCCCTTCCCGCCCCACCAGCAGCACCCGCAGTTCAACCAGCCTCCGCACCCCCACAACTTCAACCGCTTCCCGCCCCGCTTCATGCAGGA
CGACTTCCCGCCACGGCACCCCTTCGAGCGGCCGCCCTATCCCCACCGCTTCGACTACCCCCAGGGGGACTTCCCTGCCGAAATGGGGCC
CCCTCACCACCACCCTGGCCACCGCATGCCTCATCCTGGCATCAACGAGCACCCGCCTTGGGCTGGACCCCAGCACCCTGACTTCGGCCC
TCCCCCCCATGGCTTCAACGGGCAGCCCCCACACATGCGGCGACAGGGCCCACCCCACATCAACCACGATGACCCCAGCCTGGTCCCCAA
TGTGCCCTACTTCGATCTCCCTGCTGGGCTGATGGCCCCCCTCGTGAAGCTGGAAGATCACGAGTACAAGCCTTTGGACCCTAAAGACAT
CCGCCTCCCACCCCCCATGCCGCCCAGCGAGAGGCTGCTGGCTGCAGTGGAGGCCTTCTACAGCCCCCCGTCCCACGACAGGCCCAGGAA
CAGTGAAGGCTGGGAGCAGAACGGCCTCTATGAGTTCTTCCGAGCAAAAATGCGGGCCCGGCGGAGGAAAGGCCAGGAGAAGAGGAACAG
CGGACCCTCGAGGTCTCGGAGCAGATCCAAGAGTCGAGGGCGTTCTTCCTCCCGCTCCAACTCAAGATCCTCCAAGTCTTCAGGCTCGTA
CTCAAGGTCAAGGTCGCGCTCCTGCTCCCGTTCCTACTCCCGCTCCAGATCTAGAAGTCGGAGCAGGTCGCGCTCCTCCAGAAGCCGCTC
CCGGTCCCAGTCGCGGTCCCGGTCCAAGTCGTACTCCCCAGGAAGAAGACGCCGGTCACGGTCCAGGAGCCCCACCCCGCCTTCCTCTGC
TGGTCTGGGTTCTAATTCGGCGCCTCCCATCCCTGACTCAAGGCTCGGAGAAGAGAACAAAGGCCATCAGATGCTGGTGAAGATGGGCTG
GAGCGGCTCAGGCGGCCTCGGTGCGAAGGAGCAAGGGATCCAGGACCCCATCAAGGGCGGGGACGTCCGGGATAAGTGGGACCAGTATAA
AGGCGTGGGCGTGGCTCTGGATGACCCCTATGAGAACTACCGCAGGAACAAGAGCTACTCCTTCATCGCCCGCATGAAGGCCAGGGACGA
GTGTAAGTAGGCGCCCATGCCGGGAGCCGCGCCGGTGGCCAGCGGTGCCGGCTGTGGGACCTTCCTGGCTGACTGGCAGAGGAAGATTGC
AGTGACAGCTCAGTTCTTACACCGTCTCCACTTGTGGAGAGCCACAGGAAGAGAAGGAAGACCAGCGCATGCCCAGTGGGAACGCCGTGC
TCCATGGCGTGGAGGGCACGGGTGCCACCCACAAACCACACCAGGAGGCGCTGCAGCCACCAGGGCCCCAGGCTCGTTTTCCTTTATAGC
GAAGCAAAAAACACAAGACCCTCCGCCCGAGTAAATTCTTCAGCCACGAAGGGATGGATGTGCATCTGCCCTAAGTCAGATTGAAGCCTC
CTCCTAGGCTCCAGGAGGAGCATGTGCAGGAAGGGTTGGCCTGAGCCAGAGCCGGCACCCCAGCTCCTTCCTCCAGCTCCCCGCACCCAC
CGGCCCTGACCTGGCTTCCCCTCGGCTGTGTAGGGACAAAGCCGAAGCCCAGTGCCATGACTGCCCGCGGATTGAAAAACAGAAACACAA
AACTTTGACTTGACTTGCGAAGTGAAGCAGGGTTTTCATTTTTACTCTCCTTGGTTTAGGTCTAGAAAGAAGAATACTGACCTGAGAGGA
GGCCCAGTGAGATTCTGAAACCTAATTCTTCGAAGGCGTACTGGCCCTTAGTTCAGTTATTTTAGTTGTATAAGTTGATATTTTTTTTCT
GGAATGTAGCCATTTGCTGTTATCTGGGAAACAAGATTCTAACAGGAAACCAGCCTAAGACACTTCAGGTTGAGCGCTGCCTCGGAGTCT
GTGCCCGTCGCGTCCCCTGCTTGAGTTTTGCACTTGGAAGAACCCTGCACCGGCTGGCGTGTGCGACGGCCCAGTCCCATCCAGAGCATG
GAGCCCGACCCCAGCCAGCGCCTTCCACTCCATCATTTCATTTCACACCCCCGAAGGGAGGGGAGGCCAGGAGGGGAGCTGCTCCTGCCA
GAAGCTGGTGGGTGACCGTTGGGAATCGGCCACACCTGGTGTCCATGGGCAGCCTGGTGCAATTCCATTCATTTGTACAGAAACATTTTT
GAAAAATTCTTTTCAATAAGATGCAAAATCTTCCAACTTTTCAACCCAACGTGATGAATATTTGATTTTGTTCTAGATTTCCTGTAGCTG
TGAATTGTTAAAATGTATGATTCAGGATAAAACGTAAACACGTGCTGTTAGTAATTTCTTGTGGATTTCATTGTTTTGCCTTCAAATAAA

>92084_92084_1_TMEM38A-CHERP_TMEM38A_chr19_16772152_ENST00000187762_CHERP_chr19_16646447_ENST00000198939_length(amino acids)=902AA_BP=40
MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPVICKQQTPELEPAATMPPLPQPPLAPAAPIPPAQGAPSMDELIQQSQWN
LQQQEQHLLALRQEQVTAAVAHAVEQQMQKLLEETQLDMNEFDNLLQPIIDTCTKDAISAGKNWMFSNAKSPPHCELMAGHLRNRITADG
AHFELRLHLIYLINDVLHHWALTRGKSLPHSQRKQARELLAALQKVVVPIYCTSFLAVEEDKQQKIARLLQLWEKNGYFDDSIIQQLQSP
ALGLGQYQATLINEYSSVVQPVQLAFQQQIQTLKTQHEEFVTSLAQQQQQQQQQQQQLQMPQMEAEVKATPPPPAPPPAPAPAPAIPPTT
QPDDSKPPIQMPGSSEYEAPGGVQDPAAAGPRGPGPHDQIPPNKPPWFDQPHPVAPWGQQQPPEQPPYPHHQGGPPHCPPWNNSHEGMWG
EQRGDPGWNGQRDAPWNNQPDAAWNSQFEGPWNSQHEQPPWGGGQREPPFRMQRPPHFRGPFPPHQQHPQFNQPPHPHNFNRFPPRFMQD
DFPPRHPFERPPYPHRFDYPQGDFPAEMGPPHHHPGHRMPHPGINEHPPWAGPQHPDFGPPPHGFNGQPPHMRRQGPPHINHDDPSLVPN
VPYFDLPAGLMAPLVKLEDHEYKPLDPKDIRLPPPMPPSERLLAAVEAFYSPPSHDRPRNSEGWEQNGLYEFFRAKMRARRRKGQEKRNS
GPSRSRSRSKSRGRSSSRSNSRSSKSSGSYSRSRSRSCSRSYSRSRSRSRSRSRSSRSRSRSQSRSRSKSYSPGRRRRSRSRSPTPPSSA
GLGSNSAPPIPDSRLGEENKGHQMLVKMGWSGSGGLGAKEQGIQDPIKGGDVRDKWDQYKGVGVALDDPYENYRRNKSYSFIARMKARDE

--------------------------------------------------------------
>92084_92084_2_TMEM38A-CHERP_TMEM38A_chr19_16772152_ENST00000187762_CHERP_chr19_16646447_ENST00000546361_length(transcript)=4037nt_BP=215nt
AGCTGCGGGGGCGCAGTCGCCGGGCCGCGGGCGGCGGGACGGACGAGGCCGGGGCCCCGGGTGGCACCCGGCAGGCGGGCAGGCGGGCGC
CATGGAGCTGCTCTCGGCGCTGAGCCTGGGCGAACTGGCGCTCAGCTTCTCGCGGGTGCCGCTCTTCCCCGTCTTCGACCTCAGTTACTT
CATCGTCTCCATCCTCTACCTCAAGTATGAGCCAGTCATCTGCAAGCAGCAGACCCCGGAGCTGGAGCCAGCCGCCACCATGCCACCCCT
GCCACAGCCCCCGCTGGCCCCCGCCGCGCCCATCCCGCCGGCCCAGGGCGCGCCATCCATGGACGAGCTCATCCAGCAGAGCCAGTGGAA
CCTCCAGCAGCAGGAGCAGCACTTGCTGGCGCTCAGACAGGAGCAAGTGACAGCGGCCGTGGCCCACGCGGTGGAGCAGCAGATGCAGAA
GCTTCTGGAGGAGACCCAGCTAGACATGAACGAGTTTGACAACCTCCTGCAGCCCATCATCGACACGTGCACCAAGGACGCCATCTCGGC
CGGGAAGAACTGGATGTTCAGCAATGCCAAGTCCCCGCCGCACTGTGAGCTGATGGCCGGCCACCTCCGGAACCGCATCACGGCTGATGG
GGCACACTTCGAGCTGCGGCTGCACCTCATCTACCTGATCAATGACGTGCTGCACCACTGCCAGCGCAAGCAGGCCCGGGAGCTGCTGGC
CGCCCTGCAGAAGGTCGTGGTGCCCATCTACTGCACCAGCTTCTTGGCCGTGGAGGAAGACAAGCAGCAGAAGATCGCCCGGCTCCTGCA
GCTCTGGGAGAAAAACGGCTACTTCGATGACTCCATCATTCAGCAGCTACAGAGCCCAGCCCTGGGGCTTGGTCAGTACCAGGCCACCCT
CATCAACGAGTACTCCTCAGTGGTCCAGCCGGTGCAGCTGGCCTTCCAGCAGCAGATCCAGACCCTCAAGACGCAGCACGAGGAGTTTGT
CACCAGCCTGGCCCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCTCCAGATGCCGCAGATGGAGGCTGAAGTCAAGGCCACGCC
TCCACCGCCTGCTCCACCCCCGGCCCCAGCACCTGCCCCTGCCATCCCGCCCACCACCCAGCCTGATGACAGCAAGCCTCCCATCCAGAT
GCCTGGCTCTTCAGAGTACGAAGCTCCAGGAGGGGTCCAGGATCCTGCAGCTGCCGGCCCCCGGGGCCCCGGGCCACACGACCAGATCCC
ACCAAACAAGCCCCCTTGGTTTGACCAGCCTCACCCCGTGGCTCCTTGGGGCCAGCAGCAGCCGCCAGAGCAGCCACCCTACCCGCACCA
CCAGGGCGGCCCACCCCACTGCCCCCCCTGGAACAACAGCCATGAGGGCATGTGGGGCGAGCAGCGCGGTGACCCCGGCTGGAACGGCCA
GCGCGACGCGCCCTGGAACAACCAGCCCGACGCCGCCTGGAACAGCCAGTTCGAGGGCCCCTGGAACAGCCAGCACGAGCAGCCGCCCTG
GGGCGGGGGCCAGCGCGAGCCACCCTTCCGCATGCAGCGGCCCCCACACTTCCGGGGGCCCTTCCCGCCCCACCAGCAGCACCCGCAGTT
CAACCAGCCTCCGCACCCCCACAACTTCAACCGCTTCCCGCCCCGCTTCATGCAGGACGACTTCCCGCCACGGCACCCCTTCGAGCGGCC
GCCCTATCCCCACCGCTTCGACTACCCCCAGGGGGACTTCCCTGCCGAAATGGGGCCCCCTCACCACCACCCTGGCCACCGCATGCCTCA
TCCTGGCATCAACGAGCACCCGCCTTGGGCTGGACCCCAGCACCCTGACTTCGGCCCTCCCCCCCATGGCTTCAACGGGCAGCCCCCACA
CATGCGGCGACAGGGCCCACCCCACATCAACCACGATGACCCCAGCCTGGTCCCCAATGTGCCCTACTTCGATCTCCCTGCTGGGCTGAT
GGCCCCCCTCGTGAAGCTGGAAGATCACGAGTACAAGCCTTTGGACCCTAAAGACATCCGCCTCCCACCCCCCATGCCGCCCAGCGAGAG
GCTGCTGGCTGCAGTGGAGGCCTTCTACAGCCCCCCGTCCCACGACAGGCCCAGGAACAGTGAAGGCTGGGAGCAGAACGGCCTCTATGA
GTTCTTCCGAGCAAAAATGCGGGCCCGGCGGAGGAAAGGCCAGGAGAAGAGGAACAGCGGACCCTCGAGGTCTCGGAGCAGATCCAAGAG
TCGAGGGCGTTCTTCCTCCCGCTCCAACTCAAGATCCTCCAAGTCTTCAGGCTCGTACTCAAGGTCAAGGTCGCGCTCCTGCTCCCGTTC
CTACTCCCGCTCCAGATCTAGAAGTCGGAGCAGGTCGCGCTCCTCCAGAAGCCGCTCCCGGTCCCAGTCGCGGTCCCGGTCCAAGTCGTA
CTCCCCAGGAAGAAGACGCCGGTCACGGTCCAGGAGCCCCACCCCGCCTTCCTCTGCTGGTCTGGGTTCTAATTCGGCGCCTCCCATCCC
TGACTCAAGGCTCGGAGAAGAGAACAAAGGCCATCAGATGCTGGTGAAGATGGGCTGGAGCGGCTCAGGCGGCCTCGGTGCGAAGGAGCA
AGGGATCCAGGACCCCATCAAGGGCGGGGACGTCCGGGATAAGTGGGACCAGTATAAAGGCGTGGGCGTGGCTCTGGATGACCCCTATGA
GAACTACCGCAGGAACAAGAGCTACTCCTTCATCGCCCGCATGAAGGCCAGGGACGAGTGTAAGTAGGCGCCCATGCCGGGAGCCGCGCC
GGTGGCCAGCGGTGCCGGCTGTGGGACCTTCCTGGCTGACTGGCAGAGGAAGATTGCAGTGACAGCTCAGTTCTTACACCGTCTCCACTT
GTGGAGAGCCACAGGAAGAGAAGGAAGACCAGCGCATGCCCAGTGGGAACGCCGTGCTCCATGGCGTGGAGGGCACGGGTGCCACCCACA
AACCACACCAGGAGGCGCTGCAGCCACCAGGGCCCCAGGCTCGTTTTCCTTTATAGCGAAGCAAAAAACACAAGACCCTCCGCCCGAGTA
AATTCTTCAGCCACGAAGGGATGGATGTGCATCTGCCCTAAGTCAGATTGAAGCCTCCTCCTAGGCTCCAGGAGGAGCATGTGCAGGAAG
GGTTGGCCTGAGCCAGAGCCGGCACCCCAGCTCCTTCCTCCAGCTCCCCGCACCCACCGGCCCTGACCTGGCTTCCCCTCGGCTGTGTAG
GGACAAAGCCGAAGCCCAGTGCCATGACTGCCCGCGGATTGAAAAACAGAAACACAAAACTTTGACTTGACTTGCGAAGTGAAGCAGGGT
TTTCATTTTTACTCTCCTTGGTTTAGGTCTAGAAAGAAGAATACTGACCTGAGAGGAGGCCCAGTGAGATTCTGAAACCTAATTCTTCGA
AGGCGTACTGGCCCTTAGTTCAGTTATTTTAGTTGTATAAGTTGATATTTTTTTTCTGGAATGTAGCCATTTGCTGTTATCTGGGAAACA
AGATTCTAACAGGAAACCAGCCTAAGACACTTCAGGTTGAGCGCTGCCTCGGAGTCTGTGCCCGTCGCGTCCCCTGCTTGAGTTTTGCAC
TTGGAAGAACCCTGCACCGGCTGGCGTGTGCGACGGCCCAGTCCCATCCAGAGCATGGAGCCCGACCCCAGCCAGCGCCTTCCACTCCAT
CATTTCATTTCACACCCCCGAAGGGAGGGGAGGCCAGGAGGGGAGCTGCTCCTGCCAGAAGCTGGTGGGTGACCGTTGGGAATCGGCCAC
ACCTGGTGTCCATGGGCAGCCTGGTGCAATTCCATTCATTTGTACAGAAACATTTTTGAAAAATTCTTTTCAATAAGATGCAAAATCTTC
CAACTTTTCAACCCAACGTGATGAATATTTGATTTTGTTCTAGATTTCCTGTAGCTGTGAATTGTTAAAATGTATGATTCAGGATAAAAC

>92084_92084_2_TMEM38A-CHERP_TMEM38A_chr19_16772152_ENST00000187762_CHERP_chr19_16646447_ENST00000546361_length(amino acids)=891AA_BP=40
MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPVICKQQTPELEPAATMPPLPQPPLAPAAPIPPAQGAPSMDELIQQSQWN
LQQQEQHLLALRQEQVTAAVAHAVEQQMQKLLEETQLDMNEFDNLLQPIIDTCTKDAISAGKNWMFSNAKSPPHCELMAGHLRNRITADG
AHFELRLHLIYLINDVLHHCQRKQARELLAALQKVVVPIYCTSFLAVEEDKQQKIARLLQLWEKNGYFDDSIIQQLQSPALGLGQYQATL
INEYSSVVQPVQLAFQQQIQTLKTQHEEFVTSLAQQQQQQQQQQQQLQMPQMEAEVKATPPPPAPPPAPAPAPAIPPTTQPDDSKPPIQM
PGSSEYEAPGGVQDPAAAGPRGPGPHDQIPPNKPPWFDQPHPVAPWGQQQPPEQPPYPHHQGGPPHCPPWNNSHEGMWGEQRGDPGWNGQ
RDAPWNNQPDAAWNSQFEGPWNSQHEQPPWGGGQREPPFRMQRPPHFRGPFPPHQQHPQFNQPPHPHNFNRFPPRFMQDDFPPRHPFERP
PYPHRFDYPQGDFPAEMGPPHHHPGHRMPHPGINEHPPWAGPQHPDFGPPPHGFNGQPPHMRRQGPPHINHDDPSLVPNVPYFDLPAGLM
APLVKLEDHEYKPLDPKDIRLPPPMPPSERLLAAVEAFYSPPSHDRPRNSEGWEQNGLYEFFRAKMRARRRKGQEKRNSGPSRSRSRSKS
RGRSSSRSNSRSSKSSGSYSRSRSRSCSRSYSRSRSRSRSRSRSSRSRSRSQSRSRSKSYSPGRRRRSRSRSPTPPSSAGLGSNSAPPIP

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Top

Fusion Gene PPI Analysis for TMEM38A-CHERP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TMEM38A-CHERP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TMEM38A-CHERP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source