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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM38B-UBXN7 (FusionGDB2 ID:92094)

Fusion Gene Summary for TMEM38B-UBXN7

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM38B-UBXN7
Fusion gene ID: 92094
HgeneTgene
Gene symbol

TMEM38B

UBXN7

Gene ID

55151

26043

Gene nametransmembrane protein 38BUBX domain protein 7
SynonymsC9orf87|D4Ertd89e|OI14|TRIC-B|TRICB|bA219P18.1UBXD7
Cytomap

9q31.2

3q29

Type of geneprotein-codingprotein-coding
Descriptiontrimeric intracellular cation channel type BUBX domain-containing protein 7UBX domain containing 7
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000374692, ENST00000374688, 
ENST00000428095, ENST00000535858, 
ENST00000296328, 
Fusion gene scores* DoF score7 X 6 X 3=1268 X 8 X 4=256
# samples 78
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM38B [Title/Abstract] AND UBXN7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM38B(108457053)-UBXN7(196134264), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMEM38B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UBXN7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5799-01ATMEM38Bchr9

108457053

+UBXN7chr3

196134264

-


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Fusion Gene ORF analysis for TMEM38B-UBXN7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000374692ENST00000428095TMEM38Bchr9

108457053

+UBXN7chr3

196134264

-
5CDS-intronENST00000374692ENST00000535858TMEM38Bchr9

108457053

+UBXN7chr3

196134264

-
In-frameENST00000374692ENST00000296328TMEM38Bchr9

108457053

+UBXN7chr3

196134264

-
intron-3CDSENST00000374688ENST00000296328TMEM38Bchr9

108457053

+UBXN7chr3

196134264

-
intron-intronENST00000374688ENST00000428095TMEM38Bchr9

108457053

+UBXN7chr3

196134264

-
intron-intronENST00000374688ENST00000535858TMEM38Bchr9

108457053

+UBXN7chr3

196134264

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000374692TMEM38Bchr9108457053+ENST00000296328UBXN7chr3196134264-10649229871625512

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374692ENST00000296328TMEM38Bchr9108457053+UBXN7chr3196134264-0.0001581640.9998418

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Fusion Genomic Features for TMEM38B-UBXN7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM38B-UBXN7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:108457053/chr3:196134264)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+161_1937292.0Topological domainLumenal
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+1620_3337292.0TransmembraneHelical%3BName%3D1
TgeneUBXN7chr9:108457053chr3:196134264ENST00000296328011337_34224490.0Compositional biasNote=Poly-Glu
TgeneUBXN7chr9:108457053chr3:196134264ENST00000296328011285_30424490.0DomainNote=UIM
TgeneUBXN7chr9:108457053chr3:196134264ENST00000296328011408_48524490.0DomainUBX

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+16100_10437292.0Topological domainCytoplasmic
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+16122_13937292.0Topological domainLumenal
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+16157_17937292.0Topological domainCytoplasmic
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+16196_20737292.0Topological domainLumenal
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+16228_29137292.0Topological domainCytoplasmic
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+1634_5037292.0Topological domainCytoplasmic
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+1671_8237292.0Topological domainLumenal
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+16105_12137292.0TransmembraneHelical%3BName%3D4
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+16140_15637292.0TransmembraneHelical%3BName%3D5
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+16180_19537292.0TransmembraneHelical%3BName%3D6
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+16208_22737292.0TransmembraneHelical%3BName%3D7
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+1651_7037292.0TransmembraneHelical%3BName%3D2
HgeneTMEM38Bchr9:108457053chr3:196134264ENST00000374692+1683_9937292.0TransmembraneHelical%3BName%3D3
TgeneUBXN7chr9:108457053chr3:196134264ENST000002963280112_5424490.0DomainNote=UBA


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Fusion Gene Sequence for TMEM38B-UBXN7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92094_92094_1_TMEM38B-UBXN7_TMEM38B_chr9_108457053_ENST00000374692_UBXN7_chr3_196134264_ENST00000296328_length(transcript)=10649nt_BP=229nt
GCTGGAGCCGGCGCGGAGGAGCGGGCGGCCGCGGCTGTGCCCTCTCCTACTCCTCACCGCGCGAGCGCGGGGAACCAGTAGCCGCGGCTG
CTTCGGTTGCCGCGGTCGGTGGTCGTTATGGATTCTCCATGGGACGAGTTGGCTCTGGCCTTCTCCCGCACGTCCATGTTTCCCTTTTTT
GACATCGCGCACTATCTAGTGTCAGTGATGGCGGTGAAACGTCAGCCGGGTGCAAGTGAAAGTGTAGGAAAACATATGCTTGAAGCGTGC
AACAATAATCTGGAAATGGCAGTCACTATGTTTTTGGATGGTGGAGGAATCGCTGAAGAGCCCAGTACCAGTTCAGCAAGTGTCTCTACT
GTCAGACCACACACAGAAGAAGAAGTTCGTGCCCCAATTCCTCAAAAGCAGGAAATACTGGTGGAACCAGAACCATTATTTGGTGCTCCT
AAAAGACGACGGCCTGCACGTTCAATTTTTGATGGTTTCCGGGATTTTCAGACTGAAACTATTCGGCAAGAACAAGAATTAAGAAATGGA
GGAGCTATCGATAAGAAATTAACTACCCTTGCAGATCTATTCCGGCCACCCATTGATTTGATGCATAAAGGCAGCTTTGAAACAGCCAAA
GAGTGTGGCCAGATGCAAAATAAGTGGCTGATGATAAACATTCAAAATGTTCAAGACTTTGCATGTCAGTGCCTCAACCGCGATGTGTGG
AGCAACGAAGCTGTGAAGAATATTATCCGGGAACATTTCATTTTCTGGCAGGTTTATCATGACAGTGAGGAAGGTCAGAGATACATACAG
TTTTATAAGTTAGGGGATTTCCCCTATGTTTCCATATTGGACCCACGGACAGGTCAGAAGCTAGTAGAATGGCACCAGTTAGATGTATCT
TCTTTCTTGGACCAAGTGACGGGATTTCTGGGTGAACATGGACAACTGGATGGACTTTCTAGCAGTCCCCCCAAAAAATGTGCCCGTTCA
GAGAGCCTTATAGATGCAAGTGAAGACAGCCAGCTAGAAGCTGCCATCAGAGCCTCCTTACAAGAAACACATTTTGATTCAACACAGACA
AAACAGGATAGCCGCTCAGATGAAGAATCTGAATCTGAACTTTTTTCTGGCAGTGAGGAGTTCATATCCGTTTGTGGCTCTGATGAAGAA
GAAGAGGTAGAGAATCTTGCCAAGTCCAGAAAGTCTCCCCACAAAGATTTGGGGCATAGAAAAGAGGAGAATAGAAGGCCGCTGACTGAG
CCACCAGTCAGAACTGATCCTGGAACAGCCACAAACCACCAAGGATTGCCAGCTGTGGATTCAGAGATACTGGAGATGCCACCTGAAAAA
GCAGATGGAGTAGTGGAGGGGATAGATGTAAATGGACCAAAAGCACAGCTGATGTTGCGGTATCCAGATGGAAAAAGGGAACAGATCACT
CTTCCAGAGCAAGCTAAACTGCTAGCTTTGGTGAAGCACGTGCAGTCTAAAGGATACCCAAATGAACGTTTTGAACTTCTCACCAACTTT
CCTCGAAGGAAATTATCTCATCTGGACTATGATATTACATTGCAAGAGGCAGGCCTTTGTCCTCAAGAGACTGTCTTTGTACAGGAAAGA
AATTAACACCATGGCTTGACCTCTCTCAGCTTACCCCTTTTTTCCCTTTTCCTGTGAGATACATGTCACTAAGTATGCATTTTGGCTCAT
AGGACCACAGAGCCAAAGTTGGGCAAGCAAGTCACCTTCCTTCTCTTATTTCTTGATCTCTCCTATAATCAGTCTCTTTCTCCCCCTTTG
TTTCTTTCTCCTCTTCTGTTTTCTCGCTCCCCACTCCGTACCCTTCTGCCTCCCCCTCCCCCCACACTTTTCTTTCTTACCTAATCTGGT
GACCAAACTGAAGTGTAAGGATAAGACCTCTCCTAGTACTAGCAGCAGGAATTGTGTGTTCCAGTAAGTGGTCTCTTGCACGGCACTTTT
TTGGGATCAAATGTTAACGTTACTCCCCAGACTCTTCGGGCAAAGGAATGGCTAGATTCAGAGTAAGAACAACCCTCCCTTTTTTGTAAG
TCCCCGTGTTTAGCAGGGAGAAGAAATTCTCTAACATGGGTTTGGTTTTGTTGTGTTCTTCATGTGGAAATGTCGCTTAACAAAATATCC
AGGCTTTTGTTTACGTGGAAAAAGCATCCCTTGTAATGATTGCTCATCATACTTAAAAACCTTTTTCAAAGGATTTTCATGTTCCCAGCT
ATAAGGACTATTTCCATGACATGTGTTATTGGCAGAATGAGTGTTAAATATGGAGCATATAGCATGGGGTGACTTTCATTGTCCTAACCT
GAGACAGTTTTCCTTATTACTCTGTATTGATCCTGCTAGTCCAAGAATGGACATGAAGTGAACCTATCGTGGTGACTGGGATAGGAAGGT
GCTTGCTATTTTTGCCAGCACAGCATATTAGTTCCTTTGGAGCCCTCCATTGTCTGAGTCTGCAGTGATCTGTAGGAAGGCAGCTGGTCA
ATAATCATGTAGTACAATGGCTTGGAATTGTAACCACTATGGTTATTGATTGTCCTGTGTTGTTTCAGGCATACTTAGGTATGTCCCTGG
GGAAAAAGAAAACCATTCAGCTGAGAGTTGCTAACCATGTTCTTTTGGTTAGAAATAATGGTTCATTTTTTGCCCCTGGTTGGAATAGTC
TCTAAAAGGCTCTGGTGACTGAATTGAACATGAGTCCGCATGCTGTTTTCTTTCAAAAGGTATCAAAACGGAAAGCCTCTCTAAGGGGAA
GACCTTTCAACTCCATTCAGAAGACAACATTTAGTAAGGAGGATGGCGGAGGTTACTAGTAATTTTCAGATGTCTTGGGCTTTTTCTGCC
AACAAAACCCAAAATCAAATTAGAGTTGGTGAAAGCTTTCTTCAGTGTTTTTAGAAGAGGCCATCTTGAATCTGTAGAATACCATTTACA
CATCAACTTCACCCTATGCTCATTTCGTATTTTGAGCTTAAATGGAGTCCTCTGAAGGGGGGGTAGTCGTGATTCTGGTGGCAAAACTAG
AACTTTTAACTTGTAAAATGAAAAATATTAAATGGACCTTTTTGTCAGTTGAGGATTTAGATTGATTCTTTTATCTGAGGAGCGTATGTT
CCTCAGATGTTGCGTAGAGACCTTTAGGTTTTCATCTACTTTAAGATTGCTCTCTTGGCAATTAGGGGATTTGGGAAAAGAAGAAAAAAA
GATGCCATGTGTTGCTAGTACACAGTTATAGGATATGGTTTCTAATGGTTGAATTTTGAGGAACTCTCCCTAAAGAATGAGTTTTATATC
TCCTCAAGGAAATCATGGAAAAATCTGTTTATTCTTCAGTGAGTCCTTTTGAATTAATGTTCTTAAATTTTTTTCTAAGTCTGTGTAAGT
GCTTATGTATAAGTATATAATTGTATAAATATTTATAAATATATTTATATAATTACGGTTTCATTTCTACCTTGAGTCAAAGTTCTGTCT
TTAGATTGGTGACTGAGTAATACTTACACTTTGGTGTTTTTTCTTAGGTTCTTGAGGCTTACTTAACTAGCAGCTTCTGATTTATTGAGT
GAAAGATGGTTTTCATGTTAATTCCTCAGTTGCATCTCTGAACTTGGATAACATACTTGCCGTTTGAAAAATAGAGCTGTATACTGTCAA
AGGTGCACTGGAGGGTAAAACATTTGTTGGTAGTAGACAAGCTCAGAAATCCAAAAATTCAGGGAGGGCACAGGGTAAGAAGAGAGGTTT
GCTCAGCTTTGTGCTCTGATGGCACCCATCTGTACTCCAGCAAAGTCATAGCTGAAGCCCAAATCGCTCAAACGTGTGAAGTCAATCATT
TTTCCTATAGGGCTCTGTTTCCTTTTCTTTACCTTCTAGCTTCTCTTGATAAAACAGTTGGGAGAACTGCCAACGTGTTCATCAGTGAGA
GGGTGTGGTTCTTTCCGATATGTTCAGCACGTGCATATTCATTTATGAGAAACCAAAGTAACTTCTTCAACTCGGGTTACTGTGGGATGA
TTAAGTAGATATAAAGTGATTTAAAAGACAGCATGGTACTTTCACTCAGCTTAACATGCAGCTGGGATGTCTACAATACAAGATGTGGTG
GGTTTTATTTTATTTTATTTTGAGGCAGGAGTGTAATTATCTTAGGGTTGATATAAAGGCCCATGGGAAGAGTTACGGATTGTACATGGG
AAGAATCCATAAGGAGTATTGCCTTGCTCAAGAATTTAATCCGCTGACAGTATGCTTCTTCCAGTTTGCCTTACTTCCTCTGCAAGTTTC
TTTGCTCCTTAGGGCAGAGGTTTTATTGAATAGATTAAATGAGGTCAGTAAGATTAGTTAAAAATAGTCATTCCTTGTGGGTGTTGGACA
CAGCTTGAAAGGAGTGTTTAAAAAAAAAAAGCTAGGGAGGAAAAGAACAAGAAAGATAGACTTCGAGAGTGATAAGAGAAAAATACAGGG
AGATGGAATGGAAACTACCAGGAAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCGGAGGTGGGCAGATCACCT
AAGGTCAGGAGATCGAGGCCAGCCTGAGCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTACCTGGGTGTGGTGGCGTGCA
CCTGTAATCCCAGCTACTCAGAGGCTGAGGCAGGGGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATCGCACCATTAC
ACTCCAGCCTGGGCGACAAAGCGACACTCCATCTCAAATTTAAAAAAAAAAAAGAAGAAGAAGAAGAAAACTAGTGGGAAAAAAGTGAGA
GGAATACTTTTTTGAAATTGGTATCGGAAGGAACTGGAGAAGAGAAAACAACAGTGCCAAATGAGAAAAGAACAGGAAACTTAATACTAA
TTGGCATGCACCAGATACTTTTGTGTACATTTGCCTCTTCAATCTCCCGAAGAATCGTACAAAATGTATACTTTCTTCCCATGTTAAGAA
AACAGGTATAGAGAACTTATTCAGGACTCATAGCTAGTGAGTGGCAAATCAGAATTGGAATCCAGAGTCCATGCTGTGGTCTCCTTCAGC
AAGAGAATCAAGCTACCCAGATGATTCTCTTCTCATTGTTTGGCTTTGTAAAGTGTCACTTAGTTTTGTTCCCATAAATATAGAGGAAGT
AGTTGGGTTAAAGTTGTGGGATTTGCACTATGCCTATACATTTTTATTTATGCCATTATTTTGAGAGGCTGATTATTGCTTTTTTAAAAT
GATGCACTGGTGAAGATGTGAAAGTAAAATTGCCACGTGGCATTATTTGCCAAGAATAAATGAAAAGGGTAAAAAAACAATTTTTTCTTT
TTTTAAACATTTTTCAGAAAAGATACAATTACCTTTTTTAATAGGTGAGCGCCACCACGCCCGGCTAATTTTTGCATTTTTAGTAGAGAC
AGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCTTGATCTCGTGTTCCGCCCACCTCGGCCTCCTAAAGTGCTGGGATTACAGGCA
TGAGCCACTGCGCCCGATCTACAATTCTGTTTTCTGTGTCCCATCCATACCAGATTATTGAACCCTCTGTGTGTATGTTTTTAAATCTTG
TATATAATTCTACTTCCTTGACTTACAAGTCAACAATTAGCTATTGAGTTCTTTATAGAAGTTGGAAGTATTTTGAAATCTGAGATCTAA
TTCCTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAATATTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTTGGGAGTTCGAGAT
CAGCCTGGCCAACATGGTGAAACCCCATCTCTACTGAAAAATACAAAAATTAGCCAGGCATGGTGGCTGTCTGTAATCCCAGCTAATGGG
GAGGCTGAGGCACAAGAATCTCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCACACCACTGCACTCCATCCTGGGCAATGGA
GCGAGACTCTGTCTCAAAAAATAATAAATAAGATATGATTCCTGCCTGTTTTATCCAGTTAGAGAGACACACTACACATGAAATAATTGG
AGAGCATGTAAATGTTTACCTATTAGTTCAAACTTAGAAAAAGGGAAGAATATGTTTTAGTTAGCAAAGTCTTAAACAAGACTGAAGTGG
CAAGCACTGTAGCTCACGTTTTCTTTTGACTCACCTTTTTCTTTAGCTCCACCTTTTGTAACTTCTAGATTTGGGGCATGAAGTTCTGCC
ACTAAGGCATAACCAGTACCCAAGTAGGAAAGGATTATTGATCCCTGGAGTAAAGATTCCTAGCTTGCGGGGATCTCACTATTGATCCCC
CGGAGTAAAGATTCCTAGCTCGCAGGAATCTTACTTGCACACTTAGGGAAAATACCAGAGGGAGCCACTAGCAACCGAAAAATGAAGGAA
AGATTTAATTTCTCTACCCAGGTACAAATCCAATGCATAGTATAGTATATGTTATATGCAGAAAGGGCACTGGAGGTGTGAGAGCCCTTT
GGGTAACAGCTCTGCTAGTTGTTACCTTCACACTTCTCTTTCTTCTTAATCTCTGGTTTCTCGTCTGAAAAATGAGATAATTGGACTAGA
TTAATAGTTCTCAGCCTTTTCTAGAACAACAAATTAGATTATCTCTGAAGTCCTTTTCCAAAATTTCATGCTTCCAGTCTCTCCCCGTGA
TTGCGTATTATCCCTAGGCTAATTAAAAGTGTGCTGGTTAATCAGTTTCTTTACTTTTTTTTTCTCTCTTTTTTTTATTCTGTGTTCAGG
TATCATTTGACCAACAACTTGCTCTTAATCTTACTGCGATGACTGAAATCTCCAAAGAGGAGAGTATAGTAGTTATAGGTCTAGTAATAA
TAATCTTGTAAACAATTCATTATTTTTTAAAACTTAATGCTGTGTGCCTAATCAGTGTTGAGTATGACTAAAATGTAAATGAGAACCAAA
TATGACACTAACGCTGGCACTAAATTTTATTTTTACTTGTGTACTTAAAGTACTTTACTGGCCTGTTGGGAAATTGATTTGTATAAGATT
CACACCTGGTTTTGGCAGAAACAGCTTTTTAAAGATACAATTAGGCTGACTTAAAAATGTTTTTTATTCCACAGAATGTATCTTTATTAT
GTCATTCTTACCGTCTCTCTGCCTTTTTTGACCATCATGTAACTACGCAGTAGTAAATCATGGGGTGCAGGCTGATGAATTAGTAGTCTT
TGTAAAACTAAAATGTAATGAGCATAGGAAGAGACAGCTCTTCTGGTGAACATGGCAGTTTTCCGGTAATACCAGCCTTGATGAATAGGC
TAAAGACAGCTGTGTACTATGGACATTCAACTTCACTGGATTGCCTGGCTTAGCTTTTCAGTTATTGTCTTGCCGTGAAACATGGTGTTG
CACTGTACACATTTTAGAATAGTGGCAAGAATGTTCTTTAGAACTGCAGATAACCCAACAGAGAATACCATACCAATATATCGGTTTCTC
CTGTTACATAGAGATTTGGTATTTCAGTGATGGTTATGGTTTTTGACTCACCTGTGTGTCAGTCCTGCTAGAGAGACAGTATAGAATCAA
GAATTTCTTGATGTCTTTTTAAAAATAGAGATTATAATGGCCTTGCTAGTTGTCCTGTGAAGTGACAGACCCTTAATTAGAAATCTTTTA
ATCCTGCTTTCCATTTTACTTCTCCACCATTTATTTTTAACATTCATTCTCTGAAAATAGTTATGATTTTTAGTGTAATTGGCTATGTTT
AAGAAATTCCATTTCAAAGTCTTAATATGTAACAATCTTCATTTTTTATAAAATTGAAGGACATTTTTGAGGCAAACTTACTTTTATAGC
TCATTTTCTCCCTAGTTAAGGAGAATTCTCTGGTTTCATATAGAGAATGGCTAGCTCTGTGATACCCCACCCTCTTTGTGGCCTACCAGT
TGCTGTTGTGTTGCTTAAAATTGCAGATATTCTCATAAACATGATGATTTTTGGCACAGGCCTTTCTTTGCTATTGATTTCAAAATAAAG
TTGGGCAATCCAATTTGAACTACTTTAATAAACATAATTTAGCATTCCTGTAATGAGAAAGTATTTTCAAAAGATAACCAGATTTATTTC
TAGGATTAGAGATGGCAAATACCAATGATAGTATTTTTCCCAAGAGCAATCACAGATTAATCTATAAATATGAGAAGTCGCATTATTGTA
CTTAATTCTTTGGCAACAAACAGCAAGTTTTTATTGTTTAATTGTATTTCCTCTCTAGAGATCACAATACTCTGGGTATTTTATATCCCT
TCTAAAGGTCATTTGGGTTTTCAAATGGGAAGAATAGTCAAGCTAAGCTGGACTAAACCTAAGTAATATTTTTTCTCATCAAAAGAAGTT
ATTAATCTAACTGGGTTAGCATGAGTCATTCATTTTTTAGACATGATAAATGGGAAACATATCAAATCATTAGATAAATTCTGACCTGGA
ATTGAATTCCCCCTTTCTTAAAATCTTTTTAATTTGCTTTTTTCATAGACTCAGTATGGAACTCTTAACTGATAAGGGAGAGATTCTTGA
TCTGGAACCGTTCCCTGCCATTCTCCTTTTTTCTCTCTATCTAGGTAGCTGGTTCCATAGTGCCCGTCACGAGGGTCCATTTCAGTTTGA
TGACATTAGACTGCTTACACTCAGCTGGATGCCTTGCTGTTTGCAGCAACATGATTTTACAGTATGCTTTTCTCAAAGCTTTGCATTCTT
AATGGAGATATCAAATGGTGTAATTCCAAATATAAATATGTTTATGACACTAATCATATGCTTTTAACAATAACTTTTTGATAACTTATT
GCCCTGTAAGTTAAACCTTACACGGAGTGACTGTTGCCATCAGAAAATCCCCTTTCACCTGCTAGAGAGAGTGAAAGTAGTGCGTGGCCT
CCACTTTTCAGTTAACGAGTAGCAAGCTTCTAGTAGGGGCTGCTTATCTGACCCATGTGGGGTCTTGGGCCTTGTTACTTTCCTGGGTTC
GTCCCTTCAGCTGGAAAGGCTGTTGAAAACACTTGCCAGGAAACAGTAAAGCTGTGAGAGAATCTTCTAGTCTTAGATATAGAGAAATGA
GTACCAGTTGATGCTAACACGATACTTAGACTTTGAGGGGCTTCCATCCAAGCTTTGGCATGAATCTGTTAGACACGGTTTTCTTCACTC
CTCTGATAATCTTTTTTTCCAGAATGGTTTTTTGTTGTTGTTGTTGTTAACAAATTCTAAACATCCAGTGTTACTTTTTGTTTTGTTTGT
TTTGTTTTGTTTTGTTTTGTTTTGTTTGCCCTTCAGGAAAGTCCTTTTTCGAGTAGGTATTGATTGTTCCCTGGAAACTCTCAGCAGTGT
CTGTGCAGGCTCTGTGCATGCTTTGTATGAGTTCGGCTTGAACAATGCATTTGAAGTCACCTGGGATGTCCAGTTCTGGCATGTCTTCAT
TGATTGTGTTTTTAAACATGTTTCATGTTTCATGTCATTTTCCAAACCTCACTTTACATCTTACTCAGAGAAGTTAATCAAGGAATGAAA
TTTCTAGGGGGATAGGGATGATGAGGGTGGGTTGGGGGCTTGAGTGAAGTCAACTTGGGGTATTTGCTTTAAAGTGTTTTCTAAAGCAGT
TCCTAACAGTATTTAGAGATTCCCTGGGATGTTTGTGGCTCAACTTATTCTGGACAAAGTGTGTGTGGGGGTGGTCTTACTGAGATTTGC
ATTCTTAATGCAGGACAGGCTCTAAATTTCATCTGTACTCTAAATTTGTGATTGAATCCAAGAAGATAACAGAGACAGTGCTCCTGTTGT
AATGTTTCTGGCAAGTGCTCCCTAAAATGCACATCGAATTCTGTTTTCTGGGCCTTTTCTCCAATGGTGCTAGGAGATACCGTTGATTTC
TGCAGCTCTTCTCAGTGGTGGGAAGAAGTCTTTGGGATTGTTGAGCAAGGGGCAGCTGGACCATCCACTAAATTTTTTTGTTCAAGACAC
ATTAGAGACCCTCCTGTATATCTAGTAAGTCATAATAAAGGTGCTTGGGAAAGCCTTAAATTTGAAGACACATGGAGGCGGTAGAAAATT
AAACTTGTAAGAGGAGAAAAACATGCCATTAGGTAACGCAGAGTTGTAACTACTGGCTAAGACTCAATGGAACTTCCACTTGCTCTAAAA
CCAGGGAAATCTTAGATAACTGGGTGTGATCTACCTATAGATCTACCTAGTCTATAGGTAATAATTTCCAGAAGGAGGATCTTGCTGTCA
GTTGGGGATCCTCTGGTTTGGTCTGTACCAAATTGTGAATACTCTTGCTGTGTTGTACCCAGTTGCTTTATATTAATACTGCAACTTGAA
ACGGGGAGGGTGGGGGGACAATGGGGTGGGGGAGGGAAGGGAGTGGGACGATAAGTCTTTTGAAGACATCAGCTCACTGTGCTGAGAGAG
GGACCAAACTCAAGGAAACCTCTGATCTATACATTCAACTGCTGCATTTTTTTATAAATACATGTAAATGTCCTGTTGTAATATTTGATC

>92094_92094_1_TMEM38B-UBXN7_TMEM38B_chr9_108457053_ENST00000374692_UBXN7_chr3_196134264_ENST00000296328_length(amino acids)=512AA_BP=47
MLRLPRSVVVMDSPWDELALAFSRTSMFPFFDIAHYLVSVMAVKRQPGASESVGKHMLEACNNNLEMAVTMFLDGGGIAEEPSTSSASVS
TVRPHTEEEVRAPIPQKQEILVEPEPLFGAPKRRRPARSIFDGFRDFQTETIRQEQELRNGGAIDKKLTTLADLFRPPIDLMHKGSFETA
KECGQMQNKWLMINIQNVQDFACQCLNRDVWSNEAVKNIIREHFIFWQVYHDSEEGQRYIQFYKLGDFPYVSILDPRTGQKLVEWHQLDV
SSFLDQVTGFLGEHGQLDGLSSSPPKKCARSESLIDASEDSQLEAAIRASLQETHFDSTQTKQDSRSDEESESELFSGSEEFISVCGSDE
EEEVENLAKSRKSPHKDLGHRKEENRRPLTEPPVRTDPGTATNHQGLPAVDSEILEMPPEKADGVVEGIDVNGPKAQLMLRYPDGKREQI

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Fusion Gene PPI Analysis for TMEM38B-UBXN7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM38B-UBXN7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM38B-UBXN7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource