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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM45A-CMSS1 (FusionGDB2 ID:92120)

Fusion Gene Summary for TMEM45A-CMSS1

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM45A-CMSS1
Fusion gene ID: 92120
HgeneTgene
Gene symbol

TMEM45A

CMSS1

Gene ID

55076

84319

Gene nametransmembrane protein 45Acms1 ribosomal small subunit homolog
SynonymsDERP7|DNAPTP4C3orf26
Cytomap

3q12.2

3q12.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 45ADNA polymerase-transactivated protein 4dermal papilla derived protein 7protein CMSS1
Modification date2020031320200313
UniProtAcc.

Q9BQ75

Ensembl transtripts involved in fusion geneENST00000462884, ENST00000403410, 
ENST00000323523, 		ENST00000421999, 
ENST00000489081, ENST00000496116, 
Fusion gene scores* DoF score5 X 6 X 3=9011 X 9 X 9=891
# samples 613
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/891*10)=-2.77691380849347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM45A [Title/Abstract] AND CMSS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM45A(100238452)-CMSS1(99879274), # samples:1
TMEM45A(100238452)-CMSS1(99865817), # samples:1
TMEM45A(100211772)-CMSS1(99879274), # samples:1
TMEM45A(100211771)-CMSS1(99879273), # samples:1
TMEM45A(100238451)-CMSS1(99879273), # samples:1
Anticipated loss of major functional domain due to fusion event.TMEM45A-CMSS1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMEM45A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CMSS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A5ZV-01ATMEM45Achr3

100211771

+CMSS1chr3

99879273

+
ChimerDB4BRCATCGA-A7-A5ZV-01ATMEM45Achr3

100211772

+CMSS1chr3

99879274

+
ChimerDB4BRCATCGA-A7-A5ZV-01ATMEM45Achr3

100238451

+CMSS1chr3

99879273

+
ChimerDB4BRCATCGA-A7-A5ZV-01ATMEM45Achr3

100238452

+CMSS1chr3

99879274

+
ChimerDB4LUSCTCGA-66-2758-01ATMEM45Achr3

100238452

+CMSS1chr3

99865817

+


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Fusion Gene ORF analysis for TMEM45A-CMSS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000462884ENST00000421999TMEM45Achr3

100238451

+CMSS1chr3

99879273

+
3UTR-3CDSENST00000462884ENST00000421999TMEM45Achr3

100238452

+CMSS1chr3

99879274

+
3UTR-3CDSENST00000462884ENST00000421999TMEM45Achr3

100238452

+CMSS1chr3

99865817

+
3UTR-intronENST00000462884ENST00000489081TMEM45Achr3

100238451

+CMSS1chr3

99879273

+
3UTR-intronENST00000462884ENST00000489081TMEM45Achr3

100238452

+CMSS1chr3

99879274

+
3UTR-intronENST00000462884ENST00000489081TMEM45Achr3

100238452

+CMSS1chr3

99865817

+
3UTR-intronENST00000462884ENST00000496116TMEM45Achr3

100238451

+CMSS1chr3

99879273

+
3UTR-intronENST00000462884ENST00000496116TMEM45Achr3

100238452

+CMSS1chr3

99879274

+
3UTR-intronENST00000462884ENST00000496116TMEM45Achr3

100238452

+CMSS1chr3

99865817

+
5CDS-intronENST00000403410ENST00000489081TMEM45Achr3

100238451

+CMSS1chr3

99879273

+
5CDS-intronENST00000403410ENST00000489081TMEM45Achr3

100238452

+CMSS1chr3

99879274

+
5CDS-intronENST00000403410ENST00000489081TMEM45Achr3

100238452

+CMSS1chr3

99865817

+
5CDS-intronENST00000403410ENST00000496116TMEM45Achr3

100238451

+CMSS1chr3

99879273

+
5CDS-intronENST00000403410ENST00000496116TMEM45Achr3

100238452

+CMSS1chr3

99879274

+
5CDS-intronENST00000403410ENST00000496116TMEM45Achr3

100238452

+CMSS1chr3

99865817

+
5UTR-3CDSENST00000323523ENST00000421999TMEM45Achr3

100211771

+CMSS1chr3

99879273

+
5UTR-3CDSENST00000323523ENST00000421999TMEM45Achr3

100211772

+CMSS1chr3

99879274

+
5UTR-3CDSENST00000403410ENST00000421999TMEM45Achr3

100211771

+CMSS1chr3

99879273

+
5UTR-3CDSENST00000403410ENST00000421999TMEM45Achr3

100211772

+CMSS1chr3

99879274

+
5UTR-intronENST00000323523ENST00000489081TMEM45Achr3

100211771

+CMSS1chr3

99879273

+
5UTR-intronENST00000323523ENST00000489081TMEM45Achr3

100211772

+CMSS1chr3

99879274

+
5UTR-intronENST00000323523ENST00000496116TMEM45Achr3

100211771

+CMSS1chr3

99879273

+
5UTR-intronENST00000323523ENST00000496116TMEM45Achr3

100211772

+CMSS1chr3

99879274

+
5UTR-intronENST00000403410ENST00000489081TMEM45Achr3

100211771

+CMSS1chr3

99879273

+
5UTR-intronENST00000403410ENST00000489081TMEM45Achr3

100211772

+CMSS1chr3

99879274

+
5UTR-intronENST00000403410ENST00000496116TMEM45Achr3

100211771

+CMSS1chr3

99879273

+
5UTR-intronENST00000403410ENST00000496116TMEM45Achr3

100211772

+CMSS1chr3

99879274

+
Frame-shiftENST00000403410ENST00000421999TMEM45Achr3

100238452

+CMSS1chr3

99865817

+
In-frameENST00000403410ENST00000421999TMEM45Achr3

100238451

+CMSS1chr3

99879273

+
In-frameENST00000403410ENST00000421999TMEM45Achr3

100238452

+CMSS1chr3

99879274

+
intron-3CDSENST00000323523ENST00000421999TMEM45Achr3

100238451

+CMSS1chr3

99879273

+
intron-3CDSENST00000323523ENST00000421999TMEM45Achr3

100238452

+CMSS1chr3

99879274

+
intron-3CDSENST00000323523ENST00000421999TMEM45Achr3

100238452

+CMSS1chr3

99865817

+
intron-3CDSENST00000462884ENST00000421999TMEM45Achr3

100211771

+CMSS1chr3

99879273

+
intron-3CDSENST00000462884ENST00000421999TMEM45Achr3

100211772

+CMSS1chr3

99879274

+
intron-intronENST00000323523ENST00000489081TMEM45Achr3

100238451

+CMSS1chr3

99879273

+
intron-intronENST00000323523ENST00000489081TMEM45Achr3

100238452

+CMSS1chr3

99879274

+
intron-intronENST00000323523ENST00000489081TMEM45Achr3

100238452

+CMSS1chr3

99865817

+
intron-intronENST00000323523ENST00000496116TMEM45Achr3

100238451

+CMSS1chr3

99879273

+
intron-intronENST00000323523ENST00000496116TMEM45Achr3

100238452

+CMSS1chr3

99879274

+
intron-intronENST00000323523ENST00000496116TMEM45Achr3

100238452

+CMSS1chr3

99865817

+
intron-intronENST00000462884ENST00000489081TMEM45Achr3

100211771

+CMSS1chr3

99879273

+
intron-intronENST00000462884ENST00000489081TMEM45Achr3

100211772

+CMSS1chr3

99879274

+
intron-intronENST00000462884ENST00000496116TMEM45Achr3

100211771

+CMSS1chr3

99879273

+
intron-intronENST00000462884ENST00000496116TMEM45Achr3

100211772

+CMSS1chr3

99879274

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000403410TMEM45Achr3100238452+ENST00000421999CMSS1chr399879274+15676655601351263
ENST00000403410TMEM45Achr3100238451+ENST00000421999CMSS1chr399879273+15676655601351263

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000403410ENST00000421999TMEM45Achr3100238452+CMSS1chr399879274+0.0082358070.9917641
ENST00000403410ENST00000421999TMEM45Achr3100238451+CMSS1chr399879273+0.0082358070.9917641

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Fusion Genomic Features for TMEM45A-CMSS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMEM45Achr3100211772+CMSS1chr399879273+0.97684250.023157466
TMEM45Achr3100238452+CMSS1chr399879273+0.002939520.9970605
TMEM45Achr3100238452+CMSS1chr399865816+4.90E-081
TMEM45Achr3100211772+CMSS1chr399879273+0.97684250.023157466
TMEM45Achr3100238452+CMSS1chr399879273+0.002939520.9970605
TMEM45Achr3100238452+CMSS1chr399865816+4.90E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TMEM45A-CMSS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:100238452/chr3:99879274)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CMSS1

Q9BQ75

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM45Achr3:100238451chr3:99879273ENST00000323523+16100_1200276.0TransmembraneHelical
HgeneTMEM45Achr3:100238451chr3:99879273ENST00000323523+16150_1700276.0TransmembraneHelical
HgeneTMEM45Achr3:100238451chr3:99879273ENST00000323523+16218_2380276.0TransmembraneHelical
HgeneTMEM45Achr3:100238451chr3:99879273ENST00000323523+1651_710276.0TransmembraneHelical
HgeneTMEM45Achr3:100238451chr3:99879273ENST00000323523+167_270276.0TransmembraneHelical
HgeneTMEM45Achr3:100238452chr3:99879274ENST00000323523+16100_1200276.0TransmembraneHelical
HgeneTMEM45Achr3:100238452chr3:99879274ENST00000323523+16150_1700276.0TransmembraneHelical
HgeneTMEM45Achr3:100238452chr3:99879274ENST00000323523+16218_2380276.0TransmembraneHelical
HgeneTMEM45Achr3:100238452chr3:99879274ENST00000323523+1651_710276.0TransmembraneHelical
HgeneTMEM45Achr3:100238452chr3:99879274ENST00000323523+167_270276.0TransmembraneHelical


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Fusion Gene Sequence for TMEM45A-CMSS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92120_92120_1_TMEM45A-CMSS1_TMEM45A_chr3_100238451_ENST00000403410_CMSS1_chr3_99879273_ENST00000421999_length(transcript)=1567nt_BP=665nt
GCGGGCCGACGTCAGCCGAGCACGTCCCCCACGTCCTCTCCTTCTCGCCACTTATTATTTATTCGTTTTCCCAAAGAAGCGACTAGGGAC
CCAAGTTTAAAAATTCCTCCCCCCACCCAATGCGAGACGTGGCCAGATCCCATCCAACACACGGTTTAATTTTCATGGGGCTCTGGGATC
AAAAGAACAGAAACAGCAACAACAAAAGCCCAGCCGCTGTCTGATTTTAAGCTGGCAAAGTGGGAAAAATAAAGTGTTGAGTAAACAGAC
CAAGTTGGGGTGCTATGGGCCAGGTTTCTGAAGTTGGGTGGAGGTGGAGGCCACCGGCAGTGAGTACAACGCCCAGGGGAAGCATGTGAG
TGGGAGGAAGAAAAGAGAGTTTTCTGGAGCTGTTGCAATGTGTATGCTGGTGAAATCTACTTGAGCATTAAGCAGTATCTCCCAGCATTG
TTAGCTACTGAGTGGCACATCTTCAGTACGCATGATTCGTGGGGGACTCAGGCAGAGGTAAAAGTGTGAAACTTTTCAGCATTACCTAAG
AAGCAAAGGCTCAATTTTGGCTGCTTCATTCTTATCTCTTCTGCCACAGTTCTAACGTGCCTGATCTACTGAGACCAAGGATGACCAATG
ACTCAGAAGGGAAAATGGGATTTAAACACCCAAAGCCTAAAGAATGTTTTTTGATACAACCAAAGGAAAGAAAAGAGAATACCACCAAGA
CCAGGAAAAGAAGAAAGAAGAAAATTACTGATGTTCTTGCAAAATCAGAACCAAAACCAGGGTTACCTGAAGACCTACAGAAGCTGATGA
AGGACTATTATAGCAGCAGACGCTTGGTGATTGAATTAGAAGAACTGAACCTGCCAGACTCCTGTTTCCTCAAGGCCAATGATTTGACTC
ACAGTCTTTCCTCATACCTAAAAGAAATTTGTCCTAAGTGGGTAAAACTTAGGAAGAACCACAGTGAGAAGAAATCGGTCCTGATGCTGA
TCATCTGCAGCTCGGCCGTCCGAGCCCTGGAGCTCATTAGGTCGATGACAGCATTCAGAGGAGACGGCAAAGTTATAAAATTATTTGCAA
AGCACATAAAGGTCCAGGCGCAGGTAAAGTTGCTGGAGAAGCGTGTGGTGCACCTGGGTGTAGGAACTCCGGGGAGAATTAAAGAACTTG
TTAAACAAGGTGGCCTTAATTTGAGCCCCTTAAAATTTCTGGTTTTTGACTGGAACTGGAGAGATCAGAAGTTGAGGAGAATGATGGACA
TTCCCGAGATAAGAAAGGAGGTATTCGAACTTCTGGAAATGGGAGTGCTCAGTCTGTGCAAGTCAGAATCCTTGAAACTGGGCCTTTTCT
AAGTCTGTGTCCTAATGAAGATTCCAGTTTTCACAGTAGAAGTTGCATCTTATTTAATGACTCTGATACATTGCAAGCACTCAGTAAATA
TCAGCAAATAGTTTATGTTAATTGTGTCAACAGATGGATCACTGGAATGTGGGGATTCTGAAACAGAAATGAAACTGTCCTTTTGACAAC

>92120_92120_1_TMEM45A-CMSS1_TMEM45A_chr3_100238451_ENST00000403410_CMSS1_chr3_99879273_ENST00000421999_length(amino acids)=263AA_BP=35
MLHSYLFCHSSNVPDLLRPRMTNDSEGKMGFKHPKPKECFLIQPKERKENTTKTRKRRKKKITDVLAKSEPKPGLPEDLQKLMKDYYSSR
RLVIELEELNLPDSCFLKANDLTHSLSSYLKEICPKWVKLRKNHSEKKSVLMLIICSSAVRALELIRSMTAFRGDGKVIKLFAKHIKVQA

--------------------------------------------------------------
>92120_92120_2_TMEM45A-CMSS1_TMEM45A_chr3_100238452_ENST00000403410_CMSS1_chr3_99879274_ENST00000421999_length(transcript)=1567nt_BP=665nt
GCGGGCCGACGTCAGCCGAGCACGTCCCCCACGTCCTCTCCTTCTCGCCACTTATTATTTATTCGTTTTCCCAAAGAAGCGACTAGGGAC
CCAAGTTTAAAAATTCCTCCCCCCACCCAATGCGAGACGTGGCCAGATCCCATCCAACACACGGTTTAATTTTCATGGGGCTCTGGGATC
AAAAGAACAGAAACAGCAACAACAAAAGCCCAGCCGCTGTCTGATTTTAAGCTGGCAAAGTGGGAAAAATAAAGTGTTGAGTAAACAGAC
CAAGTTGGGGTGCTATGGGCCAGGTTTCTGAAGTTGGGTGGAGGTGGAGGCCACCGGCAGTGAGTACAACGCCCAGGGGAAGCATGTGAG
TGGGAGGAAGAAAAGAGAGTTTTCTGGAGCTGTTGCAATGTGTATGCTGGTGAAATCTACTTGAGCATTAAGCAGTATCTCCCAGCATTG
TTAGCTACTGAGTGGCACATCTTCAGTACGCATGATTCGTGGGGGACTCAGGCAGAGGTAAAAGTGTGAAACTTTTCAGCATTACCTAAG
AAGCAAAGGCTCAATTTTGGCTGCTTCATTCTTATCTCTTCTGCCACAGTTCTAACGTGCCTGATCTACTGAGACCAAGGATGACCAATG
ACTCAGAAGGGAAAATGGGATTTAAACACCCAAAGCCTAAAGAATGTTTTTTGATACAACCAAAGGAAAGAAAAGAGAATACCACCAAGA
CCAGGAAAAGAAGAAAGAAGAAAATTACTGATGTTCTTGCAAAATCAGAACCAAAACCAGGGTTACCTGAAGACCTACAGAAGCTGATGA
AGGACTATTATAGCAGCAGACGCTTGGTGATTGAATTAGAAGAACTGAACCTGCCAGACTCCTGTTTCCTCAAGGCCAATGATTTGACTC
ACAGTCTTTCCTCATACCTAAAAGAAATTTGTCCTAAGTGGGTAAAACTTAGGAAGAACCACAGTGAGAAGAAATCGGTCCTGATGCTGA
TCATCTGCAGCTCGGCCGTCCGAGCCCTGGAGCTCATTAGGTCGATGACAGCATTCAGAGGAGACGGCAAAGTTATAAAATTATTTGCAA
AGCACATAAAGGTCCAGGCGCAGGTAAAGTTGCTGGAGAAGCGTGTGGTGCACCTGGGTGTAGGAACTCCGGGGAGAATTAAAGAACTTG
TTAAACAAGGTGGCCTTAATTTGAGCCCCTTAAAATTTCTGGTTTTTGACTGGAACTGGAGAGATCAGAAGTTGAGGAGAATGATGGACA
TTCCCGAGATAAGAAAGGAGGTATTCGAACTTCTGGAAATGGGAGTGCTCAGTCTGTGCAAGTCAGAATCCTTGAAACTGGGCCTTTTCT
AAGTCTGTGTCCTAATGAAGATTCCAGTTTTCACAGTAGAAGTTGCATCTTATTTAATGACTCTGATACATTGCAAGCACTCAGTAAATA
TCAGCAAATAGTTTATGTTAATTGTGTCAACAGATGGATCACTGGAATGTGGGGATTCTGAAACAGAAATGAAACTGTCCTTTTGACAAC

>92120_92120_2_TMEM45A-CMSS1_TMEM45A_chr3_100238452_ENST00000403410_CMSS1_chr3_99879274_ENST00000421999_length(amino acids)=263AA_BP=35
MLHSYLFCHSSNVPDLLRPRMTNDSEGKMGFKHPKPKECFLIQPKERKENTTKTRKRRKKKITDVLAKSEPKPGLPEDLQKLMKDYYSSR
RLVIELEELNLPDSCFLKANDLTHSLSSYLKEICPKWVKLRKNHSEKKSVLMLIICSSAVRALELIRSMTAFRGDGKVIKLFAKHIKVQA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMEM45A-CMSS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM45A-CMSS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM45A-CMSS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource