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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMEM45B-OPCML (FusionGDB2 ID:92126)

Fusion Gene Summary for TMEM45B-OPCML

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM45B-OPCML
	Fusion gene ID: 92126
		Hgene	Tgene
	Gene symbol	TMEM45B	OPCML
	Gene ID	120224	4978
	Gene name	transmembrane protein 45B	opioid binding protein/cell adhesion molecule like
	Synonyms	-	IGLON1\|OBCAM\|OPCM
	Cytomap	11q24.3	11q25
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 45B	opioid-binding protein/cell adhesion moleculeIgLON family member 1opioid binding protein/cell adhesion molecule-like preprotein
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000281441, ENST00000524567, ENST00000525709,	ENST00000331898, ENST00000374778, ENST00000529038, ENST00000541867, ENST00000524381,
Fusion gene scores	* DoF score	5 X 3 X 5=75	12 X 10 X 9=1080
	# samples	5	14
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/1080*10)=-2.94753258010586 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TMEM45B [Title/Abstract] AND OPCML [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM45B(129724711)-OPCML(132307253), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TMEM45B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across OPCML (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-6961	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-

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Fusion Gene ORF analysis for TMEM45B-OPCML

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000281441	ENST00000331898	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-
5CDS-5UTR	ENST00000281441	ENST00000374778	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-
5CDS-5UTR	ENST00000281441	ENST00000529038	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-
5CDS-5UTR	ENST00000281441	ENST00000541867	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-
5CDS-5UTR	ENST00000524567	ENST00000331898	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-
5CDS-5UTR	ENST00000524567	ENST00000374778	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-
5CDS-5UTR	ENST00000524567	ENST00000529038	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-
5CDS-5UTR	ENST00000524567	ENST00000541867	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-
In-frame	ENST00000281441	ENST00000524381	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-
In-frame	ENST00000524567	ENST00000524381	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-
intron-3CDS	ENST00000525709	ENST00000524381	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-
intron-5UTR	ENST00000525709	ENST00000331898	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-
intron-5UTR	ENST00000525709	ENST00000374778	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-
intron-5UTR	ENST00000525709	ENST00000529038	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-
intron-5UTR	ENST00000525709	ENST00000541867	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000281441

TMEM45B

chr11

129724711

ENST00000524381

OPCML

chr11

132307253

6197

473

984

327

ENST00000524567

TMEM45B

chr11

129724711

ENST00000524381

OPCML

chr11

132307253

6390

666

278

1177

299

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000281441	ENST00000524381	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-	0.000520964	0.9994791
ENST00000524567	ENST00000524381	TMEM45B	chr11	129724711	+	OPCML	chr11	132307253	-	0.000495973	0.99950397

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Fusion Genomic Features for TMEM45B-OPCML

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM45B-OPCML

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:129724711/chr11:132307253)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM45B

chr11:129724711

chr11:132307253

ENST00000281441

47_67

128

276.0

Transmembrane

Helical

Hgene

TMEM45B

chr11:129724711

chr11:132307253

ENST00000281441

7_27

128

276.0

Transmembrane

Helical

Hgene

TMEM45B

chr11:129724711

chr11:132307253

ENST00000281441

94_114

128

276.0

Transmembrane

Helical

Hgene

TMEM45B

chr11:129724711

chr11:132307253

ENST00000524567

47_67

128

276.0

Transmembrane

Helical

Hgene

TMEM45B

chr11:129724711

chr11:132307253

ENST00000524567

7_27

128

276.0

Transmembrane

Helical

Hgene

TMEM45B

chr11:129724711

chr11:132307253

ENST00000524567

94_114

128

276.0

Transmembrane

Helical

Tgene

OPCML

chr11:129724711

chr11:132307253

ENST00000331898

223_310

175

346.0

Domain

Note=Ig-like C2-type 3

Tgene

OPCML

chr11:129724711

chr11:132307253

ENST00000374778

136_219

134

305.0

Domain

Note=Ig-like C2-type 2

Tgene

OPCML

chr11:129724711

chr11:132307253

ENST00000374778

223_310

134

305.0

Domain

Note=Ig-like C2-type 3

Tgene

OPCML

chr11:129724711

chr11:132307253

ENST00000524381

223_310

168

339.0

Domain

Note=Ig-like C2-type 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM45B

chr11:129724711

chr11:132307253

ENST00000281441

116_136

128

276.0

Transmembrane

Helical

Hgene

TMEM45B

chr11:129724711

chr11:132307253

ENST00000281441

146_166

128

276.0

Transmembrane

Helical

Hgene

TMEM45B

chr11:129724711

chr11:132307253

ENST00000281441

180_200

128

276.0

Transmembrane

Helical

Hgene

TMEM45B

chr11:129724711

chr11:132307253

ENST00000281441

212_232

128

276.0

Transmembrane

Helical

Hgene

TMEM45B

chr11:129724711

chr11:132307253

ENST00000524567

116_136

128

276.0

Transmembrane

Helical

Hgene

TMEM45B

chr11:129724711

chr11:132307253

ENST00000524567

146_166

128

276.0

Transmembrane

Helical

Hgene

TMEM45B

chr11:129724711

chr11:132307253

ENST00000524567

180_200

128

276.0

Transmembrane

Helical

Hgene

TMEM45B

chr11:129724711

chr11:132307253

ENST00000524567

212_232

128

276.0

Transmembrane

Helical

Tgene

OPCML

chr11:129724711

chr11:132307253

ENST00000331898

136_219

175

346.0

Domain

Note=Ig-like C2-type 2

Tgene

OPCML

chr11:129724711

chr11:132307253

ENST00000331898

39_126

175

346.0

Domain

Note=Ig-like C2-type 1

Tgene

OPCML

chr11:129724711

chr11:132307253

ENST00000374778

39_126

134

305.0

Domain

Note=Ig-like C2-type 1

Tgene

OPCML

chr11:129724711

chr11:132307253

ENST00000524381

136_219

168

339.0

Domain

Note=Ig-like C2-type 2

Tgene

OPCML

chr11:129724711

chr11:132307253

ENST00000524381

39_126

168

339.0

Domain

Note=Ig-like C2-type 1

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Fusion Gene Sequence for TMEM45B-OPCML

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>92126_92126_1_TMEM45B-OPCML_TMEM45B_chr11_129724711_ENST00000281441_OPCML_chr11_132307253_ENST00000524381_length(transcript)=6197nt_BP=473nt
CCTGGAGCTGCACCTGCTTCTGGGCGGACGCACTTGGCGCGCGGCGCGGGCTGCAGACGGCTGCGAGGCGCTGGGCACAGGTGTCCTGAT
GGCAAATTTCAAGGGCCACGCGCTTCCAGGGAGTTTCTTCCTGATCATTGGGCTGTGTTGGTCAGTGAAGTACCCGCTGAAGTACTTTAG
CCACACGCGGAAGAACAGCCCACTACATTACTATCAGCGTCTCGAGATCGTCGAAGCCGCAATTAGGACTTTGTTTTCCGTCACTGGGAT
CCTGGCAGAGCAGTTTGTTCCGGATGGGCCCCACCTGCACCTCTACCATGAGAACCACTGGATAAAGTTAATGAATTGGCAGCACAGCAC
CATGTACCTATTCTTTGCAGTCTCAGGAATTGTTGACATGCTCACCTATCTGGTCAGCCACGTTCCCTTGGGGGTGGACAGACTGGTTAT
GGCTGTGGCAGTATTCATGGAAGAAGGCCAGGGCTTTGTAAGTGAGGATGAGTACCTGGAGATCTCTGACATCAAGCGAGACCAGTCCGG
GGAGTACGAATGCAGCGCGTTGAACGATGTCGCTGCGCCCGATGTGCGGAAAGTAAAAATCACTGTAAACTATCCTCCCTATATCTCAAA
AGCCAAGAACACTGGTGTTTCAGTCGGTCAGAAGGGCATCCTGAGCTGTGAAGCCTCTGCAGTCCCCATGGCTGAATTCCAGTGGTTCAA
GGAAGAAACCAGGTTAGCCACTGGTCTGGATGGAATGAGGATTGAAAACAAAGGCCGCATGTCCACTCTGACTTTCTTCAATGTTTCAGA
AAAGGATTATGGGAACTATACTTGTGTGGCCACGAACAAGCTTGGGAACACCAATGCCAGCATCACATTGTATGGGCCTGGAGCAGTCAT
TGATGGTGTAAACTCGGCCTCCAGAGCACTGGCTTGTCTCTGGCTATCAGGGACCCTCTTAGCCCACTTCTTCATCAAGTTTTGATAAGA
AATCCTAGGTCCTCTGAGCAACGCCTGCTTCTCCATATCACAGACTTTAATCTACACTGCGGAGAGCAAACCAGCTTGGGCTTCTTTTTG
TTTTTTTCTGTTATTCTAGATTTGTTTTCTTTTTGTTTTTGTTTATTTGTTTGTTTGCTTTTATTTCCAGCTTGAATGAGTGGGGTTGGG
GGCGGGGTGGGCAGGGTTCTACCACGTGTAGGATAATCATTCATTGGTGTGTCCAAAAATGGGGTCTGCTCCTGCTACCTTGACCCTTCC
CTTTCCTCTGCTTCTCTCCTCATCATCATTCCCAACAACATCCTCTGCCACACACAACAAAACGTAAGTTTCATTTGGGCAAAAATTGAG
CCTCACAATAAACACCCTGAAGACACAACTTGACTTATAACATAGTGCACAGCAAGAGCTACATCCAAGTGTCCTATTATCTGTGATTAT
TTTCTTAATGACAATGTACATATGCCCCCATCCATGTTAATTATTATCTAATTCCATTAGGGTTCACGTCTTTTCTTTCTGGGACACTAT
CCTACTATATCCATATCTATAGATTTCAATATAGATGATTGTGCCATCTTCTGTAGCCCCTCCGCTCTACTCATTCCTTCCACCATCTGC
AGAGATTTGAAGTTTGGGGCTATGCATGAAACCCAACACTAAATTTTGCAAGTCAAGTAACCAAAAAAGGGGGAGGCATTTTGAAGATAG
AACCTCTATTTTAAAAAGAGAAGTTCAACTCATAAACGTGATTGATAGGTGGCTGATTTATTTAGGTTTTGTCAAGCTATCTATCAAAGT
AATGGTACAGTTACCCATCTACTCAAATATCTGATTTATCTCACCATCCAATTATCTACCCACCTGTCTTCCTCTCTAGCAATCTATTTA
CTGTTTATCAATCTATCAATGTAATTGTCTAACACTCCTTTCTATTCTCTCCCTACTACTCACTATCAATTCATCCCCATATGAATCTCT
AACCATATTGTATCTCTCCCACTGTATTCATTTATACACCATCAGCAGACATTGGCATCTTCAAAATTATCTTTCAACTTCTGTGAAAGC
CAACGATCTCACAGGTTAACAAAATACAAAAGCAATACCCTGTGTTGTGGACTCTTTAAAATCTGGTATCCTATCCACCCAAGGGAGACA
CTAACAGATAGGCCAAAGTAGCAAGCTAATGATCAGTCACTCACTATTCCCAGAAGAGCCTGTGTTTTCTAAAACACTTTCTTGGGAAGC
AGATCAGCCTAGAAAAGTTTTGATTAGCACTGTGGTTTTCCTTTTGCACTTGAAGGACAAAGGTGCCAGCCTTTATGCTTCTCTCAACCC
TTCAAGAAAGTACATGTCAGGAACCTATGGCTGGCTTTCCTTAGCAGCAAGAACTTGAGAGAAAAACACATCTGTCTCTGCAATGCAAAG
TGAAGAGTCCACCCGCCTGAGTGGGATGACTTCAGCTAGAGTCTCCTTTCTGCTCCAGTTCTGGTTTAATCTGTTTGAAAACTATCCAGT
AAAAAGCTGATGGAGGCCAATTACATGGCGGGTGTATTGACAACTCTGGTATTTGTTTCAGGAAGCTCTTCTAAGCTGAGGGCACTTGAG
CAACTGACTTAATTTTCAAGCACTTGATTAACACAACACTGCAAACAGAAGGGAGAAAGTGTCAGTGACACAGTTTCCTCTGATGCAGCT
GCTTCTCCAATGGCTTTGGGGAAGAACTTCACCAGCTCTTCAGGTTCAAAGCAGACCCAGCATACAAACAAGAGCTGAGCCACCTTTGCT
GTCTTGTCTCCTGGGACGAGAAGGACTCATCCAGCAAAGTTGCCTGGGATTCAAAATAAAGGCATTGCAGACCGCACAGGTGTGCTGCAG
GGACTGATCCACAGAGAGGATGAGAATGCAGCATCAATCGCAGACCTGCCCTGCCTCAGTTGGAAAACCTTTTCAGGCCCTCAGTCTAAA
AAATAAAAAATATGAGCACCATTGAATTCTGTGCCCTTAATGCTTAACTGGTCTTCTTCCTCTGGTATCAGTGTCCTCTTTGTTTTTGTC
CATCAAGGCACATGAGTGTGACCTCTGCCATGGGGAAACACACACAGAGATATCTATACATATATACATACATACAAACATAGGCTATCT
TGGCACACTAAATGCTAAGCACTGTCTTAAGAGGTAGAGCTGGTGTGAGTGAAATTAATGTTACATTTTCCAGCTGTAAACAGACATCTG
CATTTCCTAGTGAGCTGCCAGGAGCCAGATTCGGGAACCGTAACTGATGTGCCAGGAATGGTGCATTGATTCCCAGTTCCAGGGATGATC
ATGAGCAGGCGCAAAATCAGAATTAAAGGTCGCACATAGACGTTTCAGATCTGTCACCACCTTCAGCATCTGGAGTTGAGTTGGTGTCAG
ATAGTGTATGAGAATTAAATGTGTCATCTGAGCATGCTACTGATGATAAATTTGTTACTTTGGAGTTGAATAAATGTGAAGGCTGTGAAG
AGTGGACAGTCTTGGAGAACACAGTGCTTGAAATGGACAAGCTGGACCTATTCCTCACTCCAAGACTTGTTCTACAGGAAAGGGTCCATG
CTCCTTTGGCCAAGATCATCAGAACCTCTCAACCCAACAAGGCTGGCTTCAGGGCCACTATGGAACCCTGCTGTTCCCCCTTCCAAAGGA
TACTAAGATGCCCCTCTGGTGGGTACCTATCCCAGCCACGTTTCAGAGGGAGAGAAATGCTACAGTTGATCCTCATCTGTCTGGGGTAAA
GACAACAAAGTAAATACAACCCAAGGCAACTGGGGTACTCACTGGGAGTGAAAATGACTTCTTCACAACAGACATATTTCTGCTTCTGTG
TTTTTGTGTTTCTTTGGTGGGGATGGCTTCATGGGAGAGTGGCTGTCACCCATCATTTTGAAGCATATAGAACAACAAATGCTTACACAA
GACAATATCCACACTTTTCCAACTTCACACACGGAGAGTACATGGAGAATGCCTACAGGCTAGATTTGTTCAGGGTGCCAGTAGTGGGCA
TGGGGTGGGGGCAAGGCAGGACAAAACATACAAGTCTGAGCAAGTACATCTCTTGCAGGTTTTCCACATGAAAAGGAAGCCAAATAAGTC
CTGTTAGGAGATTAGGTGAGAGGAATTAGCAATGTAGGGACTCTGAAACCCTTCCCCTTCCCAAAACAGAGTTCATATGCACTTCCACCA
AAGTAATGCCAATGAAAGTGCTCGTGTTAAGGCTGCAGCCAAGCTTGTTTTTCAGTAGTTTAATGTCAAGTGCCTGATACAGTCGACTGC
AAGTCTAAACAAGCATGTTTAGTTTTTCTCATTCTTGCTTTAATTCAGGGAGGGGGAGATGTAGAGAAGTGGTTGTGAAAACATGTACAG
GCTTTATGCAGAGCACTGCGCATGGCTGTTCTGCTGCAACTGTGCTCCACGAAACAGAAGAAAAGGTAAGGTGTTGTGTCACAAAGAGGC
CCCAGTCTCTTTCTTCTTACATCCATGCCTCTTACTAGATGATACATTTACAGATTGGGCAGTTTGTTCTCAAAACCTGGGTGAGAAGAC
TATTCCTGGACTCTAGCAACTTCAAAACTGAGGCTGGGTTTCAGAATCTTTTTCTGCATCAATTCAGTCAATTTGCCTTCAACAAAGAGA
AGTCAGCAAGTTCTATTTATGCTGAAAGAACTATTCCATGAGAAAAGCAGAGAACCCCAAAGTGGGCAGGCAACCCCGACGAGAGCTTAT
CCCTGTGGCGGCATCAGGAGTGGCTGTACATTGAATTTTCAAGTGCTGGTTGGCTGTCGCCAGCCCATGGTAGGAGGGGAGGAATGGCTT
AAGATGAGGTAAGATCTGGTGGTGGGGCATCTTTCCTCAATTCCATACTGACTTTGATCTTGAGAAAGAAAAACTGGCTATGCATTACCT
AAAACCAGTCCAAAATGAAACAGACCAACACACACACAAAAGCAAATTGTCAATCCCTTTGGAATTAAGGGAAGCAGCATAAGGTTTTTC
TTTTTGGAAAAAATGCATTTATTTTCTTTTTCTCCAACAGCAAGAATCTTTTGTTTTCATTTTGCACGTGACCTTATCTTGGAAACTCTT
ATACCCAATTGCCTCCCCTCCTATTATTCAGAGCTTCCCTGTCTTTTTACTTGAAGACAAATAAGTTTGAGCACTTGAGTAAAACTTCAC
AGGTGTGTAAGTAGGAAGGCAACATTTTCAAAAAGAGACCATATGATGAGAACGCCTAATGATCACCACATGCAAACAAACAAAACTGCC
AGTCTCATTTCCCACATTTCTTACTTAAGAGAAGAGAAGTAAATGAAAGGAAGAAGAAATAGATTTGTAATTAAAGATGTGGCAAAAAAG
ATAGGGCTGAGCCAGTTCAATTTAGCCTTCAGGTGCAGAATACTTAGAGTCCAAAGAAATGTGGAGTGGACTTAATTAGATGCAGTTGTC
TTTATCCTGAAAGTAGTGAGCTAAGCCTAATTTCCAGCATTTTGAAAGAGATTCCTTTTTGTTTCTTTCCATGGTGCCCTCTTTAAGGCA
CAGAGTTGCTCCACACCACTGGGTGGAGAAAGAAAGATTGCGAACCCTCGACCATCCTTTTGAGGCTACATTCTATGTTATTTGGCAGAT
TTATAAAGCTATCAGTAATAACAATGCTATGTACTGCAAGCTGCCCTTGTGTTAGTTAAAGGGAGCATTTTTAATCGTTCGGAAATTTTC
GTGACATGTCAAGTGCAGTTGTGAGGACTGTGTGGGTGAACGAAAATGTGTCTGTCAAGTTCAGAGTCCTTTAGATTTAAAAAAAAATTA
TGACTTATCAATGGTGCCGTTATAGCTGTGTCAGACAATGGGTGTGCCCATTCTCACAATTATCCTTCAAAAAAAATCTATGTTCAAATG
CTTTAAAAATTTATCACACGATACAAGAGTATGACTTTGTCAGCCTTCTAGAGTTCTTTTTTTCTTTTATTTTCTTTCGTATTTTTTCCT
TCAAAAAATCAATGAAGACTTGATTTCTGTCAATAATTGTATCAAGGGTGAATATACTACCTGAATTTTGTGCATGTTACATTGTAGTTG

>92126_92126_1_TMEM45B-OPCML_TMEM45B_chr11_129724711_ENST00000281441_OPCML_chr11_132307253_ENST00000524381_length(amino acids)=327AA_BP=152
LELHLLLGGRTWRAARAADGCEALGTGVLMANFKGHALPGSFFLIIGLCWSVKYPLKYFSHTRKNSPLHYYQRLEIVEAAIRTLFSVTGI
LAEQFVPDGPHLHLYHENHWIKLMNWQHSTMYLFFAVSGIVDMLTYLVSHVPLGVDRLVMAVAVFMEEGQGFVSEDEYLEISDIKRDQSG
EYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTFFNVSE

--------------------------------------------------------------
>92126_92126_2_TMEM45B-OPCML_TMEM45B_chr11_129724711_ENST00000524567_OPCML_chr11_132307253_ENST00000524381_length(transcript)=6390nt_BP=666nt
TTTTTTTATGTTTAGTAGAGACAGGGTTTCACCATGTTTGTCAGGCTTATCTCGAACTCCTGACCTCAGGTGATCTGCCTGCCTCGCCCT
CCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCACCTGGCCTCTCATGTTTTTCTATAAGCAGTTAAGAGAAGCCACACAGCATCCTG
AACACTTTGCTTTCTATCTCTTCTGCCAAATATCCTAGGTCATCATTCTTAAGTTCTGCCCTCCATGAAGTCCTAGGAAACGACATAATT
CAGGTGTCCTGATGGCAAATTTCAAGGGCCACGCGCTTCCAGGGAGTTTCTTCCTGATCATTGGGCTGTGTTGGTCAGTGAAGTACCCGC
TGAAGTACTTTAGCCACACGCGGAAGAACAGCCCACTACATTACTATCAGCGTCTCGAGATCGTCGAAGCCGCAATTAGGACTTTGTTTT
CCGTCACTGGGATCCTGGCAGAGCAGTTTGTTCCGGATGGGCCCCACCTGCACCTCTACCATGAGAACCACTGGATAAAGTTAATGAATT
GGCAGCACAGCACCATGTACCTATTCTTTGCAGTCTCAGGAATTGTTGACATGCTCACCTATCTGGTCAGCCACGTTCCCTTGGGGGTGG
ACAGACTGGTTATGGCTGTGGCAGTATTCATGGAAGAAGGCCAGGGCTTTGTAAGTGAGGATGAGTACCTGGAGATCTCTGACATCAAGC
GAGACCAGTCCGGGGAGTACGAATGCAGCGCGTTGAACGATGTCGCTGCGCCCGATGTGCGGAAAGTAAAAATCACTGTAAACTATCCTC
CCTATATCTCAAAAGCCAAGAACACTGGTGTTTCAGTCGGTCAGAAGGGCATCCTGAGCTGTGAAGCCTCTGCAGTCCCCATGGCTGAAT
TCCAGTGGTTCAAGGAAGAAACCAGGTTAGCCACTGGTCTGGATGGAATGAGGATTGAAAACAAAGGCCGCATGTCCACTCTGACTTTCT
TCAATGTTTCAGAAAAGGATTATGGGAACTATACTTGTGTGGCCACGAACAAGCTTGGGAACACCAATGCCAGCATCACATTGTATGGGC
CTGGAGCAGTCATTGATGGTGTAAACTCGGCCTCCAGAGCACTGGCTTGTCTCTGGCTATCAGGGACCCTCTTAGCCCACTTCTTCATCA
AGTTTTGATAAGAAATCCTAGGTCCTCTGAGCAACGCCTGCTTCTCCATATCACAGACTTTAATCTACACTGCGGAGAGCAAACCAGCTT
GGGCTTCTTTTTGTTTTTTTCTGTTATTCTAGATTTGTTTTCTTTTTGTTTTTGTTTATTTGTTTGTTTGCTTTTATTTCCAGCTTGAAT
GAGTGGGGTTGGGGGCGGGGTGGGCAGGGTTCTACCACGTGTAGGATAATCATTCATTGGTGTGTCCAAAAATGGGGTCTGCTCCTGCTA
CCTTGACCCTTCCCTTTCCTCTGCTTCTCTCCTCATCATCATTCCCAACAACATCCTCTGCCACACACAACAAAACGTAAGTTTCATTTG
GGCAAAAATTGAGCCTCACAATAAACACCCTGAAGACACAACTTGACTTATAACATAGTGCACAGCAAGAGCTACATCCAAGTGTCCTAT
TATCTGTGATTATTTTCTTAATGACAATGTACATATGCCCCCATCCATGTTAATTATTATCTAATTCCATTAGGGTTCACGTCTTTTCTT
TCTGGGACACTATCCTACTATATCCATATCTATAGATTTCAATATAGATGATTGTGCCATCTTCTGTAGCCCCTCCGCTCTACTCATTCC
TTCCACCATCTGCAGAGATTTGAAGTTTGGGGCTATGCATGAAACCCAACACTAAATTTTGCAAGTCAAGTAACCAAAAAAGGGGGAGGC
ATTTTGAAGATAGAACCTCTATTTTAAAAAGAGAAGTTCAACTCATAAACGTGATTGATAGGTGGCTGATTTATTTAGGTTTTGTCAAGC
TATCTATCAAAGTAATGGTACAGTTACCCATCTACTCAAATATCTGATTTATCTCACCATCCAATTATCTACCCACCTGTCTTCCTCTCT
AGCAATCTATTTACTGTTTATCAATCTATCAATGTAATTGTCTAACACTCCTTTCTATTCTCTCCCTACTACTCACTATCAATTCATCCC
CATATGAATCTCTAACCATATTGTATCTCTCCCACTGTATTCATTTATACACCATCAGCAGACATTGGCATCTTCAAAATTATCTTTCAA
CTTCTGTGAAAGCCAACGATCTCACAGGTTAACAAAATACAAAAGCAATACCCTGTGTTGTGGACTCTTTAAAATCTGGTATCCTATCCA
CCCAAGGGAGACACTAACAGATAGGCCAAAGTAGCAAGCTAATGATCAGTCACTCACTATTCCCAGAAGAGCCTGTGTTTTCTAAAACAC
TTTCTTGGGAAGCAGATCAGCCTAGAAAAGTTTTGATTAGCACTGTGGTTTTCCTTTTGCACTTGAAGGACAAAGGTGCCAGCCTTTATG
CTTCTCTCAACCCTTCAAGAAAGTACATGTCAGGAACCTATGGCTGGCTTTCCTTAGCAGCAAGAACTTGAGAGAAAAACACATCTGTCT
CTGCAATGCAAAGTGAAGAGTCCACCCGCCTGAGTGGGATGACTTCAGCTAGAGTCTCCTTTCTGCTCCAGTTCTGGTTTAATCTGTTTG
AAAACTATCCAGTAAAAAGCTGATGGAGGCCAATTACATGGCGGGTGTATTGACAACTCTGGTATTTGTTTCAGGAAGCTCTTCTAAGCT
GAGGGCACTTGAGCAACTGACTTAATTTTCAAGCACTTGATTAACACAACACTGCAAACAGAAGGGAGAAAGTGTCAGTGACACAGTTTC
CTCTGATGCAGCTGCTTCTCCAATGGCTTTGGGGAAGAACTTCACCAGCTCTTCAGGTTCAAAGCAGACCCAGCATACAAACAAGAGCTG
AGCCACCTTTGCTGTCTTGTCTCCTGGGACGAGAAGGACTCATCCAGCAAAGTTGCCTGGGATTCAAAATAAAGGCATTGCAGACCGCAC
AGGTGTGCTGCAGGGACTGATCCACAGAGAGGATGAGAATGCAGCATCAATCGCAGACCTGCCCTGCCTCAGTTGGAAAACCTTTTCAGG
CCCTCAGTCTAAAAAATAAAAAATATGAGCACCATTGAATTCTGTGCCCTTAATGCTTAACTGGTCTTCTTCCTCTGGTATCAGTGTCCT
CTTTGTTTTTGTCCATCAAGGCACATGAGTGTGACCTCTGCCATGGGGAAACACACACAGAGATATCTATACATATATACATACATACAA
ACATAGGCTATCTTGGCACACTAAATGCTAAGCACTGTCTTAAGAGGTAGAGCTGGTGTGAGTGAAATTAATGTTACATTTTCCAGCTGT
AAACAGACATCTGCATTTCCTAGTGAGCTGCCAGGAGCCAGATTCGGGAACCGTAACTGATGTGCCAGGAATGGTGCATTGATTCCCAGT
TCCAGGGATGATCATGAGCAGGCGCAAAATCAGAATTAAAGGTCGCACATAGACGTTTCAGATCTGTCACCACCTTCAGCATCTGGAGTT
GAGTTGGTGTCAGATAGTGTATGAGAATTAAATGTGTCATCTGAGCATGCTACTGATGATAAATTTGTTACTTTGGAGTTGAATAAATGT
GAAGGCTGTGAAGAGTGGACAGTCTTGGAGAACACAGTGCTTGAAATGGACAAGCTGGACCTATTCCTCACTCCAAGACTTGTTCTACAG
GAAAGGGTCCATGCTCCTTTGGCCAAGATCATCAGAACCTCTCAACCCAACAAGGCTGGCTTCAGGGCCACTATGGAACCCTGCTGTTCC
CCCTTCCAAAGGATACTAAGATGCCCCTCTGGTGGGTACCTATCCCAGCCACGTTTCAGAGGGAGAGAAATGCTACAGTTGATCCTCATC
TGTCTGGGGTAAAGACAACAAAGTAAATACAACCCAAGGCAACTGGGGTACTCACTGGGAGTGAAAATGACTTCTTCACAACAGACATAT
TTCTGCTTCTGTGTTTTTGTGTTTCTTTGGTGGGGATGGCTTCATGGGAGAGTGGCTGTCACCCATCATTTTGAAGCATATAGAACAACA
AATGCTTACACAAGACAATATCCACACTTTTCCAACTTCACACACGGAGAGTACATGGAGAATGCCTACAGGCTAGATTTGTTCAGGGTG
CCAGTAGTGGGCATGGGGTGGGGGCAAGGCAGGACAAAACATACAAGTCTGAGCAAGTACATCTCTTGCAGGTTTTCCACATGAAAAGGA
AGCCAAATAAGTCCTGTTAGGAGATTAGGTGAGAGGAATTAGCAATGTAGGGACTCTGAAACCCTTCCCCTTCCCAAAACAGAGTTCATA
TGCACTTCCACCAAAGTAATGCCAATGAAAGTGCTCGTGTTAAGGCTGCAGCCAAGCTTGTTTTTCAGTAGTTTAATGTCAAGTGCCTGA
TACAGTCGACTGCAAGTCTAAACAAGCATGTTTAGTTTTTCTCATTCTTGCTTTAATTCAGGGAGGGGGAGATGTAGAGAAGTGGTTGTG
AAAACATGTACAGGCTTTATGCAGAGCACTGCGCATGGCTGTTCTGCTGCAACTGTGCTCCACGAAACAGAAGAAAAGGTAAGGTGTTGT
GTCACAAAGAGGCCCCAGTCTCTTTCTTCTTACATCCATGCCTCTTACTAGATGATACATTTACAGATTGGGCAGTTTGTTCTCAAAACC
TGGGTGAGAAGACTATTCCTGGACTCTAGCAACTTCAAAACTGAGGCTGGGTTTCAGAATCTTTTTCTGCATCAATTCAGTCAATTTGCC
TTCAACAAAGAGAAGTCAGCAAGTTCTATTTATGCTGAAAGAACTATTCCATGAGAAAAGCAGAGAACCCCAAAGTGGGCAGGCAACCCC
GACGAGAGCTTATCCCTGTGGCGGCATCAGGAGTGGCTGTACATTGAATTTTCAAGTGCTGGTTGGCTGTCGCCAGCCCATGGTAGGAGG
GGAGGAATGGCTTAAGATGAGGTAAGATCTGGTGGTGGGGCATCTTTCCTCAATTCCATACTGACTTTGATCTTGAGAAAGAAAAACTGG
CTATGCATTACCTAAAACCAGTCCAAAATGAAACAGACCAACACACACACAAAAGCAAATTGTCAATCCCTTTGGAATTAAGGGAAGCAG
CATAAGGTTTTTCTTTTTGGAAAAAATGCATTTATTTTCTTTTTCTCCAACAGCAAGAATCTTTTGTTTTCATTTTGCACGTGACCTTAT
CTTGGAAACTCTTATACCCAATTGCCTCCCCTCCTATTATTCAGAGCTTCCCTGTCTTTTTACTTGAAGACAAATAAGTTTGAGCACTTG
AGTAAAACTTCACAGGTGTGTAAGTAGGAAGGCAACATTTTCAAAAAGAGACCATATGATGAGAACGCCTAATGATCACCACATGCAAAC
AAACAAAACTGCCAGTCTCATTTCCCACATTTCTTACTTAAGAGAAGAGAAGTAAATGAAAGGAAGAAGAAATAGATTTGTAATTAAAGA
TGTGGCAAAAAAGATAGGGCTGAGCCAGTTCAATTTAGCCTTCAGGTGCAGAATACTTAGAGTCCAAAGAAATGTGGAGTGGACTTAATT
AGATGCAGTTGTCTTTATCCTGAAAGTAGTGAGCTAAGCCTAATTTCCAGCATTTTGAAAGAGATTCCTTTTTGTTTCTTTCCATGGTGC
CCTCTTTAAGGCACAGAGTTGCTCCACACCACTGGGTGGAGAAAGAAAGATTGCGAACCCTCGACCATCCTTTTGAGGCTACATTCTATG
TTATTTGGCAGATTTATAAAGCTATCAGTAATAACAATGCTATGTACTGCAAGCTGCCCTTGTGTTAGTTAAAGGGAGCATTTTTAATCG
TTCGGAAATTTTCGTGACATGTCAAGTGCAGTTGTGAGGACTGTGTGGGTGAACGAAAATGTGTCTGTCAAGTTCAGAGTCCTTTAGATT
TAAAAAAAAATTATGACTTATCAATGGTGCCGTTATAGCTGTGTCAGACAATGGGTGTGCCCATTCTCACAATTATCCTTCAAAAAAAAT
CTATGTTCAAATGCTTTAAAAATTTATCACACGATACAAGAGTATGACTTTGTCAGCCTTCTAGAGTTCTTTTTTTCTTTTATTTTCTTT
CGTATTTTTTCCTTCAAAAAATCAATGAAGACTTGATTTCTGTCAATAATTGTATCAAGGGTGAATATACTACCTGAATTTTGTGCATGT
TACATTGTAGTTGTAACCTTTTCTAATTCAGGATGAATACGAGATGGTTGTGATTGTGCAGTGTACCAATAAAGTTCGAGAAATTTGTAA

>92126_92126_2_TMEM45B-OPCML_TMEM45B_chr11_129724711_ENST00000524567_OPCML_chr11_132307253_ENST00000524381_length(amino acids)=299AA_BP=124
MMANFKGHALPGSFFLIIGLCWSVKYPLKYFSHTRKNSPLHYYQRLEIVEAAIRTLFSVTGILAEQFVPDGPHLHLYHENHWIKLMNWQH
STMYLFFAVSGIVDMLTYLVSHVPLGVDRLVMAVAVFMEEGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYI
SKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGPGA

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Fusion Gene PPI Analysis for TMEM45B-OPCML

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TMEM45B-OPCML

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TMEM45B-OPCML

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source