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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMEM64-HHLA1 (FusionGDB2 ID:92217)

Fusion Gene Summary for TMEM64-HHLA1

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM64-HHLA1
	Fusion gene ID: 92217
		Hgene	Tgene
	Gene symbol	TMEM64	HHLA1
	Gene ID	169200	10086
	Gene name	transmembrane protein 64	HERV-H LTR-associating 1
	Synonyms	-	PLA2L
	Cytomap	8q21.3	8q24.22
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 64	HERV-H LTR-associating protein 1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000418210, ENST00000458549, ENST00000519519, ENST00000523902,	ENST00000434736, ENST00000414222,
Fusion gene scores	* DoF score	5 X 3 X 3=45	3 X 4 X 1=12
	# samples	4	4
	** MAII score	log2(4/45*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: TMEM64 [Title/Abstract] AND HHLA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM64(91657339)-HHLA1(133078215), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TMEM64 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HHLA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-62-A46S-01A	TMEM64	chr8	91657339	-	HHLA1	chr8	133076285	-
ChimerDB4	LUAD	TCGA-62-A46S-01A	TMEM64	chr8	91657339	-	HHLA1	chr8	133078215	-

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Fusion Gene ORF analysis for TMEM64-HHLA1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000418210	ENST00000434736	TMEM64	chr8	91657339	-	HHLA1	chr8	133076285	-
5CDS-intron	ENST00000418210	ENST00000434736	TMEM64	chr8	91657339	-	HHLA1	chr8	133078215	-
5CDS-intron	ENST00000458549	ENST00000434736	TMEM64	chr8	91657339	-	HHLA1	chr8	133076285	-
5CDS-intron	ENST00000458549	ENST00000434736	TMEM64	chr8	91657339	-	HHLA1	chr8	133078215	-
Frame-shift	ENST00000418210	ENST00000414222	TMEM64	chr8	91657339	-	HHLA1	chr8	133078215	-
Frame-shift	ENST00000458549	ENST00000414222	TMEM64	chr8	91657339	-	HHLA1	chr8	133078215	-
In-frame	ENST00000418210	ENST00000414222	TMEM64	chr8	91657339	-	HHLA1	chr8	133076285	-
In-frame	ENST00000458549	ENST00000414222	TMEM64	chr8	91657339	-	HHLA1	chr8	133076285	-
intron-3CDS	ENST00000519519	ENST00000414222	TMEM64	chr8	91657339	-	HHLA1	chr8	133076285	-
intron-3CDS	ENST00000519519	ENST00000414222	TMEM64	chr8	91657339	-	HHLA1	chr8	133078215	-
intron-3CDS	ENST00000523902	ENST00000414222	TMEM64	chr8	91657339	-	HHLA1	chr8	133076285	-
intron-3CDS	ENST00000523902	ENST00000414222	TMEM64	chr8	91657339	-	HHLA1	chr8	133078215	-
intron-intron	ENST00000519519	ENST00000434736	TMEM64	chr8	91657339	-	HHLA1	chr8	133076285	-
intron-intron	ENST00000519519	ENST00000434736	TMEM64	chr8	91657339	-	HHLA1	chr8	133078215	-
intron-intron	ENST00000523902	ENST00000434736	TMEM64	chr8	91657339	-	HHLA1	chr8	133076285	-
intron-intron	ENST00000523902	ENST00000434736	TMEM64	chr8	91657339	-	HHLA1	chr8	133078215	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000418210	TMEM64	chr8	91657339	-	ENST00000414222	HHLA1	chr8	133076285	-	3348	795	0	800	266
ENST00000458549	TMEM64	chr8	91657339	-	ENST00000414222	HHLA1	chr8	133076285	-	3526	973	957	121	278

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000418210	ENST00000414222	TMEM64	chr8	91657339	-	HHLA1	chr8	133076285	-	0.06833151	0.9316685
ENST00000458549	ENST00000414222	TMEM64	chr8	91657339	-	HHLA1	chr8	133076285	-	0.075915895	0.92408407

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Fusion Genomic Features for TMEM64-HHLA1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM64-HHLA1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:91657339/chr8:133078215)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000418210

120_140

265

329.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000418210

160_180

265

329.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000418210

188_208

265

329.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000418210

50_70

265

329.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000418210

84_104

265

329.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000458549

120_140

265

381.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000458549

160_180

265

381.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000458549

188_208

265

381.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000458549

50_70

265

381.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000458549

84_104

265

381.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000418210

186_296

265

329.0

Region

VTT domain

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000458549

186_296

265

381.0

Region

VTT domain

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000519519

186_296

120.0

Region

VTT domain

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000418210

308_328

265

329.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000458549

308_328

265

381.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000519519

120_140

120.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000519519

160_180

120.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000519519

188_208

120.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000519519

308_328

120.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000519519

50_70

120.0

Transmembrane

Helical

Hgene

TMEM64

chr8:91657339

chr8:133076285

ENST00000519519

84_104

120.0

Transmembrane

Helical

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Fusion Gene Sequence for TMEM64-HHLA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>92217_92217_1_TMEM64-HHLA1_TMEM64_chr8_91657339_ENST00000418210_HHLA1_chr8_133076285_ENST00000414222_length(transcript)=3348nt_BP=795nt
ATGCGGAGCCCGGGCGGGATCCTGCTCCAGGCGCTGCCCCGGCTGCTGCAGCACGCCGCCCTCCCGGGCCTCGCCGAGCTGCCGGCCCGC
TGGGCCCTGCCGCGGGGTGCGGGCGGGGACGGCCCGGCGGACCGCCTTCCCCGCGGGGGCGGGGCGAGCGCGGCGGCGGCAGCAGCGGCG
GCCTCGGGCGCCCTGCTCGGCGCCTATCTGGAGCGCCACGGTCCGCCCGAGGCTTCGGAGCTGCCGGAGCCGGGCGGGGCCTTGGCGGGC
GGCCCCGGGAGTGGCGGCGGCGGCGTGGTGGTCGGCGTGGCTGAGGTGAGAAACTGGCGCTGCTGCTGCCTCGGCAGCACCTGTTGGTGC
CGGAGCCTCGTGCTGGTCTGCGTGTTGGCCGCCCTGTGCTTCGCTTCCCTGGCCCTGGTCCGCCGCTACCTTCACCACCTCCTGCTGTGG
GTGGAGAGCCTTGACTCGCTGCTGGGGGTCCTGCTCTTCGTCGTGGGCTTCATCGTGGTCTCTTTCCCCTGCGGCTGGGGCTACATCGTG
CTCAACGTGGCCGCTGGCTACCTGTACGGCTTCGTGCTGGGCATGGGTCTGATGATGGTGGGCGTCCTCATCGGCACCTTCATCGCCCAT
GTGGTCTGCAAGCGGCTCCTCACCGCCTGGGTGGCCGCCAGGATCCAGAGCAGCGAGAAGCTGAGCGCGGTTATTCGCGTAGTGGAGGGA
GGAAGCGGCCTGAAAGTGGTGGCGCTGGCCAGACTGACACCCATACCTTTTGGGCTTCAGAATGCAGTGTTTTCGCCTTAAAGCAAAAGT
GCCTTGAGAATATCTGCAAGTCTGTGTGAGGCCTTGAAAATAACACTAGGGCATAACAATTACTTCAGGGGATACGCCATCCACCCTGGC
TCTTGTCCCAAGTGGGCTACATTTGAAGAATTCACCCAGGCTCCAGCTAGATCATCAGTTAATTTAAAGTGGTTATTCTTGGAAGTAGCA
TTTTTTTTCCCTCTCCTGTGAATCTGTGCAAAACATTGAAGGTAGAAGTTTTCTTGTTAGAGGCCTCACAATTAATACAGTAATGCCAGA
CTCCTTGCCTGCTTCAAAATCATGGAAATCTAGTGTTCATGCTCAAGAAACTCCTACAATGCTTGAGGCAATCCTGACAATTTAAAAACT
GGGGATGCGTGGGCACTCTAGCCTGCACAAACCAGTTCAGCCATGGAGACTCTGACACAATACCTGAGGTGACTTAAACTTGAGACTTTT
GAAAGACAACAAAAGCATAAATTAATATTGAATTCATACTCTAGAGAGATTCACATATACTGATAGTTAACTAATACATGTACAACCAAT
CAGACTTGCCATGGTATGGGATCTATATAATCTTCCAAGCCCCCTTAAGTGGGCGATAATGAAAACTTTATCATTAGGAGGAGGTTTAGA
GAGTTGTTTTTATTGACATCTTGTCTTGATTCCTCTTCTGTGTGACCCACTGGATTCAGAGGTCCCCATGAGCACCCTCAGGTTCAATGA
TTCATGAGTAGAACTCAGAGGTAGGGAAAACTGTTATATGCACATTTAGCATTTATTACAACAAAAGGATGCAGATGAAAAGCAGCAAAT
GTGAAAGGCACCTCTAGAGAGAGTCCAAGAGAGCCCAGGCACAAGCTTCCAGTGGGGTTGCACAGTCAGCATCTAATCCTCCCAGAAATA
ATGTTTAACAACACGTGGAGTATTGTCAGCCAGGAAAGCTCATCCAAGTTTTGGTGTCCAGGGGATGTTTGGGGGTATGGAGTAGGTATG
GAGTGCCTTCATGGCCTGCATGGCTAAACTTAGTTATTCAGTCTCCAGTCCCTCTAGAGGTCAAGCTGATACTGCACGACCTAAGGCCCC
ACCATAAATCACATTGTTAACATAAACTATCTGTCATGGCACGAAGCCCCAGGTACAAGAGACACTCATCAGGCAGGATATTCCAAGGAT
TTACAGGGGATTCCCCAGGAGCTGGTCAAGGACCAGATGTTCCTCTGAAAGGTGCAGGATTTGAGCTCATCTGTGGAGTACGTCTGTGGA
GTCAACTTTCTTCTGCATCCCCACATACTGATTTGCCACCTTCATTGTATCAGATTCCTTTTTCACTATATTCAGGTTTGCGGTTGCTCC
AGTATCCCTATCTATGCTGAGTCTCCACGTAGAGCATGTGTGCCCTCTCCAGTGGCTCTGCACGGACCCCTTATTTCTCATTACCAGGGA
CAGTTTTTCTCCTGATGTGCCTGGTGCTCCTTCTCCACTCTCTTGCCTTAGGACTCTGCTGGGCCATGAGTATTTTTTTTACCCTTTTGT
GACCTAGGGCTGCCCTTGGGTGAGGAAAGTCACTTTCTGTTCATCATCTAAGTAGAAAACAGTTTCTGCCATTGGAAGACCCCTGAGTTC
CCTGGCACTCCTGTGAACCACAAGGTGCCTGGGGAGGTAGAACTTGGACATTGGAGAGAGGAGCAGCCAGACATTTCTCTTTCTAATCAT
ATGCAGAAAGATTTCTTTTTATTCTCCAGAACACTTGAAAGACTCTCCAAGTTATGCAAATGTCAAGCTCATAAATGTATATTATCATGA
CTTTTGCAAAGATGAAGAGGATACAGCAAATTTTCTGGGAGGCAAAGGGACTTCTACCTGGATAGGAACCAAGCAAACTCATTAAGCATG
GATTAATTTGATTCAACCCTTGCGTGGATATTAATTAAGGACCTTTGACAGGAGAGGGTCCTCAAGGTTCCTCAAAGAGTAACTTATCAT
CAAGGAAGGTGAAGAATGGATGGATGGCTTGGGCCCAAGACTGGGGCTATTCACTTGTGGGGAAACCCATGTGAACCCAGTTACCCCATA
CTTTGGGAATAATGACTGAGCATGACTATAATCTTTAAGAAGCTCAAATGCGGAATACCTCTGAGGCTTATGCAAGGATCTGGCCTAGCA
TCAAGGACAAAGGCTCAGAGGACTCCTTGGGGCCAGTTTTCTACAGTCATACCATCAGCCACAACAGCAGCAAAGGCAGAAGGAAAACAG
GGCCCAGGAGTGGCTGACGACTGCCTGGAGTCCAACTGGTCTCCTGGAGTTCATAAGAGGTTTGACCCCTTCTGAGCTGAATGTGTCCTG
ATTTAGGGGATAGCTAGGGCAATAAGAAAGCCTCAGGGGGTGCTACTGATCTGGAACTCCTACTAATTAGTGTGTATGTATGTGGCCACC
AGTGGTTAGCAGATGAGGTGAAAGAGATGGGACAGTGACTGTATCTGTTCTGATGAAGGAGATTGTGCAGTTACATGCGTAACGTCATTA

>92217_92217_1_TMEM64-HHLA1_TMEM64_chr8_91657339_ENST00000418210_HHLA1_chr8_133076285_ENST00000414222_length(amino acids)=266AA_BP=
MRSPGGILLQALPRLLQHAALPGLAELPARWALPRGAGGDGPADRLPRGGGASAAAAAAAASGALLGAYLERHGPPEASELPEPGGALAG
GPGSGGGGVVVGVAEVRNWRCCCLGSTCWCRSLVLVCVLAALCFASLALVRRYLHHLLLWVESLDSLLGVLLFVVGFIVVSFPCGWGYIV

--------------------------------------------------------------
>92217_92217_2_TMEM64-HHLA1_TMEM64_chr8_91657339_ENST00000458549_HHLA1_chr8_133076285_ENST00000414222_length(transcript)=3526nt_BP=973nt
ACTCCCCGCCTGGCCGTCGCTCCTCCGCTGACTCCGCGCCCTTCTACGGGCCGTCTCCCACCCTCTGAGCGGACGCAGGGAGTCGATGCC
GGGCGAACCGGGCGCCATGAAGGGCAGCTGCCTAACGGGCGCCGCGGCGGAGGGGCTGGCCGGCTGAGGGCCCGCGCTGGGCCGAGGCAT
GCGGAGCCCGGGCGGGATCCTGCTCCAGGCGCTGCCCCGGCTGCTGCAGCACGCCGCCCTCCCGGGCCTCGCCGAGCTGCCGGCCCGCTG
GGCCCTGCCGCGGGGTGCGGGCGGGGACGGCCCGGCGGACCGCCTTCCCCGCGGGGGCGGGGCGAGCGCGGCGGCGGCAGCAGCGGCGGC
CTCGGGCGCCCTGCTCGGCGCCTATCTGGAGCGCCACGGTCCGCCCGAGGCTTCGGAGCTGCCGGAGCCGGGCGGGGCCTTGGCGGGCGG
CCCCGGGAGTGGCGGCGGCGGCGTGGTGGTCGGCGTGGCTGAGGTGAGAAACTGGCGCTGCTGCTGCCTCGGCAGCACCTGTTGGTGCCG
GAGCCTCGTGCTGGTCTGCGTGTTGGCCGCCCTGTGCTTCGCTTCCCTGGCCCTGGTCCGCCGCTACCTTCACCACCTCCTGCTGTGGGT
GGAGAGCCTTGACTCGCTGCTGGGGGTCCTGCTCTTCGTCGTGGGCTTCATCGTGGTCTCTTTCCCCTGCGGCTGGGGCTACATCGTGCT
CAACGTGGCCGCTGGCTACCTGTACGGCTTCGTGCTGGGCATGGGTCTGATGATGGTGGGCGTCCTCATCGGCACCTTCATCGCCCATGT
GGTCTGCAAGCGGCTCCTCACCGCCTGGGTGGCCGCCAGGATCCAGAGCAGCGAGAAGCTGAGCGCGGTTATTCGCGTAGTGGAGGGAGG
AAGCGGCCTGAAAGTGGTGGCGCTGGCCAGACTGACACCCATACCTTTTGGGCTTCAGAATGCAGTGTTTTCGCCTTAAAGCAAAAGTGC
CTTGAGAATATCTGCAAGTCTGTGTGAGGCCTTGAAAATAACACTAGGGCATAACAATTACTTCAGGGGATACGCCATCCACCCTGGCTC
TTGTCCCAAGTGGGCTACATTTGAAGAATTCACCCAGGCTCCAGCTAGATCATCAGTTAATTTAAAGTGGTTATTCTTGGAAGTAGCATT
TTTTTTCCCTCTCCTGTGAATCTGTGCAAAACATTGAAGGTAGAAGTTTTCTTGTTAGAGGCCTCACAATTAATACAGTAATGCCAGACT
CCTTGCCTGCTTCAAAATCATGGAAATCTAGTGTTCATGCTCAAGAAACTCCTACAATGCTTGAGGCAATCCTGACAATTTAAAAACTGG
GGATGCGTGGGCACTCTAGCCTGCACAAACCAGTTCAGCCATGGAGACTCTGACACAATACCTGAGGTGACTTAAACTTGAGACTTTTGA
AAGACAACAAAAGCATAAATTAATATTGAATTCATACTCTAGAGAGATTCACATATACTGATAGTTAACTAATACATGTACAACCAATCA
GACTTGCCATGGTATGGGATCTATATAATCTTCCAAGCCCCCTTAAGTGGGCGATAATGAAAACTTTATCATTAGGAGGAGGTTTAGAGA
GTTGTTTTTATTGACATCTTGTCTTGATTCCTCTTCTGTGTGACCCACTGGATTCAGAGGTCCCCATGAGCACCCTCAGGTTCAATGATT
CATGAGTAGAACTCAGAGGTAGGGAAAACTGTTATATGCACATTTAGCATTTATTACAACAAAAGGATGCAGATGAAAAGCAGCAAATGT
GAAAGGCACCTCTAGAGAGAGTCCAAGAGAGCCCAGGCACAAGCTTCCAGTGGGGTTGCACAGTCAGCATCTAATCCTCCCAGAAATAAT
GTTTAACAACACGTGGAGTATTGTCAGCCAGGAAAGCTCATCCAAGTTTTGGTGTCCAGGGGATGTTTGGGGGTATGGAGTAGGTATGGA
GTGCCTTCATGGCCTGCATGGCTAAACTTAGTTATTCAGTCTCCAGTCCCTCTAGAGGTCAAGCTGATACTGCACGACCTAAGGCCCCAC
CATAAATCACATTGTTAACATAAACTATCTGTCATGGCACGAAGCCCCAGGTACAAGAGACACTCATCAGGCAGGATATTCCAAGGATTT
ACAGGGGATTCCCCAGGAGCTGGTCAAGGACCAGATGTTCCTCTGAAAGGTGCAGGATTTGAGCTCATCTGTGGAGTACGTCTGTGGAGT
CAACTTTCTTCTGCATCCCCACATACTGATTTGCCACCTTCATTGTATCAGATTCCTTTTTCACTATATTCAGGTTTGCGGTTGCTCCAG
TATCCCTATCTATGCTGAGTCTCCACGTAGAGCATGTGTGCCCTCTCCAGTGGCTCTGCACGGACCCCTTATTTCTCATTACCAGGGACA
GTTTTTCTCCTGATGTGCCTGGTGCTCCTTCTCCACTCTCTTGCCTTAGGACTCTGCTGGGCCATGAGTATTTTTTTTACCCTTTTGTGA
CCTAGGGCTGCCCTTGGGTGAGGAAAGTCACTTTCTGTTCATCATCTAAGTAGAAAACAGTTTCTGCCATTGGAAGACCCCTGAGTTCCC
TGGCACTCCTGTGAACCACAAGGTGCCTGGGGAGGTAGAACTTGGACATTGGAGAGAGGAGCAGCCAGACATTTCTCTTTCTAATCATAT
GCAGAAAGATTTCTTTTTATTCTCCAGAACACTTGAAAGACTCTCCAAGTTATGCAAATGTCAAGCTCATAAATGTATATTATCATGACT
TTTGCAAAGATGAAGAGGATACAGCAAATTTTCTGGGAGGCAAAGGGACTTCTACCTGGATAGGAACCAAGCAAACTCATTAAGCATGGA
TTAATTTGATTCAACCCTTGCGTGGATATTAATTAAGGACCTTTGACAGGAGAGGGTCCTCAAGGTTCCTCAAAGAGTAACTTATCATCA
AGGAAGGTGAAGAATGGATGGATGGCTTGGGCCCAAGACTGGGGCTATTCACTTGTGGGGAAACCCATGTGAACCCAGTTACCCCATACT
TTGGGAATAATGACTGAGCATGACTATAATCTTTAAGAAGCTCAAATGCGGAATACCTCTGAGGCTTATGCAAGGATCTGGCCTAGCATC
AAGGACAAAGGCTCAGAGGACTCCTTGGGGCCAGTTTTCTACAGTCATACCATCAGCCACAACAGCAGCAAAGGCAGAAGGAAAACAGGG
CCCAGGAGTGGCTGACGACTGCCTGGAGTCCAACTGGTCTCCTGGAGTTCATAAGAGGTTTGACCCCTTCTGAGCTGAATGTGTCCTGAT
TTAGGGGATAGCTAGGGCAATAAGAAAGCCTCAGGGGGTGCTACTGATCTGGAACTCCTACTAATTAGTGTGTATGTATGTGGCCACCAG
TGGTTAGCAGATGAGGTGAAAGAGATGGGACAGTGACTGTATCTGTTCTGATGAAGGAGATTGTGCAGTTACATGCGTAACGTCATTAAA

>92217_92217_2_TMEM64-HHLA1_TMEM64_chr8_91657339_ENST00000458549_HHLA1_chr8_133076285_ENST00000414222_length(amino acids)=278AA_BP=
MKPKRYGCQSGQRHHFQAASSLHYANNRAQLLAALDPGGHPGGEEPLADHMGDEGADEDAHHHQTHAQHEAVQVASGHVEHDVAPAAGER
DHDEAHDEEQDPQQRVKALHPQQEVVKVAADQGQGSEAQGGQHADQHEAPAPTGAAEAAAAPVSHLSHADHHAAAATPGAARQGPARLRQ
LRSLGRTVALQIGAEQGARGRRCCRRRARPAPAGKAVRRAVPARTPRQGPAGRQLGEAREGGVLQQPGQRLEQDPARAPHASAQRGPSAG

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Fusion Gene PPI Analysis for TMEM64-HHLA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TMEM64-HHLA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TMEM64-HHLA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source