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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM64-NECAB1 (FusionGDB2 ID:92219)

Fusion Gene Summary for TMEM64-NECAB1

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM64-NECAB1
Fusion gene ID: 92219
HgeneTgene
Gene symbol

TMEM64

NECAB1

Gene ID

169200

64168

Gene nametransmembrane protein 64N-terminal EF-hand calcium binding protein 1
Synonyms-EFCBP1|STIP-1
Cytomap

8q21.3

8q21.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 64N-terminal EF-hand calcium-binding protein 1EF-hand calcium-binding protein 1neuronal calcium binding proteinneuronal calcium-binding protein 1synaptotagmin interacting protein 1
Modification date2020031320200313
UniProtAcc.

Q8N987

Ensembl transtripts involved in fusion geneENST00000418210, ENST00000458549, 
ENST00000519519, ENST00000523902, 
ENST00000521954, ENST00000521366, 
ENST00000522820, ENST00000417640, 
Fusion gene scores* DoF score5 X 3 X 3=456 X 3 X 4=72
# samples 46
** MAII scorelog2(4/45*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM64 [Title/Abstract] AND NECAB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM64(91657339)-NECAB1(91813919), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMEM64 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NECAB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0CZ-01ATMEM64chr8

91657339

-NECAB1chr8

91813919

+


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Fusion Gene ORF analysis for TMEM64-NECAB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000418210ENST00000521954TMEM64chr8

91657339

-NECAB1chr8

91813919

+
5CDS-3UTRENST00000458549ENST00000521954TMEM64chr8

91657339

-NECAB1chr8

91813919

+
5CDS-intronENST00000418210ENST00000521366TMEM64chr8

91657339

-NECAB1chr8

91813919

+
5CDS-intronENST00000418210ENST00000522820TMEM64chr8

91657339

-NECAB1chr8

91813919

+
5CDS-intronENST00000458549ENST00000521366TMEM64chr8

91657339

-NECAB1chr8

91813919

+
5CDS-intronENST00000458549ENST00000522820TMEM64chr8

91657339

-NECAB1chr8

91813919

+
In-frameENST00000418210ENST00000417640TMEM64chr8

91657339

-NECAB1chr8

91813919

+
In-frameENST00000458549ENST00000417640TMEM64chr8

91657339

-NECAB1chr8

91813919

+
intron-3CDSENST00000519519ENST00000417640TMEM64chr8

91657339

-NECAB1chr8

91813919

+
intron-3CDSENST00000523902ENST00000417640TMEM64chr8

91657339

-NECAB1chr8

91813919

+
intron-3UTRENST00000519519ENST00000521954TMEM64chr8

91657339

-NECAB1chr8

91813919

+
intron-3UTRENST00000523902ENST00000521954TMEM64chr8

91657339

-NECAB1chr8

91813919

+
intron-intronENST00000519519ENST00000521366TMEM64chr8

91657339

-NECAB1chr8

91813919

+
intron-intronENST00000519519ENST00000522820TMEM64chr8

91657339

-NECAB1chr8

91813919

+
intron-intronENST00000523902ENST00000521366TMEM64chr8

91657339

-NECAB1chr8

91813919

+
intron-intronENST00000523902ENST00000522820TMEM64chr8

91657339

-NECAB1chr8

91813919

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000418210TMEM64chr891657339-ENST00000417640NECAB1chr891813919+564879501751583
ENST00000458549TMEM64chr891657339-ENST00000417640NECAB1chr891813919+58269731661929587

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000418210ENST00000417640TMEM64chr891657339-NECAB1chr891813919+0.0002606020.99973935
ENST00000458549ENST00000417640TMEM64chr891657339-NECAB1chr891813919+0.0002863490.9997136

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Fusion Genomic Features for TMEM64-NECAB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMEM64chr891657338-NECAB1chr891813918+0.0023332190.99766684
TMEM64chr891657338-NECAB1chr891813918+0.0023332190.99766684

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TMEM64-NECAB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:91657339/chr8:91813919)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NECAB1

Q8N987

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM64chr8:91657339chr8:91813919ENST00000418210-12120_140265329.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000418210-12160_180265329.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000418210-12188_208265329.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000418210-1250_70265329.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000418210-1284_104265329.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000458549-13120_140265381.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000458549-13160_180265381.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000458549-13188_208265381.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000458549-1350_70265381.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000458549-1384_104265381.0TransmembraneHelical
TgeneNECAB1chr8:91657339chr8:91813919ENST0000041764001339_5033352.0Calcium binding1
TgeneNECAB1chr8:91657339chr8:91813919ENST000005213660439_500101.0Calcium binding1
TgeneNECAB1chr8:91657339chr8:91813919ENST000005228200539_500101.0Calcium binding1
TgeneNECAB1chr8:91657339chr8:91813919ENST00000417640013135_16333352.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:91657339chr8:91813919ENST00000417640013209_27533352.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:91657339chr8:91813919ENST0000052136604135_1630101.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:91657339chr8:91813919ENST0000052136604209_2750101.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:91657339chr8:91813919ENST0000052282005135_1630101.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:91657339chr8:91813919ENST0000052282005209_2750101.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:91657339chr8:91813919ENST00000417640013252_34033352.0DomainNote=ABM
TgeneNECAB1chr8:91657339chr8:91813919ENST0000041764001360_9533352.0DomainEF-hand 2
TgeneNECAB1chr8:91657339chr8:91813919ENST0000052136604252_3400101.0DomainNote=ABM
TgeneNECAB1chr8:91657339chr8:91813919ENST000005213660426_610101.0DomainEF-hand 1
TgeneNECAB1chr8:91657339chr8:91813919ENST000005213660460_950101.0DomainEF-hand 2
TgeneNECAB1chr8:91657339chr8:91813919ENST0000052282005252_3400101.0DomainNote=ABM
TgeneNECAB1chr8:91657339chr8:91813919ENST000005228200526_610101.0DomainEF-hand 1
TgeneNECAB1chr8:91657339chr8:91813919ENST000005228200560_950101.0DomainEF-hand 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM64chr8:91657339chr8:91813919ENST00000418210-12186_296265329.0RegionVTT domain
HgeneTMEM64chr8:91657339chr8:91813919ENST00000458549-13186_296265381.0RegionVTT domain
HgeneTMEM64chr8:91657339chr8:91813919ENST00000519519-16186_2960120.0RegionVTT domain
HgeneTMEM64chr8:91657339chr8:91813919ENST00000418210-12308_328265329.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000458549-13308_328265381.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000519519-16120_1400120.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000519519-16160_1800120.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000519519-16188_2080120.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000519519-16308_3280120.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000519519-1650_700120.0TransmembraneHelical
HgeneTMEM64chr8:91657339chr8:91813919ENST00000519519-1684_1040120.0TransmembraneHelical
TgeneNECAB1chr8:91657339chr8:91813919ENST0000041764001326_6133352.0DomainEF-hand 1


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Fusion Gene Sequence for TMEM64-NECAB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92219_92219_1_TMEM64-NECAB1_TMEM64_chr8_91657339_ENST00000418210_NECAB1_chr8_91813919_ENST00000417640_length(transcript)=5648nt_BP=795nt
ATGCGGAGCCCGGGCGGGATCCTGCTCCAGGCGCTGCCCCGGCTGCTGCAGCACGCCGCCCTCCCGGGCCTCGCCGAGCTGCCGGCCCGC
TGGGCCCTGCCGCGGGGTGCGGGCGGGGACGGCCCGGCGGACCGCCTTCCCCGCGGGGGCGGGGCGAGCGCGGCGGCGGCAGCAGCGGCG
GCCTCGGGCGCCCTGCTCGGCGCCTATCTGGAGCGCCACGGTCCGCCCGAGGCTTCGGAGCTGCCGGAGCCGGGCGGGGCCTTGGCGGGC
GGCCCCGGGAGTGGCGGCGGCGGCGTGGTGGTCGGCGTGGCTGAGGTGAGAAACTGGCGCTGCTGCTGCCTCGGCAGCACCTGTTGGTGC
CGGAGCCTCGTGCTGGTCTGCGTGTTGGCCGCCCTGTGCTTCGCTTCCCTGGCCCTGGTCCGCCGCTACCTTCACCACCTCCTGCTGTGG
GTGGAGAGCCTTGACTCGCTGCTGGGGGTCCTGCTCTTCGTCGTGGGCTTCATCGTGGTCTCTTTCCCCTGCGGCTGGGGCTACATCGTG
CTCAACGTGGCCGCTGGCTACCTGTACGGCTTCGTGCTGGGCATGGGTCTGATGATGGTGGGCGTCCTCATCGGCACCTTCATCGCCCAT
GTGGTCTGCAAGCGGCTCCTCACCGCCTGGGTGGCCGCCAGGATCCAGAGCAGCGAGAAGCTGAGCGCGGTTATTCGCGTAGTGGAGGGA
GGAAGCGGCCTGAAAGTGGTGGCGCTGGCCAGACTGACACCCATACCTTTTGGGCTTCAGAATGCAGTGTTTTCGATACTGAGGAGAGCA
GACAAAAATGATGATGGAAAATTATCCTTTGAAGAATTCAAAGCATATTTTGCAGATGGTGTTCTCAGTGGAGAAGAATTACACGAGCTT
TTCCATACCATTGATACACATAATACTAATAATCTTGACACAGAAGAGCTATGTGAATATTTTTCTCAGCACTTGGGCGAGTATGAGAAT
GTACTAGCAGCACTTGAAGACCTGAATCTTTCCATCCTGAAGGCAATGGGCAAAACAAAGAAAGACTACCAAGAAGCCTCCAATTTGGAA
CAATTCGTAACTAGATTTTTATTGAAGGAAACCCTGAATCAGCTGCAGTCTCTCCAGAATTCCCTGGAATGTGCCATGGAAACTACTGAG
GAGCAAACCCGTCAAGAAAGGCAAGGGCCAGCCAAGCCAGAAGTCCTGTCGATTCAATGGCCTGGAAAACGATCAAGCCGCCGAGTCCAG
AGACACAACAGCTTCTCCCCAAACAGCCCTCAGTTTAATGTCAGCGGTCCAGGCTTATTAGAAGAAGACAACCAGTGGATGACCCAGATA
AATAGACTCCAGAAATTAATTGATAGACTGGAAAAGAAGGATCTCAAACTCGAACCACCAGAAGAAGAAATTATTGAAGGGAATACTAAA
TCTCACATCATGCTTGTGCAGCGGCAGATGTCTGTGATAGAAGAGGACCTGGAAGAATTCCAGCTCGCTCTGAAACACTACGTGGAGAGT
GCTTCCTCCCAAAGTGGATGCTTGCGTATTTCTATACAGAAGCTTTCAAATGAATCTCGCTACATGATCTATGAGTTCTGGGAGAATAGT
AGTGTATGGAATAGCCACCTTCAGACAAATTATAGCAAGACATTCCAAAGAAGTAATGTGGATTTCTTGGAAACTCCAGAACTCACATCT
ACAATGCTAGTTCCTGCTTCGTGGTGGATCCTGAACAACTAGATGTTCCTAGACATTTTCTTTATGGTTCCAAGTGCAAAACAGGTGTTC
TTATCTAAAACGTCAATTAGAAAATTATCTGCGGTTGTTAATCTACTGTATATTTTTGTTTGGTATATTTACTAAGTGCACTCTTTCAAA
ACTTATTCTATAACTTTATCAATTCATGTGAATTTTAGCTCAATTTTCAAAGTTCACTAATATTCTCAATATTTAATGCTAAATGCTTTG
CTACATTGTAACTCACCTAAAACCTTTTAGTGACAAAATCCTAATATGTGGAAAAAAGCATATGCATAAAGGAATAATATTGTGAAAATG
AATCTGTTATGATAAAGAAAAAATAAAGTGGAAACTTTTAGAGTATTACTTCATAGGGCAGATTTTGTAAACTGTCGTATACTGTAAAGG
GTTAAATCAGCGTTTTGTGATTTTTAAGTAACTGTGAGTGAAGTTTATTCTTCAACAATGTCTACTCCATCCCCAACCCAACTCACAGCC
CTATGACTACTATCTTTGCATTAGTTAAAAAGTTAGTATATAGGCATCAAACAACCTTGGCTGTAACCTATAGAATCTCTATCCACGTAT
CAGGTTATAGACTGGTTTTTCAAAAGTGAACAATCCTGTGATAAGTTGGAGTACCATTTAGTAATACAGCAACATTGTGTCATTTATTAG
CATCATAATTCTTTGTTATGTAAGTTAAATATATCAAGAAAGAAGAGACTGTTTGGAAAAATGTGGTTCAAGTTTTATGCTATATAGTTT
TGGTATGCGATACAGACAGCTAACTTTTCTTATGAAAAATACATATTTGCATGTAAACAATGATTTCAAAATACTTGAAAAATAAAATTT
TAACCCAAATGAATAACTAAGAAATATAAAACAAGCACAAAATCTTAGGGAAGTCATAAAATAGTAGTGAAAGTATTAGACAGAAGACAT
CTGTTTTCGAATTTCAACACTAGAATGACTAAAACTATCTACCTATAGAACTATCTGTAGATAGTATACTATCTACACTCTGCTCAACAA
GCTCAGAAATTAAATATTTTTAATAATAAAAATCTGTTCTGGTTATAAACCTTGCTAATGAAAATACAATACATATAAAAATGTATAGCC
ATGTTATTTTCTAGTATAAATTCCTTTGAAACTATAAGTCTTTGAGGAAAATTATAAGGTAAAATTTTCCTGTTTTTCCCCCTTTGAAAA
ACTCAGGAAAAAAGGAAGATTGAACTAATAAAATTTTATTTCTTAAATATAAATTTGACCTAAAATATTTTCTCAAACTAATTCATGAAA
CAGCAACTTTTACCAATACCTTTGTATACTCTCAGTTCTCATTCAGTATAAATAAAATTTTAAAATCCTTTCATAGTTCTATTAGAAATA
AGTAGTAAATTTTGATATATTGTACATACACACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGTGTGCCTCTG
GTCAACTCTAAGGATGACAGACACTGTGTAACAACACCTGGGTCAACTCTTTTAATTTATATACAAAGCAAAGAACAACATTAATGGAGA
TGCACAATGATTATTCAAACAAGCTATATATATGTACAAAGGCAAACAGACACATAACAGTCTCTGCAGACTGATTGTATATAGTAAGAA
AAGATCAAAAGACTTTAAAACCTAAATGACTTTTGACATACAAACTCTTCTTGAGAATGTTTGTTGTAAATGGTTTCAAAAATACAAATT
ATAGCCAATCAAAACATTGCTTTGGTTGGTGCATTTAAGTATCCAACTCAAAAAGCATATCAAATATTTTGGGTACTAGGCAGTTTCCAA
AGTAGCATGGTAGTATTACTTGTTAAAAGGGTTCTGTTTTCATTAACAGTACTAAGTGGAAGGGATCTGCAGATTCCAAACTGGAATAAG
CTCTATCATATTCTGAAACAAGAATTAGAATGACTTGAGAACGGGCAAATAACAAAGCAAACCAATATAATTATATGGTCATTCTGACCC
CAGCTCTTATACAAATTATACATGTATTTTTGTGTATGTTTGTGAGAGTTGTATGTATGTGAATGTGTGTGAGTGTGTATTCACATACAC
ATATATACTGGAACCTATAGTAGAAAAGGAAACTAGTAGGGCCAAAAAAAAAAAGAAAAAGAAAAAGAAAAAAGAAAAAAAAAGAAAAAA
CTGGGACCTAAGTATAAATATCTCATCCTAAAGTAAACAATAAGTTTATAGTTAACGAAGATTTTTTTCTATTTAAAACCCCATTTTCCT
AAAGAACAAAGTAGTAAAATAAAAAAAAATTTAAAAAATTAAAAAATAAAAAAAAGAGGTCACTAAAAGACCAAGATGGGAAACGTAACA
TGGAATACAAGCTTGAATCTGGGAAACAAGCTCAAAAAACAGTGAAAAAAAAAGTACTGGTTTAGGAGTTCAAAATTCAGTGAAACAAAC
TTTTTGCCAATAGACCTAGGGATCTAAGAAATAGAATTAGGGAGAGTTTACACTTACTTACCTATATATCAGCAGATTTTTCTGGAAGAA
ACCCTTTTTTTTTTTTTTTTTAAACAGTAACATCCAGAGTGACAAATTGCAGGAGATTTAATGTATAAAATTTCTAGGAATTAAAAGCTT
AAACCCAAAAATTGTTCATCCATATATAAGAAATTATCGAATTAAAACTTAATGTATGTCAATTATTTTCAAATGTCTAAATTCCTTTGG
AAATAAAAATATCAGTTTTACTTTGAAATTGCTCAACTTCTGCTATTCATATGGTCTGATTAGTGACATAAGTAGCAGCCGTTTTTCAAC
TTCAGTTTCATTCACTACCATTGTTTCCAAATTATCAATCTCTGCTAGTAATTATGAATTTAAGACCATATTATTATCAAAAACCTAGAG
ACCAATCATATATCTGAAAAGAAATACCCATTAAAAATTCTGCCTCCTGTTTATTGAGAACTATGCATTGAACATTCTGAATCATTCTAA
GCCTCTGGAGAGACTGTAATGATCCATTCATGAGCTGGTATGAAATCAGTGGGAAGCAGAACAACAGAAGGAACTTTAAAAGCAACAAGC
AATTATGTACCATATATACACTGTAGCAAATATTTTATATTTGAGAGTCTTTACAGCTTACATTTCCATTCCATTATTACAAGTGATGAA
AAACAAAAAATTGCAAGTAGTATGCAAATTATAAATATACAGTCTTCCCACTTCACTAACCAAATTCCTACTTTCCAGTGTTACTTCCCA
ATTTATGCAGGAAACCTCCTGCAAAGCTGAAACTGATTAGAAAATTCTTTATATTTTAAAATAGCTCTTTCTCATTTTTAGAGAAGTCAA
ATAGCCAACCATCAAAATTAAGAATAAATTGAATTGTCACAGTCCATTACAGTTATTGTTGCTAGATCCACCTCATTTGCAGATGTCCAA
ACTTAAATTCATCTGTTCTTAAAATGCTACTTAAAACTTTGGTTGTTTTCCTGTAATATAAAAGAAAAAGTTAATTTATCAATTGATTGA
ATACAGTTTTTACTAATTAGTTTATCAAACCAAATACTGTGAACGTACCAGGTGTTTACAGATTTAAATGCATGTTACCATAGAAACTAT
TAAAGTAACTAGAACTGTCAAATAACAAAACGGCTCATGTTTTTAAAATATATGTAACTCATTTTAAAATATATTAAATTGTATTCCAAA
CCTGTTCTTCTGTTTCTGTGGCACCTAGGTTTAAAATATGTATTAATGTGTAAATCACAAGTAAAATGAATTCTAATGTACAAGTTTGTT

>92219_92219_1_TMEM64-NECAB1_TMEM64_chr8_91657339_ENST00000418210_NECAB1_chr8_91813919_ENST00000417640_length(amino acids)=583AA_BP=263
MRSPGGILLQALPRLLQHAALPGLAELPARWALPRGAGGDGPADRLPRGGGASAAAAAAAASGALLGAYLERHGPPEASELPEPGGALAG
GPGSGGGGVVVGVAEVRNWRCCCLGSTCWCRSLVLVCVLAALCFASLALVRRYLHHLLLWVESLDSLLGVLLFVVGFIVVSFPCGWGYIV
LNVAAGYLYGFVLGMGLMMVGVLIGTFIAHVVCKRLLTAWVAARIQSSEKLSAVIRVVEGGSGLKVVALARLTPIPFGLQNAVFSILRRA
DKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTHNTNNLDTEELCEYFSQHLGEYENVLAALEDLNLSILKAMGKTKKDYQEASNLE
QFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPAKPEVLSIQWPGKRSSRRVQRHNSFSPNSPQFNVSGPGLLEEDNQWMTQI
NRLQKLIDRLEKKDLKLEPPEEEIIEGNTKSHIMLVQRQMSVIEEDLEEFQLALKHYVESASSQSGCLRISIQKLSNESRYMIYEFWENS

--------------------------------------------------------------
>92219_92219_2_TMEM64-NECAB1_TMEM64_chr8_91657339_ENST00000458549_NECAB1_chr8_91813919_ENST00000417640_length(transcript)=5826nt_BP=973nt
ACTCCCCGCCTGGCCGTCGCTCCTCCGCTGACTCCGCGCCCTTCTACGGGCCGTCTCCCACCCTCTGAGCGGACGCAGGGAGTCGATGCC
GGGCGAACCGGGCGCCATGAAGGGCAGCTGCCTAACGGGCGCCGCGGCGGAGGGGCTGGCCGGCTGAGGGCCCGCGCTGGGCCGAGGCAT
GCGGAGCCCGGGCGGGATCCTGCTCCAGGCGCTGCCCCGGCTGCTGCAGCACGCCGCCCTCCCGGGCCTCGCCGAGCTGCCGGCCCGCTG
GGCCCTGCCGCGGGGTGCGGGCGGGGACGGCCCGGCGGACCGCCTTCCCCGCGGGGGCGGGGCGAGCGCGGCGGCGGCAGCAGCGGCGGC
CTCGGGCGCCCTGCTCGGCGCCTATCTGGAGCGCCACGGTCCGCCCGAGGCTTCGGAGCTGCCGGAGCCGGGCGGGGCCTTGGCGGGCGG
CCCCGGGAGTGGCGGCGGCGGCGTGGTGGTCGGCGTGGCTGAGGTGAGAAACTGGCGCTGCTGCTGCCTCGGCAGCACCTGTTGGTGCCG
GAGCCTCGTGCTGGTCTGCGTGTTGGCCGCCCTGTGCTTCGCTTCCCTGGCCCTGGTCCGCCGCTACCTTCACCACCTCCTGCTGTGGGT
GGAGAGCCTTGACTCGCTGCTGGGGGTCCTGCTCTTCGTCGTGGGCTTCATCGTGGTCTCTTTCCCCTGCGGCTGGGGCTACATCGTGCT
CAACGTGGCCGCTGGCTACCTGTACGGCTTCGTGCTGGGCATGGGTCTGATGATGGTGGGCGTCCTCATCGGCACCTTCATCGCCCATGT
GGTCTGCAAGCGGCTCCTCACCGCCTGGGTGGCCGCCAGGATCCAGAGCAGCGAGAAGCTGAGCGCGGTTATTCGCGTAGTGGAGGGAGG
AAGCGGCCTGAAAGTGGTGGCGCTGGCCAGACTGACACCCATACCTTTTGGGCTTCAGAATGCAGTGTTTTCGATACTGAGGAGAGCAGA
CAAAAATGATGATGGAAAATTATCCTTTGAAGAATTCAAAGCATATTTTGCAGATGGTGTTCTCAGTGGAGAAGAATTACACGAGCTTTT
CCATACCATTGATACACATAATACTAATAATCTTGACACAGAAGAGCTATGTGAATATTTTTCTCAGCACTTGGGCGAGTATGAGAATGT
ACTAGCAGCACTTGAAGACCTGAATCTTTCCATCCTGAAGGCAATGGGCAAAACAAAGAAAGACTACCAAGAAGCCTCCAATTTGGAACA
ATTCGTAACTAGATTTTTATTGAAGGAAACCCTGAATCAGCTGCAGTCTCTCCAGAATTCCCTGGAATGTGCCATGGAAACTACTGAGGA
GCAAACCCGTCAAGAAAGGCAAGGGCCAGCCAAGCCAGAAGTCCTGTCGATTCAATGGCCTGGAAAACGATCAAGCCGCCGAGTCCAGAG
ACACAACAGCTTCTCCCCAAACAGCCCTCAGTTTAATGTCAGCGGTCCAGGCTTATTAGAAGAAGACAACCAGTGGATGACCCAGATAAA
TAGACTCCAGAAATTAATTGATAGACTGGAAAAGAAGGATCTCAAACTCGAACCACCAGAAGAAGAAATTATTGAAGGGAATACTAAATC
TCACATCATGCTTGTGCAGCGGCAGATGTCTGTGATAGAAGAGGACCTGGAAGAATTCCAGCTCGCTCTGAAACACTACGTGGAGAGTGC
TTCCTCCCAAAGTGGATGCTTGCGTATTTCTATACAGAAGCTTTCAAATGAATCTCGCTACATGATCTATGAGTTCTGGGAGAATAGTAG
TGTATGGAATAGCCACCTTCAGACAAATTATAGCAAGACATTCCAAAGAAGTAATGTGGATTTCTTGGAAACTCCAGAACTCACATCTAC
AATGCTAGTTCCTGCTTCGTGGTGGATCCTGAACAACTAGATGTTCCTAGACATTTTCTTTATGGTTCCAAGTGCAAAACAGGTGTTCTT
ATCTAAAACGTCAATTAGAAAATTATCTGCGGTTGTTAATCTACTGTATATTTTTGTTTGGTATATTTACTAAGTGCACTCTTTCAAAAC
TTATTCTATAACTTTATCAATTCATGTGAATTTTAGCTCAATTTTCAAAGTTCACTAATATTCTCAATATTTAATGCTAAATGCTTTGCT
ACATTGTAACTCACCTAAAACCTTTTAGTGACAAAATCCTAATATGTGGAAAAAAGCATATGCATAAAGGAATAATATTGTGAAAATGAA
TCTGTTATGATAAAGAAAAAATAAAGTGGAAACTTTTAGAGTATTACTTCATAGGGCAGATTTTGTAAACTGTCGTATACTGTAAAGGGT
TAAATCAGCGTTTTGTGATTTTTAAGTAACTGTGAGTGAAGTTTATTCTTCAACAATGTCTACTCCATCCCCAACCCAACTCACAGCCCT
ATGACTACTATCTTTGCATTAGTTAAAAAGTTAGTATATAGGCATCAAACAACCTTGGCTGTAACCTATAGAATCTCTATCCACGTATCA
GGTTATAGACTGGTTTTTCAAAAGTGAACAATCCTGTGATAAGTTGGAGTACCATTTAGTAATACAGCAACATTGTGTCATTTATTAGCA
TCATAATTCTTTGTTATGTAAGTTAAATATATCAAGAAAGAAGAGACTGTTTGGAAAAATGTGGTTCAAGTTTTATGCTATATAGTTTTG
GTATGCGATACAGACAGCTAACTTTTCTTATGAAAAATACATATTTGCATGTAAACAATGATTTCAAAATACTTGAAAAATAAAATTTTA
ACCCAAATGAATAACTAAGAAATATAAAACAAGCACAAAATCTTAGGGAAGTCATAAAATAGTAGTGAAAGTATTAGACAGAAGACATCT
GTTTTCGAATTTCAACACTAGAATGACTAAAACTATCTACCTATAGAACTATCTGTAGATAGTATACTATCTACACTCTGCTCAACAAGC
TCAGAAATTAAATATTTTTAATAATAAAAATCTGTTCTGGTTATAAACCTTGCTAATGAAAATACAATACATATAAAAATGTATAGCCAT
GTTATTTTCTAGTATAAATTCCTTTGAAACTATAAGTCTTTGAGGAAAATTATAAGGTAAAATTTTCCTGTTTTTCCCCCTTTGAAAAAC
TCAGGAAAAAAGGAAGATTGAACTAATAAAATTTTATTTCTTAAATATAAATTTGACCTAAAATATTTTCTCAAACTAATTCATGAAACA
GCAACTTTTACCAATACCTTTGTATACTCTCAGTTCTCATTCAGTATAAATAAAATTTTAAAATCCTTTCATAGTTCTATTAGAAATAAG
TAGTAAATTTTGATATATTGTACATACACACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGTGTGCCTCTGGT
CAACTCTAAGGATGACAGACACTGTGTAACAACACCTGGGTCAACTCTTTTAATTTATATACAAAGCAAAGAACAACATTAATGGAGATG
CACAATGATTATTCAAACAAGCTATATATATGTACAAAGGCAAACAGACACATAACAGTCTCTGCAGACTGATTGTATATAGTAAGAAAA
GATCAAAAGACTTTAAAACCTAAATGACTTTTGACATACAAACTCTTCTTGAGAATGTTTGTTGTAAATGGTTTCAAAAATACAAATTAT
AGCCAATCAAAACATTGCTTTGGTTGGTGCATTTAAGTATCCAACTCAAAAAGCATATCAAATATTTTGGGTACTAGGCAGTTTCCAAAG
TAGCATGGTAGTATTACTTGTTAAAAGGGTTCTGTTTTCATTAACAGTACTAAGTGGAAGGGATCTGCAGATTCCAAACTGGAATAAGCT
CTATCATATTCTGAAACAAGAATTAGAATGACTTGAGAACGGGCAAATAACAAAGCAAACCAATATAATTATATGGTCATTCTGACCCCA
GCTCTTATACAAATTATACATGTATTTTTGTGTATGTTTGTGAGAGTTGTATGTATGTGAATGTGTGTGAGTGTGTATTCACATACACAT
ATATACTGGAACCTATAGTAGAAAAGGAAACTAGTAGGGCCAAAAAAAAAAAGAAAAAGAAAAAGAAAAAAGAAAAAAAAAGAAAAAACT
GGGACCTAAGTATAAATATCTCATCCTAAAGTAAACAATAAGTTTATAGTTAACGAAGATTTTTTTCTATTTAAAACCCCATTTTCCTAA
AGAACAAAGTAGTAAAATAAAAAAAAATTTAAAAAATTAAAAAATAAAAAAAAGAGGTCACTAAAAGACCAAGATGGGAAACGTAACATG
GAATACAAGCTTGAATCTGGGAAACAAGCTCAAAAAACAGTGAAAAAAAAAGTACTGGTTTAGGAGTTCAAAATTCAGTGAAACAAACTT
TTTGCCAATAGACCTAGGGATCTAAGAAATAGAATTAGGGAGAGTTTACACTTACTTACCTATATATCAGCAGATTTTTCTGGAAGAAAC
CCTTTTTTTTTTTTTTTTTAAACAGTAACATCCAGAGTGACAAATTGCAGGAGATTTAATGTATAAAATTTCTAGGAATTAAAAGCTTAA
ACCCAAAAATTGTTCATCCATATATAAGAAATTATCGAATTAAAACTTAATGTATGTCAATTATTTTCAAATGTCTAAATTCCTTTGGAA
ATAAAAATATCAGTTTTACTTTGAAATTGCTCAACTTCTGCTATTCATATGGTCTGATTAGTGACATAAGTAGCAGCCGTTTTTCAACTT
CAGTTTCATTCACTACCATTGTTTCCAAATTATCAATCTCTGCTAGTAATTATGAATTTAAGACCATATTATTATCAAAAACCTAGAGAC
CAATCATATATCTGAAAAGAAATACCCATTAAAAATTCTGCCTCCTGTTTATTGAGAACTATGCATTGAACATTCTGAATCATTCTAAGC
CTCTGGAGAGACTGTAATGATCCATTCATGAGCTGGTATGAAATCAGTGGGAAGCAGAACAACAGAAGGAACTTTAAAAGCAACAAGCAA
TTATGTACCATATATACACTGTAGCAAATATTTTATATTTGAGAGTCTTTACAGCTTACATTTCCATTCCATTATTACAAGTGATGAAAA
ACAAAAAATTGCAAGTAGTATGCAAATTATAAATATACAGTCTTCCCACTTCACTAACCAAATTCCTACTTTCCAGTGTTACTTCCCAAT
TTATGCAGGAAACCTCCTGCAAAGCTGAAACTGATTAGAAAATTCTTTATATTTTAAAATAGCTCTTTCTCATTTTTAGAGAAGTCAAAT
AGCCAACCATCAAAATTAAGAATAAATTGAATTGTCACAGTCCATTACAGTTATTGTTGCTAGATCCACCTCATTTGCAGATGTCCAAAC
TTAAATTCATCTGTTCTTAAAATGCTACTTAAAACTTTGGTTGTTTTCCTGTAATATAAAAGAAAAAGTTAATTTATCAATTGATTGAAT
ACAGTTTTTACTAATTAGTTTATCAAACCAAATACTGTGAACGTACCAGGTGTTTACAGATTTAAATGCATGTTACCATAGAAACTATTA
AAGTAACTAGAACTGTCAAATAACAAAACGGCTCATGTTTTTAAAATATATGTAACTCATTTTAAAATATATTAAATTGTATTCCAAACC
TGTTCTTCTGTTTCTGTGGCACCTAGGTTTAAAATATGTATTAATGTGTAAATCACAAGTAAAATGAATTCTAATGTACAAGTTTGTTTT

>92219_92219_2_TMEM64-NECAB1_TMEM64_chr8_91657339_ENST00000458549_NECAB1_chr8_91813919_ENST00000417640_length(amino acids)=587AA_BP=267
MGRGMRSPGGILLQALPRLLQHAALPGLAELPARWALPRGAGGDGPADRLPRGGGASAAAAAAAASGALLGAYLERHGPPEASELPEPGG
ALAGGPGSGGGGVVVGVAEVRNWRCCCLGSTCWCRSLVLVCVLAALCFASLALVRRYLHHLLLWVESLDSLLGVLLFVVGFIVVSFPCGW
GYIVLNVAAGYLYGFVLGMGLMMVGVLIGTFIAHVVCKRLLTAWVAARIQSSEKLSAVIRVVEGGSGLKVVALARLTPIPFGLQNAVFSI
LRRADKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTHNTNNLDTEELCEYFSQHLGEYENVLAALEDLNLSILKAMGKTKKDYQEA
SNLEQFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPAKPEVLSIQWPGKRSSRRVQRHNSFSPNSPQFNVSGPGLLEEDNQW
MTQINRLQKLIDRLEKKDLKLEPPEEEIIEGNTKSHIMLVQRQMSVIEEDLEEFQLALKHYVESASSQSGCLRISIQKLSNESRYMIYEF

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Fusion Gene PPI Analysis for TMEM64-NECAB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM64-NECAB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM64-NECAB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource