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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMOD2-C15orf59 (FusionGDB2 ID:92326)

Fusion Gene Summary for TMOD2-C15orf59

check button Fusion gene summary
Fusion gene informationFusion gene name: TMOD2-C15orf59
Fusion gene ID: 92326
HgeneTgene
Gene symbol

TMOD2

C15orf59

Gene ID

29767

388135

Gene nametropomodulin 2inhibitory synaptic factor 1
SynonymsN-TMOD|NTMODC15orf59
Cytomap

15q21.2

15q24.1

Type of geneprotein-codingprotein-coding
Descriptiontropomodulin-2neuronal tropomodulintropomodulin 2 (neuronal)inhibitory synaptic factor 1UPF0583 protein C15orf59inhibitory synaptic protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000249700, ENST00000539962, 
ENST00000435126, 		ENST00000558834, 
ENST00000379822, ENST00000569673, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 1 X 2=6
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/6*10)=1.73696559416621
Context

PubMed: TMOD2 [Title/Abstract] AND C15orf59 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMOD2(52075025)-C15orf59(74032983), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMOD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C15orf59 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-A7TC-01ATMOD2chr15

52075025

-C15orf59chr15

74032983

-
ChimerDB4LGGTCGA-DU-A7TC-01ATMOD2chr15

52075025

+C15orf59chr15

74032983

-
ChimerDB4LGGTCGA-DU-A7TCTMOD2chr15

52075025

+C15orf59chr15

74032983

-


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Fusion Gene ORF analysis for TMOD2-C15orf59

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000249700ENST00000558834TMOD2chr15

52075025

+C15orf59chr15

74032983

-
5CDS-intronENST00000539962ENST00000558834TMOD2chr15

52075025

+C15orf59chr15

74032983

-
In-frameENST00000249700ENST00000379822TMOD2chr15

52075025

+C15orf59chr15

74032983

-
In-frameENST00000249700ENST00000569673TMOD2chr15

52075025

+C15orf59chr15

74032983

-
In-frameENST00000539962ENST00000379822TMOD2chr15

52075025

+C15orf59chr15

74032983

-
In-frameENST00000539962ENST00000569673TMOD2chr15

52075025

+C15orf59chr15

74032983

-
intron-3CDSENST00000435126ENST00000379822TMOD2chr15

52075025

+C15orf59chr15

74032983

-
intron-3CDSENST00000435126ENST00000569673TMOD2chr15

52075025

+C15orf59chr15

74032983

-
intron-intronENST00000435126ENST00000558834TMOD2chr15

52075025

+C15orf59chr15

74032983

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000249700TMOD2chr1552075025+ENST00000569673C15orf59chr1574032983-17969532211678485
ENST00000249700TMOD2chr1552075025+ENST00000379822C15orf59chr1574032983-17859532211678485
ENST00000539962TMOD2chr1552075025+ENST00000569673C15orf59chr1574032983-18429993061724472
ENST00000539962TMOD2chr1552075025+ENST00000379822C15orf59chr1574032983-18319993061724472

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000249700ENST00000569673TMOD2chr1552075025+C15orf59chr1574032983-0.0043815690.99561846
ENST00000249700ENST00000379822TMOD2chr1552075025+C15orf59chr1574032983-0.0044911360.9955089
ENST00000539962ENST00000569673TMOD2chr1552075025+C15orf59chr1574032983-0.0049537840.99504626
ENST00000539962ENST00000379822TMOD2chr1552075025+C15orf59chr1574032983-0.0050962440.9949038

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Fusion Genomic Features for TMOD2-C15orf59


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMOD2-C15orf59


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:52075025/chr15:74032983)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneC15orf59chr15:52075025chr15:74032983ENST0000037982202207_21452294.0Compositional biasNote=Poly-Glu
TgeneC15orf59chr15:52075025chr15:74032983ENST0000056967313207_21452294.0Compositional biasNote=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneC15orf59chr15:52075025chr15:74032983ENST000003798220230_6352294.0Coiled coilOntology_term=ECO:0000255
TgeneC15orf59chr15:52075025chr15:74032983ENST000005696731330_6352294.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for TMOD2-C15orf59


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92326_92326_1_TMOD2-C15orf59_TMOD2_chr15_52075025_ENST00000249700_C15orf59_chr15_74032983_ENST00000379822_length(transcript)=1785nt_BP=953nt
GCGCGCCCCGGCGCCGCGCCCGGCCGGGAGCCGCCTGTTGATCGCCGCGCTCGCCCCGGCCACGGCGCCGCCCCTGTTCTCCCGGCCCCG
CTCCACCGGGGCTGACGGACTGACGGCCAGCACAGCCGGCTCCGGGATGAGCGCACGGACGGTATTCTGAAGTCTCAGGAAACTGGACCA
TTTAAATGTGCATGGCCCATGAGAAAGGCTTATAAGAAGCCATGGCACTCCCCTTTCAAAAAGAGCTGGAGAAATACAAGAACATTGATG
AAGATGAGCTTCTTGGCAAACTCTCAGAAGAGGAACTGAAACAGTTGGAAAATGTTCTAGATGACCTAGATCCTGAGAGTGCCATGCTGC
CAGCTGGATTTCGACAGAAAGACCAGACACAGAAGGCAGCCACCGGCCCCTTTGACCGCGAGCACCTCCTCATGTACCTGGAGAAGGAGG
CTTTGGAACAGAAAGACAGAGAGGACTTTGTGCCCTTCACTGGAGAAAAGAAAGGGAGAGTCTTTATCCCTAAAGAAAAGCCTATAGAAA
CTCGTAAAGAAGAAAAAGTGACCCTTGACCCAGAACTGGAAGAAGCTTTGGCCAGTGCCTCTGACACCGAACTCTATGATCTTGCAGCTG
TCCTTGGAGTACACAATTTGCTCAACAATCCAAAGTTCGATGAAGAAACAGCCAACAATAAAGGTGGCAAAGGACCTGTCAGAAATGTTG
TCAAAGGTGAAAAAGTAAAGCCAGTATTTGAGGAACCACCAAATCCCACAAATGTGGAAATAAGCCTGCAGCAGATGAAAGCCAATGATC
CTAGCTTGCAAGAAGTCAACCTCAACAACATTAAGAACATTCCAATTCCAACCCTGAGGGAATTTGCAAAGGCTCTGGAGACCAACACTC
ACGTGAAGAAGTTCAGCCTGGCCGCAACTCGCAGCAATGACCCTGTGGCCATTGTGGTGAGCCAGATCGATAAGCTAACCTCGGACTTCG
ACTTTGAACTGGAGCCGGACGACTGGACCACGGCCACTGTGAGCAGCACCTCTAGCAGTGACAAGGCGGGCATGGGTGGCCCCTTTGACC
TGGGCCACCTGGACTTCATGACAGCCGATATCCTCTCAGACAGCTGGGAGTTCTGCTCCTTCCTGGACGTCTCTACCCCCTCGGACTCCG
TGGATGGTCCCGAGTCGACTCGGCCAGGGGCTGGCCCTGACTACCGCCTCATGAATGGTGGCACGCCCATCCCCAATGGGCCACGAGTGG
AGACCCCAGACTCCTCCAGTGAGGAGGCCTTTGGTGCTGGCCCCACGGTGAAGAGCCAGCTGCCCCAGCGGACCCCAGGGACACGGGAGA
GGGTGCGGTTCAGTGACAAAGTGCTCTACCATGCTCTGTGCTGTGACGATGAGGAGGGGGACGGTGAGCAGGAGGTGGAGGAGGAAGAAG
TGGGCTTGCCCCCTGAGCCTGCCCATACAGAGGCCCATGCAGGCCCCCACAAGCCCTCCCCAGCCCCCTACAAGTCACGGCGCTCTCCAC
TGACCAGCCGCCACTCAGGCTCTACCTTGGCCCCTGAACAGACTCGAAGGGTCACGAGGAACAGCAGCACCCAGACAGTGTCAGACAAGA
GCACGCAGACGGTTCTGCCCTACACAGCCACTAGACAGAAAGCCAGGGGGAAAAACTAGGGGCCGGGGAGGGGGCCGGGGGCGGTGGGCA

>92326_92326_1_TMOD2-C15orf59_TMOD2_chr15_52075025_ENST00000249700_C15orf59_chr15_74032983_ENST00000379822_length(amino acids)=485AA_BP=244
MALPFQKELEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESAMLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFT
GEKKGRVFIPKEKPIETRKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETANNKGGKGPVRNVVKGEKVKPVFEEPP
NPTNVEISLQQMKANDPSLQEVNLNNIKNIPIPTLREFAKALETNTHVKKFSLAATRSNDPVAIVVSQIDKLTSDFDFELEPDDWTTATV
SSTSSSDKAGMGGPFDLGHLDFMTADILSDSWEFCSFLDVSTPSDSVDGPESTRPGAGPDYRLMNGGTPIPNGPRVETPDSSSEEAFGAG
PTVKSQLPQRTPGTRERVRFSDKVLYHALCCDDEEGDGEQEVEEEEVGLPPEPAHTEAHAGPHKPSPAPYKSRRSPLTSRHSGSTLAPEQ

--------------------------------------------------------------
>92326_92326_2_TMOD2-C15orf59_TMOD2_chr15_52075025_ENST00000249700_C15orf59_chr15_74032983_ENST00000569673_length(transcript)=1796nt_BP=953nt
GCGCGCCCCGGCGCCGCGCCCGGCCGGGAGCCGCCTGTTGATCGCCGCGCTCGCCCCGGCCACGGCGCCGCCCCTGTTCTCCCGGCCCCG
CTCCACCGGGGCTGACGGACTGACGGCCAGCACAGCCGGCTCCGGGATGAGCGCACGGACGGTATTCTGAAGTCTCAGGAAACTGGACCA
TTTAAATGTGCATGGCCCATGAGAAAGGCTTATAAGAAGCCATGGCACTCCCCTTTCAAAAAGAGCTGGAGAAATACAAGAACATTGATG
AAGATGAGCTTCTTGGCAAACTCTCAGAAGAGGAACTGAAACAGTTGGAAAATGTTCTAGATGACCTAGATCCTGAGAGTGCCATGCTGC
CAGCTGGATTTCGACAGAAAGACCAGACACAGAAGGCAGCCACCGGCCCCTTTGACCGCGAGCACCTCCTCATGTACCTGGAGAAGGAGG
CTTTGGAACAGAAAGACAGAGAGGACTTTGTGCCCTTCACTGGAGAAAAGAAAGGGAGAGTCTTTATCCCTAAAGAAAAGCCTATAGAAA
CTCGTAAAGAAGAAAAAGTGACCCTTGACCCAGAACTGGAAGAAGCTTTGGCCAGTGCCTCTGACACCGAACTCTATGATCTTGCAGCTG
TCCTTGGAGTACACAATTTGCTCAACAATCCAAAGTTCGATGAAGAAACAGCCAACAATAAAGGTGGCAAAGGACCTGTCAGAAATGTTG
TCAAAGGTGAAAAAGTAAAGCCAGTATTTGAGGAACCACCAAATCCCACAAATGTGGAAATAAGCCTGCAGCAGATGAAAGCCAATGATC
CTAGCTTGCAAGAAGTCAACCTCAACAACATTAAGAACATTCCAATTCCAACCCTGAGGGAATTTGCAAAGGCTCTGGAGACCAACACTC
ACGTGAAGAAGTTCAGCCTGGCCGCAACTCGCAGCAATGACCCTGTGGCCATTGTGGTGAGCCAGATCGATAAGCTAACCTCGGACTTCG
ACTTTGAACTGGAGCCGGACGACTGGACCACGGCCACTGTGAGCAGCACCTCTAGCAGTGACAAGGCGGGCATGGGTGGCCCCTTTGACC
TGGGCCACCTGGACTTCATGACAGCCGATATCCTCTCAGACAGCTGGGAGTTCTGCTCCTTCCTGGACGTCTCTACCCCCTCGGACTCCG
TGGATGGTCCCGAGTCGACTCGGCCAGGGGCTGGCCCTGACTACCGCCTCATGAATGGTGGCACGCCCATCCCCAATGGGCCACGAGTGG
AGACCCCAGACTCCTCCAGTGAGGAGGCCTTTGGTGCTGGCCCCACGGTGAAGAGCCAGCTGCCCCAGCGGACCCCAGGGACACGGGAGA
GGGTGCGGTTCAGTGACAAAGTGCTCTACCATGCTCTGTGCTGTGACGATGAGGAGGGGGACGGTGAGCAGGAGGTGGAGGAGGAAGAAG
TGGGCTTGCCCCCTGAGCCTGCCCATACAGAGGCCCATGCAGGCCCCCACAAGCCCTCCCCAGCCCCCTACAAGTCACGGCGCTCTCCAC
TGACCAGCCGCCACTCAGGCTCTACCTTGGCCCCTGAACAGACTCGAAGGGTCACGAGGAACAGCAGCACCCAGACAGTGTCAGACAAGA
GCACGCAGACGGTTCTGCCCTACACAGCCACTAGACAGAAAGCCAGGGGGAAAAACTAGGGGCCGGGGAGGGGGCCGGGGGCGGTGGGCA

>92326_92326_2_TMOD2-C15orf59_TMOD2_chr15_52075025_ENST00000249700_C15orf59_chr15_74032983_ENST00000569673_length(amino acids)=485AA_BP=244
MALPFQKELEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESAMLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFT
GEKKGRVFIPKEKPIETRKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETANNKGGKGPVRNVVKGEKVKPVFEEPP
NPTNVEISLQQMKANDPSLQEVNLNNIKNIPIPTLREFAKALETNTHVKKFSLAATRSNDPVAIVVSQIDKLTSDFDFELEPDDWTTATV
SSTSSSDKAGMGGPFDLGHLDFMTADILSDSWEFCSFLDVSTPSDSVDGPESTRPGAGPDYRLMNGGTPIPNGPRVETPDSSSEEAFGAG
PTVKSQLPQRTPGTRERVRFSDKVLYHALCCDDEEGDGEQEVEEEEVGLPPEPAHTEAHAGPHKPSPAPYKSRRSPLTSRHSGSTLAPEQ

--------------------------------------------------------------
>92326_92326_3_TMOD2-C15orf59_TMOD2_chr15_52075025_ENST00000539962_C15orf59_chr15_74032983_ENST00000379822_length(transcript)=1831nt_BP=999nt
GTTGATCGCCGCGCTCGCCCCGGCCACGGCGCCGCCCCTGTTCTCCCGGCCCCGCTCCACCGGGGCTGACGGACTGACGGCCAGCACAGC
CGGCTCCGGGATGAGCGCACGGACGGTATTCTGAAGTCTCAGGAAACTGGACCATTTAAATGTGCATGGCCCATGAGAAAGGCTTATAAG
AAGCCATGGCACTCCCCTTTCAAAAAGAGCTGGAGAAATACAAGAACATTGATGAAGATGAGCTTCTTGGCAAACTCTCAGAAGAGGAAC
TGAAACAGTTGGAAAATGTTCTAGATGACCTAGATCCTGAGGCTGGAGTGCCGTGGCAAGATCTCGGCTCACTGCAACCTCTGCCTCCCA
GATTCAAGCGATTCTCCTACCTCAGCCTCCCAGAGTGCCATGCTGCCAGCTGGATTTCGACAGAAAGACCAGACACAGAAGGCAGCCACC
GGCCCCTTTGACCGCGAGCACCTCCTCATGTACCTGGAGAAGGAGGCTTTGGAACAGAAAGACAGAGAGGACTTTGTGCCCTTCACTGGA
GAAAAGAAAGGGAGAGTCTTTATCCCTAAAGAAAAGCCTATAGAAACTCGTAAAGAAGAAAAAGTGACCCTTGACCCAGAACTGGAAGAA
GCTTTGGCCAGTGCCTCTGACACCGAACTCTATGATCTTGCAGCTGTCCTTGGAGTACACAATTTGCTCAACAATCCAAAGTTCGATGAA
GAAACAGCCAACAATAAAGGTGGCAAAGGACCTGTCAGAAATGTTGTCAAAGGTGAAAAAGTAAAGCCAGTATTTGAGGAACCACCAAAT
CCCACAAATGTGGAAATAAGCCTGCAGCAGATGAAAGCCAATGATCCTAGCTTGCAAGAAGTCAACCTCAACAACATTAAGAACATTCCA
ATTCCAACCCTGAGGGAATTTGCAAAGGCTCTGGAGACCAACACTCACGTGAAGAAGTTCAGCCTGGCCGCAACTCGCAGCAATGACCCT
GTGGCCATTGTGGTGAGCCAGATCGATAAGCTAACCTCGGACTTCGACTTTGAACTGGAGCCGGACGACTGGACCACGGCCACTGTGAGC
AGCACCTCTAGCAGTGACAAGGCGGGCATGGGTGGCCCCTTTGACCTGGGCCACCTGGACTTCATGACAGCCGATATCCTCTCAGACAGC
TGGGAGTTCTGCTCCTTCCTGGACGTCTCTACCCCCTCGGACTCCGTGGATGGTCCCGAGTCGACTCGGCCAGGGGCTGGCCCTGACTAC
CGCCTCATGAATGGTGGCACGCCCATCCCCAATGGGCCACGAGTGGAGACCCCAGACTCCTCCAGTGAGGAGGCCTTTGGTGCTGGCCCC
ACGGTGAAGAGCCAGCTGCCCCAGCGGACCCCAGGGACACGGGAGAGGGTGCGGTTCAGTGACAAAGTGCTCTACCATGCTCTGTGCTGT
GACGATGAGGAGGGGGACGGTGAGCAGGAGGTGGAGGAGGAAGAAGTGGGCTTGCCCCCTGAGCCTGCCCATACAGAGGCCCATGCAGGC
CCCCACAAGCCCTCCCCAGCCCCCTACAAGTCACGGCGCTCTCCACTGACCAGCCGCCACTCAGGCTCTACCTTGGCCCCTGAACAGACT
CGAAGGGTCACGAGGAACAGCAGCACCCAGACAGTGTCAGACAAGAGCACGCAGACGGTTCTGCCCTACACAGCCACTAGACAGAAAGCC
AGGGGGAAAAACTAGGGGCCGGGGAGGGGGCCGGGGGCGGTGGGCACATAGAGCTATAAATAAATATATATATATATATATATATATATA

>92326_92326_3_TMOD2-C15orf59_TMOD2_chr15_52075025_ENST00000539962_C15orf59_chr15_74032983_ENST00000379822_length(amino acids)=472AA_BP=8
MRLECRGKISAHCNLCLPDSSDSPTSASQSAMLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEK
PIETRKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETANNKGGKGPVRNVVKGEKVKPVFEEPPNPTNVEISLQQMK
ANDPSLQEVNLNNIKNIPIPTLREFAKALETNTHVKKFSLAATRSNDPVAIVVSQIDKLTSDFDFELEPDDWTTATVSSTSSSDKAGMGG
PFDLGHLDFMTADILSDSWEFCSFLDVSTPSDSVDGPESTRPGAGPDYRLMNGGTPIPNGPRVETPDSSSEEAFGAGPTVKSQLPQRTPG
TRERVRFSDKVLYHALCCDDEEGDGEQEVEEEEVGLPPEPAHTEAHAGPHKPSPAPYKSRRSPLTSRHSGSTLAPEQTRRVTRNSSTQTV

--------------------------------------------------------------
>92326_92326_4_TMOD2-C15orf59_TMOD2_chr15_52075025_ENST00000539962_C15orf59_chr15_74032983_ENST00000569673_length(transcript)=1842nt_BP=999nt
GTTGATCGCCGCGCTCGCCCCGGCCACGGCGCCGCCCCTGTTCTCCCGGCCCCGCTCCACCGGGGCTGACGGACTGACGGCCAGCACAGC
CGGCTCCGGGATGAGCGCACGGACGGTATTCTGAAGTCTCAGGAAACTGGACCATTTAAATGTGCATGGCCCATGAGAAAGGCTTATAAG
AAGCCATGGCACTCCCCTTTCAAAAAGAGCTGGAGAAATACAAGAACATTGATGAAGATGAGCTTCTTGGCAAACTCTCAGAAGAGGAAC
TGAAACAGTTGGAAAATGTTCTAGATGACCTAGATCCTGAGGCTGGAGTGCCGTGGCAAGATCTCGGCTCACTGCAACCTCTGCCTCCCA
GATTCAAGCGATTCTCCTACCTCAGCCTCCCAGAGTGCCATGCTGCCAGCTGGATTTCGACAGAAAGACCAGACACAGAAGGCAGCCACC
GGCCCCTTTGACCGCGAGCACCTCCTCATGTACCTGGAGAAGGAGGCTTTGGAACAGAAAGACAGAGAGGACTTTGTGCCCTTCACTGGA
GAAAAGAAAGGGAGAGTCTTTATCCCTAAAGAAAAGCCTATAGAAACTCGTAAAGAAGAAAAAGTGACCCTTGACCCAGAACTGGAAGAA
GCTTTGGCCAGTGCCTCTGACACCGAACTCTATGATCTTGCAGCTGTCCTTGGAGTACACAATTTGCTCAACAATCCAAAGTTCGATGAA
GAAACAGCCAACAATAAAGGTGGCAAAGGACCTGTCAGAAATGTTGTCAAAGGTGAAAAAGTAAAGCCAGTATTTGAGGAACCACCAAAT
CCCACAAATGTGGAAATAAGCCTGCAGCAGATGAAAGCCAATGATCCTAGCTTGCAAGAAGTCAACCTCAACAACATTAAGAACATTCCA
ATTCCAACCCTGAGGGAATTTGCAAAGGCTCTGGAGACCAACACTCACGTGAAGAAGTTCAGCCTGGCCGCAACTCGCAGCAATGACCCT
GTGGCCATTGTGGTGAGCCAGATCGATAAGCTAACCTCGGACTTCGACTTTGAACTGGAGCCGGACGACTGGACCACGGCCACTGTGAGC
AGCACCTCTAGCAGTGACAAGGCGGGCATGGGTGGCCCCTTTGACCTGGGCCACCTGGACTTCATGACAGCCGATATCCTCTCAGACAGC
TGGGAGTTCTGCTCCTTCCTGGACGTCTCTACCCCCTCGGACTCCGTGGATGGTCCCGAGTCGACTCGGCCAGGGGCTGGCCCTGACTAC
CGCCTCATGAATGGTGGCACGCCCATCCCCAATGGGCCACGAGTGGAGACCCCAGACTCCTCCAGTGAGGAGGCCTTTGGTGCTGGCCCC
ACGGTGAAGAGCCAGCTGCCCCAGCGGACCCCAGGGACACGGGAGAGGGTGCGGTTCAGTGACAAAGTGCTCTACCATGCTCTGTGCTGT
GACGATGAGGAGGGGGACGGTGAGCAGGAGGTGGAGGAGGAAGAAGTGGGCTTGCCCCCTGAGCCTGCCCATACAGAGGCCCATGCAGGC
CCCCACAAGCCCTCCCCAGCCCCCTACAAGTCACGGCGCTCTCCACTGACCAGCCGCCACTCAGGCTCTACCTTGGCCCCTGAACAGACT
CGAAGGGTCACGAGGAACAGCAGCACCCAGACAGTGTCAGACAAGAGCACGCAGACGGTTCTGCCCTACACAGCCACTAGACAGAAAGCC
AGGGGGAAAAACTAGGGGCCGGGGAGGGGGCCGGGGGCGGTGGGCACATAGAGCTATAAATAAATATATATATATATATATATATATATA

>92326_92326_4_TMOD2-C15orf59_TMOD2_chr15_52075025_ENST00000539962_C15orf59_chr15_74032983_ENST00000569673_length(amino acids)=472AA_BP=8
MRLECRGKISAHCNLCLPDSSDSPTSASQSAMLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEK
PIETRKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETANNKGGKGPVRNVVKGEKVKPVFEEPPNPTNVEISLQQMK
ANDPSLQEVNLNNIKNIPIPTLREFAKALETNTHVKKFSLAATRSNDPVAIVVSQIDKLTSDFDFELEPDDWTTATVSSTSSSDKAGMGG
PFDLGHLDFMTADILSDSWEFCSFLDVSTPSDSVDGPESTRPGAGPDYRLMNGGTPIPNGPRVETPDSSSEEAFGAGPTVKSQLPQRTPG
TRERVRFSDKVLYHALCCDDEEGDGEQEVEEEEVGLPPEPAHTEAHAGPHKPSPAPYKSRRSPLTSRHSGSTLAPEQTRRVTRNSSTQTV

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Fusion Gene PPI Analysis for TMOD2-C15orf59


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMOD2-C15orf59


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMOD2-C15orf59


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource