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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMPRSS2-GRHL2 (FusionGDB2 ID:92382)

Fusion Gene Summary for TMPRSS2-GRHL2

check button Fusion gene summary
Fusion gene informationFusion gene name: TMPRSS2-GRHL2
Fusion gene ID: 92382
HgeneTgene
Gene symbol

TMPRSS2

GRHL2

Gene ID

7113

79977

Gene nametransmembrane serine protease 2grainyhead like transcription factor 2
SynonymsPP9284|PRSS10BOM|DFNA28|ECTDS|PPCD4|TFCP2L3
Cytomap

21q22.3

8q22.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2grainyhead-like protein 2 homologbrother of mammalian grainyheadgrainyhead-like 2transcription factor CP2-like 3
Modification date2020031320200313
UniProtAcc.

Q6ISB3

Ensembl transtripts involved in fusion geneENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
ENST00000517674, ENST00000251808, 
ENST00000395927, 
Fusion gene scores* DoF score40 X 73 X 10=292008 X 8 X 5=320
# samples 1308
** MAII scorelog2(130/29200*10)=-4.48938484073892
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/320*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMPRSS2 [Title/Abstract] AND GRHL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMPRSS2(42861433)-GRHL2(102564942), # samples:3
TMPRSS2(42860320)-GRHL2(102564942), # samples:3
Anticipated loss of major functional domain due to fusion event.TMPRSS2-GRHL2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-GRHL2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TMPRSS2-GRHL2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TMPRSS2-GRHL2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

HgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843

TgeneGRHL2

GO:0008544

epidermis development

23254293

TgeneGRHL2

GO:0044030

regulation of DNA methylation

23254293

TgeneGRHL2

GO:0045617

negative regulation of keratinocyte differentiation

23254293

TgeneGRHL2

GO:0045944

positive regulation of transcription by RNA polymerase II

23814079


check buttonFusion gene breakpoints across TMPRSS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRHL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-7314-01ATMPRSS2chr21

42860320

-GRHL2chr8

102564942

+
ChimerDB4PRADTCGA-EJ-7314-01ATMPRSS2chr21

42861433

-GRHL2chr8

102564942

+
ChimerDB4PRADTCGA-EJ-7314TMPRSS2chr21

42860320

-GRHL2chr8

102564942

+
ChimerDB4PRADTCGA-EJ-7314TMPRSS2chr21

42860321

-GRHL2chr8

102564943

+
ChimerDB4PRADTCGA-EJ-7314TMPRSS2chr21

42861433

-GRHL2chr8

102564942

+
ChimerDB4PRADTCGA-EJ-7314TMPRSS2chr21

42861434

-GRHL2chr8

102564943

+


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Fusion Gene ORF analysis for TMPRSS2-GRHL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000332149ENST00000517674TMPRSS2chr21

42860320

-GRHL2chr8

102564942

+
5CDS-intronENST00000332149ENST00000517674TMPRSS2chr21

42860321

-GRHL2chr8

102564943

+
5CDS-intronENST00000332149ENST00000517674TMPRSS2chr21

42861433

-GRHL2chr8

102564942

+
5CDS-intronENST00000332149ENST00000517674TMPRSS2chr21

42861434

-GRHL2chr8

102564943

+
5CDS-intronENST00000398585ENST00000517674TMPRSS2chr21

42860320

-GRHL2chr8

102564942

+
5CDS-intronENST00000398585ENST00000517674TMPRSS2chr21

42860321

-GRHL2chr8

102564943

+
5CDS-intronENST00000398585ENST00000517674TMPRSS2chr21

42861433

-GRHL2chr8

102564942

+
5CDS-intronENST00000398585ENST00000517674TMPRSS2chr21

42861434

-GRHL2chr8

102564943

+
5CDS-intronENST00000458356ENST00000517674TMPRSS2chr21

42860320

-GRHL2chr8

102564942

+
5CDS-intronENST00000458356ENST00000517674TMPRSS2chr21

42860321

-GRHL2chr8

102564943

+
5CDS-intronENST00000458356ENST00000517674TMPRSS2chr21

42861433

-GRHL2chr8

102564942

+
5CDS-intronENST00000458356ENST00000517674TMPRSS2chr21

42861434

-GRHL2chr8

102564943

+
Frame-shiftENST00000332149ENST00000251808TMPRSS2chr21

42860320

-GRHL2chr8

102564942

+
Frame-shiftENST00000332149ENST00000251808TMPRSS2chr21

42860321

-GRHL2chr8

102564943

+
Frame-shiftENST00000332149ENST00000251808TMPRSS2chr21

42861433

-GRHL2chr8

102564942

+
Frame-shiftENST00000332149ENST00000251808TMPRSS2chr21

42861434

-GRHL2chr8

102564943

+
Frame-shiftENST00000332149ENST00000395927TMPRSS2chr21

42860320

-GRHL2chr8

102564942

+
Frame-shiftENST00000332149ENST00000395927TMPRSS2chr21

42860321

-GRHL2chr8

102564943

+
Frame-shiftENST00000332149ENST00000395927TMPRSS2chr21

42861433

-GRHL2chr8

102564942

+
Frame-shiftENST00000332149ENST00000395927TMPRSS2chr21

42861434

-GRHL2chr8

102564943

+
Frame-shiftENST00000398585ENST00000251808TMPRSS2chr21

42860320

-GRHL2chr8

102564942

+
Frame-shiftENST00000398585ENST00000251808TMPRSS2chr21

42860321

-GRHL2chr8

102564943

+
Frame-shiftENST00000398585ENST00000251808TMPRSS2chr21

42861433

-GRHL2chr8

102564942

+
Frame-shiftENST00000398585ENST00000251808TMPRSS2chr21

42861434

-GRHL2chr8

102564943

+
Frame-shiftENST00000398585ENST00000395927TMPRSS2chr21

42860320

-GRHL2chr8

102564942

+
Frame-shiftENST00000398585ENST00000395927TMPRSS2chr21

42860321

-GRHL2chr8

102564943

+
Frame-shiftENST00000398585ENST00000395927TMPRSS2chr21

42861433

-GRHL2chr8

102564942

+
Frame-shiftENST00000398585ENST00000395927TMPRSS2chr21

42861434

-GRHL2chr8

102564943

+
In-frameENST00000458356ENST00000251808TMPRSS2chr21

42860320

-GRHL2chr8

102564942

+
In-frameENST00000458356ENST00000251808TMPRSS2chr21

42860321

-GRHL2chr8

102564943

+
In-frameENST00000458356ENST00000251808TMPRSS2chr21

42861433

-GRHL2chr8

102564942

+
In-frameENST00000458356ENST00000251808TMPRSS2chr21

42861434

-GRHL2chr8

102564943

+
In-frameENST00000458356ENST00000395927TMPRSS2chr21

42860320

-GRHL2chr8

102564942

+
In-frameENST00000458356ENST00000395927TMPRSS2chr21

42860321

-GRHL2chr8

102564943

+
In-frameENST00000458356ENST00000395927TMPRSS2chr21

42861433

-GRHL2chr8

102564942

+
In-frameENST00000458356ENST00000395927TMPRSS2chr21

42861434

-GRHL2chr8

102564943

+
intron-3CDSENST00000497881ENST00000251808TMPRSS2chr21

42860320

-GRHL2chr8

102564942

+
intron-3CDSENST00000497881ENST00000251808TMPRSS2chr21

42860321

-GRHL2chr8

102564943

+
intron-3CDSENST00000497881ENST00000251808TMPRSS2chr21

42861433

-GRHL2chr8

102564942

+
intron-3CDSENST00000497881ENST00000251808TMPRSS2chr21

42861434

-GRHL2chr8

102564943

+
intron-3CDSENST00000497881ENST00000395927TMPRSS2chr21

42860320

-GRHL2chr8

102564942

+
intron-3CDSENST00000497881ENST00000395927TMPRSS2chr21

42860321

-GRHL2chr8

102564943

+
intron-3CDSENST00000497881ENST00000395927TMPRSS2chr21

42861433

-GRHL2chr8

102564942

+
intron-3CDSENST00000497881ENST00000395927TMPRSS2chr21

42861434

-GRHL2chr8

102564943

+
intron-intronENST00000497881ENST00000517674TMPRSS2chr21

42860320

-GRHL2chr8

102564942

+
intron-intronENST00000497881ENST00000517674TMPRSS2chr21

42860321

-GRHL2chr8

102564943

+
intron-intronENST00000497881ENST00000517674TMPRSS2chr21

42861433

-GRHL2chr8

102564942

+
intron-intronENST00000497881ENST00000517674TMPRSS2chr21

42861434

-GRHL2chr8

102564943

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000458356TMPRSS2chr2142861433-ENST00000251808GRHL2chr8102564942+50994143812075564
ENST00000458356TMPRSS2chr2142861433-ENST00000395927GRHL2chr8102564942+22664143812075564
ENST00000458356TMPRSS2chr2142860320-ENST00000251808GRHL2chr8102564942+52195344892195568
ENST00000458356TMPRSS2chr2142860320-ENST00000395927GRHL2chr8102564942+23865344892195568
ENST00000458356TMPRSS2chr2142861434-ENST00000251808GRHL2chr8102564943+50994143812075564
ENST00000458356TMPRSS2chr2142861434-ENST00000395927GRHL2chr8102564943+22664143812075564
ENST00000458356TMPRSS2chr2142860321-ENST00000251808GRHL2chr8102564943+52195344892195568
ENST00000458356TMPRSS2chr2142860321-ENST00000395927GRHL2chr8102564943+23865344892195568

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000458356ENST00000251808TMPRSS2chr2142861433-GRHL2chr8102564942+0.0013152860.9986847
ENST00000458356ENST00000395927TMPRSS2chr2142861433-GRHL2chr8102564942+0.0045215030.9954786
ENST00000458356ENST00000251808TMPRSS2chr2142860320-GRHL2chr8102564942+0.0020737260.99792624
ENST00000458356ENST00000395927TMPRSS2chr2142860320-GRHL2chr8102564942+0.0066037860.9933962
ENST00000458356ENST00000251808TMPRSS2chr2142861434-GRHL2chr8102564943+0.0013152860.9986847
ENST00000458356ENST00000395927TMPRSS2chr2142861434-GRHL2chr8102564943+0.0045215030.9954786
ENST00000458356ENST00000251808TMPRSS2chr2142860321-GRHL2chr8102564943+0.0020737260.99792624
ENST00000458356ENST00000395927TMPRSS2chr2142860321-GRHL2chr8102564943+0.0066037860.9933962

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Fusion Genomic Features for TMPRSS2-GRHL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMPRSS2chr2142860320-GRHL2chr8102564942+0.211372020.788628
TMPRSS2chr2142860320-GRHL2chr8102564942+0.211372020.788628
TMPRSS2chr2142861433-GRHL2chr8102564942+0.096414150.90358585
TMPRSS2chr2142861433-GRHL2chr8102564942+0.096414150.90358585
TMPRSS2chr2142860320-GRHL2chr8102564942+0.211372020.788628
TMPRSS2chr2142860320-GRHL2chr8102564942+0.211372020.788628
TMPRSS2chr2142861433-GRHL2chr8102564942+0.096414150.90358585
TMPRSS2chr2142861433-GRHL2chr8102564942+0.096414150.90358585

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TMPRSS2-GRHL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:42861433/chr8:102564942)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GRHL2

Q6ISB3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:29309642, PubMed:25152456). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293). {ECO:0000250|UniProtKB:Q8K5C0, ECO:0000269|PubMed:19015635, ECO:0000269|PubMed:20938050, ECO:0000269|PubMed:20978075, ECO:0000269|PubMed:23254293, ECO:0000269|PubMed:25152456, ECO:0000269|PubMed:29309642, ECO:0000305|PubMed:12175488}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000332149-514112_149148493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000398585-514112_149185530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000458356-514112_149148493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000332149-514112_149148493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000398585-514112_149185530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000458356-514112_149148493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000332149-5141_84148493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000398585-5141_84185530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000458356-5141_84148493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000332149-5141_84148493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000398585-5141_84185530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000458356-5141_84148493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000332149-4141_84108493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000398585-4141_84145530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000458356-4141_84108493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000332149-4141_84108493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000398585-4141_84145530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000458356-4141_84108493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000332149-51485_105148493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000398585-51485_105185530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000458356-51485_105148493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000332149-51485_105148493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000398585-51485_105185530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000458356-51485_105148493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000332149-41485_105108493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000398585-41485_105145530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000458356-41485_105108493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000332149-41485_105108493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000398585-41485_105145530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000458356-41485_105108493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000332149-514150_242148493.0DomainSRCR
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000332149-514256_489148493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000398585-514150_242185530.0DomainSRCR
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000398585-514256_489185530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000458356-514150_242148493.0DomainSRCR
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000458356-514256_489148493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000332149-514150_242148493.0DomainSRCR
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000332149-514256_489148493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000398585-514150_242185530.0DomainSRCR
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000398585-514256_489185530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000458356-514150_242148493.0DomainSRCR
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000458356-514256_489148493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000332149-414112_149108493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000332149-414150_242108493.0DomainSRCR
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000332149-414256_489108493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000398585-414112_149145530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000398585-414150_242145530.0DomainSRCR
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000398585-414256_489145530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000458356-414112_149108493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000458356-414150_242108493.0DomainSRCR
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000458356-414256_489108493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000332149-414112_149108493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000332149-414150_242108493.0DomainSRCR
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000332149-414256_489108493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000398585-414112_149145530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000398585-414150_242145530.0DomainSRCR
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000398585-414256_489145530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000458356-414112_149108493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000458356-414150_242108493.0DomainSRCR
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000458356-414256_489108493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000332149-514106_492148493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000398585-514106_492185530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42860320chr8:102564942ENST00000458356-514106_492148493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000332149-514106_492148493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000398585-514106_492185530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42860321chr8:102564943ENST00000458356-514106_492148493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000332149-414106_492108493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000398585-414106_492145530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42861433chr8:102564942ENST00000458356-414106_492108493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000332149-414106_492108493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000398585-414106_492145530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42861434chr8:102564943ENST00000458356-414106_492108493.0Topological domainExtracellular
TgeneGRHL2chr21:42860320chr8:102564942ENST000002518081161_9372626.0RegionTranscription activation
TgeneGRHL2chr21:42860320chr8:102564942ENST000003959271161_9356610.0RegionTranscription activation
TgeneGRHL2chr21:42860321chr8:102564943ENST000002518081161_9372626.0RegionTranscription activation
TgeneGRHL2chr21:42860321chr8:102564943ENST000003959271161_9356610.0RegionTranscription activation
TgeneGRHL2chr21:42861433chr8:102564942ENST000002518081161_9372626.0RegionTranscription activation
TgeneGRHL2chr21:42861433chr8:102564942ENST000003959271161_9356610.0RegionTranscription activation
TgeneGRHL2chr21:42861434chr8:102564943ENST000002518081161_9372626.0RegionTranscription activation
TgeneGRHL2chr21:42861434chr8:102564943ENST000003959271161_9356610.0RegionTranscription activation


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Fusion Gene Sequence for TMPRSS2-GRHL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92382_92382_1_TMPRSS2-GRHL2_TMPRSS2_chr21_42860320_ENST00000458356_GRHL2_chr8_102564942_ENST00000251808_length(transcript)=5219nt_BP=534nt
GTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGA
TGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCA
CTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTT
CCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCC
TGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCG
ACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGGTTCCT
CGAGACAAGAGGCTGCTGTCTGTAAGCAAAGCAAGTGACAGCCAAGAAGACCAGGAGAAAAGAAACTGCCTTGGCACCAGTGAAGCCCAG
AGTAATTTGAGTGGAGGAGAAAACCGAGTGCAAGTCCTAAAGACTGTTCCAGTGAACCTTTCCCTAAATCAAGATCACCTGGAGAATTCC
AAGCGGGAACAGTACAGCATCAGCTTCCCCGAGAGCTCTGCCATCATCCCGGTGTCGGGAATCACGGTGGTGAAAGCTGAAGATTTCACA
CCAGTTTTCATGGCCCCACCTGTGCACTATCCCCGGGGAGATGGGGAAGAGCAACGAGTGGTTATCTTTGAACAGACTCAGTATGACGTG
CCCTCGCTGGCCACCCACAGCGCCTATCTCAAAGACGACCAGCGCAGCACTCCGGACAGCACATACAGCGAGAGCTTCAAGGACGCAGCC
ACAGAGAAATTTCGGAGTGCTTCAGTTGGGGCTGAGGAGTACATGTATGATCAGACATCAAGTGGCACATTTCAGTACACCCTGGAAGCC
ACCAAATCTCTCCGTCAGAAGCAGGGGGAGGGCCCCATGACCTACCTCAACAAAGGACAGTTCTATGCCATAACACTCAGCGAGACCGGA
GACAACAAATGCTTCCGACACCCCATCAGCAAAGTCAGGAGTGTGGTGATGGTGGTCTTCAGTGAAGACAAAAACAGAGATGAACAGCTC
AAATACTGGAAATACTGGCACTCTCGGCAGCATACGGCGAAGCAGAGGGTCCTTGACATTGCCGATTACAAGGAGAGCTTTAATACGATT
GGAAACATTGAAGAGATTGCATATAATGCTGTTTCCTTTACCTGGGACGTGAATGAAGAGGCGAAGATTTTCATCACCGTGAATTGCTTG
AGCACAGATTTCTCCTCCCAAAAAGGGGTGAAAGGACTTCCTTTGATGATTCAGATTGACACATACAGTTATAACAATCGTAGCAATAAA
CCCATTCATAGAGCTTATTGCCAGATCAAGGTCTTCTGTGACAAAGGAGCAGAAAGAAAAATCCGAGATGAAGAGCGGAAGCAGAACAGG
AAGAAAGGGAAAGGCCAGGCCTCCCAAACTCAATGCAACAGCTCCTCTGATGGGAAGTTGGCTGCCATACCTTTACAGAAGAAGAGTGAC
ATCACCTACTTCAAAACCATGCCTGATCTCCACTCACAGCCAGTTCTCTTCATACCTGATGTTCACTTTGCAAACCTGCAGAGGACCGGA
CAGGTGTATTACAACACGGATGATGAACGAGAAGGTGGCAGTGTCCTTGTTAAACGGATGTTCCGGCCCATGGAAGAGGAGTTTGGTCCA
GTGCCTTCAAAGCAGATGAAAGAAGAAGGGACAAAGCGAGTGCTCTTGTACGTGAGGAAGGAGACTGACGATGTGTTCGATGCATTGATG
TTGAAGTCTCCCACAGTGAAGGGCCTGATGGAAGCGATATCTGAGAAATATGGGCTGCCCGTGGAGAAGATAGCAAAGCTTTACAAGAAA
AGCAAAAAAGGCATCTTGGTGAACATGGATGACAACATCATCGAGCACTACTCGAACGAGGACACCTTCATCCTCAACATGGAGAGCATG
GTGGAGGGCTTCAAGGTCACGCTCATGGAAATCTAGCCCTGGGTTTGGCATCCGCTTTGGCTGGAGCTCTCAGTGCGTTCCTCCCTGAGA
GAGACAGAAGCCCCAGCCCCAGAACCTGGAGACCCATCTCCCCCATCTCACAACTGCTGTTACAAGACCGTGCTGGGGAGTGGGGCAAGG
GACAGGCCCCACTGTCGGTGTGCTTGGCCCATCCACTGGCACCTACCACGGAGCTGAAGCCTGAGCCCCTCAGGAAGGTGCCTTAGGCCT
GTTGGATTCCTATTTATTGCCCACCTTTTCCTGGAGCCCAGGTCCAGGCCCGCCAGGACTCTGCAGGTCACTGCTAGCTCCAGATGAGAC
CGTCCAGCGTTCCCCCTTCAAGAGAAACACTCATCCCGAACAGCCTAAAAAATTCCCATCCCTTCTCTCTCACCCCTCCATATCTATCTC
CCGAGTGGCTGGACAAAATGAGCTACGTCTGGGTGCAGTAGTTATAGGTGGGGCAAGAGGTGGATGCCCACTTTCTGGTCAGACACCTTT
AGGTTGCTCTGGGGAAGGCTGTCTTGCTAAATACCTCCAGGGTTCCCAGCAAGTGGCCACCAGGCCTTGTACAGGAAGACATTCAGTCAC
CGTGTAATTAGTAACACAGAAAGTCTGCCTGTCTGCATTGTACATAGTGTTTATAATATTGTAATAATATATTTTACCTGTGGTATGTGG
GCATGTTTACTGCCACTGGCCTAGAGGAGACACAGACCTGGAGACCGTTTTAATGGGGGTTTTTGCCTCTGTGCCTGTTCAAGAGACTTG
CAGGGCTAGGTAGAGGGCCTTTGGGATGTTAAGGTGACTGCAGCTGATGCCAAGATGGACTCTGCAATGGGCATACCTGGGGGCTCGTTC
CCTGTCCCCAGAGGAAGCCCCCTCTCCTTCTCCATGGGCATGACTCTCCTTCGAGGCCACCACGTTTATCTCACAATGATGTGTTTTGCT
TGACTTTCCCTTTGCGCTGTCTCGTGGGAAAGGTCATTCTGTCTGAGACCCCAGCTCCTTCTCCAGCTTTGGCTGCGGGCATGGCCTGAG
CTTTCTGGAGAGCCTCTGCAGGGGGTTTGCCATCAGGGCCCTGTGGCTGGGTCTGCTGCAGAGCTCCTTGGCTATCAGGAGAATCCTGGA
CACTGTACTGTGCCTCCCAGTTTACAAACACGCCCTTCATCTCAAGTGGCCCTTTAAAAGGCCTGCTGCCATGTGAGAGCTGTGAACAGC
TCAGCTCTGAGTCGGCAGGCTGGGGCTTCCTCCTGGGCCACCAGATGGAAAGGGGGTATTGTTTGCCTCACTCCTGGATGCTGCGTTTTA
AGGAAGTGAGTGAGAAAGAATGTGCCAAGATACCTGGCTCCTGTGAAACCAGCCTCAGGAGGGAAACTGGGAGAGAGAAGCTGTGGTCTC
CTGCTACATGCCCTGGGAGCTGGAAGAGAAAAACACTCCCCTAAACAATCGCAAAATGATGAACCATCATGGGCCACTGTTCTCTTTGAG
GGGACAGGTTTAGGGGTTTGCGTTCGCCCTTGTGGGCTGAAGCACTAGCTTTTTGGTAGCTAGACACATCCTGCACCCAAAGGTTCTCTA
CAAAGGCCCAGATTTGTTTGTAAAGCACTTTGACTCTTACCTGGAGGCCCGCTCTCTAAGGGCTTCCTGCGCTCCCACCTCATCTGTCCC
TGAGATGCAGAGCAGGATGGAGGGTCTGCTTCTAGCTCAGCTGTTTCTCCTTGAGGTTGCGGAGGAATTGAATTGAATGGGACAGAGGGC
AGGTGCTGTGGCCAAGAAGATCTCCGAGCAGCAGTGACGGGGCACCTTGCTGTGTGTCCTCTGGGCATGTTAACCCTTCTGTGGGGCCAA
AGGTTTGCATCGTGGATCCAGCTGTGCTCCAGTCTGTCCCCTCCTCCTCCACTCTGACTGCCACGCCCCGGACCAGCAGCTTGGGGACCC
TCCAGGGTACTAATGGGGCTCTGTTCTGAGATGGACAAATTCAGTGTTGGAAATACATGTTGTACTATGCACTTCCCATGCTCCTAGGGT
TAGGAATAGTTTCAAACATGATTGGCAGACATAACAACGGCAAATACTCGGACTGGGGCATAGGACTCCAGAGTAGGAAAAAGACAAAAG
ATTTGGCAGCCTGACACAGGCAACCTACCCCTCTCTCTCCAGCCTCTTTATGAAACTGTTTGTTTGCCAGTCCTGCCCTAAGGCAGAAGA
TGAATTGAAGATGCTGTGCATGTTTCCTAAGTCCTTGAGCAATCATGGTGGTGACAATTGCCACAAGGGATATGAGGCCAGTGCCACCAG
AGGGTGGTGCCAAGTGCCACATCCCTTCCGATCCATTCCCCTCTGCATCCTCGGAGCACCCCAGTTTGCCTTTGATGTGTCCGCTGTGTA
TGTTAGCTGAACTTTGATGAGCAAAATTTCCTGAGCGAAACACTCCAAAGAGATAGGAAAACTTGCCGCCTCTTCTTTTTTGTCCCTTAA
TCAAACTCAAATAAGCTTAAAAAAAATCCATGGAAGATCATGGACATGTGAAATGAGCATTTTTTTCTTTTTTTTTTTTAACAAAGTCTG
AACTGAACAGAACAAGACTTTTTCCTCATACATCTCCAAATTGTTTAAACTTACTTTATGAGTGTTTGTTTAGAAGTTCGGACCAACAGA
AAAATGCAGTCAGATGTCATCTTGGAATTGGTTTCTAAAAGAGTAAGGCATGTCCCTGCCCAGAAACTTAGGAAGCATGAAATAAATCAA
ATGTTTATTTTCCTTCTTATTTAAAATCATGCAAATGCAACAGAAATAGAGGGTTTGTGCCAAATGCTATGAACGGCCCTTTCTTAAAGA
CAAGCAAGGGAGATTGATATATGTACAATTTGCTCTCATGTTTTAAAAAAAAAAAGGTAAATGTAACTTAATAGTTTTGTAAATGGGAGA

>92382_92382_1_TMPRSS2-GRHL2_TMPRSS2_chr21_42860320_ENST00000458356_GRHL2_chr8_102564942_ENST00000251808_length(amino acids)=568AA_BP=15
MACHTAPAGRTRIGVVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESS
AIIPVSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEE
YMYDQTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTA
KQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFC
DKGAERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGG
SVLVKRMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNI

--------------------------------------------------------------
>92382_92382_2_TMPRSS2-GRHL2_TMPRSS2_chr21_42860320_ENST00000458356_GRHL2_chr8_102564942_ENST00000395927_length(transcript)=2386nt_BP=534nt
GTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGA
TGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCA
CTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTT
CCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCC
TGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCG
ACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGGTTCCT
CGAGACAAGAGGCTGCTGTCTGTAAGCAAAGCAAGTGACAGCCAAGAAGACCAGGAGAAAAGAAACTGCCTTGGCACCAGTGAAGCCCAG
AGTAATTTGAGTGGAGGAGAAAACCGAGTGCAAGTCCTAAAGACTGTTCCAGTGAACCTTTCCCTAAATCAAGATCACCTGGAGAATTCC
AAGCGGGAACAGTACAGCATCAGCTTCCCCGAGAGCTCTGCCATCATCCCGGTGTCGGGAATCACGGTGGTGAAAGCTGAAGATTTCACA
CCAGTTTTCATGGCCCCACCTGTGCACTATCCCCGGGGAGATGGGGAAGAGCAACGAGTGGTTATCTTTGAACAGACTCAGTATGACGTG
CCCTCGCTGGCCACCCACAGCGCCTATCTCAAAGACGACCAGCGCAGCACTCCGGACAGCACATACAGCGAGAGCTTCAAGGACGCAGCC
ACAGAGAAATTTCGGAGTGCTTCAGTTGGGGCTGAGGAGTACATGTATGATCAGACATCAAGTGGCACATTTCAGTACACCCTGGAAGCC
ACCAAATCTCTCCGTCAGAAGCAGGGGGAGGGCCCCATGACCTACCTCAACAAAGGACAGTTCTATGCCATAACACTCAGCGAGACCGGA
GACAACAAATGCTTCCGACACCCCATCAGCAAAGTCAGGAGTGTGGTGATGGTGGTCTTCAGTGAAGACAAAAACAGAGATGAACAGCTC
AAATACTGGAAATACTGGCACTCTCGGCAGCATACGGCGAAGCAGAGGGTCCTTGACATTGCCGATTACAAGGAGAGCTTTAATACGATT
GGAAACATTGAAGAGATTGCATATAATGCTGTTTCCTTTACCTGGGACGTGAATGAAGAGGCGAAGATTTTCATCACCGTGAATTGCTTG
AGCACAGATTTCTCCTCCCAAAAAGGGGTGAAAGGACTTCCTTTGATGATTCAGATTGACACATACAGTTATAACAATCGTAGCAATAAA
CCCATTCATAGAGCTTATTGCCAGATCAAGGTCTTCTGTGACAAAGGAGCAGAAAGAAAAATCCGAGATGAAGAGCGGAAGCAGAACAGG
AAGAAAGGGAAAGGCCAGGCCTCCCAAACTCAATGCAACAGCTCCTCTGATGGGAAGTTGGCTGCCATACCTTTACAGAAGAAGAGTGAC
ATCACCTACTTCAAAACCATGCCTGATCTCCACTCACAGCCAGTTCTCTTCATACCTGATGTTCACTTTGCAAACCTGCAGAGGACCGGA
CAGGTGTATTACAACACGGATGATGAACGAGAAGGTGGCAGTGTCCTTGTTAAACGGATGTTCCGGCCCATGGAAGAGGAGTTTGGTCCA
GTGCCTTCAAAGCAGATGAAAGAAGAAGGGACAAAGCGAGTGCTCTTGTACGTGAGGAAGGAGACTGACGATGTGTTCGATGCATTGATG
TTGAAGTCTCCCACAGTGAAGGGCCTGATGGAAGCGATATCTGAGAAATATGGGCTGCCCGTGGAGAAGATAGCAAAGCTTTACAAGAAA
AGCAAAAAAGGCATCTTGGTGAACATGGATGACAACATCATCGAGCACTACTCGAACGAGGACACCTTCATCCTCAACATGGAGAGCATG
GTGGAGGGCTTCAAGGTCACGCTCATGGAAATCTAGCCCTGGGTTTGGCATCCGCTTTGGCTGGAGCTCTCAGTGCGTTCCTCCCTGAGA
GAGACAGAAGCCCCAGCCCCAGAACCTGGAGACCCATCTCCCCCATCTCACAACTGCTGTTACAAGACCGTGCTGGGGAGTGGGGCAAGG

>92382_92382_2_TMPRSS2-GRHL2_TMPRSS2_chr21_42860320_ENST00000458356_GRHL2_chr8_102564942_ENST00000395927_length(amino acids)=568AA_BP=15
MACHTAPAGRTRIGVVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESS
AIIPVSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEE
YMYDQTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTA
KQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFC
DKGAERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGG
SVLVKRMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNI

--------------------------------------------------------------
>92382_92382_3_TMPRSS2-GRHL2_TMPRSS2_chr21_42860321_ENST00000458356_GRHL2_chr8_102564943_ENST00000251808_length(transcript)=5219nt_BP=534nt
GTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGA
TGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCA
CTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTT
CCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCC
TGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCG
ACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGGTTCCT
CGAGACAAGAGGCTGCTGTCTGTAAGCAAAGCAAGTGACAGCCAAGAAGACCAGGAGAAAAGAAACTGCCTTGGCACCAGTGAAGCCCAG
AGTAATTTGAGTGGAGGAGAAAACCGAGTGCAAGTCCTAAAGACTGTTCCAGTGAACCTTTCCCTAAATCAAGATCACCTGGAGAATTCC
AAGCGGGAACAGTACAGCATCAGCTTCCCCGAGAGCTCTGCCATCATCCCGGTGTCGGGAATCACGGTGGTGAAAGCTGAAGATTTCACA
CCAGTTTTCATGGCCCCACCTGTGCACTATCCCCGGGGAGATGGGGAAGAGCAACGAGTGGTTATCTTTGAACAGACTCAGTATGACGTG
CCCTCGCTGGCCACCCACAGCGCCTATCTCAAAGACGACCAGCGCAGCACTCCGGACAGCACATACAGCGAGAGCTTCAAGGACGCAGCC
ACAGAGAAATTTCGGAGTGCTTCAGTTGGGGCTGAGGAGTACATGTATGATCAGACATCAAGTGGCACATTTCAGTACACCCTGGAAGCC
ACCAAATCTCTCCGTCAGAAGCAGGGGGAGGGCCCCATGACCTACCTCAACAAAGGACAGTTCTATGCCATAACACTCAGCGAGACCGGA
GACAACAAATGCTTCCGACACCCCATCAGCAAAGTCAGGAGTGTGGTGATGGTGGTCTTCAGTGAAGACAAAAACAGAGATGAACAGCTC
AAATACTGGAAATACTGGCACTCTCGGCAGCATACGGCGAAGCAGAGGGTCCTTGACATTGCCGATTACAAGGAGAGCTTTAATACGATT
GGAAACATTGAAGAGATTGCATATAATGCTGTTTCCTTTACCTGGGACGTGAATGAAGAGGCGAAGATTTTCATCACCGTGAATTGCTTG
AGCACAGATTTCTCCTCCCAAAAAGGGGTGAAAGGACTTCCTTTGATGATTCAGATTGACACATACAGTTATAACAATCGTAGCAATAAA
CCCATTCATAGAGCTTATTGCCAGATCAAGGTCTTCTGTGACAAAGGAGCAGAAAGAAAAATCCGAGATGAAGAGCGGAAGCAGAACAGG
AAGAAAGGGAAAGGCCAGGCCTCCCAAACTCAATGCAACAGCTCCTCTGATGGGAAGTTGGCTGCCATACCTTTACAGAAGAAGAGTGAC
ATCACCTACTTCAAAACCATGCCTGATCTCCACTCACAGCCAGTTCTCTTCATACCTGATGTTCACTTTGCAAACCTGCAGAGGACCGGA
CAGGTGTATTACAACACGGATGATGAACGAGAAGGTGGCAGTGTCCTTGTTAAACGGATGTTCCGGCCCATGGAAGAGGAGTTTGGTCCA
GTGCCTTCAAAGCAGATGAAAGAAGAAGGGACAAAGCGAGTGCTCTTGTACGTGAGGAAGGAGACTGACGATGTGTTCGATGCATTGATG
TTGAAGTCTCCCACAGTGAAGGGCCTGATGGAAGCGATATCTGAGAAATATGGGCTGCCCGTGGAGAAGATAGCAAAGCTTTACAAGAAA
AGCAAAAAAGGCATCTTGGTGAACATGGATGACAACATCATCGAGCACTACTCGAACGAGGACACCTTCATCCTCAACATGGAGAGCATG
GTGGAGGGCTTCAAGGTCACGCTCATGGAAATCTAGCCCTGGGTTTGGCATCCGCTTTGGCTGGAGCTCTCAGTGCGTTCCTCCCTGAGA
GAGACAGAAGCCCCAGCCCCAGAACCTGGAGACCCATCTCCCCCATCTCACAACTGCTGTTACAAGACCGTGCTGGGGAGTGGGGCAAGG
GACAGGCCCCACTGTCGGTGTGCTTGGCCCATCCACTGGCACCTACCACGGAGCTGAAGCCTGAGCCCCTCAGGAAGGTGCCTTAGGCCT
GTTGGATTCCTATTTATTGCCCACCTTTTCCTGGAGCCCAGGTCCAGGCCCGCCAGGACTCTGCAGGTCACTGCTAGCTCCAGATGAGAC
CGTCCAGCGTTCCCCCTTCAAGAGAAACACTCATCCCGAACAGCCTAAAAAATTCCCATCCCTTCTCTCTCACCCCTCCATATCTATCTC
CCGAGTGGCTGGACAAAATGAGCTACGTCTGGGTGCAGTAGTTATAGGTGGGGCAAGAGGTGGATGCCCACTTTCTGGTCAGACACCTTT
AGGTTGCTCTGGGGAAGGCTGTCTTGCTAAATACCTCCAGGGTTCCCAGCAAGTGGCCACCAGGCCTTGTACAGGAAGACATTCAGTCAC
CGTGTAATTAGTAACACAGAAAGTCTGCCTGTCTGCATTGTACATAGTGTTTATAATATTGTAATAATATATTTTACCTGTGGTATGTGG
GCATGTTTACTGCCACTGGCCTAGAGGAGACACAGACCTGGAGACCGTTTTAATGGGGGTTTTTGCCTCTGTGCCTGTTCAAGAGACTTG
CAGGGCTAGGTAGAGGGCCTTTGGGATGTTAAGGTGACTGCAGCTGATGCCAAGATGGACTCTGCAATGGGCATACCTGGGGGCTCGTTC
CCTGTCCCCAGAGGAAGCCCCCTCTCCTTCTCCATGGGCATGACTCTCCTTCGAGGCCACCACGTTTATCTCACAATGATGTGTTTTGCT
TGACTTTCCCTTTGCGCTGTCTCGTGGGAAAGGTCATTCTGTCTGAGACCCCAGCTCCTTCTCCAGCTTTGGCTGCGGGCATGGCCTGAG
CTTTCTGGAGAGCCTCTGCAGGGGGTTTGCCATCAGGGCCCTGTGGCTGGGTCTGCTGCAGAGCTCCTTGGCTATCAGGAGAATCCTGGA
CACTGTACTGTGCCTCCCAGTTTACAAACACGCCCTTCATCTCAAGTGGCCCTTTAAAAGGCCTGCTGCCATGTGAGAGCTGTGAACAGC
TCAGCTCTGAGTCGGCAGGCTGGGGCTTCCTCCTGGGCCACCAGATGGAAAGGGGGTATTGTTTGCCTCACTCCTGGATGCTGCGTTTTA
AGGAAGTGAGTGAGAAAGAATGTGCCAAGATACCTGGCTCCTGTGAAACCAGCCTCAGGAGGGAAACTGGGAGAGAGAAGCTGTGGTCTC
CTGCTACATGCCCTGGGAGCTGGAAGAGAAAAACACTCCCCTAAACAATCGCAAAATGATGAACCATCATGGGCCACTGTTCTCTTTGAG
GGGACAGGTTTAGGGGTTTGCGTTCGCCCTTGTGGGCTGAAGCACTAGCTTTTTGGTAGCTAGACACATCCTGCACCCAAAGGTTCTCTA
CAAAGGCCCAGATTTGTTTGTAAAGCACTTTGACTCTTACCTGGAGGCCCGCTCTCTAAGGGCTTCCTGCGCTCCCACCTCATCTGTCCC
TGAGATGCAGAGCAGGATGGAGGGTCTGCTTCTAGCTCAGCTGTTTCTCCTTGAGGTTGCGGAGGAATTGAATTGAATGGGACAGAGGGC
AGGTGCTGTGGCCAAGAAGATCTCCGAGCAGCAGTGACGGGGCACCTTGCTGTGTGTCCTCTGGGCATGTTAACCCTTCTGTGGGGCCAA
AGGTTTGCATCGTGGATCCAGCTGTGCTCCAGTCTGTCCCCTCCTCCTCCACTCTGACTGCCACGCCCCGGACCAGCAGCTTGGGGACCC
TCCAGGGTACTAATGGGGCTCTGTTCTGAGATGGACAAATTCAGTGTTGGAAATACATGTTGTACTATGCACTTCCCATGCTCCTAGGGT
TAGGAATAGTTTCAAACATGATTGGCAGACATAACAACGGCAAATACTCGGACTGGGGCATAGGACTCCAGAGTAGGAAAAAGACAAAAG
ATTTGGCAGCCTGACACAGGCAACCTACCCCTCTCTCTCCAGCCTCTTTATGAAACTGTTTGTTTGCCAGTCCTGCCCTAAGGCAGAAGA
TGAATTGAAGATGCTGTGCATGTTTCCTAAGTCCTTGAGCAATCATGGTGGTGACAATTGCCACAAGGGATATGAGGCCAGTGCCACCAG
AGGGTGGTGCCAAGTGCCACATCCCTTCCGATCCATTCCCCTCTGCATCCTCGGAGCACCCCAGTTTGCCTTTGATGTGTCCGCTGTGTA
TGTTAGCTGAACTTTGATGAGCAAAATTTCCTGAGCGAAACACTCCAAAGAGATAGGAAAACTTGCCGCCTCTTCTTTTTTGTCCCTTAA
TCAAACTCAAATAAGCTTAAAAAAAATCCATGGAAGATCATGGACATGTGAAATGAGCATTTTTTTCTTTTTTTTTTTTAACAAAGTCTG
AACTGAACAGAACAAGACTTTTTCCTCATACATCTCCAAATTGTTTAAACTTACTTTATGAGTGTTTGTTTAGAAGTTCGGACCAACAGA
AAAATGCAGTCAGATGTCATCTTGGAATTGGTTTCTAAAAGAGTAAGGCATGTCCCTGCCCAGAAACTTAGGAAGCATGAAATAAATCAA
ATGTTTATTTTCCTTCTTATTTAAAATCATGCAAATGCAACAGAAATAGAGGGTTTGTGCCAAATGCTATGAACGGCCCTTTCTTAAAGA
CAAGCAAGGGAGATTGATATATGTACAATTTGCTCTCATGTTTTAAAAAAAAAAAGGTAAATGTAACTTAATAGTTTTGTAAATGGGAGA

>92382_92382_3_TMPRSS2-GRHL2_TMPRSS2_chr21_42860321_ENST00000458356_GRHL2_chr8_102564943_ENST00000251808_length(amino acids)=568AA_BP=15
MACHTAPAGRTRIGVVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESS
AIIPVSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEE
YMYDQTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTA
KQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFC
DKGAERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGG
SVLVKRMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNI

--------------------------------------------------------------
>92382_92382_4_TMPRSS2-GRHL2_TMPRSS2_chr21_42860321_ENST00000458356_GRHL2_chr8_102564943_ENST00000395927_length(transcript)=2386nt_BP=534nt
GTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGA
TGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCA
CTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTT
CCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCC
TGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCG
ACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGGTTCCT
CGAGACAAGAGGCTGCTGTCTGTAAGCAAAGCAAGTGACAGCCAAGAAGACCAGGAGAAAAGAAACTGCCTTGGCACCAGTGAAGCCCAG
AGTAATTTGAGTGGAGGAGAAAACCGAGTGCAAGTCCTAAAGACTGTTCCAGTGAACCTTTCCCTAAATCAAGATCACCTGGAGAATTCC
AAGCGGGAACAGTACAGCATCAGCTTCCCCGAGAGCTCTGCCATCATCCCGGTGTCGGGAATCACGGTGGTGAAAGCTGAAGATTTCACA
CCAGTTTTCATGGCCCCACCTGTGCACTATCCCCGGGGAGATGGGGAAGAGCAACGAGTGGTTATCTTTGAACAGACTCAGTATGACGTG
CCCTCGCTGGCCACCCACAGCGCCTATCTCAAAGACGACCAGCGCAGCACTCCGGACAGCACATACAGCGAGAGCTTCAAGGACGCAGCC
ACAGAGAAATTTCGGAGTGCTTCAGTTGGGGCTGAGGAGTACATGTATGATCAGACATCAAGTGGCACATTTCAGTACACCCTGGAAGCC
ACCAAATCTCTCCGTCAGAAGCAGGGGGAGGGCCCCATGACCTACCTCAACAAAGGACAGTTCTATGCCATAACACTCAGCGAGACCGGA
GACAACAAATGCTTCCGACACCCCATCAGCAAAGTCAGGAGTGTGGTGATGGTGGTCTTCAGTGAAGACAAAAACAGAGATGAACAGCTC
AAATACTGGAAATACTGGCACTCTCGGCAGCATACGGCGAAGCAGAGGGTCCTTGACATTGCCGATTACAAGGAGAGCTTTAATACGATT
GGAAACATTGAAGAGATTGCATATAATGCTGTTTCCTTTACCTGGGACGTGAATGAAGAGGCGAAGATTTTCATCACCGTGAATTGCTTG
AGCACAGATTTCTCCTCCCAAAAAGGGGTGAAAGGACTTCCTTTGATGATTCAGATTGACACATACAGTTATAACAATCGTAGCAATAAA
CCCATTCATAGAGCTTATTGCCAGATCAAGGTCTTCTGTGACAAAGGAGCAGAAAGAAAAATCCGAGATGAAGAGCGGAAGCAGAACAGG
AAGAAAGGGAAAGGCCAGGCCTCCCAAACTCAATGCAACAGCTCCTCTGATGGGAAGTTGGCTGCCATACCTTTACAGAAGAAGAGTGAC
ATCACCTACTTCAAAACCATGCCTGATCTCCACTCACAGCCAGTTCTCTTCATACCTGATGTTCACTTTGCAAACCTGCAGAGGACCGGA
CAGGTGTATTACAACACGGATGATGAACGAGAAGGTGGCAGTGTCCTTGTTAAACGGATGTTCCGGCCCATGGAAGAGGAGTTTGGTCCA
GTGCCTTCAAAGCAGATGAAAGAAGAAGGGACAAAGCGAGTGCTCTTGTACGTGAGGAAGGAGACTGACGATGTGTTCGATGCATTGATG
TTGAAGTCTCCCACAGTGAAGGGCCTGATGGAAGCGATATCTGAGAAATATGGGCTGCCCGTGGAGAAGATAGCAAAGCTTTACAAGAAA
AGCAAAAAAGGCATCTTGGTGAACATGGATGACAACATCATCGAGCACTACTCGAACGAGGACACCTTCATCCTCAACATGGAGAGCATG
GTGGAGGGCTTCAAGGTCACGCTCATGGAAATCTAGCCCTGGGTTTGGCATCCGCTTTGGCTGGAGCTCTCAGTGCGTTCCTCCCTGAGA
GAGACAGAAGCCCCAGCCCCAGAACCTGGAGACCCATCTCCCCCATCTCACAACTGCTGTTACAAGACCGTGCTGGGGAGTGGGGCAAGG

>92382_92382_4_TMPRSS2-GRHL2_TMPRSS2_chr21_42860321_ENST00000458356_GRHL2_chr8_102564943_ENST00000395927_length(amino acids)=568AA_BP=15
MACHTAPAGRTRIGVVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESS
AIIPVSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEE
YMYDQTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTA
KQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFC
DKGAERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGG
SVLVKRMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNI

--------------------------------------------------------------
>92382_92382_5_TMPRSS2-GRHL2_TMPRSS2_chr21_42861433_ENST00000458356_GRHL2_chr8_102564942_ENST00000251808_length(transcript)=5099nt_BP=414nt
GTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGA
TGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCA
CTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTT
CCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCC
TGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCAGTTCCTCGAGACAAGAGGCTGCTGTCTGTAAGCAAA
GCAAGTGACAGCCAAGAAGACCAGGAGAAAAGAAACTGCCTTGGCACCAGTGAAGCCCAGAGTAATTTGAGTGGAGGAGAAAACCGAGTG
CAAGTCCTAAAGACTGTTCCAGTGAACCTTTCCCTAAATCAAGATCACCTGGAGAATTCCAAGCGGGAACAGTACAGCATCAGCTTCCCC
GAGAGCTCTGCCATCATCCCGGTGTCGGGAATCACGGTGGTGAAAGCTGAAGATTTCACACCAGTTTTCATGGCCCCACCTGTGCACTAT
CCCCGGGGAGATGGGGAAGAGCAACGAGTGGTTATCTTTGAACAGACTCAGTATGACGTGCCCTCGCTGGCCACCCACAGCGCCTATCTC
AAAGACGACCAGCGCAGCACTCCGGACAGCACATACAGCGAGAGCTTCAAGGACGCAGCCACAGAGAAATTTCGGAGTGCTTCAGTTGGG
GCTGAGGAGTACATGTATGATCAGACATCAAGTGGCACATTTCAGTACACCCTGGAAGCCACCAAATCTCTCCGTCAGAAGCAGGGGGAG
GGCCCCATGACCTACCTCAACAAAGGACAGTTCTATGCCATAACACTCAGCGAGACCGGAGACAACAAATGCTTCCGACACCCCATCAGC
AAAGTCAGGAGTGTGGTGATGGTGGTCTTCAGTGAAGACAAAAACAGAGATGAACAGCTCAAATACTGGAAATACTGGCACTCTCGGCAG
CATACGGCGAAGCAGAGGGTCCTTGACATTGCCGATTACAAGGAGAGCTTTAATACGATTGGAAACATTGAAGAGATTGCATATAATGCT
GTTTCCTTTACCTGGGACGTGAATGAAGAGGCGAAGATTTTCATCACCGTGAATTGCTTGAGCACAGATTTCTCCTCCCAAAAAGGGGTG
AAAGGACTTCCTTTGATGATTCAGATTGACACATACAGTTATAACAATCGTAGCAATAAACCCATTCATAGAGCTTATTGCCAGATCAAG
GTCTTCTGTGACAAAGGAGCAGAAAGAAAAATCCGAGATGAAGAGCGGAAGCAGAACAGGAAGAAAGGGAAAGGCCAGGCCTCCCAAACT
CAATGCAACAGCTCCTCTGATGGGAAGTTGGCTGCCATACCTTTACAGAAGAAGAGTGACATCACCTACTTCAAAACCATGCCTGATCTC
CACTCACAGCCAGTTCTCTTCATACCTGATGTTCACTTTGCAAACCTGCAGAGGACCGGACAGGTGTATTACAACACGGATGATGAACGA
GAAGGTGGCAGTGTCCTTGTTAAACGGATGTTCCGGCCCATGGAAGAGGAGTTTGGTCCAGTGCCTTCAAAGCAGATGAAAGAAGAAGGG
ACAAAGCGAGTGCTCTTGTACGTGAGGAAGGAGACTGACGATGTGTTCGATGCATTGATGTTGAAGTCTCCCACAGTGAAGGGCCTGATG
GAAGCGATATCTGAGAAATATGGGCTGCCCGTGGAGAAGATAGCAAAGCTTTACAAGAAAAGCAAAAAAGGCATCTTGGTGAACATGGAT
GACAACATCATCGAGCACTACTCGAACGAGGACACCTTCATCCTCAACATGGAGAGCATGGTGGAGGGCTTCAAGGTCACGCTCATGGAA
ATCTAGCCCTGGGTTTGGCATCCGCTTTGGCTGGAGCTCTCAGTGCGTTCCTCCCTGAGAGAGACAGAAGCCCCAGCCCCAGAACCTGGA
GACCCATCTCCCCCATCTCACAACTGCTGTTACAAGACCGTGCTGGGGAGTGGGGCAAGGGACAGGCCCCACTGTCGGTGTGCTTGGCCC
ATCCACTGGCACCTACCACGGAGCTGAAGCCTGAGCCCCTCAGGAAGGTGCCTTAGGCCTGTTGGATTCCTATTTATTGCCCACCTTTTC
CTGGAGCCCAGGTCCAGGCCCGCCAGGACTCTGCAGGTCACTGCTAGCTCCAGATGAGACCGTCCAGCGTTCCCCCTTCAAGAGAAACAC
TCATCCCGAACAGCCTAAAAAATTCCCATCCCTTCTCTCTCACCCCTCCATATCTATCTCCCGAGTGGCTGGACAAAATGAGCTACGTCT
GGGTGCAGTAGTTATAGGTGGGGCAAGAGGTGGATGCCCACTTTCTGGTCAGACACCTTTAGGTTGCTCTGGGGAAGGCTGTCTTGCTAA
ATACCTCCAGGGTTCCCAGCAAGTGGCCACCAGGCCTTGTACAGGAAGACATTCAGTCACCGTGTAATTAGTAACACAGAAAGTCTGCCT
GTCTGCATTGTACATAGTGTTTATAATATTGTAATAATATATTTTACCTGTGGTATGTGGGCATGTTTACTGCCACTGGCCTAGAGGAGA
CACAGACCTGGAGACCGTTTTAATGGGGGTTTTTGCCTCTGTGCCTGTTCAAGAGACTTGCAGGGCTAGGTAGAGGGCCTTTGGGATGTT
AAGGTGACTGCAGCTGATGCCAAGATGGACTCTGCAATGGGCATACCTGGGGGCTCGTTCCCTGTCCCCAGAGGAAGCCCCCTCTCCTTC
TCCATGGGCATGACTCTCCTTCGAGGCCACCACGTTTATCTCACAATGATGTGTTTTGCTTGACTTTCCCTTTGCGCTGTCTCGTGGGAA
AGGTCATTCTGTCTGAGACCCCAGCTCCTTCTCCAGCTTTGGCTGCGGGCATGGCCTGAGCTTTCTGGAGAGCCTCTGCAGGGGGTTTGC
CATCAGGGCCCTGTGGCTGGGTCTGCTGCAGAGCTCCTTGGCTATCAGGAGAATCCTGGACACTGTACTGTGCCTCCCAGTTTACAAACA
CGCCCTTCATCTCAAGTGGCCCTTTAAAAGGCCTGCTGCCATGTGAGAGCTGTGAACAGCTCAGCTCTGAGTCGGCAGGCTGGGGCTTCC
TCCTGGGCCACCAGATGGAAAGGGGGTATTGTTTGCCTCACTCCTGGATGCTGCGTTTTAAGGAAGTGAGTGAGAAAGAATGTGCCAAGA
TACCTGGCTCCTGTGAAACCAGCCTCAGGAGGGAAACTGGGAGAGAGAAGCTGTGGTCTCCTGCTACATGCCCTGGGAGCTGGAAGAGAA
AAACACTCCCCTAAACAATCGCAAAATGATGAACCATCATGGGCCACTGTTCTCTTTGAGGGGACAGGTTTAGGGGTTTGCGTTCGCCCT
TGTGGGCTGAAGCACTAGCTTTTTGGTAGCTAGACACATCCTGCACCCAAAGGTTCTCTACAAAGGCCCAGATTTGTTTGTAAAGCACTT
TGACTCTTACCTGGAGGCCCGCTCTCTAAGGGCTTCCTGCGCTCCCACCTCATCTGTCCCTGAGATGCAGAGCAGGATGGAGGGTCTGCT
TCTAGCTCAGCTGTTTCTCCTTGAGGTTGCGGAGGAATTGAATTGAATGGGACAGAGGGCAGGTGCTGTGGCCAAGAAGATCTCCGAGCA
GCAGTGACGGGGCACCTTGCTGTGTGTCCTCTGGGCATGTTAACCCTTCTGTGGGGCCAAAGGTTTGCATCGTGGATCCAGCTGTGCTCC
AGTCTGTCCCCTCCTCCTCCACTCTGACTGCCACGCCCCGGACCAGCAGCTTGGGGACCCTCCAGGGTACTAATGGGGCTCTGTTCTGAG
ATGGACAAATTCAGTGTTGGAAATACATGTTGTACTATGCACTTCCCATGCTCCTAGGGTTAGGAATAGTTTCAAACATGATTGGCAGAC
ATAACAACGGCAAATACTCGGACTGGGGCATAGGACTCCAGAGTAGGAAAAAGACAAAAGATTTGGCAGCCTGACACAGGCAACCTACCC
CTCTCTCTCCAGCCTCTTTATGAAACTGTTTGTTTGCCAGTCCTGCCCTAAGGCAGAAGATGAATTGAAGATGCTGTGCATGTTTCCTAA
GTCCTTGAGCAATCATGGTGGTGACAATTGCCACAAGGGATATGAGGCCAGTGCCACCAGAGGGTGGTGCCAAGTGCCACATCCCTTCCG
ATCCATTCCCCTCTGCATCCTCGGAGCACCCCAGTTTGCCTTTGATGTGTCCGCTGTGTATGTTAGCTGAACTTTGATGAGCAAAATTTC
CTGAGCGAAACACTCCAAAGAGATAGGAAAACTTGCCGCCTCTTCTTTTTTGTCCCTTAATCAAACTCAAATAAGCTTAAAAAAAATCCA
TGGAAGATCATGGACATGTGAAATGAGCATTTTTTTCTTTTTTTTTTTTAACAAAGTCTGAACTGAACAGAACAAGACTTTTTCCTCATA
CATCTCCAAATTGTTTAAACTTACTTTATGAGTGTTTGTTTAGAAGTTCGGACCAACAGAAAAATGCAGTCAGATGTCATCTTGGAATTG
GTTTCTAAAAGAGTAAGGCATGTCCCTGCCCAGAAACTTAGGAAGCATGAAATAAATCAAATGTTTATTTTCCTTCTTATTTAAAATCAT
GCAAATGCAACAGAAATAGAGGGTTTGTGCCAAATGCTATGAACGGCCCTTTCTTAAAGACAAGCAAGGGAGATTGATATATGTACAATT
TGCTCTCATGTTTTAAAAAAAAAAAGGTAAATGTAACTTAATAGTTTTGTAAATGGGAGAGGGGGAATCTATAAACTATAAATACAGTTA

>92382_92382_5_TMPRSS2-GRHL2_TMPRSS2_chr21_42861433_ENST00000458356_GRHL2_chr8_102564942_ENST00000251808_length(amino acids)=564AA_BP=11
MRWPLAYSGSSVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESSAIIP
VSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMYD
QTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRV
LDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGA
ERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGGSVLV
KRMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEHY

--------------------------------------------------------------
>92382_92382_6_TMPRSS2-GRHL2_TMPRSS2_chr21_42861433_ENST00000458356_GRHL2_chr8_102564942_ENST00000395927_length(transcript)=2266nt_BP=414nt
GTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGA
TGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCA
CTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTT
CCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCC
TGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCAGTTCCTCGAGACAAGAGGCTGCTGTCTGTAAGCAAA
GCAAGTGACAGCCAAGAAGACCAGGAGAAAAGAAACTGCCTTGGCACCAGTGAAGCCCAGAGTAATTTGAGTGGAGGAGAAAACCGAGTG
CAAGTCCTAAAGACTGTTCCAGTGAACCTTTCCCTAAATCAAGATCACCTGGAGAATTCCAAGCGGGAACAGTACAGCATCAGCTTCCCC
GAGAGCTCTGCCATCATCCCGGTGTCGGGAATCACGGTGGTGAAAGCTGAAGATTTCACACCAGTTTTCATGGCCCCACCTGTGCACTAT
CCCCGGGGAGATGGGGAAGAGCAACGAGTGGTTATCTTTGAACAGACTCAGTATGACGTGCCCTCGCTGGCCACCCACAGCGCCTATCTC
AAAGACGACCAGCGCAGCACTCCGGACAGCACATACAGCGAGAGCTTCAAGGACGCAGCCACAGAGAAATTTCGGAGTGCTTCAGTTGGG
GCTGAGGAGTACATGTATGATCAGACATCAAGTGGCACATTTCAGTACACCCTGGAAGCCACCAAATCTCTCCGTCAGAAGCAGGGGGAG
GGCCCCATGACCTACCTCAACAAAGGACAGTTCTATGCCATAACACTCAGCGAGACCGGAGACAACAAATGCTTCCGACACCCCATCAGC
AAAGTCAGGAGTGTGGTGATGGTGGTCTTCAGTGAAGACAAAAACAGAGATGAACAGCTCAAATACTGGAAATACTGGCACTCTCGGCAG
CATACGGCGAAGCAGAGGGTCCTTGACATTGCCGATTACAAGGAGAGCTTTAATACGATTGGAAACATTGAAGAGATTGCATATAATGCT
GTTTCCTTTACCTGGGACGTGAATGAAGAGGCGAAGATTTTCATCACCGTGAATTGCTTGAGCACAGATTTCTCCTCCCAAAAAGGGGTG
AAAGGACTTCCTTTGATGATTCAGATTGACACATACAGTTATAACAATCGTAGCAATAAACCCATTCATAGAGCTTATTGCCAGATCAAG
GTCTTCTGTGACAAAGGAGCAGAAAGAAAAATCCGAGATGAAGAGCGGAAGCAGAACAGGAAGAAAGGGAAAGGCCAGGCCTCCCAAACT
CAATGCAACAGCTCCTCTGATGGGAAGTTGGCTGCCATACCTTTACAGAAGAAGAGTGACATCACCTACTTCAAAACCATGCCTGATCTC
CACTCACAGCCAGTTCTCTTCATACCTGATGTTCACTTTGCAAACCTGCAGAGGACCGGACAGGTGTATTACAACACGGATGATGAACGA
GAAGGTGGCAGTGTCCTTGTTAAACGGATGTTCCGGCCCATGGAAGAGGAGTTTGGTCCAGTGCCTTCAAAGCAGATGAAAGAAGAAGGG
ACAAAGCGAGTGCTCTTGTACGTGAGGAAGGAGACTGACGATGTGTTCGATGCATTGATGTTGAAGTCTCCCACAGTGAAGGGCCTGATG
GAAGCGATATCTGAGAAATATGGGCTGCCCGTGGAGAAGATAGCAAAGCTTTACAAGAAAAGCAAAAAAGGCATCTTGGTGAACATGGAT
GACAACATCATCGAGCACTACTCGAACGAGGACACCTTCATCCTCAACATGGAGAGCATGGTGGAGGGCTTCAAGGTCACGCTCATGGAA
ATCTAGCCCTGGGTTTGGCATCCGCTTTGGCTGGAGCTCTCAGTGCGTTCCTCCCTGAGAGAGACAGAAGCCCCAGCCCCAGAACCTGGA
GACCCATCTCCCCCATCTCACAACTGCTGTTACAAGACCGTGCTGGGGAGTGGGGCAAGGGACAGGCCCCACTGTCGGTGTGCTTGGCCC

>92382_92382_6_TMPRSS2-GRHL2_TMPRSS2_chr21_42861433_ENST00000458356_GRHL2_chr8_102564942_ENST00000395927_length(amino acids)=564AA_BP=11
MRWPLAYSGSSVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESSAIIP
VSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMYD
QTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRV
LDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGA
ERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGGSVLV
KRMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEHY

--------------------------------------------------------------
>92382_92382_7_TMPRSS2-GRHL2_TMPRSS2_chr21_42861434_ENST00000458356_GRHL2_chr8_102564943_ENST00000251808_length(transcript)=5099nt_BP=414nt
GTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGA
TGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCA
CTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTT
CCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCC
TGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCAGTTCCTCGAGACAAGAGGCTGCTGTCTGTAAGCAAA
GCAAGTGACAGCCAAGAAGACCAGGAGAAAAGAAACTGCCTTGGCACCAGTGAAGCCCAGAGTAATTTGAGTGGAGGAGAAAACCGAGTG
CAAGTCCTAAAGACTGTTCCAGTGAACCTTTCCCTAAATCAAGATCACCTGGAGAATTCCAAGCGGGAACAGTACAGCATCAGCTTCCCC
GAGAGCTCTGCCATCATCCCGGTGTCGGGAATCACGGTGGTGAAAGCTGAAGATTTCACACCAGTTTTCATGGCCCCACCTGTGCACTAT
CCCCGGGGAGATGGGGAAGAGCAACGAGTGGTTATCTTTGAACAGACTCAGTATGACGTGCCCTCGCTGGCCACCCACAGCGCCTATCTC
AAAGACGACCAGCGCAGCACTCCGGACAGCACATACAGCGAGAGCTTCAAGGACGCAGCCACAGAGAAATTTCGGAGTGCTTCAGTTGGG
GCTGAGGAGTACATGTATGATCAGACATCAAGTGGCACATTTCAGTACACCCTGGAAGCCACCAAATCTCTCCGTCAGAAGCAGGGGGAG
GGCCCCATGACCTACCTCAACAAAGGACAGTTCTATGCCATAACACTCAGCGAGACCGGAGACAACAAATGCTTCCGACACCCCATCAGC
AAAGTCAGGAGTGTGGTGATGGTGGTCTTCAGTGAAGACAAAAACAGAGATGAACAGCTCAAATACTGGAAATACTGGCACTCTCGGCAG
CATACGGCGAAGCAGAGGGTCCTTGACATTGCCGATTACAAGGAGAGCTTTAATACGATTGGAAACATTGAAGAGATTGCATATAATGCT
GTTTCCTTTACCTGGGACGTGAATGAAGAGGCGAAGATTTTCATCACCGTGAATTGCTTGAGCACAGATTTCTCCTCCCAAAAAGGGGTG
AAAGGACTTCCTTTGATGATTCAGATTGACACATACAGTTATAACAATCGTAGCAATAAACCCATTCATAGAGCTTATTGCCAGATCAAG
GTCTTCTGTGACAAAGGAGCAGAAAGAAAAATCCGAGATGAAGAGCGGAAGCAGAACAGGAAGAAAGGGAAAGGCCAGGCCTCCCAAACT
CAATGCAACAGCTCCTCTGATGGGAAGTTGGCTGCCATACCTTTACAGAAGAAGAGTGACATCACCTACTTCAAAACCATGCCTGATCTC
CACTCACAGCCAGTTCTCTTCATACCTGATGTTCACTTTGCAAACCTGCAGAGGACCGGACAGGTGTATTACAACACGGATGATGAACGA
GAAGGTGGCAGTGTCCTTGTTAAACGGATGTTCCGGCCCATGGAAGAGGAGTTTGGTCCAGTGCCTTCAAAGCAGATGAAAGAAGAAGGG
ACAAAGCGAGTGCTCTTGTACGTGAGGAAGGAGACTGACGATGTGTTCGATGCATTGATGTTGAAGTCTCCCACAGTGAAGGGCCTGATG
GAAGCGATATCTGAGAAATATGGGCTGCCCGTGGAGAAGATAGCAAAGCTTTACAAGAAAAGCAAAAAAGGCATCTTGGTGAACATGGAT
GACAACATCATCGAGCACTACTCGAACGAGGACACCTTCATCCTCAACATGGAGAGCATGGTGGAGGGCTTCAAGGTCACGCTCATGGAA
ATCTAGCCCTGGGTTTGGCATCCGCTTTGGCTGGAGCTCTCAGTGCGTTCCTCCCTGAGAGAGACAGAAGCCCCAGCCCCAGAACCTGGA
GACCCATCTCCCCCATCTCACAACTGCTGTTACAAGACCGTGCTGGGGAGTGGGGCAAGGGACAGGCCCCACTGTCGGTGTGCTTGGCCC
ATCCACTGGCACCTACCACGGAGCTGAAGCCTGAGCCCCTCAGGAAGGTGCCTTAGGCCTGTTGGATTCCTATTTATTGCCCACCTTTTC
CTGGAGCCCAGGTCCAGGCCCGCCAGGACTCTGCAGGTCACTGCTAGCTCCAGATGAGACCGTCCAGCGTTCCCCCTTCAAGAGAAACAC
TCATCCCGAACAGCCTAAAAAATTCCCATCCCTTCTCTCTCACCCCTCCATATCTATCTCCCGAGTGGCTGGACAAAATGAGCTACGTCT
GGGTGCAGTAGTTATAGGTGGGGCAAGAGGTGGATGCCCACTTTCTGGTCAGACACCTTTAGGTTGCTCTGGGGAAGGCTGTCTTGCTAA
ATACCTCCAGGGTTCCCAGCAAGTGGCCACCAGGCCTTGTACAGGAAGACATTCAGTCACCGTGTAATTAGTAACACAGAAAGTCTGCCT
GTCTGCATTGTACATAGTGTTTATAATATTGTAATAATATATTTTACCTGTGGTATGTGGGCATGTTTACTGCCACTGGCCTAGAGGAGA
CACAGACCTGGAGACCGTTTTAATGGGGGTTTTTGCCTCTGTGCCTGTTCAAGAGACTTGCAGGGCTAGGTAGAGGGCCTTTGGGATGTT
AAGGTGACTGCAGCTGATGCCAAGATGGACTCTGCAATGGGCATACCTGGGGGCTCGTTCCCTGTCCCCAGAGGAAGCCCCCTCTCCTTC
TCCATGGGCATGACTCTCCTTCGAGGCCACCACGTTTATCTCACAATGATGTGTTTTGCTTGACTTTCCCTTTGCGCTGTCTCGTGGGAA
AGGTCATTCTGTCTGAGACCCCAGCTCCTTCTCCAGCTTTGGCTGCGGGCATGGCCTGAGCTTTCTGGAGAGCCTCTGCAGGGGGTTTGC
CATCAGGGCCCTGTGGCTGGGTCTGCTGCAGAGCTCCTTGGCTATCAGGAGAATCCTGGACACTGTACTGTGCCTCCCAGTTTACAAACA
CGCCCTTCATCTCAAGTGGCCCTTTAAAAGGCCTGCTGCCATGTGAGAGCTGTGAACAGCTCAGCTCTGAGTCGGCAGGCTGGGGCTTCC
TCCTGGGCCACCAGATGGAAAGGGGGTATTGTTTGCCTCACTCCTGGATGCTGCGTTTTAAGGAAGTGAGTGAGAAAGAATGTGCCAAGA
TACCTGGCTCCTGTGAAACCAGCCTCAGGAGGGAAACTGGGAGAGAGAAGCTGTGGTCTCCTGCTACATGCCCTGGGAGCTGGAAGAGAA
AAACACTCCCCTAAACAATCGCAAAATGATGAACCATCATGGGCCACTGTTCTCTTTGAGGGGACAGGTTTAGGGGTTTGCGTTCGCCCT
TGTGGGCTGAAGCACTAGCTTTTTGGTAGCTAGACACATCCTGCACCCAAAGGTTCTCTACAAAGGCCCAGATTTGTTTGTAAAGCACTT
TGACTCTTACCTGGAGGCCCGCTCTCTAAGGGCTTCCTGCGCTCCCACCTCATCTGTCCCTGAGATGCAGAGCAGGATGGAGGGTCTGCT
TCTAGCTCAGCTGTTTCTCCTTGAGGTTGCGGAGGAATTGAATTGAATGGGACAGAGGGCAGGTGCTGTGGCCAAGAAGATCTCCGAGCA
GCAGTGACGGGGCACCTTGCTGTGTGTCCTCTGGGCATGTTAACCCTTCTGTGGGGCCAAAGGTTTGCATCGTGGATCCAGCTGTGCTCC
AGTCTGTCCCCTCCTCCTCCACTCTGACTGCCACGCCCCGGACCAGCAGCTTGGGGACCCTCCAGGGTACTAATGGGGCTCTGTTCTGAG
ATGGACAAATTCAGTGTTGGAAATACATGTTGTACTATGCACTTCCCATGCTCCTAGGGTTAGGAATAGTTTCAAACATGATTGGCAGAC
ATAACAACGGCAAATACTCGGACTGGGGCATAGGACTCCAGAGTAGGAAAAAGACAAAAGATTTGGCAGCCTGACACAGGCAACCTACCC
CTCTCTCTCCAGCCTCTTTATGAAACTGTTTGTTTGCCAGTCCTGCCCTAAGGCAGAAGATGAATTGAAGATGCTGTGCATGTTTCCTAA
GTCCTTGAGCAATCATGGTGGTGACAATTGCCACAAGGGATATGAGGCCAGTGCCACCAGAGGGTGGTGCCAAGTGCCACATCCCTTCCG
ATCCATTCCCCTCTGCATCCTCGGAGCACCCCAGTTTGCCTTTGATGTGTCCGCTGTGTATGTTAGCTGAACTTTGATGAGCAAAATTTC
CTGAGCGAAACACTCCAAAGAGATAGGAAAACTTGCCGCCTCTTCTTTTTTGTCCCTTAATCAAACTCAAATAAGCTTAAAAAAAATCCA
TGGAAGATCATGGACATGTGAAATGAGCATTTTTTTCTTTTTTTTTTTTAACAAAGTCTGAACTGAACAGAACAAGACTTTTTCCTCATA
CATCTCCAAATTGTTTAAACTTACTTTATGAGTGTTTGTTTAGAAGTTCGGACCAACAGAAAAATGCAGTCAGATGTCATCTTGGAATTG
GTTTCTAAAAGAGTAAGGCATGTCCCTGCCCAGAAACTTAGGAAGCATGAAATAAATCAAATGTTTATTTTCCTTCTTATTTAAAATCAT
GCAAATGCAACAGAAATAGAGGGTTTGTGCCAAATGCTATGAACGGCCCTTTCTTAAAGACAAGCAAGGGAGATTGATATATGTACAATT
TGCTCTCATGTTTTAAAAAAAAAAAGGTAAATGTAACTTAATAGTTTTGTAAATGGGAGAGGGGGAATCTATAAACTATAAATACAGTTA

>92382_92382_7_TMPRSS2-GRHL2_TMPRSS2_chr21_42861434_ENST00000458356_GRHL2_chr8_102564943_ENST00000251808_length(amino acids)=564AA_BP=11
MRWPLAYSGSSVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESSAIIP
VSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMYD
QTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRV
LDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGA
ERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGGSVLV
KRMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEHY

--------------------------------------------------------------
>92382_92382_8_TMPRSS2-GRHL2_TMPRSS2_chr21_42861434_ENST00000458356_GRHL2_chr8_102564943_ENST00000395927_length(transcript)=2266nt_BP=414nt
GTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGA
TGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCA
CTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTT
CCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCC
TGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCAGTTCCTCGAGACAAGAGGCTGCTGTCTGTAAGCAAA
GCAAGTGACAGCCAAGAAGACCAGGAGAAAAGAAACTGCCTTGGCACCAGTGAAGCCCAGAGTAATTTGAGTGGAGGAGAAAACCGAGTG
CAAGTCCTAAAGACTGTTCCAGTGAACCTTTCCCTAAATCAAGATCACCTGGAGAATTCCAAGCGGGAACAGTACAGCATCAGCTTCCCC
GAGAGCTCTGCCATCATCCCGGTGTCGGGAATCACGGTGGTGAAAGCTGAAGATTTCACACCAGTTTTCATGGCCCCACCTGTGCACTAT
CCCCGGGGAGATGGGGAAGAGCAACGAGTGGTTATCTTTGAACAGACTCAGTATGACGTGCCCTCGCTGGCCACCCACAGCGCCTATCTC
AAAGACGACCAGCGCAGCACTCCGGACAGCACATACAGCGAGAGCTTCAAGGACGCAGCCACAGAGAAATTTCGGAGTGCTTCAGTTGGG
GCTGAGGAGTACATGTATGATCAGACATCAAGTGGCACATTTCAGTACACCCTGGAAGCCACCAAATCTCTCCGTCAGAAGCAGGGGGAG
GGCCCCATGACCTACCTCAACAAAGGACAGTTCTATGCCATAACACTCAGCGAGACCGGAGACAACAAATGCTTCCGACACCCCATCAGC
AAAGTCAGGAGTGTGGTGATGGTGGTCTTCAGTGAAGACAAAAACAGAGATGAACAGCTCAAATACTGGAAATACTGGCACTCTCGGCAG
CATACGGCGAAGCAGAGGGTCCTTGACATTGCCGATTACAAGGAGAGCTTTAATACGATTGGAAACATTGAAGAGATTGCATATAATGCT
GTTTCCTTTACCTGGGACGTGAATGAAGAGGCGAAGATTTTCATCACCGTGAATTGCTTGAGCACAGATTTCTCCTCCCAAAAAGGGGTG
AAAGGACTTCCTTTGATGATTCAGATTGACACATACAGTTATAACAATCGTAGCAATAAACCCATTCATAGAGCTTATTGCCAGATCAAG
GTCTTCTGTGACAAAGGAGCAGAAAGAAAAATCCGAGATGAAGAGCGGAAGCAGAACAGGAAGAAAGGGAAAGGCCAGGCCTCCCAAACT
CAATGCAACAGCTCCTCTGATGGGAAGTTGGCTGCCATACCTTTACAGAAGAAGAGTGACATCACCTACTTCAAAACCATGCCTGATCTC
CACTCACAGCCAGTTCTCTTCATACCTGATGTTCACTTTGCAAACCTGCAGAGGACCGGACAGGTGTATTACAACACGGATGATGAACGA
GAAGGTGGCAGTGTCCTTGTTAAACGGATGTTCCGGCCCATGGAAGAGGAGTTTGGTCCAGTGCCTTCAAAGCAGATGAAAGAAGAAGGG
ACAAAGCGAGTGCTCTTGTACGTGAGGAAGGAGACTGACGATGTGTTCGATGCATTGATGTTGAAGTCTCCCACAGTGAAGGGCCTGATG
GAAGCGATATCTGAGAAATATGGGCTGCCCGTGGAGAAGATAGCAAAGCTTTACAAGAAAAGCAAAAAAGGCATCTTGGTGAACATGGAT
GACAACATCATCGAGCACTACTCGAACGAGGACACCTTCATCCTCAACATGGAGAGCATGGTGGAGGGCTTCAAGGTCACGCTCATGGAA
ATCTAGCCCTGGGTTTGGCATCCGCTTTGGCTGGAGCTCTCAGTGCGTTCCTCCCTGAGAGAGACAGAAGCCCCAGCCCCAGAACCTGGA
GACCCATCTCCCCCATCTCACAACTGCTGTTACAAGACCGTGCTGGGGAGTGGGGCAAGGGACAGGCCCCACTGTCGGTGTGCTTGGCCC

>92382_92382_8_TMPRSS2-GRHL2_TMPRSS2_chr21_42861434_ENST00000458356_GRHL2_chr8_102564943_ENST00000395927_length(amino acids)=564AA_BP=11
MRWPLAYSGSSVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESSAIIP
VSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMYD
QTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRV
LDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGA
ERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGGSVLV
KRMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEHY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMPRSS2-GRHL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMPRSS2-GRHL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMPRSS2-GRHL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource