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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMPRSS2-HSF2BP (FusionGDB2 ID:92386)

Fusion Gene Summary for TMPRSS2-HSF2BP

check button Fusion gene summary
Fusion gene informationFusion gene name: TMPRSS2-HSF2BP
Fusion gene ID: 92386
HgeneTgene
Gene symbol

TMPRSS2

HSF2BP

Gene ID

7113

11077

Gene nametransmembrane serine protease 2heat shock transcription factor 2 binding protein
SynonymsPP9284|PRSS10MEILB2
Cytomap

21q22.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2heat shock factor 2-binding proteinmeiotic localizer of BRCA2
Modification date2020031320200313
UniProtAcc.

O75031

Ensembl transtripts involved in fusion geneENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
ENST00000291560, ENST00000542962, 
Fusion gene scores* DoF score40 X 73 X 10=2920021 X 13 X 4=1092
# samples 13022
** MAII scorelog2(130/29200*10)=-4.48938484073892
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/1092*10)=-2.31139742739519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMPRSS2 [Title/Abstract] AND HSF2BP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMPRSS2(42843733)-HSF2BP(44949842), # samples:3
Anticipated loss of major functional domain due to fusion event.TMPRSS2-HSF2BP seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-HSF2BP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

HgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843


check buttonFusion gene breakpoints across TMPRSS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HSF2BP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-P3-A6T8-01ATMPRSS2chr21

42843733

-HSF2BPchr21

44949842

-
ChimerDB4HNSCTCGA-P3-A6T8TMPRSS2chr21

42843732

-HSF2BPchr21

44949842

-
ChimerDB4HNSCTCGA-P3-A6T8TMPRSS2chr21

42843733

-HSF2BPchr21

44949842

-
ChimerDB4HNSCTCGA-P3-A6T8TMPRSS2chr21

42845252

-HSF2BPchr21

44949842

-


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Fusion Gene ORF analysis for TMPRSS2-HSF2BP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000332149ENST00000291560TMPRSS2chr21

42843733

-HSF2BPchr21

44949842

-
Frame-shiftENST00000332149ENST00000291560TMPRSS2chr21

42843732

-HSF2BPchr21

44949842

-
Frame-shiftENST00000332149ENST00000291560TMPRSS2chr21

42845252

-HSF2BPchr21

44949842

-
Frame-shiftENST00000332149ENST00000542962TMPRSS2chr21

42843733

-HSF2BPchr21

44949842

-
Frame-shiftENST00000332149ENST00000542962TMPRSS2chr21

42843732

-HSF2BPchr21

44949842

-
Frame-shiftENST00000398585ENST00000291560TMPRSS2chr21

42843733

-HSF2BPchr21

44949842

-
Frame-shiftENST00000398585ENST00000291560TMPRSS2chr21

42843732

-HSF2BPchr21

44949842

-
Frame-shiftENST00000398585ENST00000291560TMPRSS2chr21

42845252

-HSF2BPchr21

44949842

-
Frame-shiftENST00000398585ENST00000542962TMPRSS2chr21

42843733

-HSF2BPchr21

44949842

-
Frame-shiftENST00000398585ENST00000542962TMPRSS2chr21

42843732

-HSF2BPchr21

44949842

-
Frame-shiftENST00000458356ENST00000291560TMPRSS2chr21

42845252

-HSF2BPchr21

44949842

-
Frame-shiftENST00000458356ENST00000542962TMPRSS2chr21

42843733

-HSF2BPchr21

44949842

-
Frame-shiftENST00000458356ENST00000542962TMPRSS2chr21

42843732

-HSF2BPchr21

44949842

-
Frame-shiftENST00000458356ENST00000542962TMPRSS2chr21

42845252

-HSF2BPchr21

44949842

-
In-frameENST00000332149ENST00000542962TMPRSS2chr21

42845252

-HSF2BPchr21

44949842

-
In-frameENST00000398585ENST00000542962TMPRSS2chr21

42845252

-HSF2BPchr21

44949842

-
In-frameENST00000458356ENST00000291560TMPRSS2chr21

42843733

-HSF2BPchr21

44949842

-
In-frameENST00000458356ENST00000291560TMPRSS2chr21

42843732

-HSF2BPchr21

44949842

-
intron-3CDSENST00000497881ENST00000291560TMPRSS2chr21

42843733

-HSF2BPchr21

44949842

-
intron-3CDSENST00000497881ENST00000291560TMPRSS2chr21

42843732

-HSF2BPchr21

44949842

-
intron-3CDSENST00000497881ENST00000291560TMPRSS2chr21

42845252

-HSF2BPchr21

44949842

-
intron-3CDSENST00000497881ENST00000542962TMPRSS2chr21

42843733

-HSF2BPchr21

44949842

-
intron-3CDSENST00000497881ENST00000542962TMPRSS2chr21

42843732

-HSF2BPchr21

44949842

-
intron-3CDSENST00000497881ENST00000542962TMPRSS2chr21

42845252

-HSF2BPchr21

44949842

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000458356TMPRSS2chr2142843733-ENST00000291560HSF2BPchr2144949842-19351164891372427
ENST00000458356TMPRSS2chr2142843732-ENST00000291560HSF2BPchr2144949842-19351164891372427
ENST00000332149TMPRSS2chr2142845252-ENST00000542962HSF2BPchr2144949842-179510341351097320
ENST00000398585TMPRSS2chr2142845252-ENST00000542962HSF2BPchr2144949842-18321071401134364

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000458356ENST00000291560TMPRSS2chr2142843733-HSF2BPchr2144949842-0.0017485170.9982515
ENST00000458356ENST00000291560TMPRSS2chr2142843732-HSF2BPchr2144949842-0.0017485170.9982515
ENST00000332149ENST00000542962TMPRSS2chr2142845252-HSF2BPchr2144949842-0.00142040.9985796
ENST00000398585ENST00000542962TMPRSS2chr2142845252-HSF2BPchr2144949842-0.0017368020.9982632

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Fusion Genomic Features for TMPRSS2-HSF2BP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMPRSS2-HSF2BP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:42843733/chr21:44949842)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HSF2BP

O75031

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination (By similarity) (PubMed:31242413). Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (By similarity). Required for proper recombinase recruitment in female meiosis (By similarity). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). May be involved in modulating HSF2 activation in testis (PubMed:9651507). {ECO:0000250|UniProtKB:Q9D4G2, ECO:0000269|PubMed:31242413, ECO:0000269|PubMed:9651507}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000332149-1014112_149358493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000332149-1014150_242358493.0DomainSRCR
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000398585-1014112_149395530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000398585-1014150_242395530.0DomainSRCR
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000458356-1014112_149358493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000458356-1014150_242358493.0DomainSRCR
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000332149-1014112_149358493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000332149-1014150_242358493.0DomainSRCR
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000398585-1014112_149395530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000398585-1014150_242395530.0DomainSRCR
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000458356-1014112_149358493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000458356-1014150_242358493.0DomainSRCR
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000332149-914112_149299493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000332149-914150_242299493.0DomainSRCR
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000398585-914112_149336530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000398585-914150_242336530.0DomainSRCR
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000458356-914112_149299493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000458356-914150_242299493.0DomainSRCR
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000332149-10141_84358493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000398585-10141_84395530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000458356-10141_84358493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000332149-10141_84358493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000398585-10141_84395530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000458356-10141_84358493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000332149-9141_84299493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000398585-9141_84336530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000458356-9141_84299493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000332149-101485_105358493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000398585-101485_105395530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000458356-101485_105358493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000332149-101485_105358493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000398585-101485_105395530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000458356-101485_105358493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000332149-91485_105299493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000398585-91485_105336530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000458356-91485_105299493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000332149-1014256_489358493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000398585-1014256_489395530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000458356-1014256_489358493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000332149-1014256_489358493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000398585-1014256_489395530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000458356-1014256_489358493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000332149-914256_489299493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000398585-914256_489336530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000458356-914256_489299493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000332149-1014106_492358493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000398585-1014106_492395530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42843732chr21:44949842ENST00000458356-1014106_492358493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000332149-1014106_492358493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000398585-1014106_492395530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42843733chr21:44949842ENST00000458356-1014106_492358493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000332149-914106_492299493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000398585-914106_492336530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42845252chr21:44949842ENST00000458356-914106_492299493.0Topological domainExtracellular
TgeneHSF2BPchr21:42843732chr21:44949842ENST000002915607949_122265335.0Coiled coilOntology_term=ECO:0000255
TgeneHSF2BPchr21:42843733chr21:44949842ENST000002915607949_122265335.0Coiled coilOntology_term=ECO:0000255
TgeneHSF2BPchr21:42845252chr21:44949842ENST000002915607949_122265335.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for TMPRSS2-HSF2BP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92386_92386_1_TMPRSS2-HSF2BP_TMPRSS2_chr21_42843732_ENST00000458356_HSF2BP_chr21_44949842_ENST00000291560_length(transcript)=1935nt_BP=1164nt
GTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGA
TGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCA
CTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTT
CCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCC
TGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCG
ACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTTCGCC
TCTACGGACCAAACTTCATCCTTCAGGTGTACTCATCTCAGAGGAAGTCCTGGCACCCTGTGTGCCAAGACGACTGGAACGAGAACTACG
GGCGGGCGGCCTGCAGGGACATGGGCTATAAGAATAATTTTTACTCTAGCCAAGGAATAGTGGATGACAGCGGATCCACCAGCTTTATGA
AACTGAACACAAGTGCCGGCAATGTCGATATCTATAAAAAACTGTACCACAGTGATGCCTGTTCTTCAAAAGCAGTGGTTTCTTTACGCT
GTATAGCCTGCGGGGTCAACTTGAACTCAAGCCGCCAGAGCAGGATTGTGGGCGGCGAGAGCGCGCTCCCGGGGGCCTGGCCCTGGCAGG
TCAGCCTGCACGTCCAGAACGTCCACGTGTGCGGAGGCTCCATCATCACCCCCGAGTGGATCGTGACAGCCGCCCACTGCGTGGAAAAAC
CTCTTAACAATCCATGGCATTGGACGGCATTTGCGGGGATTTTGAGACAATCTTTCATGTTCTATGGAGCCGGATACCAAGTAGAAAAAG
TGATTTCTCATCCAAATTATGACTCCAAGACCAAGAACAATGACATTGCGCTGATGAAGCTGCAGAAGCCTCTGACTTTCAACGATCCAG
ATGCAGAGGTGTGCCTTCATGTACTGAGGCTTGTCCAGTCTGTGGTTCTGGAACCTGAAGTCTTCTCCAAGTCGGCCTCTGAGTTCCGGA
GCTCCCTGCCCCTGCAACGCATCCTGGCAATGTCCAAGAGCCGCAACCCCCGCCTGCAAACCGCAGCCCAGGAGCTCCTGGAAGATCTCC
GCACTCTGGAGCATAATGTGTAGGTGTGCTCGGCCACCAGGGTTTTGGTGAAAATGCCGGTGTCCCTTCTCCCCAGATCCCTCATTTGAT
ACTCCAAAACCATCACCATGTACCATGTGTTAGAGTTGGCAAAATGTGATTGACTAGAGATGGACATGAATTGATATGTATCCCACATAA
CTTTGTCTTGGAAGTGAGAGTGCTTGTAGGTGGTTGGTTAAGCTTGCCAAAGGAGAGGCCATGAAAGAACCTGTCCTTCTGGAAAAGTGG
TCCATGTCTGTGCTGGCTGGAAGAGGGCTTGCTTAGGGCAGCTTCTTGCTGCTCAGCAGACCATGACCTGTAGGTTCACCTATAAAACAG
GGAAATTGAATAACCATCTACCCCATTAGTCAGCATTTTCTTGAGATACATTTCTTTGAAAAGCAATTCATTCTCTCTCTAGTAATTGTA
ATTAATCCCCCCAAAATGCAAGTTTACTTTTATAACCTTTTGGTGAACCTGCTATTTCGGATGACATTGGGCATTTTAGTTCTATATTTT

>92386_92386_1_TMPRSS2-HSF2BP_TMPRSS2_chr21_42843732_ENST00000458356_HSF2BP_chr21_44949842_ENST00000291560_length(amino acids)=427AA_BP=344
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT
LGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQ
VSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDP

--------------------------------------------------------------
>92386_92386_2_TMPRSS2-HSF2BP_TMPRSS2_chr21_42843733_ENST00000458356_HSF2BP_chr21_44949842_ENST00000291560_length(transcript)=1935nt_BP=1164nt
GTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGA
TGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCA
CTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTT
CCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCC
TGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCG
ACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTTCGCC
TCTACGGACCAAACTTCATCCTTCAGGTGTACTCATCTCAGAGGAAGTCCTGGCACCCTGTGTGCCAAGACGACTGGAACGAGAACTACG
GGCGGGCGGCCTGCAGGGACATGGGCTATAAGAATAATTTTTACTCTAGCCAAGGAATAGTGGATGACAGCGGATCCACCAGCTTTATGA
AACTGAACACAAGTGCCGGCAATGTCGATATCTATAAAAAACTGTACCACAGTGATGCCTGTTCTTCAAAAGCAGTGGTTTCTTTACGCT
GTATAGCCTGCGGGGTCAACTTGAACTCAAGCCGCCAGAGCAGGATTGTGGGCGGCGAGAGCGCGCTCCCGGGGGCCTGGCCCTGGCAGG
TCAGCCTGCACGTCCAGAACGTCCACGTGTGCGGAGGCTCCATCATCACCCCCGAGTGGATCGTGACAGCCGCCCACTGCGTGGAAAAAC
CTCTTAACAATCCATGGCATTGGACGGCATTTGCGGGGATTTTGAGACAATCTTTCATGTTCTATGGAGCCGGATACCAAGTAGAAAAAG
TGATTTCTCATCCAAATTATGACTCCAAGACCAAGAACAATGACATTGCGCTGATGAAGCTGCAGAAGCCTCTGACTTTCAACGATCCAG
ATGCAGAGGTGTGCCTTCATGTACTGAGGCTTGTCCAGTCTGTGGTTCTGGAACCTGAAGTCTTCTCCAAGTCGGCCTCTGAGTTCCGGA
GCTCCCTGCCCCTGCAACGCATCCTGGCAATGTCCAAGAGCCGCAACCCCCGCCTGCAAACCGCAGCCCAGGAGCTCCTGGAAGATCTCC
GCACTCTGGAGCATAATGTGTAGGTGTGCTCGGCCACCAGGGTTTTGGTGAAAATGCCGGTGTCCCTTCTCCCCAGATCCCTCATTTGAT
ACTCCAAAACCATCACCATGTACCATGTGTTAGAGTTGGCAAAATGTGATTGACTAGAGATGGACATGAATTGATATGTATCCCACATAA
CTTTGTCTTGGAAGTGAGAGTGCTTGTAGGTGGTTGGTTAAGCTTGCCAAAGGAGAGGCCATGAAAGAACCTGTCCTTCTGGAAAAGTGG
TCCATGTCTGTGCTGGCTGGAAGAGGGCTTGCTTAGGGCAGCTTCTTGCTGCTCAGCAGACCATGACCTGTAGGTTCACCTATAAAACAG
GGAAATTGAATAACCATCTACCCCATTAGTCAGCATTTTCTTGAGATACATTTCTTTGAAAAGCAATTCATTCTCTCTCTAGTAATTGTA
ATTAATCCCCCCAAAATGCAAGTTTACTTTTATAACCTTTTGGTGAACCTGCTATTTCGGATGACATTGGGCATTTTAGTTCTATATTTT

>92386_92386_2_TMPRSS2-HSF2BP_TMPRSS2_chr21_42843733_ENST00000458356_HSF2BP_chr21_44949842_ENST00000291560_length(amino acids)=427AA_BP=344
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT
LGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQ
VSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDP

--------------------------------------------------------------
>92386_92386_3_TMPRSS2-HSF2BP_TMPRSS2_chr21_42845252_ENST00000332149_HSF2BP_chr21_44949842_ENST00000542962_length(transcript)=1795nt_BP=1034nt
CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA
CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTAT
GAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTAC
CCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACA
GTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCCTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTC
TGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCGACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGC
GTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTTCGCCTCTACGGACCAAACTTCATCCTTCAGGTGTACTCATCTCAGAGG
AAGTCCTGGCACCCTGTGTGCCAAGACGACTGGAACGAGAACTACGGGCGGGCGGCCTGCAGGGACATGGGCTATAAGAATAATTTTTAC
TCTAGCCAAGGAATAGTGGATGACAGCGGATCCACCAGCTTTATGAAACTGAACACAAGTGCCGGCAATGTCGATATCTATAAAAAACTG
TACCACAGTGATGCCTGTTCTTCAAAAGCAGTGGTTTCTTTACGCTGTATAGCCTGCGGGGTCAACTTGAACTCAAGCCGCCAGAGCAGG
ATTGTGGGCGGCGAGAGCGCGCTCCCGGGGGCCTGGCCCTGGCAGGTCAGCCTGCACGTCCAGAACGTCCACGTGTGCGGAGGCTCCATC
ATCACCCCCGAGTGGATCGTGACAGCCGCCCACTGCGTGGAAAAATCCAGATGCAGAGGTGTGCCTTCATGTACTGAGGCTTGTCCAGTC
TGTGGTTCTGGAACCTGAAGTCTTCTCCAAGTCGGCCTCTGAGTTCCGGAGCTCCCTGCCCCTGCAACGCATCCTGGCAATGTCCAAGAG
CCGCAACCCCCGCCTGCAAACCGCAGCCCAGGAGCTCCTGGAAGATCTCCGCACTCTGGAGCATAATGTGTAGGTGTGCTCGGCCACCAG
GGTTTTGGTGAAAATGCCGGTGTCCCTTCTCCCCAGATCCCTCATTTGATACTCCAAAACCATCACCATGTACCATGTGTTAGAGTTGGC
AAAATGTGATTGACTAGAGATGGACATGAATTGATATGTATCCCACATAACTTTGTCTTGGAAGTGAGAGTGCTTGTAGGTGGTTGGTTA
AGCTTGCCAAAGGAGAGGCCATGAAAGAACCTGTCCTTCTGGAAAAGTGGTCCATGTCTGTGCTGGCTGGAAGAGGGCTTGCTTAGGGCA
GCTTCTTGCTGCTCAGCAGACCATGACCTGTAGGTTCACCTATAAAACAGGGAAATTGAATAACCATCTACCCCATTAGTCAGCATTTTC
TTGAGATACATTTCTTTGAAAAGCAATTCATTCTCTCTCTAGTAATTGTAATTAATCCCCCCAAAATGCAAGTTTACTTTTATAACCTTT

>92386_92386_3_TMPRSS2-HSF2BP_TMPRSS2_chr21_42845252_ENST00000332149_HSF2BP_chr21_44949842_ENST00000542962_length(amino acids)=320AA_BP=300
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT
LGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQ

--------------------------------------------------------------
>92386_92386_4_TMPRSS2-HSF2BP_TMPRSS2_chr21_42845252_ENST00000398585_HSF2BP_chr21_44949842_ENST00000542962_length(transcript)=1832nt_BP=1071nt
ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG
CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT
GAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGT
CCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCC
CGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCCTGGGGAC
CTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCGACTCCTC
AGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTTCGCCTCTACGG
ACCAAACTTCATCCTTCAGGTGTACTCATCTCAGAGGAAGTCCTGGCACCCTGTGTGCCAAGACGACTGGAACGAGAACTACGGGCGGGC
GGCCTGCAGGGACATGGGCTATAAGAATAATTTTTACTCTAGCCAAGGAATAGTGGATGACAGCGGATCCACCAGCTTTATGAAACTGAA
CACAAGTGCCGGCAATGTCGATATCTATAAAAAACTGTACCACAGTGATGCCTGTTCTTCAAAAGCAGTGGTTTCTTTACGCTGTATAGC
CTGCGGGGTCAACTTGAACTCAAGCCGCCAGAGCAGGATTGTGGGCGGCGAGAGCGCGCTCCCGGGGGCCTGGCCCTGGCAGGTCAGCCT
GCACGTCCAGAACGTCCACGTGTGCGGAGGCTCCATCATCACCCCCGAGTGGATCGTGACAGCCGCCCACTGCGTGGAAAAATCCAGATG
CAGAGGTGTGCCTTCATGTACTGAGGCTTGTCCAGTCTGTGGTTCTGGAACCTGAAGTCTTCTCCAAGTCGGCCTCTGAGTTCCGGAGCT
CCCTGCCCCTGCAACGCATCCTGGCAATGTCCAAGAGCCGCAACCCCCGCCTGCAAACCGCAGCCCAGGAGCTCCTGGAAGATCTCCGCA
CTCTGGAGCATAATGTGTAGGTGTGCTCGGCCACCAGGGTTTTGGTGAAAATGCCGGTGTCCCTTCTCCCCAGATCCCTCATTTGATACT
CCAAAACCATCACCATGTACCATGTGTTAGAGTTGGCAAAATGTGATTGACTAGAGATGGACATGAATTGATATGTATCCCACATAACTT
TGTCTTGGAAGTGAGAGTGCTTGTAGGTGGTTGGTTAAGCTTGCCAAAGGAGAGGCCATGAAAGAACCTGTCCTTCTGGAAAAGTGGTCC
ATGTCTGTGCTGGCTGGAAGAGGGCTTGCTTAGGGCAGCTTCTTGCTGCTCAGCAGACCATGACCTGTAGGTTCACCTATAAAACAGGGA
AATTGAATAACCATCTACCCCATTAGTCAGCATTTTCTTGAGATACATTTCTTTGAAAAGCAATTCATTCTCTCTCTAGTAATTGTAATT
AATCCCCCCAAAATGCAAGTTTACTTTTATAACCTTTTGGTGAACCTGCTATTTCGGATGACATTGGGCATTTTAGTTCTATATTTTTTG

>92386_92386_4_TMPRSS2-HSF2BP_TMPRSS2_chr21_42845252_ENST00000398585_HSF2BP_chr21_44949842_ENST00000542962_length(amino acids)=364AA_BP=344
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGV
SHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLY
HSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKSRCRGVPSCTEACPVC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMPRSS2-HSF2BP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneHSF2BPchr21:42843732chr21:44949842ENST000002915607983_334265.3333333333333335.0BRCA2
TgeneHSF2BPchr21:42843733chr21:44949842ENST000002915607983_334265.3333333333333335.0BRCA2
TgeneHSF2BPchr21:42845252chr21:44949842ENST000002915607983_334265.3333333333333335.0BRCA2
TgeneHSF2BPchr21:42843732chr21:44949842ENST000002915607914_51265.3333333333333335.0BRME1
TgeneHSF2BPchr21:42843733chr21:44949842ENST000002915607914_51265.3333333333333335.0BRME1
TgeneHSF2BPchr21:42845252chr21:44949842ENST000002915607914_51265.3333333333333335.0BRME1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMPRSS2-HSF2BP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMPRSS2-HSF2BP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource