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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMPRSS2-MORC3 (FusionGDB2 ID:92395)

Fusion Gene Summary for TMPRSS2-MORC3

Fusion gene summary

Fusion gene information	Fusion gene name: TMPRSS2-MORC3
	Fusion gene ID: 92395
		Hgene	Tgene
	Gene symbol	TMPRSS2	MORC3
	Gene ID	7113	23515
	Gene name	transmembrane serine protease 2	MORC family CW-type zinc finger 3
	Synonyms	PP9284\|PRSS10	NXP2\|ZCW5\|ZCWCC3
	Cytomap	21q22.3	21q22.12
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2	MORC family CW-type zinc finger protein 3nuclear matrix protein 2nuclear matrix protein NXP2zinc finger CW-type coiled-coil domain protein 3zinc finger, CW type with coiled-coil domain 3
	Modification date	20200313	20200320
	UniProtAcc	.	Q14149
	Ensembl transtripts involved in fusion gene	ENST00000332149, ENST00000398585, ENST00000458356, ENST00000497881,	ENST00000487909, ENST00000400485,
Fusion gene scores	* DoF score	40 X 73 X 10=29200	8 X 11 X 4=352
	# samples	130	11
	** MAII score	log2(130/29200*10)=-4.48938484073892 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/352*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TMPRSS2 [Title/Abstract] AND MORC3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMPRSS2(42870046)-MORC3(37705944), # samples:2 TMPRSS2(42880007)-MORC3(37705943), # samples:2
Anticipated loss of major functional domain due to fusion event.	TMPRSS2-MORC3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. TMPRSS2-MORC3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. TMPRSS2-MORC3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TMPRSS2	GO:0006508	proteolysis	21068237\|24227843
Hgene	TMPRSS2	GO:0046598	positive regulation of viral entry into host cell	21068237\|24227843
Tgene	MORC3	GO:0006468	protein phosphorylation	17332504
Tgene	MORC3	GO:0007569	cell aging	17332504
Tgene	MORC3	GO:0018105	peptidyl-serine phosphorylation	17332504
Tgene	MORC3	GO:0048147	negative regulation of fibroblast proliferation	17332504
Tgene	MORC3	GO:0050821	protein stabilization	17332504
Tgene	MORC3	GO:0051457	maintenance of protein location in nucleus	17332504

Fusion gene breakpoints across TMPRSS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MORC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-CH-5762-01A	TMPRSS2	chr21	42870046	-	MORC3	chr21	37705944	+
ChimerDB4	PRAD	TCGA-CH-5762	TMPRSS2	chr21	42880007	-	MORC3	chr21	37705943	+

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Fusion Gene ORF analysis for TMPRSS2-MORC3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000332149	ENST00000487909	TMPRSS2	chr21	42870046	-	MORC3	chr21	37705944	+
5CDS-intron	ENST00000398585	ENST00000487909	TMPRSS2	chr21	42870046	-	MORC3	chr21	37705944	+
5CDS-intron	ENST00000458356	ENST00000487909	TMPRSS2	chr21	42870046	-	MORC3	chr21	37705944	+
5UTR-3CDS	ENST00000332149	ENST00000400485	TMPRSS2	chr21	42880007	-	MORC3	chr21	37705943	+
5UTR-3CDS	ENST00000497881	ENST00000400485	TMPRSS2	chr21	42870046	-	MORC3	chr21	37705944	+
5UTR-3CDS	ENST00000497881	ENST00000400485	TMPRSS2	chr21	42880007	-	MORC3	chr21	37705943	+
5UTR-intron	ENST00000332149	ENST00000487909	TMPRSS2	chr21	42880007	-	MORC3	chr21	37705943	+
5UTR-intron	ENST00000497881	ENST00000487909	TMPRSS2	chr21	42870046	-	MORC3	chr21	37705944	+
5UTR-intron	ENST00000497881	ENST00000487909	TMPRSS2	chr21	42880007	-	MORC3	chr21	37705943	+
Frame-shift	ENST00000458356	ENST00000400485	TMPRSS2	chr21	42870046	-	MORC3	chr21	37705944	+
In-frame	ENST00000332149	ENST00000400485	TMPRSS2	chr21	42870046	-	MORC3	chr21	37705944	+
In-frame	ENST00000398585	ENST00000400485	TMPRSS2	chr21	42870046	-	MORC3	chr21	37705944	+
intron-3CDS	ENST00000398585	ENST00000400485	TMPRSS2	chr21	42880007	-	MORC3	chr21	37705943	+
intron-3CDS	ENST00000458356	ENST00000400485	TMPRSS2	chr21	42880007	-	MORC3	chr21	37705943	+
intron-intron	ENST00000398585	ENST00000487909	TMPRSS2	chr21	42880007	-	MORC3	chr21	37705943	+
intron-intron	ENST00000458356	ENST00000487909	TMPRSS2	chr21	42880007	-	MORC3	chr21	37705943	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000332149

TMPRSS2

chr21

42870046

ENST00000400485

MORC3

chr21

37705944

4281

150

135

2930

931

ENST00000398585

TMPRSS2

chr21

42870046

ENST00000400485

MORC3

chr21

37705944

4318

187

2967

975

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000332149	ENST00000400485	TMPRSS2	chr21	42870046	-	MORC3	chr21	37705944	+	0.000197243	0.99980277
ENST00000398585	ENST00000400485	TMPRSS2	chr21	42870046	-	MORC3	chr21	37705944	+	0.000146029	0.99985397

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Fusion Genomic Features for TMPRSS2-MORC3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TMPRSS2	chr21	42880007	-	MORC3	chr21	37705943	+	0.000104626	0.99989533
TMPRSS2	chr21	42870045	-	MORC3	chr21	37705943	+	3.15E-06	0.9999969
TMPRSS2	chr21	42880007	-	MORC3	chr21	37705943	+	0.000104626	0.99989533
TMPRSS2	chr21	42870045	-	MORC3	chr21	37705943	+	3.15E-06	0.9999969

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMPRSS2-MORC3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:42870046/chr21:37705944)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MORC3 Q14149
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269\|PubMed:11927593, ECO:0000269\|PubMed:17332504, ECO:0000269\|PubMed:20501696, ECO:0000269\|PubMed:26202233, ECO:0000269\|PubMed:26933034}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MORC3

chr21:42870046

chr21:37705944

ENST00000400485

686_877

940.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC3

chr21:42870046

chr21:37705944

ENST00000400485

326_353

940.0

Region

Nuclear matrix binding

Tgene

MORC3

chr21:42870046

chr21:37705944

ENST00000400485

500_591

940.0

Region

RNA binding

Tgene

MORC3

chr21:42870046

chr21:37705944

ENST00000400485

404_454

940.0

Zinc finger

CW-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000332149

112_149

493.0

Domain

LDL-receptor class A

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000332149

150_242

493.0

Domain

SRCR

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000332149

256_489

493.0

Domain

Peptidase S1

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000398585

112_149

530.0

Domain

LDL-receptor class A

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000398585

150_242

530.0

Domain

SRCR

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000398585

256_489

530.0

Domain

Peptidase S1

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000458356

112_149

493.0

Domain

LDL-receptor class A

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000458356

150_242

493.0

Domain

SRCR

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000458356

256_489

493.0

Domain

Peptidase S1

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000332149

106_492

493.0

Topological domain

Extracellular

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000332149

1_84

493.0

Topological domain

Cytoplasmic

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000398585

106_492

530.0

Topological domain

Extracellular

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000398585

1_84

530.0

Topological domain

Cytoplasmic

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000458356

106_492

493.0

Topological domain

Extracellular

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000458356

1_84

493.0

Topological domain

Cytoplasmic

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000332149

85_105

493.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000398585

85_105

530.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

TMPRSS2

chr21:42870046

chr21:37705944

ENST00000458356

85_105

493.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Gene Sequence for TMPRSS2-MORC3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>92395_92395_1_TMPRSS2-MORC3_TMPRSS2_chr21_42870046_ENST00000332149_MORC3_chr21_37705944_ENST00000400485_length(transcript)=4281nt_BP=150nt
CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA
CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCACTTTGCCCGAAGTTTTTACATACAAATTCT
ACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGAATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGAC
AAAACAGTGATAAATGACCATATATGCTTGACATTCACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTT
GGCTTCAGTGACAAAGTCACCATGAATGGTCATGTCCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAA
GACGCAATCGTTTTTACCAAAAATGGAGAAAGCATGAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTT
GTTGTTCCAATAGTGGCATTCAACAAGCACCGACAGATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCT
CTGTTTTCCACGGAACAGAAGTTACTGGCAGAACTTGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGC
TACAAAAATGCAACAGAGTTCGATTTTGAAAAGGATAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGG
TACAAGAAGCAGGAAAGGATGGACCAGATTGCCCCTGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGA
ATGCAGATCATCCTACGTGGACAGAAAGTGAAGACACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAA
TTTTTATCTAAAACAGTGAGAATTACCTTTGGATTCAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTC
ATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAGGGCAAACAACATGGGTGTTGGAGTGGTTGGAATTATAGAGTGTAATTTCCTTAAG
CCAACTCATAATAAACAAGATTTCGACTATACTAATGAGTACAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAAT
GAAATGAAAGTGAAGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGT
GATGCCTGTCTAAAGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTC
AGAAATTGTGAGGTTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAA
TTCAGGATCAGACAACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCT
CCTAAGGAAAGTGTTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAG
TCTGAACCTGAGAGCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTT
GAAAATTCAGTTTATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGAT
ATTGACATGAAATCAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGT
TCAACAAGCACCTCATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAA
ACTGTTGAAGACGAGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAA
ACCACCGATAAATCTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTAT
AAAAGACAGTGTCATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACT
TGCCATCAGTCCACTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTAT
CAGCAAGCTTTGGAAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAAT
GAGAGTAAAAGTGAAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTAT
AAAAGTGAGGTTGAATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCT
ACAAATCAACAGACGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGA
TCTCTTCGAGTTAACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGAT
GAGATTTTAGGACAAGTTGTTGAACAAATGAGTGAAATCAGTAGTACTTAAAGTATATGTTATGTAAGATAAAATATTTGCTCAATTCTT
TTGGTTGTACAGCTTTCAAAATATAATTAATTTTGTTTTATAGATATGATAGGCAACAGACTGAAAACCATAATCTTTACTGTATTCTAT
GCATTCAAATGTGGTCACAAATATTGTGGACACATTATCTTATGTTTTGAAATACCTGTGAATTGTTGGCATTGAGCAGCTGAAGCTAAC
TCATGACTCTGTTTTGAATGTAAATATTTGTAATTAAGCCTGCACATATTTTTTTATTGCCCTAGAGTACTCAAGTGTTTTTCACCAAGA
GCTTTTCAGGTTGCCCCTAAGCTTTGTGCAATTTTTTCTGGTTCCCCAAAGTGTATTTTTCTCTAAGTCGAGGGCTATGCCATAATACAA
ATGGAAATGTTACCTTTGATTTTCTTATAAAGGAGTTTAAATAGGATTTTTAAATAATGTAGTAACACTCCTGATACAACTCTGGTTATA
AGTGAATTGAGCATTAATGTTTCTTTTGTATAAATTCCTGTCCTGAAATATTTTATTCATGAAAATAAGGTAAGCAAAAACCAACTCCAT
TTTGCCAGGATTTTGTTGTGCTGAGATTGCCAATCACGGTTAAACACAAAGTGTTTTTATAGAATGAAGAAACAGTCTTTAACAGAAAAA
AGGTATTGAAATATTAAATGGCCACCAAGTTTACTTTGAAGCCCATTTTTGGCTGTTTAGTCAGCATGAAGTGGGCATGATAATTTTTTA
ATATTTCTTTTTGTGAAATTTCCTGTACAGCCTTTTGTAGGATTACTACAGGTTAATGTGAGTTGAGGAAGACAGTCTTTCTCAAACAAT
ACTACATACCTTTTATTATATTACAAACCTAAGTGTTTTATATCCTAGAGTCAAGGAACAAATTTCCTTAGGATTATAGTATTACATGCC
ATAAAATACTATGCTTTATTGGTCCCATGTTTTGTGCAATTTTAAAGAGATGGCTTTCTATTAAGTATAAACTATGTATATATAAGAACC
ATATTTTCCACAACTAAAATGTGCATTATTTTTTCCAAAGTTTTATCATTGCTATTTATTTTTACCTTTGTTTTTGAACATTCAATCCGT
TCATTTTGTATGTATGCTTAATACGTGTCGGTCATATACAGTATTGAATTTTTACTGTATAGTAATTCTGGAAAGAGCAAATAAATGAAG
ATTGTTTTTATTTGCCTGATAAAGTAATTGAAAGTGTATTTTTGGTATGAAGCTGGTTTTCTGTCACAATTGTAATTTCCCAAATTTTAA

>92395_92395_1_TMPRSS2-MORC3_TMPRSS2_chr21_42870046_ENST00000332149_MORC3_chr21_37705944_ENST00000400485_length(amino acids)=931AA_BP=5
MALNSLCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVG
LYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQKLLAELDAI
IGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLV
SKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYR
LTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLV
HPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTR
SSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTA
ATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQ
QRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDD
VFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVP

--------------------------------------------------------------
>92395_92395_2_TMPRSS2-MORC3_TMPRSS2_chr21_42870046_ENST00000398585_MORC3_chr21_37705944_ENST00000400485_length(transcript)=4318nt_BP=187nt
ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG
CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT
GAACTCACTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGAATTAATAGATAATGCTTA
TGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATTCACCGACAATGGGAATGG
TATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGTCCCAGTTGGATTATATGG
GAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCATGAGCGTGGGCCTTTTGTC
TCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACAGATGATTAATTTAGCAGA
ATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACTTGATGCTATTATAGGCAA
GAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGATAAATATGATATCAGAAT
TCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCCTGAGAGTGACTATTCCCT
GAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGACACAGCTGGTTTCGAAGAG
TCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATTCAACTGCAGAAATAAAGA
TCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAGGGCAAACAACATGGGTGT
TGGAGTGGTTGGAATTATAGAGTGTAATTTCCTTAAGCCAACTCATAATAAACAAGATTTCGACTATACTAATGAGTACAGACTTACAAT
AACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTGAAGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGA
TATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTAAAGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGA
AAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAGGTTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCAC
TTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGACAACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTT
TCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGTGTTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGC
GACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAGAGCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAAT
TTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTTTATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGA
AGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAATCAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGA
GTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACCTCATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCA
GACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGACGAGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTG
TGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAATCTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAA
CCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGTCATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGAT
ACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCCACTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGG
CAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTGGAAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCA
ACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGTGAAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAG
ACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTTGAATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTG
TGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAGACGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTC
TGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTTAACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGA
TCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGACAAGTTGTTGAACAAATGAGTGAAATCAGTAGTACTTAAAG
TATATGTTATGTAAGATAAAATATTTGCTCAATTCTTTTGGTTGTACAGCTTTCAAAATATAATTAATTTTGTTTTATAGATATGATAGG
CAACAGACTGAAAACCATAATCTTTACTGTATTCTATGCATTCAAATGTGGTCACAAATATTGTGGACACATTATCTTATGTTTTGAAAT
ACCTGTGAATTGTTGGCATTGAGCAGCTGAAGCTAACTCATGACTCTGTTTTGAATGTAAATATTTGTAATTAAGCCTGCACATATTTTT
TTATTGCCCTAGAGTACTCAAGTGTTTTTCACCAAGAGCTTTTCAGGTTGCCCCTAAGCTTTGTGCAATTTTTTCTGGTTCCCCAAAGTG
TATTTTTCTCTAAGTCGAGGGCTATGCCATAATACAAATGGAAATGTTACCTTTGATTTTCTTATAAAGGAGTTTAAATAGGATTTTTAA
ATAATGTAGTAACACTCCTGATACAACTCTGGTTATAAGTGAATTGAGCATTAATGTTTCTTTTGTATAAATTCCTGTCCTGAAATATTT
TATTCATGAAAATAAGGTAAGCAAAAACCAACTCCATTTTGCCAGGATTTTGTTGTGCTGAGATTGCCAATCACGGTTAAACACAAAGTG
TTTTTATAGAATGAAGAAACAGTCTTTAACAGAAAAAAGGTATTGAAATATTAAATGGCCACCAAGTTTACTTTGAAGCCCATTTTTGGC
TGTTTAGTCAGCATGAAGTGGGCATGATAATTTTTTAATATTTCTTTTTGTGAAATTTCCTGTACAGCCTTTTGTAGGATTACTACAGGT
TAATGTGAGTTGAGGAAGACAGTCTTTCTCAAACAATACTACATACCTTTTATTATATTACAAACCTAAGTGTTTTATATCCTAGAGTCA
AGGAACAAATTTCCTTAGGATTATAGTATTACATGCCATAAAATACTATGCTTTATTGGTCCCATGTTTTGTGCAATTTTAAAGAGATGG
CTTTCTATTAAGTATAAACTATGTATATATAAGAACCATATTTTCCACAACTAAAATGTGCATTATTTTTTCCAAAGTTTTATCATTGCT
ATTTATTTTTACCTTTGTTTTTGAACATTCAATCCGTTCATTTTGTATGTATGCTTAATACGTGTCGGTCATATACAGTATTGAATTTTT
ACTGTATAGTAATTCTGGAAAGAGCAAATAAATGAAGATTGTTTTTATTTGCCTGATAAAGTAATTGAAAGTGTATTTTTGGTATGAAGC

>92395_92395_2_TMPRSS2-MORC3_TMPRSS2_chr21_42870046_ENST00000398585_MORC3_chr21_37705944_ENST00000400485_length(amino acids)=975AA_BP=49
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSLCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDK
TVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVV
VPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGY
KKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLI
KAYEKVGCQLRANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCD
ACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSP
KESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDI
DMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQET
TDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQ
QALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKST

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Top

Fusion Gene PPI Analysis for TMPRSS2-MORC3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TMPRSS2-MORC3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TMPRSS2-MORC3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source