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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMPRSS2-PDE9A (FusionGDB2 ID:92398)

Fusion Gene Summary for TMPRSS2-PDE9A

check button Fusion gene summary
Fusion gene informationFusion gene name: TMPRSS2-PDE9A
Fusion gene ID: 92398
HgeneTgene
Gene symbol

TMPRSS2

PDE9A

Gene ID

7113

5152

Gene nametransmembrane serine protease 2phosphodiesterase 9A
SynonymsPP9284|PRSS10HSPDE9A2
Cytomap

21q22.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9ACGMP-specific 3',5'-cyclic phosphodiesterase type 9phosphodiesterase PDE9A21
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
ENST00000291539, ENST00000328862, 
ENST00000335440, ENST00000349112, 
ENST00000380328, ENST00000398224, 
ENST00000398225, ENST00000398227, 
ENST00000398229, ENST00000398232, 
ENST00000398234, ENST00000398236, 
ENST00000470987, ENST00000335512, 
ENST00000539837, 
Fusion gene scores* DoF score40 X 73 X 10=2920013 X 13 X 6=1014
# samples 13014
** MAII scorelog2(130/29200*10)=-4.48938484073892
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1014*10)=-2.85655892005837
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMPRSS2 [Title/Abstract] AND PDE9A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDE9A(44153536)-TMPRSS2(42870116), # samples:4
TMPRSS2(42866283)-PDE9A(44163886), # samples:3
Anticipated loss of major functional domain due to fusion event.TMPRSS2-PDE9A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-PDE9A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TMPRSS2-PDE9A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TMPRSS2-PDE9A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

HgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843

TgenePDE9A

GO:0046068

cGMP metabolic process

9624146

TgenePDE9A

GO:0046069

cGMP catabolic process

25799991


check buttonFusion gene breakpoints across TMPRSS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDE9A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-ZG-A9L2-01ATMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
ChimerDB4PRADTCGA-ZG-A9L2TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+


Top

Fusion Gene ORF analysis for TMPRSS2-PDE9A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000332149ENST00000291539TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000332149ENST00000328862TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000332149ENST00000335440TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000332149ENST00000349112TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000332149ENST00000380328TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000332149ENST00000398224TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000332149ENST00000398225TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000332149ENST00000398227TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000332149ENST00000398229TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000332149ENST00000398232TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000332149ENST00000398234TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000332149ENST00000398236TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000332149ENST00000470987TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000398585ENST00000291539TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000398585ENST00000328862TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000398585ENST00000335440TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000398585ENST00000349112TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000398585ENST00000380328TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000398585ENST00000398224TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000398585ENST00000398225TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000398585ENST00000398227TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000398585ENST00000398229TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000398585ENST00000398232TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000398585ENST00000398234TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000398585ENST00000398236TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000398585ENST00000470987TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000458356ENST00000291539TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000458356ENST00000328862TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000458356ENST00000335440TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000458356ENST00000349112TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000458356ENST00000380328TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000458356ENST00000398224TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000458356ENST00000398225TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000458356ENST00000398227TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000458356ENST00000398229TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000458356ENST00000398232TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000458356ENST00000398234TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000458356ENST00000398236TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
5CDS-3UTRENST00000458356ENST00000470987TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
Frame-shiftENST00000458356ENST00000335512TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
Frame-shiftENST00000458356ENST00000539837TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
In-frameENST00000332149ENST00000335512TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
In-frameENST00000332149ENST00000539837TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
In-frameENST00000398585ENST00000335512TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
In-frameENST00000398585ENST00000539837TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3CDSENST00000497881ENST00000335512TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3CDSENST00000497881ENST00000539837TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3UTRENST00000497881ENST00000291539TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3UTRENST00000497881ENST00000328862TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3UTRENST00000497881ENST00000335440TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3UTRENST00000497881ENST00000349112TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3UTRENST00000497881ENST00000380328TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3UTRENST00000497881ENST00000398224TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3UTRENST00000497881ENST00000398225TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3UTRENST00000497881ENST00000398227TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3UTRENST00000497881ENST00000398229TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3UTRENST00000497881ENST00000398232TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3UTRENST00000497881ENST00000398234TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3UTRENST00000497881ENST00000398236TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+
intron-3UTRENST00000497881ENST00000470987TMPRSS2chr21

42866283

-PDE9Achr21

44163886

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000332149TMPRSS2chr2142866283-ENST00000335512PDE9Achr2144163886+18033731351586483
ENST00000332149TMPRSS2chr2142866283-ENST00000539837PDE9Achr2144163886+18003731351586483
ENST00000398585TMPRSS2chr2142866283-ENST00000335512PDE9Achr2144163886+1840410401623527
ENST00000398585TMPRSS2chr2142866283-ENST00000539837PDE9Achr2144163886+1837410401623527

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000332149ENST00000335512TMPRSS2chr2142866283-PDE9Achr2144163886+0.0031817590.9968182
ENST00000332149ENST00000539837TMPRSS2chr2142866283-PDE9Achr2144163886+0.0032105410.9967894
ENST00000398585ENST00000335512TMPRSS2chr2142866283-PDE9Achr2144163886+0.0020646340.9979354
ENST00000398585ENST00000539837TMPRSS2chr2142866283-PDE9Achr2144163886+0.0020806170.9979194

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Fusion Genomic Features for TMPRSS2-PDE9A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMPRSS2chr2142866282-PDE9Achr2144163885+1.18E-060.9999988
TMPRSS2chr2142866282-PDE9Achr2144163885+1.18E-060.9999988
TMPRSS2chr2142866282-PDE9Achr2144163885+1.18E-060.9999988
TMPRSS2chr2142866282-PDE9Achr2144163885+1.18E-060.9999988

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for TMPRSS2-PDE9A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:44153536/chr21:42870116)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000398585-3141_84116530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000398585-31485_105116530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgenePDE9Achr21:42866283chr21:44163886ENST00000291539620236_557189594.0DomainPDEase
TgenePDE9Achr21:42866283chr21:44163886ENST00000328862519236_557163568.0DomainPDEase
TgenePDE9Achr21:42866283chr21:44163886ENST00000335440317236_55787492.0DomainPDEase
TgenePDE9Achr21:42866283chr21:44163886ENST00000335512519236_557129534.0DomainPDEase
TgenePDE9Achr21:42866283chr21:44163886ENST00000349112216236_55761466.0DomainPDEase
TgenePDE9Achr21:42866283chr21:44163886ENST00000380328519236_557136541.0DomainPDEase
TgenePDE9Achr21:42866283chr21:44163886ENST00000398224317236_55762467.0DomainPDEase
TgenePDE9Achr21:42866283chr21:44163886ENST00000398225519236_557148553.0DomainPDEase
TgenePDE9Achr21:42866283chr21:44163886ENST00000398227115236_55729434.0DomainPDEase
TgenePDE9Achr21:42866283chr21:44163886ENST00000398229216236_55755460.0DomainPDEase
TgenePDE9Achr21:42866283chr21:44163886ENST00000398232418236_557122527.0DomainPDEase
TgenePDE9Achr21:42866283chr21:44163886ENST00000398234418236_55788493.0DomainPDEase
TgenePDE9Achr21:42866283chr21:44163886ENST00000398236418236_557103508.0DomainPDEase
TgenePDE9Achr21:42866283chr21:44163886ENST00000291539620312_316189594.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000291539620512_513189594.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000328862519312_316163568.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000328862519512_513163568.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000335440317312_31687492.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000335440317512_51387492.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000335512519312_316129534.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000335512519512_513129534.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000349112216312_31661466.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000349112216512_51361466.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000380328519312_316136541.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000380328519512_513136541.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000398224317312_31662467.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000398224317512_51362467.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000398225519312_316148553.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000398225519512_513148553.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000398227115312_31629434.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000398227115512_51329434.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000398229216312_31655460.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000398229216512_51355460.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000398232418312_316122527.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000398232418512_513122527.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000398234418312_31688493.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000398234418512_51388493.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000398236418312_316103508.0Nucleotide binding3'%2C5'-cGMP
TgenePDE9Achr21:42866283chr21:44163886ENST00000398236418512_513103508.0Nucleotide binding3'%2C5'-cGMP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000332149-314112_14979493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000332149-314150_24279493.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000332149-314256_48979493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000398585-314112_149116530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000398585-314150_242116530.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000398585-314256_489116530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000458356-314112_14979493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000458356-314150_24279493.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000458356-314256_48979493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000332149-314106_49279493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000332149-3141_8479493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000398585-314106_492116530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000458356-314106_49279493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000458356-3141_8479493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000332149-31485_10579493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866283chr21:44163886ENST00000458356-31485_10579493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for TMPRSS2-PDE9A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92398_92398_1_TMPRSS2-PDE9A_TMPRSS2_chr21_42866283_ENST00000332149_PDE9A_chr21_44163886_ENST00000335512_length(transcript)=1803nt_BP=373nt
CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA
CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTAT
GAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTAC
CCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACA
GTGTGCACCTCAATGGAAGGACTAAAAGTGGTGGAGATTGAGAAATGCAAGAGTGACATTAAGAAGATGAGGGAGGAGCTGGCGGCCAGA
AGCAGCAGGACCAACTGCCCCTGTAAGTACAGTTTTTTGGATAACCACAAGAAGTTGACTCCTCGACGCGATGTTCCCACTTACCCCAAG
TACCTGCTCTCTCCAGAGACCATCGAGGCCCTGCGGAAGCCGACCTTTGACGTCTGGCTTTGGGAGCCCAATGAGATGCTGAGCTGCCTG
GAGCACATGTACCACGACCTCGGGCTGGTCAGGGACTTCAGCATCAACCCTGTCACCCTCAGGAGGTGGCTGTTCTGCGTCCACGACAAC
TACAGAAACAACCCCTTCCACAACTTCCGGCACTGCTTCTGCGTGGCCCAGATGATGTACAGCATGGTCTGGCTCTGCAGTCTCCAGGAG
AAGTTCTCACAAACGGATATCCTGATCCTAATGACAGCGGCCATCTGCCACGATCTGGACCATCCCGGCTACAACAACACGTACCAGATC
AATGCCCGCACAGAGCTGGCGGTCCGCTACAATGACATCTCACCGCTGGAGAACCACCACTGCGCCGTGGCCTTCCAGATCCTCGCCGAG
CCTGAGTGCAACATCTTCTCCAACATCCCACCTGATGGGTTCAAGCAGATCCGACAGGGAATGATCACATTAATCTTGGCCACTGACATG
GCAAGACATGCAGAAATTATGGATTCTTTCAAAGAGAAAATGGAGAATTTTGACTACAGCAACGAGGAGCACATGACCCTGCTGAAGATG
ATTTTGATAAAATGCTGTGATATCTCTAACGAGGTCCGTCCAATGGAAGTCGCAGAGCCTTGGGTGGACTGTTTATTAGAGGAATATTTT
ATGCAGAGCGACCGTGAGAAGTCAGAAGGCCTTCCTGTGGCACCGTTCATGGACCGAGACAAAGTGACCAAGGCCACAGCCCAGATTGGG
TTCATCAAGTTTGTCCTGATCCCAATGTTTGAAACAGTGACCAAGCTCTTCCCCATGGTTGAGGAGATCATGCTGCAGCCACTTTGGGAA
TCCCGAGATCGCTACGAGGAGCTGAAGCGGATAGATGACGCCATGAAAGAGTTACAGAAGAAGACTGACAGCTTGACGTCTGGGGCCACC
GAGAAGTCCAGAGAGAGAAGCAGAGATGTGAAAAACAGTGAAGGAGACTGTGCCTGAGGAAAGCGGGGGGCGTGGCTGCAGTTCTGGACG
GGCTGGCCGAGCTGCGCGGGATCCTTGTGCAGGGAAGAGCTGCCCTGGGCACCTGGCACCACAAGACCATGTTTTCTAAGAACCATTTTG
TTCACTGATACAAAAAAAAAAAAAGGAATTCATGATGCTGTACAGAATTTTATTTTTAAACTGTCTTTTAAATAATATATTCTTATACGG

>92398_92398_1_TMPRSS2-PDE9A_TMPRSS2_chr21_42866283_ENST00000332149_PDE9A_chr21_44163886_ENST00000335512_length(amino acids)=483AA_BP=80
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSMEGLKVVEIEK
CKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSI
NPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP
LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPM
EVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAM

--------------------------------------------------------------
>92398_92398_2_TMPRSS2-PDE9A_TMPRSS2_chr21_42866283_ENST00000332149_PDE9A_chr21_44163886_ENST00000539837_length(transcript)=1800nt_BP=373nt
CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA
CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTAT
GAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTAC
CCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACA
GTGTGCACCTCAATGGAAGGACTAAAAGTGGTGGAGATTGAGAAATGCAAGAGTGACATTAAGAAGATGAGGGAGGAGCTGGCGGCCAGA
AGCAGCAGGACCAACTGCCCCTGTAAGTACAGTTTTTTGGATAACCACAAGAAGTTGACTCCTCGACGCGATGTTCCCACTTACCCCAAG
TACCTGCTCTCTCCAGAGACCATCGAGGCCCTGCGGAAGCCGACCTTTGACGTCTGGCTTTGGGAGCCCAATGAGATGCTGAGCTGCCTG
GAGCACATGTACCACGACCTCGGGCTGGTCAGGGACTTCAGCATCAACCCTGTCACCCTCAGGAGGTGGCTGTTCTGCGTCCACGACAAC
TACAGAAACAACCCCTTCCACAACTTCCGGCACTGCTTCTGCGTGGCCCAGATGATGTACAGCATGGTCTGGCTCTGCAGTCTCCAGGAG
AAGTTCTCACAAACGGATATCCTGATCCTAATGACAGCGGCCATCTGCCACGATCTGGACCATCCCGGCTACAACAACACGTACCAGATC
AATGCCCGCACAGAGCTGGCGGTCCGCTACAATGACATCTCACCGCTGGAGAACCACCACTGCGCCGTGGCCTTCCAGATCCTCGCCGAG
CCTGAGTGCAACATCTTCTCCAACATCCCACCTGATGGGTTCAAGCAGATCCGACAGGGAATGATCACATTAATCTTGGCCACTGACATG
GCAAGACATGCAGAAATTATGGATTCTTTCAAAGAGAAAATGGAGAATTTTGACTACAGCAACGAGGAGCACATGACCCTGCTGAAGATG
ATTTTGATAAAATGCTGTGATATCTCTAACGAGGTCCGTCCAATGGAAGTCGCAGAGCCTTGGGTGGACTGTTTATTAGAGGAATATTTT
ATGCAGAGCGACCGTGAGAAGTCAGAAGGCCTTCCTGTGGCACCGTTCATGGACCGAGACAAAGTGACCAAGGCCACAGCCCAGATTGGG
TTCATCAAGTTTGTCCTGATCCCAATGTTTGAAACAGTGACCAAGCTCTTCCCCATGGTTGAGGAGATCATGCTGCAGCCACTTTGGGAA
TCCCGAGATCGCTACGAGGAGCTGAAGCGGATAGATGACGCCATGAAAGAGTTACAGAAGAAGACTGACAGCTTGACGTCTGGGGCCACC
GAGAAGTCCAGAGAGAGAAGCAGAGATGTGAAAAACAGTGAAGGAGACTGTGCCTGAGGAAAGCGGGGGGCGTGGCTGCAGTTCTGGACG
GGCTGGCCGAGCTGCGCGGGATCCTTGTGCAGGGAAGAGCTGCCCTGGGCACCTGGCACCACAAGACCATGTTTTCTAAGAACCATTTTG
TTCACTGATACAAAAAAAAAAAAAGGAATTCATGATGCTGTACAGAATTTTATTTTTAAACTGTCTTTTAAATAATATATTCTTATACGG

>92398_92398_2_TMPRSS2-PDE9A_TMPRSS2_chr21_42866283_ENST00000332149_PDE9A_chr21_44163886_ENST00000539837_length(amino acids)=483AA_BP=80
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSMEGLKVVEIEK
CKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSI
NPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP
LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPM
EVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAM

--------------------------------------------------------------
>92398_92398_3_TMPRSS2-PDE9A_TMPRSS2_chr21_42866283_ENST00000398585_PDE9A_chr21_44163886_ENST00000335512_length(transcript)=1840nt_BP=410nt
ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG
CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT
GAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGT
CCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCC
CGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAATGGAAGGACTAAAAGTGGTGGAGATTGAGAAATGCAAGAG
TGACATTAAGAAGATGAGGGAGGAGCTGGCGGCCAGAAGCAGCAGGACCAACTGCCCCTGTAAGTACAGTTTTTTGGATAACCACAAGAA
GTTGACTCCTCGACGCGATGTTCCCACTTACCCCAAGTACCTGCTCTCTCCAGAGACCATCGAGGCCCTGCGGAAGCCGACCTTTGACGT
CTGGCTTTGGGAGCCCAATGAGATGCTGAGCTGCCTGGAGCACATGTACCACGACCTCGGGCTGGTCAGGGACTTCAGCATCAACCCTGT
CACCCTCAGGAGGTGGCTGTTCTGCGTCCACGACAACTACAGAAACAACCCCTTCCACAACTTCCGGCACTGCTTCTGCGTGGCCCAGAT
GATGTACAGCATGGTCTGGCTCTGCAGTCTCCAGGAGAAGTTCTCACAAACGGATATCCTGATCCTAATGACAGCGGCCATCTGCCACGA
TCTGGACCATCCCGGCTACAACAACACGTACCAGATCAATGCCCGCACAGAGCTGGCGGTCCGCTACAATGACATCTCACCGCTGGAGAA
CCACCACTGCGCCGTGGCCTTCCAGATCCTCGCCGAGCCTGAGTGCAACATCTTCTCCAACATCCCACCTGATGGGTTCAAGCAGATCCG
ACAGGGAATGATCACATTAATCTTGGCCACTGACATGGCAAGACATGCAGAAATTATGGATTCTTTCAAAGAGAAAATGGAGAATTTTGA
CTACAGCAACGAGGAGCACATGACCCTGCTGAAGATGATTTTGATAAAATGCTGTGATATCTCTAACGAGGTCCGTCCAATGGAAGTCGC
AGAGCCTTGGGTGGACTGTTTATTAGAGGAATATTTTATGCAGAGCGACCGTGAGAAGTCAGAAGGCCTTCCTGTGGCACCGTTCATGGA
CCGAGACAAAGTGACCAAGGCCACAGCCCAGATTGGGTTCATCAAGTTTGTCCTGATCCCAATGTTTGAAACAGTGACCAAGCTCTTCCC
CATGGTTGAGGAGATCATGCTGCAGCCACTTTGGGAATCCCGAGATCGCTACGAGGAGCTGAAGCGGATAGATGACGCCATGAAAGAGTT
ACAGAAGAAGACTGACAGCTTGACGTCTGGGGCCACCGAGAAGTCCAGAGAGAGAAGCAGAGATGTGAAAAACAGTGAAGGAGACTGTGC
CTGAGGAAAGCGGGGGGCGTGGCTGCAGTTCTGGACGGGCTGGCCGAGCTGCGCGGGATCCTTGTGCAGGGAAGAGCTGCCCTGGGCACC
TGGCACCACAAGACCATGTTTTCTAAGAACCATTTTGTTCACTGATACAAAAAAAAAAAAAGGAATTCATGATGCTGTACAGAATTTTAT

>92398_92398_3_TMPRSS2-PDE9A_TMPRSS2_chr21_42866283_ENST00000398585_PDE9A_chr21_44163886_ENST00000335512_length(amino acids)=527AA_BP=124
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSMEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKY
LLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEK
FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMA
RHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGF

--------------------------------------------------------------
>92398_92398_4_TMPRSS2-PDE9A_TMPRSS2_chr21_42866283_ENST00000398585_PDE9A_chr21_44163886_ENST00000539837_length(transcript)=1837nt_BP=410nt
ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG
CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT
GAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGT
CCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCC
CGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAATGGAAGGACTAAAAGTGGTGGAGATTGAGAAATGCAAGAG
TGACATTAAGAAGATGAGGGAGGAGCTGGCGGCCAGAAGCAGCAGGACCAACTGCCCCTGTAAGTACAGTTTTTTGGATAACCACAAGAA
GTTGACTCCTCGACGCGATGTTCCCACTTACCCCAAGTACCTGCTCTCTCCAGAGACCATCGAGGCCCTGCGGAAGCCGACCTTTGACGT
CTGGCTTTGGGAGCCCAATGAGATGCTGAGCTGCCTGGAGCACATGTACCACGACCTCGGGCTGGTCAGGGACTTCAGCATCAACCCTGT
CACCCTCAGGAGGTGGCTGTTCTGCGTCCACGACAACTACAGAAACAACCCCTTCCACAACTTCCGGCACTGCTTCTGCGTGGCCCAGAT
GATGTACAGCATGGTCTGGCTCTGCAGTCTCCAGGAGAAGTTCTCACAAACGGATATCCTGATCCTAATGACAGCGGCCATCTGCCACGA
TCTGGACCATCCCGGCTACAACAACACGTACCAGATCAATGCCCGCACAGAGCTGGCGGTCCGCTACAATGACATCTCACCGCTGGAGAA
CCACCACTGCGCCGTGGCCTTCCAGATCCTCGCCGAGCCTGAGTGCAACATCTTCTCCAACATCCCACCTGATGGGTTCAAGCAGATCCG
ACAGGGAATGATCACATTAATCTTGGCCACTGACATGGCAAGACATGCAGAAATTATGGATTCTTTCAAAGAGAAAATGGAGAATTTTGA
CTACAGCAACGAGGAGCACATGACCCTGCTGAAGATGATTTTGATAAAATGCTGTGATATCTCTAACGAGGTCCGTCCAATGGAAGTCGC
AGAGCCTTGGGTGGACTGTTTATTAGAGGAATATTTTATGCAGAGCGACCGTGAGAAGTCAGAAGGCCTTCCTGTGGCACCGTTCATGGA
CCGAGACAAAGTGACCAAGGCCACAGCCCAGATTGGGTTCATCAAGTTTGTCCTGATCCCAATGTTTGAAACAGTGACCAAGCTCTTCCC
CATGGTTGAGGAGATCATGCTGCAGCCACTTTGGGAATCCCGAGATCGCTACGAGGAGCTGAAGCGGATAGATGACGCCATGAAAGAGTT
ACAGAAGAAGACTGACAGCTTGACGTCTGGGGCCACCGAGAAGTCCAGAGAGAGAAGCAGAGATGTGAAAAACAGTGAAGGAGACTGTGC
CTGAGGAAAGCGGGGGGCGTGGCTGCAGTTCTGGACGGGCTGGCCGAGCTGCGCGGGATCCTTGTGCAGGGAAGAGCTGCCCTGGGCACC
TGGCACCACAAGACCATGTTTTCTAAGAACCATTTTGTTCACTGATACAAAAAAAAAAAAAGGAATTCATGATGCTGTACAGAATTTTAT

>92398_92398_4_TMPRSS2-PDE9A_TMPRSS2_chr21_42866283_ENST00000398585_PDE9A_chr21_44163886_ENST00000539837_length(amino acids)=527AA_BP=124
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSMEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKY
LLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEK
FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMA
RHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMPRSS2-PDE9A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMPRSS2-PDE9A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMPRSS2-PDE9A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource