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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMPRSS3-RSPH1 (FusionGDB2 ID:92410)

Fusion Gene Summary for TMPRSS3-RSPH1

Fusion gene summary

Fusion gene information	Fusion gene name: TMPRSS3-RSPH1
	Fusion gene ID: 92410
		Hgene	Tgene
	Gene symbol	TMPRSS3	RSPH1
	Gene ID	64699	89765
	Gene name	transmembrane serine protease 3	radial spoke head component 1
	Synonyms	DFNB10\|DFNB8\|ECHOS1\|TADG12	CT79\|RSP44\|RSPH10A\|TSA2\|TSGA2
	Cytomap	21q22.3	21q22.3
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protease serine 3serine protease TADG-12transmembrane protease, serine 3tumor-associated differentially-expressed gene 12 protein	radial spoke head 1 homologcancer/testis antigen 79male meiotic metaphase chromosome-associated acidic proteinmeichroacidintestes specific gene A2 homologtestis specific A2 homolog
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000291532, ENST00000380399, ENST00000398405, ENST00000433957, ENST00000474596, ENST00000398397,	ENST00000398352, ENST00000291536,
Fusion gene scores	* DoF score	4 X 4 X 3=48	2 X 2 X 2=8
	# samples	4	2
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: TMPRSS3 [Title/Abstract] AND RSPH1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMPRSS3(43795825)-RSPH1(43913189), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TMPRSS3	GO:0006883	cellular sodium ion homeostasis	12393794

Fusion gene breakpoints across TMPRSS3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RSPH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-44-4112-01A	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-

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Fusion Gene ORF analysis for TMPRSS3-RSPH1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000291532	ENST00000398352	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-
5CDS-intron	ENST00000380399	ENST00000398352	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-
5CDS-intron	ENST00000398405	ENST00000398352	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-
5CDS-intron	ENST00000433957	ENST00000398352	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-
5UTR-3CDS	ENST00000474596	ENST00000291536	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-
5UTR-intron	ENST00000474596	ENST00000398352	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-
Frame-shift	ENST00000291532	ENST00000291536	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-
Frame-shift	ENST00000433957	ENST00000291536	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-
In-frame	ENST00000380399	ENST00000291536	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-
In-frame	ENST00000398405	ENST00000291536	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-
intron-3CDS	ENST00000398397	ENST00000291536	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-
intron-intron	ENST00000398397	ENST00000398352	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000398405	TMPRSS3	chr21	43795825	-	ENST00000291536	RSPH1	chr21	43913189	-	3072	1864	160	2739	859
ENST00000380399	TMPRSS3	chr21	43795825	-	ENST00000291536	RSPH1	chr21	43913189	-	3511	2303	701	3178	825

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000398405	ENST00000291536	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-	0.000508765	0.9994912
ENST00000380399	ENST00000291536	TMPRSS3	chr21	43795825	-	RSPH1	chr21	43913189	-	0.000798056	0.99920195

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Fusion Genomic Features for TMPRSS3-RSPH1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMPRSS3-RSPH1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:43795825/chr21:43913189)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000291532

109_205

449

455.0

Domain

SRCR

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000291532

217_449

449

455.0

Domain

Peptidase S1

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000291532

72_108

449

455.0

Domain

LDL-receptor class A

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000380399

109_205

533

539.0

Domain

SRCR

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000380399

217_449

533

539.0

Domain

Peptidase S1

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000380399

72_108

533

539.0

Domain

LDL-receptor class A

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000433957

109_205

448

454.0

Domain

SRCR

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000433957

217_449

448

454.0

Domain

Peptidase S1

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000433957

72_108

448

454.0

Domain

LDL-receptor class A

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000291532

1_48

449

455.0

Topological domain

Cytoplasmic

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000380399

1_48

533

539.0

Topological domain

Cytoplasmic

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000380399

70_454

533

539.0

Topological domain

Extracellular

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000433957

1_48

448

454.0

Topological domain

Cytoplasmic

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000291532

49_69

449

455.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000380399

49_69

533

539.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000433957

49_69

448

454.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

RSPH1

chr21:43795825

chr21:43913189

ENST00000291536

195_201

310.0

Compositional bias

Note=Poly-Glu

Tgene

RSPH1

chr21:43795825

chr21:43913189

ENST00000291536

298_301

310.0

Compositional bias

Note=Poly-Glu

Tgene

RSPH1

chr21:43795825

chr21:43913189

ENST00000291536

113_135

310.0

Repeat

Note=MORN 5

Tgene

RSPH1

chr21:43795825

chr21:43913189

ENST00000291536

159_181

310.0

Repeat

Note=MORN 6

Tgene

RSPH1

chr21:43795825

chr21:43913189

ENST00000291536

20_43

310.0

Repeat

Note=MORN 1

Tgene

RSPH1

chr21:43795825

chr21:43913189

ENST00000291536

44_66

310.0

Repeat

Note=MORN 2

Tgene

RSPH1

chr21:43795825

chr21:43913189

ENST00000291536

67_89

310.0

Repeat

Note=MORN 3

Tgene

RSPH1

chr21:43795825

chr21:43913189

ENST00000291536

90_112

310.0

Repeat

Note=MORN 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000398397

109_205

345.0

Domain

SRCR

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000398397

217_449

345.0

Domain

Peptidase S1

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000398397

72_108

345.0

Domain

LDL-receptor class A

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000291532

70_454

449

455.0

Topological domain

Extracellular

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000398397

1_48

345.0

Topological domain

Cytoplasmic

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000398397

70_454

345.0

Topological domain

Extracellular

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000433957

70_454

448

454.0

Topological domain

Extracellular

Hgene

TMPRSS3

chr21:43795825

chr21:43913189

ENST00000398397

49_69

345.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Gene Sequence for TMPRSS3-RSPH1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>92410_92410_1_TMPRSS3-RSPH1_TMPRSS3_chr21_43795825_ENST00000380399_RSPH1_chr21_43913189_ENST00000291536_length(transcript)=3511nt_BP=2303nt
TTCTGCTTTTAATGATGGCAGCTCCAGAAATGGTGAGTAAAATGGGTGTGAGGAGAGAAGATGCTTCTCAACACTTCTCAGTGTTGTACA
GCTTGCCAACCACAGCCTGTTTGGGAGGGGATGTTCTCACCCAGGTTCCATCTTTCAGAAGCCATTTGCCCACTTATTCTTTTTATATGG
ATAAACGATGTAATTTGCTACATGCTGATAATAAACAGAGGTATCAGCAAGAATGAAAGCCAGAAAATGGCCCAACATGAACTTCTTGCT
TTTCTAAGTTACTCTTTCAAGCTCTTCTTGCGATAGAAATGAAATGAACATTTTTGGCACAGAACTCTTGTTTAGATTTTACTATGATCT
TGGGAAACACGGGTTGCTTCAAATGGCTTACTAGATCCCTTTGGAATTTCAAACGTTACAACAGGTAGTCACAAAGGGAATGAAAGCGGA
TGATCTGAGTGTCTGTGCTGATGTGCCTGCTGGAGCCCCTGTGGATTTTAGCCCTTGGAGGAAGCAGGTTCCCAGAGCAGCCATGCCTGA
TATCTGGGAGAGGGAACTAGAATTTAATTGGGAATCTTCTGCTATTTCCCTGCTTCCTCCGCCCTCTCAGAGTTACAGGGAATGACTTAG
AAAGGTCTCTGGTCTCCTTGGCATTGTGATAGGTGGAATTCTTTCGTAGGAAACACAGCCCCGGGGTTATTTTGATGCAAGCCGTTGGTC
CAAAGCCACTCCCCACTTTGCTATGTGGGGGAAGGACCGGGCACCGGACGGCTCGGGTACTTTCGTTCTTAATTAGGTCATGCCCGTGTG
AGCCAGGAAAGGGCTGTGTTTATGGGAAGCCAGTAACACTGTGGCCTACTATCTCTTCCGTGGTGCCATCTACATTTTTGGGACTCGGGA
ATTATGAGGTAGAGGTGGAGGCGGAGCCGGATGTCAGAGGTCCTGAAATAGTCACCATGGGGGAAAATGATCCGCCTGCTGTTGAAGCCC
CCTTCTCATTCCGATCGCTTTTTGGCCTTGATGATTTGAAAATAAGTCCTGTTGCACCAGATGCAGATGCTGTTGCTGCACAGATCCTGT
CACTGCTGCCATTGAAGTTTTTTCCAATCATCGTCATTGGGATCATTGCATTGATATTAGCACTGGCCATTGGTCTGGGCATCCACTTCG
ACTGCTCAGGGAAGTACAGATGTCGCTCATCCTTTAAGTGTATCGAGCTGATAGCTCGATGTGACGGAGTCTCGGATTGCAAAGACGGGG
AGGACGAGTACCGCTGTGTCCGGGTGGGTGGTCAGAATGCCGTGCTCCAGGTGTTCACAGCTGCTTCGTGGAAGACCATGTGCTCCGATG
ACTGGAAGGGTCACTACGCAAATGTTGCCTGTGCCCAACTGGGTTTCCCAAGCTATGTGAGTTCAGATAACCTCAGAGTGAGCTCGCTGG
AGGGGCAGTTCCGGGAGGAGTTTGTGTCCATCGATCACCTCTTGCCAGATGACAAGGTGACTGCATTACACCACTCAGTATATGTGAGGG
AGGGATGTGCCTCTGGCCACGTGGTTACCTTGCAGTGCACAGCCTGTGGTCATAGAAGGGGCTACAGCTCACGCATCGTGGGTGGAAACA
TGTCCTTGCTCTCGCAGTGGCCCTGGCAGGCCAGCCTTCAGTTCCAGGGCTACCACCTGTGCGGGGGCTCTGTCATCACGCCCCTGTGGA
TCATCACTGCTGCACACTGTGTTTATGACTTGTACCTCCCCAAGTCATGGACCATCCAGGTGGGTCTAGTTTCCCTGTTGGACAATCCAG
CCCCATCCCACTTGGTGGAGAAGATTGTCTACCACAGCAAGTACAAGCCAAAGAGGCTGGGCAATGACATCGCCCTTATGAAGCTGGCCG
GGCCACTCACGTTCAATGAAATGATCCAGCCTGTGTGCCTGCCCAACTCTGAAGAGAACTTCCCCGATGGAAAAGTGTGCTGGACGTCAG
GATGGGGGGCCACAGAGGATGGAGCAGGTGACGCCTCCCCTGTCCTGAACCACGCGGCCGTCCCTTTGATTTCCAACAAGATCTGCAACC
ACAGGGACGTGTACGGTGGCATCATCTCCCCCTCCATGCTCTGCGCGGGCTACCTGACGGGTGGCGTGGACAGCTGCCAGGGGGACAGCG
GGGGGCCCCTGGTGTGTCAAGAGAGGAGGCTGTGGAAGTTAGTGGGAGCGACCAGCTTTGGCATCGGCTGCGCAGAGGTGAACAAGCCTG
GGGTGTACACCCGTGTCACCTCCTTCCTGGACTGGATCCACGAGCAGATGGAGGAATATGAGGGGGGTCGGAATGAGGCAGGCGAAAGGC
ACGGACGTGGGAGGGCACGGCTACCCAACGGGGACACCTACGAAGGGAGCTACGAATTCGGTAAAAGACATGGCCAGGGGATCTACAAAT
TTAAAAATGGTGCTCGATATATCGGAGAATATGTTAGAAATAAAAAGCACGGTCAAGGCACTTTTATATATCCAGATGGATCCAGATATG
AAGGAGAGTGGGCAAATGACCTGCGGCACGGCCATGGCGTATACTACTACATCAATAATGACACCTACACTGGAGAGTGGTTTGCTCATC
AAAGGCATGGGCAAGGCACCTATTTATACGCGGAGACGGGCAGTAAGTATGTTGGCACCTGGGTGAACGGACAGCAGGAGGGCACGGCCG
AGCTCATTCACCTGAACCACAGGTACCAGGGCAAGTTCTTGAACAAAAATCCTGTTGGCCCTGGAAAGTATGTATTTGATGTTGGGTGTG
AACAACATGGTGAATATCGTTTAACAGATATGGAAAGAGGAGAAGAGGAAGAGGAGGAAGAATTAGTAACTGTTGTTCCAAAATGGAAAG
CTACCCAAATCACTGAATTGGCCCTGTGGACACCAACTCTCCCCAAAAAGCCGACCTCTACGGATGGACCTGGCCAAGACGCTCCAGGAG
CTGAGAGTGCAGGAGAACCCGGGGAGGAGGCCCAGGCTCTGCTGGAGGGCTTCGAGGGTGAGATGGACATGAGGCCTGGAGATGAAGATG
CAGACGTCCTCCGGGAAGAGAGCCGGGAGTATGACCAGGAGGAGTTCCGCTATGACATGGATGAGGGAAACATTAATTCTGAAGAAGAAG
AAACTAGACAGTCAGACCTCCAGGACTAAGATGAAGTGAGCCGAGAGGAGATCGTATCATAAGAATGCTTCTGTCGTTAGCCGGGTGCAG
TGCTGTGTGTATCTAGTTCCAGCTACTTGAGAGGCTGAGGCAGGAGGATTGCTTGAGTCCAGAAAGTGGCAGTTGCAGTGAGTGGAGATC
GCGCCACTGCTCTCCAGCCTGGGTGGCAGAGCGAGACCCTGTCTCAAAAAATAAACAAAAACAAAATGCTTCTGTCAGTTAACAATCTTT
ATTAGAGGGTTTTTAGTCTTTCTTTCTCAGCTGTATGTTAAGTTGATTGACAAATGCAAATAAACGTCTTTATTATCCTTTCTTTCTGAA

>92410_92410_1_TMPRSS3-RSPH1_TMPRSS3_chr21_43795825_ENST00000380399_RSPH1_chr21_43913189_ENST00000291536_length(amino acids)=825AA_BP=534
MMQAVGPKPLPTLLCGGRTGHRTARVLSFLIRSCPCEPGKGCVYGKPVTLWPTISSVVPSTFLGLGNYEVEVEAEPDVRGPEIVTMGEND
PPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGV
SDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALH
HSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLV
SLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLI
SNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMEEYEGGR
NEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYT
GEWFAHQRHGQGTYLYAETGSKYVGTWVNGQQEGTAELIHLNHRYQGKFLNKNPVGPGKYVFDVGCEQHGEYRLTDMERGEEEEEEELVT
VVPKWKATQITELALWTPTLPKKPTSTDGPGQDAPGAESAGEPGEEAQALLEGFEGEMDMRPGDEDADVLREESREYDQEEFRYDMDEGN

--------------------------------------------------------------
>92410_92410_2_TMPRSS3-RSPH1_TMPRSS3_chr21_43795825_ENST00000398405_RSPH1_chr21_43913189_ENST00000291536_length(transcript)=3072nt_BP=1864nt
ATGTGAGTACCGAAACTACTTATGCTTATGGTAGGTGTACCACACGCACAGGGAAAGAATTGCGTTTATGTGGGACAGGTGAAAACAATC
GCAAAAAAGCAATGGAAAGGGCTTTGAGAGTAATTTATCTTCTGAACAATAGCAATATGGCAACTTCTAAATGGTGAGAGGGAGTCCCTC
TAAAGCAATCGATTTGAAGATTGGTTGGACAAACAATGGGAAAGTCATTGTCTTAGCAGAATTAAGTTCATACTTTTTTTTTTTTTTTTT
TTTTGCTAATTCTAGAAGCTTTTCTGTTATCTGCTGTAGCTCAGACGAAAATGCATTCTCACCAGATGACTGTTTTTGGTTAATCGATAC
TGAATGCGCTTTGTGTGGACTGTCGAATTTCAAAGATTTACCGTATGACCAAGATGCACCTGATGCTACAAGTATAAATAGGGGAACAAA
TGCTTTCTGTTCTTCCTCGGCTAAGGAGGTAGAGGTGGAGGCGGAGCCGGATGTCAGAGGTCCTGAAATAGTCACCATGGGGGAAAATGA
TCCGCCTGCTGTTGAAGCCCCCTTCTCATTCCGATCGCTTTTTGGCCTTGATGATTTGAAAATAAGTCCTGTTGCACCAGATGCTGTTGC
TGCACAGATCCTGTCACTGCTGCCATTGAAGTTTTTTCCAATCATCGTCATTGGGATCATTGCATTGATATTAGCACTGGCCATTGGTCT
GGGCATCCACTTCGACTGCTCAGGGAAGTACAGATGTCGCTCATCCTTTAAGTGTATCGAGCTGATAGCTCGATGTGACGGAGTCTCGGA
TTGCAAAGACGGGGAGGACGAGTACCGCTGTGTCCGGGTGGGTGGTCAGAATGCCGTGCTCCAGGTGTTCACAGCTGCTTCGTGGAAGAC
CATGTGCTCCGATGACTGGAAGGGTCACTACGCAAATGTTGCCTGTGCCCAACTGGGTTTCCCAAGCTATGTGAGTTCAGATAACCTCAG
AGTGAGCTCGCTGGAGGGGCAGTTCCGGGAGGAGTTTGTGTCCATCGATCACCTCTTGCCAGATGACAAGGTGACTGCATTACACCACTC
AGTATATGTGAGGGAGGGATGTGCCTCTGGCCACGTGGTTACCTTGCAGTGCACAGCCTGTGGTCATAGAAGGGGCTACAGCTCACGCAT
CGTGGGTGGAAACATGTCCTTGCTCTCGCAGTGGCCCTGGCAGGCCAGCCTTCAGTTCCAGGGCTACCACCTGTGCGGGGGCTCTGTCAT
CACGCCCCTGTGGATCATCACTGCTGCACACTGTGTTTATGACTTGTACCTCCCCAAGTCATGGACCATCCAGGTGGGTCTAGTTTCCCT
GTTGGACAATCCAGCCCCATCCCACTTGGTGGAGAAGATTGTCTACCACAGCAAGTACAAGCCAAAGAGGCTGGGCAATGACATCGCCCT
TATGAAGCTGGCCGGGCCACTCACGTTCAATGAAATGATCCAGCCTGTGTGCCTGCCCAACTCTGAAGAGAACTTCCCCGATGGAAAAGT
GTGCTGGACGTCAGGATGGGGGGCCACAGAGGATGGAGGTGACGCCTCCCCTGTCCTGAACCACGCGGCCGTCCCTTTGATTTCCAACAA
GATCTGCAACCACAGGGACGTGTACGGTGGCATCATCTCCCCCTCCATGCTCTGCGCGGGCTACCTGACGGGTGGCGTGGACAGCTGCCA
GGGGGACAGCGGGGGGCCCCTGGTGTGTCAAGAGAGGAGGCTGTGGAAGTTAGTGGGAGCGACCAGCTTTGGCATCGGCTGCGCAGAGGT
GAACAAGCCTGGGGTGTACACCCGTGTCACCTCCTTCCTGGACTGGATCCACGAGCAGATGGAGGAATATGAGGGGGGTCGGAATGAGGC
AGGCGAAAGGCACGGACGTGGGAGGGCACGGCTACCCAACGGGGACACCTACGAAGGGAGCTACGAATTCGGTAAAAGACATGGCCAGGG
GATCTACAAATTTAAAAATGGTGCTCGATATATCGGAGAATATGTTAGAAATAAAAAGCACGGTCAAGGCACTTTTATATATCCAGATGG
ATCCAGATATGAAGGAGAGTGGGCAAATGACCTGCGGCACGGCCATGGCGTATACTACTACATCAATAATGACACCTACACTGGAGAGTG
GTTTGCTCATCAAAGGCATGGGCAAGGCACCTATTTATACGCGGAGACGGGCAGTAAGTATGTTGGCACCTGGGTGAACGGACAGCAGGA
GGGCACGGCCGAGCTCATTCACCTGAACCACAGGTACCAGGGCAAGTTCTTGAACAAAAATCCTGTTGGCCCTGGAAAGTATGTATTTGA
TGTTGGGTGTGAACAACATGGTGAATATCGTTTAACAGATATGGAAAGAGGAGAAGAGGAAGAGGAGGAAGAATTAGTAACTGTTGTTCC
AAAATGGAAAGCTACCCAAATCACTGAATTGGCCCTGTGGACACCAACTCTCCCCAAAAAGCCGACCTCTACGGATGGACCTGGCCAAGA
CGCTCCAGGAGCTGAGAGTGCAGGAGAACCCGGGGAGGAGGCCCAGGCTCTGCTGGAGGGCTTCGAGGGTGAGATGGACATGAGGCCTGG
AGATGAAGATGCAGACGTCCTCCGGGAAGAGAGCCGGGAGTATGACCAGGAGGAGTTCCGCTATGACATGGATGAGGGAAACATTAATTC
TGAAGAAGAAGAAACTAGACAGTCAGACCTCCAGGACTAAGATGAAGTGAGCCGAGAGGAGATCGTATCATAAGAATGCTTCTGTCGTTA
GCCGGGTGCAGTGCTGTGTGTATCTAGTTCCAGCTACTTGAGAGGCTGAGGCAGGAGGATTGCTTGAGTCCAGAAAGTGGCAGTTGCAGT
GAGTGGAGATCGCGCCACTGCTCTCCAGCCTGGGTGGCAGAGCGAGACCCTGTCTCAAAAAATAAACAAAAACAAAATGCTTCTGTCAGT
TAACAATCTTTATTAGAGGGTTTTTAGTCTTTCTTTCTCAGCTGTATGTTAAGTTGATTGACAAATGCAAATAAACGTCTTTATTATCCT

>92410_92410_2_TMPRSS3-RSPH1_TMPRSS3_chr21_43795825_ENST00000398405_RSPH1_chr21_43913189_ENST00000291536_length(amino acids)=859AA_BP=568
MVRGSPSKAIDLKIGWTNNGKVIVLAELSSYFFFFFFFANSRSFSVICCSSDENAFSPDDCFWLIDTECALCGLSNFKDLPYDQDAPDAT
SINRGTNAFCSSSAKEVEVEAEPDVRGPEIVTMGENDPPAVEAPFSFRSLFGLDDLKISPVAPDAVAAQILSLLPLKFFPIIVIGIIALI
LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGFPSY
VSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH
LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEE
NFPDGKVCWTSGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSF
GIGCAEVNKPGVYTRVTSFLDWIHEQMEEYEGGRNEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKHGQG
TFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAETGSKYVGTWVNGQQEGTAELIHLNHRYQGKFLNKNPVG
PGKYVFDVGCEQHGEYRLTDMERGEEEEEEELVTVVPKWKATQITELALWTPTLPKKPTSTDGPGQDAPGAESAGEPGEEAQALLEGFEG

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Fusion Gene PPI Analysis for TMPRSS3-RSPH1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TMPRSS3-RSPH1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TMPRSS3-RSPH1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source