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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMSB15B-H2BFM (FusionGDB2 ID:92456)

Fusion Gene Summary for TMSB15B-H2BFM

Fusion gene summary

Fusion gene information	Fusion gene name: TMSB15B-H2BFM
	Fusion gene ID: 92456
		Hgene	Tgene
	Gene symbol	TMSB15B	H2BFM
	Gene ID	286527	286436
	Gene name	thymosin beta 15B	H2B.W histone 2
	Synonyms	TMSB15A\|TMSL8\|TMSNB\|Tbeta15b	H2BFM\|H2BM
	Cytomap	Xq22.2	Xq22.2
	Type of gene	protein-coding	protein-coding
	Description	thymosin beta-15BNB thymosin betaThymosin beta-15AThymosin-like protein 8	histone H2B type F-MH2B histone family member MH2B.M histoneH2B/shistone H2B.s
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000419165, ENST00000436583, ENST00000540220, ENST00000563257, ENST00000567181, ENST00000569577, ENST00000455723,	ENST00000243297, ENST00000355016,
Fusion gene scores	* DoF score	3 X 4 X 3=36	2 X 2 X 3=12
	# samples	4	3
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: TMSB15B [Title/Abstract] AND H2BFM [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMSB15B(103219195)-H2BFM(103295394), # samples:103
Anticipated loss of major functional domain due to fusion event.	TMSB15B-H2BFM seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TMSB15B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across H2BFM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-FD-A3SM	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BLCA	TCGA-K4-A3WV	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BLCA	TCGA-XF-AAN7	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BLCA	TCGA-ZF-A9R1	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-A2-A0D2	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-A2-A3XS	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-A2-A3XX	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-A7-A26I	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-A7-A6VY	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-AO-A0J2	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-AR-A2LJ	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-BH-A0BG	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-BH-A18T	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-BH-A1ES	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-C8-A134	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-C8-A27A	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-D8-A142	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-D8-A143	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-D8-A1JG	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-D8-A1JK	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-D8-A1XT	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-E2-A105	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-E2-A14P	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-E9-A22G	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-EW-A6SA	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-LL-A73Z	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-LL-A7T0	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	BRCA	TCGA-S3-A6ZF	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	CESC	TCGA-EA-A1QS	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	CESC	TCGA-FU-A3WB	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	CESC	TCGA-Q1-A73P	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
ChimerDB4	HNSC	TCGA-CQ-7072	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	KIRP	TCGA-BQ-7062	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	KIRP	TCGA-DW-7839	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-CS-6666	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-DB-A64U	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-DH-A669	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-DU-5870	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-DU-6397	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-DU-6404	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-DU-6407	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-DU-7006	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-DU-7018	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-DU-7292	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-DU-8165	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-E1-5304	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-E1-A7YI	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-FG-5963	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-FG-8182	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-FG-A70Z	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-QH-A6CZ	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-QH-A6X5	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-QH-A86X	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-RY-A83X	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-RY-A83Y	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-TM-A7C5	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-TM-A84B	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-TM-A84R	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-TM-A84S	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-TQ-A7RK	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-TQ-A7RN	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LGG	TCGA-WY-A85E	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LIHC	TCGA-CC-A7IJ	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LUAD	TCGA-50-6591	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LUAD	TCGA-86-8054	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LUSC	TCGA-43-7658	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	LUSC	TCGA-52-7809	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	MESO	TCGA-MQ-A4LV	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	MESO	TCGA-SH-A9CU	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
ChimerDB4	PAAD	TCGA-3A-A9IB	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	PAAD	TCGA-3A-A9IV	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	PAAD	TCGA-HZ-8637	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	PAAD	TCGA-IB-AAUS	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	PCPG	TCGA-RM-A68T	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	PCPG	TCGA-RM-A68W	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	PCPG	TCGA-RW-A681	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	PRAD	TCGA-HI-7171	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	SARC	TCGA-FX-A3RE	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	SARC	TCGA-HB-A3YV	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	SARC	TCGA-N1-A6IA	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	SARC	TCGA-SG-A6Z7	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	SARC	TCGA-X6-A7WB	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	SKCM	TCGA-EE-A2MR	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	SKCM	TCGA-ER-A1A1	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	TGCT	TCGA-2G-AAG5	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	TGCT	TCGA-2G-AAGM	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	TGCT	TCGA-2G-AAGP	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	TGCT	TCGA-2G-AAGY	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	TGCT	TCGA-2G-AAH4	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	TGCT	TCGA-2G-AAL5	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	TGCT	TCGA-2G-AALG	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	TGCT	TCGA-2G-AALZ	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	TGCT	TCGA-2G-AAM4	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	THCA	TCGA-DJ-A2Q9	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	THCA	TCGA-FY-A40M	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	THCA	TCGA-J8-A3YH	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	THYM	TCGA-X7-A8DE	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	THYM	TCGA-XU-AAY1	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	UCEC	TCGA-A5-A3LO	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	UCEC	TCGA-AX-A3G6	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	UCEC	TCGA-BG-A3EW	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	UCEC	TCGA-EY-A4KR	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	UCS	TCGA-N5-A4RN	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
ChimerDB4	UCS	TCGA-N6-A4VG	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+

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Fusion Gene ORF analysis for TMSB15B-H2BFM

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000419165	ENST00000243297	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
5UTR-3CDS	ENST00000419165	ENST00000355016	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
5UTR-3CDS	ENST00000436583	ENST00000243297	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
5UTR-3CDS	ENST00000436583	ENST00000355016	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
5UTR-3CDS	ENST00000540220	ENST00000243297	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
5UTR-3CDS	ENST00000540220	ENST00000355016	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
5UTR-3CDS	ENST00000563257	ENST00000243297	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
5UTR-3CDS	ENST00000563257	ENST00000355016	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
5UTR-3CDS	ENST00000567181	ENST00000243297	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
5UTR-3CDS	ENST00000567181	ENST00000355016	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
5UTR-3CDS	ENST00000569577	ENST00000243297	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
5UTR-3CDS	ENST00000569577	ENST00000355016	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
Frame-shift	ENST00000419165	ENST00000243297	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
Frame-shift	ENST00000419165	ENST00000355016	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
Frame-shift	ENST00000436583	ENST00000243297	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
Frame-shift	ENST00000436583	ENST00000355016	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
Frame-shift	ENST00000540220	ENST00000243297	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
Frame-shift	ENST00000540220	ENST00000355016	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
Frame-shift	ENST00000563257	ENST00000243297	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
Frame-shift	ENST00000563257	ENST00000355016	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
Frame-shift	ENST00000567181	ENST00000243297	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
Frame-shift	ENST00000567181	ENST00000355016	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
Frame-shift	ENST00000569577	ENST00000243297	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
Frame-shift	ENST00000569577	ENST00000355016	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
intron-3CDS	ENST00000455723	ENST00000243297	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
intron-3CDS	ENST00000455723	ENST00000243297	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+
intron-3CDS	ENST00000455723	ENST00000355016	TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+
intron-3CDS	ENST00000455723	ENST00000355016	TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for TMSB15B-H2BFM

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+	0.9999231	7.68E-05
TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+	0.9999231	7.68E-05
TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+	0.99926656	0.000733376
TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+	0.99926656	0.000733376
TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+	0.9999231	7.68E-05
TMSB15B	chrX	103217296	+	H2BFM	chrX	103295394	+	0.9999231	7.68E-05
TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+	0.99926656	0.000733376
TMSB15B	chrX	103219195	+	H2BFM	chrX	103295394	+	0.99926656	0.000733376

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMSB15B-H2BFM

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:103219195/:103295394)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for TMSB15B-H2BFM

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TMSB15B-H2BFM

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TMSB15B-H2BFM

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TMSB15B-H2BFM

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source