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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMTC1-YEATS4 (FusionGDB2 ID:92506)

Fusion Gene Summary for TMTC1-YEATS4

check button Fusion gene summary
Fusion gene informationFusion gene name: TMTC1-YEATS4
Fusion gene ID: 92506
HgeneTgene
Gene symbol

TMTC1

YEATS4

Gene ID

83857

8089

Gene nametransmembrane O-mannosyltransferase targeting cadherins 1YEATS domain containing 4
SynonymsARG99|OLF|TMTC1A4930573H17Rik|B230215M10Rik|GAS41|NUBI-1|YAF9
Cytomap

12p11.22

12q15

Type of geneprotein-codingprotein-coding
Descriptionprotein O-mannosyl-transferase TMTC1transmembrane and tetratricopeptide repeat containing 1transmembrane and tetratricopeptide repeat containing 1AYEATS domain-containing protein 4NuMA binding protein 1glioma-amplified sequence 41nuBI1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000319685, ENST00000539277, 
ENST00000551659, ENST00000552618, 
ENST00000256062, ENST00000381224, 
ENST00000247843, ENST00000548020, 
Fusion gene scores* DoF score12 X 13 X 6=93610 X 4 X 4=160
# samples 1310
** MAII scorelog2(13/936*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/160*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMTC1 [Title/Abstract] AND YEATS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMTC1(29709790)-YEATS4(69783927), # samples:2
Anticipated loss of major functional domain due to fusion event.TMTC1-YEATS4 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TMTC1-YEATS4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneYEATS4

GO:0043967

histone H4 acetylation

14966270

TgeneYEATS4

GO:0043968

histone H2A acetylation

14966270


check buttonFusion gene breakpoints across TMTC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across YEATS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A48N-01ATMTC1chr12

29709790

-YEATS4chr12

69783927

+


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Fusion Gene ORF analysis for TMTC1-YEATS4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000319685ENST00000247843TMTC1chr12

29709790

-YEATS4chr12

69783927

+
5UTR-3CDSENST00000319685ENST00000548020TMTC1chr12

29709790

-YEATS4chr12

69783927

+
Frame-shiftENST00000539277ENST00000247843TMTC1chr12

29709790

-YEATS4chr12

69783927

+
Frame-shiftENST00000539277ENST00000548020TMTC1chr12

29709790

-YEATS4chr12

69783927

+
Frame-shiftENST00000551659ENST00000247843TMTC1chr12

29709790

-YEATS4chr12

69783927

+
Frame-shiftENST00000551659ENST00000548020TMTC1chr12

29709790

-YEATS4chr12

69783927

+
Frame-shiftENST00000552618ENST00000247843TMTC1chr12

29709790

-YEATS4chr12

69783927

+
Frame-shiftENST00000552618ENST00000548020TMTC1chr12

29709790

-YEATS4chr12

69783927

+
In-frameENST00000256062ENST00000247843TMTC1chr12

29709790

-YEATS4chr12

69783927

+
In-frameENST00000256062ENST00000548020TMTC1chr12

29709790

-YEATS4chr12

69783927

+
In-frameENST00000381224ENST00000247843TMTC1chr12

29709790

-YEATS4chr12

69783927

+
In-frameENST00000381224ENST00000548020TMTC1chr12

29709790

-YEATS4chr12

69783927

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000256062TMTC1chr1229709790-ENST00000247843YEATS4chr1269783927+247618264651838457
ENST00000256062TMTC1chr1229709790-ENST00000548020YEATS4chr1269783927+231118264651838457
ENST00000381224TMTC1chr1229709790-ENST00000247843YEATS4chr1269783927+266220124652024519
ENST00000381224TMTC1chr1229709790-ENST00000548020YEATS4chr1269783927+249720124652024519

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000256062ENST00000247843TMTC1chr1229709790-YEATS4chr1269783927+0.0125610930.987439
ENST00000256062ENST00000548020TMTC1chr1229709790-YEATS4chr1269783927+0.01758320.98241687
ENST00000381224ENST00000247843TMTC1chr1229709790-YEATS4chr1269783927+0.0058489870.99415094
ENST00000381224ENST00000548020TMTC1chr1229709790-YEATS4chr1269783927+0.008156110.9918439

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Fusion Genomic Features for TMTC1-YEATS4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMTC1chr1229709789-YEATS4chr1269783926+0.001292460.99870753
TMTC1chr1229709789-YEATS4chr1269783926+0.001292460.99870753

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TMTC1-YEATS4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:29709790/chr12:69783927)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018483_516558883.0RepeatNote=TPR 1
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018518_547558883.0RepeatNote=TPR 2
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018111_131450775.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018161_181450775.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018198_218450775.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-101821_41450775.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018314_334450775.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018355_375450775.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018382_402450775.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018404_424450775.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213111_131512575.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213161_181512575.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213198_218512575.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-121321_41512575.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213314_334512575.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213355_375512575.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213382_402512575.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213404_424512575.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213439_459512575.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018111_131558883.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018161_181558883.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018198_218558883.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-101821_41558883.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018314_334558883.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018355_375558883.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018382_402558883.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018404_424558883.0TransmembraneHelical
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018439_459558883.0TransmembraneHelical
TgeneYEATS4chr12:29709790chr12:69783927ENST0000024784357178_226171228.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018483_516450775.0RepeatNote=TPR 1
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018518_547450775.0RepeatNote=TPR 2
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018548_581450775.0RepeatNote=TPR 3
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018583_615450775.0RepeatNote=TPR 4
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018616_649450775.0RepeatNote=TPR 5
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018650_683450775.0RepeatNote=TPR 6
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018684_716450775.0RepeatNote=TPR 7
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018751_784450775.0RepeatNote=TPR 8
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018789_822450775.0RepeatNote=TPR 9
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018823_856450775.0RepeatNote=TPR 10
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213483_516512575.0RepeatNote=TPR 1
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213518_547512575.0RepeatNote=TPR 2
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213548_581512575.0RepeatNote=TPR 3
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213583_615512575.0RepeatNote=TPR 4
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213616_649512575.0RepeatNote=TPR 5
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213650_683512575.0RepeatNote=TPR 6
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213684_716512575.0RepeatNote=TPR 7
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213751_784512575.0RepeatNote=TPR 8
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213789_822512575.0RepeatNote=TPR 9
HgeneTMTC1chr12:29709790chr12:69783927ENST00000381224-1213823_856512575.0RepeatNote=TPR 10
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018548_581558883.0RepeatNote=TPR 3
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018583_615558883.0RepeatNote=TPR 4
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018616_649558883.0RepeatNote=TPR 5
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018650_683558883.0RepeatNote=TPR 6
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018684_716558883.0RepeatNote=TPR 7
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018751_784558883.0RepeatNote=TPR 8
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018789_822558883.0RepeatNote=TPR 9
HgeneTMTC1chr12:29709790chr12:69783927ENST00000539277-1018823_856558883.0RepeatNote=TPR 10
HgeneTMTC1chr12:29709790chr12:69783927ENST00000256062-1018439_459450775.0TransmembraneHelical
TgeneYEATS4chr12:29709790chr12:69783927ENST000002478435715_158171228.0DomainYEATS
TgeneYEATS4chr12:29709790chr12:69783927ENST000002478435793_97171228.0RegionDiacetylated histone H3 binding


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Fusion Gene Sequence for TMTC1-YEATS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92506_92506_1_TMTC1-YEATS4_TMTC1_chr12_29709790_ENST00000256062_YEATS4_chr12_69783927_ENST00000247843_length(transcript)=2476nt_BP=1826nt
AGATAGAAAAAGTAGTTTGCTTGGCATCTCCCAAATTATCTTGAGCAAACAATAAAATAAGAAATGTTTCAGAAGACAATTCGGCTCCCA
GGCCCAAACCAAAACTCGAACCTGGTACTTTTTGTAAGTGCGGGCCAAGAAAGGGGCTGTAAAGTTAAAGAGCCGGTGGCGCCTCTGAAC
ACACCCGGGCAGGGCGAGCAGGATGTCCTTGTCCAGGGAGACCCCTTCTCCTGGCTTTGAGGAAGGTGCTCCCTATCCCCGCGGGTTCCT
CCGCCAAGCGGGACGCCGCGCCGGGCGGGTGAGAGAAAGCCCGGGCAGGAGAGCACAGAGCCGGCGACTGGACGCGAGCGCGGGGCGGGT
GGAGAGCGTCTCTCCGGGCGCCGCTGCTGTTGTCCCGGGTGCTGAAAAGCCGGGAACTTCCCGGGAAGCAGCGGCACTTTTCTCCCTGGA
AGGCTAAACATATTTTTGACTGGTATGAACCCATTCTACTTTCATGCAGTAAATATAATTTTACACTGCTTAGTGACTCTTGTGCTGATG
TACACCTGTGATAAAACTGTCTTCAAGAATCGTGGACTTGCTTTTGTAACGGCATTGCTTTTTGCTGTACATCCTATTCATACTGAGGCG
GTGGCTGGGATCGTTGGCAGAGCGGACGTGTTAGCGTGTCTGCTGTTTCTATTGGCCTTTCTCTCGTACAACAGGAGTCTGGATCAGGGC
TGTGTTGGGGGAAGTTTCCCTTCCACGGTGTCTCCCTTCTTCTTGCTGCTCAGTTTGTTTCTGGGGACCTGTGCGATGCTGGTGAAAGAG
ACAGGCATCACGGTGTTTGGAGTGTGCTTGGTTTATGACCTCTTTTCCCTTTCCAACAAGCAAGACAAGTCGAGCAATGGGGCCCTCTGT
CCACGCAGCCCACAGCAGCCCGGGAGCCCCCAGCCCTCCTCACTGCCAGGCCATCCTCACCGGGAGAATGGGAAGCAGCAGCGGTTCCCT
CACAAAGGAGCTTGGGGTGGCTGCCACTCTCCACTGCCACCAGAACCCAAGAGCAGTGGATTCCCAGTGTCCCCACGAGCTGTGTGGTCC
ATGATGAGATTCCTCACCTATTCCTACCTCTTGGCCTTCAATGTGTGGCTTCTGCTTGCACCCGTGACCCTGTGCTATGACTGGCAGGTC
GGCAGTATTCCTCTGGTAGAGACCATATGGGACATGCGGAACTTAGCCACCATCTTTCTGGCGGTTGTGATGGCCTTATTGAGCCTGCAC
TGCTTAGCAGCCTTTAAGAGACTGGAGCACAAGGAGGTTTTAGTCGGCTTGTTGTTCCTGGTGTTCCCGTTCATTCCAGCCAGCAACCTC
TTCTTCAGGGTGGGTTTTGTGGTGGCGGAGAGAGTCCTTTACATGCCTAGCATGGGCTACTGCATCCTTTTTGTGCATGGACTGAGCAAG
CTCTGCACTTGGCTGAATCGATGTGGGGCCACCACCCTGATTGTGTCCACTGTGTTGCTGCTGTTGCTTTTCTCTTGGAAAACTGTGAAA
CAGAATGAAATTTGGCTGTCAAGAGAGTCCCTATTCAGGTCTGGAGTTCAAACTCTGCCCCACAATGCCAAGGTTCACTACAACTATGCC
AATTTCCTGAAGGACCAAGGTCGGAACAAGGAAGCGATCTACCACTACAGAACAGCTCTCAAGTTGTATCCACGCCATGCAAGTGCGCTC
AACAACCTTGGAACACTGACGAGAGACACAGCAGAGGCAAAGATGTACTATCAGAGGGCTCTCCAGCTCCATCCACAGCATAACCGGGCT
CTTTTCAATCTGGGGAATCTCCTCAATTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGA
GATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATGACCA
AGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTTACTG
CAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGCAATC
TTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCACAGTTT
TTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATCAAAATTTCATTATAAAGTATTACTTGTACAAATTTT
GTACTTCTTTAGTGGCTAGAATTAGTGAAGAAACTTAATGTGTATATTTAATTTCTTCAAGTTCTTACCTGCCCCCATCCTTTTTTGTAT

>92506_92506_1_TMTC1-YEATS4_TMTC1_chr12_29709790_ENST00000256062_YEATS4_chr12_69783927_ENST00000247843_length(amino acids)=457AA_BP=
MTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGS
FPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAW
GGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAF
KRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIW
LSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLG

--------------------------------------------------------------
>92506_92506_2_TMTC1-YEATS4_TMTC1_chr12_29709790_ENST00000256062_YEATS4_chr12_69783927_ENST00000548020_length(transcript)=2311nt_BP=1826nt
AGATAGAAAAAGTAGTTTGCTTGGCATCTCCCAAATTATCTTGAGCAAACAATAAAATAAGAAATGTTTCAGAAGACAATTCGGCTCCCA
GGCCCAAACCAAAACTCGAACCTGGTACTTTTTGTAAGTGCGGGCCAAGAAAGGGGCTGTAAAGTTAAAGAGCCGGTGGCGCCTCTGAAC
ACACCCGGGCAGGGCGAGCAGGATGTCCTTGTCCAGGGAGACCCCTTCTCCTGGCTTTGAGGAAGGTGCTCCCTATCCCCGCGGGTTCCT
CCGCCAAGCGGGACGCCGCGCCGGGCGGGTGAGAGAAAGCCCGGGCAGGAGAGCACAGAGCCGGCGACTGGACGCGAGCGCGGGGCGGGT
GGAGAGCGTCTCTCCGGGCGCCGCTGCTGTTGTCCCGGGTGCTGAAAAGCCGGGAACTTCCCGGGAAGCAGCGGCACTTTTCTCCCTGGA
AGGCTAAACATATTTTTGACTGGTATGAACCCATTCTACTTTCATGCAGTAAATATAATTTTACACTGCTTAGTGACTCTTGTGCTGATG
TACACCTGTGATAAAACTGTCTTCAAGAATCGTGGACTTGCTTTTGTAACGGCATTGCTTTTTGCTGTACATCCTATTCATACTGAGGCG
GTGGCTGGGATCGTTGGCAGAGCGGACGTGTTAGCGTGTCTGCTGTTTCTATTGGCCTTTCTCTCGTACAACAGGAGTCTGGATCAGGGC
TGTGTTGGGGGAAGTTTCCCTTCCACGGTGTCTCCCTTCTTCTTGCTGCTCAGTTTGTTTCTGGGGACCTGTGCGATGCTGGTGAAAGAG
ACAGGCATCACGGTGTTTGGAGTGTGCTTGGTTTATGACCTCTTTTCCCTTTCCAACAAGCAAGACAAGTCGAGCAATGGGGCCCTCTGT
CCACGCAGCCCACAGCAGCCCGGGAGCCCCCAGCCCTCCTCACTGCCAGGCCATCCTCACCGGGAGAATGGGAAGCAGCAGCGGTTCCCT
CACAAAGGAGCTTGGGGTGGCTGCCACTCTCCACTGCCACCAGAACCCAAGAGCAGTGGATTCCCAGTGTCCCCACGAGCTGTGTGGTCC
ATGATGAGATTCCTCACCTATTCCTACCTCTTGGCCTTCAATGTGTGGCTTCTGCTTGCACCCGTGACCCTGTGCTATGACTGGCAGGTC
GGCAGTATTCCTCTGGTAGAGACCATATGGGACATGCGGAACTTAGCCACCATCTTTCTGGCGGTTGTGATGGCCTTATTGAGCCTGCAC
TGCTTAGCAGCCTTTAAGAGACTGGAGCACAAGGAGGTTTTAGTCGGCTTGTTGTTCCTGGTGTTCCCGTTCATTCCAGCCAGCAACCTC
TTCTTCAGGGTGGGTTTTGTGGTGGCGGAGAGAGTCCTTTACATGCCTAGCATGGGCTACTGCATCCTTTTTGTGCATGGACTGAGCAAG
CTCTGCACTTGGCTGAATCGATGTGGGGCCACCACCCTGATTGTGTCCACTGTGTTGCTGCTGTTGCTTTTCTCTTGGAAAACTGTGAAA
CAGAATGAAATTTGGCTGTCAAGAGAGTCCCTATTCAGGTCTGGAGTTCAAACTCTGCCCCACAATGCCAAGGTTCACTACAACTATGCC
AATTTCCTGAAGGACCAAGGTCGGAACAAGGAAGCGATCTACCACTACAGAACAGCTCTCAAGTTGTATCCACGCCATGCAAGTGCGCTC
AACAACCTTGGAACACTGACGAGAGACACAGCAGAGGCAAAGATGTACTATCAGAGGGCTCTCCAGCTCCATCCACAGCATAACCGGGCT
CTTTTCAATCTGGGGAATCTCCTCAATTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAGCTTTGA
GATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGATGACCA
AGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGACTTACTG
CAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAAGCAATC
TTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCACAGTTT

>92506_92506_2_TMTC1-YEATS4_TMTC1_chr12_29709790_ENST00000256062_YEATS4_chr12_69783927_ENST00000548020_length(amino acids)=457AA_BP=
MTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGS
FPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAW
GGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAF
KRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIW
LSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLG

--------------------------------------------------------------
>92506_92506_3_TMTC1-YEATS4_TMTC1_chr12_29709790_ENST00000381224_YEATS4_chr12_69783927_ENST00000247843_length(transcript)=2662nt_BP=2012nt
AGATAGAAAAAGTAGTTTGCTTGGCATCTCCCAAATTATCTTGAGCAAACAATAAAATAAGAAATGTTTCAGAAGACAATTCGGCTCCCA
GGCCCAAACCAAAACTCGAACCTGGTACTTTTTGTAAGTGCGGGCCAAGAAAGGGGCTGTAAAGTTAAAGAGCCGGTGGCGCCTCTGAAC
ACACCCGGGCAGGGCGAGCAGGATGTCCTTGTCCAGGGAGACCCCTTCTCCTGGCTTTGAGGAAGGTGCTCCCTATCCCCGCGGGTTCCT
CCGCCAAGCGGGACGCCGCGCCGGGCGGGTGAGAGAAAGCCCGGGCAGGAGAGCACAGAGCCGGCGACTGGACGCGAGCGCGGGGCGGGT
GGAGAGCGTCTCTCCGGGCGCCGCTGCTGTTGTCCCGGGTGCTGAAAAGCCGGGAACTTCCCGGGAAGCAGCGGCACTTTTCTCCCTGGA
AGGCTAAACATATTTTTGACTGGTATGAACCCATTCTACTTTCATGCAGTAAATATAATTTTACACTGCTTAGTGACTCTTGTGCTGATG
TACACCTGTGATAAAACTGTCTTCAAGAATCGTGGACTTGCTTTTGTAACGGCATTGCTTTTTGCTGTACATCCTATTCATACTGAGGCG
GTGGCTGGGATCGTTGGCAGAGCGGACGTGTTAGCGTGTCTGCTGTTTCTATTGGCCTTTCTCTCGTACAACAGGAGTCTGGATCAGGGC
TGTGTTGGGGGAAGTTTCCCTTCCACGGTGTCTCCCTTCTTCTTGCTGCTCAGTTTGTTTCTGGGGACCTGTGCGATGCTGGTGAAAGAG
ACAGGCATCACGGTGTTTGGAGTGTGCTTGGTTTATGACCTCTTTTCCCTTTCCAACAAGCAAGACAAGTCGAGCAATGGGGCCCTCTGT
CCACGCAGCCCACAGCAGCCCGGGAGCCCCCAGCCCTCCTCACTGCCAGGCCATCCTCACCGGGAGAATGGGAAGCAGCAGCGGTTCCCT
CACAAAGGAGCTTGGGGTGGCTGCCACTCTCCACTGCCACCAGAACCCAAGAGCAGTGGATTCCCAGTGTCCCCACGAGCTGTGTGGTCC
ATGATGAGGTATCTGAGAGCAAGCAGCAATAGAAATTTCCTGCTTACCATGAGACCATTTTTAAAAAGGGCCATTTTGGTCCTAAGTTAT
GTGCTTGTCATTTTGTACTTCCGTCTGTGGATAATGGGAGGATCTATGCCCCTCTTTTCAGAGCAGGATAATCCAGCTTCATTTTCGCCT
TACATTCTTACGAGATTCCTCACCTATTCCTACCTCTTGGCCTTCAATGTGTGGCTTCTGCTTGCACCCGTGACCCTGTGCTATGACTGG
CAGGTCGGCAGTATTCCTCTGGTAGAGACCATATGGGACATGCGGAACTTAGCCACCATCTTTCTGGCGGTTGTGATGGCCTTATTGAGC
CTGCACTGCTTAGCAGCCTTTAAGAGACTGGAGCACAAGGAGGTTTTAGTCGGCTTGTTGTTCCTGGTGTTCCCGTTCATTCCAGCCAGC
AACCTCTTCTTCAGGGTGGGTTTTGTGGTGGCGGAGAGAGTCCTTTACATGCCTAGCATGGGCTACTGCATCCTTTTTGTGCATGGACTG
AGCAAGCTCTGCACTTGGCTGAATCGATGTGGGGCCACCACCCTGATTGTGTCCACTGTGTTGCTGCTGTTGCTTTTCTCTTGGAAAACT
GTGAAACAGAATGAAATTTGGCTGTCAAGAGAGTCCCTATTCAGGTCTGGAGTTCAAACTCTGCCCCACAATGCCAAGGTTCACTACAAC
TATGCCAATTTCCTGAAGGACCAAGGTCGGAACAAGGAAGCGATCTACCACTACAGAACAGCTCTCAAGTTGTATCCACGCCATGCAAGT
GCGCTCAACAACCTTGGAACACTGACGAGAGACACAGCAGAGGCAAAGATGTACTATCAGAGGGCTCTCCAGCTCCATCCACAGCATAAC
CGGGCTCTTTTCAATCTGGGGAATCTCCTCAATTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAG
CTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGA
TGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGAC
TTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAA
GCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCA
CAGTTTTTAAAAATGTTTATTGTAGTATATGTATAGCTTATTACCCTTTTGACAGGCATCAAAATTTCATTATAAAGTATTACTTGTACA
AATTTTGTACTTCTTTAGTGGCTAGAATTAGTGAAGAAACTTAATGTGTATATTTAATTTCTTCAAGTTCTTACCTGCCCCCATCCTTTT

>92506_92506_3_TMTC1-YEATS4_TMTC1_chr12_29709790_ENST00000381224_YEATS4_chr12_69783927_ENST00000247843_length(amino acids)=519AA_BP=
MTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGS
FPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAW
GGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTR
FLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFR
VGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFL

--------------------------------------------------------------
>92506_92506_4_TMTC1-YEATS4_TMTC1_chr12_29709790_ENST00000381224_YEATS4_chr12_69783927_ENST00000548020_length(transcript)=2497nt_BP=2012nt
AGATAGAAAAAGTAGTTTGCTTGGCATCTCCCAAATTATCTTGAGCAAACAATAAAATAAGAAATGTTTCAGAAGACAATTCGGCTCCCA
GGCCCAAACCAAAACTCGAACCTGGTACTTTTTGTAAGTGCGGGCCAAGAAAGGGGCTGTAAAGTTAAAGAGCCGGTGGCGCCTCTGAAC
ACACCCGGGCAGGGCGAGCAGGATGTCCTTGTCCAGGGAGACCCCTTCTCCTGGCTTTGAGGAAGGTGCTCCCTATCCCCGCGGGTTCCT
CCGCCAAGCGGGACGCCGCGCCGGGCGGGTGAGAGAAAGCCCGGGCAGGAGAGCACAGAGCCGGCGACTGGACGCGAGCGCGGGGCGGGT
GGAGAGCGTCTCTCCGGGCGCCGCTGCTGTTGTCCCGGGTGCTGAAAAGCCGGGAACTTCCCGGGAAGCAGCGGCACTTTTCTCCCTGGA
AGGCTAAACATATTTTTGACTGGTATGAACCCATTCTACTTTCATGCAGTAAATATAATTTTACACTGCTTAGTGACTCTTGTGCTGATG
TACACCTGTGATAAAACTGTCTTCAAGAATCGTGGACTTGCTTTTGTAACGGCATTGCTTTTTGCTGTACATCCTATTCATACTGAGGCG
GTGGCTGGGATCGTTGGCAGAGCGGACGTGTTAGCGTGTCTGCTGTTTCTATTGGCCTTTCTCTCGTACAACAGGAGTCTGGATCAGGGC
TGTGTTGGGGGAAGTTTCCCTTCCACGGTGTCTCCCTTCTTCTTGCTGCTCAGTTTGTTTCTGGGGACCTGTGCGATGCTGGTGAAAGAG
ACAGGCATCACGGTGTTTGGAGTGTGCTTGGTTTATGACCTCTTTTCCCTTTCCAACAAGCAAGACAAGTCGAGCAATGGGGCCCTCTGT
CCACGCAGCCCACAGCAGCCCGGGAGCCCCCAGCCCTCCTCACTGCCAGGCCATCCTCACCGGGAGAATGGGAAGCAGCAGCGGTTCCCT
CACAAAGGAGCTTGGGGTGGCTGCCACTCTCCACTGCCACCAGAACCCAAGAGCAGTGGATTCCCAGTGTCCCCACGAGCTGTGTGGTCC
ATGATGAGGTATCTGAGAGCAAGCAGCAATAGAAATTTCCTGCTTACCATGAGACCATTTTTAAAAAGGGCCATTTTGGTCCTAAGTTAT
GTGCTTGTCATTTTGTACTTCCGTCTGTGGATAATGGGAGGATCTATGCCCCTCTTTTCAGAGCAGGATAATCCAGCTTCATTTTCGCCT
TACATTCTTACGAGATTCCTCACCTATTCCTACCTCTTGGCCTTCAATGTGTGGCTTCTGCTTGCACCCGTGACCCTGTGCTATGACTGG
CAGGTCGGCAGTATTCCTCTGGTAGAGACCATATGGGACATGCGGAACTTAGCCACCATCTTTCTGGCGGTTGTGATGGCCTTATTGAGC
CTGCACTGCTTAGCAGCCTTTAAGAGACTGGAGCACAAGGAGGTTTTAGTCGGCTTGTTGTTCCTGGTGTTCCCGTTCATTCCAGCCAGC
AACCTCTTCTTCAGGGTGGGTTTTGTGGTGGCGGAGAGAGTCCTTTACATGCCTAGCATGGGCTACTGCATCCTTTTTGTGCATGGACTG
AGCAAGCTCTGCACTTGGCTGAATCGATGTGGGGCCACCACCCTGATTGTGTCCACTGTGTTGCTGCTGTTGCTTTTCTCTTGGAAAACT
GTGAAACAGAATGAAATTTGGCTGTCAAGAGAGTCCCTATTCAGGTCTGGAGTTCAAACTCTGCCCCACAATGCCAAGGTTCACTACAAC
TATGCCAATTTCCTGAAGGACCAAGGTCGGAACAAGGAAGCGATCTACCACTACAGAACAGCTCTCAAGTTGTATCCACGCCATGCAAGT
GCGCTCAACAACCTTGGAACACTGACGAGAGACACAGCAGAGGCAAAGATGTACTATCAGAGGGCTCTCCAGCTCCATCCACAGCATAAC
CGGGCTCTTTTCAATCTGGGGAATCTCCTCAATTGCAGAGCTTGAAGTGAAAACCAGAGAAAAATTAGAAGCTGCTAAGAAAAAAACAAG
CTTTGAGATTGCAGAGCTTAAGGAGAGATTAAAAGCAAGTCGTGAAACTATAAATTGTTTAAAAAATGAAATCAGAAAACTTGAAGAAGA
TGACCAAGCAAAAGACATATAAACAGTTCTCATGAGAACTTGGTAGTAAGCTAAACTGAAAATAAGGTGGGCTTCACTGGAGAAATGGAC
TTACTGCAAATGCTGTGATGTTTCTTAGAGGAACTTCATATACAGCTGTTGACCATGAATTTCTTAGCAATAGGAATTTGTACTATTTAA
GCAATCTTTAATGGAAAATATGTGTGTAAGAATGGATGCTATATAGGTATTTTACCAACCCATTTTAAGAAAATTCTATGATATTAAGCA

>92506_92506_4_TMTC1-YEATS4_TMTC1_chr12_29709790_ENST00000381224_YEATS4_chr12_69783927_ENST00000548020_length(amino acids)=519AA_BP=
MTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGS
FPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAW
GGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTR
FLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFR
VGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMTC1-YEATS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneYEATS4chr12:29709790chr12:69783927ENST0000024784357163_227171.33333333333334228.0MLLT10
TgeneYEATS4chr12:29709790chr12:69783927ENST0000024784357168_227171.33333333333334228.0TACC1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMTC1-YEATS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMTC1-YEATS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource