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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMTC2-CPSF6 (FusionGDB2 ID:92510)

Fusion Gene Summary for TMTC2-CPSF6

check button Fusion gene summary
Fusion gene informationFusion gene name: TMTC2-CPSF6
Fusion gene ID: 92510
HgeneTgene
Gene symbol

TMTC2

CPSF6

Gene ID

160335

11052

Gene nametransmembrane O-mannosyltransferase targeting cadherins 2cleavage and polyadenylation specific factor 6
SynonymsIBDBP1CFIM|CFIM68|CFIM72|HPBRII-4|HPBRII-7
Cytomap

12q21.31

12q15

Type of geneprotein-codingprotein-coding
Descriptionprotein O-mannosyl-transferase TMTC2transmembrane and TPR repeat-containing protein 2transmembrane and tetratricopeptide repeat containing 2cleavage and polyadenylation specificity factor subunit 6CPSF 68 kDa subunitcleavage and polyadenylation specific factor 6, 68kDacleavage and polyadenylation specificity factor 68 kDa subunitcleavage factor Im complex 68 kDa subunitpre-mRNA cleavage
Modification date2020032920200313
UniProtAcc.

Q16630

Ensembl transtripts involved in fusion geneENST00000321196, ENST00000548305, 
ENST00000549919, 		ENST00000550987, 
ENST00000551516, ENST00000266679, 
ENST00000435070, ENST00000456847, 
Fusion gene scores* DoF score11 X 7 X 5=38513 X 12 X 11=1716
# samples 1117
** MAII scorelog2(11/385*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1716*10)=-3.33544290136184
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMTC2 [Title/Abstract] AND CPSF6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCPSF6(69633486)-TMTC2(83250789), # samples:3
TMTC2(83251359)-CPSF6(69644909), # samples:1
Anticipated loss of major functional domain due to fusion event.CPSF6-TMTC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCPSF6

GO:0006397

mRNA processing

14690600

TgeneCPSF6

GO:0051262

protein tetramerization

20695905

TgeneCPSF6

GO:0051290

protein heterotetramerization

23187700

TgeneCPSF6

GO:1990120

messenger ribonucleoprotein complex assembly

29276085


check buttonFusion gene breakpoints across TMTC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CPSF6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-26-1442-01ATMTC2chr12

83251359

+CPSF6chr12

69644909

+


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Fusion Gene ORF analysis for TMTC2-CPSF6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000321196ENST00000550987TMTC2chr12

83251359

+CPSF6chr12

69644909

+
5CDS-3UTRENST00000321196ENST00000551516TMTC2chr12

83251359

+CPSF6chr12

69644909

+
5CDS-3UTRENST00000548305ENST00000550987TMTC2chr12

83251359

+CPSF6chr12

69644909

+
5CDS-3UTRENST00000548305ENST00000551516TMTC2chr12

83251359

+CPSF6chr12

69644909

+
5CDS-3UTRENST00000549919ENST00000550987TMTC2chr12

83251359

+CPSF6chr12

69644909

+
5CDS-3UTRENST00000549919ENST00000551516TMTC2chr12

83251359

+CPSF6chr12

69644909

+
In-frameENST00000321196ENST00000266679TMTC2chr12

83251359

+CPSF6chr12

69644909

+
In-frameENST00000321196ENST00000435070TMTC2chr12

83251359

+CPSF6chr12

69644909

+
In-frameENST00000321196ENST00000456847TMTC2chr12

83251359

+CPSF6chr12

69644909

+
In-frameENST00000548305ENST00000266679TMTC2chr12

83251359

+CPSF6chr12

69644909

+
In-frameENST00000548305ENST00000435070TMTC2chr12

83251359

+CPSF6chr12

69644909

+
In-frameENST00000548305ENST00000456847TMTC2chr12

83251359

+CPSF6chr12

69644909

+
In-frameENST00000549919ENST00000266679TMTC2chr12

83251359

+CPSF6chr12

69644909

+
In-frameENST00000549919ENST00000435070TMTC2chr12

83251359

+CPSF6chr12

69644909

+
In-frameENST00000549919ENST00000456847TMTC2chr12

83251359

+CPSF6chr12

69644909

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000321196TMTC2chr1283251359+ENST00000435070CPSF6chr1269644909+780713616502956768
ENST00000321196TMTC2chr1283251359+ENST00000456847CPSF6chr1269644909+316913616502737695
ENST00000321196TMTC2chr1283251359+ENST00000266679CPSF6chr1269644909+349913616503067805
ENST00000548305TMTC2chr1283251359+ENST00000435070CPSF6chr1269644909+768612405292835768
ENST00000548305TMTC2chr1283251359+ENST00000456847CPSF6chr1269644909+304812405292616695
ENST00000548305TMTC2chr1283251359+ENST00000266679CPSF6chr1269644909+337812405292946805
ENST00000549919TMTC2chr1283251359+ENST00000435070CPSF6chr1269644909+8887244116704036788
ENST00000549919TMTC2chr1283251359+ENST00000456847CPSF6chr1269644909+4249244116703817715
ENST00000549919TMTC2chr1283251359+ENST00000266679CPSF6chr1269644909+4579244116704147825

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000321196ENST00000435070TMTC2chr1283251359+CPSF6chr1269644909+0.000500740.9994992
ENST00000321196ENST00000456847TMTC2chr1283251359+CPSF6chr1269644909+0.0035860670.996414
ENST00000321196ENST00000266679TMTC2chr1283251359+CPSF6chr1269644909+0.0025533720.99744666
ENST00000548305ENST00000435070TMTC2chr1283251359+CPSF6chr1269644909+0.0004617560.9995383
ENST00000548305ENST00000456847TMTC2chr1283251359+CPSF6chr1269644909+0.0034147950.99658513
ENST00000548305ENST00000266679TMTC2chr1283251359+CPSF6chr1269644909+0.0024946840.99750537
ENST00000549919ENST00000435070TMTC2chr1283251359+CPSF6chr1269644909+0.0002688210.9997311
ENST00000549919ENST00000456847TMTC2chr1283251359+CPSF6chr1269644909+0.000744550.9992555
ENST00000549919ENST00000266679TMTC2chr1283251359+CPSF6chr1269644909+0.0007706530.9992293

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Fusion Genomic Features for TMTC2-CPSF6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMTC2chr1283251359+CPSF6chr1269644908+6.88E-070.9999993
TMTC2chr1283251359+CPSF6chr1269644908+6.88E-070.9999993

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TMTC2-CPSF6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69633486/chr12:83250789)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CPSF6

Q16630

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460). {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.; FUNCTION: (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro). {ECO:0000269|PubMed:24130490}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212108_128218837.0TransmembraneHelical
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212133_153218837.0TransmembraneHelical
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212163_183218837.0TransmembraneHelical
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212184_204218837.0TransmembraneHelical
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+21285_105218837.0TransmembraneHelical
TgeneCPSF6chr12:83251359chr12:69644909ENST00000266679011208_39820701.3333333333334Compositional biasNote=Pro-rich
TgeneCPSF6chr12:83251359chr12:69644909ENST00000266679011490_55120701.3333333333334Compositional biasNote=Arg-rich
TgeneCPSF6chr12:83251359chr12:69644909ENST00000435070010208_398202111.0Compositional biasNote=Pro-rich
TgeneCPSF6chr12:83251359chr12:69644909ENST00000435070010490_551202111.0Compositional biasNote=Arg-rich
TgeneCPSF6chr12:83251359chr12:69644909ENST00000266679011202_20620701.3333333333334MotifGAR
TgeneCPSF6chr12:83251359chr12:69644909ENST00000435070010202_206202111.0MotifGAR
TgeneCPSF6chr12:83251359chr12:69644909ENST00000266679011358_55120701.3333333333334Region(Microbial infection) Binds to HIV-1 capsid protein p24 (CA)
TgeneCPSF6chr12:83251359chr12:69644909ENST00000266679011404_55120701.3333333333334RegionSufficient for nuclear speckle localization
TgeneCPSF6chr12:83251359chr12:69644909ENST00000266679011405_55120701.3333333333334RegionNecessary for RNA-binding
TgeneCPSF6chr12:83251359chr12:69644909ENST00000266679011510_55120701.3333333333334RegionSufficient for nuclear targeting
TgeneCPSF6chr12:83251359chr12:69644909ENST0000026667901181_16120701.3333333333334RegionNecessary for nuclear paraspeckles localization
TgeneCPSF6chr12:83251359chr12:69644909ENST00000435070010358_551202111.0Region(Microbial infection) Binds to HIV-1 capsid protein p24 (CA)
TgeneCPSF6chr12:83251359chr12:69644909ENST00000435070010404_551202111.0RegionSufficient for nuclear speckle localization
TgeneCPSF6chr12:83251359chr12:69644909ENST00000435070010405_551202111.0RegionNecessary for RNA-binding
TgeneCPSF6chr12:83251359chr12:69644909ENST00000435070010510_551202111.0RegionSufficient for nuclear targeting
TgeneCPSF6chr12:83251359chr12:69644909ENST0000043507001081_161202111.0RegionNecessary for nuclear paraspeckles localization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212462_492218837.0RepeatNote=TPR 1
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212493_526218837.0RepeatNote=TPR 2
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212527_560218837.0RepeatNote=TPR 3
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212562_594218837.0RepeatNote=TPR 4
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212606_639218837.0RepeatNote=TPR 5
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212643_676218837.0RepeatNote=TPR 6
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212677_710218837.0RepeatNote=TPR 7
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212712_744218837.0RepeatNote=TPR 8
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212746_778218837.0RepeatNote=TPR 9
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212779_812218837.0RepeatNote=TPR 10
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212222_241218837.0TransmembraneHelical
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212313_333218837.0TransmembraneHelical
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212400_420218837.0TransmembraneHelical
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212423_443218837.0TransmembraneHelical
HgeneTMTC2chr12:83251359chr12:69644909ENST00000321196+212450_470218837.0TransmembraneHelical


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Fusion Gene Sequence for TMTC2-CPSF6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92510_92510_1_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000321196_CPSF6_chr12_69644909_ENST00000266679_length(transcript)=3499nt_BP=1361nt
GTCACGCAGGCGCGGGGGGCCGCGTCGAGAACCCCACGCGGGAGCTTCTGGAGTCTCCAGCCACCGCTTCTCACTTCACTGGAGAAGGGA
GCTGGGGCTGGGGCTGGGGCTGGGGCTGGGAGGGAGCTAATAAACATTGAATGTGCAGCAGCTGCCTTGGCGGCCGGAGTCCGCCCGAGC
GACACCGGAGCAGTGCGCCCGGGAGGCGGCGAGGGGAGGCGGTTCGCCTTGTCCCTCCCACCCGCGCCTCTTTCTCTCTCTTCCTCCAGC
TGGTCCCAGAGCCCGGCTTGGTCCGGTCCCTCTGCCCCCATCCCGCACCCTTCCACCTCCTCCGAGTCCCACTCCTCACCTAGGACGCCC
CAAACTGCCATGGGTTAGGGTGGGGATCGCGACCCGCGCGAAAGACCAGCCCTGCGCTTCCGCCGGGGGACGCGGAGCCCAAACGCCGCT
CACCGCTTGCGGGCGCCGGGCATGGGGAGTGTGGTGTGAGCCCGCACCCGGGGAGGACGCAGGAGCTGCGGAGACGGGCGCGAGGAGGAG
GAGAGGAGTCGTGGATTGGAAGGACCCGAGGGAGGGAGGGTGGGGAAGCGAGGGAAAAGTGAAGCTGGGAGGAGAAGGCGGCGGAAGGTG
GAGATTGATGCTTCTGTTTTTTGTTGCCGCTGCTGCCCTCGCGCTGGGAGCCGAGCCGGAGGGAAGGCGGTGGAGAGATGATTGCAGAGT
TGGTGAGCAGCGCTCTGGGGCTCGCCTTGTATCTCAACACCCTGAGTGCGGATTTCTGCTATGATGACAGCCGTGCTATCAAGACTAATC
AGGACCTTCTCCCAGAAACTCCATGGACGCACATTTTCTACAATGATTTTTGGGGGACTCTTCTAACCCACAGTGGCAGCCACAAGTCCT
ACCGGCCACTCTGCACTCTTTCTTTTCGCCTGAACCATGCCATTGGAGGGTTGAATCCCTGGAGCTACCATCTTGTCAATGTCCTGTTGC
ATGCAGCAGTCACTGGTCTCTTCACAAGCTTCTCCAAGATCCTCCTTGGTGATGGATACTGGACATTCATGGCTGGCTTGATGTTTGCTT
CTCACCCCATTCACACGGAGGCAGTGGCAGGAATCGTGGGACGAGCCGATGTCGGGGCCAGTCTCTTCTTTCTCCTCTCCTTGCTCTGCT
ACATTAAACACTGTTCTACAAGAGGCTACTCAGCCAGAACCTGGGGCTGGTTCCTGGGGTCAGGACTGTGCGCAGGATGCAGCATGTTGT
GGAAGGAACAAGGAGTGACTGTTCTCGCAGTTTCAGCAGTTTATGATGTCTTTGTCTTTCACAGGCTGAAAATAAAACAGATATTACCTA
CCATTTACAAAGAAGCTGAATATGGTGGGCATGATCAGATAGATTTGTATGACGATGTCATATCTCCATCTGCAAATAATGGAGATGCCC
CAGAAGACCGAGATTACATGGATACTCTCCCACCAACTGTTGGTGATGATGTGGGTAAAGGAGCAGCACCAAATGTTGTCTATACATATA
CTGGAAAGAGAATTGCATTATATATTGGAAATCTAACATGGTGGACAACAGATGAAGACTTAACTGAAGCAGTTCATTCTTTGGGAGTAA
ATGATATTTTGGAGATAAAATTTTTTGAAAATCGGGCAAATGGCCAGTCAAAGGGGTTTGCCCTTGTTGGTGTTGGATCTGAAGCATCTT
CAAAAAAGTTAATGGATCTGTTACCTAAAAGAGAACTTCATGGTCAGAATCCTGTTGTAACTCCATGCAATAAACAGTTCCTGAGTCAAT
TTGAAATGCAGTCCAGGAAAACTACACAATCAGGACAAATGTCTGGGGAAGGTAAAGCTGGTCCTCCAGGAGGCAGTTCCCGTGCAGCAT
TTCCACAAGGTGGTAGAGGACGGGGCCGTTTTCCAGGGGCTGTTCCTGGTGGGGACAGATTTCCTGGGCCAGCAGGACCAGGAGGGCCAC
CCCCACCTTTTCCAGGAAATTTGATCAAGCATCTTGTTAAAGGAACTCGGCCTTTGTTCCTGGAAACTAGGATTCCATGGCATATGGGGC
ACAGCATAGAGGAAATACCCATTTTTGGCCTAAAAGCTGGACAGACTCCACCACGTCCACCCTTAGGTCCTCCAGGCCCACCTGGTCCAC
CAGGTCCTCCACCTCCTGGTCAGGTTCTGCCTCCTCCTCTAGCTGGGCCTCCTAATCGAGGAGATCGCCCTCCACCACCAGTTCTTTTTC
CTGGACAACCTTTTGGGCAGCCTCCATTGGGTCCACTTCCTCCTGGCCCTCCACCTCCAGTTCCAGGCTACGGCCCCCCTCCTGGCCCAC
CACCTCCACAACAGGGACCACCTCCACCTCCAGGCCCCTTTCCACCTCGTCCACCCGGTCCACTTGGGCCACCCCTTACACTAGCTCCTC
CTCCGCATCTTCCTGGACCACCTCCAGGTGCCCCACCGCCAGCTCCGCATGTGAACCCAGCTTTCTTTCCTCCACCAACTAACAGTGGCA
TGCCTACATCAGATAGCCGAGGTCCACCACCAACAGATCCATATGGGCGACCTCCACCATATGATAGGGGTGACTATGGCCCCCCTGGAA
GGGAAATGGATACTGCAAGAACGCCATTGAGTGAAGCTGAATTTGAAGAAATCATGAATAGAAATAGGGCAATCTCAAGCAGTGCTATTT
CGAGAGCTGTGTCTGATGCCAGTGCTGGTGATTATGGGAGTGCTATTGAGACACTGGTAACTGCAATTTCTTTAATTAAACAATCCAAAG
TATCTGCTGATGATCGTTGCAAAGTTCTTATTAGTTCTTTGCAAGATTGCCTTCATGGAATTGAGTCCAAGTCTTATGGTTCTGGATCAA
GACGTGAACGATCAAGAGAGAGGGACCATAGTAGATCACGAGAAAAGAGTCGACGTCATAAATCCCGTAGTAGAGACCGTCATGACGATT
ATTACAGAGAGAGAAGCAGAGAACGAGAGAGGCACCGGGATCGTGACCGAGACCGTGACCGAGAGCGTGACCGAGAGCGCGAATATCGTC
ATCGTTAGAAGCTGAAGGAAGAGGATCACCTTCCAAGACAAAACAGTCTTCATGGGGGAAAAATGACGCTTGTCCAGCAGTTTGCTTCTT
GTGATTGAACTGAACCTGTAAGGATTCATGGATAAAATGAACAGGAATAGATCTGAATAAAGCAAATCTGCATAAATGGTAACCAGTAGC
TCTACTTTTATTTTTTATGTTGCTTAACTGTTTTATTTGAAGGAAACCTGTGTGATTTAAAAAGTTATAGCTTTTGCAACTTTATTACTG
GTTATATACATTTGGCCATTATGATGTGCAAGCAATTGGAAAAAAAGTCAAGTAAATGCTTGTTTTTGTAGTAGTTTGTTCTTGTTAAAA

>92510_92510_1_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000321196_CPSF6_chr12_69644909_ENST00000266679_length(amino acids)=805AA_BP=237
MLPLLPSRWEPSRREGGGEMIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTL
SFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCST
RGYSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYM
DTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDL
LPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPGN
LIKHLVKGTRPLFLETRIPWHMGHSIEEIPIFGLKAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQ
PPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSR
GPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRC

--------------------------------------------------------------
>92510_92510_2_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000321196_CPSF6_chr12_69644909_ENST00000435070_length(transcript)=7807nt_BP=1361nt
GTCACGCAGGCGCGGGGGGCCGCGTCGAGAACCCCACGCGGGAGCTTCTGGAGTCTCCAGCCACCGCTTCTCACTTCACTGGAGAAGGGA
GCTGGGGCTGGGGCTGGGGCTGGGGCTGGGAGGGAGCTAATAAACATTGAATGTGCAGCAGCTGCCTTGGCGGCCGGAGTCCGCCCGAGC
GACACCGGAGCAGTGCGCCCGGGAGGCGGCGAGGGGAGGCGGTTCGCCTTGTCCCTCCCACCCGCGCCTCTTTCTCTCTCTTCCTCCAGC
TGGTCCCAGAGCCCGGCTTGGTCCGGTCCCTCTGCCCCCATCCCGCACCCTTCCACCTCCTCCGAGTCCCACTCCTCACCTAGGACGCCC
CAAACTGCCATGGGTTAGGGTGGGGATCGCGACCCGCGCGAAAGACCAGCCCTGCGCTTCCGCCGGGGGACGCGGAGCCCAAACGCCGCT
CACCGCTTGCGGGCGCCGGGCATGGGGAGTGTGGTGTGAGCCCGCACCCGGGGAGGACGCAGGAGCTGCGGAGACGGGCGCGAGGAGGAG
GAGAGGAGTCGTGGATTGGAAGGACCCGAGGGAGGGAGGGTGGGGAAGCGAGGGAAAAGTGAAGCTGGGAGGAGAAGGCGGCGGAAGGTG
GAGATTGATGCTTCTGTTTTTTGTTGCCGCTGCTGCCCTCGCGCTGGGAGCCGAGCCGGAGGGAAGGCGGTGGAGAGATGATTGCAGAGT
TGGTGAGCAGCGCTCTGGGGCTCGCCTTGTATCTCAACACCCTGAGTGCGGATTTCTGCTATGATGACAGCCGTGCTATCAAGACTAATC
AGGACCTTCTCCCAGAAACTCCATGGACGCACATTTTCTACAATGATTTTTGGGGGACTCTTCTAACCCACAGTGGCAGCCACAAGTCCT
ACCGGCCACTCTGCACTCTTTCTTTTCGCCTGAACCATGCCATTGGAGGGTTGAATCCCTGGAGCTACCATCTTGTCAATGTCCTGTTGC
ATGCAGCAGTCACTGGTCTCTTCACAAGCTTCTCCAAGATCCTCCTTGGTGATGGATACTGGACATTCATGGCTGGCTTGATGTTTGCTT
CTCACCCCATTCACACGGAGGCAGTGGCAGGAATCGTGGGACGAGCCGATGTCGGGGCCAGTCTCTTCTTTCTCCTCTCCTTGCTCTGCT
ACATTAAACACTGTTCTACAAGAGGCTACTCAGCCAGAACCTGGGGCTGGTTCCTGGGGTCAGGACTGTGCGCAGGATGCAGCATGTTGT
GGAAGGAACAAGGAGTGACTGTTCTCGCAGTTTCAGCAGTTTATGATGTCTTTGTCTTTCACAGGCTGAAAATAAAACAGATATTACCTA
CCATTTACAAAGAAGCTGAATATGGTGGGCATGATCAGATAGATTTGTATGACGATGTCATATCTCCATCTGCAAATAATGGAGATGCCC
CAGAAGACCGAGATTACATGGATACTCTCCCACCAACTGTTGGTGATGATGTGGGTAAAGGAGCAGCACCAAATGTTGTCTATACATATA
CTGGAAAGAGAATTGCATTATATATTGGAAATCTAACATGGTGGACAACAGATGAAGACTTAACTGAAGCAGTTCATTCTTTGGGAGTAA
ATGATATTTTGGAGATAAAATTTTTTGAAAATCGGGCAAATGGCCAGTCAAAGGGGTTTGCCCTTGTTGGTGTTGGATCTGAAGCATCTT
CAAAAAAGTTAATGGATCTGTTACCTAAAAGAGAACTTCATGGTCAGAATCCTGTTGTAACTCCATGCAATAAACAGTTCCTGAGTCAAT
TTGAAATGCAGTCCAGGAAAACTACACAATCAGGACAAATGTCTGGGGAAGGTAAAGCTGGTCCTCCAGGAGGCAGTTCCCGTGCAGCAT
TTCCACAAGGTGGTAGAGGACGGGGCCGTTTTCCAGGGGCTGTTCCTGGTGGGGACAGATTTCCTGGGCCAGCAGGACCAGGAGGGCCAC
CCCCACCTTTTCCAGCTGGACAGACTCCACCACGTCCACCCTTAGGTCCTCCAGGCCCACCTGGTCCACCAGGTCCTCCACCTCCTGGTC
AGGTTCTGCCTCCTCCTCTAGCTGGGCCTCCTAATCGAGGAGATCGCCCTCCACCACCAGTTCTTTTTCCTGGACAACCTTTTGGGCAGC
CTCCATTGGGTCCACTTCCTCCTGGCCCTCCACCTCCAGTTCCAGGCTACGGCCCCCCTCCTGGCCCACCACCTCCACAACAGGGACCAC
CTCCACCTCCAGGCCCCTTTCCACCTCGTCCACCCGGTCCACTTGGGCCACCCCTTACACTAGCTCCTCCTCCGCATCTTCCTGGACCAC
CTCCAGGTGCCCCACCGCCAGCTCCGCATGTGAACCCAGCTTTCTTTCCTCCACCAACTAACAGTGGCATGCCTACATCAGATAGCCGAG
GTCCACCACCAACAGATCCATATGGGCGACCTCCACCATATGATAGGGGTGACTATGGCCCCCCTGGAAGGGAAATGGATACTGCAAGAA
CGCCATTGAGTGAAGCTGAATTTGAAGAAATCATGAATAGAAATAGGGCAATCTCAAGCAGTGCTATTTCGAGAGCTGTGTCTGATGCCA
GTGCTGGTGATTATGGGAGTGCTATTGAGACACTGGTAACTGCAATTTCTTTAATTAAACAATCCAAAGTATCTGCTGATGATCGTTGCA
AAGTTCTTATTAGTTCTTTGCAAGATTGCCTTCATGGAATTGAGTCCAAGTCTTATGGTTCTGGATCAAGACGTGAACGATCAAGAGAGA
GGGACCATAGTAGATCACGAGAAAAGAGTCGACGTCATAAATCCCGTAGTAGAGACCGTCATGACGATTATTACAGAGAGAGAAGCAGAG
AACGAGAGAGGCACCGGGATCGTGACCGAGACCGTGACCGAGAGCGTGACCGAGAGCGCGAATATCGTCATCGTTAGAAGCTGAAGGAAG
AGGATCACCTTCCAAGACAAAACAGTCTTCATGGGGGAAAAATGACGCTTGTCCAGCAGTTTGCTTCTTGTGATTGAACTGAACCTGTAA
GGATTCATGGATAAAATGAACAGGAATAGATCTGAATAAAGCAAATCTGCATAAATGGTAACCAGTAGCTCTACTTTTATTTTTTATGTT
GCTTAACTGTTTTATTTGAAGGAAACCTGTGTGATTTAAAAAGTTATAGCTTTTGCAACTTTATTACTGGTTATATACATTTGGCCATTA
TGATGTGCAAGCAATTGGAAAAAAAGTCAAGTAAATGCTTGTTTTTGTAGTAGTTTGTTCTTGTTAAAAATGTTTATATGATAATGTCTG
TAAACAGCATCACTTTGATTACAATAGATGTAGTGTTGTAATAAACTGTTTAATGGGGCTGATGTGTAAAGCTGTTCAAGTTATTTGATG
TTTACACCTCAGGGAAAGTCTTGTGTTCAGCAATATCTAAAGATAATGTTACTATGACAACATTTTTACTGTCCTTTAAAGCATTGCAAT
AGCGTTTTTGGATATGCCTCAATCTAATCTTGCGTTCAGTGAATTAAACATAGTAATTAAGTGTCTTTTGCCCTTGATTTTGATATTAGA
ATAGGTGATTACATGGATATTTAATATTTCTATATTCTGCTTTTCTAGCTGTTTTTACCTAGTTAGCTTGTGACTTTGCTGAATGGTATG
TAAACTTGTAAAAATAGAGATTTGACAGACATAGCAATCTAGTCAATGTGTAAGGGGTCAAAAAAACAGAGGTTTTAACACATAAGTAAA
AACCCGTACATATTTGATGTGTAATGCAGGTTAATTACAACACAGATGTACCGAAACACTTAATTGTGAACCGCTAACATTGAAGAAATT
TTGACAATTCCGATTTGATGCTGCAATTACTTGCTGTTTTTATTGATCTTATGGTTTATTTCTTAAGCCATAGTCAGTGTAAATACAGCC
CTGCAGCAGGTAAATGTGAGTAAAGAGAGCCTTATATTTTCCAATTGGTATAAATTTTTGAAGGATGTGATGTTCATTAACATTCGGTTG
TATTCCCCAGTATTTGTAATGGGAAATTACAGATAAACCGTGTCTGCACAGTTTAAGGAATACTATGTATATTCATGCACCGTATTGATT
CATGCTATAGTTACTTAATCAAAGATTTTTTTCAAACCTGCCTTACATATAGGCCCACTTTAAAAGCACCTGACTAGCATGTGTTCTTGA
TTGCAAAATTGGCAGAGGCAGGGTGTCAACTTGATTAGGTGTTTTTATGGGAATGTAATTTGAAATCACTACTTCAGAAATTTGACTTAA
AATTCTTGAGCACGTTAATATGTTTTTAAGATCTGATTATCTTTGAGAGATCTTCTGTTAATACACATTGGTTGTTAAAGAGTACCCAAA
TTCTAGGACAATGCTTAAAGTGTTAAAATACCCTAGATACTGTGTTATGTGCAACTGTAGAAACCCTCCAGAAATTTCCACTGCTGTTCT
TCACTTTCATCTTGTCTGCTATCAAACCACTTCTGACAAAATTAGCTGTTTTGAATTACCCATATCACTGCCAGTTTTATTTTAAAATAT
TTTGTGTTTGAAGTATCTGTGCATGGGATCGTTGATGTTTATCAGAACTGTTCACTTTCAGAAATGATTTTTTAAAGCATTTTGTTGAAA
ATGCGGTTGCTTTTTTAACATTATTTTAGAGTTGTATCAAAATTTTCCTGTTTTCTGTATATTGTTGTGTCATTTCTTGGCTTTTTAATA
TTTTGACTACAATGCCCTAATGCGAAGAAGTATGGACATATAAATATTACAAGAGAAATTAGTTAATAGTAAAGGGTTAAAAGGTAAGTA
AAATGTCCATGAAAATAAAATTTTCTTTGAACAGTTTAAAAATGGAATCACAAAAATCTAACTGCACTTGAAATGAAACTGGAAATTTTA
TACTAATTAAATCCTTTATTTACCTTTTCATATTTTATCAATGGAACCTTTTAATTGCTCCTTCTATATCACTCTTCTCCTTGCTTGGCT
GATCTCATTACATGACTTTCGTTACAGACAGTGTGAGTGTACTAGATTTGTTTGCTGCTAATCCGTTATTTTAAGTGTTGTCAGAAGGAA
ATAACTTCTTGGTTTGACCAAGTAATTTTGCAAAGTCCTTCTCTACCTGATAACACGTGAATGTATAGCAGTAAAGGTGAAAATTGCAGG
CCTTGTTTTGTTCTTCATACCCCCTTCAGTTGTTTATGGGTTAATGTTATTTGAAAACTCTTCCTTTTTTTAATGTGTAAAAACAATCCA
AAGAGATAAATCCTTGCATAGACACCAAAAACAGTGTCTCAGAGACCTTTTCATTTTTTCCTTAGTTAATAACTGTAGTGGATGTGAAAA
CAAACGAGTTGAATTTTAAAACATAGCATTTATTAGTGCTATACAGTCACATTCCTTTCAGCCAGTAGTAAAGTTAAACAGATGAGTGAT
ACAGTACCTGAATGGTACTGCTTCTGAGGCAACACTTTGGATTGAAAGTGCTGCTTTTGGTTAAAGGAACTATGTTGTGGAAAGCATATT
CCAGTGTAAATTTGCAGATGTGTGTTTTTTTTTTTTGTCACTTTTCATAAGGTTTGGAGTAAGTTGCAGTGGCTTTTGATCATAGTTTAG
CCCATTTAATGGTCCTTTTACCTAGAATGTTCTTAAGCAGTTAATGACAATTTGGAATACACAGATAACTTGTAGCTTAAGATACTATTT
TCATTTAATTCTCCTGTGGAGAATATTGCTTTATTTTTTACTAGTTTCAGGTCAGTTATTAAAATAAACATGGAGGTTTTAATGAATGTT
GTATAATATTTTATAGTGAAGGAAAATTGTGGAAAGGGCAAAGACTTTCTCTTTCCCTTATGTATTTAACTGTGCCAATCTAAATACATA
CTGTTTTATACAATGAGATGCATTACAAGACTTTTCTGTTGGAGTGCTCTCGACATTTTGGTTTTCATACCTGAATGATCATTGCATTTT
CTGTATTTTCTAAAATGGCTCCAATTTTGTGTTTTAAGCTTCAGCTTAAGAGGAAGTTTATGTTCTAATTCTTGACTGAGAATACAGTAT
TGAGATTCTCTGTTTTACAGATAACAACTGGTTTTTATTACTCATTAAGTTCATTTGCATCCCGTAGCCCTCTGTAAATGTTTCCCCTAG
TTGTATGTACGTAAATGCACGCTTATCCAGTGTATATTAGACATTTTTGTGCTAAAATATATTAAGTGGGATTTTTGTAGCAAAGCATTC
TATTTTTCTGTTCTTACAGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGCGTTTTTTTAACCTTAACTTCAGTTTAAACACTGGTGTATT
TATTTTTTTAAGCAACTTGACTCTTAGAAGCCTTAGACTGATTTTTTCAATAAATATTCAACCAAAAATTATAAATTTATTAAGATGTGG
CCTTACATATGGCATTCCTTGTGTTCGTAATGTGAGATTTTTGATTTAGATAAATCAAGATTCAGGATTAAAGTTTCATTGTAAGTTGAA
ATAGAAAATGTATTAAAATGTCTAGGCTTCTGGGAGGAAGTTCTTATACTCTTCTTTCTTGGCATTAGAAAGAAGCAATATGAATTTTTG
TGAATATTCTAAATATTCAGGCAACACTGTTCAGATTGATTTAGGTTTGTCTTAACCAATGTTCTTTTTTTAGAATTTCAGGTTGTGGCA
TTCACTGAGTATGCAGCTACTATGGTTTTTGTATGGGACGTATAAATACTTGATTATATACGACAGATTTTAATGTCTTTAAAGACTTCC
TGCTGTATTAACATATTGTAATGGAGTCTTTTAAATACTAGGTTGAATTTAATTGAAGTCACACACATCTTGAAGTGGTAACTGCATAGT
AAATACTACCAAGAGTTTTTTTCACGTGGGAGTATCCTAAAACTCTGCCATGGGTGTAAATGTTTTACATTAATTTCATAATTGGACAGA
CCCTGCATTTAGCGAAAACATTTTGTTTTGAAAGTGTGTTCTTTTTGTCGCACTGTTACTGCGTAACACTTCTCAACATTCTGTAAGTTA
AATTATTTTAAAATAACTATGGTGAATTCATGTTTATTTTTTTACTTTGAAAATTGTAGTACTCAGGTGGTATTTAATGGGAAAGGATCC
TTTGGGTATAAATCATAATGTATTTTAAGGAATGCATCTATAACATTGATAACTTTAGCCTTAAAAAAAAGGTCTATTATTCCTTCCTCT
GCATCCCATGGTATATTAGCAAAGTAGTTTACAGCCCTGTACAGCCTTACAAAGTTGTTTTACAATTTTTAATGGAAAGCCCTTAACAAC
AACAACAAAAAATTGTATCATTTTACCAATATCCACGAATTACTGATCACAGTTTGTAAATAATTTGTTTAATATCAGAAGGCCAAAGAA
AGTCTTAAAATTTTAGCTATTGACTCTATGGTGACTTCACAATAAGATTTCTGTGCAAAAAGGTAAGGTGATAATTGATCTAATAGACTT
TTTTTTTTTTTTTTTTGCTGTCCATGAGAATTAGACTTCATATTAGCTTCAATTAAAAAGCTCATTCCATTTTATTAAAATGTTTGTAAT
TGCAATTTTGTGTTTAATGTTTACTTTGTCTTTCCTTTCTTTAGCATTTAGGTGACTGTTCGGCAGTTTGATATATGGCCATTGTCGGCC

>92510_92510_2_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000321196_CPSF6_chr12_69644909_ENST00000435070_length(amino acids)=768AA_BP=237
MLPLLPSRWEPSRREGGGEMIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTL
SFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCST
RGYSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYM
DTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDL
LPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPAG
QTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPF
PPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAE
FEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYGSGSRRERSRERDHSRSR

--------------------------------------------------------------
>92510_92510_3_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000321196_CPSF6_chr12_69644909_ENST00000456847_length(transcript)=3169nt_BP=1361nt
GTCACGCAGGCGCGGGGGGCCGCGTCGAGAACCCCACGCGGGAGCTTCTGGAGTCTCCAGCCACCGCTTCTCACTTCACTGGAGAAGGGA
GCTGGGGCTGGGGCTGGGGCTGGGGCTGGGAGGGAGCTAATAAACATTGAATGTGCAGCAGCTGCCTTGGCGGCCGGAGTCCGCCCGAGC
GACACCGGAGCAGTGCGCCCGGGAGGCGGCGAGGGGAGGCGGTTCGCCTTGTCCCTCCCACCCGCGCCTCTTTCTCTCTCTTCCTCCAGC
TGGTCCCAGAGCCCGGCTTGGTCCGGTCCCTCTGCCCCCATCCCGCACCCTTCCACCTCCTCCGAGTCCCACTCCTCACCTAGGACGCCC
CAAACTGCCATGGGTTAGGGTGGGGATCGCGACCCGCGCGAAAGACCAGCCCTGCGCTTCCGCCGGGGGACGCGGAGCCCAAACGCCGCT
CACCGCTTGCGGGCGCCGGGCATGGGGAGTGTGGTGTGAGCCCGCACCCGGGGAGGACGCAGGAGCTGCGGAGACGGGCGCGAGGAGGAG
GAGAGGAGTCGTGGATTGGAAGGACCCGAGGGAGGGAGGGTGGGGAAGCGAGGGAAAAGTGAAGCTGGGAGGAGAAGGCGGCGGAAGGTG
GAGATTGATGCTTCTGTTTTTTGTTGCCGCTGCTGCCCTCGCGCTGGGAGCCGAGCCGGAGGGAAGGCGGTGGAGAGATGATTGCAGAGT
TGGTGAGCAGCGCTCTGGGGCTCGCCTTGTATCTCAACACCCTGAGTGCGGATTTCTGCTATGATGACAGCCGTGCTATCAAGACTAATC
AGGACCTTCTCCCAGAAACTCCATGGACGCACATTTTCTACAATGATTTTTGGGGGACTCTTCTAACCCACAGTGGCAGCCACAAGTCCT
ACCGGCCACTCTGCACTCTTTCTTTTCGCCTGAACCATGCCATTGGAGGGTTGAATCCCTGGAGCTACCATCTTGTCAATGTCCTGTTGC
ATGCAGCAGTCACTGGTCTCTTCACAAGCTTCTCCAAGATCCTCCTTGGTGATGGATACTGGACATTCATGGCTGGCTTGATGTTTGCTT
CTCACCCCATTCACACGGAGGCAGTGGCAGGAATCGTGGGACGAGCCGATGTCGGGGCCAGTCTCTTCTTTCTCCTCTCCTTGCTCTGCT
ACATTAAACACTGTTCTACAAGAGGCTACTCAGCCAGAACCTGGGGCTGGTTCCTGGGGTCAGGACTGTGCGCAGGATGCAGCATGTTGT
GGAAGGAACAAGGAGTGACTGTTCTCGCAGTTTCAGCAGTTTATGATGTCTTTGTCTTTCACAGGCTGAAAATAAAACAGATATTACCTA
CCATTTACAAAGAAGCTGAATATGGTGGGCATGATCAGATAGATTTGTATGACGATGTCATATCTCCATCTGCAAATAATGGAGATGCCC
CAGAAGACCGAGATTACATGGATACTCTCCCACCAACTGTTGGTGATGATGTGGGTAAAGGAGCAGCACCAAATGTTGTCTATACATATA
CTGGAAAGAGAATTGCATTATATATTGGAAATCTAACATGGTGGACAACAGATGAAGACTTAACTGAAGCAGTTCATTCTTTGGGAGTAA
ATGATATTTTGGAGATAAAATTTTTTGAAAATCGGGCAAATGGCCAGTCAAAGGGGTTTGCCCTTGTTGGTGTTGGATCTGAAGCATCTT
CAAAAAAGTTAATGGATCTGTTACCTAAAAGAGAACTTCATGGTCAGAATCCTGTTGTAACTCCATGCAATAAACAGTTCCTGAGTCAAT
TTGAAATGCAGTCCAGGAAAACTACACAATCAGGACAAATGTCTGGGGAAGGTAAAGCTGGTCCTCCAGGAGCTGGGCCTCCTAATCGAG
GAGATCGCCCTCCACCACCAGTTCTTTTTCCTGGACAACCTTTTGGGCAGCCTCCATTGGGTCCACTTCCTCCTGGCCCTCCACCTCCAG
TTCCAGGCTACGGCCCCCCTCCTGGCCCACCACCTCCACAACAGGGACCACCTCCACCTCCAGGCCCCTTTCCACCTCGTCCACCCGGTC
CACTTGGGCCACCCCTTACACTAGCTCCTCCTCCGCATCTTCCTGGACCACCTCCAGGTGCCCCACCGCCAGCTCCGCATGTGAACCCAG
CTTTCTTTCCTCCACCAACTAACAGTGGCATGCCTACATCAGATAGCCGAGGTCCACCACCAACAGATCCATATGGGCGACCTCCACCAT
ATGATAGGGGTGACTATGGCCCCCCTGGAAGGGAAATGGATACTGCAAGAACGCCATTGAGTGAAGCTGAATTTGAAGAAATCATGAATA
GAAATAGGGCAATCTCAAGCAGTGCTATTTCGAGAGCTGTGTCTGATGCCAGTGCTGGTGATTATGGGAGTGCTATTGAGACACTGGTAA
CTGCAATTTCTTTAATTAAACAATCCAAAGTATCTGCTGATGATCGTTGCAAAGTTCTTATTAGTTCTTTGCAAGATTGCCTTCATGGAA
TTGAGTCCAAGTCTTATGGTTCTGGATCAAGACGTGAACGATCAAGAGAGAGGGACCATAGTAGATCACGAGAAAAGAGTCGACGTCATA
AATCCCGTAGTAGAGACCGTCATGACGATTATTACAGAGAGAGAAGCAGAGAACGAGAGAGGCACCGGGATCGTGACCGAGACCGTGACC
GAGAGCGTGACCGAGAGCGCGAATATCGTCATCGTTAGAAGCTGAAGGAAGAGGATCACCTTCCAAGACAAAACAGTCTTCATGGGGGAA
AAATGACGCTTGTCCAGCAGTTTGCTTCTTGTGATTGAACTGAACCTGTAAGGATTCATGGATAAAATGAACAGGAATAGATCTGAATAA
AGCAAATCTGCATAAATGGTAACCAGTAGCTCTACTTTTATTTTTTATGTTGCTTAACTGTTTTATTTGAAGGAAACCTGTGTGATTTAA
AAAGTTATAGCTTTTGCAACTTTATTACTGGTTATATACATTTGGCCATTATGATGTGCAAGCAATTGGAAAAAAAGTCAAGTAAATGCT
TGTTTTTGTAGTAGTTTGTTCTTGTTAAAAATGTTTATATGATAATGTCTGTAAACAGCATCACTTTGATTACAATAGATGTAGTGTTGT

>92510_92510_3_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000321196_CPSF6_chr12_69644909_ENST00000456847_length(amino acids)=695AA_BP=237
MLPLLPSRWEPSRREGGGEMIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTL
SFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCST
RGYSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYM
DTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDL
LPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPP
PGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYG
PPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYG

--------------------------------------------------------------
>92510_92510_4_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000548305_CPSF6_chr12_69644909_ENST00000266679_length(transcript)=3378nt_BP=1240nt
GGGAGCTAATAAACATTGAATGTGCAGCAGCTGCCTTGGCGGCCGGAGTCCGCCCGAGCGACACCGGAGCAGTGCGCCCGGGAGGCGGCG
AGGGGAGGCGGTTCGCCTTGTCCCTCCCACCCGCGCCTCTTTCTCTCTCTTCCTCCAGCTGGTCCCAGAGCCCGGCTTGGTCCGGTCCCT
CTGCCCCCATCCCGCACCCTTCCACCTCCTCCGAGTCCCACTCCTCACCTAGGACGCCCCAAACTGCCATGGGTTAGGGTGGGGATCGCG
ACCCGCGCGAAAGACCAGCCCTGCGCTTCCGCCGGGGGACGCGGAGCCCAAACGCCGCTCACCGCTTGCGGGCGCCGGGCATGGGGAGTG
TGGTGTGAGCCCGCACCCGGGGAGGACGCAGGAGCTGCGGAGACGGGCGCGAGGAGGAGGAGAGGAGTCGTGGATTGGAAGGACCCGAGG
GAGGGAGGGTGGGGAAGCGAGGGAAAAGTGAAGCTGGGAGGAGAAGGCGGCGGAAGGTGGAGATTGATGCTTCTGTTTTTTGTTGCCGCT
GCTGCCCTCGCGCTGGGAGCCGAGCCGGAGGGAAGGCGGTGGAGAGATGATTGCAGAGTTGGTGAGCAGCGCTCTGGGGCTCGCCTTGTA
TCTCAACACCCTGAGTGCGGATTTCTGCTATGATGACAGCCGTGCTATCAAGACTAATCAGGACCTTCTCCCAGAAACTCCATGGACGCA
CATTTTCTACAATGATTTTTGGGGGACTCTTCTAACCCACAGTGGCAGCCACAAGTCCTACCGGCCACTCTGCACTCTTTCTTTTCGCCT
GAACCATGCCATTGGAGGGTTGAATCCCTGGAGCTACCATCTTGTCAATGTCCTGTTGCATGCAGCAGTCACTGGTCTCTTCACAAGCTT
CTCCAAGATCCTCCTTGGTGATGGATACTGGACATTCATGGCTGGCTTGATGTTTGCTTCTCACCCCATTCACACGGAGGCAGTGGCAGG
AATCGTGGGACGAGCCGATGTCGGGGCCAGTCTCTTCTTTCTCCTCTCCTTGCTCTGCTACATTAAACACTGTTCTACAAGAGGCTACTC
AGCCAGAACCTGGGGCTGGTTCCTGGGGTCAGGACTGTGCGCAGGATGCAGCATGTTGTGGAAGGAACAAGGAGTGACTGTTCTCGCAGT
TTCAGCAGTTTATGATGTCTTTGTCTTTCACAGGCTGAAAATAAAACAGATATTACCTACCATTTACAAAGAAGCTGAATATGGTGGGCA
TGATCAGATAGATTTGTATGACGATGTCATATCTCCATCTGCAAATAATGGAGATGCCCCAGAAGACCGAGATTACATGGATACTCTCCC
ACCAACTGTTGGTGATGATGTGGGTAAAGGAGCAGCACCAAATGTTGTCTATACATATACTGGAAAGAGAATTGCATTATATATTGGAAA
TCTAACATGGTGGACAACAGATGAAGACTTAACTGAAGCAGTTCATTCTTTGGGAGTAAATGATATTTTGGAGATAAAATTTTTTGAAAA
TCGGGCAAATGGCCAGTCAAAGGGGTTTGCCCTTGTTGGTGTTGGATCTGAAGCATCTTCAAAAAAGTTAATGGATCTGTTACCTAAAAG
AGAACTTCATGGTCAGAATCCTGTTGTAACTCCATGCAATAAACAGTTCCTGAGTCAATTTGAAATGCAGTCCAGGAAAACTACACAATC
AGGACAAATGTCTGGGGAAGGTAAAGCTGGTCCTCCAGGAGGCAGTTCCCGTGCAGCATTTCCACAAGGTGGTAGAGGACGGGGCCGTTT
TCCAGGGGCTGTTCCTGGTGGGGACAGATTTCCTGGGCCAGCAGGACCAGGAGGGCCACCCCCACCTTTTCCAGGAAATTTGATCAAGCA
TCTTGTTAAAGGAACTCGGCCTTTGTTCCTGGAAACTAGGATTCCATGGCATATGGGGCACAGCATAGAGGAAATACCCATTTTTGGCCT
AAAAGCTGGACAGACTCCACCACGTCCACCCTTAGGTCCTCCAGGCCCACCTGGTCCACCAGGTCCTCCACCTCCTGGTCAGGTTCTGCC
TCCTCCTCTAGCTGGGCCTCCTAATCGAGGAGATCGCCCTCCACCACCAGTTCTTTTTCCTGGACAACCTTTTGGGCAGCCTCCATTGGG
TCCACTTCCTCCTGGCCCTCCACCTCCAGTTCCAGGCTACGGCCCCCCTCCTGGCCCACCACCTCCACAACAGGGACCACCTCCACCTCC
AGGCCCCTTTCCACCTCGTCCACCCGGTCCACTTGGGCCACCCCTTACACTAGCTCCTCCTCCGCATCTTCCTGGACCACCTCCAGGTGC
CCCACCGCCAGCTCCGCATGTGAACCCAGCTTTCTTTCCTCCACCAACTAACAGTGGCATGCCTACATCAGATAGCCGAGGTCCACCACC
AACAGATCCATATGGGCGACCTCCACCATATGATAGGGGTGACTATGGCCCCCCTGGAAGGGAAATGGATACTGCAAGAACGCCATTGAG
TGAAGCTGAATTTGAAGAAATCATGAATAGAAATAGGGCAATCTCAAGCAGTGCTATTTCGAGAGCTGTGTCTGATGCCAGTGCTGGTGA
TTATGGGAGTGCTATTGAGACACTGGTAACTGCAATTTCTTTAATTAAACAATCCAAAGTATCTGCTGATGATCGTTGCAAAGTTCTTAT
TAGTTCTTTGCAAGATTGCCTTCATGGAATTGAGTCCAAGTCTTATGGTTCTGGATCAAGACGTGAACGATCAAGAGAGAGGGACCATAG
TAGATCACGAGAAAAGAGTCGACGTCATAAATCCCGTAGTAGAGACCGTCATGACGATTATTACAGAGAGAGAAGCAGAGAACGAGAGAG
GCACCGGGATCGTGACCGAGACCGTGACCGAGAGCGTGACCGAGAGCGCGAATATCGTCATCGTTAGAAGCTGAAGGAAGAGGATCACCT
TCCAAGACAAAACAGTCTTCATGGGGGAAAAATGACGCTTGTCCAGCAGTTTGCTTCTTGTGATTGAACTGAACCTGTAAGGATTCATGG
ATAAAATGAACAGGAATAGATCTGAATAAAGCAAATCTGCATAAATGGTAACCAGTAGCTCTACTTTTATTTTTTATGTTGCTTAACTGT
TTTATTTGAAGGAAACCTGTGTGATTTAAAAAGTTATAGCTTTTGCAACTTTATTACTGGTTATATACATTTGGCCATTATGATGTGCAA
GCAATTGGAAAAAAAGTCAAGTAAATGCTTGTTTTTGTAGTAGTTTGTTCTTGTTAAAAATGTTTATATGATAATGTCTGTAAACAGCAT

>92510_92510_4_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000548305_CPSF6_chr12_69644909_ENST00000266679_length(amino acids)=805AA_BP=237
MLPLLPSRWEPSRREGGGEMIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTL
SFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCST
RGYSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYM
DTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDL
LPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPGN
LIKHLVKGTRPLFLETRIPWHMGHSIEEIPIFGLKAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQ
PPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSR
GPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRC

--------------------------------------------------------------
>92510_92510_5_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000548305_CPSF6_chr12_69644909_ENST00000435070_length(transcript)=7686nt_BP=1240nt
GGGAGCTAATAAACATTGAATGTGCAGCAGCTGCCTTGGCGGCCGGAGTCCGCCCGAGCGACACCGGAGCAGTGCGCCCGGGAGGCGGCG
AGGGGAGGCGGTTCGCCTTGTCCCTCCCACCCGCGCCTCTTTCTCTCTCTTCCTCCAGCTGGTCCCAGAGCCCGGCTTGGTCCGGTCCCT
CTGCCCCCATCCCGCACCCTTCCACCTCCTCCGAGTCCCACTCCTCACCTAGGACGCCCCAAACTGCCATGGGTTAGGGTGGGGATCGCG
ACCCGCGCGAAAGACCAGCCCTGCGCTTCCGCCGGGGGACGCGGAGCCCAAACGCCGCTCACCGCTTGCGGGCGCCGGGCATGGGGAGTG
TGGTGTGAGCCCGCACCCGGGGAGGACGCAGGAGCTGCGGAGACGGGCGCGAGGAGGAGGAGAGGAGTCGTGGATTGGAAGGACCCGAGG
GAGGGAGGGTGGGGAAGCGAGGGAAAAGTGAAGCTGGGAGGAGAAGGCGGCGGAAGGTGGAGATTGATGCTTCTGTTTTTTGTTGCCGCT
GCTGCCCTCGCGCTGGGAGCCGAGCCGGAGGGAAGGCGGTGGAGAGATGATTGCAGAGTTGGTGAGCAGCGCTCTGGGGCTCGCCTTGTA
TCTCAACACCCTGAGTGCGGATTTCTGCTATGATGACAGCCGTGCTATCAAGACTAATCAGGACCTTCTCCCAGAAACTCCATGGACGCA
CATTTTCTACAATGATTTTTGGGGGACTCTTCTAACCCACAGTGGCAGCCACAAGTCCTACCGGCCACTCTGCACTCTTTCTTTTCGCCT
GAACCATGCCATTGGAGGGTTGAATCCCTGGAGCTACCATCTTGTCAATGTCCTGTTGCATGCAGCAGTCACTGGTCTCTTCACAAGCTT
CTCCAAGATCCTCCTTGGTGATGGATACTGGACATTCATGGCTGGCTTGATGTTTGCTTCTCACCCCATTCACACGGAGGCAGTGGCAGG
AATCGTGGGACGAGCCGATGTCGGGGCCAGTCTCTTCTTTCTCCTCTCCTTGCTCTGCTACATTAAACACTGTTCTACAAGAGGCTACTC
AGCCAGAACCTGGGGCTGGTTCCTGGGGTCAGGACTGTGCGCAGGATGCAGCATGTTGTGGAAGGAACAAGGAGTGACTGTTCTCGCAGT
TTCAGCAGTTTATGATGTCTTTGTCTTTCACAGGCTGAAAATAAAACAGATATTACCTACCATTTACAAAGAAGCTGAATATGGTGGGCA
TGATCAGATAGATTTGTATGACGATGTCATATCTCCATCTGCAAATAATGGAGATGCCCCAGAAGACCGAGATTACATGGATACTCTCCC
ACCAACTGTTGGTGATGATGTGGGTAAAGGAGCAGCACCAAATGTTGTCTATACATATACTGGAAAGAGAATTGCATTATATATTGGAAA
TCTAACATGGTGGACAACAGATGAAGACTTAACTGAAGCAGTTCATTCTTTGGGAGTAAATGATATTTTGGAGATAAAATTTTTTGAAAA
TCGGGCAAATGGCCAGTCAAAGGGGTTTGCCCTTGTTGGTGTTGGATCTGAAGCATCTTCAAAAAAGTTAATGGATCTGTTACCTAAAAG
AGAACTTCATGGTCAGAATCCTGTTGTAACTCCATGCAATAAACAGTTCCTGAGTCAATTTGAAATGCAGTCCAGGAAAACTACACAATC
AGGACAAATGTCTGGGGAAGGTAAAGCTGGTCCTCCAGGAGGCAGTTCCCGTGCAGCATTTCCACAAGGTGGTAGAGGACGGGGCCGTTT
TCCAGGGGCTGTTCCTGGTGGGGACAGATTTCCTGGGCCAGCAGGACCAGGAGGGCCACCCCCACCTTTTCCAGCTGGACAGACTCCACC
ACGTCCACCCTTAGGTCCTCCAGGCCCACCTGGTCCACCAGGTCCTCCACCTCCTGGTCAGGTTCTGCCTCCTCCTCTAGCTGGGCCTCC
TAATCGAGGAGATCGCCCTCCACCACCAGTTCTTTTTCCTGGACAACCTTTTGGGCAGCCTCCATTGGGTCCACTTCCTCCTGGCCCTCC
ACCTCCAGTTCCAGGCTACGGCCCCCCTCCTGGCCCACCACCTCCACAACAGGGACCACCTCCACCTCCAGGCCCCTTTCCACCTCGTCC
ACCCGGTCCACTTGGGCCACCCCTTACACTAGCTCCTCCTCCGCATCTTCCTGGACCACCTCCAGGTGCCCCACCGCCAGCTCCGCATGT
GAACCCAGCTTTCTTTCCTCCACCAACTAACAGTGGCATGCCTACATCAGATAGCCGAGGTCCACCACCAACAGATCCATATGGGCGACC
TCCACCATATGATAGGGGTGACTATGGCCCCCCTGGAAGGGAAATGGATACTGCAAGAACGCCATTGAGTGAAGCTGAATTTGAAGAAAT
CATGAATAGAAATAGGGCAATCTCAAGCAGTGCTATTTCGAGAGCTGTGTCTGATGCCAGTGCTGGTGATTATGGGAGTGCTATTGAGAC
ACTGGTAACTGCAATTTCTTTAATTAAACAATCCAAAGTATCTGCTGATGATCGTTGCAAAGTTCTTATTAGTTCTTTGCAAGATTGCCT
TCATGGAATTGAGTCCAAGTCTTATGGTTCTGGATCAAGACGTGAACGATCAAGAGAGAGGGACCATAGTAGATCACGAGAAAAGAGTCG
ACGTCATAAATCCCGTAGTAGAGACCGTCATGACGATTATTACAGAGAGAGAAGCAGAGAACGAGAGAGGCACCGGGATCGTGACCGAGA
CCGTGACCGAGAGCGTGACCGAGAGCGCGAATATCGTCATCGTTAGAAGCTGAAGGAAGAGGATCACCTTCCAAGACAAAACAGTCTTCA
TGGGGGAAAAATGACGCTTGTCCAGCAGTTTGCTTCTTGTGATTGAACTGAACCTGTAAGGATTCATGGATAAAATGAACAGGAATAGAT
CTGAATAAAGCAAATCTGCATAAATGGTAACCAGTAGCTCTACTTTTATTTTTTATGTTGCTTAACTGTTTTATTTGAAGGAAACCTGTG
TGATTTAAAAAGTTATAGCTTTTGCAACTTTATTACTGGTTATATACATTTGGCCATTATGATGTGCAAGCAATTGGAAAAAAAGTCAAG
TAAATGCTTGTTTTTGTAGTAGTTTGTTCTTGTTAAAAATGTTTATATGATAATGTCTGTAAACAGCATCACTTTGATTACAATAGATGT
AGTGTTGTAATAAACTGTTTAATGGGGCTGATGTGTAAAGCTGTTCAAGTTATTTGATGTTTACACCTCAGGGAAAGTCTTGTGTTCAGC
AATATCTAAAGATAATGTTACTATGACAACATTTTTACTGTCCTTTAAAGCATTGCAATAGCGTTTTTGGATATGCCTCAATCTAATCTT
GCGTTCAGTGAATTAAACATAGTAATTAAGTGTCTTTTGCCCTTGATTTTGATATTAGAATAGGTGATTACATGGATATTTAATATTTCT
ATATTCTGCTTTTCTAGCTGTTTTTACCTAGTTAGCTTGTGACTTTGCTGAATGGTATGTAAACTTGTAAAAATAGAGATTTGACAGACA
TAGCAATCTAGTCAATGTGTAAGGGGTCAAAAAAACAGAGGTTTTAACACATAAGTAAAAACCCGTACATATTTGATGTGTAATGCAGGT
TAATTACAACACAGATGTACCGAAACACTTAATTGTGAACCGCTAACATTGAAGAAATTTTGACAATTCCGATTTGATGCTGCAATTACT
TGCTGTTTTTATTGATCTTATGGTTTATTTCTTAAGCCATAGTCAGTGTAAATACAGCCCTGCAGCAGGTAAATGTGAGTAAAGAGAGCC
TTATATTTTCCAATTGGTATAAATTTTTGAAGGATGTGATGTTCATTAACATTCGGTTGTATTCCCCAGTATTTGTAATGGGAAATTACA
GATAAACCGTGTCTGCACAGTTTAAGGAATACTATGTATATTCATGCACCGTATTGATTCATGCTATAGTTACTTAATCAAAGATTTTTT
TCAAACCTGCCTTACATATAGGCCCACTTTAAAAGCACCTGACTAGCATGTGTTCTTGATTGCAAAATTGGCAGAGGCAGGGTGTCAACT
TGATTAGGTGTTTTTATGGGAATGTAATTTGAAATCACTACTTCAGAAATTTGACTTAAAATTCTTGAGCACGTTAATATGTTTTTAAGA
TCTGATTATCTTTGAGAGATCTTCTGTTAATACACATTGGTTGTTAAAGAGTACCCAAATTCTAGGACAATGCTTAAAGTGTTAAAATAC
CCTAGATACTGTGTTATGTGCAACTGTAGAAACCCTCCAGAAATTTCCACTGCTGTTCTTCACTTTCATCTTGTCTGCTATCAAACCACT
TCTGACAAAATTAGCTGTTTTGAATTACCCATATCACTGCCAGTTTTATTTTAAAATATTTTGTGTTTGAAGTATCTGTGCATGGGATCG
TTGATGTTTATCAGAACTGTTCACTTTCAGAAATGATTTTTTAAAGCATTTTGTTGAAAATGCGGTTGCTTTTTTAACATTATTTTAGAG
TTGTATCAAAATTTTCCTGTTTTCTGTATATTGTTGTGTCATTTCTTGGCTTTTTAATATTTTGACTACAATGCCCTAATGCGAAGAAGT
ATGGACATATAAATATTACAAGAGAAATTAGTTAATAGTAAAGGGTTAAAAGGTAAGTAAAATGTCCATGAAAATAAAATTTTCTTTGAA
CAGTTTAAAAATGGAATCACAAAAATCTAACTGCACTTGAAATGAAACTGGAAATTTTATACTAATTAAATCCTTTATTTACCTTTTCAT
ATTTTATCAATGGAACCTTTTAATTGCTCCTTCTATATCACTCTTCTCCTTGCTTGGCTGATCTCATTACATGACTTTCGTTACAGACAG
TGTGAGTGTACTAGATTTGTTTGCTGCTAATCCGTTATTTTAAGTGTTGTCAGAAGGAAATAACTTCTTGGTTTGACCAAGTAATTTTGC
AAAGTCCTTCTCTACCTGATAACACGTGAATGTATAGCAGTAAAGGTGAAAATTGCAGGCCTTGTTTTGTTCTTCATACCCCCTTCAGTT
GTTTATGGGTTAATGTTATTTGAAAACTCTTCCTTTTTTTAATGTGTAAAAACAATCCAAAGAGATAAATCCTTGCATAGACACCAAAAA
CAGTGTCTCAGAGACCTTTTCATTTTTTCCTTAGTTAATAACTGTAGTGGATGTGAAAACAAACGAGTTGAATTTTAAAACATAGCATTT
ATTAGTGCTATACAGTCACATTCCTTTCAGCCAGTAGTAAAGTTAAACAGATGAGTGATACAGTACCTGAATGGTACTGCTTCTGAGGCA
ACACTTTGGATTGAAAGTGCTGCTTTTGGTTAAAGGAACTATGTTGTGGAAAGCATATTCCAGTGTAAATTTGCAGATGTGTGTTTTTTT
TTTTTGTCACTTTTCATAAGGTTTGGAGTAAGTTGCAGTGGCTTTTGATCATAGTTTAGCCCATTTAATGGTCCTTTTACCTAGAATGTT
CTTAAGCAGTTAATGACAATTTGGAATACACAGATAACTTGTAGCTTAAGATACTATTTTCATTTAATTCTCCTGTGGAGAATATTGCTT
TATTTTTTACTAGTTTCAGGTCAGTTATTAAAATAAACATGGAGGTTTTAATGAATGTTGTATAATATTTTATAGTGAAGGAAAATTGTG
GAAAGGGCAAAGACTTTCTCTTTCCCTTATGTATTTAACTGTGCCAATCTAAATACATACTGTTTTATACAATGAGATGCATTACAAGAC
TTTTCTGTTGGAGTGCTCTCGACATTTTGGTTTTCATACCTGAATGATCATTGCATTTTCTGTATTTTCTAAAATGGCTCCAATTTTGTG
TTTTAAGCTTCAGCTTAAGAGGAAGTTTATGTTCTAATTCTTGACTGAGAATACAGTATTGAGATTCTCTGTTTTACAGATAACAACTGG
TTTTTATTACTCATTAAGTTCATTTGCATCCCGTAGCCCTCTGTAAATGTTTCCCCTAGTTGTATGTACGTAAATGCACGCTTATCCAGT
GTATATTAGACATTTTTGTGCTAAAATATATTAAGTGGGATTTTTGTAGCAAAGCATTCTATTTTTCTGTTCTTACAGTGTGTGTGTGTG
TGTGTGTGTGTGTGTATGCGTTTTTTTAACCTTAACTTCAGTTTAAACACTGGTGTATTTATTTTTTTAAGCAACTTGACTCTTAGAAGC
CTTAGACTGATTTTTTCAATAAATATTCAACCAAAAATTATAAATTTATTAAGATGTGGCCTTACATATGGCATTCCTTGTGTTCGTAAT
GTGAGATTTTTGATTTAGATAAATCAAGATTCAGGATTAAAGTTTCATTGTAAGTTGAAATAGAAAATGTATTAAAATGTCTAGGCTTCT
GGGAGGAAGTTCTTATACTCTTCTTTCTTGGCATTAGAAAGAAGCAATATGAATTTTTGTGAATATTCTAAATATTCAGGCAACACTGTT
CAGATTGATTTAGGTTTGTCTTAACCAATGTTCTTTTTTTAGAATTTCAGGTTGTGGCATTCACTGAGTATGCAGCTACTATGGTTTTTG
TATGGGACGTATAAATACTTGATTATATACGACAGATTTTAATGTCTTTAAAGACTTCCTGCTGTATTAACATATTGTAATGGAGTCTTT
TAAATACTAGGTTGAATTTAATTGAAGTCACACACATCTTGAAGTGGTAACTGCATAGTAAATACTACCAAGAGTTTTTTTCACGTGGGA
GTATCCTAAAACTCTGCCATGGGTGTAAATGTTTTACATTAATTTCATAATTGGACAGACCCTGCATTTAGCGAAAACATTTTGTTTTGA
AAGTGTGTTCTTTTTGTCGCACTGTTACTGCGTAACACTTCTCAACATTCTGTAAGTTAAATTATTTTAAAATAACTATGGTGAATTCAT
GTTTATTTTTTTACTTTGAAAATTGTAGTACTCAGGTGGTATTTAATGGGAAAGGATCCTTTGGGTATAAATCATAATGTATTTTAAGGA
ATGCATCTATAACATTGATAACTTTAGCCTTAAAAAAAAGGTCTATTATTCCTTCCTCTGCATCCCATGGTATATTAGCAAAGTAGTTTA
CAGCCCTGTACAGCCTTACAAAGTTGTTTTACAATTTTTAATGGAAAGCCCTTAACAACAACAACAAAAAATTGTATCATTTTACCAATA
TCCACGAATTACTGATCACAGTTTGTAAATAATTTGTTTAATATCAGAAGGCCAAAGAAAGTCTTAAAATTTTAGCTATTGACTCTATGG
TGACTTCACAATAAGATTTCTGTGCAAAAAGGTAAGGTGATAATTGATCTAATAGACTTTTTTTTTTTTTTTTTTGCTGTCCATGAGAAT
TAGACTTCATATTAGCTTCAATTAAAAAGCTCATTCCATTTTATTAAAATGTTTGTAATTGCAATTTTGTGTTTAATGTTTACTTTGTCT
TTCCTTTCTTTAGCATTTAGGTGACTGTTCGGCAGTTTGATATATGGCCATTGTCGGCCTTAAACTGCACTAGTAACAAGCATGGTATTT

>92510_92510_5_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000548305_CPSF6_chr12_69644909_ENST00000435070_length(amino acids)=768AA_BP=237
MLPLLPSRWEPSRREGGGEMIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTL
SFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCST
RGYSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYM
DTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDL
LPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPAG
QTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPF
PPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAE
FEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYGSGSRRERSRERDHSRSR

--------------------------------------------------------------
>92510_92510_6_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000548305_CPSF6_chr12_69644909_ENST00000456847_length(transcript)=3048nt_BP=1240nt
GGGAGCTAATAAACATTGAATGTGCAGCAGCTGCCTTGGCGGCCGGAGTCCGCCCGAGCGACACCGGAGCAGTGCGCCCGGGAGGCGGCG
AGGGGAGGCGGTTCGCCTTGTCCCTCCCACCCGCGCCTCTTTCTCTCTCTTCCTCCAGCTGGTCCCAGAGCCCGGCTTGGTCCGGTCCCT
CTGCCCCCATCCCGCACCCTTCCACCTCCTCCGAGTCCCACTCCTCACCTAGGACGCCCCAAACTGCCATGGGTTAGGGTGGGGATCGCG
ACCCGCGCGAAAGACCAGCCCTGCGCTTCCGCCGGGGGACGCGGAGCCCAAACGCCGCTCACCGCTTGCGGGCGCCGGGCATGGGGAGTG
TGGTGTGAGCCCGCACCCGGGGAGGACGCAGGAGCTGCGGAGACGGGCGCGAGGAGGAGGAGAGGAGTCGTGGATTGGAAGGACCCGAGG
GAGGGAGGGTGGGGAAGCGAGGGAAAAGTGAAGCTGGGAGGAGAAGGCGGCGGAAGGTGGAGATTGATGCTTCTGTTTTTTGTTGCCGCT
GCTGCCCTCGCGCTGGGAGCCGAGCCGGAGGGAAGGCGGTGGAGAGATGATTGCAGAGTTGGTGAGCAGCGCTCTGGGGCTCGCCTTGTA
TCTCAACACCCTGAGTGCGGATTTCTGCTATGATGACAGCCGTGCTATCAAGACTAATCAGGACCTTCTCCCAGAAACTCCATGGACGCA
CATTTTCTACAATGATTTTTGGGGGACTCTTCTAACCCACAGTGGCAGCCACAAGTCCTACCGGCCACTCTGCACTCTTTCTTTTCGCCT
GAACCATGCCATTGGAGGGTTGAATCCCTGGAGCTACCATCTTGTCAATGTCCTGTTGCATGCAGCAGTCACTGGTCTCTTCACAAGCTT
CTCCAAGATCCTCCTTGGTGATGGATACTGGACATTCATGGCTGGCTTGATGTTTGCTTCTCACCCCATTCACACGGAGGCAGTGGCAGG
AATCGTGGGACGAGCCGATGTCGGGGCCAGTCTCTTCTTTCTCCTCTCCTTGCTCTGCTACATTAAACACTGTTCTACAAGAGGCTACTC
AGCCAGAACCTGGGGCTGGTTCCTGGGGTCAGGACTGTGCGCAGGATGCAGCATGTTGTGGAAGGAACAAGGAGTGACTGTTCTCGCAGT
TTCAGCAGTTTATGATGTCTTTGTCTTTCACAGGCTGAAAATAAAACAGATATTACCTACCATTTACAAAGAAGCTGAATATGGTGGGCA
TGATCAGATAGATTTGTATGACGATGTCATATCTCCATCTGCAAATAATGGAGATGCCCCAGAAGACCGAGATTACATGGATACTCTCCC
ACCAACTGTTGGTGATGATGTGGGTAAAGGAGCAGCACCAAATGTTGTCTATACATATACTGGAAAGAGAATTGCATTATATATTGGAAA
TCTAACATGGTGGACAACAGATGAAGACTTAACTGAAGCAGTTCATTCTTTGGGAGTAAATGATATTTTGGAGATAAAATTTTTTGAAAA
TCGGGCAAATGGCCAGTCAAAGGGGTTTGCCCTTGTTGGTGTTGGATCTGAAGCATCTTCAAAAAAGTTAATGGATCTGTTACCTAAAAG
AGAACTTCATGGTCAGAATCCTGTTGTAACTCCATGCAATAAACAGTTCCTGAGTCAATTTGAAATGCAGTCCAGGAAAACTACACAATC
AGGACAAATGTCTGGGGAAGGTAAAGCTGGTCCTCCAGGAGCTGGGCCTCCTAATCGAGGAGATCGCCCTCCACCACCAGTTCTTTTTCC
TGGACAACCTTTTGGGCAGCCTCCATTGGGTCCACTTCCTCCTGGCCCTCCACCTCCAGTTCCAGGCTACGGCCCCCCTCCTGGCCCACC
ACCTCCACAACAGGGACCACCTCCACCTCCAGGCCCCTTTCCACCTCGTCCACCCGGTCCACTTGGGCCACCCCTTACACTAGCTCCTCC
TCCGCATCTTCCTGGACCACCTCCAGGTGCCCCACCGCCAGCTCCGCATGTGAACCCAGCTTTCTTTCCTCCACCAACTAACAGTGGCAT
GCCTACATCAGATAGCCGAGGTCCACCACCAACAGATCCATATGGGCGACCTCCACCATATGATAGGGGTGACTATGGCCCCCCTGGAAG
GGAAATGGATACTGCAAGAACGCCATTGAGTGAAGCTGAATTTGAAGAAATCATGAATAGAAATAGGGCAATCTCAAGCAGTGCTATTTC
GAGAGCTGTGTCTGATGCCAGTGCTGGTGATTATGGGAGTGCTATTGAGACACTGGTAACTGCAATTTCTTTAATTAAACAATCCAAAGT
ATCTGCTGATGATCGTTGCAAAGTTCTTATTAGTTCTTTGCAAGATTGCCTTCATGGAATTGAGTCCAAGTCTTATGGTTCTGGATCAAG
ACGTGAACGATCAAGAGAGAGGGACCATAGTAGATCACGAGAAAAGAGTCGACGTCATAAATCCCGTAGTAGAGACCGTCATGACGATTA
TTACAGAGAGAGAAGCAGAGAACGAGAGAGGCACCGGGATCGTGACCGAGACCGTGACCGAGAGCGTGACCGAGAGCGCGAATATCGTCA
TCGTTAGAAGCTGAAGGAAGAGGATCACCTTCCAAGACAAAACAGTCTTCATGGGGGAAAAATGACGCTTGTCCAGCAGTTTGCTTCTTG
TGATTGAACTGAACCTGTAAGGATTCATGGATAAAATGAACAGGAATAGATCTGAATAAAGCAAATCTGCATAAATGGTAACCAGTAGCT
CTACTTTTATTTTTTATGTTGCTTAACTGTTTTATTTGAAGGAAACCTGTGTGATTTAAAAAGTTATAGCTTTTGCAACTTTATTACTGG
TTATATACATTTGGCCATTATGATGTGCAAGCAATTGGAAAAAAAGTCAAGTAAATGCTTGTTTTTGTAGTAGTTTGTTCTTGTTAAAAA

>92510_92510_6_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000548305_CPSF6_chr12_69644909_ENST00000456847_length(amino acids)=695AA_BP=237
MLPLLPSRWEPSRREGGGEMIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTL
SFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCST
RGYSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYM
DTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDL
LPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPP
PGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYG
PPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYG

--------------------------------------------------------------
>92510_92510_7_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000549919_CPSF6_chr12_69644909_ENST00000266679_length(transcript)=4579nt_BP=2441nt
TCTAGAGTTATCAATCTGAATTATAAATTTTGTAAAATTATTCACAAAAGCACTTATTTTGTAAGTGTAGTGTAGAATGTTAGATGTATG
ACCTATAATTAATTCCATTAATCCTCAAATAAAACTGTGGAATCATTTTCCTTTCAAACAGCAGTTTAAATTCAAACTGTATTACCATTA
GCATAAGAATAGCTTTTAACAATAATTAAAATCCTAATGGTATCATGAAATAATTTTAGTTTAGTTATCCTTTTGATGTAAATATTTATC
CAGTGGGAGAACCTGATTTGTTAAACATTTTATATGAATTTGATTTGAGAAATGCACAGCACCATATAAATATATCACTGTAGGAGGCAG
TGTAGCCATAAGGAAAACATACCGGATTGAGTGTCAAGAACTGGTGTCTGTATGGTGCTGTACTGCACAAGCTTCATATGACCTTAATTT
CCGAGCATCAGTTTCATCATTGGTTAAAAAAAAAGAGATGACAGTATCAGACTTGCCTCACGGCTGTCTGCCAATTAAGTGAATTAGAAA
ATTATTTTCAATTATATAGTGCTGGGCAAGGTGAATGATTGCTATTACTGTTGTCATCACTGTTGTTTGAAGCACTGTGCTTTGGGAAGC
AAATCTGGTTCACATCTTTTGAACATTTAAATGAAGAGAATGTGTCTCAGTGCTCTAGTGTGTATTAAAACAGCCTTTTAACAAGAATGT
TTTGAACCCTGCCCAATACCTGCACATGCTTTTGTTAATACTTCATTACATAAAATGACCAAGAAGCTGTCATAAGAATTTAAAGGAACA
TTTACCCTCATCTTTAAAATGTATCTTAAAAGAGAGATAAGATTCTAATTACAAATTTTGAACAGTTTATTTTCTCTCTATGAAAAATTT
CCAAGAATGATACAAAAGCACTTTTATGTGAAGAGGATACACTGGAACATTGAGGTCTTGATCTCATTTTAGTAACTCTCTGATGTGATT
AATTCATAAGCACTGAGTTGTAGCTCATTCCTTCTGGCAAAATTCCAGCACTTGATTGTTACCTTATAAACTTTTAATAAGAGTAATTTT
AAAAACTGCACTTGACTCTTGCTTTATGAAAAGCTGGAAATGTAAAAAGTTAAAAATGCTTGACAATTTTTCTGAGCTCTAGTCAGAAAC
AGTGGCTATGCCCTTTTATAGATGACAGCCCAAAGGCGAGTTTGTAAAACGATAAATAAATTGTAAAGATCTATCGAGTGGCAACTTGGA
TGGTTTAATGCCTATGGGTTAGAAACCCAGGAGTTAATGTTTAAAGTGATTTGGATAAATGTGAACATGTTTAAATCTTTAGTATTATTC
CTTTAAGCCAAATGTGAACGATAGTTATTTTGACAAAGTTTGGGTTACCTCGATAGCCTGATTTTTACAGAAGTACCGTGTATCTCAAAT
TGTTAACTGATGAATGGGTGGTGCTGCTGGATTATTTCCTGTGTTTTGTGTTTTTCTTAGTTTTAATTTCTTTGTTATTCAAGTTATACT
ATCACCTCGTCCAAAGTTGGGTCTCAGGATTAGATTAATAAACTAACCAAGTAAATTTGGGAAGTATGACTAACTTACATAAAGAAAATA
ATTGGGGTTATTTTTTTGTATTATTATTTTAAAATATGTAATCAGCACTTTTGAGAAGCTCTCATTTTGTTGAATCTCTAGGCAGACCTT
TGTGGTTAAGCATCATCCTGGAAATTTTTTCTGACAGTCATTTGACCAGGTCTTTCTGTTTATACTCAGTGTCAAAACAACAACAACAAA
AATGCATGGAACCATCTAGTTGCAGGAAAACAAGCTCAGGACTCAGGACTCCCACTGATTATACATTATGCCGTGCTATCAAGACTAATC
AGGACCTTCTCCCAGAAACTCCATGGACGCACATTTTCTACAATGATTTTTGGGGGACTCTTCTAACCCACAGTGGCAGCCACAAGTCCT
ACCGGCCACTCTGCACTCTTTCTTTTCGCCTGAACCATGCCATTGGAGGGTTGAATCCCTGGAGCTACCATCTTGTCAATGTCCTGTTGC
ATGCAGCAGTCACTGGTCTCTTCACAAGCTTCTCCAAGATCCTCCTTGGTGATGGATACTGGACATTCATGGCTGGCTTGATGTTTGCTT
CTCACCCCATTCACACGGAGGCAGTGGCAGGAATCGTGGGACGAGCCGATGTCGGGGCCAGTCTCTTCTTTCTCCTCTCCTTGCTCTGCT
ACATTAAACACTGTTCTACAAGAGGCTACTCAGCCAGAACCTGGGGCTGGTTCCTGGGGTCAGGACTGTGCGCAGGATGCAGCATGTTGT
GGAAGGAACAAGGAGTGACTGTTCTCGCAGTTTCAGCAGTTTATGATGTCTTTGTCTTTCACAGGCTGAAAATAAAACAGATATTACCTA
CCATTTACAAAGAAGCTGAATATGGTGGGCATGATCAGATAGATTTGTATGACGATGTCATATCTCCATCTGCAAATAATGGAGATGCCC
CAGAAGACCGAGATTACATGGATACTCTCCCACCAACTGTTGGTGATGATGTGGGTAAAGGAGCAGCACCAAATGTTGTCTATACATATA
CTGGAAAGAGAATTGCATTATATATTGGAAATCTAACATGGTGGACAACAGATGAAGACTTAACTGAAGCAGTTCATTCTTTGGGAGTAA
ATGATATTTTGGAGATAAAATTTTTTGAAAATCGGGCAAATGGCCAGTCAAAGGGGTTTGCCCTTGTTGGTGTTGGATCTGAAGCATCTT
CAAAAAAGTTAATGGATCTGTTACCTAAAAGAGAACTTCATGGTCAGAATCCTGTTGTAACTCCATGCAATAAACAGTTCCTGAGTCAAT
TTGAAATGCAGTCCAGGAAAACTACACAATCAGGACAAATGTCTGGGGAAGGTAAAGCTGGTCCTCCAGGAGGCAGTTCCCGTGCAGCAT
TTCCACAAGGTGGTAGAGGACGGGGCCGTTTTCCAGGGGCTGTTCCTGGTGGGGACAGATTTCCTGGGCCAGCAGGACCAGGAGGGCCAC
CCCCACCTTTTCCAGGAAATTTGATCAAGCATCTTGTTAAAGGAACTCGGCCTTTGTTCCTGGAAACTAGGATTCCATGGCATATGGGGC
ACAGCATAGAGGAAATACCCATTTTTGGCCTAAAAGCTGGACAGACTCCACCACGTCCACCCTTAGGTCCTCCAGGCCCACCTGGTCCAC
CAGGTCCTCCACCTCCTGGTCAGGTTCTGCCTCCTCCTCTAGCTGGGCCTCCTAATCGAGGAGATCGCCCTCCACCACCAGTTCTTTTTC
CTGGACAACCTTTTGGGCAGCCTCCATTGGGTCCACTTCCTCCTGGCCCTCCACCTCCAGTTCCAGGCTACGGCCCCCCTCCTGGCCCAC
CACCTCCACAACAGGGACCACCTCCACCTCCAGGCCCCTTTCCACCTCGTCCACCCGGTCCACTTGGGCCACCCCTTACACTAGCTCCTC
CTCCGCATCTTCCTGGACCACCTCCAGGTGCCCCACCGCCAGCTCCGCATGTGAACCCAGCTTTCTTTCCTCCACCAACTAACAGTGGCA
TGCCTACATCAGATAGCCGAGGTCCACCACCAACAGATCCATATGGGCGACCTCCACCATATGATAGGGGTGACTATGGCCCCCCTGGAA
GGGAAATGGATACTGCAAGAACGCCATTGAGTGAAGCTGAATTTGAAGAAATCATGAATAGAAATAGGGCAATCTCAAGCAGTGCTATTT
CGAGAGCTGTGTCTGATGCCAGTGCTGGTGATTATGGGAGTGCTATTGAGACACTGGTAACTGCAATTTCTTTAATTAAACAATCCAAAG
TATCTGCTGATGATCGTTGCAAAGTTCTTATTAGTTCTTTGCAAGATTGCCTTCATGGAATTGAGTCCAAGTCTTATGGTTCTGGATCAA
GACGTGAACGATCAAGAGAGAGGGACCATAGTAGATCACGAGAAAAGAGTCGACGTCATAAATCCCGTAGTAGAGACCGTCATGACGATT
ATTACAGAGAGAGAAGCAGAGAACGAGAGAGGCACCGGGATCGTGACCGAGACCGTGACCGAGAGCGTGACCGAGAGCGCGAATATCGTC
ATCGTTAGAAGCTGAAGGAAGAGGATCACCTTCCAAGACAAAACAGTCTTCATGGGGGAAAAATGACGCTTGTCCAGCAGTTTGCTTCTT
GTGATTGAACTGAACCTGTAAGGATTCATGGATAAAATGAACAGGAATAGATCTGAATAAAGCAAATCTGCATAAATGGTAACCAGTAGC
TCTACTTTTATTTTTTATGTTGCTTAACTGTTTTATTTGAAGGAAACCTGTGTGATTTAAAAAGTTATAGCTTTTGCAACTTTATTACTG
GTTATATACATTTGGCCATTATGATGTGCAAGCAATTGGAAAAAAAGTCAAGTAAATGCTTGTTTTTGTAGTAGTTTGTTCTTGTTAAAA

>92510_92510_7_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000549919_CPSF6_chr12_69644909_ENST00000266679_length(amino acids)=825AA_BP=257
MRSSHFVESLGRPLWLSIILEIFSDSHLTRSFCLYSVSKQQQQKCMEPSSCRKTSSGLRTPTDYTLCRAIKTNQDLLPETPWTHIFYNDF
WGTLLTHSGSHKSYRPLCTLSFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRAD
VGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKEAEYGGHDQIDLY
DDVISPSANNGDAPEDRDYMDTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQS
KGFALVGVGSEASSKKLMDLLPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPG
GDRFPGPAGPGGPPPPFPGNLIKHLVKGTRPLFLETRIPWHMGHSIEEIPIFGLKAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGP
PNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPH
VNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIE
TLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYGSGSRRERSRERDHSRSREKSRRHKSRSRDRHDDYYRERSRERERHRDRDR

--------------------------------------------------------------
>92510_92510_8_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000549919_CPSF6_chr12_69644909_ENST00000435070_length(transcript)=8887nt_BP=2441nt
TCTAGAGTTATCAATCTGAATTATAAATTTTGTAAAATTATTCACAAAAGCACTTATTTTGTAAGTGTAGTGTAGAATGTTAGATGTATG
ACCTATAATTAATTCCATTAATCCTCAAATAAAACTGTGGAATCATTTTCCTTTCAAACAGCAGTTTAAATTCAAACTGTATTACCATTA
GCATAAGAATAGCTTTTAACAATAATTAAAATCCTAATGGTATCATGAAATAATTTTAGTTTAGTTATCCTTTTGATGTAAATATTTATC
CAGTGGGAGAACCTGATTTGTTAAACATTTTATATGAATTTGATTTGAGAAATGCACAGCACCATATAAATATATCACTGTAGGAGGCAG
TGTAGCCATAAGGAAAACATACCGGATTGAGTGTCAAGAACTGGTGTCTGTATGGTGCTGTACTGCACAAGCTTCATATGACCTTAATTT
CCGAGCATCAGTTTCATCATTGGTTAAAAAAAAAGAGATGACAGTATCAGACTTGCCTCACGGCTGTCTGCCAATTAAGTGAATTAGAAA
ATTATTTTCAATTATATAGTGCTGGGCAAGGTGAATGATTGCTATTACTGTTGTCATCACTGTTGTTTGAAGCACTGTGCTTTGGGAAGC
AAATCTGGTTCACATCTTTTGAACATTTAAATGAAGAGAATGTGTCTCAGTGCTCTAGTGTGTATTAAAACAGCCTTTTAACAAGAATGT
TTTGAACCCTGCCCAATACCTGCACATGCTTTTGTTAATACTTCATTACATAAAATGACCAAGAAGCTGTCATAAGAATTTAAAGGAACA
TTTACCCTCATCTTTAAAATGTATCTTAAAAGAGAGATAAGATTCTAATTACAAATTTTGAACAGTTTATTTTCTCTCTATGAAAAATTT
CCAAGAATGATACAAAAGCACTTTTATGTGAAGAGGATACACTGGAACATTGAGGTCTTGATCTCATTTTAGTAACTCTCTGATGTGATT
AATTCATAAGCACTGAGTTGTAGCTCATTCCTTCTGGCAAAATTCCAGCACTTGATTGTTACCTTATAAACTTTTAATAAGAGTAATTTT
AAAAACTGCACTTGACTCTTGCTTTATGAAAAGCTGGAAATGTAAAAAGTTAAAAATGCTTGACAATTTTTCTGAGCTCTAGTCAGAAAC
AGTGGCTATGCCCTTTTATAGATGACAGCCCAAAGGCGAGTTTGTAAAACGATAAATAAATTGTAAAGATCTATCGAGTGGCAACTTGGA
TGGTTTAATGCCTATGGGTTAGAAACCCAGGAGTTAATGTTTAAAGTGATTTGGATAAATGTGAACATGTTTAAATCTTTAGTATTATTC
CTTTAAGCCAAATGTGAACGATAGTTATTTTGACAAAGTTTGGGTTACCTCGATAGCCTGATTTTTACAGAAGTACCGTGTATCTCAAAT
TGTTAACTGATGAATGGGTGGTGCTGCTGGATTATTTCCTGTGTTTTGTGTTTTTCTTAGTTTTAATTTCTTTGTTATTCAAGTTATACT
ATCACCTCGTCCAAAGTTGGGTCTCAGGATTAGATTAATAAACTAACCAAGTAAATTTGGGAAGTATGACTAACTTACATAAAGAAAATA
ATTGGGGTTATTTTTTTGTATTATTATTTTAAAATATGTAATCAGCACTTTTGAGAAGCTCTCATTTTGTTGAATCTCTAGGCAGACCTT
TGTGGTTAAGCATCATCCTGGAAATTTTTTCTGACAGTCATTTGACCAGGTCTTTCTGTTTATACTCAGTGTCAAAACAACAACAACAAA
AATGCATGGAACCATCTAGTTGCAGGAAAACAAGCTCAGGACTCAGGACTCCCACTGATTATACATTATGCCGTGCTATCAAGACTAATC
AGGACCTTCTCCCAGAAACTCCATGGACGCACATTTTCTACAATGATTTTTGGGGGACTCTTCTAACCCACAGTGGCAGCCACAAGTCCT
ACCGGCCACTCTGCACTCTTTCTTTTCGCCTGAACCATGCCATTGGAGGGTTGAATCCCTGGAGCTACCATCTTGTCAATGTCCTGTTGC
ATGCAGCAGTCACTGGTCTCTTCACAAGCTTCTCCAAGATCCTCCTTGGTGATGGATACTGGACATTCATGGCTGGCTTGATGTTTGCTT
CTCACCCCATTCACACGGAGGCAGTGGCAGGAATCGTGGGACGAGCCGATGTCGGGGCCAGTCTCTTCTTTCTCCTCTCCTTGCTCTGCT
ACATTAAACACTGTTCTACAAGAGGCTACTCAGCCAGAACCTGGGGCTGGTTCCTGGGGTCAGGACTGTGCGCAGGATGCAGCATGTTGT
GGAAGGAACAAGGAGTGACTGTTCTCGCAGTTTCAGCAGTTTATGATGTCTTTGTCTTTCACAGGCTGAAAATAAAACAGATATTACCTA
CCATTTACAAAGAAGCTGAATATGGTGGGCATGATCAGATAGATTTGTATGACGATGTCATATCTCCATCTGCAAATAATGGAGATGCCC
CAGAAGACCGAGATTACATGGATACTCTCCCACCAACTGTTGGTGATGATGTGGGTAAAGGAGCAGCACCAAATGTTGTCTATACATATA
CTGGAAAGAGAATTGCATTATATATTGGAAATCTAACATGGTGGACAACAGATGAAGACTTAACTGAAGCAGTTCATTCTTTGGGAGTAA
ATGATATTTTGGAGATAAAATTTTTTGAAAATCGGGCAAATGGCCAGTCAAAGGGGTTTGCCCTTGTTGGTGTTGGATCTGAAGCATCTT
CAAAAAAGTTAATGGATCTGTTACCTAAAAGAGAACTTCATGGTCAGAATCCTGTTGTAACTCCATGCAATAAACAGTTCCTGAGTCAAT
TTGAAATGCAGTCCAGGAAAACTACACAATCAGGACAAATGTCTGGGGAAGGTAAAGCTGGTCCTCCAGGAGGCAGTTCCCGTGCAGCAT
TTCCACAAGGTGGTAGAGGACGGGGCCGTTTTCCAGGGGCTGTTCCTGGTGGGGACAGATTTCCTGGGCCAGCAGGACCAGGAGGGCCAC
CCCCACCTTTTCCAGCTGGACAGACTCCACCACGTCCACCCTTAGGTCCTCCAGGCCCACCTGGTCCACCAGGTCCTCCACCTCCTGGTC
AGGTTCTGCCTCCTCCTCTAGCTGGGCCTCCTAATCGAGGAGATCGCCCTCCACCACCAGTTCTTTTTCCTGGACAACCTTTTGGGCAGC
CTCCATTGGGTCCACTTCCTCCTGGCCCTCCACCTCCAGTTCCAGGCTACGGCCCCCCTCCTGGCCCACCACCTCCACAACAGGGACCAC
CTCCACCTCCAGGCCCCTTTCCACCTCGTCCACCCGGTCCACTTGGGCCACCCCTTACACTAGCTCCTCCTCCGCATCTTCCTGGACCAC
CTCCAGGTGCCCCACCGCCAGCTCCGCATGTGAACCCAGCTTTCTTTCCTCCACCAACTAACAGTGGCATGCCTACATCAGATAGCCGAG
GTCCACCACCAACAGATCCATATGGGCGACCTCCACCATATGATAGGGGTGACTATGGCCCCCCTGGAAGGGAAATGGATACTGCAAGAA
CGCCATTGAGTGAAGCTGAATTTGAAGAAATCATGAATAGAAATAGGGCAATCTCAAGCAGTGCTATTTCGAGAGCTGTGTCTGATGCCA
GTGCTGGTGATTATGGGAGTGCTATTGAGACACTGGTAACTGCAATTTCTTTAATTAAACAATCCAAAGTATCTGCTGATGATCGTTGCA
AAGTTCTTATTAGTTCTTTGCAAGATTGCCTTCATGGAATTGAGTCCAAGTCTTATGGTTCTGGATCAAGACGTGAACGATCAAGAGAGA
GGGACCATAGTAGATCACGAGAAAAGAGTCGACGTCATAAATCCCGTAGTAGAGACCGTCATGACGATTATTACAGAGAGAGAAGCAGAG
AACGAGAGAGGCACCGGGATCGTGACCGAGACCGTGACCGAGAGCGTGACCGAGAGCGCGAATATCGTCATCGTTAGAAGCTGAAGGAAG
AGGATCACCTTCCAAGACAAAACAGTCTTCATGGGGGAAAAATGACGCTTGTCCAGCAGTTTGCTTCTTGTGATTGAACTGAACCTGTAA
GGATTCATGGATAAAATGAACAGGAATAGATCTGAATAAAGCAAATCTGCATAAATGGTAACCAGTAGCTCTACTTTTATTTTTTATGTT
GCTTAACTGTTTTATTTGAAGGAAACCTGTGTGATTTAAAAAGTTATAGCTTTTGCAACTTTATTACTGGTTATATACATTTGGCCATTA
TGATGTGCAAGCAATTGGAAAAAAAGTCAAGTAAATGCTTGTTTTTGTAGTAGTTTGTTCTTGTTAAAAATGTTTATATGATAATGTCTG
TAAACAGCATCACTTTGATTACAATAGATGTAGTGTTGTAATAAACTGTTTAATGGGGCTGATGTGTAAAGCTGTTCAAGTTATTTGATG
TTTACACCTCAGGGAAAGTCTTGTGTTCAGCAATATCTAAAGATAATGTTACTATGACAACATTTTTACTGTCCTTTAAAGCATTGCAAT
AGCGTTTTTGGATATGCCTCAATCTAATCTTGCGTTCAGTGAATTAAACATAGTAATTAAGTGTCTTTTGCCCTTGATTTTGATATTAGA
ATAGGTGATTACATGGATATTTAATATTTCTATATTCTGCTTTTCTAGCTGTTTTTACCTAGTTAGCTTGTGACTTTGCTGAATGGTATG
TAAACTTGTAAAAATAGAGATTTGACAGACATAGCAATCTAGTCAATGTGTAAGGGGTCAAAAAAACAGAGGTTTTAACACATAAGTAAA
AACCCGTACATATTTGATGTGTAATGCAGGTTAATTACAACACAGATGTACCGAAACACTTAATTGTGAACCGCTAACATTGAAGAAATT
TTGACAATTCCGATTTGATGCTGCAATTACTTGCTGTTTTTATTGATCTTATGGTTTATTTCTTAAGCCATAGTCAGTGTAAATACAGCC
CTGCAGCAGGTAAATGTGAGTAAAGAGAGCCTTATATTTTCCAATTGGTATAAATTTTTGAAGGATGTGATGTTCATTAACATTCGGTTG
TATTCCCCAGTATTTGTAATGGGAAATTACAGATAAACCGTGTCTGCACAGTTTAAGGAATACTATGTATATTCATGCACCGTATTGATT
CATGCTATAGTTACTTAATCAAAGATTTTTTTCAAACCTGCCTTACATATAGGCCCACTTTAAAAGCACCTGACTAGCATGTGTTCTTGA
TTGCAAAATTGGCAGAGGCAGGGTGTCAACTTGATTAGGTGTTTTTATGGGAATGTAATTTGAAATCACTACTTCAGAAATTTGACTTAA
AATTCTTGAGCACGTTAATATGTTTTTAAGATCTGATTATCTTTGAGAGATCTTCTGTTAATACACATTGGTTGTTAAAGAGTACCCAAA
TTCTAGGACAATGCTTAAAGTGTTAAAATACCCTAGATACTGTGTTATGTGCAACTGTAGAAACCCTCCAGAAATTTCCACTGCTGTTCT
TCACTTTCATCTTGTCTGCTATCAAACCACTTCTGACAAAATTAGCTGTTTTGAATTACCCATATCACTGCCAGTTTTATTTTAAAATAT
TTTGTGTTTGAAGTATCTGTGCATGGGATCGTTGATGTTTATCAGAACTGTTCACTTTCAGAAATGATTTTTTAAAGCATTTTGTTGAAA
ATGCGGTTGCTTTTTTAACATTATTTTAGAGTTGTATCAAAATTTTCCTGTTTTCTGTATATTGTTGTGTCATTTCTTGGCTTTTTAATA
TTTTGACTACAATGCCCTAATGCGAAGAAGTATGGACATATAAATATTACAAGAGAAATTAGTTAATAGTAAAGGGTTAAAAGGTAAGTA
AAATGTCCATGAAAATAAAATTTTCTTTGAACAGTTTAAAAATGGAATCACAAAAATCTAACTGCACTTGAAATGAAACTGGAAATTTTA
TACTAATTAAATCCTTTATTTACCTTTTCATATTTTATCAATGGAACCTTTTAATTGCTCCTTCTATATCACTCTTCTCCTTGCTTGGCT
GATCTCATTACATGACTTTCGTTACAGACAGTGTGAGTGTACTAGATTTGTTTGCTGCTAATCCGTTATTTTAAGTGTTGTCAGAAGGAA
ATAACTTCTTGGTTTGACCAAGTAATTTTGCAAAGTCCTTCTCTACCTGATAACACGTGAATGTATAGCAGTAAAGGTGAAAATTGCAGG
CCTTGTTTTGTTCTTCATACCCCCTTCAGTTGTTTATGGGTTAATGTTATTTGAAAACTCTTCCTTTTTTTAATGTGTAAAAACAATCCA
AAGAGATAAATCCTTGCATAGACACCAAAAACAGTGTCTCAGAGACCTTTTCATTTTTTCCTTAGTTAATAACTGTAGTGGATGTGAAAA
CAAACGAGTTGAATTTTAAAACATAGCATTTATTAGTGCTATACAGTCACATTCCTTTCAGCCAGTAGTAAAGTTAAACAGATGAGTGAT
ACAGTACCTGAATGGTACTGCTTCTGAGGCAACACTTTGGATTGAAAGTGCTGCTTTTGGTTAAAGGAACTATGTTGTGGAAAGCATATT
CCAGTGTAAATTTGCAGATGTGTGTTTTTTTTTTTTGTCACTTTTCATAAGGTTTGGAGTAAGTTGCAGTGGCTTTTGATCATAGTTTAG
CCCATTTAATGGTCCTTTTACCTAGAATGTTCTTAAGCAGTTAATGACAATTTGGAATACACAGATAACTTGTAGCTTAAGATACTATTT
TCATTTAATTCTCCTGTGGAGAATATTGCTTTATTTTTTACTAGTTTCAGGTCAGTTATTAAAATAAACATGGAGGTTTTAATGAATGTT
GTATAATATTTTATAGTGAAGGAAAATTGTGGAAAGGGCAAAGACTTTCTCTTTCCCTTATGTATTTAACTGTGCCAATCTAAATACATA
CTGTTTTATACAATGAGATGCATTACAAGACTTTTCTGTTGGAGTGCTCTCGACATTTTGGTTTTCATACCTGAATGATCATTGCATTTT
CTGTATTTTCTAAAATGGCTCCAATTTTGTGTTTTAAGCTTCAGCTTAAGAGGAAGTTTATGTTCTAATTCTTGACTGAGAATACAGTAT
TGAGATTCTCTGTTTTACAGATAACAACTGGTTTTTATTACTCATTAAGTTCATTTGCATCCCGTAGCCCTCTGTAAATGTTTCCCCTAG
TTGTATGTACGTAAATGCACGCTTATCCAGTGTATATTAGACATTTTTGTGCTAAAATATATTAAGTGGGATTTTTGTAGCAAAGCATTC
TATTTTTCTGTTCTTACAGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGCGTTTTTTTAACCTTAACTTCAGTTTAAACACTGGTGTATT
TATTTTTTTAAGCAACTTGACTCTTAGAAGCCTTAGACTGATTTTTTCAATAAATATTCAACCAAAAATTATAAATTTATTAAGATGTGG
CCTTACATATGGCATTCCTTGTGTTCGTAATGTGAGATTTTTGATTTAGATAAATCAAGATTCAGGATTAAAGTTTCATTGTAAGTTGAA
ATAGAAAATGTATTAAAATGTCTAGGCTTCTGGGAGGAAGTTCTTATACTCTTCTTTCTTGGCATTAGAAAGAAGCAATATGAATTTTTG
TGAATATTCTAAATATTCAGGCAACACTGTTCAGATTGATTTAGGTTTGTCTTAACCAATGTTCTTTTTTTAGAATTTCAGGTTGTGGCA
TTCACTGAGTATGCAGCTACTATGGTTTTTGTATGGGACGTATAAATACTTGATTATATACGACAGATTTTAATGTCTTTAAAGACTTCC
TGCTGTATTAACATATTGTAATGGAGTCTTTTAAATACTAGGTTGAATTTAATTGAAGTCACACACATCTTGAAGTGGTAACTGCATAGT
AAATACTACCAAGAGTTTTTTTCACGTGGGAGTATCCTAAAACTCTGCCATGGGTGTAAATGTTTTACATTAATTTCATAATTGGACAGA
CCCTGCATTTAGCGAAAACATTTTGTTTTGAAAGTGTGTTCTTTTTGTCGCACTGTTACTGCGTAACACTTCTCAACATTCTGTAAGTTA
AATTATTTTAAAATAACTATGGTGAATTCATGTTTATTTTTTTACTTTGAAAATTGTAGTACTCAGGTGGTATTTAATGGGAAAGGATCC
TTTGGGTATAAATCATAATGTATTTTAAGGAATGCATCTATAACATTGATAACTTTAGCCTTAAAAAAAAGGTCTATTATTCCTTCCTCT
GCATCCCATGGTATATTAGCAAAGTAGTTTACAGCCCTGTACAGCCTTACAAAGTTGTTTTACAATTTTTAATGGAAAGCCCTTAACAAC
AACAACAAAAAATTGTATCATTTTACCAATATCCACGAATTACTGATCACAGTTTGTAAATAATTTGTTTAATATCAGAAGGCCAAAGAA
AGTCTTAAAATTTTAGCTATTGACTCTATGGTGACTTCACAATAAGATTTCTGTGCAAAAAGGTAAGGTGATAATTGATCTAATAGACTT
TTTTTTTTTTTTTTTTGCTGTCCATGAGAATTAGACTTCATATTAGCTTCAATTAAAAAGCTCATTCCATTTTATTAAAATGTTTGTAAT
TGCAATTTTGTGTTTAATGTTTACTTTGTCTTTCCTTTCTTTAGCATTTAGGTGACTGTTCGGCAGTTTGATATATGGCCATTGTCGGCC

>92510_92510_8_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000549919_CPSF6_chr12_69644909_ENST00000435070_length(amino acids)=788AA_BP=257
MRSSHFVESLGRPLWLSIILEIFSDSHLTRSFCLYSVSKQQQQKCMEPSSCRKTSSGLRTPTDYTLCRAIKTNQDLLPETPWTHIFYNDF
WGTLLTHSGSHKSYRPLCTLSFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRAD
VGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKEAEYGGHDQIDLY
DDVISPSANNGDAPEDRDYMDTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQS
KGFALVGVGSEASSKKLMDLLPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPG
GDRFPGPAGPGGPPPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGY
GPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRG
DYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESK

--------------------------------------------------------------
>92510_92510_9_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000549919_CPSF6_chr12_69644909_ENST00000456847_length(transcript)=4249nt_BP=2441nt
TCTAGAGTTATCAATCTGAATTATAAATTTTGTAAAATTATTCACAAAAGCACTTATTTTGTAAGTGTAGTGTAGAATGTTAGATGTATG
ACCTATAATTAATTCCATTAATCCTCAAATAAAACTGTGGAATCATTTTCCTTTCAAACAGCAGTTTAAATTCAAACTGTATTACCATTA
GCATAAGAATAGCTTTTAACAATAATTAAAATCCTAATGGTATCATGAAATAATTTTAGTTTAGTTATCCTTTTGATGTAAATATTTATC
CAGTGGGAGAACCTGATTTGTTAAACATTTTATATGAATTTGATTTGAGAAATGCACAGCACCATATAAATATATCACTGTAGGAGGCAG
TGTAGCCATAAGGAAAACATACCGGATTGAGTGTCAAGAACTGGTGTCTGTATGGTGCTGTACTGCACAAGCTTCATATGACCTTAATTT
CCGAGCATCAGTTTCATCATTGGTTAAAAAAAAAGAGATGACAGTATCAGACTTGCCTCACGGCTGTCTGCCAATTAAGTGAATTAGAAA
ATTATTTTCAATTATATAGTGCTGGGCAAGGTGAATGATTGCTATTACTGTTGTCATCACTGTTGTTTGAAGCACTGTGCTTTGGGAAGC
AAATCTGGTTCACATCTTTTGAACATTTAAATGAAGAGAATGTGTCTCAGTGCTCTAGTGTGTATTAAAACAGCCTTTTAACAAGAATGT
TTTGAACCCTGCCCAATACCTGCACATGCTTTTGTTAATACTTCATTACATAAAATGACCAAGAAGCTGTCATAAGAATTTAAAGGAACA
TTTACCCTCATCTTTAAAATGTATCTTAAAAGAGAGATAAGATTCTAATTACAAATTTTGAACAGTTTATTTTCTCTCTATGAAAAATTT
CCAAGAATGATACAAAAGCACTTTTATGTGAAGAGGATACACTGGAACATTGAGGTCTTGATCTCATTTTAGTAACTCTCTGATGTGATT
AATTCATAAGCACTGAGTTGTAGCTCATTCCTTCTGGCAAAATTCCAGCACTTGATTGTTACCTTATAAACTTTTAATAAGAGTAATTTT
AAAAACTGCACTTGACTCTTGCTTTATGAAAAGCTGGAAATGTAAAAAGTTAAAAATGCTTGACAATTTTTCTGAGCTCTAGTCAGAAAC
AGTGGCTATGCCCTTTTATAGATGACAGCCCAAAGGCGAGTTTGTAAAACGATAAATAAATTGTAAAGATCTATCGAGTGGCAACTTGGA
TGGTTTAATGCCTATGGGTTAGAAACCCAGGAGTTAATGTTTAAAGTGATTTGGATAAATGTGAACATGTTTAAATCTTTAGTATTATTC
CTTTAAGCCAAATGTGAACGATAGTTATTTTGACAAAGTTTGGGTTACCTCGATAGCCTGATTTTTACAGAAGTACCGTGTATCTCAAAT
TGTTAACTGATGAATGGGTGGTGCTGCTGGATTATTTCCTGTGTTTTGTGTTTTTCTTAGTTTTAATTTCTTTGTTATTCAAGTTATACT
ATCACCTCGTCCAAAGTTGGGTCTCAGGATTAGATTAATAAACTAACCAAGTAAATTTGGGAAGTATGACTAACTTACATAAAGAAAATA
ATTGGGGTTATTTTTTTGTATTATTATTTTAAAATATGTAATCAGCACTTTTGAGAAGCTCTCATTTTGTTGAATCTCTAGGCAGACCTT
TGTGGTTAAGCATCATCCTGGAAATTTTTTCTGACAGTCATTTGACCAGGTCTTTCTGTTTATACTCAGTGTCAAAACAACAACAACAAA
AATGCATGGAACCATCTAGTTGCAGGAAAACAAGCTCAGGACTCAGGACTCCCACTGATTATACATTATGCCGTGCTATCAAGACTAATC
AGGACCTTCTCCCAGAAACTCCATGGACGCACATTTTCTACAATGATTTTTGGGGGACTCTTCTAACCCACAGTGGCAGCCACAAGTCCT
ACCGGCCACTCTGCACTCTTTCTTTTCGCCTGAACCATGCCATTGGAGGGTTGAATCCCTGGAGCTACCATCTTGTCAATGTCCTGTTGC
ATGCAGCAGTCACTGGTCTCTTCACAAGCTTCTCCAAGATCCTCCTTGGTGATGGATACTGGACATTCATGGCTGGCTTGATGTTTGCTT
CTCACCCCATTCACACGGAGGCAGTGGCAGGAATCGTGGGACGAGCCGATGTCGGGGCCAGTCTCTTCTTTCTCCTCTCCTTGCTCTGCT
ACATTAAACACTGTTCTACAAGAGGCTACTCAGCCAGAACCTGGGGCTGGTTCCTGGGGTCAGGACTGTGCGCAGGATGCAGCATGTTGT
GGAAGGAACAAGGAGTGACTGTTCTCGCAGTTTCAGCAGTTTATGATGTCTTTGTCTTTCACAGGCTGAAAATAAAACAGATATTACCTA
CCATTTACAAAGAAGCTGAATATGGTGGGCATGATCAGATAGATTTGTATGACGATGTCATATCTCCATCTGCAAATAATGGAGATGCCC
CAGAAGACCGAGATTACATGGATACTCTCCCACCAACTGTTGGTGATGATGTGGGTAAAGGAGCAGCACCAAATGTTGTCTATACATATA
CTGGAAAGAGAATTGCATTATATATTGGAAATCTAACATGGTGGACAACAGATGAAGACTTAACTGAAGCAGTTCATTCTTTGGGAGTAA
ATGATATTTTGGAGATAAAATTTTTTGAAAATCGGGCAAATGGCCAGTCAAAGGGGTTTGCCCTTGTTGGTGTTGGATCTGAAGCATCTT
CAAAAAAGTTAATGGATCTGTTACCTAAAAGAGAACTTCATGGTCAGAATCCTGTTGTAACTCCATGCAATAAACAGTTCCTGAGTCAAT
TTGAAATGCAGTCCAGGAAAACTACACAATCAGGACAAATGTCTGGGGAAGGTAAAGCTGGTCCTCCAGGAGCTGGGCCTCCTAATCGAG
GAGATCGCCCTCCACCACCAGTTCTTTTTCCTGGACAACCTTTTGGGCAGCCTCCATTGGGTCCACTTCCTCCTGGCCCTCCACCTCCAG
TTCCAGGCTACGGCCCCCCTCCTGGCCCACCACCTCCACAACAGGGACCACCTCCACCTCCAGGCCCCTTTCCACCTCGTCCACCCGGTC
CACTTGGGCCACCCCTTACACTAGCTCCTCCTCCGCATCTTCCTGGACCACCTCCAGGTGCCCCACCGCCAGCTCCGCATGTGAACCCAG
CTTTCTTTCCTCCACCAACTAACAGTGGCATGCCTACATCAGATAGCCGAGGTCCACCACCAACAGATCCATATGGGCGACCTCCACCAT
ATGATAGGGGTGACTATGGCCCCCCTGGAAGGGAAATGGATACTGCAAGAACGCCATTGAGTGAAGCTGAATTTGAAGAAATCATGAATA
GAAATAGGGCAATCTCAAGCAGTGCTATTTCGAGAGCTGTGTCTGATGCCAGTGCTGGTGATTATGGGAGTGCTATTGAGACACTGGTAA
CTGCAATTTCTTTAATTAAACAATCCAAAGTATCTGCTGATGATCGTTGCAAAGTTCTTATTAGTTCTTTGCAAGATTGCCTTCATGGAA
TTGAGTCCAAGTCTTATGGTTCTGGATCAAGACGTGAACGATCAAGAGAGAGGGACCATAGTAGATCACGAGAAAAGAGTCGACGTCATA
AATCCCGTAGTAGAGACCGTCATGACGATTATTACAGAGAGAGAAGCAGAGAACGAGAGAGGCACCGGGATCGTGACCGAGACCGTGACC
GAGAGCGTGACCGAGAGCGCGAATATCGTCATCGTTAGAAGCTGAAGGAAGAGGATCACCTTCCAAGACAAAACAGTCTTCATGGGGGAA
AAATGACGCTTGTCCAGCAGTTTGCTTCTTGTGATTGAACTGAACCTGTAAGGATTCATGGATAAAATGAACAGGAATAGATCTGAATAA
AGCAAATCTGCATAAATGGTAACCAGTAGCTCTACTTTTATTTTTTATGTTGCTTAACTGTTTTATTTGAAGGAAACCTGTGTGATTTAA
AAAGTTATAGCTTTTGCAACTTTATTACTGGTTATATACATTTGGCCATTATGATGTGCAAGCAATTGGAAAAAAAGTCAAGTAAATGCT
TGTTTTTGTAGTAGTTTGTTCTTGTTAAAAATGTTTATATGATAATGTCTGTAAACAGCATCACTTTGATTACAATAGATGTAGTGTTGT

>92510_92510_9_TMTC2-CPSF6_TMTC2_chr12_83251359_ENST00000549919_CPSF6_chr12_69644909_ENST00000456847_length(amino acids)=715AA_BP=257
MRSSHFVESLGRPLWLSIILEIFSDSHLTRSFCLYSVSKQQQQKCMEPSSCRKTSSGLRTPTDYTLCRAIKTNQDLLPETPWTHIFYNDF
WGTLLTHSGSHKSYRPLCTLSFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRAD
VGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKEAEYGGHDQIDLY
DDVISPSANNGDAPEDRDYMDTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQS
KGFALVGVGSEASSKKLMDLLPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGAGPPNRGDRPPPPVLFPGQPFGQ
PPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSR
GPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRC

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Fusion Gene PPI Analysis for TMTC2-CPSF6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMTC2-CPSF6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMTC2-CPSF6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource