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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:TMTC2-HERC1 (FusionGDB2 ID:92513) |
Fusion Gene Summary for TMTC2-HERC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMTC2-HERC1 | Fusion gene ID: 92513 | Hgene | Tgene | Gene symbol | TMTC2 | HERC1 | Gene ID | 160335 | 8925 |
| Gene name | transmembrane O-mannosyltransferase targeting cadherins 2 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | |
| Synonyms | IBDBP1 | MDFPMR|p532|p619 | |
| Cytomap | 12q21.31 | 15q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein O-mannosyl-transferase TMTC2transmembrane and TPR repeat-containing protein 2transmembrane and tetratricopeptide repeat containing 2 | probable E3 ubiquitin-protein ligase HERC1HECT domain and RCC1-like domain-containing protein 1HECT-type E3 ubiquitin transferase HERC1guanine nucleotide exchange factor p532hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | . | Q15751 | |
| Ensembl transtripts involved in fusion gene | ENST00000321196, ENST00000548305, ENST00000549919, | ENST00000443617, | |
| Fusion gene scores | * DoF score | 11 X 7 X 5=385 | 11 X 12 X 6=792 |
| # samples | 11 | 12 | |
| ** MAII score | log2(11/385*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/792*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMTC2 [Title/Abstract] AND HERC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | TMTC2(83081448)-HERC1(63956793), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across TMTC2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across HERC1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-DX-A1L4-01A | TMTC2 | chr12 | 83081448 | - | HERC1 | chr15 | 63956793 | - |
| ChimerDB4 | SARC | TCGA-DX-A1L4-01A | TMTC2 | chr12 | 83081448 | + | HERC1 | chr15 | 63956793 | - |
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Fusion Gene ORF analysis for TMTC2-HERC1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000321196 | ENST00000443617 | TMTC2 | chr12 | 83081448 | + | HERC1 | chr15 | 63956793 | - |
| In-frame | ENST00000548305 | ENST00000443617 | TMTC2 | chr12 | 83081448 | + | HERC1 | chr15 | 63956793 | - |
| intron-3CDS | ENST00000549919 | ENST00000443617 | TMTC2 | chr12 | 83081448 | + | HERC1 | chr15 | 63956793 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000321196 | TMTC2 | chr12 | 83081448 | + | ENST00000443617 | HERC1 | chr15 | 63956793 | - | 7284 | 790 | 650 | 6820 | 2056 |
| ENST00000548305 | TMTC2 | chr12 | 83081448 | + | ENST00000443617 | HERC1 | chr15 | 63956793 | - | 7163 | 669 | 529 | 6699 | 2056 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000321196 | ENST00000443617 | TMTC2 | chr12 | 83081448 | + | HERC1 | chr15 | 63956793 | - | 0.002396218 | 0.99760383 |
| ENST00000548305 | ENST00000443617 | TMTC2 | chr12 | 83081448 | + | HERC1 | chr15 | 63956793 | - | 0.002165918 | 0.99783415 |
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Fusion Genomic Features for TMTC2-HERC1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TMTC2-HERC1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:83081448/chr15:63956793) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | HERC1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 4501_4848 | 2851 | 4862.0 | Domain | HECT | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 3426_3465 | 2851 | 4862.0 | Repeat | Note=WD 1 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 3484_3522 | 2851 | 4862.0 | Repeat | Note=WD 2 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 3524_3572 | 2851 | 4862.0 | Repeat | Note=WD 3 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 3580_3619 | 2851 | 4862.0 | Repeat | Note=WD 4 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 3624_3663 | 2851 | 4862.0 | Repeat | Note=WD 5 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 3667_3713 | 2851 | 4862.0 | Repeat | Note=WD 6 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 3745_3784 | 2851 | 4862.0 | Repeat | Note=WD 7 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 3996_4044 | 2851 | 4862.0 | Repeat | Note=RCC1 8 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 4046_4099 | 2851 | 4862.0 | Repeat | Note=RCC1 9 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 4101_4151 | 2851 | 4862.0 | Repeat | Note=RCC1 10 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 4153_4203 | 2851 | 4862.0 | Repeat | Note=RCC1 11 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 4205_4256 | 2851 | 4862.0 | Repeat | Note=RCC1 12 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 4258_4308 | 2851 | 4862.0 | Repeat | Note=RCC1 13 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 4310_4360 | 2851 | 4862.0 | Repeat | Note=RCC1 14 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 462_492 | 27 | 837.0 | Repeat | Note=TPR 1 |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 493_526 | 27 | 837.0 | Repeat | Note=TPR 2 |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 527_560 | 27 | 837.0 | Repeat | Note=TPR 3 |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 562_594 | 27 | 837.0 | Repeat | Note=TPR 4 |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 606_639 | 27 | 837.0 | Repeat | Note=TPR 5 |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 643_676 | 27 | 837.0 | Repeat | Note=TPR 6 |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 677_710 | 27 | 837.0 | Repeat | Note=TPR 7 |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 712_744 | 27 | 837.0 | Repeat | Note=TPR 8 |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 746_778 | 27 | 837.0 | Repeat | Note=TPR 9 |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 779_812 | 27 | 837.0 | Repeat | Note=TPR 10 |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 108_128 | 27 | 837.0 | Transmembrane | Helical |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 133_153 | 27 | 837.0 | Transmembrane | Helical |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 163_183 | 27 | 837.0 | Transmembrane | Helical |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 184_204 | 27 | 837.0 | Transmembrane | Helical |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 222_241 | 27 | 837.0 | Transmembrane | Helical |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 313_333 | 27 | 837.0 | Transmembrane | Helical |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 400_420 | 27 | 837.0 | Transmembrane | Helical |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 423_443 | 27 | 837.0 | Transmembrane | Helical |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 450_470 | 27 | 837.0 | Transmembrane | Helical |
| Hgene | TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 85_105 | 27 | 837.0 | Transmembrane | Helical |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 1349_1378 | 2851 | 4862.0 | Compositional bias | Note=Glu-rich | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 2002_2193 | 2851 | 4862.0 | Domain | B30.2/SPRY | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 371_420 | 2851 | 4862.0 | Repeat | Note=RCC1 1 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 421_475 | 2851 | 4862.0 | Repeat | Note=RCC1 2 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 476_528 | 2851 | 4862.0 | Repeat | Note=RCC1 3 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 529_578 | 2851 | 4862.0 | Repeat | Note=RCC1 4 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 580_631 | 2851 | 4862.0 | Repeat | Note=RCC1 5 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 633_682 | 2851 | 4862.0 | Repeat | Note=RCC1 6 | |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | 41 | 78 | 683_735 | 2851 | 4862.0 | Repeat | Note=RCC1 7 |
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Fusion Gene Sequence for TMTC2-HERC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >92513_92513_1_TMTC2-HERC1_TMTC2_chr12_83081448_ENST00000321196_HERC1_chr15_63956793_ENST00000443617_length(transcript)=7284nt_BP=790nt GTCACGCAGGCGCGGGGGGCCGCGTCGAGAACCCCACGCGGGAGCTTCTGGAGTCTCCAGCCACCGCTTCTCACTTCACTGGAGAAGGGA GCTGGGGCTGGGGCTGGGGCTGGGGCTGGGAGGGAGCTAATAAACATTGAATGTGCAGCAGCTGCCTTGGCGGCCGGAGTCCGCCCGAGC GACACCGGAGCAGTGCGCCCGGGAGGCGGCGAGGGGAGGCGGTTCGCCTTGTCCCTCCCACCCGCGCCTCTTTCTCTCTCTTCCTCCAGC TGGTCCCAGAGCCCGGCTTGGTCCGGTCCCTCTGCCCCCATCCCGCACCCTTCCACCTCCTCCGAGTCCCACTCCTCACCTAGGACGCCC CAAACTGCCATGGGTTAGGGTGGGGATCGCGACCCGCGCGAAAGACCAGCCCTGCGCTTCCGCCGGGGGACGCGGAGCCCAAACGCCGCT CACCGCTTGCGGGCGCCGGGCATGGGGAGTGTGGTGTGAGCCCGCACCCGGGGAGGACGCAGGAGCTGCGGAGACGGGCGCGAGGAGGAG GAGAGGAGTCGTGGATTGGAAGGACCCGAGGGAGGGAGGGTGGGGAAGCGAGGGAAAAGTGAAGCTGGGAGGAGAAGGCGGCGGAAGGTG GAGATTGATGCTTCTGTTTTTTGTTGCCGCTGCTGCCCTCGCGCTGGGAGCCGAGCCGGAGGGAAGGCGGTGGAGAGATGATTGCAGAGT TGGTGAGCAGCGCTCTGGGGCTCGCCTTGTATCTCAACACCCTGAGTGCGGATTTCTGCTATGATGACAGCCCTGATAATTTGGATCATA CAGAGAATGCAGCTTCTGGAAGTGGACCATCAGCTAGAGGTCGCTCAGCGGTAACAAGAAGACACAAGTTTGACTTAGCTGCTCGCACAC TGCTAGCAAGAGCAGCGGGATTATACCGCTCTGTGCAGGCCCACAGGAATCAAAGTCGGAGAGAAGGAATATCTTTGCAGCAAGACCCAG GGGCGTTGTATGACTTTAATTTAGATGAGGAATTGGAAATTGATCTTGATGATGAGGCGATGGAAGCTATGTTTGGACAAGACCTGACCA GTGACAATGATATTCTGGGAATGTGGATCCCAGAGGTACTGGATTGGCCTACCTGGCATGTTTGTGAGTCTGAAGACAGGGAAGAAGTGG TGGTGTGTGAACTGTGTGAATGCAGCGTCGTCAGCTTCAATCAGCACATGAAGAGAAACCATCCAGGCTGTGGGCGCAGTGCAAACCGCC AGGGCTATCGCAGCAATGGTTCCTATGTGGATGGCTGGTTTGGCGGTGAATGTGGGAGTGGAAATCCGTACTACCTGTTATGTGGCACCT GCAGGGAGAAGTACTTAGCCATGAAGACCAAATCTAAGTCAACAAGTTCTGAAAGGTACAAGGGACAAGCTCCAGATCTAATTGGCAAGC AAGACAGTGTGTATGAAGAAGACTGGGACATGTTGGATGTTGATGAAGATGAAAAGCTAACTGGTGAAGAAGAATTTGAATTACTTGCTG GACCGCTTGGTTTAAATGACCGGCGCATTGTACCAGAACCAGTTCAGTTCCCTGACAGCGATCCACTGGGAGCATCAGTAGCAATGGTCA CAGCCACCAACAGTATGGAAGAGACTCTGATGCAAATAGGTTGCCATGGCTCCGTAGAAAAGAGCTCCTCTGGGAGAATAACGTTAGGAG AGCAGGCAGCTGCCCTAGCAAACCCTCATGACCGTGTGGTGGCTTTAAGGAGAGTGACTGCTGCTGCTCAGGTTCTTCTGGCCAGAACCA TGGTCATGAGAGCGCTGTCTCTTCTCTCAGTCAGTGGTTCCAGTTGTAGCCTGGCTGCTGGTCTTGAGTCTCTGGGGCTAACAGATATCC GAACGCTAGTTCGATTAATGTGCTTGGCAGCAGCAGGGAGAGCTGGCCTCTCCACCAGCCCTTCTGCCATGGCTAGCACCTCAGAACGAT CACGAGGTGGGCATAGCAAGGCTAACAAGCCTATCTCTTGCCTGGCCTATTTGAGCACAGCAGTGGGATGTCTGGCATCAAATGCTCCTA GTGCTGCCAAACTGCTTGTACAGTTGTGTACACAGAACTTGATTTCTGCTGCAACAGGTGTAAATCTAACCACAGTTGATGACTCAATTC AGCGAAAGTTTCTACCCAGCTTTCTCCGAGGAATTGCTGAAGAGAACAAGCTTGTGACCTCCCCAAACTTTGTTGTAACACAGGCCCTTG TGGCATTGCTAGCAGACAAAGGGGCCAAACTAAGACCTAACTATGATAAGTCAGAAGTTGAAAAGAAAGGCCCTCTGGAGTTGGCTAATG CCCTGGCAGCCTGCTGCCTCTCCTCCAGGCTGTCCTCACAGCATCGGCAATGGGCAGCTCAGCAACTCGTGCGCACTCTTGCTGCACACG ACCGTGACAACCAAACTACTCTGCAGACACTTGCTGATATGGGAGGAGATCTTAGAAAATGCTCCTTTATCAAATTGGAGGCTCATCAGA ACAGAGTAATGACATGTGTTTGGTGTAATAAAAAAGGTCTTTTGGCTACAAGTGGCAATGATGGCACCATCCGCGTATGGAATGTTACCA AGAAGCAATATTCACTGCAACAGACCTGTGTGTTCAACAGATTGGAAGGGGATGCTGAGGAAAGCCTGGGATCACCCAGTGATCCAAGTT TCTCACCAGTTTCCTGGAGTATCAGTGGCAAATATCTAGCAGGCGCTTTGGAAAAGATGGTGAATATCTGGCAAGTTAATGGAGGAAAAG GATTAGTAGATATTCAGCCTCATTGGGTATCTGCCCTGGCTTGGCCAGAAGAGGGTCCGGCTACAGCCTGGTCAGGAGAGTCTCCAGAAT TGTTGTTGGTGGGACGGATGGATGGATCTCTGGGACTGATTGAAGTTGTTGATGTGTCCACCATGCACCGTCGAGAATTGGAGCATTGCT ATCGAAAGGATGTGTCTGTTACTTGCATTGCATGGTTCAGTGAAGACAGACCATTTGCAGTGGGATATTTTGATGGAAAACTGTTACTGG GAACAAAGGAACCACTTGAGAAAGGAGGCATTGTTCTAATTGATGCACATAAGGATACTCTTATTAGCATGAAGTGGGACCCTACAGGTC ATATTCTTATGACATGTGCCAAAGAAGACAGTGTGAAACTCTGGGGCTCTATTTCGGGATGCTGGTGCTGTCTACATTCACTCTGCCATC CATCTATTGTAAATGGCATTGCTTGGTGCCGCCTTCCAGGGAAAGGATCCAAGTTGCAGTTACTGATGGCTACTGGCTGTCAGAGTGGCT TAGTATGTGTTTGGCGCATTCCTCAAGATACTACACAGACCAATGTGACTAGTGCAGAAGGATGGTGGGAGCAGGAATCAAATTGCCAGG ATGGATATAGGAAATCATCAGGAGCCAAGTGTGTTTATCAGCTGCGGGGACACATCACTCCTGTTCGGACTGTTGCCTTTAGTTCTGATG GGTTGGCCCTGGTGTCTGGTGGACTAGGTGGGCTCATGAACATTTGGTCTTTAAGGGATGGCTCTGTCTTGCAAACTGTTGTGATAGGCT CTGGAGCTATTCAGACCACAGTATGGATTCCAGAAGTTGGAGTAGCTGCTTGCTCAAATAGATCAAAGGATGTTTTGGTCGTGAATTGTA CAGCAGAATGGGCAGCTGCCAATCATGTTTTGGCAACCTGTAGGACAGCATTGAAACAGCAGGGTGTTCTGGGATTGAACATGGCTCCCT GCATGAGAGCATTTTTGGAGCGGCTCCCCATGATGCTTCAGGAGCAGTATGCCTATGAAAAGCCTCATGTGGTTTGTGGTGACCAACTTG TTCATAGCCCCTATATGCAATGCTTGGCTTCCCTTGCTGTGGGACTTCATCTGGATCAGCTGTTGTGTAACCCTCCAGTGCCACCACACC ACCAGAACTGTCTCCCTGACCCTGCATCCTGGAATCCAAATGAATGGGCCTGGTTAGAATGTTTCTCAACCACTATAAAAGCTGCCGAAG CCCTGACCAATGGAGCCCAGTTTCCAGAATCTTTTACCGTTCCAGATCTAGAACCTGTTCCAGAGGATGAACTTGTATTTCTAATGGATA ACAGTAAATGGATTAACGGCATGGATGAACAAATTATGTCTTGGGCAACTTCCAGACCTGAGGACTGGCACCTGGGAGGTAAATGTGATG TCTACTTATGGGGTGCTGGTAGGCATGGACAGCTGGCAGAAGCTGGAAGAAATGTAATGGTACCTGCAGCAGCTCCCTCATTCTCACAGG CCCAACAGGTCATTTGTGGTCAGAATTGTACCTTTGTCATCCAGGCCAATGGCACAGTGTTGGCTTGTGGGGAAGGAAGTTATGGCAGAT TAGGACAAGGAAATTCAGATGACCTTCATGTGCTGACAGTTATTTCAGCCTTACAAGGCTTTGTGGTGACCCAGCTGGTGACTTCCTGTG GTTCTGATGGGCACTCTATGGCCCTAACTGAAAGTGGTGAGGTCTTTAGCTGGGGAGATGGTGACTATGGTAAACTTGGCCATGGGAACA GCGACAGGCAGCGGCGGCCCAGGCAGATCGAGGCCTTACAAGGAGAAGAAGTGGTGCAGATGTCTTGTGGCTTCAAGCACTCAGCAGTGG TCACTTCAGATGGCAAACTGTTCACCTTTGGGAATGGTGACTATGGTCGTCTGGGTCTTGGAAATACCTCTAACAAAAAACTTCCAGAGA GAGTGACTGCACTGGAGGGATATCAGATTGGACAGGTGGCCTGTGGATTAAACCACACTTTGGCAGTGTCAGCAGATGGTTCCATGGTGT GGGCTTTTGGAGATGGAGACTATGGAAAACTAGGCTTAGGAAATTCCACTGCAAAATCTTCACCTCAGAAAATTGACGTCCTTTGTGGAA TTGGAATAAAAAAGGTTGCTTGTGGAACTCAGTTTTCTGTTGCTTTGACCAAAGATGGTCATGTGTATACCTTTGGTCAAGATCGCCTGA TAGGCTTGCCAGAGGGGCGTGCTCGCAATCACAATCGACCGCAACAAATCCCTGTCCTGGCTGGAGTAATCATAGAAGATGTGGCAGTTG GAGCTGAACACACACTTGCTTTGGCATCAAATGGAGATGTGTATGCCTGGGGGAGCAATTCAGAAGGGCAGCTCGGCTTAGGCCATACCA ACCATGTTCGAGAACCAACCCTGGTAACAGGTCTGCAAGGGAAAAATGTTCGGCAGATCTCGGCTGGCCGCTGCCACAGTGCTGCATGGA CAGCACCACCTGTCCCACCAAGAGCACCAGGTGTGTCAGTACCTCTGCAGCTGGGCCTGCCTGACACAGTGCCCCCCCAGTATGGGGCGC TGAGAGAAGTCAGCATTCACACGGTGCGGGCCAGGCTCCGGCTGCTCTACCACTTCTCTGACCTCATGTACTCATCCTGGAGACTGCTGA ACCTTAGCCCCAACAACCAGAACAGCACATCCCATTATAATGCTGGAACTTGGGGCATTGTACAGGGACAACTTCGGCCTTTGTTAGCCC CAAGAGTCTACACTCTGCCAATGGTGCGCTCCATAGGAAAAACCATGGTTCAAGGCAAAAACTATGGACCTCAGATAACTGTAAAGAGGA TATCAACCAGAGGACGGAAGTGTAAGCCTATTTTTGTCCAAATAGCGAGACAAGTAGTTAAGCTGAATGCTTCAGACCTCCGCCTGCCTT CCCGAGCGTGGAAGGTTAAGCTGGTTGGAGAAGGGGCTGATGATGCTGGAGGAGTGTTTGATGACACCATCACAGAGATGTGCCAGGAAC TTGAAACTGGTATTGTTGACCTTCTTATACCCTCTCCCAATGCCACCGCAGAAGTGGGTTACAATAGGGACAGGTTCCTTTTTAACCCTT CTGCCTGCCTCGATGAACACTTAATGCAGTTTAAGTTTTTAGGAATTTTAATGGGGGTTGCCATTCGCACAAAGAAGCCTCTGGACCTCC ACTTGGCCCCTCTGGTGTGGAAGCAGCTGTGCTGTGTCCCACTCACCCTAGAGGACCTGGAGGAGGTGGATCTGCTCTACGTGCAGACTC TCAACAGCATTCTTCACATTGAAGACAGTGGGATTACCGAGGAGAGTTTCCATGAGATGATTCCTCTTGATTCTTTTGTTGGCCAGAGTG CTGATGGCAAAATGGTTCCTATAATCCCTGGTGGAAATAGTATCCCACTCACATTTTCCAACAGGAAGGAATATGTGGAGAGGGCCATTG AATATCGACTTCATGAGATGGACAGACAGGTGGCTGCAGTCCGAGAAGGGATGTCCTGGATTGTTCCTGTGCCGCTGCTGTCCCTCCTCA CAGCAAAACAACTGGAGCAGATGGTGTGTGGGATGCCCGAGATCTCTGTGGAAGTCTTGAAGAAAGTGGTGCGGTACCGTGAGGTGGATG AGCAGCATCAGCTGGTGCAGTGGTTCTGGCACACGCTGGAAGAGTTCTCCAATGAGGAGCGGGTGCTTTTCATGAGGTTTGTGTCAGGAA GATCTCGACTACCAGCCAACACTGCTGACATTTCTCAGAGATTTCAAATCATGAAGGTTGATAGGCCTTACGACAGTCTGCCTACCTCAC AGACCTGCTTCTTCCAGCTGAGGCTGCCCCCGTACTCCAGCCAGCTGGTCATGGCCGAGCGCCTGCGCTATGCCATCAACAACTGCCGCT CAATCGACATGGACAACTACATGCTCTCGAGAAACGTGGACAACGCCGAGGGCTCCGACACTGACTACTGACCGTGCGGGTGCTCTCACC CTCCCTTCTCTCCCTCAATAATGCTCACTTCTGATTTGATGTTGATATACTTTTATGGTAACTACATAGATGTTATAAGAACATAAACCA ACATTATAAACAATGGCCACATTTAGTTACTCTAAATGTAACAAAGAAATTAGATGTTTTTATTTTTCTGTGATTGTACAAAAACAACAA AAACGAAGTGCTCTCAGTCAGGTTTTTCCCTCCATATTTTTGGTCACTTTTGATAAGTTTGCATGAAACCATTTTGGTGCATTTTTAGTT GGGAATGGTACATTTTTGTAAATCCACCCAGTGAACATGAAATTGTACATTGTGTATAATTGTTCATTAGAAAGGACAGTTTTACATGAA >92513_92513_1_TMTC2-HERC1_TMTC2_chr12_83081448_ENST00000321196_HERC1_chr15_63956793_ENST00000443617_length(amino acids)=2056AA_BP=1229 MLPLLPSRWEPSRREGGGEMIAELVSSALGLALYLNTLSADFCYDDSPDNLDHTENAASGSGPSARGRSAVTRRHKFDLAARTLLARAAG LYRSVQAHRNQSRREGISLQQDPGALYDFNLDEELEIDLDDEAMEAMFGQDLTSDNDILGMWIPEVLDWPTWHVCESEDREEVVVCELCE CSVVSFNQHMKRNHPGCGRSANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKGQAPDLIGKQDSVYEE DWDMLDVDEDEKLTGEEEFELLAGPLGLNDRRIVPEPVQFPDSDPLGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRITLGEQAAALA NPHDRVVALRRVTAAAQVLLARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLSTSPSAMASTSERSRGGHSK ANKPISCLAYLSTAVGCLASNAPSAAKLLVQLCTQNLISAATGVNLTTVDDSIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADK GAKLRPNYDKSEVEKKGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTTLQTLADMGGDLRKCSFIKLEAHQNRVMTCV WCNKKGLLATSGNDGTIRVWNVTKKQYSLQQTCVFNRLEGDAEESLGSPSDPSFSPVSWSISGKYLAGALEKMVNIWQVNGGKGLVDIQP HWVSALAWPEEGPATAWSGESPELLLVGRMDGSLGLIEVVDVSTMHRRELEHCYRKDVSVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLE KGGIVLIDAHKDTLISMKWDPTGHILMTCAKEDSVKLWGSISGCWCCLHSLCHPSIVNGIAWCRLPGKGSKLQLLMATGCQSGLVCVWRI PQDTTQTNVTSAEGWWEQESNCQDGYRKSSGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTT VWIPEVGVAACSNRSKDVLVVNCTAEWAAANHVLATCRTALKQQGVLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQ CLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPDLEPVPEDELVFLMDNSKWING MDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSD DLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKL FTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVA CGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPT LVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDTVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQ NSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVK LVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVW KQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEM DRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPAN -------------------------------------------------------------- >92513_92513_2_TMTC2-HERC1_TMTC2_chr12_83081448_ENST00000548305_HERC1_chr15_63956793_ENST00000443617_length(transcript)=7163nt_BP=669nt GGGAGCTAATAAACATTGAATGTGCAGCAGCTGCCTTGGCGGCCGGAGTCCGCCCGAGCGACACCGGAGCAGTGCGCCCGGGAGGCGGCG AGGGGAGGCGGTTCGCCTTGTCCCTCCCACCCGCGCCTCTTTCTCTCTCTTCCTCCAGCTGGTCCCAGAGCCCGGCTTGGTCCGGTCCCT CTGCCCCCATCCCGCACCCTTCCACCTCCTCCGAGTCCCACTCCTCACCTAGGACGCCCCAAACTGCCATGGGTTAGGGTGGGGATCGCG ACCCGCGCGAAAGACCAGCCCTGCGCTTCCGCCGGGGGACGCGGAGCCCAAACGCCGCTCACCGCTTGCGGGCGCCGGGCATGGGGAGTG TGGTGTGAGCCCGCACCCGGGGAGGACGCAGGAGCTGCGGAGACGGGCGCGAGGAGGAGGAGAGGAGTCGTGGATTGGAAGGACCCGAGG GAGGGAGGGTGGGGAAGCGAGGGAAAAGTGAAGCTGGGAGGAGAAGGCGGCGGAAGGTGGAGATTGATGCTTCTGTTTTTTGTTGCCGCT GCTGCCCTCGCGCTGGGAGCCGAGCCGGAGGGAAGGCGGTGGAGAGATGATTGCAGAGTTGGTGAGCAGCGCTCTGGGGCTCGCCTTGTA TCTCAACACCCTGAGTGCGGATTTCTGCTATGATGACAGCCCTGATAATTTGGATCATACAGAGAATGCAGCTTCTGGAAGTGGACCATC AGCTAGAGGTCGCTCAGCGGTAACAAGAAGACACAAGTTTGACTTAGCTGCTCGCACACTGCTAGCAAGAGCAGCGGGATTATACCGCTC TGTGCAGGCCCACAGGAATCAAAGTCGGAGAGAAGGAATATCTTTGCAGCAAGACCCAGGGGCGTTGTATGACTTTAATTTAGATGAGGA ATTGGAAATTGATCTTGATGATGAGGCGATGGAAGCTATGTTTGGACAAGACCTGACCAGTGACAATGATATTCTGGGAATGTGGATCCC AGAGGTACTGGATTGGCCTACCTGGCATGTTTGTGAGTCTGAAGACAGGGAAGAAGTGGTGGTGTGTGAACTGTGTGAATGCAGCGTCGT CAGCTTCAATCAGCACATGAAGAGAAACCATCCAGGCTGTGGGCGCAGTGCAAACCGCCAGGGCTATCGCAGCAATGGTTCCTATGTGGA TGGCTGGTTTGGCGGTGAATGTGGGAGTGGAAATCCGTACTACCTGTTATGTGGCACCTGCAGGGAGAAGTACTTAGCCATGAAGACCAA ATCTAAGTCAACAAGTTCTGAAAGGTACAAGGGACAAGCTCCAGATCTAATTGGCAAGCAAGACAGTGTGTATGAAGAAGACTGGGACAT GTTGGATGTTGATGAAGATGAAAAGCTAACTGGTGAAGAAGAATTTGAATTACTTGCTGGACCGCTTGGTTTAAATGACCGGCGCATTGT ACCAGAACCAGTTCAGTTCCCTGACAGCGATCCACTGGGAGCATCAGTAGCAATGGTCACAGCCACCAACAGTATGGAAGAGACTCTGAT GCAAATAGGTTGCCATGGCTCCGTAGAAAAGAGCTCCTCTGGGAGAATAACGTTAGGAGAGCAGGCAGCTGCCCTAGCAAACCCTCATGA CCGTGTGGTGGCTTTAAGGAGAGTGACTGCTGCTGCTCAGGTTCTTCTGGCCAGAACCATGGTCATGAGAGCGCTGTCTCTTCTCTCAGT CAGTGGTTCCAGTTGTAGCCTGGCTGCTGGTCTTGAGTCTCTGGGGCTAACAGATATCCGAACGCTAGTTCGATTAATGTGCTTGGCAGC AGCAGGGAGAGCTGGCCTCTCCACCAGCCCTTCTGCCATGGCTAGCACCTCAGAACGATCACGAGGTGGGCATAGCAAGGCTAACAAGCC TATCTCTTGCCTGGCCTATTTGAGCACAGCAGTGGGATGTCTGGCATCAAATGCTCCTAGTGCTGCCAAACTGCTTGTACAGTTGTGTAC ACAGAACTTGATTTCTGCTGCAACAGGTGTAAATCTAACCACAGTTGATGACTCAATTCAGCGAAAGTTTCTACCCAGCTTTCTCCGAGG AATTGCTGAAGAGAACAAGCTTGTGACCTCCCCAAACTTTGTTGTAACACAGGCCCTTGTGGCATTGCTAGCAGACAAAGGGGCCAAACT AAGACCTAACTATGATAAGTCAGAAGTTGAAAAGAAAGGCCCTCTGGAGTTGGCTAATGCCCTGGCAGCCTGCTGCCTCTCCTCCAGGCT GTCCTCACAGCATCGGCAATGGGCAGCTCAGCAACTCGTGCGCACTCTTGCTGCACACGACCGTGACAACCAAACTACTCTGCAGACACT TGCTGATATGGGAGGAGATCTTAGAAAATGCTCCTTTATCAAATTGGAGGCTCATCAGAACAGAGTAATGACATGTGTTTGGTGTAATAA AAAAGGTCTTTTGGCTACAAGTGGCAATGATGGCACCATCCGCGTATGGAATGTTACCAAGAAGCAATATTCACTGCAACAGACCTGTGT GTTCAACAGATTGGAAGGGGATGCTGAGGAAAGCCTGGGATCACCCAGTGATCCAAGTTTCTCACCAGTTTCCTGGAGTATCAGTGGCAA ATATCTAGCAGGCGCTTTGGAAAAGATGGTGAATATCTGGCAAGTTAATGGAGGAAAAGGATTAGTAGATATTCAGCCTCATTGGGTATC TGCCCTGGCTTGGCCAGAAGAGGGTCCGGCTACAGCCTGGTCAGGAGAGTCTCCAGAATTGTTGTTGGTGGGACGGATGGATGGATCTCT GGGACTGATTGAAGTTGTTGATGTGTCCACCATGCACCGTCGAGAATTGGAGCATTGCTATCGAAAGGATGTGTCTGTTACTTGCATTGC ATGGTTCAGTGAAGACAGACCATTTGCAGTGGGATATTTTGATGGAAAACTGTTACTGGGAACAAAGGAACCACTTGAGAAAGGAGGCAT TGTTCTAATTGATGCACATAAGGATACTCTTATTAGCATGAAGTGGGACCCTACAGGTCATATTCTTATGACATGTGCCAAAGAAGACAG TGTGAAACTCTGGGGCTCTATTTCGGGATGCTGGTGCTGTCTACATTCACTCTGCCATCCATCTATTGTAAATGGCATTGCTTGGTGCCG CCTTCCAGGGAAAGGATCCAAGTTGCAGTTACTGATGGCTACTGGCTGTCAGAGTGGCTTAGTATGTGTTTGGCGCATTCCTCAAGATAC TACACAGACCAATGTGACTAGTGCAGAAGGATGGTGGGAGCAGGAATCAAATTGCCAGGATGGATATAGGAAATCATCAGGAGCCAAGTG TGTTTATCAGCTGCGGGGACACATCACTCCTGTTCGGACTGTTGCCTTTAGTTCTGATGGGTTGGCCCTGGTGTCTGGTGGACTAGGTGG GCTCATGAACATTTGGTCTTTAAGGGATGGCTCTGTCTTGCAAACTGTTGTGATAGGCTCTGGAGCTATTCAGACCACAGTATGGATTCC AGAAGTTGGAGTAGCTGCTTGCTCAAATAGATCAAAGGATGTTTTGGTCGTGAATTGTACAGCAGAATGGGCAGCTGCCAATCATGTTTT GGCAACCTGTAGGACAGCATTGAAACAGCAGGGTGTTCTGGGATTGAACATGGCTCCCTGCATGAGAGCATTTTTGGAGCGGCTCCCCAT GATGCTTCAGGAGCAGTATGCCTATGAAAAGCCTCATGTGGTTTGTGGTGACCAACTTGTTCATAGCCCCTATATGCAATGCTTGGCTTC CCTTGCTGTGGGACTTCATCTGGATCAGCTGTTGTGTAACCCTCCAGTGCCACCACACCACCAGAACTGTCTCCCTGACCCTGCATCCTG GAATCCAAATGAATGGGCCTGGTTAGAATGTTTCTCAACCACTATAAAAGCTGCCGAAGCCCTGACCAATGGAGCCCAGTTTCCAGAATC TTTTACCGTTCCAGATCTAGAACCTGTTCCAGAGGATGAACTTGTATTTCTAATGGATAACAGTAAATGGATTAACGGCATGGATGAACA AATTATGTCTTGGGCAACTTCCAGACCTGAGGACTGGCACCTGGGAGGTAAATGTGATGTCTACTTATGGGGTGCTGGTAGGCATGGACA GCTGGCAGAAGCTGGAAGAAATGTAATGGTACCTGCAGCAGCTCCCTCATTCTCACAGGCCCAACAGGTCATTTGTGGTCAGAATTGTAC CTTTGTCATCCAGGCCAATGGCACAGTGTTGGCTTGTGGGGAAGGAAGTTATGGCAGATTAGGACAAGGAAATTCAGATGACCTTCATGT GCTGACAGTTATTTCAGCCTTACAAGGCTTTGTGGTGACCCAGCTGGTGACTTCCTGTGGTTCTGATGGGCACTCTATGGCCCTAACTGA AAGTGGTGAGGTCTTTAGCTGGGGAGATGGTGACTATGGTAAACTTGGCCATGGGAACAGCGACAGGCAGCGGCGGCCCAGGCAGATCGA GGCCTTACAAGGAGAAGAAGTGGTGCAGATGTCTTGTGGCTTCAAGCACTCAGCAGTGGTCACTTCAGATGGCAAACTGTTCACCTTTGG GAATGGTGACTATGGTCGTCTGGGTCTTGGAAATACCTCTAACAAAAAACTTCCAGAGAGAGTGACTGCACTGGAGGGATATCAGATTGG ACAGGTGGCCTGTGGATTAAACCACACTTTGGCAGTGTCAGCAGATGGTTCCATGGTGTGGGCTTTTGGAGATGGAGACTATGGAAAACT AGGCTTAGGAAATTCCACTGCAAAATCTTCACCTCAGAAAATTGACGTCCTTTGTGGAATTGGAATAAAAAAGGTTGCTTGTGGAACTCA GTTTTCTGTTGCTTTGACCAAAGATGGTCATGTGTATACCTTTGGTCAAGATCGCCTGATAGGCTTGCCAGAGGGGCGTGCTCGCAATCA CAATCGACCGCAACAAATCCCTGTCCTGGCTGGAGTAATCATAGAAGATGTGGCAGTTGGAGCTGAACACACACTTGCTTTGGCATCAAA TGGAGATGTGTATGCCTGGGGGAGCAATTCAGAAGGGCAGCTCGGCTTAGGCCATACCAACCATGTTCGAGAACCAACCCTGGTAACAGG TCTGCAAGGGAAAAATGTTCGGCAGATCTCGGCTGGCCGCTGCCACAGTGCTGCATGGACAGCACCACCTGTCCCACCAAGAGCACCAGG TGTGTCAGTACCTCTGCAGCTGGGCCTGCCTGACACAGTGCCCCCCCAGTATGGGGCGCTGAGAGAAGTCAGCATTCACACGGTGCGGGC CAGGCTCCGGCTGCTCTACCACTTCTCTGACCTCATGTACTCATCCTGGAGACTGCTGAACCTTAGCCCCAACAACCAGAACAGCACATC CCATTATAATGCTGGAACTTGGGGCATTGTACAGGGACAACTTCGGCCTTTGTTAGCCCCAAGAGTCTACACTCTGCCAATGGTGCGCTC CATAGGAAAAACCATGGTTCAAGGCAAAAACTATGGACCTCAGATAACTGTAAAGAGGATATCAACCAGAGGACGGAAGTGTAAGCCTAT TTTTGTCCAAATAGCGAGACAAGTAGTTAAGCTGAATGCTTCAGACCTCCGCCTGCCTTCCCGAGCGTGGAAGGTTAAGCTGGTTGGAGA AGGGGCTGATGATGCTGGAGGAGTGTTTGATGACACCATCACAGAGATGTGCCAGGAACTTGAAACTGGTATTGTTGACCTTCTTATACC CTCTCCCAATGCCACCGCAGAAGTGGGTTACAATAGGGACAGGTTCCTTTTTAACCCTTCTGCCTGCCTCGATGAACACTTAATGCAGTT TAAGTTTTTAGGAATTTTAATGGGGGTTGCCATTCGCACAAAGAAGCCTCTGGACCTCCACTTGGCCCCTCTGGTGTGGAAGCAGCTGTG CTGTGTCCCACTCACCCTAGAGGACCTGGAGGAGGTGGATCTGCTCTACGTGCAGACTCTCAACAGCATTCTTCACATTGAAGACAGTGG GATTACCGAGGAGAGTTTCCATGAGATGATTCCTCTTGATTCTTTTGTTGGCCAGAGTGCTGATGGCAAAATGGTTCCTATAATCCCTGG TGGAAATAGTATCCCACTCACATTTTCCAACAGGAAGGAATATGTGGAGAGGGCCATTGAATATCGACTTCATGAGATGGACAGACAGGT GGCTGCAGTCCGAGAAGGGATGTCCTGGATTGTTCCTGTGCCGCTGCTGTCCCTCCTCACAGCAAAACAACTGGAGCAGATGGTGTGTGG GATGCCCGAGATCTCTGTGGAAGTCTTGAAGAAAGTGGTGCGGTACCGTGAGGTGGATGAGCAGCATCAGCTGGTGCAGTGGTTCTGGCA CACGCTGGAAGAGTTCTCCAATGAGGAGCGGGTGCTTTTCATGAGGTTTGTGTCAGGAAGATCTCGACTACCAGCCAACACTGCTGACAT TTCTCAGAGATTTCAAATCATGAAGGTTGATAGGCCTTACGACAGTCTGCCTACCTCACAGACCTGCTTCTTCCAGCTGAGGCTGCCCCC GTACTCCAGCCAGCTGGTCATGGCCGAGCGCCTGCGCTATGCCATCAACAACTGCCGCTCAATCGACATGGACAACTACATGCTCTCGAG AAACGTGGACAACGCCGAGGGCTCCGACACTGACTACTGACCGTGCGGGTGCTCTCACCCTCCCTTCTCTCCCTCAATAATGCTCACTTC TGATTTGATGTTGATATACTTTTATGGTAACTACATAGATGTTATAAGAACATAAACCAACATTATAAACAATGGCCACATTTAGTTACT CTAAATGTAACAAAGAAATTAGATGTTTTTATTTTTCTGTGATTGTACAAAAACAACAAAAACGAAGTGCTCTCAGTCAGGTTTTTCCCT CCATATTTTTGGTCACTTTTGATAAGTTTGCATGAAACCATTTTGGTGCATTTTTAGTTGGGAATGGTACATTTTTGTAAATCCACCCAG TGAACATGAAATTGTACATTGTGTATAATTGTTCATTAGAAAGGACAGTTTTACATGAATATTCATATATTTATTTTGTTTTAATTTGAA >92513_92513_2_TMTC2-HERC1_TMTC2_chr12_83081448_ENST00000548305_HERC1_chr15_63956793_ENST00000443617_length(amino acids)=2056AA_BP=1229 MLPLLPSRWEPSRREGGGEMIAELVSSALGLALYLNTLSADFCYDDSPDNLDHTENAASGSGPSARGRSAVTRRHKFDLAARTLLARAAG LYRSVQAHRNQSRREGISLQQDPGALYDFNLDEELEIDLDDEAMEAMFGQDLTSDNDILGMWIPEVLDWPTWHVCESEDREEVVVCELCE CSVVSFNQHMKRNHPGCGRSANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKGQAPDLIGKQDSVYEE DWDMLDVDEDEKLTGEEEFELLAGPLGLNDRRIVPEPVQFPDSDPLGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRITLGEQAAALA NPHDRVVALRRVTAAAQVLLARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLSTSPSAMASTSERSRGGHSK ANKPISCLAYLSTAVGCLASNAPSAAKLLVQLCTQNLISAATGVNLTTVDDSIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADK GAKLRPNYDKSEVEKKGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTTLQTLADMGGDLRKCSFIKLEAHQNRVMTCV WCNKKGLLATSGNDGTIRVWNVTKKQYSLQQTCVFNRLEGDAEESLGSPSDPSFSPVSWSISGKYLAGALEKMVNIWQVNGGKGLVDIQP HWVSALAWPEEGPATAWSGESPELLLVGRMDGSLGLIEVVDVSTMHRRELEHCYRKDVSVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLE KGGIVLIDAHKDTLISMKWDPTGHILMTCAKEDSVKLWGSISGCWCCLHSLCHPSIVNGIAWCRLPGKGSKLQLLMATGCQSGLVCVWRI PQDTTQTNVTSAEGWWEQESNCQDGYRKSSGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTT VWIPEVGVAACSNRSKDVLVVNCTAEWAAANHVLATCRTALKQQGVLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQ CLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPDLEPVPEDELVFLMDNSKWING MDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSD DLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKL FTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVA CGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPT LVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDTVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQ NSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVK LVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVW KQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEM DRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPAN -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TMTC2-HERC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TMTC2-HERC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TMTC2-HERC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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