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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TNFAIP8-DMXL1 (FusionGDB2 ID:92605)

Fusion Gene Summary for TNFAIP8-DMXL1

check button Fusion gene summary
Fusion gene informationFusion gene name: TNFAIP8-DMXL1
Fusion gene ID: 92605
HgeneTgene
Gene symbol

TNFAIP8

DMXL1

Gene ID

25816

1657

Gene nameTNF alpha induced protein 8Dmx like 1
SynonymsGG2-1|MDC-3.13|NDED|SCC-S2|SCCS2-
Cytomap

5q23.1

5q23.1

Type of geneprotein-codingprotein-coding
Descriptiontumor necrosis factor alpha-induced protein 8NF-kappa-B-inducible DED-containing proteinTNF-induced protein GG2-1head and neck tumor and metastasis-related proteintumor necrosis factor, alpha induced protein 8dmX-like protein 1
Modification date2020031320200313
UniProtAcc.

Q9Y485

Ensembl transtripts involved in fusion geneENST00000274456, ENST00000415806, 
ENST00000503646, ENST00000504642, 
ENST00000504771, ENST00000513374, 
ENST00000505312, ENST00000311085, 
ENST00000539542, 
Fusion gene scores* DoF score8 X 5 X 8=3204 X 5 X 4=80
# samples 115
** MAII scorelog2(11/320*10)=-1.5405683813627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNFAIP8 [Title/Abstract] AND DMXL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDMXL1(118452031)-TNFAIP8(118728510), # samples:2
DMXL1(118569162)-TNFAIP8(118728510), # samples:2
TNFAIP8(118604602)-DMXL1(118464906), # samples:1
TNFAIP8(118604602)-DMXL1(118576114), # samples:1
Anticipated loss of major functional domain due to fusion event.DMXL1-TNFAIP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TNFAIP8-DMXL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TNFAIP8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DMXL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-A9ST-01ATNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
ChimerDB4PCPGTCGA-WB-A81S-01ATNFAIP8chr5

118604602

-DMXL1chr5

118464906

+


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Fusion Gene ORF analysis for TNFAIP8-DMXL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000274456ENST00000505312TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
5CDS-intronENST00000274456ENST00000505312TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
Frame-shiftENST00000274456ENST00000311085TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
Frame-shiftENST00000274456ENST00000539542TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
In-frameENST00000274456ENST00000311085TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
In-frameENST00000274456ENST00000539542TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-3CDSENST00000415806ENST00000311085TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-3CDSENST00000415806ENST00000311085TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-3CDSENST00000415806ENST00000539542TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-3CDSENST00000415806ENST00000539542TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-3CDSENST00000503646ENST00000311085TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-3CDSENST00000503646ENST00000311085TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-3CDSENST00000503646ENST00000539542TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-3CDSENST00000503646ENST00000539542TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-3CDSENST00000504642ENST00000311085TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-3CDSENST00000504642ENST00000311085TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-3CDSENST00000504642ENST00000539542TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-3CDSENST00000504642ENST00000539542TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-3CDSENST00000504771ENST00000311085TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-3CDSENST00000504771ENST00000311085TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-3CDSENST00000504771ENST00000539542TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-3CDSENST00000504771ENST00000539542TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-3CDSENST00000513374ENST00000311085TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-3CDSENST00000513374ENST00000311085TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-3CDSENST00000513374ENST00000539542TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-3CDSENST00000513374ENST00000539542TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-3UTRENST00000415806ENST00000505312TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-3UTRENST00000503646ENST00000505312TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-3UTRENST00000504642ENST00000505312TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-3UTRENST00000504771ENST00000505312TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-3UTRENST00000513374ENST00000505312TNFAIP8chr5

118604602

-DMXL1chr5

118576114

+
intron-intronENST00000415806ENST00000505312TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-intronENST00000503646ENST00000505312TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-intronENST00000504642ENST00000505312TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-intronENST00000504771ENST00000505312TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+
intron-intronENST00000513374ENST00000505312TNFAIP8chr5

118604602

-DMXL1chr5

118464906

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000274456TNFAIP8chr5118604602-ENST00000311085DMXL1chr5118464906+1010621624581972650
ENST00000274456TNFAIP8chr5118604602-ENST00000539542DMXL1chr5118464906+840721624582602671

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000274456ENST00000311085TNFAIP8chr5118604602-DMXL1chr5118464906+0.0001961330.99980384
ENST00000274456ENST00000539542TNFAIP8chr5118604602-DMXL1chr5118464906+0.0007024010.9992976

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Fusion Genomic Features for TNFAIP8-DMXL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TNFAIP8-DMXL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:118452031/chr5:118728510)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DMXL1

Q9Y485

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDMXL1chr5:118604602chr5:118464906ENST000003110858432459_24683673028.0Compositional biasNote=Poly-Asp
TgeneDMXL1chr5:118604602chr5:118464906ENST000003110858431134_11753673028.0RepeatNote=WD 9
TgeneDMXL1chr5:118604602chr5:118464906ENST000003110858431211_12513673028.0RepeatNote=WD 10
TgeneDMXL1chr5:118604602chr5:118464906ENST000003110858432742_27833673028.0RepeatNote=WD 11
TgeneDMXL1chr5:118604602chr5:118464906ENST000003110858432785_28243673028.0RepeatNote=WD 12
TgeneDMXL1chr5:118604602chr5:118464906ENST000003110858432836_28783673028.0RepeatNote=WD 12
TgeneDMXL1chr5:118604602chr5:118464906ENST000003110858432884_29233673028.0RepeatNote=WD 14
TgeneDMXL1chr5:118604602chr5:118464906ENST000003110858432926_29653673028.0RepeatNote=WD 15
TgeneDMXL1chr5:118604602chr5:118464906ENST000003110858432978_30163673028.0RepeatNote=WD 16
TgeneDMXL1chr5:118604602chr5:118464906ENST00000311085843476_5163673028.0RepeatNote=WD 4
TgeneDMXL1chr5:118604602chr5:118464906ENST00000311085843580_6213673028.0RepeatNote=WD 5
TgeneDMXL1chr5:118604602chr5:118464906ENST00000311085843628_6653673028.0RepeatNote=WD 6
TgeneDMXL1chr5:118604602chr5:118464906ENST00000311085843848_8953673028.0RepeatNote=WD 7
TgeneDMXL1chr5:118604602chr5:118464906ENST00000311085843968_10103673028.0RepeatNote=WD 8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNFAIP8chr5:118604602chr5:118464906ENST00000274456-1249_830189.0Coiled coilOntology_term=ECO:0000255
HgeneTNFAIP8chr5:118604602chr5:118464906ENST00000503646-1349_830199.0Coiled coilOntology_term=ECO:0000255
HgeneTNFAIP8chr5:118604602chr5:118464906ENST00000504771-1249_830199.0Coiled coilOntology_term=ECO:0000255
TgeneDMXL1chr5:118604602chr5:118464906ENST00000311085843108_1453673028.0RepeatNote=WD 1
TgeneDMXL1chr5:118604602chr5:118464906ENST00000311085843166_2063673028.0RepeatNote=WD 2
TgeneDMXL1chr5:118604602chr5:118464906ENST00000311085843229_2773673028.0RepeatNote=WD 3


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Fusion Gene Sequence for TNFAIP8-DMXL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92605_92605_1_TNFAIP8-DMXL1_TNFAIP8_chr5_118604602_ENST00000274456_DMXL1_chr5_118464906_ENST00000311085_length(transcript)=10106nt_BP=216nt
GACCTCCCGGCTCCTCCCCGGCCTGCCCGCCACACCCTTGGTCCCTCCTGCAAGTTCCGCCCCTGGCCTCTGCCTCCTTTTCTCCCGCCG
GCTCTAACCCGCGCTTGGCTAAGGTCCGCGGGAACCCGTGAGCCACCGAGAGAGCAGAGAACTCGGCGCCGCCAAACAGCCCAGCTCGCG
CTTCAGCGTCCCGGCGCCGTCGCGCCACTCCTCCGAACATTCCACTTCTTCCATCTATTACATCTCTGAGTCTAAATGAAAATGAAGAGA
AGACCGGACCTTTTGTTGTACACTGGCTAAACAATAAAGAACTGCATTTTACTTTGTCCATGGAAGTTTTTTTACAGCAACTTAGAAAAA
GTTTTGAACAACCATCTTCTGAGGCCAGTGTAGAAGATTCTAATCAGGCAGATGTAAAATCTGATGAAGAAACTGATGATGGTGTTGATG
ATCTGAAAATAAATCCCGAAAAGAAGGAATTAGGCTGTGATAAAATGGTACCAAACTCAAGTTTTACATCATTATCGTCAGCTGCCATTG
ATCATCAGATTGAAGTACTTCTGTCTGAATGGAGTAAAAATGCAGATATGCTATTTAGTATTCATCCCATGGATGGTTCTTTGCTAGTTT
GGCATGTGGATTGGCTGGATGAATACCAGCCTGGTATGTTTCGTCAAGTACAGGTGTCCTTTGTTTCCAGAATTCCAGTAGCTTTCCCCA
CAGGTGATGCAAACTCTCTCTGTAAAAGCATAATGATGTATGCCTGTACCAAGAATGTTGACTTGGCTATTCAGCAGGGGAAACAAAAAC
CTTCTGGCCTCACCCGTTCCACATCAATGCTTATTTCTTCTGGTCACAATAAATCATCTAATAGTTTAAAATTAAGTATTTTTACGCCTA
ATGTTATGATGATATCAAAACATGCTGATGGTTCTCTGAATCAGTGGCTGGTCAGTTTTGCCGAGGAATCTGCTTTTTCTACTGTTCTCA
GTATTTCCCACAAATCCAGATATTGTGGTCATCGTTTTCATCTTAATGATTTAGCTTGCCACTCAGTATTACCATTATTGCTGACAACAT
CACACCATAATGCATTAAGGACACCAGATGTTGATAACCCAGAGCAACCTTTTGATGCTCTAAATATTGAAGAATGCTCTTTGACACAAC
AAAATAAAAGCACTGTTGACGTGGCATTTCAGGATCCCAGTGCAGTTTACAGTGAGCTTATTCTGTGGAGGGTTGACCCAGTTGGGCCAT
TGTCTTTTTCTGGAGGAGTTTCTGAGCTTGCCCGGATTAATTCTCTTCATGTTTCTGCCTTTTCCAATGTGGCATGGCTGCCCACTCTTA
TACCCAGTTATTGTCTGGGTGCATACTGCAACTCTCCTAGTGCATGCTTTGTAGCCAGTGATGGACAATATCTGAGATTATATGAAGCAG
TTATTGATGCTAAGAAACTTTTATCTGAGCTTTCTAACCCTGAAATTTCTAAATATGTTGGTGAAGTCTTTAACATCGTCAGTCAACAAT
CAACAGCCAGGCCAGGATGCATTATTGCATTAGATCCCATTACCAAACTTCATGGCAGAAAAACCCAACTGCTTCATGTTTTTGAAGAAG
ACTTCATTTTGAATAACCTTGAGAAGAAAAGCCTTGGCAAAGACAGCATTTTATCTAATGCAGGCAGCTCACCTAATGGATTTTCTGAGA
AGTTCTACCTAATTGTAATAGAATGCACTCAAGACAACCGTTCACTGTTACACATGTGGAATTTACATCTAAAGTCAATTCCTGTCTCAT
TAGATGAAAAAGTAGATACAAAATTATCCGAAGCGGTTTGGCAGCCAGAAGAACATTATTCTTCTTCTCCAGAGAAGATCCTATCTCCTT
TTTCACAAAAGTATCAGGCTTGCAGAGCAAATCTCCAGAGTACCAGCAGGTTGACTCTGTTTTCAGAAATGGTTTATAGCCAAGAATTGC
ATTTACCAGAAGGAGTTGAGATAATAAGTATTAAGCCATCAGCAGGACATCTGAGTTCATCTTCTATATATCCTGCATGCAGTGCTCCTT
ATTTATTGGCAACTTCATGTTCAGATGAGAAAGTAAGATTCTGGAGATGCAGAGTAACAGATGGAGAATCTGCCACGTCAAAGAATGGAA
AAATTGATCTTGCATACATTTGGGAAGAATGGCCATTACTTATTGAAGATGGACTTCAGAGCAATAGTAGTATAACTGTACCTGGTAGGC
CTGTAGAAGTTAGCTGTGCACATACAAATCGTTTAGCAGTAGCTTATAAGCAGCCTGCATCTAATAGTAGATCTTCCCAGGACTTTGTGA
TGCATGTAAGTATTTTTGAATGTGAGTCAACAGGAGGTTCATGTTGGGTCCTTGAGCAGACAATTCATTTAGATGAGTTAAGCACAGTAT
TGGATTCTGGCATTAGTGTTGATAGCAATTTAGTGGCCTATAATAAACAAGACATGTATTTATCTAGTAAAGAGAATATCACATCAAACA
CAAAGCATTTAGTTCACTTAGATTGGATGTCTAGAGAAGACGGTTCTCATATCCTGACTGTAGGAATTGGATCAAAACTTTTTATGTATG
GACCCCTGGCTGGCAAGGTACAAGACCAAACTGGTAAGGAAACCCTGGCATTTCCTCTCTGGGAGAGTACCAAAGTTGTGCCCCTTTCTA
AATTTGTACTATTACGAAGTGTGGACCTAGTTTCTTCTGTAGATGGCTCCCCACCTTTTCCTGTTTCTTTATCGTGGGTCCGGGATGGCA
TCCTTGTGGTAGGAATGGACTGTGAAATGCATGTGTATTGCCAATGGCAACCATCTTCTAAACAAGAACCTGTTATAACAGATTCGTACA
GTGGGAGCACTCCATCTATAACAAGTTTAATAAAACAGAGTAACTCCAGTTCTGGGTTACATCCTCCAAAGAAAACTCTGACTCGATCCA
TGACCAGTCTTGCACAGAAAATCTGTGGAAAGAAAACTGCATTCGATCCTTCAGTGGATATGGAAGATTCAGGTCTTTTTGAAGCAGCTC
ATGTACTTTCCCCGACTCTACCTCAGTATCATCCCTTGCAGCTTTTGGAACTCATGGATCTTGGTAAAGTTCGGAGAGCCAAGGCCATCT
TGTCCCATCTTGTTAAGTGCATTGCTGGGGAAGTTGTGGCTCTGAATGAAGCTGAATCTAATCATGAACGCCGCCTTAGGTCTCTCACAA
TCAGTGCTAGTGGAAGCACTACCAGAGACCCCCAGGCATTCAACAAGGCTGAAAATACAGATTACACAGAAATAGATTCTGTTCCTCCAC
TTCCTTTATATGCCTTACTTGCAGCAGATGATGATAGCTGTTACTCATCTTTGGAGAAATCTAGTAATGAGAGTACGTTAAGTAAATCAA
ACCAATTATCTAAAGAAAGTTATGATGAGCTTTTTCAGACTCAACTTCTAATGACTGATACTCATATGTTAGAGACAGATGAAGAAAATA
CAAAGCCTAGAGTTATTGACCTTTCACAGTACAGTCCGACTTACTTTGGACCTGAGCATGCTCAGGTTCTTTCTGGCCACTTACTTCATT
CTAGTTTACCAGGACTCAGCCGGATGGAGCAGATGTCTTTGATGGCCTTAGCAGATACAATTGCAACTACAAGCACTGATATTGGAGAAA
GCCGAGACAGAAGCCAAGGTGGAGAAACTCTTGATGAATGTGGGTTAAAATTTCTTTTGGCTGTTCGACTCCATACCTTTCTTACAACTT
CCCTTCCAGCCTATCGAGCTCAACTCCTTCACCAAGGCCTGTCTACAAGTCATTTTGCTTGGGCATTTCACTCAGTAGCAGAAGAAGAAC
TGCTGAACATGTTGCCAGCCATGCAGAAAGATGATCCCACTTGGTCTGAACTAAGAGCTATGGGTGTGGGGTGGTGGGTCCGGAATACCC
GCATCTTACGCAAATGCATAGAAAAAGTAGCTAAAGCAGCCTTTTATAGAAAGAATGATCCTTTAGATGCTGCCATTTTTTACCTTGCAA
TGAAAAAGAAAGCTGTGATTTGGGGATTATATAGAGCTGAAAAAAACACCAGGATGACACAGTTTTTTGGACACAATTTTGAGGATGAGA
GGTGGCGTAAAGCAGCTTTAAAGAATGCTTTTTCTTTGCTAGGCAAACAAAGATTTGAACATTCTGCAGCATTTTTTCTTTTAGCTGGTT
GCCTCAGAGATGCAATTGAGGTATGTCTTGAGAAATTGAATGACATTCAGTTGGCTCTTGTAATAGCAAGACTCTATGAGTCTGAATTTG
ATACATCTGCAGCATATAAATCTATTTTACGTAAAAAAGTTTTGGGAATCGATTCTCCTGTCAGTGAACTGTGTTCATTGAACATAAATA
TGCATCATGATCCTTTTCTTCGGAGCATGGCATATTGGATTTTGGAAGATTATAGTGGTGCTCTGGAAACATTAATAAAGCAACCTATCA
GAGAGAATGATGATCAAGTTTTATCAGCCAGTAATCCTACAGTTTTTAATTTCTACAATTATCTAAGAACACATCCTCTTTTGCTGAGAC
GTCATTTTGGATCATCTGATACATTTTCCACACATATGAGCCTAACAGGAAAAAGTGGACTGGCAGGAACAATTAATTTAAGTGAAAGAC
GTTTATTTTTTACCACTGCCAGTGCTCATTTAAAAGCTGGCTGCCCAATGTTGGCTTTGGAAGTATTATCAAAGATGCCTAAAGTCATCA
AGAAAACAAGACCTTTTTATAGGGCTTCTAGTTTTCTGGATACTAGTAAAGACTGTTCTCCTTCTTCTCCATTAAAGTTGGATGCAAGGG
AAGATAAGTCTTCTGCTGTTGATTGGTCACAGTCACTGATAAATGGTTTTGGATCTTCTTCAGAGGGTTCCTCAGAGAAGCAATCAAACT
CCACTCTTTCTTTTGACTGGAGCCAACCAAGTGTTGTGTTTCAGGATGACTCTTTAGAGTTAAAATGGGACAGTGATAATGATGAAGAAA
ATGAGGATGTCCCTATTTCAATGAAAGAACTAAAACCTTTACAGAGAAAAACAGATAAAAAGTTGGATGACATAAGTTCTAACTACACAG
AATCTTTCAGCACACTAGATGAAAATGACCTTTTAAATCCATCAGAAGATATAATTGCAGTTCAGTTAAAATTTAGAGCATGTTTAAAGA
TTCTCACAGTAGAACTTCGTACTTTATCTACTGGCTATGAAATAGATGGTGGAAAATTGCGTTACCAACTATACCACTGGCTTGAAAAAG
AGGTGATAGCTCTTCAGAGGACTTGTGACTTTTGCTCAGATGCTGAAGAACTACAGTCTGCATTTGGCAGAAATGAAGATGAATTTGGAT
TAAATGAGGATGCTGAAGATTTGCCTCACCAAACAAAAGTGAAACAACTGAGAGAAAATTTTCAGGAAAAAAGACAGTGGCTCTTGAAGT
ATCAGTCACTTTTGAGAATGTTTCTTAGTTACTGCATACTTCATGGATCCCATGGTGGGGGTCTTGCATCTGTAAGAATGGAATTGATTT
TGCTTTTGCAAGAATCTCAGCAGGAAACATCAGAACCACTATTTTCTAGCCCTCTGTCAGAGCAAACCTCAGTGCCTCTCCTCTTTGCTT
GTACAGCCAATGCCAAAACAGTAGTTGCCAATCCATTATTGCACCTTAGTAATCTGACACATGATATTCTCCATGCCATAATAAACTTTG
ATTCACCACCCCACCCTGATATCCAAAGCAATAAAGTGTATGTAATGCATACTTTAGCAGCTTCACTTTCTGCTTGTATTTATCAGTGCC
TTTGTGGTAGTCATAACTACAGTTCATTTCAGACGAATCAGTTTACTGGAATGGTATATCAGACAGTACTGCTTCCTCATCGACCTTCTT
TGAAAACAGGAAGCTTAGATGAAGCATTAACTCCCAATACGTCACCAGCTCAATGGCCAGGAATAACTTGTCTAATTCGACTTTTGAATT
CTTCTGGCGAGGAAGCCCAGTCAGGGCTTACAGTCTTGCTCTGTGAGATTCTCACAGCAGTGTATCTTAGTCTCTTCATCCATGGCCTGG
CCACACATTCAAGTAATGAGCTATTTCGGATTGTGGCCCATCCTCTAAATGAGAAAATGTGGTCTGCTGTGTTTGGTGGAGGTGCACATG
TTCCTAGCAAAGAACAGACACATTCAAAAACTTTACCTGTTTCTTCACTAGTTGAAGAAGGAGAAAAACAGAACAAACGTTTTAGGCCGT
CAAAAATGTCTTGCAGAGAATCTGCCCCACTGACCCCTTCCTCGGCACCAGTAAGCCAGGAGTCACTGGCGGTTAAAGAAAAGTTCATCC
CACCTGAGCTCAGTATCTGGGACTATTTCATAGCTAAGCCTTTTCTACCCTCTTCTCAAAGTAGAGCCGAATATGATTCAGAGGAGAGTC
TGGGAAGTGATGATGATGACAATGATGATGATGATGATGTTTTAGCATCAGATTTCCATCTCCAGGAACATTCTAATTCAAATTCATATA
GTTGGTCCTTGATGCGGTTGGCGATGGTGCAATTGGTGCTCAACAATTTGAAGACTTTTTATCCCTTCGCAGGTCATGATCTTGCAGAGC
TTCCAGTTAGTTCACCTCTTTGTCATGCGGTTCTAAAAACTCTTCAATGTTGGGAACAAGTTCTTCTCCGACGACTTGAAATCCATGGTG
GGCCACCTCAAAATTATATCGCAAGTCATACCGCCGAAGAGAGTTTGTCTGCAGGTCCTGCAATTCTTCGCCACAAAGCTTTACTGGAAC
CTACAAACACTCCTTTCAAATCCAAACACCATCTGGCACTGTCTGTGAAGAGGCTTTGGCAGTATTTGGTGAAGCAGGAAGAAATTCAGG
AAACCTTTATCAAAAATATATTCACAAAGAAACGGTGTCTAAATGAGATAGAAGCAGATTTGGGATATCCTGGAGGTAAAGCAAGAATTA
TTCATAAGGAATCTGATATCATTACTGCGTTTGCTGTTAATAAGGCAAATAGAAACTGCATAGCAATCGCTTCCAGTCATGATGTTCAAG
AACTGGATGTTTCTGGAATTCTGGCCACACAGGTCTACACTTGGGTAGATGATGATATAGAAGTGGAAACCAAAGGATCAGAAGATTTCT
TGGTTATACATGCTCGTGATGATTTAACAGCTGTTCAAGGTACAACTCCATATACACATAGCAATCCTGGCACTCCAATCAACATGCCAT
GGCTTGGTAGTACACAGACTGGCAGAGGAGCATCTGTGATGATTAAGAAAGCCATTAATAATGTTAGAAGAATGACTTCTCATCCAACTC
TTCCTTACTATCTGACAGGAGCTCAAGATGGAAGTGTCAGAATGTTTGAATGGGGCCATTCTCAACAAATAACCTGTTTTCGATCTGGTG
GCAATTCAAGAGTTACAAGAATGAGATTTAACTATCAGGGAAATAAGTTTGGAATAGTTGATGCTGATGGATATTTAAGTTTGTATCAAA
CAAACTGGAAATGTTGTCCAGTTACTGGAAGCATGCCTAAGCCATACCTGACTTGGCAGTGTCATAACAAAACAGCCAATGATTTTGTCT
TCGTTAGTTCCTCCTCTCTGATAGCTACAGCTGGTCTTTCAACTGACAATAGAAACGTATGTTTGTGGGATACTCTTGTAGCACCTGCCA
ATAGTTTAGTCCATGCATTTACCTGCCATGACAGTGGAGCCACAGTTTTAGCATATGCTCCAAAACATCAGCTACTAATATCAGGTGGCA
GAAAAGGTTTTACATATGTATTTGACCTTTGTCAACGACAACAGAGGCAGCTTTTCCAGAGCCATGATTCTCCTGTTAAAGCCGTTGCTG
TTGATCCAACTGAAGAGTACTTTGTTACAGGATCTGCCGAAGGCAATATAAAGATTTGGAGTCTCTCTACCTTTGGTCTTCTCCATACTT
TTGTCAGTGAACATGCTCGGCAGTCCATTTTTAGAAATATTGGAACTGGAGTGATGCAAATTGAGACAGGGCCTGCAAATCACATTTTCT
CCTGTGGAGCTGATGGAACAATGAAAATGAGAATACTGCCAGATCAGTTTAGCCCTTTAAATGAAGTGTTGAAAAATGATGTGAAATTTA
TGCTATAACATTTTTACAATAAGATGTACAATTTATTACCTATATGGAAGTGGCCAACAGATATAATATACAGTGATCATTCTCTATGCC
ACAAATTAGCTAATGCTTTCTTGTTTTTATATTTATTTTATGGAGCTTTGCCCTTGATGCACTGATGCCTTAAAAATTAACAAGGTCATT
CAGAAGTAGATTACATTGCCTAAAGTAGAATGTGTAAGTAATGCTGTAATAATACATATCATAGTATATTATAATCAGTATGTCATAGTG
TTAAAGGTGTTTTGTTTTCTTATTGATACTTTTCCACAGGCATCTCTGCATGAATTTCTTCCACAGTAAAAATACGTTTTTTGTAAAGGC
AATTGTACATAATACTCATCACTTAATTCACCACACTCTCACTTCCTTTATTAGCCTTATACATCTCAAACTCTTCTCTTAATTAATGAT
AGGTATTTGAGTAAGAATGAAAAAAATAATGAACATCTTCATTAAAATTGTCATTGAGACGTCAGTGATAAATGAGCTAGATGGCTCAAT
ATGTAAGGTTTTCAGTAGTTTACCCTCCGGAACCCAAGTTGTATGTATGTATACGTGTGTGTGTGTGTGTGTGTGTGTATCTTACACATC
TTATTTGAACTTAGTTGTATATATTAGCGAAAACTGGTTTTTCATGTGTTTTTGTGCCATAACAACTATTGCCACCAGAATAACTTTTTT
TTTGCAACTGTGCTTTTCATTTTTAAAAAATTTTTGAATTCCCATCCTAATTTTCAAATAAGTTTCAAGGAGACTATCAGGATTATTATT
TTAAAGATTAGATTTAGTCAAATAAGTCTTAGCAGGCAATAAAGTTTCTGTGGTGGCATATATCATGTAAGACACTTAAAGTAAGTTTGT
GAATTTGTCAACTTTCGAGCATCAAACAAATATTTTACTTAAATTTTATTTTATCTTATTTTTAGGTGCTTTTAATCTCAAAATTCTGAA
AAGCGAATAGCAGTGTTTTCAGAAACAAATGTGAAAGCAGTCAAATTAAGTAGATACTATTTAGAAATGTAAAATACTCTCCAGATCTAC
CATTAATAGAAAATAAACTAAACCTTATATTTTATTTTTGCCAAAATATTTTATTATAAAATATGACCAAAATATTTAAAATGCACAATG
CTTTTAACTTAAATGTGCTAACCCTGTTTCTGTCTGTTTTGTGCTGTACCTTTTCTGATTCAGAATTATAGAAAACTTGATAAATACTTG
ATTTTAACCAATGAGACTACAGGCAGATGGGACTAAGTGTTTATGGGACAATTATGTACTATTTAACTTAAATATATTTTGTTTAATAGG
AAATATATAATAATAGCATTTTATGTAATAAAATATGGGCAACGATTATCTTGGAAATTAAAGAGTCAAAGCAAAGAAATGAAGGGCTGG
TAAAATGAATTTTGTAATATCCTCAGGATACTTTTATCTTAAAAGTATGTTGTTAAAGATTTTGTAAATTGTATTTCAACAATTTTAAAT
GTGTTGAGCAAGTTGCAGTGCAAACACTGTCATTATGTAGAGAGTTTATATGCACATAATAACCTGTACCTATAAATCGTGCAATAACCA
TATGCGACTATTTTGCCATGGAGAAATCTGACAGCATTGCAAACAATAGTATTGTTTGATGTAGTTAACCTTAAGTTATTTTTCAGTAAT
TTCTTCACAAATCAAGATTCAAACAGCTTTAAACACTTCCAATGAGATAAAATATTTACTATTATGCTTATTAGAACAAAAGGTGTTTAA
GGATGAACTAAATATTTTAATTGAGCATTTATATGGATAATCATACATTATGTAAGCCCATATGTATTTACATCCAGAGTCATAATATTT

>92605_92605_1_TNFAIP8-DMXL1_TNFAIP8_chr5_118604602_ENST00000274456_DMXL1_chr5_118464906_ENST00000311085_length(amino acids)=2650AA_BP=
MSLNENEEKTGPFVVHWLNNKELHFTLSMEVFLQQLRKSFEQPSSEASVEDSNQADVKSDEETDDGVDDLKINPEKKELGCDKMVPNSSF
TSLSSAAIDHQIEVLLSEWSKNADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQVQVSFVSRIPVAFPTGDANSLCKSIMMYACTKNVDL
AIQQGKQKPSGLTRSTSMLISSGHNKSSNSLKLSIFTPNVMMISKHADGSLNQWLVSFAEESAFSTVLSISHKSRYCGHRFHLNDLACHS
VLPLLLTTSHHNALRTPDVDNPEQPFDALNIEECSLTQQNKSTVDVAFQDPSAVYSELILWRVDPVGPLSFSGGVSELARINSLHVSAFS
NVAWLPTLIPSYCLGAYCNSPSACFVASDGQYLRLYEAVIDAKKLLSELSNPEISKYVGEVFNIVSQQSTARPGCIIALDPITKLHGRKT
QLLHVFEEDFILNNLEKKSLGKDSILSNAGSSPNGFSEKFYLIVIECTQDNRSLLHMWNLHLKSIPVSLDEKVDTKLSEAVWQPEEHYSS
SPEKILSPFSQKYQACRANLQSTSRLTLFSEMVYSQELHLPEGVEIISIKPSAGHLSSSSIYPACSAPYLLATSCSDEKVRFWRCRVTDG
ESATSKNGKIDLAYIWEEWPLLIEDGLQSNSSITVPGRPVEVSCAHTNRLAVAYKQPASNSRSSQDFVMHVSIFECESTGGSCWVLEQTI
HLDELSTVLDSGISVDSNLVAYNKQDMYLSSKENITSNTKHLVHLDWMSREDGSHILTVGIGSKLFMYGPLAGKVQDQTGKETLAFPLWE
STKVVPLSKFVLLRSVDLVSSVDGSPPFPVSLSWVRDGILVVGMDCEMHVYCQWQPSSKQEPVITDSYSGSTPSITSLIKQSNSSSGLHP
PKKTLTRSMTSLAQKICGKKTAFDPSVDMEDSGLFEAAHVLSPTLPQYHPLQLLELMDLGKVRRAKAILSHLVKCIAGEVVALNEAESNH
ERRLRSLTISASGSTTRDPQAFNKAENTDYTEIDSVPPLPLYALLAADDDSCYSSLEKSSNESTLSKSNQLSKESYDELFQTQLLMTDTH
MLETDEENTKPRVIDLSQYSPTYFGPEHAQVLSGHLLHSSLPGLSRMEQMSLMALADTIATTSTDIGESRDRSQGGETLDECGLKFLLAV
RLHTFLTTSLPAYRAQLLHQGLSTSHFAWAFHSVAEEELLNMLPAMQKDDPTWSELRAMGVGWWVRNTRILRKCIEKVAKAAFYRKNDPL
DAAIFYLAMKKKAVIWGLYRAEKNTRMTQFFGHNFEDERWRKAALKNAFSLLGKQRFEHSAAFFLLAGCLRDAIEVCLEKLNDIQLALVI
ARLYESEFDTSAAYKSILRKKVLGIDSPVSELCSLNINMHHDPFLRSMAYWILEDYSGALETLIKQPIRENDDQVLSASNPTVFNFYNYL
RTHPLLLRRHFGSSDTFSTHMSLTGKSGLAGTINLSERRLFFTTASAHLKAGCPMLALEVLSKMPKVIKKTRPFYRASSFLDTSKDCSPS
SPLKLDAREDKSSAVDWSQSLINGFGSSSEGSSEKQSNSTLSFDWSQPSVVFQDDSLELKWDSDNDEENEDVPISMKELKPLQRKTDKKL
DDISSNYTESFSTLDENDLLNPSEDIIAVQLKFRACLKILTVELRTLSTGYEIDGGKLRYQLYHWLEKEVIALQRTCDFCSDAEELQSAF
GRNEDEFGLNEDAEDLPHQTKVKQLRENFQEKRQWLLKYQSLLRMFLSYCILHGSHGGGLASVRMELILLLQESQQETSEPLFSSPLSEQ
TSVPLLFACTANAKTVVANPLLHLSNLTHDILHAIINFDSPPHPDIQSNKVYVMHTLAASLSACIYQCLCGSHNYSSFQTNQFTGMVYQT
VLLPHRPSLKTGSLDEALTPNTSPAQWPGITCLIRLLNSSGEEAQSGLTVLLCEILTAVYLSLFIHGLATHSSNELFRIVAHPLNEKMWS
AVFGGGAHVPSKEQTHSKTLPVSSLVEEGEKQNKRFRPSKMSCRESAPLTPSSAPVSQESLAVKEKFIPPELSIWDYFIAKPFLPSSQSR
AEYDSEESLGSDDDDNDDDDDVLASDFHLQEHSNSNSYSWSLMRLAMVQLVLNNLKTFYPFAGHDLAELPVSSPLCHAVLKTLQCWEQVL
LRRLEIHGGPPQNYIASHTAEESLSAGPAILRHKALLEPTNTPFKSKHHLALSVKRLWQYLVKQEEIQETFIKNIFTKKRCLNEIEADLG
YPGGKARIIHKESDIITAFAVNKANRNCIAIASSHDVQELDVSGILATQVYTWVDDDIEVETKGSEDFLVIHARDDLTAVQGTTPYTHSN
PGTPINMPWLGSTQTGRGASVMIKKAINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRSGGNSRVTRMRFNYQGNKFGIVDA
DGYLSLYQTNWKCCPVTGSMPKPYLTWQCHNKTANDFVFVSSSSLIATAGLSTDNRNVCLWDTLVAPANSLVHAFTCHDSGATVLAYAPK
HQLLISGGRKGFTYVFDLCQRQQRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWSLSTFGLLHTFVSEHARQSIFRNIGTGVMQIE

--------------------------------------------------------------
>92605_92605_2_TNFAIP8-DMXL1_TNFAIP8_chr5_118604602_ENST00000274456_DMXL1_chr5_118464906_ENST00000539542_length(transcript)=8407nt_BP=216nt
GACCTCCCGGCTCCTCCCCGGCCTGCCCGCCACACCCTTGGTCCCTCCTGCAAGTTCCGCCCCTGGCCTCTGCCTCCTTTTCTCCCGCCG
GCTCTAACCCGCGCTTGGCTAAGGTCCGCGGGAACCCGTGAGCCACCGAGAGAGCAGAGAACTCGGCGCCGCCAAACAGCCCAGCTCGCG
CTTCAGCGTCCCGGCGCCGTCGCGCCACTCCTCCGAACATTCCACTTCTTCCATCTATTACATCTCTGAGTCTAAATGAAAATGAAGAGA
AGACCGGACCTTTTGTTGTACACTGGCTAAACAATAAAGAACTGCATTTTACTTTGTCCATGGAAGTTTTTTTACAGCAACTTAGAAAAA
GTTTTGAACAACCATCTTCTGAGGCCAGTGTAGAAGATTCTAATCAGGCAGATGTAAAATCTGATGAAGAAACTGATGATGGTGTTGATG
ATCTGAAAATAAATCCCGAAAAGAAGGAATTAGGCTGTGATAAAATGGTACCAAACTCAAGTTTTACATCATTATCGTCAGCTGCCATTG
ATCATCAGATTGAAGTACTTCTGTCTGAATGGAGTAAAAATGCAGATATGCTATTTAGTATTCATCCCATGGATGGTTCTTTGCTAGTTT
GGCATGTGGATTGGCTGGATGAATACCAGCCTGGTATGTTTCGTCAAGTACAGGTGTCCTTTGTTTCCAGAATTCCAGTAGCTTTCCCCA
CAGGTGATGCAAACTCTCTCTGTAAAAGCATAATGATGTATGCCTGTACCAAGAATGTTGACTTGGCTATTCAGCAGGGGAAACAAAAAC
CTTCTGGCCTCACCCGTTCCACATCAATGCTTATTTCTTCTGGTCACAATAAATCATCTAATAGTTTAAAATTAAGTATTTTTACGCCTA
ATGTTATGATGATATCAAAACATGCTGATGGTTCTCTGAATCAGTGGCTGGTCAGTTTTGCCGAGGAATCTGCTTTTTCTACTGTTCTCA
GTATTTCCCACAAATCCAGATATTGTGGTCATCGTTTTCATCTTAATGATTTAGCTTGCCACTCAGTATTACCATTATTGCTGACAACAT
CACACCATAATGCATTAAGGACACCAGATGTTGATAACCCAGAGCAACCTTTTGATGCTCTAAATATTGAAGAATGCTCTTTGACACAAC
AAAATAAAAGCACTGTTGACGTGGCATTTCAGGATCCCAGTGCAGTTTACAGTGAGCTTATTCTGTGGAGGGTTGACCCAGTTGGGCCAT
TGTCTTTTTCTGGAGGAGTTTCTGAGCTTGCCCGGATTAATTCTCTTCATGTTTCTGCCTTTTCCAATGTGGCATGGCTGCCCACTCTTA
TACCCAGTTATTGTCTGGGTGCATACTGCAACTCTCCTAGTGCATGCTTTGTAGCCAGTGATGGACAATATCTGAGATTATATGAAGCAG
TTATTGATGCTAAGAAACTTTTATCTGAGCTTTCTAACCCTGAAATTTCTAAATATGTTGGTGAAGTCTTTAACATCGTCAGTCAACAAT
CAACAGCCAGGCCAGGATGCATTATTGCATTAGATCCCATTACCAAACTTCATGGCAGAAAAACCCAACTGCTTCATGTTTTTGAAGAAG
ACTTCATTTTGAATAACCTTGAGAAGAAAAGCCTTGGCAAAGACAGCATTTTATCTAATGCAGGCAGCTCACCTAATGGATTTTCTGAGA
AGTTCTACCTAATTGTAATAGAATGCACTCAAGACAACCGTTCACTGTTACACATGTGGAATTTACATCTAAAGTCAATTCCTGTCTCAT
TAGATGAAAAAGTAGATACAAAATTATCCGAAGCGGTTTGGCAGCCAGAAGAACATTATTCTTCTTCTCCAGAGAAGATCCTATCTCCTT
TTTCACAAAAGTATCAGGCTTGCAGAGCAAATCTCCAGAGTACCAGCAGGTTGACTCTGTTTTCAGAAATGGTTTATAGCCAAGAATTGC
ATTTACCAGAAGGAGTTGAGATAATAAGTATTAAGCCATCAGCAGGACATCTGAGTTCATCTTCTATATATCCTGCATGCAGTGCTCCTT
ATTTATTGGCAACTTCATGTTCAGATGAGAAAGTAAGATTCTGGAGATGCAGAGTAACAGATGGAGAATCTGCCACGTCAAAGAATGGAA
AAATTGATCTTGCATACATTTGGGAAGAATGGCCATTACTTATTGAAGATGGACTTCAGAGCAATAGTAGTATAACTGTACCTGGTAGGC
CTGTAGAAGTTAGCTGTGCACATACAAATCGTTTAGCAGTAGCTTATAAGCAGCCTGCATCTAATAGTAGATCTTCCCAGGACTTTGTGA
TGCATGTAAGTATTTTTGAATGTGAGTCAACAGGAGGTTCATGTTGGGTCCTTGAGCAGACAATTCATTTAGATGAGTTAAGCACAGTAT
TGGATTCTGGCATTAGTGTTGATAGCAATTTAGTGGCCTATAATAAACAAGACATGTATTTATCTAGTAAAGAGAATATCACATCAAACA
CAAAGCATTTAGTTCACTTAGATTGGATGTCTAGAGAAGACGGTTCTCATATCCTGACTGTAGGAATTGGATCAAAACTTTTTATGTATG
GACCCCTGGCTGGCAAGGTACAAGACCAAACTGGTAAGGAAACCCTGGCATTTCCTCTCTGGGAGAGTACCAAAGTTGTGCCCCTTTCTA
AATTTGTACTATTACGAAGTGTGGACCTAGTTTCTTCTGTAGATGGCTCCCCACCTTTTCCTGTTTCTTTATCGTGGGTCCGGGATGGCA
TCCTTGTGGTAGGAATGGACTGTGAAATGCATGTGTATTGCCAATGGCAACCATCTTCTAAACAAGAACCTGTTATAACAGATTCGTACA
GTGGGAGCACTCCATCTATAACAAGTTTAATAAAACAGAGTAACTCCAGTTCTGGGTTACATCCTCCAAAGAAAACTCTGACTCGATCCA
TGACCAGTCTTGCACAGAAAATCTGTGGAAAGAAAACTGCATTCGATCCTTCAGTGGATATGGAAGATTCAGGTCTTTTTGAAGCAGCTC
ATGTACTTTCCCCGACTCTACCTCAGTATCATCCCTTGCAGCTTTTGGAACTCATGGATCTTGGTAAAGTTCGGAGAGCCAAGGCCATCT
TGTCCCATCTTGTTAAGTGCATTGCTGGGGAAGTTGTGGCTCTGAATGAAGCTGAATCTAATCATGAACGCCGCCTTAGGTCTCTCACAA
TCAGTGCTAGTGGAAGCACTACCAGAGACCCCCAGGCATTCAACAAGGCTGAAAATACAGATTACACAGAAATAGATTCTGTTCCTCCAC
TTCCTTTATATGCCTTACTTGCAGCAGATGATGATAGCTGTTACTCATCTTTGGAGAAATCTAGTAATGAGAGTACGTTAAGTAAATCAA
ACCAATTATCTAAAGAAAGTTATGATGAGCTTTTTCAGACTCAACTTCTAATGACTGATACTCATATGTTAGAGACAGATGAAGAAAATA
CAAAGCCTAGAGTTATTGACCTTTCACAGTACAGTCCGACTTACTTTGGACCTGAGCATGCTCAGGTTCTTTCTGGCCACTTACTTCATT
CTAGTTTACCAGGACTCAGCCGGATGGAGCAGATGTCTTTGATGGCCTTAGCAGATACAATTGCAACTACAAGCACTGATATTGGAGAAA
GCCGAGACAGAAGCCAAGGTGGAGAAACTCTTGATGAATGTGGGTTAAAATTTCTTTTGGCTGTTCGACTCCATACCTTTCTTACAACTT
CCCTTCCAGCCTATCGAGCTCAACTCCTTCACCAAGGCCTGTCTACAAGTCATTTTGCTTGGGCATTTCACTCAGTAGCAGAAGAAGAAC
TGCTGAACATGTTGCCAGCCATGCAGAAAGATGATCCCACTTGGTCTGAACTAAGAGCTATGGGTGTGGGGTGGTGGGTCCGGAATACCC
GCATCTTACGCAAATGCATAGAAAAAGTAGCTAAAGCAGCCTTTTATAGAAAGAATGATCCTTTAGATGCTGCCATTTTTTACCTTGCAA
TGAAAAAGAAAGCTGTGATTTGGGGATTATATAGAGCTGAAAAAAACACCAGGATGACACAGTTTTTTGGACACAATTTTGAGGATGAGA
GGTGGCGTAAAGCAGCTTTAAAGAATGCTTTTTCTTTGCTAGGCAAACAAAGATTTGAACATTCTGCAGCATTTTTTCTTTTAGCTGGTT
GCCTCAGAGATGCAATTGAGGTATGTCTTGAGAAATTGAATGACATTCAGTTGGCTCTTGTAATAGCAAGACTCTATGAGTCTGAATTTG
ATACATCTGCAGCATATAAATCTATTTTACGTAAAAAAGTTTTGGGAATCGATTCTCCTGTCAGTGAACTGTGTTCATTGAACATAAATA
TGCATCATGATCCTTTTCTTCGGAGCATGGCATATTGGATTTTGGAAGATTATAGTGGTGCTCTGGAAACATTAATAAAGCAACCTATCA
GAGAGAATGATGATCAAGTTTTATCAGCCAGTAATCCTACAGTTTTTAATTTCTACAATTATCTAAGAACACATCCTCTTTTGCTGAGAC
GTCATTTTGGATCATCTGATACATTTTCCACACATATGAGCCTAACAGGAAAAAGTGGACTGGCAGGAACAATTAATTTAAGTGAAAGAC
GTTTATTTTTTACCACTGCCAGTGCTCATTTAAAAGCTGGCTGCCCAATGTTGGCTTTGGAAGTATTATCAAAGATGCCTAAAGTCATCA
AGAAAACAAGACCTTTTTATAGGGCTTCTAGTTTTCTGGATACTAGTAAAGACTGTTCTCCTTCTTCTCCATTAAAGTTGGATGCAAGGG
AAGATAAGTCTTCTGCTGTTGATTGGTCACAGTCACTGATAAATGGTTTTGGATCTTCTTCAGAGGGTTCCTCAGAGAAGCAATCAAACT
CCACTCTTTCTTTTGACTGGAGCCAACCAAGTGTTGTGTTTCAGGATGACTCTTTAGAGTTAAAATGGGACAGTGATAATGATGAAGAAA
ATGAGGATGTCCCTATTTCAATGAAAGAACTAAAACCTTTACAGAGAAAAACAGATAAAAAGTTGGATGACATAAGTTCTAACTACACAG
AATCTTTCAGCACACTAGATGAAAATGACCTTTTAAATCCATCAGAAGATATAATTGCAGTTCAGTTAAAATTTAGAGCATGTTTAAAGA
TTCTCACAGTAGAACTTCGTACTTTATCTACTGGCTATGAAATAGATGGTGGAAAATTGCGTTACCAACTATACCACTGGCTTGAAAAAG
AGGTGATAGCTCTTCAGAGGACTTGTGACTTTTGCTCAGATGCTGAAGAACTACAGTCTGCATTTGGCAGAAATGAAGATGAATTTGGAT
TAAATGAGGATGCTGAAGATTTGCCTCACCAAACAAAAGTGAAACAACTGAGAGAAAATTTTCAGGAAAAAAGACAGTGGCTCTTGAAGT
ATCAGTCACTTTTGAGAATGTTTCTTAGTTACTGCATACTTCATGGATCCCATGGTGGGGGTCTTGCATCTGTAAGAATGGAATTGATTT
TGCTTTTGCAAGAATCTCAGCAGGAAACATCAGAACCACTATTTTCTAGCCCTCTGTCAGAGCAAACCTCAGTGCCTCTCCTCTTTGCTT
GTACAGCCAATGCCAAAACAGTAGTTGCCAATCCATTATTGCACCTTAGTAATCTGACACATGATATTCTCCATGCCATAATAAACTTTG
ATTCACCACCCCACCCTGATATCCAAAGCAATAAAGTGTATGTAATGCATACTTTAGCAGCTTCACTTTCTGCTTGTATTTATCAGTGCC
TTTGTGGTAGTCATAACTACAGTTCATTTCAGACGAATCAGTTTACTGGAATGGTATATCAGACAGTACTGCTTCCTCATCGACCTTCTT
TGAAAACAGGAAGCTTAGATGAAGCATTAACTCCCAATACGTCACCAGCTCAATGGCCAGGAATAACTTGTCTAATTCGACTTTTGAATT
CTTCTGGCGAGGAAGCCCAGTCAGGGCTTACAGTCTTGCTCTGTGAGATTCTCACAGCAGTGTATCTTAGTCTCTTCATCCATGGCCTGG
CCACACATTCAAGTAATGAGCTATTTCGGATTGTGGCCCATCCTCTAAATGAGAAAATGTGGTCTGCTGTGTTTGGTGGAGGTGCACATG
TTCCTAGCAAAGAACAGACACATTCAAAAACTTTACCTGTTTCTTCACTAGTTGAAGAAGGAGAAAAACAGAACAAACGTTTTAGGCCGT
CAAAAATGTCTTGCAGAGAATCTGCCCCACTGACCCCTTCCTCGGCACCAGTAAGCCAGGAGTCACTGGCGGTTAAAGAAAAGTTCATCC
CACCTGAGCTCAGTATCTGGGACTATTTCATAGCTAAGCCTTTTCTACCCTCTTCTCAAAGTAGAGCCGAATATGATTCAGAGGAGAGTC
TGGGAAGTGATGATGATGACAATGATGATGATGATGATGTTTTAGCATCAGATTTCCATCTCCAGGAACATTCTAATTCAAATTCATATA
GTTGGTCCTTGATGCGGTTGGCGATGGTGCAATTGGTGCTCAACAATTTGAAGACTTTTTATCCCTTCGCAGGTCATGATCTTGCAGAGC
TTCCAGTTAGTTCACCTCTTTGTCATGCGGTTCTAAAAACTCTTCAATGTTGGGAACAAGTTCTTCTCCGACGACTTGAAATCCATGGTG
GGCCACCTCAAAATTATATCGCAAGTCATACCGCCGAAGAGAGTTTGTCTGCAGGTCCTGCAATTCTTCGCCACAAAGCTTTACTGGAAC
CTACAAACACTCCTTTCAAATCCAAACACCATCTGGCACTGTCTGTGAAGAGGCTTTGGCAGTATTTGGTGAAGCAGGAAGAAATTCAGG
AAACCTTTATCAAAAATATATTCACAAAGAAACGGTGTCTAAATGAGTCATTAGAGGACAACAGTGAAACCATCAAAAATTCTATGATGG
AGGAGCCAAACATCAATAAGATAGAAGCAGATTTGGGATATCCTGGAGGTAAAGCAAGAATTATTCATAAGGAATCTGATATCATTACTG
CGTTTGCTGTTAATAAGGCAAATAGAAACTGCATAGCAATCGCTTCCAGTCATGATGTTCAAGAACTGGATGTTTCTGGAATTCTGGCCA
CACAGGTCTACACTTGGGTAGATGATGATATAGAAGTGGAAACCAAAGGATCAGAAGATTTCTTGGTTATACATGCTCGTGATGATTTAA
CAGCTGTTCAAGGTACAACTCCATATACACATAGCAATCCTGGCACTCCAATCAACATGCCATGGCTTGGTAGTACACAGACTGGCAGAG
GAGCATCTGTGATGATTAAGAAAGCCATTAATAATGTTAGAAGAATGACTTCTCATCCAACTCTTCCTTACTATCTGACAGGAGCTCAAG
ATGGAAGTGTCAGAATGTTTGAATGGGGCCATTCTCAACAAATAACCTGTTTTCGATCTGGTGGCAATTCAAGAGTTACAAGAATGAGAT
TTAACTATCAGGGAAATAAGTTTGGAATAGTTGATGCTGATGGATATTTAAGTTTGTATCAAACAAACTGGAAATGTTGTCCAGTTACTG
GAAGCATGCCTAAGCCATACCTGACTTGGCAGTGTCATAACAAAACAGCCAATGATTTTGTCTTCGTTAGTTCCTCCTCTCTGATAGCTA
CAGCTGGTCTTTCAACTGACAATAGAAACGTATGTTTGTGGGATACTCTTGTAGCACCTGCCAATAGTTTAGTCCATGCATTTACCTGCC
ATGACAGTGGAGCCACAGTTTTAGCATATGCTCCAAAACATCAGCTACTAATATCAGGTGGCAGAAAAGGTTTTACATATGTATTTGACC
TTTGTCAACGACAACAGAGGCAGCTTTTCCAGAGCCATGATTCTCCTGTTAAAGCCGTTGCTGTTGATCCAACTGAAGAGTACTTTGTTA
CAGGATCTGCCGAAGGCAATATAAAGATTTGGAGTCTCTCTACCTTTGGTCTTCTCCATACTTTTGTCAGTGAACATGCTCGGCAGTCCA
TTTTTAGAAATATTGGAACTGGAGTGATGCAAATTGAGACAGGGCCTGCAAATCACATTTTCTCCTGTGGAGCTGATGGAACAATGAAAA
TGAGAATACTGCCAGATCAGTTTAGCCCTTTAAATGAAGTGTTGAAAAATGATGTGAAATTTATGCTATAACATTTTTACAATAAGATGT
ACAATTTATTACCTATATGGAAGTGGCCAACAGATATAATATACAGTGATCATTCTCTATGCCACAAATTAGCTAATGCTTTCTTGTTTT

>92605_92605_2_TNFAIP8-DMXL1_TNFAIP8_chr5_118604602_ENST00000274456_DMXL1_chr5_118464906_ENST00000539542_length(amino acids)=2671AA_BP=
MSLNENEEKTGPFVVHWLNNKELHFTLSMEVFLQQLRKSFEQPSSEASVEDSNQADVKSDEETDDGVDDLKINPEKKELGCDKMVPNSSF
TSLSSAAIDHQIEVLLSEWSKNADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQVQVSFVSRIPVAFPTGDANSLCKSIMMYACTKNVDL
AIQQGKQKPSGLTRSTSMLISSGHNKSSNSLKLSIFTPNVMMISKHADGSLNQWLVSFAEESAFSTVLSISHKSRYCGHRFHLNDLACHS
VLPLLLTTSHHNALRTPDVDNPEQPFDALNIEECSLTQQNKSTVDVAFQDPSAVYSELILWRVDPVGPLSFSGGVSELARINSLHVSAFS
NVAWLPTLIPSYCLGAYCNSPSACFVASDGQYLRLYEAVIDAKKLLSELSNPEISKYVGEVFNIVSQQSTARPGCIIALDPITKLHGRKT
QLLHVFEEDFILNNLEKKSLGKDSILSNAGSSPNGFSEKFYLIVIECTQDNRSLLHMWNLHLKSIPVSLDEKVDTKLSEAVWQPEEHYSS
SPEKILSPFSQKYQACRANLQSTSRLTLFSEMVYSQELHLPEGVEIISIKPSAGHLSSSSIYPACSAPYLLATSCSDEKVRFWRCRVTDG
ESATSKNGKIDLAYIWEEWPLLIEDGLQSNSSITVPGRPVEVSCAHTNRLAVAYKQPASNSRSSQDFVMHVSIFECESTGGSCWVLEQTI
HLDELSTVLDSGISVDSNLVAYNKQDMYLSSKENITSNTKHLVHLDWMSREDGSHILTVGIGSKLFMYGPLAGKVQDQTGKETLAFPLWE
STKVVPLSKFVLLRSVDLVSSVDGSPPFPVSLSWVRDGILVVGMDCEMHVYCQWQPSSKQEPVITDSYSGSTPSITSLIKQSNSSSGLHP
PKKTLTRSMTSLAQKICGKKTAFDPSVDMEDSGLFEAAHVLSPTLPQYHPLQLLELMDLGKVRRAKAILSHLVKCIAGEVVALNEAESNH
ERRLRSLTISASGSTTRDPQAFNKAENTDYTEIDSVPPLPLYALLAADDDSCYSSLEKSSNESTLSKSNQLSKESYDELFQTQLLMTDTH
MLETDEENTKPRVIDLSQYSPTYFGPEHAQVLSGHLLHSSLPGLSRMEQMSLMALADTIATTSTDIGESRDRSQGGETLDECGLKFLLAV
RLHTFLTTSLPAYRAQLLHQGLSTSHFAWAFHSVAEEELLNMLPAMQKDDPTWSELRAMGVGWWVRNTRILRKCIEKVAKAAFYRKNDPL
DAAIFYLAMKKKAVIWGLYRAEKNTRMTQFFGHNFEDERWRKAALKNAFSLLGKQRFEHSAAFFLLAGCLRDAIEVCLEKLNDIQLALVI
ARLYESEFDTSAAYKSILRKKVLGIDSPVSELCSLNINMHHDPFLRSMAYWILEDYSGALETLIKQPIRENDDQVLSASNPTVFNFYNYL
RTHPLLLRRHFGSSDTFSTHMSLTGKSGLAGTINLSERRLFFTTASAHLKAGCPMLALEVLSKMPKVIKKTRPFYRASSFLDTSKDCSPS
SPLKLDAREDKSSAVDWSQSLINGFGSSSEGSSEKQSNSTLSFDWSQPSVVFQDDSLELKWDSDNDEENEDVPISMKELKPLQRKTDKKL
DDISSNYTESFSTLDENDLLNPSEDIIAVQLKFRACLKILTVELRTLSTGYEIDGGKLRYQLYHWLEKEVIALQRTCDFCSDAEELQSAF
GRNEDEFGLNEDAEDLPHQTKVKQLRENFQEKRQWLLKYQSLLRMFLSYCILHGSHGGGLASVRMELILLLQESQQETSEPLFSSPLSEQ
TSVPLLFACTANAKTVVANPLLHLSNLTHDILHAIINFDSPPHPDIQSNKVYVMHTLAASLSACIYQCLCGSHNYSSFQTNQFTGMVYQT
VLLPHRPSLKTGSLDEALTPNTSPAQWPGITCLIRLLNSSGEEAQSGLTVLLCEILTAVYLSLFIHGLATHSSNELFRIVAHPLNEKMWS
AVFGGGAHVPSKEQTHSKTLPVSSLVEEGEKQNKRFRPSKMSCRESAPLTPSSAPVSQESLAVKEKFIPPELSIWDYFIAKPFLPSSQSR
AEYDSEESLGSDDDDNDDDDDVLASDFHLQEHSNSNSYSWSLMRLAMVQLVLNNLKTFYPFAGHDLAELPVSSPLCHAVLKTLQCWEQVL
LRRLEIHGGPPQNYIASHTAEESLSAGPAILRHKALLEPTNTPFKSKHHLALSVKRLWQYLVKQEEIQETFIKNIFTKKRCLNESLEDNS
ETIKNSMMEEPNINKIEADLGYPGGKARIIHKESDIITAFAVNKANRNCIAIASSHDVQELDVSGILATQVYTWVDDDIEVETKGSEDFL
VIHARDDLTAVQGTTPYTHSNPGTPINMPWLGSTQTGRGASVMIKKAINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRSGG
NSRVTRMRFNYQGNKFGIVDADGYLSLYQTNWKCCPVTGSMPKPYLTWQCHNKTANDFVFVSSSSLIATAGLSTDNRNVCLWDTLVAPAN
SLVHAFTCHDSGATVLAYAPKHQLLISGGRKGFTYVFDLCQRQQRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWSLSTFGLLHTF

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Fusion Gene PPI Analysis for TNFAIP8-DMXL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TNFAIP8-DMXL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TNFAIP8-DMXL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource