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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TNIK-DPPA2 (FusionGDB2 ID:92691)

Fusion Gene Summary for TNIK-DPPA2

check button Fusion gene summary
Fusion gene informationFusion gene name: TNIK-DPPA2
Fusion gene ID: 92691
HgeneTgene
Gene symbol

TNIK

DPPA2

Gene ID

23043

151871

Gene nameTRAF2 and NCK interacting kinasedevelopmental pluripotency associated 2
SynonymsMRT54CT100|ECAT15-2|PESCRG1
Cytomap

3q26.2-q26.31

3q13.13

Type of geneprotein-codingprotein-coding
DescriptionTRAF2 and NCK-interacting protein kinasedevelopmental pluripotency-associated protein 2cancer/testis antigen 100embryonic stem cell (ESC) associated transcript 15-2pluripotent embryonic stem cell-related gene 1 protein
Modification date2020031320200313
UniProtAcc.

Q7Z7J5

Ensembl transtripts involved in fusion geneENST00000341852, ENST00000357327, 
ENST00000436636, ENST00000488470, 
ENST00000284483, ENST00000369326, 
ENST00000460047, ENST00000464785, 
ENST00000465393, ENST00000470834, 
ENST00000475336, ENST00000538048, 
ENST00000478945, 
Fusion gene scores* DoF score14 X 13 X 6=10921 X 1 X 1=1
# samples 132
** MAII scorelog2(13/1092*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/1*10)=4.32192809488736
Context

PubMed: TNIK [Title/Abstract] AND DPPA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTNIK(170824971)-DPPA2(109019282), # samples:1
TNIK(170824972)-DPPA2(109019282), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNIK

GO:0006468

protein phosphorylation

10521462|15342639|22797597

HgeneTNIK

GO:0007256

activation of JNKK activity

15342639

HgeneTNIK

GO:0031532

actin cytoskeleton reorganization

15342639

HgeneTNIK

GO:0035556

intracellular signal transduction

10521462

HgeneTNIK

GO:0046777

protein autophosphorylation

10521462|15342639

HgeneTNIK

GO:0048814

regulation of dendrite morphogenesis

20159449


check buttonFusion gene breakpoints across TNIK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DPPA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PE-01ATNIKchr3

170824972

-DPPA2chr3

109019282

-
ChimerDB4STADTCGA-BR-A4PETNIKchr3

170824971

-DPPA2chr3

109019282

-


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Fusion Gene ORF analysis for TNIK-DPPA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000341852ENST00000478945TNIKchr3

170824972

-DPPA2chr3

109019282

-
In-frameENST00000341852ENST00000478945TNIKchr3

170824971

-DPPA2chr3

109019282

-
In-frameENST00000357327ENST00000478945TNIKchr3

170824972

-DPPA2chr3

109019282

-
In-frameENST00000357327ENST00000478945TNIKchr3

170824971

-DPPA2chr3

109019282

-
In-frameENST00000436636ENST00000478945TNIKchr3

170824972

-DPPA2chr3

109019282

-
In-frameENST00000436636ENST00000478945TNIKchr3

170824971

-DPPA2chr3

109019282

-
In-frameENST00000488470ENST00000478945TNIKchr3

170824972

-DPPA2chr3

109019282

-
In-frameENST00000488470ENST00000478945TNIKchr3

170824971

-DPPA2chr3

109019282

-
intron-3CDSENST00000284483ENST00000478945TNIKchr3

170824972

-DPPA2chr3

109019282

-
intron-3CDSENST00000284483ENST00000478945TNIKchr3

170824971

-DPPA2chr3

109019282

-
intron-3CDSENST00000369326ENST00000478945TNIKchr3

170824972

-DPPA2chr3

109019282

-
intron-3CDSENST00000369326ENST00000478945TNIKchr3

170824971

-DPPA2chr3

109019282

-
intron-3CDSENST00000460047ENST00000478945TNIKchr3

170824972

-DPPA2chr3

109019282

-
intron-3CDSENST00000460047ENST00000478945TNIKchr3

170824971

-DPPA2chr3

109019282

-
intron-3CDSENST00000464785ENST00000478945TNIKchr3

170824972

-DPPA2chr3

109019282

-
intron-3CDSENST00000464785ENST00000478945TNIKchr3

170824971

-DPPA2chr3

109019282

-
intron-3CDSENST00000465393ENST00000478945TNIKchr3

170824972

-DPPA2chr3

109019282

-
intron-3CDSENST00000465393ENST00000478945TNIKchr3

170824971

-DPPA2chr3

109019282

-
intron-3CDSENST00000470834ENST00000478945TNIKchr3

170824972

-DPPA2chr3

109019282

-
intron-3CDSENST00000470834ENST00000478945TNIKchr3

170824971

-DPPA2chr3

109019282

-
intron-3CDSENST00000475336ENST00000478945TNIKchr3

170824972

-DPPA2chr3

109019282

-
intron-3CDSENST00000475336ENST00000478945TNIKchr3

170824971

-DPPA2chr3

109019282

-
intron-3CDSENST00000538048ENST00000478945TNIKchr3

170824972

-DPPA2chr3

109019282

-
intron-3CDSENST00000538048ENST00000478945TNIKchr3

170824971

-DPPA2chr3

109019282

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000436636TNIKchr3170824971-ENST00000478945DPPA2chr3109019282-303327513152756813
ENST00000341852TNIKchr3170824971-ENST00000478945DPPA2chr3109019282-278124993152504729
ENST00000488470TNIKchr3170824971-ENST00000478945DPPA2chr3109019282-2523224102246748
ENST00000357327TNIKchr3170824971-ENST00000478945DPPA2chr3109019282-2601231902324774
ENST00000436636TNIKchr3170824972-ENST00000478945DPPA2chr3109019282-303327513152756813
ENST00000341852TNIKchr3170824972-ENST00000478945DPPA2chr3109019282-278124993152504729
ENST00000488470TNIKchr3170824972-ENST00000478945DPPA2chr3109019282-2523224102246748
ENST00000357327TNIKchr3170824972-ENST00000478945DPPA2chr3109019282-2601231902324774

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000436636ENST00000478945TNIKchr3170824971-DPPA2chr3109019282-0.0125256550.9874743
ENST00000341852ENST00000478945TNIKchr3170824971-DPPA2chr3109019282-0.0096793120.9903206
ENST00000488470ENST00000478945TNIKchr3170824971-DPPA2chr3109019282-0.0186905580.9813095
ENST00000357327ENST00000478945TNIKchr3170824971-DPPA2chr3109019282-0.0158269890.98417294
ENST00000436636ENST00000478945TNIKchr3170824972-DPPA2chr3109019282-0.0125256550.9874743
ENST00000341852ENST00000478945TNIKchr3170824972-DPPA2chr3109019282-0.0096793120.9903206
ENST00000488470ENST00000478945TNIKchr3170824972-DPPA2chr3109019282-0.0186905580.9813095
ENST00000357327ENST00000478945TNIKchr3170824972-DPPA2chr3109019282-0.0158269890.98417294

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Fusion Genomic Features for TNIK-DPPA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TNIK-DPPA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:170824971/chr3:109019282)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DPPA2

Q7Z7J5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNIKchr3:170824971chr3:109019282ENST00000341852-193125_2897181277.0DomainProtein kinase
HgeneTNIKchr3:170824971chr3:109019282ENST00000357327-203225_2897731332.0DomainProtein kinase
HgeneTNIKchr3:170824971chr3:109019282ENST00000436636-213325_2898021361.0DomainProtein kinase
HgeneTNIKchr3:170824971chr3:109019282ENST00000488470-203225_2897471306.0DomainProtein kinase
HgeneTNIKchr3:170824972chr3:109019282ENST00000341852-193125_2897181277.0DomainProtein kinase
HgeneTNIKchr3:170824972chr3:109019282ENST00000357327-203225_2897731332.0DomainProtein kinase
HgeneTNIKchr3:170824972chr3:109019282ENST00000436636-213325_2898021361.0DomainProtein kinase
HgeneTNIKchr3:170824972chr3:109019282ENST00000488470-203225_2897471306.0DomainProtein kinase
HgeneTNIKchr3:170824971chr3:109019282ENST00000341852-193131_397181277.0Nucleotide bindingATP
HgeneTNIKchr3:170824971chr3:109019282ENST00000357327-203231_397731332.0Nucleotide bindingATP
HgeneTNIKchr3:170824971chr3:109019282ENST00000436636-213331_398021361.0Nucleotide bindingATP
HgeneTNIKchr3:170824971chr3:109019282ENST00000488470-203231_397471306.0Nucleotide bindingATP
HgeneTNIKchr3:170824972chr3:109019282ENST00000341852-193131_397181277.0Nucleotide bindingATP
HgeneTNIKchr3:170824972chr3:109019282ENST00000357327-203231_397731332.0Nucleotide bindingATP
HgeneTNIKchr3:170824972chr3:109019282ENST00000436636-213331_398021361.0Nucleotide bindingATP
HgeneTNIKchr3:170824972chr3:109019282ENST00000488470-203231_397471306.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNIKchr3:170824971chr3:109019282ENST00000284483-1321047_133401353.0DomainCNH
HgeneTNIKchr3:170824971chr3:109019282ENST00000284483-13225_28901353.0DomainProtein kinase
HgeneTNIKchr3:170824971chr3:109019282ENST00000341852-19311047_13347181277.0DomainCNH
HgeneTNIKchr3:170824971chr3:109019282ENST00000357327-20321047_13347731332.0DomainCNH
HgeneTNIKchr3:170824971chr3:109019282ENST00000436636-21331047_13348021361.0DomainCNH
HgeneTNIKchr3:170824971chr3:109019282ENST00000460047-1311047_133401298.0DomainCNH
HgeneTNIKchr3:170824971chr3:109019282ENST00000460047-13125_28901298.0DomainProtein kinase
HgeneTNIKchr3:170824971chr3:109019282ENST00000470834-1311047_133401324.0DomainCNH
HgeneTNIKchr3:170824971chr3:109019282ENST00000470834-13125_28901324.0DomainProtein kinase
HgeneTNIKchr3:170824971chr3:109019282ENST00000475336-1301047_133401269.0DomainCNH
HgeneTNIKchr3:170824971chr3:109019282ENST00000475336-13025_28901269.0DomainProtein kinase
HgeneTNIKchr3:170824971chr3:109019282ENST00000488470-20321047_13347471306.0DomainCNH
HgeneTNIKchr3:170824972chr3:109019282ENST00000284483-1321047_133401353.0DomainCNH
HgeneTNIKchr3:170824972chr3:109019282ENST00000284483-13225_28901353.0DomainProtein kinase
HgeneTNIKchr3:170824972chr3:109019282ENST00000341852-19311047_13347181277.0DomainCNH
HgeneTNIKchr3:170824972chr3:109019282ENST00000357327-20321047_13347731332.0DomainCNH
HgeneTNIKchr3:170824972chr3:109019282ENST00000436636-21331047_13348021361.0DomainCNH
HgeneTNIKchr3:170824972chr3:109019282ENST00000460047-1311047_133401298.0DomainCNH
HgeneTNIKchr3:170824972chr3:109019282ENST00000460047-13125_28901298.0DomainProtein kinase
HgeneTNIKchr3:170824972chr3:109019282ENST00000470834-1311047_133401324.0DomainCNH
HgeneTNIKchr3:170824972chr3:109019282ENST00000470834-13125_28901324.0DomainProtein kinase
HgeneTNIKchr3:170824972chr3:109019282ENST00000475336-1301047_133401269.0DomainCNH
HgeneTNIKchr3:170824972chr3:109019282ENST00000475336-13025_28901269.0DomainProtein kinase
HgeneTNIKchr3:170824972chr3:109019282ENST00000488470-20321047_13347471306.0DomainCNH
HgeneTNIKchr3:170824971chr3:109019282ENST00000284483-13231_3901353.0Nucleotide bindingATP
HgeneTNIKchr3:170824971chr3:109019282ENST00000460047-13131_3901298.0Nucleotide bindingATP
HgeneTNIKchr3:170824971chr3:109019282ENST00000470834-13131_3901324.0Nucleotide bindingATP
HgeneTNIKchr3:170824971chr3:109019282ENST00000475336-13031_3901269.0Nucleotide bindingATP
HgeneTNIKchr3:170824972chr3:109019282ENST00000284483-13231_3901353.0Nucleotide bindingATP
HgeneTNIKchr3:170824972chr3:109019282ENST00000460047-13131_3901298.0Nucleotide bindingATP
HgeneTNIKchr3:170824972chr3:109019282ENST00000470834-13131_3901324.0Nucleotide bindingATP
HgeneTNIKchr3:170824972chr3:109019282ENST00000475336-13031_3901269.0Nucleotide bindingATP
TgeneDPPA2chr3:170824971chr3:109019282ENST000004789456992_126284299.6666666666667DomainSAP
TgeneDPPA2chr3:170824972chr3:109019282ENST000004789456992_126284299.6666666666667DomainSAP


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Fusion Gene Sequence for TNIK-DPPA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92691_92691_1_TNIK-DPPA2_TNIK_chr3_170824971_ENST00000341852_DPPA2_chr3_109019282_ENST00000478945_length(transcript)=2781nt_BP=2499nt
ATTATAACAGCCAATGCAGCCGCCATCCACGCACAAGCAAAGAAGCATGTCCCATTTAAATACACCCACGCAGCCCCAGCGCCCTTAGCC
GATCGGGGCGCTCAGCCCACACGCACCGCTGCTCGGGGCTTGGAGATCCGCGCAGGCTGGGCTCCCGGACCCGGCGGACCGACGCGCGGA
GGATCGGGATCCGGCGCTGTGGGGCTGGGGTGGGCGGGGGAGGCTGGGCCCGGGGCCTCTGGCGCGACACCCGCATGAGGACGCGAGTGA
AATAGACCAAGGTGGAATTTCCAAGGGAAAAGCTTCGGGGTGGTTTTGGTCCATTTCTCCAGCGAAGAAGTAGACATGGCGAGCGACTCC
CCGGCTCGAAGCCTGGATGAAATAGATCTCTCGGCTCTGAGGGACCCCGCAGGGATCTTTGAATTGGTGGAACTTGTTGGAAATGGAACA
TACGGGCAAGTTTATAAGGGTCGTCATGTCAAAACGGGCCAGCTTGCAGCCATCAAGGTTATGGATGTCACAGGGGATGAAGAGGAAGAA
ATCAAACAAGAAATTAACATGTTGAAGAAATATTCTCATCACCGGAATATTGCTACATACTATGGTGCTTTTATCAAAAAGAACCCACCA
GGCATGGATGACCAACTTTGGTTGGTGATGGAGTTTTGTGGTGCTGGCTCTGTCACCGACCTGATCAAGAACACAAAAGGTAACACGTTG
AAAGAGGAGTGGATTGCATACATCTGCAGGGAAATCTTACGGGGGCTGAGTCACCTGCACCAGCATAAAGTGATTCATCGAGATATTAAA
GGGCAAAATGTCTTGCTGACTGAAAATGCAGAAGTTAAACTAGTGGACTTTGGAGTCAGTGCTCAGCTTGATCGAACAGTGGGCAGGAGG
AATACTTTCATTGGAACTCCCTACTGGATGGCACCAGAAGTTATTGCCTGTGATGAAAACCCAGATGCCACATATGATTTCAAGAGTGAC
TTGTGGTCTTTGGGTATCACCGCCATTGAAATGGCAGAAGGTGCTCCCCCTCTCTGTGACATGCACCCCATGAGAGCTCTCTTCCTCATC
CCCCGGAACCCAGCGCCTCGGCTGAAGTCTAAGAAGTGGTCAAAAAAATTCCAGTCATTTATTGAGAGCTGCTTGGTAAAGAATCACAGC
CAGCGACCAGCAACAGAACAATTGATGAAGCATCCATTTATACGAGACCAACCTAATGAGCGACAGGTCCGCATTCAACTCAAGGACCAT
ATTGATAGAACAAAGAAGAAGCGAGGAGAAAAAGATGAGACAGAGTATGAGTACAGTGGAAGTGAGGAAGAAGAGGAGGAGAATGACTCA
GGAGAGCCCAGCTCCATCCTGAATCTGCCAGGGGAGTCGACGCTGCGGAGGGACTTTCTGAGGCTGCAGCTGGCCAACAAGGAGCGTTCT
GAGGCCCTACGGAGGCAGCAGCTGGAGCAGCAGCAGCGGGAGAATGAGGAGCACAAGCGGCAGCTGCTGGCCGAGCGTCAGAAGCGCATC
GAGGAGCAGAAAGAGCAGAGGCGGCGGCTGGAGGAGCAACAAAGGCGAGAGAAGGAGCTGCGGAAGCAGCAGGAGAGGGAGCAGCGCCGG
CACTATGAGGAGCAGATGCGCCGGGAGGAGGAGAGGAGGCGTGCGGAGCATGAACAGGAATATAAGCGCAAACAATTGGAAGAACAGAGA
CAAGCAGAAAGACTGCAGAGGCAGCTAAAGCAAGAAAGAGACTACTTAGTTTCCCTTCAGCATCAGCGGCAGGAGCAGAGGCCTGTGGAG
AAGAAGCCACTGTACCATTACAAAGAAGGAATGAGTCCTAGTGAGAAGCCAGCATGGGCCAAGGAGATCCCACATCTGGTAGCTGTAAAA
TCCCAGGGACCTGCCTTGACCGCCTCCCAGTCAGTGCACGAGCAGCCCACAAAGGGCCTCTCTGGGTTTCAGGAGGCTCTGAACGTGACC
TCCCACCGCGTGGAGATGCCACGCCAGAACTCAGATCCCACCTCGGAAAATCCTCCTCTCCCCACTCGCATTGAAAAGTTTGACCGAAGC
TCTTGGTTACGACAGGAAGAAGACATTCCACCAAAGGTGCCTCAAAGAACAACTTCTATATCCCCAGCATTAGCCAGAAAGAATTCTCCT
GGGAATGGTAGTGCTCTGGGACCCAGACTAGGATCTCAACCCATCAGAGCAAGCAACCCTGATCTCCGGAGAACTGAGCCCATCTTGGAG
AGCCCCTTGCAGAGGACCAGCAGTGGCAGTTCCTCCAGCTCCAGCACCCCTAGCTCCCAGCCCAGCTCCCAAGGAGGCTCCCAGCCTGGA
TCACAAGCAGGATCCAGTGAACGCACCAGAGTTCGAGCCAACAGTAAGTCAGAAGGATCACCTGTGCTCCCCCATGAGCCTGCGAAGGTG
AAACCAGAAGAATCCAGGGACATTACCCGGCCCAGTCGACCAGCTAGCTACAAAAAAGCTATAGATGAGGAATAAGAAGATGATGAAAAG
ATTAATGACAGTAGAGAAGTAGCAGCAACCTGTTTGAATACAATGTACTAAAGGAGGGATGTACTTTCAGATCATGTAACCTATTACGAA
GGAGTGGAAGAGGAGACAATTTGAATGAATCCTCATGATCTACAAAACAAAATCATAGTGACTAGGACTCCACAGTGAAGATGGTTGACT

>92691_92691_1_TNIK-DPPA2_TNIK_chr3_170824971_ENST00000341852_DPPA2_chr3_109019282_ENST00000478945_length(amino acids)=729AA_BP=
MVHFSSEEVDMASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHR
NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLV
DFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSK
KFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTL
RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRA
EHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQ
PTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPI
RASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA

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>92691_92691_2_TNIK-DPPA2_TNIK_chr3_170824971_ENST00000357327_DPPA2_chr3_109019282_ENST00000478945_length(transcript)=2601nt_BP=2319nt
ATGGCGAGCGACTCCCCGGCTCGAAGCCTGGATGAAATAGATCTCTCGGCTCTGAGGGACCCCGCAGGGATCTTTGAATTGGTGGAACTT
GTTGGAAATGGAACATACGGGCAAGTTTATAAGGGTCGTCATGTCAAAACGGGCCAGCTTGCAGCCATCAAGGTTATGGATGTCACAGGG
GATGAAGAGGAAGAAATCAAACAAGAAATTAACATGTTGAAGAAATATTCTCATCACCGGAATATTGCTACATACTATGGTGCTTTTATC
AAAAAGAACCCACCAGGCATGGATGACCAACTTTGGTTGGTGATGGAGTTTTGTGGTGCTGGCTCTGTCACCGACCTGATCAAGAACACA
AAAGGTAACACGTTGAAAGAGGAGTGGATTGCATACATCTGCAGGGAAATCTTACGGGGGCTGAGTCACCTGCACCAGCATAAAGTGATT
CATCGAGATATTAAAGGGCAAAATGTCTTGCTGACTGAAAATGCAGAAGTTAAACTAGTGGACTTTGGAGTCAGTGCTCAGCTTGATCGA
ACAGTGGGCAGGAGGAATACTTTCATTGGAACTCCCTACTGGATGGCACCAGAAGTTATTGCCTGTGATGAAAACCCAGATGCCACATAT
GATTTCAAGAGTGACTTGTGGTCTTTGGGTATCACCGCCATTGAAATGGCAGAAGGTGCTCCCCCTCTCTGTGACATGCACCCCATGAGA
GCTCTCTTCCTCATCCCCCGGAACCCAGCGCCTCGGCTGAAGTCTAAGAAGTGGTCAAAAAAATTCCAGTCATTTATTGAGAGCTGCTTG
GTAAAGAATCACAGCCAGCGACCAGCAACAGAACAATTGATGAAGCATCCATTTATACGAGACCAACCTAATGAGCGACAGGTCCGCATT
CAACTCAAGGACCATATTGATAGAACAAAGAAGAAGCGAGGAGAAAAAGATGAGACAGAGTATGAGTACAGTGGAAGTGAGGAAGAAGAG
GAGGAGAATGACTCAGGAGAGCCCAGCTCCATCCTGAATCTGCCAGGGGAGTCGACGCTGCGGAGGGACTTTCTGAGGCTGCAGCTGGCC
AACAAGGAGCGTTCTGAGGCCCTACGGAGGCAGCAGCTGGAGCAGCAGCAGCGGGAGAATGAGGAGCACAAGCGGCAGCTGCTGGCCGAG
CGTCAGAAGCGCATCGAGGAGCAGAAAGAGCAGAGGCGGCGGCTGGAGGAGCAACAAAGGCGAGAGAAGGAGCTGCGGAAGCAGCAGGAG
AGGGAGCAGCGCCGGCACTATGAGGAGCAGATGCGCCGGGAGGAGGAGAGGAGGCGTGCGGAGCATGAACAGGAATATAAGCGCAAACAA
TTGGAAGAACAGAGACAAGCAGAAAGACTGCAGAGGCAGCTAAAGCAAGAAAGAGACTACTTAGTTTCCCTTCAGCATCAGCGGCAGGAG
CAGAGGCCTGTGGAGAAGAAGCCACTGTACCATTACAAAGAAGGAATGAGTCCTAGTGAGAAGCCAGCATGGGCCAAGGAGGTAGAAGAA
CGGTCAAGGCTCAACCGGCAAAGTTCCCCTGCCATGCCTCACAAGGTTGCCAACAGGATATCTGACCCCAACCTGCCCCCAAGGTCGGAG
TCCTTCAGCATTAGTGGAGTTCAGCCTGCTCGAACACCCCCCATGCTCAGACCAGTCGATCCCCAGATCCCACATCTGGTAGCTGTAAAA
TCCCAGGGACCTGCCTTGACCGCCTCCCAGTCAGTGCACGAGCAGCCCACAAAGGGCCTCTCTGGGTTTCAGGAGGCTCTGAACGTGACC
TCCCACCGCGTGGAGATGCCACGCCAGAACTCAGATCCCACCTCGGAAAATCCTCCTCTCCCCACTCGCATTGAAAAGTTTGACCGAAGC
TCTTGGTTACGACAGGAAGAAGACATTCCACCAAAGGTGCCTCAAAGAACAACTTCTATATCCCCAGCATTAGCCAGAAAGAATTCTCCT
GGGAATGGTAGTGCTCTGGGACCCAGACTAGGATCTCAACCCATCAGAGCAAGCAACCCTGATCTCCGGAGAACTGAGCCCATCTTGGAG
AGCCCCTTGCAGAGGACCAGCAGTGGCAGTTCCTCCAGCTCCAGCACCCCTAGCTCCCAGCCCAGCTCCCAAGGAGGCTCCCAGCCTGGA
TCACAAGCAGGATCCAGTGAACGCACCAGAGTTCGAGCCAACAGTAAGTCAGAAGGATCACCTGTGCTCCCCCATGAGCCTGCGAAGGTG
AAACCAGAAGAATCCAGGGACATTACCCGGCCCAGTCGACCAGCTAGCTACAAAAAAGCTATAGATGAGGAATAAGAAGATGATGAAAAG
ATTAATGACAGTAGAGAAGTAGCAGCAACCTGTTTGAATACAATGTACTAAAGGAGGGATGTACTTTCAGATCATGTAACCTATTACGAA
GGAGTGGAAGAGGAGACAATTTGAATGAATCCTCATGATCTACAAAACAAAATCATAGTGACTAGGACTCCACAGTGAAGATGGTTGACT

>92691_92691_2_TNIK-DPPA2_TNIK_chr3_170824971_ENST00000357327_DPPA2_chr3_109019282_ENST00000478945_length(amino acids)=774AA_BP=
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFI
KKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCL
VKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQ
LEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE
SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRS
SWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG

--------------------------------------------------------------
>92691_92691_3_TNIK-DPPA2_TNIK_chr3_170824971_ENST00000436636_DPPA2_chr3_109019282_ENST00000478945_length(transcript)=3033nt_BP=2751nt
ATTATAACAGCCAATGCAGCCGCCATCCACGCACAAGCAAAGAAGCATGTCCCATTTAAATACACCCACGCAGCCCCAGCGCCCTTAGCC
GATCGGGGCGCTCAGCCCACACGCACCGCTGCTCGGGGCTTGGAGATCCGCGCAGGCTGGGCTCCCGGACCCGGCGGACCGACGCGCGGA
GGATCGGGATCCGGCGCTGTGGGGCTGGGGTGGGCGGGGGAGGCTGGGCCCGGGGCCTCTGGCGCGACACCCGCATGAGGACGCGAGTGA
AATAGACCAAGGTGGAATTTCCAAGGGAAAAGCTTCGGGGTGGTTTTGGTCCATTTCTCCAGCGAAGAAGTAGACATGGCGAGCGACTCC
CCGGCTCGAAGCCTGGATGAAATAGATCTCTCGGCTCTGAGGGACCCCGCAGGGATCTTTGAATTGGTGGAACTTGTTGGAAATGGAACA
TACGGGCAAGTTTATAAGGGTCGTCATGTCAAAACGGGCCAGCTTGCAGCCATCAAGGTTATGGATGTCACAGGGGATGAAGAGGAAGAA
ATCAAACAAGAAATTAACATGTTGAAGAAATATTCTCATCACCGGAATATTGCTACATACTATGGTGCTTTTATCAAAAAGAACCCACCA
GGCATGGATGACCAACTTTGGTTGGTGATGGAGTTTTGTGGTGCTGGCTCTGTCACCGACCTGATCAAGAACACAAAAGGTAACACGTTG
AAAGAGGAGTGGATTGCATACATCTGCAGGGAAATCTTACGGGGGCTGAGTCACCTGCACCAGCATAAAGTGATTCATCGAGATATTAAA
GGGCAAAATGTCTTGCTGACTGAAAATGCAGAAGTTAAACTAGTGGACTTTGGAGTCAGTGCTCAGCTTGATCGAACAGTGGGCAGGAGG
AATACTTTCATTGGAACTCCCTACTGGATGGCACCAGAAGTTATTGCCTGTGATGAAAACCCAGATGCCACATATGATTTCAAGAGTGAC
TTGTGGTCTTTGGGTATCACCGCCATTGAAATGGCAGAAGGTGCTCCCCCTCTCTGTGACATGCACCCCATGAGAGCTCTCTTCCTCATC
CCCCGGAACCCAGCGCCTCGGCTGAAGTCTAAGAAGTGGTCAAAAAAATTCCAGTCATTTATTGAGAGCTGCTTGGTAAAGAATCACAGC
CAGCGACCAGCAACAGAACAATTGATGAAGCATCCATTTATACGAGACCAACCTAATGAGCGACAGGTCCGCATTCAACTCAAGGACCAT
ATTGATAGAACAAAGAAGAAGCGAGGAGAAAAAGATGAGACAGAGTATGAGTACAGTGGAAGTGAGGAAGAAGAGGAGGAGAATGACTCA
GGAGAGCCCAGCTCCATCCTGAATCTGCCAGGGGAGTCGACGCTGCGGAGGGACTTTCTGAGGCTGCAGCTGGCCAACAAGGAGCGTTCT
GAGGCCCTACGGAGGCAGCAGCTGGAGCAGCAGCAGCGGGAGAATGAGGAGCACAAGCGGCAGCTGCTGGCCGAGCGTCAGAAGCGCATC
GAGGAGCAGAAAGAGCAGAGGCGGCGGCTGGAGGAGCAACAAAGGCGAGAGAAGGAGCTGCGGAAGCAGCAGGAGAGGGAGCAGCGCCGG
CACTATGAGGAGCAGATGCGCCGGGAGGAGGAGAGGAGGCGTGCGGAGCATGAACAGGAATACATCAGGCGACAGTTAGAGGAGGAGCAG
AGACAGTTAGAGATCTTGCAGCAGCAGCTACTGCATGAACAAGCTCTACTTCTGGAATATAAGCGCAAACAATTGGAAGAACAGAGACAA
GCAGAAAGACTGCAGAGGCAGCTAAAGCAAGAAAGAGACTACTTAGTTTCCCTTCAGCATCAGCGGCAGGAGCAGAGGCCTGTGGAGAAG
AAGCCACTGTACCATTACAAAGAAGGAATGAGTCCTAGTGAGAAGCCAGCATGGGCCAAGGAGGTAGAAGAACGGTCAAGGCTCAACCGG
CAAAGTTCCCCTGCCATGCCTCACAAGGTTGCCAACAGGATATCTGACCCCAACCTGCCCCCAAGGTCGGAGTCCTTCAGCATTAGTGGA
GTTCAGCCTGCTCGAACACCCCCCATGCTCAGACCAGTCGATCCCCAGATCCCACATCTGGTAGCTGTAAAATCCCAGGGACCTGCCTTG
ACCGCCTCCCAGTCAGTGCACGAGCAGCCCACAAAGGGCCTCTCTGGGTTTCAGGAGGCTCTGAACGTGACCTCCCACCGCGTGGAGATG
CCACGCCAGAACTCAGATCCCACCTCGGAAAATCCTCCTCTCCCCACTCGCATTGAAAAGTTTGACCGAAGCTCTTGGTTACGACAGGAA
GAAGACATTCCACCAAAGGTGCCTCAAAGAACAACTTCTATATCCCCAGCATTAGCCAGAAAGAATTCTCCTGGGAATGGTAGTGCTCTG
GGACCCAGACTAGGATCTCAACCCATCAGAGCAAGCAACCCTGATCTCCGGAGAACTGAGCCCATCTTGGAGAGCCCCTTGCAGAGGACC
AGCAGTGGCAGTTCCTCCAGCTCCAGCACCCCTAGCTCCCAGCCCAGCTCCCAAGGAGGCTCCCAGCCTGGATCACAAGCAGGATCCAGT
GAACGCACCAGAGTTCGAGCCAACAGTAAGTCAGAAGGATCACCTGTGCTCCCCCATGAGCCTGCGAAGGTGAAACCAGAAGAATCCAGG
GACATTACCCGGCCCAGTCGACCAGCTAGCTACAAAAAAGCTATAGATGAGGAATAAGAAGATGATGAAAAGATTAATGACAGTAGAGAA
GTAGCAGCAACCTGTTTGAATACAATGTACTAAAGGAGGGATGTACTTTCAGATCATGTAACCTATTACGAAGGAGTGGAAGAGGAGACA
ATTTGAATGAATCCTCATGATCTACAAAACAAAATCATAGTGACTAGGACTCCACAGTGAAGATGGTTGACTAGTGACACAGCCCCATCT

>92691_92691_3_TNIK-DPPA2_TNIK_chr3_170824971_ENST00000436636_DPPA2_chr3_109019282_ENST00000478945_length(amino acids)=813AA_BP=
MVHFSSEEVDMASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHR
NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLV
DFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSK
KFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTL
RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRA
EHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEK
PAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLS
GFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPD
LRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAI

--------------------------------------------------------------
>92691_92691_4_TNIK-DPPA2_TNIK_chr3_170824971_ENST00000488470_DPPA2_chr3_109019282_ENST00000478945_length(transcript)=2523nt_BP=2241nt
ATGGCGAGCGACTCCCCGGCTCGAAGCCTGGATGAAATAGATCTCTCGGCTCTGAGGGACCCCGCAGGGATCTTTGAATTGGTGGAACTT
GTTGGAAATGGAACATACGGGCAAGTTTATAAGGGTCGTCATGTCAAAACGGGCCAGCTTGCAGCCATCAAGGTTATGGATGTCACAGGG
GATGAAGAGGAAGAAATCAAACAAGAAATTAACATGTTGAAGAAATATTCTCATCACCGGAATATTGCTACATACTATGGTGCTTTTATC
AAAAAGAACCCACCAGGCATGGATGACCAACTTTGGTTGGTGATGGAGTTTTGTGGTGCTGGCTCTGTCACCGACCTGATCAAGAACACA
AAAGGTAACACGTTGAAAGAGGAGTGGATTGCATACATCTGCAGGGAAATCTTACGGGGGCTGAGTCACCTGCACCAGCATAAAGTGATT
CATCGAGATATTAAAGGGCAAAATGTCTTGCTGACTGAAAATGCAGAAGTTAAACTAGTGGACTTTGGAGTCAGTGCTCAGCTTGATCGA
ACAGTGGGCAGGAGGAATACTTTCATTGGAACTCCCTACTGGATGGCACCAGAAGTTATTGCCTGTGATGAAAACCCAGATGCCACATAT
GATTTCAAGAGTGACTTGTGGTCTTTGGGTATCACCGCCATTGAAATGGCAGAAGGTGCTCCCCCTCTCTGTGACATGCACCCCATGAGA
GCTCTCTTCCTCATCCCCCGGAACCCAGCGCCTCGGCTGAAGTCTAAGAAGTGGTCAAAAAAATTCCAGTCATTTATTGAGAGCTGCTTG
GTAAAGAATCACAGCCAGCGACCAGCAACAGAACAATTGATGAAGCATCCATTTATACGAGACCAACCTAATGAGCGACAGGTCCGCATT
CAACTCAAGGACCATATTGATAGAACAAAGAAGAAGCGAGGAGAAAAAGATGAGACAGAGTATGAGTACAGTGGAAGTGAGGAAGAAGAG
GAGGAGAATGACTCAGGAGAGCCCAGCTCCATCCTGAATCTGCCAGGGGAGTCGACGCTGCGGAGGGACTTTCTGAGGCTGCAGCTGGCC
AACAAGGAGCGTTCTGAGGCCCTACGGAGGCAGCAGCTGGAGCAGCAGCAGCGGGAGAATGAGGAGCACAAGCGGCAGCTGCTGGCCGAG
CGTCAGAAGCGCATCGAGGAGCAGAAAGAGCAGAGGCGGCGGCTGGAGGAGCAACAAAGGCGAGAGAAGGAGCTGCGGAAGCAGCAGGAG
AGGGAGCAGCGCCGGCACTATGAGGAGCAGATGCGCCGGGAGGAGGAGAGGAGGCGTGCGGAGCATGAACAGGAATACATCAGGCGACAG
TTAGAGGAGGAGCAGAGACAGTTAGAGATCTTGCAGCAGCAGCTACTGCATGAACAAGCTCTACTTCTGGAATATAAGCGCAAACAATTG
GAAGAACAGAGACAAGCAGAAAGACTGCAGAGGCAGCTAAAGCAAGAAAGAGACTACTTAGTTTCCCTTCAGCATCAGCGGCAGGAGCAG
AGGCCTGTGGAGAAGAAGCCACTGTACCATTACAAAGAAGGAATGAGTCCTAGTGAGAAGCCAGCATGGGCCAAGGAGATCCCACATCTG
GTAGCTGTAAAATCCCAGGGACCTGCCTTGACCGCCTCCCAGTCAGTGCACGAGCAGCCCACAAAGGGCCTCTCTGGGTTTCAGGAGGCT
CTGAACGTGACCTCCCACCGCGTGGAGATGCCACGCCAGAACTCAGATCCCACCTCGGAAAATCCTCCTCTCCCCACTCGCATTGAAAAG
TTTGACCGAAGCTCTTGGTTACGACAGGAAGAAGACATTCCACCAAAGGTGCCTCAAAGAACAACTTCTATATCCCCAGCATTAGCCAGA
AAGAATTCTCCTGGGAATGGTAGTGCTCTGGGACCCAGACTAGGATCTCAACCCATCAGAGCAAGCAACCCTGATCTCCGGAGAACTGAG
CCCATCTTGGAGAGCCCCTTGCAGAGGACCAGCAGTGGCAGTTCCTCCAGCTCCAGCACCCCTAGCTCCCAGCCCAGCTCCCAAGGAGGC
TCCCAGCCTGGATCACAAGCAGGATCCAGTGAACGCACCAGAGTTCGAGCCAACAGTAAGTCAGAAGGATCACCTGTGCTCCCCCATGAG
CCTGCGAAGGTGAAACCAGAAGAATCCAGGGACATTACCCGGCCCAGTCGACCAGCTAGCTACAAAAAAGCTATAGATGAGGAATAAGAA
GATGATGAAAAGATTAATGACAGTAGAGAAGTAGCAGCAACCTGTTTGAATACAATGTACTAAAGGAGGGATGTACTTTCAGATCATGTA
ACCTATTACGAAGGAGTGGAAGAGGAGACAATTTGAATGAATCCTCATGATCTACAAAACAAAATCATAGTGACTAGGACTCCACAGTGA
AGATGGTTGACTAGTGACACAGCCCCATCTAAAGAATCCCTTTCTGTATGTCTGAAAACCCATTAAAATAAAGTCACTGCAATTGGCCTT

>92691_92691_4_TNIK-DPPA2_TNIK_chr3_170824971_ENST00000488470_DPPA2_chr3_109019282_ENST00000478945_length(amino acids)=748AA_BP=
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFI
KKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCL
VKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQ
LEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHL
VAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALAR
KNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE

--------------------------------------------------------------
>92691_92691_5_TNIK-DPPA2_TNIK_chr3_170824972_ENST00000341852_DPPA2_chr3_109019282_ENST00000478945_length(transcript)=2781nt_BP=2499nt
ATTATAACAGCCAATGCAGCCGCCATCCACGCACAAGCAAAGAAGCATGTCCCATTTAAATACACCCACGCAGCCCCAGCGCCCTTAGCC
GATCGGGGCGCTCAGCCCACACGCACCGCTGCTCGGGGCTTGGAGATCCGCGCAGGCTGGGCTCCCGGACCCGGCGGACCGACGCGCGGA
GGATCGGGATCCGGCGCTGTGGGGCTGGGGTGGGCGGGGGAGGCTGGGCCCGGGGCCTCTGGCGCGACACCCGCATGAGGACGCGAGTGA
AATAGACCAAGGTGGAATTTCCAAGGGAAAAGCTTCGGGGTGGTTTTGGTCCATTTCTCCAGCGAAGAAGTAGACATGGCGAGCGACTCC
CCGGCTCGAAGCCTGGATGAAATAGATCTCTCGGCTCTGAGGGACCCCGCAGGGATCTTTGAATTGGTGGAACTTGTTGGAAATGGAACA
TACGGGCAAGTTTATAAGGGTCGTCATGTCAAAACGGGCCAGCTTGCAGCCATCAAGGTTATGGATGTCACAGGGGATGAAGAGGAAGAA
ATCAAACAAGAAATTAACATGTTGAAGAAATATTCTCATCACCGGAATATTGCTACATACTATGGTGCTTTTATCAAAAAGAACCCACCA
GGCATGGATGACCAACTTTGGTTGGTGATGGAGTTTTGTGGTGCTGGCTCTGTCACCGACCTGATCAAGAACACAAAAGGTAACACGTTG
AAAGAGGAGTGGATTGCATACATCTGCAGGGAAATCTTACGGGGGCTGAGTCACCTGCACCAGCATAAAGTGATTCATCGAGATATTAAA
GGGCAAAATGTCTTGCTGACTGAAAATGCAGAAGTTAAACTAGTGGACTTTGGAGTCAGTGCTCAGCTTGATCGAACAGTGGGCAGGAGG
AATACTTTCATTGGAACTCCCTACTGGATGGCACCAGAAGTTATTGCCTGTGATGAAAACCCAGATGCCACATATGATTTCAAGAGTGAC
TTGTGGTCTTTGGGTATCACCGCCATTGAAATGGCAGAAGGTGCTCCCCCTCTCTGTGACATGCACCCCATGAGAGCTCTCTTCCTCATC
CCCCGGAACCCAGCGCCTCGGCTGAAGTCTAAGAAGTGGTCAAAAAAATTCCAGTCATTTATTGAGAGCTGCTTGGTAAAGAATCACAGC
CAGCGACCAGCAACAGAACAATTGATGAAGCATCCATTTATACGAGACCAACCTAATGAGCGACAGGTCCGCATTCAACTCAAGGACCAT
ATTGATAGAACAAAGAAGAAGCGAGGAGAAAAAGATGAGACAGAGTATGAGTACAGTGGAAGTGAGGAAGAAGAGGAGGAGAATGACTCA
GGAGAGCCCAGCTCCATCCTGAATCTGCCAGGGGAGTCGACGCTGCGGAGGGACTTTCTGAGGCTGCAGCTGGCCAACAAGGAGCGTTCT
GAGGCCCTACGGAGGCAGCAGCTGGAGCAGCAGCAGCGGGAGAATGAGGAGCACAAGCGGCAGCTGCTGGCCGAGCGTCAGAAGCGCATC
GAGGAGCAGAAAGAGCAGAGGCGGCGGCTGGAGGAGCAACAAAGGCGAGAGAAGGAGCTGCGGAAGCAGCAGGAGAGGGAGCAGCGCCGG
CACTATGAGGAGCAGATGCGCCGGGAGGAGGAGAGGAGGCGTGCGGAGCATGAACAGGAATATAAGCGCAAACAATTGGAAGAACAGAGA
CAAGCAGAAAGACTGCAGAGGCAGCTAAAGCAAGAAAGAGACTACTTAGTTTCCCTTCAGCATCAGCGGCAGGAGCAGAGGCCTGTGGAG
AAGAAGCCACTGTACCATTACAAAGAAGGAATGAGTCCTAGTGAGAAGCCAGCATGGGCCAAGGAGATCCCACATCTGGTAGCTGTAAAA
TCCCAGGGACCTGCCTTGACCGCCTCCCAGTCAGTGCACGAGCAGCCCACAAAGGGCCTCTCTGGGTTTCAGGAGGCTCTGAACGTGACC
TCCCACCGCGTGGAGATGCCACGCCAGAACTCAGATCCCACCTCGGAAAATCCTCCTCTCCCCACTCGCATTGAAAAGTTTGACCGAAGC
TCTTGGTTACGACAGGAAGAAGACATTCCACCAAAGGTGCCTCAAAGAACAACTTCTATATCCCCAGCATTAGCCAGAAAGAATTCTCCT
GGGAATGGTAGTGCTCTGGGACCCAGACTAGGATCTCAACCCATCAGAGCAAGCAACCCTGATCTCCGGAGAACTGAGCCCATCTTGGAG
AGCCCCTTGCAGAGGACCAGCAGTGGCAGTTCCTCCAGCTCCAGCACCCCTAGCTCCCAGCCCAGCTCCCAAGGAGGCTCCCAGCCTGGA
TCACAAGCAGGATCCAGTGAACGCACCAGAGTTCGAGCCAACAGTAAGTCAGAAGGATCACCTGTGCTCCCCCATGAGCCTGCGAAGGTG
AAACCAGAAGAATCCAGGGACATTACCCGGCCCAGTCGACCAGCTAGCTACAAAAAAGCTATAGATGAGGAATAAGAAGATGATGAAAAG
ATTAATGACAGTAGAGAAGTAGCAGCAACCTGTTTGAATACAATGTACTAAAGGAGGGATGTACTTTCAGATCATGTAACCTATTACGAA
GGAGTGGAAGAGGAGACAATTTGAATGAATCCTCATGATCTACAAAACAAAATCATAGTGACTAGGACTCCACAGTGAAGATGGTTGACT

>92691_92691_5_TNIK-DPPA2_TNIK_chr3_170824972_ENST00000341852_DPPA2_chr3_109019282_ENST00000478945_length(amino acids)=729AA_BP=
MVHFSSEEVDMASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHR
NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLV
DFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSK
KFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTL
RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRA
EHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQ
PTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPI
RASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA

--------------------------------------------------------------
>92691_92691_6_TNIK-DPPA2_TNIK_chr3_170824972_ENST00000357327_DPPA2_chr3_109019282_ENST00000478945_length(transcript)=2601nt_BP=2319nt
ATGGCGAGCGACTCCCCGGCTCGAAGCCTGGATGAAATAGATCTCTCGGCTCTGAGGGACCCCGCAGGGATCTTTGAATTGGTGGAACTT
GTTGGAAATGGAACATACGGGCAAGTTTATAAGGGTCGTCATGTCAAAACGGGCCAGCTTGCAGCCATCAAGGTTATGGATGTCACAGGG
GATGAAGAGGAAGAAATCAAACAAGAAATTAACATGTTGAAGAAATATTCTCATCACCGGAATATTGCTACATACTATGGTGCTTTTATC
AAAAAGAACCCACCAGGCATGGATGACCAACTTTGGTTGGTGATGGAGTTTTGTGGTGCTGGCTCTGTCACCGACCTGATCAAGAACACA
AAAGGTAACACGTTGAAAGAGGAGTGGATTGCATACATCTGCAGGGAAATCTTACGGGGGCTGAGTCACCTGCACCAGCATAAAGTGATT
CATCGAGATATTAAAGGGCAAAATGTCTTGCTGACTGAAAATGCAGAAGTTAAACTAGTGGACTTTGGAGTCAGTGCTCAGCTTGATCGA
ACAGTGGGCAGGAGGAATACTTTCATTGGAACTCCCTACTGGATGGCACCAGAAGTTATTGCCTGTGATGAAAACCCAGATGCCACATAT
GATTTCAAGAGTGACTTGTGGTCTTTGGGTATCACCGCCATTGAAATGGCAGAAGGTGCTCCCCCTCTCTGTGACATGCACCCCATGAGA
GCTCTCTTCCTCATCCCCCGGAACCCAGCGCCTCGGCTGAAGTCTAAGAAGTGGTCAAAAAAATTCCAGTCATTTATTGAGAGCTGCTTG
GTAAAGAATCACAGCCAGCGACCAGCAACAGAACAATTGATGAAGCATCCATTTATACGAGACCAACCTAATGAGCGACAGGTCCGCATT
CAACTCAAGGACCATATTGATAGAACAAAGAAGAAGCGAGGAGAAAAAGATGAGACAGAGTATGAGTACAGTGGAAGTGAGGAAGAAGAG
GAGGAGAATGACTCAGGAGAGCCCAGCTCCATCCTGAATCTGCCAGGGGAGTCGACGCTGCGGAGGGACTTTCTGAGGCTGCAGCTGGCC
AACAAGGAGCGTTCTGAGGCCCTACGGAGGCAGCAGCTGGAGCAGCAGCAGCGGGAGAATGAGGAGCACAAGCGGCAGCTGCTGGCCGAG
CGTCAGAAGCGCATCGAGGAGCAGAAAGAGCAGAGGCGGCGGCTGGAGGAGCAACAAAGGCGAGAGAAGGAGCTGCGGAAGCAGCAGGAG
AGGGAGCAGCGCCGGCACTATGAGGAGCAGATGCGCCGGGAGGAGGAGAGGAGGCGTGCGGAGCATGAACAGGAATATAAGCGCAAACAA
TTGGAAGAACAGAGACAAGCAGAAAGACTGCAGAGGCAGCTAAAGCAAGAAAGAGACTACTTAGTTTCCCTTCAGCATCAGCGGCAGGAG
CAGAGGCCTGTGGAGAAGAAGCCACTGTACCATTACAAAGAAGGAATGAGTCCTAGTGAGAAGCCAGCATGGGCCAAGGAGGTAGAAGAA
CGGTCAAGGCTCAACCGGCAAAGTTCCCCTGCCATGCCTCACAAGGTTGCCAACAGGATATCTGACCCCAACCTGCCCCCAAGGTCGGAG
TCCTTCAGCATTAGTGGAGTTCAGCCTGCTCGAACACCCCCCATGCTCAGACCAGTCGATCCCCAGATCCCACATCTGGTAGCTGTAAAA
TCCCAGGGACCTGCCTTGACCGCCTCCCAGTCAGTGCACGAGCAGCCCACAAAGGGCCTCTCTGGGTTTCAGGAGGCTCTGAACGTGACC
TCCCACCGCGTGGAGATGCCACGCCAGAACTCAGATCCCACCTCGGAAAATCCTCCTCTCCCCACTCGCATTGAAAAGTTTGACCGAAGC
TCTTGGTTACGACAGGAAGAAGACATTCCACCAAAGGTGCCTCAAAGAACAACTTCTATATCCCCAGCATTAGCCAGAAAGAATTCTCCT
GGGAATGGTAGTGCTCTGGGACCCAGACTAGGATCTCAACCCATCAGAGCAAGCAACCCTGATCTCCGGAGAACTGAGCCCATCTTGGAG
AGCCCCTTGCAGAGGACCAGCAGTGGCAGTTCCTCCAGCTCCAGCACCCCTAGCTCCCAGCCCAGCTCCCAAGGAGGCTCCCAGCCTGGA
TCACAAGCAGGATCCAGTGAACGCACCAGAGTTCGAGCCAACAGTAAGTCAGAAGGATCACCTGTGCTCCCCCATGAGCCTGCGAAGGTG
AAACCAGAAGAATCCAGGGACATTACCCGGCCCAGTCGACCAGCTAGCTACAAAAAAGCTATAGATGAGGAATAAGAAGATGATGAAAAG
ATTAATGACAGTAGAGAAGTAGCAGCAACCTGTTTGAATACAATGTACTAAAGGAGGGATGTACTTTCAGATCATGTAACCTATTACGAA
GGAGTGGAAGAGGAGACAATTTGAATGAATCCTCATGATCTACAAAACAAAATCATAGTGACTAGGACTCCACAGTGAAGATGGTTGACT

>92691_92691_6_TNIK-DPPA2_TNIK_chr3_170824972_ENST00000357327_DPPA2_chr3_109019282_ENST00000478945_length(amino acids)=774AA_BP=
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFI
KKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCL
VKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQ
LEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE
SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRS
SWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG

--------------------------------------------------------------
>92691_92691_7_TNIK-DPPA2_TNIK_chr3_170824972_ENST00000436636_DPPA2_chr3_109019282_ENST00000478945_length(transcript)=3033nt_BP=2751nt
ATTATAACAGCCAATGCAGCCGCCATCCACGCACAAGCAAAGAAGCATGTCCCATTTAAATACACCCACGCAGCCCCAGCGCCCTTAGCC
GATCGGGGCGCTCAGCCCACACGCACCGCTGCTCGGGGCTTGGAGATCCGCGCAGGCTGGGCTCCCGGACCCGGCGGACCGACGCGCGGA
GGATCGGGATCCGGCGCTGTGGGGCTGGGGTGGGCGGGGGAGGCTGGGCCCGGGGCCTCTGGCGCGACACCCGCATGAGGACGCGAGTGA
AATAGACCAAGGTGGAATTTCCAAGGGAAAAGCTTCGGGGTGGTTTTGGTCCATTTCTCCAGCGAAGAAGTAGACATGGCGAGCGACTCC
CCGGCTCGAAGCCTGGATGAAATAGATCTCTCGGCTCTGAGGGACCCCGCAGGGATCTTTGAATTGGTGGAACTTGTTGGAAATGGAACA
TACGGGCAAGTTTATAAGGGTCGTCATGTCAAAACGGGCCAGCTTGCAGCCATCAAGGTTATGGATGTCACAGGGGATGAAGAGGAAGAA
ATCAAACAAGAAATTAACATGTTGAAGAAATATTCTCATCACCGGAATATTGCTACATACTATGGTGCTTTTATCAAAAAGAACCCACCA
GGCATGGATGACCAACTTTGGTTGGTGATGGAGTTTTGTGGTGCTGGCTCTGTCACCGACCTGATCAAGAACACAAAAGGTAACACGTTG
AAAGAGGAGTGGATTGCATACATCTGCAGGGAAATCTTACGGGGGCTGAGTCACCTGCACCAGCATAAAGTGATTCATCGAGATATTAAA
GGGCAAAATGTCTTGCTGACTGAAAATGCAGAAGTTAAACTAGTGGACTTTGGAGTCAGTGCTCAGCTTGATCGAACAGTGGGCAGGAGG
AATACTTTCATTGGAACTCCCTACTGGATGGCACCAGAAGTTATTGCCTGTGATGAAAACCCAGATGCCACATATGATTTCAAGAGTGAC
TTGTGGTCTTTGGGTATCACCGCCATTGAAATGGCAGAAGGTGCTCCCCCTCTCTGTGACATGCACCCCATGAGAGCTCTCTTCCTCATC
CCCCGGAACCCAGCGCCTCGGCTGAAGTCTAAGAAGTGGTCAAAAAAATTCCAGTCATTTATTGAGAGCTGCTTGGTAAAGAATCACAGC
CAGCGACCAGCAACAGAACAATTGATGAAGCATCCATTTATACGAGACCAACCTAATGAGCGACAGGTCCGCATTCAACTCAAGGACCAT
ATTGATAGAACAAAGAAGAAGCGAGGAGAAAAAGATGAGACAGAGTATGAGTACAGTGGAAGTGAGGAAGAAGAGGAGGAGAATGACTCA
GGAGAGCCCAGCTCCATCCTGAATCTGCCAGGGGAGTCGACGCTGCGGAGGGACTTTCTGAGGCTGCAGCTGGCCAACAAGGAGCGTTCT
GAGGCCCTACGGAGGCAGCAGCTGGAGCAGCAGCAGCGGGAGAATGAGGAGCACAAGCGGCAGCTGCTGGCCGAGCGTCAGAAGCGCATC
GAGGAGCAGAAAGAGCAGAGGCGGCGGCTGGAGGAGCAACAAAGGCGAGAGAAGGAGCTGCGGAAGCAGCAGGAGAGGGAGCAGCGCCGG
CACTATGAGGAGCAGATGCGCCGGGAGGAGGAGAGGAGGCGTGCGGAGCATGAACAGGAATACATCAGGCGACAGTTAGAGGAGGAGCAG
AGACAGTTAGAGATCTTGCAGCAGCAGCTACTGCATGAACAAGCTCTACTTCTGGAATATAAGCGCAAACAATTGGAAGAACAGAGACAA
GCAGAAAGACTGCAGAGGCAGCTAAAGCAAGAAAGAGACTACTTAGTTTCCCTTCAGCATCAGCGGCAGGAGCAGAGGCCTGTGGAGAAG
AAGCCACTGTACCATTACAAAGAAGGAATGAGTCCTAGTGAGAAGCCAGCATGGGCCAAGGAGGTAGAAGAACGGTCAAGGCTCAACCGG
CAAAGTTCCCCTGCCATGCCTCACAAGGTTGCCAACAGGATATCTGACCCCAACCTGCCCCCAAGGTCGGAGTCCTTCAGCATTAGTGGA
GTTCAGCCTGCTCGAACACCCCCCATGCTCAGACCAGTCGATCCCCAGATCCCACATCTGGTAGCTGTAAAATCCCAGGGACCTGCCTTG
ACCGCCTCCCAGTCAGTGCACGAGCAGCCCACAAAGGGCCTCTCTGGGTTTCAGGAGGCTCTGAACGTGACCTCCCACCGCGTGGAGATG
CCACGCCAGAACTCAGATCCCACCTCGGAAAATCCTCCTCTCCCCACTCGCATTGAAAAGTTTGACCGAAGCTCTTGGTTACGACAGGAA
GAAGACATTCCACCAAAGGTGCCTCAAAGAACAACTTCTATATCCCCAGCATTAGCCAGAAAGAATTCTCCTGGGAATGGTAGTGCTCTG
GGACCCAGACTAGGATCTCAACCCATCAGAGCAAGCAACCCTGATCTCCGGAGAACTGAGCCCATCTTGGAGAGCCCCTTGCAGAGGACC
AGCAGTGGCAGTTCCTCCAGCTCCAGCACCCCTAGCTCCCAGCCCAGCTCCCAAGGAGGCTCCCAGCCTGGATCACAAGCAGGATCCAGT
GAACGCACCAGAGTTCGAGCCAACAGTAAGTCAGAAGGATCACCTGTGCTCCCCCATGAGCCTGCGAAGGTGAAACCAGAAGAATCCAGG
GACATTACCCGGCCCAGTCGACCAGCTAGCTACAAAAAAGCTATAGATGAGGAATAAGAAGATGATGAAAAGATTAATGACAGTAGAGAA
GTAGCAGCAACCTGTTTGAATACAATGTACTAAAGGAGGGATGTACTTTCAGATCATGTAACCTATTACGAAGGAGTGGAAGAGGAGACA
ATTTGAATGAATCCTCATGATCTACAAAACAAAATCATAGTGACTAGGACTCCACAGTGAAGATGGTTGACTAGTGACACAGCCCCATCT

>92691_92691_7_TNIK-DPPA2_TNIK_chr3_170824972_ENST00000436636_DPPA2_chr3_109019282_ENST00000478945_length(amino acids)=813AA_BP=
MVHFSSEEVDMASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHR
NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLV
DFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSK
KFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTL
RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRA
EHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEK
PAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLS
GFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPD
LRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAI

--------------------------------------------------------------
>92691_92691_8_TNIK-DPPA2_TNIK_chr3_170824972_ENST00000488470_DPPA2_chr3_109019282_ENST00000478945_length(transcript)=2523nt_BP=2241nt
ATGGCGAGCGACTCCCCGGCTCGAAGCCTGGATGAAATAGATCTCTCGGCTCTGAGGGACCCCGCAGGGATCTTTGAATTGGTGGAACTT
GTTGGAAATGGAACATACGGGCAAGTTTATAAGGGTCGTCATGTCAAAACGGGCCAGCTTGCAGCCATCAAGGTTATGGATGTCACAGGG
GATGAAGAGGAAGAAATCAAACAAGAAATTAACATGTTGAAGAAATATTCTCATCACCGGAATATTGCTACATACTATGGTGCTTTTATC
AAAAAGAACCCACCAGGCATGGATGACCAACTTTGGTTGGTGATGGAGTTTTGTGGTGCTGGCTCTGTCACCGACCTGATCAAGAACACA
AAAGGTAACACGTTGAAAGAGGAGTGGATTGCATACATCTGCAGGGAAATCTTACGGGGGCTGAGTCACCTGCACCAGCATAAAGTGATT
CATCGAGATATTAAAGGGCAAAATGTCTTGCTGACTGAAAATGCAGAAGTTAAACTAGTGGACTTTGGAGTCAGTGCTCAGCTTGATCGA
ACAGTGGGCAGGAGGAATACTTTCATTGGAACTCCCTACTGGATGGCACCAGAAGTTATTGCCTGTGATGAAAACCCAGATGCCACATAT
GATTTCAAGAGTGACTTGTGGTCTTTGGGTATCACCGCCATTGAAATGGCAGAAGGTGCTCCCCCTCTCTGTGACATGCACCCCATGAGA
GCTCTCTTCCTCATCCCCCGGAACCCAGCGCCTCGGCTGAAGTCTAAGAAGTGGTCAAAAAAATTCCAGTCATTTATTGAGAGCTGCTTG
GTAAAGAATCACAGCCAGCGACCAGCAACAGAACAATTGATGAAGCATCCATTTATACGAGACCAACCTAATGAGCGACAGGTCCGCATT
CAACTCAAGGACCATATTGATAGAACAAAGAAGAAGCGAGGAGAAAAAGATGAGACAGAGTATGAGTACAGTGGAAGTGAGGAAGAAGAG
GAGGAGAATGACTCAGGAGAGCCCAGCTCCATCCTGAATCTGCCAGGGGAGTCGACGCTGCGGAGGGACTTTCTGAGGCTGCAGCTGGCC
AACAAGGAGCGTTCTGAGGCCCTACGGAGGCAGCAGCTGGAGCAGCAGCAGCGGGAGAATGAGGAGCACAAGCGGCAGCTGCTGGCCGAG
CGTCAGAAGCGCATCGAGGAGCAGAAAGAGCAGAGGCGGCGGCTGGAGGAGCAACAAAGGCGAGAGAAGGAGCTGCGGAAGCAGCAGGAG
AGGGAGCAGCGCCGGCACTATGAGGAGCAGATGCGCCGGGAGGAGGAGAGGAGGCGTGCGGAGCATGAACAGGAATACATCAGGCGACAG
TTAGAGGAGGAGCAGAGACAGTTAGAGATCTTGCAGCAGCAGCTACTGCATGAACAAGCTCTACTTCTGGAATATAAGCGCAAACAATTG
GAAGAACAGAGACAAGCAGAAAGACTGCAGAGGCAGCTAAAGCAAGAAAGAGACTACTTAGTTTCCCTTCAGCATCAGCGGCAGGAGCAG
AGGCCTGTGGAGAAGAAGCCACTGTACCATTACAAAGAAGGAATGAGTCCTAGTGAGAAGCCAGCATGGGCCAAGGAGATCCCACATCTG
GTAGCTGTAAAATCCCAGGGACCTGCCTTGACCGCCTCCCAGTCAGTGCACGAGCAGCCCACAAAGGGCCTCTCTGGGTTTCAGGAGGCT
CTGAACGTGACCTCCCACCGCGTGGAGATGCCACGCCAGAACTCAGATCCCACCTCGGAAAATCCTCCTCTCCCCACTCGCATTGAAAAG
TTTGACCGAAGCTCTTGGTTACGACAGGAAGAAGACATTCCACCAAAGGTGCCTCAAAGAACAACTTCTATATCCCCAGCATTAGCCAGA
AAGAATTCTCCTGGGAATGGTAGTGCTCTGGGACCCAGACTAGGATCTCAACCCATCAGAGCAAGCAACCCTGATCTCCGGAGAACTGAG
CCCATCTTGGAGAGCCCCTTGCAGAGGACCAGCAGTGGCAGTTCCTCCAGCTCCAGCACCCCTAGCTCCCAGCCCAGCTCCCAAGGAGGC
TCCCAGCCTGGATCACAAGCAGGATCCAGTGAACGCACCAGAGTTCGAGCCAACAGTAAGTCAGAAGGATCACCTGTGCTCCCCCATGAG
CCTGCGAAGGTGAAACCAGAAGAATCCAGGGACATTACCCGGCCCAGTCGACCAGCTAGCTACAAAAAAGCTATAGATGAGGAATAAGAA
GATGATGAAAAGATTAATGACAGTAGAGAAGTAGCAGCAACCTGTTTGAATACAATGTACTAAAGGAGGGATGTACTTTCAGATCATGTA
ACCTATTACGAAGGAGTGGAAGAGGAGACAATTTGAATGAATCCTCATGATCTACAAAACAAAATCATAGTGACTAGGACTCCACAGTGA
AGATGGTTGACTAGTGACACAGCCCCATCTAAAGAATCCCTTTCTGTATGTCTGAAAACCCATTAAAATAAAGTCACTGCAATTGGCCTT

>92691_92691_8_TNIK-DPPA2_TNIK_chr3_170824972_ENST00000488470_DPPA2_chr3_109019282_ENST00000478945_length(amino acids)=748AA_BP=
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFI
KKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCL
VKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQ
LEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHL
VAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALAR
KNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TNIK-DPPA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TNIK-DPPA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TNIK-DPPA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource