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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TNIK-KCNMB2 (FusionGDB2 ID:92698)

Fusion Gene Summary for TNIK-KCNMB2

check button Fusion gene summary
Fusion gene informationFusion gene name: TNIK-KCNMB2
Fusion gene ID: 92698
HgeneTgene
Gene symbol

TNIK

KCNMB2

Gene ID

23043

27094

Gene nameTRAF2 and NCK interacting kinasepotassium calcium-activated channel subfamily M regulatory beta subunit 3
SynonymsMRT54BKBETA3|HBETA3|K(VCA)BETA-3|KCNMB2|KCNMBL|SLO-BETA-3|SLOBETA3
Cytomap

3q26.2-q26.31

3q26.32

Type of geneprotein-codingprotein-coding
DescriptionTRAF2 and NCK-interacting protein kinasecalcium-activated potassium channel subunit beta-3BK channel beta subunit 3BK channel subunit beta-3MaxiK channel beta-subunit 3big potassium channel beta subunit 3calcium-activated potassium channel regulatory subunitcalcium-activated potassium cha
Modification date2020031320200313
UniProtAcc.

Q9Y691

Ensembl transtripts involved in fusion geneENST00000284483, ENST00000341852, 
ENST00000357327, ENST00000369326, 
ENST00000436636, ENST00000460047, 
ENST00000465393, ENST00000470834, 
ENST00000475336, ENST00000488470, 
ENST00000538048, ENST00000464785, 
ENST00000470361, ENST00000358316, 
ENST00000420517, ENST00000432997, 
ENST00000452583, 
Fusion gene scores* DoF score14 X 13 X 6=10925 X 3 X 5=75
# samples 135
** MAII scorelog2(13/1092*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNIK [Title/Abstract] AND KCNMB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTNIK(171087409)-KCNMB2(178525131), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNIK

GO:0006468

protein phosphorylation

10521462|15342639|22797597

HgeneTNIK

GO:0007256

activation of JNKK activity

15342639

HgeneTNIK

GO:0031532

actin cytoskeleton reorganization

15342639

HgeneTNIK

GO:0035556

intracellular signal transduction

10521462

HgeneTNIK

GO:0046777

protein autophosphorylation

10521462|15342639

HgeneTNIK

GO:0048814

regulation of dendrite morphogenesis

20159449

TgeneKCNMB2

GO:0001508

action potential

10692449

TgeneKCNMB2

GO:0005513

detection of calcium ion

10692449

TgeneKCNMB2

GO:0006813

potassium ion transport

10692449

TgeneKCNMB2

GO:0019228

neuronal action potential

10692449


check buttonFusion gene breakpoints across TNIK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KCNMB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TM-A84B-01ATNIKchr3

171087409

-KCNMB2chr3

178525131

+
ChimerDB4LGGTCGA-TM-A84BTNIKchr3

171087409

-KCNMB2chr3

178525131

+


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Fusion Gene ORF analysis for TNIK-KCNMB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000284483ENST00000470361TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-3UTRENST00000341852ENST00000470361TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-3UTRENST00000357327ENST00000470361TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-3UTRENST00000369326ENST00000470361TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-3UTRENST00000436636ENST00000470361TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-3UTRENST00000460047ENST00000470361TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-3UTRENST00000465393ENST00000470361TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-3UTRENST00000470834ENST00000470361TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-3UTRENST00000475336ENST00000470361TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-3UTRENST00000488470ENST00000470361TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-3UTRENST00000538048ENST00000470361TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000284483ENST00000358316TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000284483ENST00000420517TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000284483ENST00000432997TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000284483ENST00000452583TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000341852ENST00000358316TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000341852ENST00000420517TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000341852ENST00000432997TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000341852ENST00000452583TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000357327ENST00000358316TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000357327ENST00000420517TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000357327ENST00000432997TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000357327ENST00000452583TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000369326ENST00000358316TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000369326ENST00000420517TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000369326ENST00000432997TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000369326ENST00000452583TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000436636ENST00000358316TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000436636ENST00000420517TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000436636ENST00000432997TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000436636ENST00000452583TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000460047ENST00000358316TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000460047ENST00000420517TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000460047ENST00000432997TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000460047ENST00000452583TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000465393ENST00000358316TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000465393ENST00000420517TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000465393ENST00000432997TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000465393ENST00000452583TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000470834ENST00000358316TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000470834ENST00000420517TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000470834ENST00000432997TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000470834ENST00000452583TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000475336ENST00000358316TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000475336ENST00000420517TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000475336ENST00000432997TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000475336ENST00000452583TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000488470ENST00000358316TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000488470ENST00000420517TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000488470ENST00000432997TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000488470ENST00000452583TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000538048ENST00000358316TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000538048ENST00000420517TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000538048ENST00000432997TNIKchr3

171087409

-KCNMB2chr3

178525131

+
5CDS-5UTRENST00000538048ENST00000452583TNIKchr3

171087409

-KCNMB2chr3

178525131

+
intron-3UTRENST00000464785ENST00000470361TNIKchr3

171087409

-KCNMB2chr3

178525131

+
intron-5UTRENST00000464785ENST00000358316TNIKchr3

171087409

-KCNMB2chr3

178525131

+
intron-5UTRENST00000464785ENST00000420517TNIKchr3

171087409

-KCNMB2chr3

178525131

+
intron-5UTRENST00000464785ENST00000432997TNIKchr3

171087409

-KCNMB2chr3

178525131

+
intron-5UTRENST00000464785ENST00000452583TNIKchr3

171087409

-KCNMB2chr3

178525131

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TNIK-KCNMB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TNIKchr3171087408-KCNMB2chr3178525130+5.75E-070.9999994
TNIKchr3171087408-KCNMB2chr3178525130+5.75E-070.9999994
TNIKchr3171087408-KCNMB2chr3178525130+5.75E-070.9999994
TNIKchr3171087408-KCNMB2chr3178525130+5.75E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TNIK-KCNMB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:171087409/:178525131)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KCNMB2

Q9Y691

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. {ECO:0000269|PubMed:10097176, ECO:0000269|PubMed:10377337}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TNIK-KCNMB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TNIK-KCNMB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TNIK-KCNMB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TNIK-KCNMB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource