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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TNIP1-NIPAL4 (FusionGDB2 ID:92708)

Fusion Gene Summary for TNIP1-NIPAL4

Fusion gene summary

Fusion gene information	Fusion gene name: TNIP1-NIPAL4
	Fusion gene ID: 92708
		Hgene	Tgene
	Gene symbol	TNIP1	NIPAL4
	Gene ID	10318	348938
	Gene name	TNFAIP3 interacting protein 1	NIPA like domain containing 4
	Synonyms	ABIN-1\|NAF1\|VAN\|nip40-1	ARCI6\|ICHTHYIN\|ICHYN
	Cytomap	5q33.1	5q33.3
	Type of gene	protein-coding	protein-coding
	Description	TNFAIP3-interacting protein 1A20-binding inhibitor of NF-kappa-B activation 1HIV-1 Nef-interacting proteinNef-associated factor 1 SNPvirion-associated nuclear shuttling protein	magnesium transporter NIPA4NIPA-like protein 4non-imprinted in Prader-Willi/Angelman syndrome region protein 4
	Modification date	20200327	20200327
	UniProtAcc	Q15025	.
	Ensembl transtripts involved in fusion gene	ENST00000315050, ENST00000389378, ENST00000518977, ENST00000520931, ENST00000521591, ENST00000522226, ENST00000523200, ENST00000523338, ENST00000524280, ENST00000521423,	ENST00000521390, ENST00000311946, ENST00000435489,
Fusion gene scores	* DoF score	11 X 10 X 7=770	2 X 1 X 1=2
	# samples	11	1
	** MAII score	log2(11/770*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/2*10)=2.32192809488736
Context	PubMed: TNIP1 [Title/Abstract] AND NIPAL4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TNIP1(150441688)-NIPAL4(156890102), # samples:2
Anticipated loss of major functional domain due to fusion event.	TNIP1-NIPAL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TNIP1-NIPAL4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TNIP1	GO:0009101	glycoprotein biosynthetic process	9923610
Hgene	TNIP1	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	16684768
Hgene	TNIP1	GO:0070373	negative regulation of ERK1 and ERK2 cascade	12220502
Hgene	TNIP1	GO:0085032	modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade	20010814
Hgene	TNIP1	GO:1903003	positive regulation of protein deubiquitination	16684768

Fusion gene breakpoints across TNIP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NIPAL4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRC	TCGA-BP-4986-01A	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+

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Fusion Gene ORF analysis for TNIP1-NIPAL4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000315050	ENST00000521390	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
5CDS-3UTR	ENST00000389378	ENST00000521390	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
5CDS-3UTR	ENST00000518977	ENST00000521390	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
5CDS-3UTR	ENST00000520931	ENST00000521390	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
5CDS-3UTR	ENST00000521591	ENST00000521390	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
5CDS-3UTR	ENST00000522226	ENST00000521390	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
5CDS-3UTR	ENST00000523200	ENST00000521390	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
5CDS-3UTR	ENST00000523338	ENST00000521390	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
5CDS-3UTR	ENST00000524280	ENST00000521390	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
Frame-shift	ENST00000518977	ENST00000311946	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
Frame-shift	ENST00000518977	ENST00000435489	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
Frame-shift	ENST00000521591	ENST00000311946	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
Frame-shift	ENST00000521591	ENST00000435489	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
Frame-shift	ENST00000522226	ENST00000311946	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
Frame-shift	ENST00000522226	ENST00000435489	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
Frame-shift	ENST00000523200	ENST00000311946	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
Frame-shift	ENST00000523200	ENST00000435489	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
Frame-shift	ENST00000524280	ENST00000311946	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
Frame-shift	ENST00000524280	ENST00000435489	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
In-frame	ENST00000315050	ENST00000311946	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
In-frame	ENST00000315050	ENST00000435489	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
In-frame	ENST00000389378	ENST00000311946	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
In-frame	ENST00000389378	ENST00000435489	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
In-frame	ENST00000520931	ENST00000311946	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
In-frame	ENST00000520931	ENST00000435489	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
In-frame	ENST00000523338	ENST00000311946	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
In-frame	ENST00000523338	ENST00000435489	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
intron-3CDS	ENST00000521423	ENST00000311946	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
intron-3CDS	ENST00000521423	ENST00000435489	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+
intron-3UTR	ENST00000521423	ENST00000521390	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000520931	TNIP1	chr5	150441688	-	ENST00000435489	NIPAL4	chr5	156890102	+	1619	358	363	1478	371
ENST00000520931	TNIP1	chr5	150441688	-	ENST00000311946	NIPAL4	chr5	156890102	+	3293	358	363	1535	390
ENST00000389378	TNIP1	chr5	150441688	-	ENST00000435489	NIPAL4	chr5	156890102	+	2207	946	951	2066	371
ENST00000389378	TNIP1	chr5	150441688	-	ENST00000311946	NIPAL4	chr5	156890102	+	3881	946	951	2123	390
ENST00000523338	TNIP1	chr5	150441688	-	ENST00000435489	NIPAL4	chr5	156890102	+	1728	467	472	1587	371
ENST00000523338	TNIP1	chr5	150441688	-	ENST00000311946	NIPAL4	chr5	156890102	+	3402	467	472	1644	390
ENST00000315050	TNIP1	chr5	150441688	-	ENST00000435489	NIPAL4	chr5	156890102	+	1728	467	472	1587	371
ENST00000315050	TNIP1	chr5	150441688	-	ENST00000311946	NIPAL4	chr5	156890102	+	3402	467	472	1644	390

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000520931	ENST00000435489	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+	0.014686422	0.9853136
ENST00000520931	ENST00000311946	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+	0.005537761	0.9944622
ENST00000389378	ENST00000435489	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+	0.019336088	0.9806639
ENST00000389378	ENST00000311946	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+	0.005877899	0.9941221
ENST00000523338	ENST00000435489	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+	0.016560746	0.98343927
ENST00000523338	ENST00000311946	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+	0.005518195	0.9944818
ENST00000315050	ENST00000435489	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+	0.016560746	0.98343927
ENST00000315050	ENST00000311946	TNIP1	chr5	150441688	-	NIPAL4	chr5	156890102	+	0.005518195	0.9944818

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Fusion Genomic Features for TNIP1-NIPAL4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TNIP1	chr5	150441687	-	NIPAL4	chr5	156890101	+	9.12E-05	0.9999088
TNIP1	chr5	150441687	-	NIPAL4	chr5	156890101	+	9.12E-05	0.9999088

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TNIP1-NIPAL4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:150441688/chr5:156890102)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TNIP1 Q15025	.
FUNCTION: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269\|PubMed:12220502, ECO:0000269\|PubMed:16684768, ECO:0000269\|PubMed:17016622, ECO:0000269\|PubMed:17632516, ECO:0000269\|PubMed:20010814}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000315050

20_73

119

637.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000389378

20_73

119

637.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000518977

20_73

119

636.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000521591

20_73

119

637.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000522226

20_73

119

637.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000523338

20_73

119

636.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

139_164

467.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

186_186

467.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

208_215

467.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

237_257

467.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

279_285

467.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

307_323

467.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

345_355

467.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

377_386

467.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

408_466

467.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

139_164

448.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

186_186

448.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

208_215

448.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

237_257

448.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

279_285

448.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

307_323

448.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

345_355

448.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

377_386

448.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

408_466

448.0

Topological domain

Cytoplasmic

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

118_138

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

165_185

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

187_207

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

216_236

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

258_278

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

286_306

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

324_344

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

356_376

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

387_407

467.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

118_138

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

165_185

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

187_207

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

216_236

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

258_278

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

286_306

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

324_344

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

356_376

448.0

Transmembrane

Helical

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

387_407

448.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000315050

196_258

119

637.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000315050

294_535

119

637.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000389378

196_258

119

637.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000389378

294_535

119

637.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000518977

196_258

119

636.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000518977

294_535

119

636.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000520931

196_258

584.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000520931

20_73

584.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000520931

294_535

584.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000521591

196_258

119

637.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000521591

294_535

119

637.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000522226

196_258

119

637.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000522226

294_535

119

637.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000523338

196_258

119

636.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000523338

294_535

119

636.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000315050

539_636

119

637.0

Compositional bias

Note=Pro-rich

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000389378

539_636

119

637.0

Compositional bias

Note=Pro-rich

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000518977

539_636

119

636.0

Compositional bias

Note=Pro-rich

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000520931

539_636

584.0

Compositional bias

Note=Pro-rich

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000521591

539_636

119

637.0

Compositional bias

Note=Pro-rich

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000522226

539_636

119

637.0

Compositional bias

Note=Pro-rich

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000523338

539_636

119

636.0

Compositional bias

Note=Pro-rich

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000315050

524_530

119

637.0

Motif

Nuclear localization signal

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000389378

524_530

119

637.0

Motif

Nuclear localization signal

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000518977

524_530

119

636.0

Motif

Nuclear localization signal

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000520931

524_530

584.0

Motif

Nuclear localization signal

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000521591

524_530

119

637.0

Motif

Nuclear localization signal

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000522226

524_530

119

637.0

Motif

Nuclear localization signal

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000523338

524_530

119

636.0

Motif

Nuclear localization signal

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000315050

431_588

119

637.0

Region

Required for inhibitory activity of TNF-induced NF-kappa-B activation

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000315050

452_510

119

637.0

Region

Note=Ubiquitin-binding domain (UBD)

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000389378

431_588

119

637.0

Region

Required for inhibitory activity of TNF-induced NF-kappa-B activation

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000389378

452_510

119

637.0

Region

Note=Ubiquitin-binding domain (UBD)

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000518977

431_588

119

636.0

Region

Required for inhibitory activity of TNF-induced NF-kappa-B activation

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000518977

452_510

119

636.0

Region

Note=Ubiquitin-binding domain (UBD)

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000520931

431_588

584.0

Region

Required for inhibitory activity of TNF-induced NF-kappa-B activation

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000520931

452_510

584.0

Region

Note=Ubiquitin-binding domain (UBD)

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000521591

431_588

119

637.0

Region

Required for inhibitory activity of TNF-induced NF-kappa-B activation

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000521591

452_510

119

637.0

Region

Note=Ubiquitin-binding domain (UBD)

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000522226

431_588

119

637.0

Region

Required for inhibitory activity of TNF-induced NF-kappa-B activation

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000522226

452_510

119

637.0

Region

Note=Ubiquitin-binding domain (UBD)

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000523338

431_588

119

636.0

Region

Required for inhibitory activity of TNF-induced NF-kappa-B activation

Hgene

TNIP1

chr5:150441688

chr5:156890102

ENST00000523338

452_510

119

636.0

Region

Note=Ubiquitin-binding domain (UBD)

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000311946

1_117

467.0

Topological domain

Extracellular

Tgene

NIPAL4

chr5:150441688

chr5:156890102

ENST00000435489

1_117

448.0

Topological domain

Extracellular

Top

Fusion Gene Sequence for TNIP1-NIPAL4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>92708_92708_1_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000315050_NIPAL4_chr5_156890102_ENST00000311946_length(transcript)=3402nt_BP=467nt
AGTGAGCCGAGGAGCCTTCATAGGGACAGCCGCCCCTGGTGCACACACCCTCGTATTCTCCTGCCCTTCCCCAGCCAGGCGGGCACCACG
GCAGGGGCTGAGCTACCCTCATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGGCAGCGTGCCCTCAGGAGAGGCATCCGCAG
CTTTTGAGCGCCTAGTGAAGGAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGATGTTAGGGGAGCTTTTGGAAGAGTCCCAGA
TGGAAGCGACCAGGCTCCGGCAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCG
ACCCCCTGGCTGAGCTCACAGGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCC
AGAAGCCTCCATCCAGTGTTCCCTGCTCCACCTCTACTGCTCCTCCCAAGAAGTCCTGTGCCAGATTGTCAATGACCTCAGCCCTGAGGT
GCCCAGCAATGCCACCTTTCACAGCTGGCAGGAAAGAATCAGGCAGAACTATGGCTTCTACATCGGCCTGGGCCTGGCATTCCTGTCTAG
CTTCCTCATCGGCAGCAGCGTCATCCTCAAGAAGAAAGGCCTCTTGCGACTCGTGGCCACGGGAGCCACTCGAGCTGTGGATGGAGGCTT
CGGCTACCTGAAAGATGCAATGTGGTGGGCTGGATTTCTCACCATGGCTGCTGGAGAAGTTGCCAACTTTGGAGCCTACGCATTTGCACC
TGCAACAGTCGTCACGCCTCTGGGAGCGCTGAGTGTCCTCATAAGTGCCATCCTCTCCTCATATTTCCTGAGGGAGAGTCTGAACCTGCT
GGGGAAGCTGGGCTGTGTGATCTGTGTGGCCGGAAGCACAGTGATGGTGATACATGCTCCTGAGGAAGAGAAGGTCACTACCATCATGGA
GATGGCTTCCAAGATGAAAGACACAGGGTTCATCGTGTTTGCTGTGCTTCTGCTGGTGTCATGCCTCATCCTCATCTTTGTCATTGCCCC
ACGTTACGGGCAAAGGAATATCCTCATCTACATCATCATCTGCTCTGTGATCGGGGCCTTCTCTGTGGCTGCTGTCAAGGGGCTGGGCAT
CACCATCAAGAACTTCTTCCAGGGGCTGCCAGTTGTCCGGCACCCGCTCCCCTACATCCTGTCCCTCATCCTGGCACTGTCCCTCAGCAC
TCAGGTCAACTTCCTCAACAGAGCACTGGACATTTTCAACACTTCCCTGGTGTTCCCCATCTACTACGTGTTCTTCACCACGGTGGTCGT
TACCTCGTCCATCATCCTCTTCAAGGAGTGGTACAGCATGTCTGCTGTGGACATTGCAGGCACCCTCTCGGGCTTTGTCACCATCATCTT
GGGCGTGTTCATGCTGCATGCTTTCAAAGACCTGGACATCAGCTGCGCCAGCTTGCCCCACATGCACAAAAACCCACCCCCTTCTCCCGC
CCCGGAACCCACTGTTATTAGACTGGAAGACAAGAACGTCCTTGTGGACAATATAGAACTTGCCAGCACCTCATCACCAGAAGAGAAACC
CAAAGTATTTATAATCCATTCCTGAAGCTTGGAATATGTGAGTGAGAGGATGAGTCCGATGGTACAGCCTGCCCTCCCAATTTCAAAACC
ACCTGGTTATTTTCCAGTGCAACTGTTACCAATGGGCTCTCTTTTCTTGAGAAGTTCATTTATACCTCATCACTGTTTCCAGGAGAAAAA
TCTTTACCCAAATAGCAATGGTGGCAGAACTTCCTGGAAACAGATTCAGTGACCAAATACCCAAGTTTACATCAGTGCCTGCAGGTTCCC
TGGACCTTCCTTCTCATTCATTCTTTCGGTGCCATCTCTATGCCGTTGGGAAGAAGATGGAGTCTGACCCACTGAATGTAGCACAGTCCA
AGGACTTCTCTAAGATATTGGTCATTGGAAGTTCCTTCACACCAATTCTCCTCCTGAGACGGAATCTCCGTTGTTGTTGTTGTTGTTGTT
TTCTAGCCCAAGGATGACATAGAGCTGGCTCCCAGAGGCCCACAGAGCAATTGGCCATGCCTCCCTATCCAGAGCTGACAGGGACACAAC
CAGTGTAAAATATCCTGTTGCCTTTGTCACTTCCTCTTTGGAGGCAGAAGCAAGACCTCAGCTGACCTTCTTACTGTGAAAGCCACTTGA
TGTCTCAGGGAAAAATTTCAACCAGCTCATTCCCCGAGCACTCCAGCCTGGCAGTCAGCACCTCGGCATCCACCCAGTCCATCCCACCAT
CACCCCTTCCCCCTCTACTTACATCCTAAGGAGTCGGTCACTGAGACATAAAGGCAGTAATCGCAGAACTGGAAACAAAACAATAATAGA
GCCACAGCCAAACTCTGGTGGCCAAACCCAGTGTTGCATTTTGTCTTACTCTGAAAGAAGAACAGCAAATTCACTGCTTCAAAGTGGCCT
GGCTGCCAAGCTAGAATTTGGCAGAACGCACTTTACTATTCCTCAAGGAGTCAACCAACCTATGATCTGGGGAGGTGGGAAGAGGATGAG
GAGCAAAGTTGGGATTTGGCAGAAGGCAGTCCCAGGCTCTCTGGATACTAGGGGCTAACTTTTGTGTTGACTCTGGTGCTCATCTGGGAA
CTTAGGAGAAACGAGCTCAGGGGTAATTTCTGGGTTGCAGCCTTAAAGGCTTGGACAGCTGTGAATCTCAATGGCCAACTGGAGGTGCAG
ACTTGGCATGGGGTGCATTCTAGCTGTTGACCAGATTGCTACCGAGTCCCCTCCTCCACTGATGAGCTGCCCACACTGGGAAGCAGCATG
CCCTGACTGTTCCAACACCACCTGCTATGGGGAGTACCTTTGGTCCCCTCACATTTGGCCAGAGGCATACAAAAAACCAGAGCAGCTGGA
GAGGGAGATAATTACTATTCCTTCCCTTCCTATCTCCTTTCTAGCCACAAGAGTGTGGGGGTTGGAGAAGAACCATTAGAAAGGGAAATT
AGTGGGCTGGTGTATCTGGAAAGAGGGAAGACTTGATCCTCAGCCCCGAGGTTGGTGCAGGGCCTCCCCTGTGTGACTCTACCTGCACTC
TGTGTTTATATCCTGTGCCCTAAGTGGGCCAAGCCCAGGTAAATTCCTGCTGGCCTTGGAACTCCAAGGTTTGGCTGACCAGCAGACTGG
CTCCCTGACTCTTCAGCCTCAAATCCCCAGTTTTTGATGAATGTGGATTTCTGTCTGTAATTAAAAGCAATGCAACAAGTTGGCTCTTGA

>92708_92708_1_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000315050_NIPAL4_chr5_156890102_ENST00000311946_length(amino acids)=390AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAM
WWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKD
TGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNR
ALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIR

--------------------------------------------------------------
>92708_92708_2_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000315050_NIPAL4_chr5_156890102_ENST00000435489_length(transcript)=1728nt_BP=467nt
AGTGAGCCGAGGAGCCTTCATAGGGACAGCCGCCCCTGGTGCACACACCCTCGTATTCTCCTGCCCTTCCCCAGCCAGGCGGGCACCACG
GCAGGGGCTGAGCTACCCTCATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGGCAGCGTGCCCTCAGGAGAGGCATCCGCAG
CTTTTGAGCGCCTAGTGAAGGAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGATGTTAGGGGAGCTTTTGGAAGAGTCCCAGA
TGGAAGCGACCAGGCTCCGGCAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCG
ACCCCCTGGCTGAGCTCACAGGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCC
AGAAGCCTCCATCCAGTGTTCCCTGCTCCACCTCTACTGCTCCTCCCAAGAAGTCCTGTGCCAGATTGTCAATGACCTCAGCCCTGAGGT
GCCCAGCAATGCCACCTTTCACAGCTGGCAGGAAAGAATCAGGCAGAACTATGGCTTCTACATCGGCCTGGGCCTGGCATTCCTGTCTAG
CTTCCTCATCGGCAGCAGCGTCATCCTCAAGAAGAAAGGCCTCTTGCGACTCGTGGCCACGGGAGCCACTCGAGCTGTGGCTGCTGGAGA
AGTTGCCAACTTTGGAGCCTACGCATTTGCACCTGCAACAGTCGTCACGCCTCTGGGAGCGCTGAGTGTCCTCATAAGTGCCATCCTCTC
CTCATATTTCCTGAGGGAGAGTCTGAACCTGCTGGGGAAGCTGGGCTGTGTGATCTGTGTGGCCGGAAGCACAGTGATGGTGATACATGC
TCCTGAGGAAGAGAAGGTCACTACCATCATGGAGATGGCTTCCAAGATGAAAGACACAGGGTTCATCGTGTTTGCTGTGCTTCTGCTGGT
GTCATGCCTCATCCTCATCTTTGTCATTGCCCCACGTTACGGGCAAAGGAATATCCTCATCTACATCATCATCTGCTCTGTGATCGGGGC
CTTCTCTGTGGCTGCTGTCAAGGGGCTGGGCATCACCATCAAGAACTTCTTCCAGGGGCTGCCAGTTGTCCGGCACCCGCTCCCCTACAT
CCTGTCCCTCATCCTGGCACTGTCCCTCAGCACTCAGGTCAACTTCCTCAACAGAGCACTGGACATTTTCAACACTTCCCTGGTGTTCCC
CATCTACTACGTGTTCTTCACCACGGTGGTCGTTACCTCGTCCATCATCCTCTTCAAGGAGTGGTACAGCATGTCTGCTGTGGACATTGC
AGGCACCCTCTCGGGCTTTGTCACCATCATCTTGGGCGTGTTCATGCTGCATGCTTTCAAAGACCTGGACATCAGCTGCGCCAGCTTGCC
CCACATGCACAAAAACCCACCCCCTTCTCCCGCCCCGGAACCCACTGTTATTAGACTGGAAGACAAGAACGTCCTTGTGGACAATATAGA
ACTTGCCAGCACCTCATCACCAGAAGAGAAACCCAAAGTATTTATAATCCATTCCTGAAGCTTGGAATATGTGAGTGAGAGGATGAGTCC
GATGGTACAGCCTGCCCTCCCAATTTCAAAACCACCTGGTTATTTTCCAGTGCAACTGTTACCAATGGGCTCTCTTTTCTTGAGAAGTTC

>92708_92708_2_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000315050_NIPAL4_chr5_156890102_ENST00000435489_length(amino acids)=371AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVAAGEVANFGAY
AFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF
VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFT
TVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSP

--------------------------------------------------------------
>92708_92708_3_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000389378_NIPAL4_chr5_156890102_ENST00000311946_length(transcript)=3881nt_BP=946nt
ATGCTTACGTGCCTTTTGGCAGGTCCCCTCCCTGTTCTGGCCTGTGTTCCCCTCGGCACAAGGAAGGGGCTGGGTGGTCTCTGTGGCTCG
CCTCCGCTCTGAAATTCCGGCTTTCAAGGTGGCCCCAGGCCTTCGACAGGGGCTTCCGGCGCTGGGAGTGCGGCAAGGCGCCGCGCAGGC
CCGGGACGGTGGCCCCAGGGAAGTCGCTCCTAGAGGGGAAGGCCGCCGAAGGGACGAGAGACACCGCGGGCCCCCGGAACCGCAGGCAGC
CGGTGTTTACCTCGCTCGGTCCCACCCCAGGCGGCCGCGGGCCCGCCCGGAGCGCGCGGCGCGATTGGGCGAGTGGCCTGCCAGTCTCCG
GGGACTTTCCCAGGGGTGGGGCGGCCCGGCCAGGCCCCCGGCACTTCCTCGTCCTCGGCCCGGGTGCCCTGCCCCCGTCCAGGAGCCCTA
GGAGTGCTACGGGGGGCCGGAGCCTTGCCCGGGCCGCTGCCCCGTCCCTGGATTCGGGGCTGGACGCAGCAAGCGGGGCGCTGTGTCCCC
AAGCTCCCCGTCCTCGGGCGGGCACCACGGCAGGGGCTGAGCTACCCTCATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGG
CAGCGTGCCCTCAGGAGAGGCATCCGCAGCTTTTGAGCGCCTAGTGAAGGAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGAT
GTTAGGGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCGGCAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCC
ACCACCTTCTCCCTCCTTGGGCTCCTTCGACCCCCTGGCTGAGCTCACAGGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGC
ATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGTGTTCCCTGCTCCACCTCTACTGCTCCTCCCAAGAAGTCCTGTGC
CAGATTGTCAATGACCTCAGCCCTGAGGTGCCCAGCAATGCCACCTTTCACAGCTGGCAGGAAAGAATCAGGCAGAACTATGGCTTCTAC
ATCGGCCTGGGCCTGGCATTCCTGTCTAGCTTCCTCATCGGCAGCAGCGTCATCCTCAAGAAGAAAGGCCTCTTGCGACTCGTGGCCACG
GGAGCCACTCGAGCTGTGGATGGAGGCTTCGGCTACCTGAAAGATGCAATGTGGTGGGCTGGATTTCTCACCATGGCTGCTGGAGAAGTT
GCCAACTTTGGAGCCTACGCATTTGCACCTGCAACAGTCGTCACGCCTCTGGGAGCGCTGAGTGTCCTCATAAGTGCCATCCTCTCCTCA
TATTTCCTGAGGGAGAGTCTGAACCTGCTGGGGAAGCTGGGCTGTGTGATCTGTGTGGCCGGAAGCACAGTGATGGTGATACATGCTCCT
GAGGAAGAGAAGGTCACTACCATCATGGAGATGGCTTCCAAGATGAAAGACACAGGGTTCATCGTGTTTGCTGTGCTTCTGCTGGTGTCA
TGCCTCATCCTCATCTTTGTCATTGCCCCACGTTACGGGCAAAGGAATATCCTCATCTACATCATCATCTGCTCTGTGATCGGGGCCTTC
TCTGTGGCTGCTGTCAAGGGGCTGGGCATCACCATCAAGAACTTCTTCCAGGGGCTGCCAGTTGTCCGGCACCCGCTCCCCTACATCCTG
TCCCTCATCCTGGCACTGTCCCTCAGCACTCAGGTCAACTTCCTCAACAGAGCACTGGACATTTTCAACACTTCCCTGGTGTTCCCCATC
TACTACGTGTTCTTCACCACGGTGGTCGTTACCTCGTCCATCATCCTCTTCAAGGAGTGGTACAGCATGTCTGCTGTGGACATTGCAGGC
ACCCTCTCGGGCTTTGTCACCATCATCTTGGGCGTGTTCATGCTGCATGCTTTCAAAGACCTGGACATCAGCTGCGCCAGCTTGCCCCAC
ATGCACAAAAACCCACCCCCTTCTCCCGCCCCGGAACCCACTGTTATTAGACTGGAAGACAAGAACGTCCTTGTGGACAATATAGAACTT
GCCAGCACCTCATCACCAGAAGAGAAACCCAAAGTATTTATAATCCATTCCTGAAGCTTGGAATATGTGAGTGAGAGGATGAGTCCGATG
GTACAGCCTGCCCTCCCAATTTCAAAACCACCTGGTTATTTTCCAGTGCAACTGTTACCAATGGGCTCTCTTTTCTTGAGAAGTTCATTT
ATACCTCATCACTGTTTCCAGGAGAAAAATCTTTACCCAAATAGCAATGGTGGCAGAACTTCCTGGAAACAGATTCAGTGACCAAATACC
CAAGTTTACATCAGTGCCTGCAGGTTCCCTGGACCTTCCTTCTCATTCATTCTTTCGGTGCCATCTCTATGCCGTTGGGAAGAAGATGGA
GTCTGACCCACTGAATGTAGCACAGTCCAAGGACTTCTCTAAGATATTGGTCATTGGAAGTTCCTTCACACCAATTCTCCTCCTGAGACG
GAATCTCCGTTGTTGTTGTTGTTGTTGTTTTCTAGCCCAAGGATGACATAGAGCTGGCTCCCAGAGGCCCACAGAGCAATTGGCCATGCC
TCCCTATCCAGAGCTGACAGGGACACAACCAGTGTAAAATATCCTGTTGCCTTTGTCACTTCCTCTTTGGAGGCAGAAGCAAGACCTCAG
CTGACCTTCTTACTGTGAAAGCCACTTGATGTCTCAGGGAAAAATTTCAACCAGCTCATTCCCCGAGCACTCCAGCCTGGCAGTCAGCAC
CTCGGCATCCACCCAGTCCATCCCACCATCACCCCTTCCCCCTCTACTTACATCCTAAGGAGTCGGTCACTGAGACATAAAGGCAGTAAT
CGCAGAACTGGAAACAAAACAATAATAGAGCCACAGCCAAACTCTGGTGGCCAAACCCAGTGTTGCATTTTGTCTTACTCTGAAAGAAGA
ACAGCAAATTCACTGCTTCAAAGTGGCCTGGCTGCCAAGCTAGAATTTGGCAGAACGCACTTTACTATTCCTCAAGGAGTCAACCAACCT
ATGATCTGGGGAGGTGGGAAGAGGATGAGGAGCAAAGTTGGGATTTGGCAGAAGGCAGTCCCAGGCTCTCTGGATACTAGGGGCTAACTT
TTGTGTTGACTCTGGTGCTCATCTGGGAACTTAGGAGAAACGAGCTCAGGGGTAATTTCTGGGTTGCAGCCTTAAAGGCTTGGACAGCTG
TGAATCTCAATGGCCAACTGGAGGTGCAGACTTGGCATGGGGTGCATTCTAGCTGTTGACCAGATTGCTACCGAGTCCCCTCCTCCACTG
ATGAGCTGCCCACACTGGGAAGCAGCATGCCCTGACTGTTCCAACACCACCTGCTATGGGGAGTACCTTTGGTCCCCTCACATTTGGCCA
GAGGCATACAAAAAACCAGAGCAGCTGGAGAGGGAGATAATTACTATTCCTTCCCTTCCTATCTCCTTTCTAGCCACAAGAGTGTGGGGG
TTGGAGAAGAACCATTAGAAAGGGAAATTAGTGGGCTGGTGTATCTGGAAAGAGGGAAGACTTGATCCTCAGCCCCGAGGTTGGTGCAGG
GCCTCCCCTGTGTGACTCTACCTGCACTCTGTGTTTATATCCTGTGCCCTAAGTGGGCCAAGCCCAGGTAAATTCCTGCTGGCCTTGGAA
CTCCAAGGTTTGGCTGACCAGCAGACTGGCTCCCTGACTCTTCAGCCTCAAATCCCCAGTTTTTGATGAATGTGGATTTCTGTCTGTAAT
TAAAAGCAATGCAACAAGTTGGCTCTTGAGAATGGCAGTAAACTGAGGGCCCTAAGAGTGTGGTCTGCAGGGTCAAGAATAAAGATTACA

>92708_92708_3_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000389378_NIPAL4_chr5_156890102_ENST00000311946_length(amino acids)=390AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAM
WWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKD
TGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNR
ALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIR

--------------------------------------------------------------
>92708_92708_4_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000389378_NIPAL4_chr5_156890102_ENST00000435489_length(transcript)=2207nt_BP=946nt
ATGCTTACGTGCCTTTTGGCAGGTCCCCTCCCTGTTCTGGCCTGTGTTCCCCTCGGCACAAGGAAGGGGCTGGGTGGTCTCTGTGGCTCG
CCTCCGCTCTGAAATTCCGGCTTTCAAGGTGGCCCCAGGCCTTCGACAGGGGCTTCCGGCGCTGGGAGTGCGGCAAGGCGCCGCGCAGGC
CCGGGACGGTGGCCCCAGGGAAGTCGCTCCTAGAGGGGAAGGCCGCCGAAGGGACGAGAGACACCGCGGGCCCCCGGAACCGCAGGCAGC
CGGTGTTTACCTCGCTCGGTCCCACCCCAGGCGGCCGCGGGCCCGCCCGGAGCGCGCGGCGCGATTGGGCGAGTGGCCTGCCAGTCTCCG
GGGACTTTCCCAGGGGTGGGGCGGCCCGGCCAGGCCCCCGGCACTTCCTCGTCCTCGGCCCGGGTGCCCTGCCCCCGTCCAGGAGCCCTA
GGAGTGCTACGGGGGGCCGGAGCCTTGCCCGGGCCGCTGCCCCGTCCCTGGATTCGGGGCTGGACGCAGCAAGCGGGGCGCTGTGTCCCC
AAGCTCCCCGTCCTCGGGCGGGCACCACGGCAGGGGCTGAGCTACCCTCATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGG
CAGCGTGCCCTCAGGAGAGGCATCCGCAGCTTTTGAGCGCCTAGTGAAGGAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGAT
GTTAGGGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCGGCAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCC
ACCACCTTCTCCCTCCTTGGGCTCCTTCGACCCCCTGGCTGAGCTCACAGGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGC
ATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGTGTTCCCTGCTCCACCTCTACTGCTCCTCCCAAGAAGTCCTGTGC
CAGATTGTCAATGACCTCAGCCCTGAGGTGCCCAGCAATGCCACCTTTCACAGCTGGCAGGAAAGAATCAGGCAGAACTATGGCTTCTAC
ATCGGCCTGGGCCTGGCATTCCTGTCTAGCTTCCTCATCGGCAGCAGCGTCATCCTCAAGAAGAAAGGCCTCTTGCGACTCGTGGCCACG
GGAGCCACTCGAGCTGTGGCTGCTGGAGAAGTTGCCAACTTTGGAGCCTACGCATTTGCACCTGCAACAGTCGTCACGCCTCTGGGAGCG
CTGAGTGTCCTCATAAGTGCCATCCTCTCCTCATATTTCCTGAGGGAGAGTCTGAACCTGCTGGGGAAGCTGGGCTGTGTGATCTGTGTG
GCCGGAAGCACAGTGATGGTGATACATGCTCCTGAGGAAGAGAAGGTCACTACCATCATGGAGATGGCTTCCAAGATGAAAGACACAGGG
TTCATCGTGTTTGCTGTGCTTCTGCTGGTGTCATGCCTCATCCTCATCTTTGTCATTGCCCCACGTTACGGGCAAAGGAATATCCTCATC
TACATCATCATCTGCTCTGTGATCGGGGCCTTCTCTGTGGCTGCTGTCAAGGGGCTGGGCATCACCATCAAGAACTTCTTCCAGGGGCTG
CCAGTTGTCCGGCACCCGCTCCCCTACATCCTGTCCCTCATCCTGGCACTGTCCCTCAGCACTCAGGTCAACTTCCTCAACAGAGCACTG
GACATTTTCAACACTTCCCTGGTGTTCCCCATCTACTACGTGTTCTTCACCACGGTGGTCGTTACCTCGTCCATCATCCTCTTCAAGGAG
TGGTACAGCATGTCTGCTGTGGACATTGCAGGCACCCTCTCGGGCTTTGTCACCATCATCTTGGGCGTGTTCATGCTGCATGCTTTCAAA
GACCTGGACATCAGCTGCGCCAGCTTGCCCCACATGCACAAAAACCCACCCCCTTCTCCCGCCCCGGAACCCACTGTTATTAGACTGGAA
GACAAGAACGTCCTTGTGGACAATATAGAACTTGCCAGCACCTCATCACCAGAAGAGAAACCCAAAGTATTTATAATCCATTCCTGAAGC
TTGGAATATGTGAGTGAGAGGATGAGTCCGATGGTACAGCCTGCCCTCCCAATTTCAAAACCACCTGGTTATTTTCCAGTGCAACTGTTA

>92708_92708_4_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000389378_NIPAL4_chr5_156890102_ENST00000435489_length(amino acids)=371AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVAAGEVANFGAY
AFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF
VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFT
TVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSP

--------------------------------------------------------------
>92708_92708_5_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000520931_NIPAL4_chr5_156890102_ENST00000311946_length(transcript)=3293nt_BP=358nt
CGGGTGCCCTGCCCCCGTCCAGGAGCCCTAGGAGTGCTACGGGGGGCCGGAGCCTTGCCCGGGCCGCTGCCCCGTCCCTGGATTCGGGGC
TGGACGCAGCAAGCGGGGCGCTGTGTCCCCAAGCTCCCCGTCCTCGGGGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCG
GCAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCGACCCCCTGGCTGAGCTCAC
AGGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGTGT
TCCCTGCTCCACCTCTACTGCTCCTCCCAAGAAGTCCTGTGCCAGATTGTCAATGACCTCAGCCCTGAGGTGCCCAGCAATGCCACCTTT
CACAGCTGGCAGGAAAGAATCAGGCAGAACTATGGCTTCTACATCGGCCTGGGCCTGGCATTCCTGTCTAGCTTCCTCATCGGCAGCAGC
GTCATCCTCAAGAAGAAAGGCCTCTTGCGACTCGTGGCCACGGGAGCCACTCGAGCTGTGGATGGAGGCTTCGGCTACCTGAAAGATGCA
ATGTGGTGGGCTGGATTTCTCACCATGGCTGCTGGAGAAGTTGCCAACTTTGGAGCCTACGCATTTGCACCTGCAACAGTCGTCACGCCT
CTGGGAGCGCTGAGTGTCCTCATAAGTGCCATCCTCTCCTCATATTTCCTGAGGGAGAGTCTGAACCTGCTGGGGAAGCTGGGCTGTGTG
ATCTGTGTGGCCGGAAGCACAGTGATGGTGATACATGCTCCTGAGGAAGAGAAGGTCACTACCATCATGGAGATGGCTTCCAAGATGAAA
GACACAGGGTTCATCGTGTTTGCTGTGCTTCTGCTGGTGTCATGCCTCATCCTCATCTTTGTCATTGCCCCACGTTACGGGCAAAGGAAT
ATCCTCATCTACATCATCATCTGCTCTGTGATCGGGGCCTTCTCTGTGGCTGCTGTCAAGGGGCTGGGCATCACCATCAAGAACTTCTTC
CAGGGGCTGCCAGTTGTCCGGCACCCGCTCCCCTACATCCTGTCCCTCATCCTGGCACTGTCCCTCAGCACTCAGGTCAACTTCCTCAAC
AGAGCACTGGACATTTTCAACACTTCCCTGGTGTTCCCCATCTACTACGTGTTCTTCACCACGGTGGTCGTTACCTCGTCCATCATCCTC
TTCAAGGAGTGGTACAGCATGTCTGCTGTGGACATTGCAGGCACCCTCTCGGGCTTTGTCACCATCATCTTGGGCGTGTTCATGCTGCAT
GCTTTCAAAGACCTGGACATCAGCTGCGCCAGCTTGCCCCACATGCACAAAAACCCACCCCCTTCTCCCGCCCCGGAACCCACTGTTATT
AGACTGGAAGACAAGAACGTCCTTGTGGACAATATAGAACTTGCCAGCACCTCATCACCAGAAGAGAAACCCAAAGTATTTATAATCCAT
TCCTGAAGCTTGGAATATGTGAGTGAGAGGATGAGTCCGATGGTACAGCCTGCCCTCCCAATTTCAAAACCACCTGGTTATTTTCCAGTG
CAACTGTTACCAATGGGCTCTCTTTTCTTGAGAAGTTCATTTATACCTCATCACTGTTTCCAGGAGAAAAATCTTTACCCAAATAGCAAT
GGTGGCAGAACTTCCTGGAAACAGATTCAGTGACCAAATACCCAAGTTTACATCAGTGCCTGCAGGTTCCCTGGACCTTCCTTCTCATTC
ATTCTTTCGGTGCCATCTCTATGCCGTTGGGAAGAAGATGGAGTCTGACCCACTGAATGTAGCACAGTCCAAGGACTTCTCTAAGATATT
GGTCATTGGAAGTTCCTTCACACCAATTCTCCTCCTGAGACGGAATCTCCGTTGTTGTTGTTGTTGTTGTTTTCTAGCCCAAGGATGACA
TAGAGCTGGCTCCCAGAGGCCCACAGAGCAATTGGCCATGCCTCCCTATCCAGAGCTGACAGGGACACAACCAGTGTAAAATATCCTGTT
GCCTTTGTCACTTCCTCTTTGGAGGCAGAAGCAAGACCTCAGCTGACCTTCTTACTGTGAAAGCCACTTGATGTCTCAGGGAAAAATTTC
AACCAGCTCATTCCCCGAGCACTCCAGCCTGGCAGTCAGCACCTCGGCATCCACCCAGTCCATCCCACCATCACCCCTTCCCCCTCTACT
TACATCCTAAGGAGTCGGTCACTGAGACATAAAGGCAGTAATCGCAGAACTGGAAACAAAACAATAATAGAGCCACAGCCAAACTCTGGT
GGCCAAACCCAGTGTTGCATTTTGTCTTACTCTGAAAGAAGAACAGCAAATTCACTGCTTCAAAGTGGCCTGGCTGCCAAGCTAGAATTT
GGCAGAACGCACTTTACTATTCCTCAAGGAGTCAACCAACCTATGATCTGGGGAGGTGGGAAGAGGATGAGGAGCAAAGTTGGGATTTGG
CAGAAGGCAGTCCCAGGCTCTCTGGATACTAGGGGCTAACTTTTGTGTTGACTCTGGTGCTCATCTGGGAACTTAGGAGAAACGAGCTCA
GGGGTAATTTCTGGGTTGCAGCCTTAAAGGCTTGGACAGCTGTGAATCTCAATGGCCAACTGGAGGTGCAGACTTGGCATGGGGTGCATT
CTAGCTGTTGACCAGATTGCTACCGAGTCCCCTCCTCCACTGATGAGCTGCCCACACTGGGAAGCAGCATGCCCTGACTGTTCCAACACC
ACCTGCTATGGGGAGTACCTTTGGTCCCCTCACATTTGGCCAGAGGCATACAAAAAACCAGAGCAGCTGGAGAGGGAGATAATTACTATT
CCTTCCCTTCCTATCTCCTTTCTAGCCACAAGAGTGTGGGGGTTGGAGAAGAACCATTAGAAAGGGAAATTAGTGGGCTGGTGTATCTGG
AAAGAGGGAAGACTTGATCCTCAGCCCCGAGGTTGGTGCAGGGCCTCCCCTGTGTGACTCTACCTGCACTCTGTGTTTATATCCTGTGCC
CTAAGTGGGCCAAGCCCAGGTAAATTCCTGCTGGCCTTGGAACTCCAAGGTTTGGCTGACCAGCAGACTGGCTCCCTGACTCTTCAGCCT
CAAATCCCCAGTTTTTGATGAATGTGGATTTCTGTCTGTAATTAAAAGCAATGCAACAAGTTGGCTCTTGAGAATGGCAGTAAACTGAGG

>92708_92708_5_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000520931_NIPAL4_chr5_156890102_ENST00000311946_length(amino acids)=390AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAM
WWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKD
TGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNR
ALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIR

--------------------------------------------------------------
>92708_92708_6_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000520931_NIPAL4_chr5_156890102_ENST00000435489_length(transcript)=1619nt_BP=358nt
CGGGTGCCCTGCCCCCGTCCAGGAGCCCTAGGAGTGCTACGGGGGGCCGGAGCCTTGCCCGGGCCGCTGCCCCGTCCCTGGATTCGGGGC
TGGACGCAGCAAGCGGGGCGCTGTGTCCCCAAGCTCCCCGTCCTCGGGGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCG
GCAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCGACCCCCTGGCTGAGCTCAC
AGGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGTGT
TCCCTGCTCCACCTCTACTGCTCCTCCCAAGAAGTCCTGTGCCAGATTGTCAATGACCTCAGCCCTGAGGTGCCCAGCAATGCCACCTTT
CACAGCTGGCAGGAAAGAATCAGGCAGAACTATGGCTTCTACATCGGCCTGGGCCTGGCATTCCTGTCTAGCTTCCTCATCGGCAGCAGC
GTCATCCTCAAGAAGAAAGGCCTCTTGCGACTCGTGGCCACGGGAGCCACTCGAGCTGTGGCTGCTGGAGAAGTTGCCAACTTTGGAGCC
TACGCATTTGCACCTGCAACAGTCGTCACGCCTCTGGGAGCGCTGAGTGTCCTCATAAGTGCCATCCTCTCCTCATATTTCCTGAGGGAG
AGTCTGAACCTGCTGGGGAAGCTGGGCTGTGTGATCTGTGTGGCCGGAAGCACAGTGATGGTGATACATGCTCCTGAGGAAGAGAAGGTC
ACTACCATCATGGAGATGGCTTCCAAGATGAAAGACACAGGGTTCATCGTGTTTGCTGTGCTTCTGCTGGTGTCATGCCTCATCCTCATC
TTTGTCATTGCCCCACGTTACGGGCAAAGGAATATCCTCATCTACATCATCATCTGCTCTGTGATCGGGGCCTTCTCTGTGGCTGCTGTC
AAGGGGCTGGGCATCACCATCAAGAACTTCTTCCAGGGGCTGCCAGTTGTCCGGCACCCGCTCCCCTACATCCTGTCCCTCATCCTGGCA
CTGTCCCTCAGCACTCAGGTCAACTTCCTCAACAGAGCACTGGACATTTTCAACACTTCCCTGGTGTTCCCCATCTACTACGTGTTCTTC
ACCACGGTGGTCGTTACCTCGTCCATCATCCTCTTCAAGGAGTGGTACAGCATGTCTGCTGTGGACATTGCAGGCACCCTCTCGGGCTTT
GTCACCATCATCTTGGGCGTGTTCATGCTGCATGCTTTCAAAGACCTGGACATCAGCTGCGCCAGCTTGCCCCACATGCACAAAAACCCA
CCCCCTTCTCCCGCCCCGGAACCCACTGTTATTAGACTGGAAGACAAGAACGTCCTTGTGGACAATATAGAACTTGCCAGCACCTCATCA
CCAGAAGAGAAACCCAAAGTATTTATAATCCATTCCTGAAGCTTGGAATATGTGAGTGAGAGGATGAGTCCGATGGTACAGCCTGCCCTC

>92708_92708_6_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000520931_NIPAL4_chr5_156890102_ENST00000435489_length(amino acids)=371AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVAAGEVANFGAY
AFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF
VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFT
TVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSP

--------------------------------------------------------------
>92708_92708_7_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000523338_NIPAL4_chr5_156890102_ENST00000311946_length(transcript)=3402nt_BP=467nt
AGTGAGCCGAGGAGCCTTCATAGGGACAGCCGCCCCTGGTGCACACACCCTCGTATTCTCCTGCCCTTCCCCAGCCAGGCGGGCACCACG
GCAGGGGCTGAGCTACCCTCATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGGCAGCGTGCCCTCAGGAGAGGCATCCGCAG
CTTTTGAGCGCCTAGTGAAGGAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGATGTTAGGGGAGCTTTTGGAAGAGTCCCAGA
TGGAAGCGACCAGGCTCCGGCAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCG
ACCCCCTGGCTGAGCTCACAGGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCC
AGAAGCCTCCATCCAGTGTTCCCTGCTCCACCTCTACTGCTCCTCCCAAGAAGTCCTGTGCCAGATTGTCAATGACCTCAGCCCTGAGGT
GCCCAGCAATGCCACCTTTCACAGCTGGCAGGAAAGAATCAGGCAGAACTATGGCTTCTACATCGGCCTGGGCCTGGCATTCCTGTCTAG
CTTCCTCATCGGCAGCAGCGTCATCCTCAAGAAGAAAGGCCTCTTGCGACTCGTGGCCACGGGAGCCACTCGAGCTGTGGATGGAGGCTT
CGGCTACCTGAAAGATGCAATGTGGTGGGCTGGATTTCTCACCATGGCTGCTGGAGAAGTTGCCAACTTTGGAGCCTACGCATTTGCACC
TGCAACAGTCGTCACGCCTCTGGGAGCGCTGAGTGTCCTCATAAGTGCCATCCTCTCCTCATATTTCCTGAGGGAGAGTCTGAACCTGCT
GGGGAAGCTGGGCTGTGTGATCTGTGTGGCCGGAAGCACAGTGATGGTGATACATGCTCCTGAGGAAGAGAAGGTCACTACCATCATGGA
GATGGCTTCCAAGATGAAAGACACAGGGTTCATCGTGTTTGCTGTGCTTCTGCTGGTGTCATGCCTCATCCTCATCTTTGTCATTGCCCC
ACGTTACGGGCAAAGGAATATCCTCATCTACATCATCATCTGCTCTGTGATCGGGGCCTTCTCTGTGGCTGCTGTCAAGGGGCTGGGCAT
CACCATCAAGAACTTCTTCCAGGGGCTGCCAGTTGTCCGGCACCCGCTCCCCTACATCCTGTCCCTCATCCTGGCACTGTCCCTCAGCAC
TCAGGTCAACTTCCTCAACAGAGCACTGGACATTTTCAACACTTCCCTGGTGTTCCCCATCTACTACGTGTTCTTCACCACGGTGGTCGT
TACCTCGTCCATCATCCTCTTCAAGGAGTGGTACAGCATGTCTGCTGTGGACATTGCAGGCACCCTCTCGGGCTTTGTCACCATCATCTT
GGGCGTGTTCATGCTGCATGCTTTCAAAGACCTGGACATCAGCTGCGCCAGCTTGCCCCACATGCACAAAAACCCACCCCCTTCTCCCGC
CCCGGAACCCACTGTTATTAGACTGGAAGACAAGAACGTCCTTGTGGACAATATAGAACTTGCCAGCACCTCATCACCAGAAGAGAAACC
CAAAGTATTTATAATCCATTCCTGAAGCTTGGAATATGTGAGTGAGAGGATGAGTCCGATGGTACAGCCTGCCCTCCCAATTTCAAAACC
ACCTGGTTATTTTCCAGTGCAACTGTTACCAATGGGCTCTCTTTTCTTGAGAAGTTCATTTATACCTCATCACTGTTTCCAGGAGAAAAA
TCTTTACCCAAATAGCAATGGTGGCAGAACTTCCTGGAAACAGATTCAGTGACCAAATACCCAAGTTTACATCAGTGCCTGCAGGTTCCC
TGGACCTTCCTTCTCATTCATTCTTTCGGTGCCATCTCTATGCCGTTGGGAAGAAGATGGAGTCTGACCCACTGAATGTAGCACAGTCCA
AGGACTTCTCTAAGATATTGGTCATTGGAAGTTCCTTCACACCAATTCTCCTCCTGAGACGGAATCTCCGTTGTTGTTGTTGTTGTTGTT
TTCTAGCCCAAGGATGACATAGAGCTGGCTCCCAGAGGCCCACAGAGCAATTGGCCATGCCTCCCTATCCAGAGCTGACAGGGACACAAC
CAGTGTAAAATATCCTGTTGCCTTTGTCACTTCCTCTTTGGAGGCAGAAGCAAGACCTCAGCTGACCTTCTTACTGTGAAAGCCACTTGA
TGTCTCAGGGAAAAATTTCAACCAGCTCATTCCCCGAGCACTCCAGCCTGGCAGTCAGCACCTCGGCATCCACCCAGTCCATCCCACCAT
CACCCCTTCCCCCTCTACTTACATCCTAAGGAGTCGGTCACTGAGACATAAAGGCAGTAATCGCAGAACTGGAAACAAAACAATAATAGA
GCCACAGCCAAACTCTGGTGGCCAAACCCAGTGTTGCATTTTGTCTTACTCTGAAAGAAGAACAGCAAATTCACTGCTTCAAAGTGGCCT
GGCTGCCAAGCTAGAATTTGGCAGAACGCACTTTACTATTCCTCAAGGAGTCAACCAACCTATGATCTGGGGAGGTGGGAAGAGGATGAG
GAGCAAAGTTGGGATTTGGCAGAAGGCAGTCCCAGGCTCTCTGGATACTAGGGGCTAACTTTTGTGTTGACTCTGGTGCTCATCTGGGAA
CTTAGGAGAAACGAGCTCAGGGGTAATTTCTGGGTTGCAGCCTTAAAGGCTTGGACAGCTGTGAATCTCAATGGCCAACTGGAGGTGCAG
ACTTGGCATGGGGTGCATTCTAGCTGTTGACCAGATTGCTACCGAGTCCCCTCCTCCACTGATGAGCTGCCCACACTGGGAAGCAGCATG
CCCTGACTGTTCCAACACCACCTGCTATGGGGAGTACCTTTGGTCCCCTCACATTTGGCCAGAGGCATACAAAAAACCAGAGCAGCTGGA
GAGGGAGATAATTACTATTCCTTCCCTTCCTATCTCCTTTCTAGCCACAAGAGTGTGGGGGTTGGAGAAGAACCATTAGAAAGGGAAATT
AGTGGGCTGGTGTATCTGGAAAGAGGGAAGACTTGATCCTCAGCCCCGAGGTTGGTGCAGGGCCTCCCCTGTGTGACTCTACCTGCACTC
TGTGTTTATATCCTGTGCCCTAAGTGGGCCAAGCCCAGGTAAATTCCTGCTGGCCTTGGAACTCCAAGGTTTGGCTGACCAGCAGACTGG
CTCCCTGACTCTTCAGCCTCAAATCCCCAGTTTTTGATGAATGTGGATTTCTGTCTGTAATTAAAAGCAATGCAACAAGTTGGCTCTTGA

>92708_92708_7_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000523338_NIPAL4_chr5_156890102_ENST00000311946_length(amino acids)=390AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAM
WWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKD
TGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNR
ALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIR

--------------------------------------------------------------
>92708_92708_8_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000523338_NIPAL4_chr5_156890102_ENST00000435489_length(transcript)=1728nt_BP=467nt
AGTGAGCCGAGGAGCCTTCATAGGGACAGCCGCCCCTGGTGCACACACCCTCGTATTCTCCTGCCCTTCCCCAGCCAGGCGGGCACCACG
GCAGGGGCTGAGCTACCCTCATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGGCAGCGTGCCCTCAGGAGAGGCATCCGCAG
CTTTTGAGCGCCTAGTGAAGGAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGATGTTAGGGGAGCTTTTGGAAGAGTCCCAGA
TGGAAGCGACCAGGCTCCGGCAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCG
ACCCCCTGGCTGAGCTCACAGGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCC
AGAAGCCTCCATCCAGTGTTCCCTGCTCCACCTCTACTGCTCCTCCCAAGAAGTCCTGTGCCAGATTGTCAATGACCTCAGCCCTGAGGT
GCCCAGCAATGCCACCTTTCACAGCTGGCAGGAAAGAATCAGGCAGAACTATGGCTTCTACATCGGCCTGGGCCTGGCATTCCTGTCTAG
CTTCCTCATCGGCAGCAGCGTCATCCTCAAGAAGAAAGGCCTCTTGCGACTCGTGGCCACGGGAGCCACTCGAGCTGTGGCTGCTGGAGA
AGTTGCCAACTTTGGAGCCTACGCATTTGCACCTGCAACAGTCGTCACGCCTCTGGGAGCGCTGAGTGTCCTCATAAGTGCCATCCTCTC
CTCATATTTCCTGAGGGAGAGTCTGAACCTGCTGGGGAAGCTGGGCTGTGTGATCTGTGTGGCCGGAAGCACAGTGATGGTGATACATGC
TCCTGAGGAAGAGAAGGTCACTACCATCATGGAGATGGCTTCCAAGATGAAAGACACAGGGTTCATCGTGTTTGCTGTGCTTCTGCTGGT
GTCATGCCTCATCCTCATCTTTGTCATTGCCCCACGTTACGGGCAAAGGAATATCCTCATCTACATCATCATCTGCTCTGTGATCGGGGC
CTTCTCTGTGGCTGCTGTCAAGGGGCTGGGCATCACCATCAAGAACTTCTTCCAGGGGCTGCCAGTTGTCCGGCACCCGCTCCCCTACAT
CCTGTCCCTCATCCTGGCACTGTCCCTCAGCACTCAGGTCAACTTCCTCAACAGAGCACTGGACATTTTCAACACTTCCCTGGTGTTCCC
CATCTACTACGTGTTCTTCACCACGGTGGTCGTTACCTCGTCCATCATCCTCTTCAAGGAGTGGTACAGCATGTCTGCTGTGGACATTGC
AGGCACCCTCTCGGGCTTTGTCACCATCATCTTGGGCGTGTTCATGCTGCATGCTTTCAAAGACCTGGACATCAGCTGCGCCAGCTTGCC
CCACATGCACAAAAACCCACCCCCTTCTCCCGCCCCGGAACCCACTGTTATTAGACTGGAAGACAAGAACGTCCTTGTGGACAATATAGA
ACTTGCCAGCACCTCATCACCAGAAGAGAAACCCAAAGTATTTATAATCCATTCCTGAAGCTTGGAATATGTGAGTGAGAGGATGAGTCC
GATGGTACAGCCTGCCCTCCCAATTTCAAAACCACCTGGTTATTTTCCAGTGCAACTGTTACCAATGGGCTCTCTTTTCTTGAGAAGTTC

>92708_92708_8_TNIP1-NIPAL4_TNIP1_chr5_150441688_ENST00000523338_NIPAL4_chr5_156890102_ENST00000435489_length(amino acids)=371AA_BP=1
MLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVAAGEVANFGAY
AFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIF
VIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFT
TVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TNIP1-NIPAL4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	TNIP1	chr5:150441688	chr5:156890102	ENST00000315050	-	4	18	94_412	119.0	637.0	Nef
Hgene	TNIP1	chr5:150441688	chr5:156890102	ENST00000389378	-	4	18	94_412	119.0	637.0	Nef
Hgene	TNIP1	chr5:150441688	chr5:156890102	ENST00000518977	-	4	18	94_412	119.0	636.0	Nef
Hgene	TNIP1	chr5:150441688	chr5:156890102	ENST00000520931	-	3	17	94_412	66.0	584.0	Nef
Hgene	TNIP1	chr5:150441688	chr5:156890102	ENST00000521591	-	4	18	94_412	119.0	637.0	Nef
Hgene	TNIP1	chr5:150441688	chr5:156890102	ENST00000522226	-	4	18	94_412	119.0	637.0	Nef
Hgene	TNIP1	chr5:150441688	chr5:156890102	ENST00000523338	-	4	18	94_412	119.0	636.0	Nef
Hgene	TNIP1	chr5:150441688	chr5:156890102	ENST00000315050	-	4	18	351_367	119.0	637.0	Shigella flexneri ipah9.8
Hgene	TNIP1	chr5:150441688	chr5:156890102	ENST00000389378	-	4	18	351_367	119.0	637.0	Shigella flexneri ipah9.8
Hgene	TNIP1	chr5:150441688	chr5:156890102	ENST00000518977	-	4	18	351_367	119.0	636.0	Shigella flexneri ipah9.8
Hgene	TNIP1	chr5:150441688	chr5:156890102	ENST00000520931	-	3	17	351_367	66.0	584.0	Shigella flexneri ipah9.8
Hgene	TNIP1	chr5:150441688	chr5:156890102	ENST00000521591	-	4	18	351_367	119.0	637.0	Shigella flexneri ipah9.8
Hgene	TNIP1	chr5:150441688	chr5:156890102	ENST00000522226	-	4	18	351_367	119.0	637.0	Shigella flexneri ipah9.8
Hgene	TNIP1	chr5:150441688	chr5:156890102	ENST00000523338	-	4	18	351_367	119.0	636.0	Shigella flexneri ipah9.8

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TNIP1-NIPAL4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TNIP1-NIPAL4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source