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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TNIP1-ZWILCH (FusionGDB2 ID:92714)

Fusion Gene Summary for TNIP1-ZWILCH

check button Fusion gene summary
Fusion gene informationFusion gene name: TNIP1-ZWILCH
Fusion gene ID: 92714
HgeneTgene
Gene symbol

TNIP1

ZWILCH

Gene ID

10318

55055

Gene nameTNFAIP3 interacting protein 1zwilch kinetochore protein
SynonymsABIN-1|NAF1|VAN|nip40-1KNTC1AP|hZwilch
Cytomap

5q33.1

15q22.31

Type of geneprotein-codingprotein-coding
DescriptionTNFAIP3-interacting protein 1A20-binding inhibitor of NF-kappa-B activation 1HIV-1 Nef-interacting proteinNef-associated factor 1 SNPvirion-associated nuclear shuttling proteinprotein zwilch homologZwilch, kinetochore associated, homologhomolog of Drosophila Zwilch
Modification date2020032720200313
UniProtAcc

Q15025

.
Ensembl transtripts involved in fusion geneENST00000315050, ENST00000389378, 
ENST00000518977, ENST00000520931, 
ENST00000521591, ENST00000522226, 
ENST00000523200, ENST00000523338, 
ENST00000521423, ENST00000524280, 
ENST00000565960, ENST00000307897, 
ENST00000446801, ENST00000535141, 
ENST00000565627, 
Fusion gene scores* DoF score11 X 10 X 7=7702 X 2 X 2=8
# samples 112
** MAII scorelog2(11/770*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: TNIP1 [Title/Abstract] AND ZWILCH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTNIP1(150411847)-ZWILCH(66820194), # samples:1
Anticipated loss of major functional domain due to fusion event.TNIP1-ZWILCH seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TNIP1-ZWILCH seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNIP1

GO:0009101

glycoprotein biosynthetic process

9923610

HgeneTNIP1

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

16684768

HgeneTNIP1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

12220502

HgeneTNIP1

GO:0085032

modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade

20010814

HgeneTNIP1

GO:1903003

positive regulation of protein deubiquitination

16684768


check buttonFusion gene breakpoints across TNIP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZWILCH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer5263NTNIP1chr5

150411847

-ZWILCHchr15

66820194

+


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Fusion Gene ORF analysis for TNIP1-ZWILCH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000315050ENST00000565960TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
5CDS-intronENST00000389378ENST00000565960TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
5CDS-intronENST00000518977ENST00000565960TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
5CDS-intronENST00000520931ENST00000565960TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
5CDS-intronENST00000521591ENST00000565960TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
5CDS-intronENST00000522226ENST00000565960TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
5CDS-intronENST00000523200ENST00000565960TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
5CDS-intronENST00000523338ENST00000565960TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000315050ENST00000307897TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000315050ENST00000446801TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000315050ENST00000535141TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000315050ENST00000565627TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000389378ENST00000307897TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000389378ENST00000446801TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000389378ENST00000535141TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000389378ENST00000565627TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000518977ENST00000307897TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000518977ENST00000446801TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000518977ENST00000535141TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000518977ENST00000565627TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000520931ENST00000307897TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000520931ENST00000446801TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000520931ENST00000535141TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000520931ENST00000565627TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000521591ENST00000307897TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000521591ENST00000446801TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000521591ENST00000535141TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000521591ENST00000565627TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000522226ENST00000307897TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000522226ENST00000446801TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000522226ENST00000535141TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000522226ENST00000565627TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000523338ENST00000307897TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000523338ENST00000446801TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000523338ENST00000535141TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
Frame-shiftENST00000523338ENST00000565627TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
In-frameENST00000523200ENST00000307897TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
In-frameENST00000523200ENST00000446801TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
In-frameENST00000523200ENST00000535141TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
In-frameENST00000523200ENST00000565627TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
intron-3CDSENST00000521423ENST00000307897TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
intron-3CDSENST00000521423ENST00000446801TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
intron-3CDSENST00000521423ENST00000535141TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
intron-3CDSENST00000521423ENST00000565627TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
intron-3CDSENST00000524280ENST00000307897TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
intron-3CDSENST00000524280ENST00000446801TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
intron-3CDSENST00000524280ENST00000535141TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
intron-3CDSENST00000524280ENST00000565627TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
intron-intronENST00000521423ENST00000565960TNIP1chr5

150411847

-ZWILCHchr15

66820194

+
intron-intronENST00000524280ENST00000565960TNIP1chr5

150411847

-ZWILCHchr15

66820194

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000523200TNIP1chr5150411847-ENST00000535141ZWILCHchr1566820194+2649168402546848
ENST00000523200TNIP1chr5150411847-ENST00000307897ZWILCHchr1566820194+4000168402546848
ENST00000523200TNIP1chr5150411847-ENST00000446801ZWILCHchr1566820194+3710168402546848
ENST00000523200TNIP1chr5150411847-ENST00000565627ZWILCHchr1566820194+2573168402546848

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000523200ENST00000535141TNIP1chr5150411847-ZWILCHchr1566820194+0.0188492160.9811508
ENST00000523200ENST00000307897TNIP1chr5150411847-ZWILCHchr1566820194+0.0018414550.9981585
ENST00000523200ENST00000446801TNIP1chr5150411847-ZWILCHchr1566820194+0.0023731590.99762684
ENST00000523200ENST00000565627TNIP1chr5150411847-ZWILCHchr1566820194+0.0212411790.9787588

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Fusion Genomic Features for TNIP1-ZWILCH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TNIP1chr5150411847-ZWILCHchr1566820194+0.0132410140.986759
TNIP1chr5150411847-ZWILCHchr1566820194+0.0132410140.986759

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TNIP1-ZWILCH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:150411847/chr15:66820194)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TNIP1

Q15025

.
FUNCTION: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269|PubMed:12220502, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17016622, ECO:0000269|PubMed:17632516, ECO:0000269|PubMed:20010814}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNIP1chr5:150411847chr15:66820194ENST00000315050-1718196_258625637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000315050-171820_73625637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000315050-1718294_535625637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000389378-1718196_258625637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000389378-171820_73625637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000389378-1718294_535625637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000518977-1718196_258625636.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000518977-171820_73625636.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000518977-1718294_535625636.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000520931-1617196_258572584.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000520931-161720_73572584.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000520931-1617294_535572584.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000521591-1718196_258625637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000521591-171820_73625637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000521591-1718294_535625637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000522226-1718196_258625637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000522226-171820_73625637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000522226-1718294_535625637.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000523338-1718196_258625636.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000523338-171820_73625636.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000523338-1718294_535625636.0Coiled coilOntology_term=ECO:0000255
HgeneTNIP1chr5:150411847chr15:66820194ENST00000315050-1718524_530625637.0MotifNuclear localization signal
HgeneTNIP1chr5:150411847chr15:66820194ENST00000389378-1718524_530625637.0MotifNuclear localization signal
HgeneTNIP1chr5:150411847chr15:66820194ENST00000518977-1718524_530625636.0MotifNuclear localization signal
HgeneTNIP1chr5:150411847chr15:66820194ENST00000520931-1617524_530572584.0MotifNuclear localization signal
HgeneTNIP1chr5:150411847chr15:66820194ENST00000521591-1718524_530625637.0MotifNuclear localization signal
HgeneTNIP1chr5:150411847chr15:66820194ENST00000522226-1718524_530625637.0MotifNuclear localization signal
HgeneTNIP1chr5:150411847chr15:66820194ENST00000523338-1718524_530625636.0MotifNuclear localization signal
HgeneTNIP1chr5:150411847chr15:66820194ENST00000315050-1718431_588625637.0RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150411847chr15:66820194ENST00000315050-1718452_510625637.0RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150411847chr15:66820194ENST00000389378-1718431_588625637.0RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150411847chr15:66820194ENST00000389378-1718452_510625637.0RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150411847chr15:66820194ENST00000518977-1718431_588625636.0RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150411847chr15:66820194ENST00000518977-1718452_510625636.0RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150411847chr15:66820194ENST00000520931-1617452_510572584.0RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150411847chr15:66820194ENST00000521591-1718431_588625637.0RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150411847chr15:66820194ENST00000521591-1718452_510625637.0RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150411847chr15:66820194ENST00000522226-1718431_588625637.0RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150411847chr15:66820194ENST00000522226-1718452_510625637.0RegionNote=Ubiquitin-binding domain (UBD)
HgeneTNIP1chr5:150411847chr15:66820194ENST00000523338-1718431_588625636.0RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation
HgeneTNIP1chr5:150411847chr15:66820194ENST00000523338-1718452_510625636.0RegionNote=Ubiquitin-binding domain (UBD)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNIP1chr5:150411847chr15:66820194ENST00000315050-1718539_636625637.0Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150411847chr15:66820194ENST00000389378-1718539_636625637.0Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150411847chr15:66820194ENST00000518977-1718539_636625636.0Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150411847chr15:66820194ENST00000520931-1617539_636572584.0Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150411847chr15:66820194ENST00000521591-1718539_636625637.0Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150411847chr15:66820194ENST00000522226-1718539_636625637.0Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150411847chr15:66820194ENST00000523338-1718539_636625636.0Compositional biasNote=Pro-rich
HgeneTNIP1chr5:150411847chr15:66820194ENST00000520931-1617431_588572584.0RegionRequired for inhibitory activity of TNF-induced NF-kappa-B activation


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Fusion Gene Sequence for TNIP1-ZWILCH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92714_92714_1_TNIP1-ZWILCH_TNIP1_chr5_150411847_ENST00000523200_ZWILCH_chr15_66820194_ENST00000307897_length(transcript)=4000nt_BP=1684nt
ATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGGCAGCGTGCCCTCAGGAGAGGCATCCGCAGCTTTTGAGCGCCTAGTGAAG
GAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGATGTTAGGGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCGG
CAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCGACCCCCTGGCTGAGCTCACA
GGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGTGGC
ACCTCCTCTGAATTTGAAGTGGTCACTCCTGAGGAGCAGAATTCACCAGAGAGCAGCAGCCATGCCAATGCGATGGCGCTGGGCCCCCTG
CCCCGTGAGGACGGCAACCTGATGCTGCACCTGCAGCGCCTGGAGACCACGCTGAGTGTGTGTGCCGAGGAGCCGGACCACGGCCAGCTC
TTCACCCACCTGGGCCGCATGGCCCTGGAGTTCAACCGACTGGCATCCAAGGTGCACAAGAATGAGCAGCGCACCTCCATTCTGCAGACC
CTGTGTGAGCAGCTTCGGAAGGAGAACGAGGCTCTGAAGGCCAAGTTGGATAAGGGCCTGGAACAGCGGGATCAGGCTGCCGAGAGGCTG
CGGGAGGAAAATTTGGAGCTCAAGAAGTTGTTGATGAGCAATGGCAACAAAGAGGGTGCGTCTGGGCGGCCAGGCTCACCGAAGATGGAA
GGGACAGGCAAGAAGGCAGTGGCTGGACAGCAGCAGGCTAGTGTGACGGCAGGTAAGGTCCCAGAGGTGGTGGCCTTGGGCGCAGCCGAG
AAGAAGGTGAAGATGCTGGAGCAGCAGCGCAGTGAGCTGCTGGAAGTGAACAAGCAGTGGGACCAGCATTTCCGGTCCATGAAGCAGCAG
TATGAGCAGAAGATCACTGAGCTGCGTCAGAAGCTGGCTGATTTGCAGAAGCAGGTGACTGACCTGGAGGCCGAGCGGGAGCAGAAGCAG
CGTGACTTTGACCGCAAGCTCCTCCTGGCCAAGTCCAAGATTGAAATGGAGGAGACCGACAAGGAGCAGCTGACAGCAGAGGCCAAGGAG
CTGCGCCAAAAGGTCAAGTACCTGCAGGATCAGCTGAGCCCACTCACCCGACAGCGTGAGTACCAGGAAAAGGAGATCCAGCGGCTCAAC
AAGGCCCTGGAGGAAGCACTGAGCATCCAAACCCCGCCATCATCTCCACCAACAGCATTTGGGAGCCCAGAAGGAGCAGGGGCCCTCCTA
AGGAAACAGGAGCTGGTCACGCAGAATGAGTTGCTGAAACAGCAGGTGAAGATCTTCGAGGAGGACTTCCAGAGGGAGCGCAGTGATCGT
GAGCGCATGAATGAGGAGAAGGAAGAGCTGAAGAAGCAAGTGGAGAAGCTGCAGGCCCAGGTCACCCTGTCAAATGCCCAGCTAAAAGCA
TTCAAAGATGAGGAGAAGGCAAGAGAAGCCCTCAGACAGCAGAAGAGGAAAGCAAAGCCGGAATACACCTGGCGTCTACCCTGTGGAGGG
GTTCGAAATCCAAATCAGAGCTCCCAAGTGATGGACCCTCCCACAGCCAGGCCTACAGAACCAGACTTAAATAAGCTGGATGGATTTGGT
GATTCTACAAAAAAAGACACTGAGGTTGAGACCTTGAAGCATGACACTGCTGCAGTCGATCGTTCCGTCAAGCGTCTTTTCAAAGTTCGG
AGTGATCTTGATTTTGCTGAGCAACTGTGGTGCAAAATGAGCAGTAGTGTGATTTCATACCAAGACTTGGTGAAGTGTTTCACATTGATC
ATCCAGAGTCTACAACGTGGTGATATACAGCCATGGCTCCATAGTGGAAGTAACAGTTTACTAAGTAAGCTCATTCATCAGTCTTATCAT
GGAACCATGGACACAGTTTCTCTCAGTGGGACTATTCCAGTTCAAATGCTTTTGGAAATTGGTTTGGACAAACTAAAGAAAGATTATATC
AGTTTTTTCATAGGTCAGGAACTTGCATCTTTGAATCATTTGGAATACTTCATTGCTCCATCAGTAGATATACAAGAACAGGTTTATCGT
GTCCAAAAACTCCACCATATTCTAGAAATATTAGTCAGTTGCATGCCTTTCATTAAATCTCAACATGAACTCCTCTTTTCTTTAACACAG
ATCTGCATAAAGTATTACAAACAAAATCCTCTTGATGAGCAACACATTTTTCAGCTGCCAGTCAGACCAACTGCTGTAAAGAACTTATAT
CAAAGTGAGAAGCCACAGAAATGGAGAGTGGAAATATATAGTGGTCAAAAGAAGATTAAGACAGTTTGGCAACTGAGTGACAGCTCACCC
ATAGACCATCTGAATTTTCACAAACCTGATTTTTCGGAATTAACACTAAACGGTAGCCTGGAAGAAAGGATATTCTTTACTAACATGGTT
ACCTGCAGCCAGGTGCATTTCAAGTGAAGTGTGCTGATGAAGTCCTCTATAAGCACAAGCCAAAAAGAGAAAGAGAAAAAAAGGTAATTA
TTGTAGAACCTGAAAACAGCAATGTATGGAAACCCTCAAAGCAGAAAAGGGAGGAAGATCCTGAAGATTCTCTTATGAAGCTCCAAAATT
GATAATCCTGTCTCAGCTCTGCCTCCTCAGGAGGAGCATTAGTAGAACAGCAGTGATGAGGACACAGAGGGAGCAGACAGTGGGTACCAC
GATCTCCGTAACCATTTGCATGTGACTTAGCAAGGGCTCTGAAATGACAAAGAGAACGAGCACCACAAATGAGAACAGGATCATTTTAGT
AAATACAGCTTTATCCCAAAAGCTTTAACTGTATTGGGAAAACTTAAAAAATAGCATCCTCAAATTTTCTGATTCTTATTTGCCATGAAA
TAGAACTTAGTAAATTAAATGTTATTTGAAAATGTTATAAGAGCTTTGTAAATATTTCAGAAAATATGGGATAAATGCCTGAATTTGGTT
CTTCTACAGGTGCTATAATAAAGTCCATCTCTCAATACTTATACTTTCTAAATTCATCTCAGAATATTAGCAGCCATATTCCACAGTTCC
TATAATTTTTACTGGGGGGGATTTGTGATAGGAAAGTCCTTGGGAAACATTTCCAATCTTTCAAAATATTATTGTGTATCTTAAGAAGTA
TAGGAACTTGTATGTTGAAATGTTGTATGGTAGTTCTTGTATAGTTAAATAATAATCTTTTTAAGAGTTAATGATAAGCATATGTTATGT
GCATTATTAATAAAATAGTGGCCACTTAGGTAATACCCACTTTTATCTTGTGTGCTGGGTACTCTGGTTACTGAGATAAATAAGGCACTG
GACATCCTCACGTGGAGTTCACAGGCTCATCAGTGAATTCTGTACCACATTTCAACCTTGTTTATTTTAGTTTAATGGAATATACATTCT
TAGTATTGCCTGATTATTTAAATTTGTTGAGGGGGATTGCATGTTGCTTTATTGGCCTGTAAAAATAGCTAGTTTGGTAAGATTTGGTCT
CGCACCTTCCATCTTTGCTACCACATTAAAGATGAGCTTGTTAAAAAGGAAAGCATATTTCTCTGATTGCCCTTATGGAGAAATAAAGAT
AAAATTCAAAGAAACAAATAATATGTGTTGGCATTTCTTGATGCATAGTTGCATCTTTGTTATTCGACATCTCTGATCCTTTTAGACCCC
ATTACATAGGAAATGATGTCTTCTATGAAGACAGGGACCTTGTTTTGTTCCTGGCTATATCTCATGACTTAAACATTCCCTGGCAAATAG
TGAGTGCTTAATAATTGCTTGCCGAATGAACAAATATAAGATCTCAAGTATTCTTTTTTCCTTCATCCCAGTTGGTATAGTGGTTGGCTT

>92714_92714_1_TNIP1-ZWILCH_TNIP1_chr5_150411847_ENST00000523200_ZWILCH_chr15_66820194_ENST00000307897_length(amino acids)=848AA_BP=561
MEGRGPYRIYDPGGSVPSGEASAAFERLVKENSRLKEKMQGIKMLGELLEESQMEATRLRQKAEELVKDNELLPPPSPSLGSFDPLAELT
GKDSNVTASPTAPACPSDKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHANAMALGPLPREDGNLMLHLQRLETTLSVCAEEPDHGQL
FTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRKENEALKAKLDKGLEQRDQAAERLREENLELKKLLMSNGNKEGASGRPGSPKME
GTGKKAVAGQQQASVTAGKVPEVVALGAAEKKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQKITELRQKLADLQKQVTDLEAEREQKQ
RDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVKYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQTPPSSPPTAFGSPEGAGALL
RKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLSNAQLKAFKDEEKAREALRQQKRKAKPEYTWRLPCGG
VRNPNQSSQVMDPPTARPTEPDLNKLDGFGDSTKKDTEVETLKHDTAAVDRSVKRLFKVRSDLDFAEQLWCKMSSSVISYQDLVKCFTLI
IQSLQRGDIQPWLHSGSNSLLSKLIHQSYHGTMDTVSLSGTIPVQMLLEIGLDKLKKDYISFFIGQELASLNHLEYFIAPSVDIQEQVYR
VQKLHHILEILVSCMPFIKSQHELLFSLTQICIKYYKQNPLDEQHIFQLPVRPTAVKNLYQSEKPQKWRVEIYSGQKKIKTVWQLSDSSP

--------------------------------------------------------------
>92714_92714_2_TNIP1-ZWILCH_TNIP1_chr5_150411847_ENST00000523200_ZWILCH_chr15_66820194_ENST00000446801_length(transcript)=3710nt_BP=1684nt
ATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGGCAGCGTGCCCTCAGGAGAGGCATCCGCAGCTTTTGAGCGCCTAGTGAAG
GAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGATGTTAGGGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCGG
CAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCGACCCCCTGGCTGAGCTCACA
GGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGTGGC
ACCTCCTCTGAATTTGAAGTGGTCACTCCTGAGGAGCAGAATTCACCAGAGAGCAGCAGCCATGCCAATGCGATGGCGCTGGGCCCCCTG
CCCCGTGAGGACGGCAACCTGATGCTGCACCTGCAGCGCCTGGAGACCACGCTGAGTGTGTGTGCCGAGGAGCCGGACCACGGCCAGCTC
TTCACCCACCTGGGCCGCATGGCCCTGGAGTTCAACCGACTGGCATCCAAGGTGCACAAGAATGAGCAGCGCACCTCCATTCTGCAGACC
CTGTGTGAGCAGCTTCGGAAGGAGAACGAGGCTCTGAAGGCCAAGTTGGATAAGGGCCTGGAACAGCGGGATCAGGCTGCCGAGAGGCTG
CGGGAGGAAAATTTGGAGCTCAAGAAGTTGTTGATGAGCAATGGCAACAAAGAGGGTGCGTCTGGGCGGCCAGGCTCACCGAAGATGGAA
GGGACAGGCAAGAAGGCAGTGGCTGGACAGCAGCAGGCTAGTGTGACGGCAGGTAAGGTCCCAGAGGTGGTGGCCTTGGGCGCAGCCGAG
AAGAAGGTGAAGATGCTGGAGCAGCAGCGCAGTGAGCTGCTGGAAGTGAACAAGCAGTGGGACCAGCATTTCCGGTCCATGAAGCAGCAG
TATGAGCAGAAGATCACTGAGCTGCGTCAGAAGCTGGCTGATTTGCAGAAGCAGGTGACTGACCTGGAGGCCGAGCGGGAGCAGAAGCAG
CGTGACTTTGACCGCAAGCTCCTCCTGGCCAAGTCCAAGATTGAAATGGAGGAGACCGACAAGGAGCAGCTGACAGCAGAGGCCAAGGAG
CTGCGCCAAAAGGTCAAGTACCTGCAGGATCAGCTGAGCCCACTCACCCGACAGCGTGAGTACCAGGAAAAGGAGATCCAGCGGCTCAAC
AAGGCCCTGGAGGAAGCACTGAGCATCCAAACCCCGCCATCATCTCCACCAACAGCATTTGGGAGCCCAGAAGGAGCAGGGGCCCTCCTA
AGGAAACAGGAGCTGGTCACGCAGAATGAGTTGCTGAAACAGCAGGTGAAGATCTTCGAGGAGGACTTCCAGAGGGAGCGCAGTGATCGT
GAGCGCATGAATGAGGAGAAGGAAGAGCTGAAGAAGCAAGTGGAGAAGCTGCAGGCCCAGGTCACCCTGTCAAATGCCCAGCTAAAAGCA
TTCAAAGATGAGGAGAAGGCAAGAGAAGCCCTCAGACAGCAGAAGAGGAAAGCAAAGCCGGAATACACCTGGCGTCTACCCTGTGGAGGG
GTTCGAAATCCAAATCAGAGCTCCCAAGTGATGGACCCTCCCACAGCCAGGCCTACAGAACCAGACTTAAATAAGCTGGATGGATTTGGT
GATTCTACAAAAAAAGACACTGAGGTTGAGACCTTGAAGCATGACACTGCTGCAGTCGATCGTTCCGTCAAGCGTCTTTTCAAAGTTCGG
AGTGATCTTGATTTTGCTGAGCAACTGTGGTGCAAAATGAGCAGTAGTGTGATTTCATACCAAGACTTGGTGAAGTGTTTCACATTGATC
ATCCAGAGTCTACAACGTGGTGATATACAGCCATGGCTCCATAGTGGAAGTAACAGTTTACTAAGTAAGCTCATTCATCAGTCTTATCAT
GGAACCATGGACACAGTTTCTCTCAGTGGGACTATTCCAGTTCAAATGCTTTTGGAAATTGGTTTGGACAAACTAAAGAAAGATTATATC
AGTTTTTTCATAGGTCAGGAACTTGCATCTTTGAATCATTTGGAATACTTCATTGCTCCATCAGTAGATATACAAGAACAGGTTTATCGT
GTCCAAAAACTCCACCATATTCTAGAAATATTAGTCAGTTGCATGCCTTTCATTAAATCTCAACATGAACTCCTCTTTTCTTTAACACAG
ATCTGCATAAAGTATTACAAACAAAATCCTCTTGATGAGCAACACATTTTTCAGCTGCCAGTCAGACCAACTGCTGTAAAGAACTTATAT
CAAAGTGAGAAGCCACAGAAATGGAGAGTGGAAATATATAGTGGTCAAAAGAAGATTAAGACAGTTTGGCAACTGAGTGACAGCTCACCC
ATAGACCATCTGAATTTTCACAAACCTGATTTTTCGGAATTAACACTAAACGGTAGCCTGGAAGAAAGGATATTCTTTACTAACATGGTT
ACCTGCAGCCAGGTGCATTTCAAGTGAAGTGTGCTGATGAAGTCCTCTATAAGCACAAGCCAAAAAGAGAAAGAGAAAAAAAGGTAATTA
TTGTAGAACCTGAAAACAGCAATGTATGGAAACCCTCAAAGCAGAAAAGGGAGGAAGATCCTGAAGATTCTCTTATGAAGCTCCAAAATT
GATAATCCTGTCTCAGCTCTGCCTCCTCAGGAGGAGCATTAGTAGAACAGCAGTGATGAGGACACAGAGGGAGCAGACAGTGGGTACCAC
GATCTCCGTAACCATTTGCATGTGACTTAGCAAGGGCTCTGAAATGACAAAGAGAACGAGCACCACAAATGAGAACAGGATCATTTTAGT
AAATACAGCTTTATCCCAAAAGCTTTAACTGTATTGGGAAAACTTAAAAAATAGCATCCTCAAATTTTCTGATTCTTATTTGCCATGAAA
TAGAACTTAGTAAATTAAATGTTATTTGAAAATGTTATAAGAGCTTTGTAAATATTTCAGAAAATATGGGATAAATGCCTGAATTTGGTT
CTTCTACAGGTGCTATAATAAAGTCCATCTCTCAATACTTATACTTTCTAAATTCATCTCAGAATATTAGCAGCCATATTCCACAGTTCC
TATAATTTTTACTGGGGGGGATTTGTGATAGGAAAGTCCTTGGGAAACATTTCCAATCTTTCAAAATATTATTGTGTATCTTAAGAAGTA
TAGGAACTTGTATGTTGAAATGTTGTATGGTAGTTCTTGTATAGTTAAATAATAATCTTTTTAAGAGTTAATGATAAGCATATGTTATGT
GCATTATTAATAAAATAGTGGCCACTTAGGTAATACCCACTTTTATCTTGTGTGCTGGGTACTCTGGTTACTGAGATAAATAAGGCACTG
GACATCCTCACGTGGAGTTCACAGGCTCATCAGTGAATTCTGTACCACATTTCAACCTTGTTTATTTTAGTTTAATGGAATATACATTCT
TAGTATTGCCTGATTATTTAAATTTGTTGAGGGGGATTGCATGTTGCTTTATTGGCCTGTAAAAATAGCTAGTTTGGTAAGATTTGGTCT
CGCACCTTCCATCTTTGCTACCACATTAAAGATGAGCTTGTTAAAAAGGAAAGCATATTTCTCTGATTGCCCTTATGGAGAAATAAAGAT

>92714_92714_2_TNIP1-ZWILCH_TNIP1_chr5_150411847_ENST00000523200_ZWILCH_chr15_66820194_ENST00000446801_length(amino acids)=848AA_BP=561
MEGRGPYRIYDPGGSVPSGEASAAFERLVKENSRLKEKMQGIKMLGELLEESQMEATRLRQKAEELVKDNELLPPPSPSLGSFDPLAELT
GKDSNVTASPTAPACPSDKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHANAMALGPLPREDGNLMLHLQRLETTLSVCAEEPDHGQL
FTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRKENEALKAKLDKGLEQRDQAAERLREENLELKKLLMSNGNKEGASGRPGSPKME
GTGKKAVAGQQQASVTAGKVPEVVALGAAEKKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQKITELRQKLADLQKQVTDLEAEREQKQ
RDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVKYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQTPPSSPPTAFGSPEGAGALL
RKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLSNAQLKAFKDEEKAREALRQQKRKAKPEYTWRLPCGG
VRNPNQSSQVMDPPTARPTEPDLNKLDGFGDSTKKDTEVETLKHDTAAVDRSVKRLFKVRSDLDFAEQLWCKMSSSVISYQDLVKCFTLI
IQSLQRGDIQPWLHSGSNSLLSKLIHQSYHGTMDTVSLSGTIPVQMLLEIGLDKLKKDYISFFIGQELASLNHLEYFIAPSVDIQEQVYR
VQKLHHILEILVSCMPFIKSQHELLFSLTQICIKYYKQNPLDEQHIFQLPVRPTAVKNLYQSEKPQKWRVEIYSGQKKIKTVWQLSDSSP

--------------------------------------------------------------
>92714_92714_3_TNIP1-ZWILCH_TNIP1_chr5_150411847_ENST00000523200_ZWILCH_chr15_66820194_ENST00000535141_length(transcript)=2649nt_BP=1684nt
ATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGGCAGCGTGCCCTCAGGAGAGGCATCCGCAGCTTTTGAGCGCCTAGTGAAG
GAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGATGTTAGGGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCGG
CAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCGACCCCCTGGCTGAGCTCACA
GGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGTGGC
ACCTCCTCTGAATTTGAAGTGGTCACTCCTGAGGAGCAGAATTCACCAGAGAGCAGCAGCCATGCCAATGCGATGGCGCTGGGCCCCCTG
CCCCGTGAGGACGGCAACCTGATGCTGCACCTGCAGCGCCTGGAGACCACGCTGAGTGTGTGTGCCGAGGAGCCGGACCACGGCCAGCTC
TTCACCCACCTGGGCCGCATGGCCCTGGAGTTCAACCGACTGGCATCCAAGGTGCACAAGAATGAGCAGCGCACCTCCATTCTGCAGACC
CTGTGTGAGCAGCTTCGGAAGGAGAACGAGGCTCTGAAGGCCAAGTTGGATAAGGGCCTGGAACAGCGGGATCAGGCTGCCGAGAGGCTG
CGGGAGGAAAATTTGGAGCTCAAGAAGTTGTTGATGAGCAATGGCAACAAAGAGGGTGCGTCTGGGCGGCCAGGCTCACCGAAGATGGAA
GGGACAGGCAAGAAGGCAGTGGCTGGACAGCAGCAGGCTAGTGTGACGGCAGGTAAGGTCCCAGAGGTGGTGGCCTTGGGCGCAGCCGAG
AAGAAGGTGAAGATGCTGGAGCAGCAGCGCAGTGAGCTGCTGGAAGTGAACAAGCAGTGGGACCAGCATTTCCGGTCCATGAAGCAGCAG
TATGAGCAGAAGATCACTGAGCTGCGTCAGAAGCTGGCTGATTTGCAGAAGCAGGTGACTGACCTGGAGGCCGAGCGGGAGCAGAAGCAG
CGTGACTTTGACCGCAAGCTCCTCCTGGCCAAGTCCAAGATTGAAATGGAGGAGACCGACAAGGAGCAGCTGACAGCAGAGGCCAAGGAG
CTGCGCCAAAAGGTCAAGTACCTGCAGGATCAGCTGAGCCCACTCACCCGACAGCGTGAGTACCAGGAAAAGGAGATCCAGCGGCTCAAC
AAGGCCCTGGAGGAAGCACTGAGCATCCAAACCCCGCCATCATCTCCACCAACAGCATTTGGGAGCCCAGAAGGAGCAGGGGCCCTCCTA
AGGAAACAGGAGCTGGTCACGCAGAATGAGTTGCTGAAACAGCAGGTGAAGATCTTCGAGGAGGACTTCCAGAGGGAGCGCAGTGATCGT
GAGCGCATGAATGAGGAGAAGGAAGAGCTGAAGAAGCAAGTGGAGAAGCTGCAGGCCCAGGTCACCCTGTCAAATGCCCAGCTAAAAGCA
TTCAAAGATGAGGAGAAGGCAAGAGAAGCCCTCAGACAGCAGAAGAGGAAAGCAAAGCCGGAATACACCTGGCGTCTACCCTGTGGAGGG
GTTCGAAATCCAAATCAGAGCTCCCAAGTGATGGACCCTCCCACAGCCAGGCCTACAGAACCAGACTTAAATAAGCTGGATGGATTTGGT
GATTCTACAAAAAAAGACACTGAGGTTGAGACCTTGAAGCATGACACTGCTGCAGTCGATCGTTCCGTCAAGCGTCTTTTCAAAGTTCGG
AGTGATCTTGATTTTGCTGAGCAACTGTGGTGCAAAATGAGCAGTAGTGTGATTTCATACCAAGACTTGGTGAAGTGTTTCACATTGATC
ATCCAGAGTCTACAACGTGGTGATATACAGCCATGGCTCCATAGTGGAAGTAACAGTTTACTAAGTAAGCTCATTCATCAGTCTTATCAT
GGAACCATGGACACAGTTTCTCTCAGTGGGACTATTCCAGTTCAAATGCTTTTGGAAATTGGTTTGGACAAACTAAAGAAAGATTATATC
AGTTTTTTCATAGGTCAGGAACTTGCATCTTTGAATCATTTGGAATACTTCATTGCTCCATCAGTAGATATACAAGAACAGGTTTATCGT
GTCCAAAAACTCCACCATATTCTAGAAATATTAGTCAGTTGCATGCCTTTCATTAAATCTCAACATGAACTCCTCTTTTCTTTAACACAG
ATCTGCATAAAGTATTACAAACAAAATCCTCTTGATGAGCAACACATTTTTCAGCTGCCAGTCAGACCAACTGCTGTAAAGAACTTATAT
CAAAGTGAGAAGCCACAGAAATGGAGAGTGGAAATATATAGTGGTCAAAAGAAGATTAAGACAGTTTGGCAACTGAGTGACAGCTCACCC
ATAGACCATCTGAATTTTCACAAACCTGATTTTTCGGAATTAACACTAAACGGTAGCCTGGAAGAAAGGATATTCTTTACTAACATGGTT
ACCTGCAGCCAGGTGCATTTCAAGTGAAGTGTGCTGATGAAGTCCTCTATAAGCACAAGCCAAAAAGAGAAAGAGAAAAAAAGGTAATTA

>92714_92714_3_TNIP1-ZWILCH_TNIP1_chr5_150411847_ENST00000523200_ZWILCH_chr15_66820194_ENST00000535141_length(amino acids)=848AA_BP=561
MEGRGPYRIYDPGGSVPSGEASAAFERLVKENSRLKEKMQGIKMLGELLEESQMEATRLRQKAEELVKDNELLPPPSPSLGSFDPLAELT
GKDSNVTASPTAPACPSDKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHANAMALGPLPREDGNLMLHLQRLETTLSVCAEEPDHGQL
FTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRKENEALKAKLDKGLEQRDQAAERLREENLELKKLLMSNGNKEGASGRPGSPKME
GTGKKAVAGQQQASVTAGKVPEVVALGAAEKKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQKITELRQKLADLQKQVTDLEAEREQKQ
RDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVKYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQTPPSSPPTAFGSPEGAGALL
RKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLSNAQLKAFKDEEKAREALRQQKRKAKPEYTWRLPCGG
VRNPNQSSQVMDPPTARPTEPDLNKLDGFGDSTKKDTEVETLKHDTAAVDRSVKRLFKVRSDLDFAEQLWCKMSSSVISYQDLVKCFTLI
IQSLQRGDIQPWLHSGSNSLLSKLIHQSYHGTMDTVSLSGTIPVQMLLEIGLDKLKKDYISFFIGQELASLNHLEYFIAPSVDIQEQVYR
VQKLHHILEILVSCMPFIKSQHELLFSLTQICIKYYKQNPLDEQHIFQLPVRPTAVKNLYQSEKPQKWRVEIYSGQKKIKTVWQLSDSSP

--------------------------------------------------------------
>92714_92714_4_TNIP1-ZWILCH_TNIP1_chr5_150411847_ENST00000523200_ZWILCH_chr15_66820194_ENST00000565627_length(transcript)=2573nt_BP=1684nt
ATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGGCAGCGTGCCCTCAGGAGAGGCATCCGCAGCTTTTGAGCGCCTAGTGAAG
GAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGATGTTAGGGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCGG
CAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCGACCCCCTGGCTGAGCTCACA
GGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGTGGC
ACCTCCTCTGAATTTGAAGTGGTCACTCCTGAGGAGCAGAATTCACCAGAGAGCAGCAGCCATGCCAATGCGATGGCGCTGGGCCCCCTG
CCCCGTGAGGACGGCAACCTGATGCTGCACCTGCAGCGCCTGGAGACCACGCTGAGTGTGTGTGCCGAGGAGCCGGACCACGGCCAGCTC
TTCACCCACCTGGGCCGCATGGCCCTGGAGTTCAACCGACTGGCATCCAAGGTGCACAAGAATGAGCAGCGCACCTCCATTCTGCAGACC
CTGTGTGAGCAGCTTCGGAAGGAGAACGAGGCTCTGAAGGCCAAGTTGGATAAGGGCCTGGAACAGCGGGATCAGGCTGCCGAGAGGCTG
CGGGAGGAAAATTTGGAGCTCAAGAAGTTGTTGATGAGCAATGGCAACAAAGAGGGTGCGTCTGGGCGGCCAGGCTCACCGAAGATGGAA
GGGACAGGCAAGAAGGCAGTGGCTGGACAGCAGCAGGCTAGTGTGACGGCAGGTAAGGTCCCAGAGGTGGTGGCCTTGGGCGCAGCCGAG
AAGAAGGTGAAGATGCTGGAGCAGCAGCGCAGTGAGCTGCTGGAAGTGAACAAGCAGTGGGACCAGCATTTCCGGTCCATGAAGCAGCAG
TATGAGCAGAAGATCACTGAGCTGCGTCAGAAGCTGGCTGATTTGCAGAAGCAGGTGACTGACCTGGAGGCCGAGCGGGAGCAGAAGCAG
CGTGACTTTGACCGCAAGCTCCTCCTGGCCAAGTCCAAGATTGAAATGGAGGAGACCGACAAGGAGCAGCTGACAGCAGAGGCCAAGGAG
CTGCGCCAAAAGGTCAAGTACCTGCAGGATCAGCTGAGCCCACTCACCCGACAGCGTGAGTACCAGGAAAAGGAGATCCAGCGGCTCAAC
AAGGCCCTGGAGGAAGCACTGAGCATCCAAACCCCGCCATCATCTCCACCAACAGCATTTGGGAGCCCAGAAGGAGCAGGGGCCCTCCTA
AGGAAACAGGAGCTGGTCACGCAGAATGAGTTGCTGAAACAGCAGGTGAAGATCTTCGAGGAGGACTTCCAGAGGGAGCGCAGTGATCGT
GAGCGCATGAATGAGGAGAAGGAAGAGCTGAAGAAGCAAGTGGAGAAGCTGCAGGCCCAGGTCACCCTGTCAAATGCCCAGCTAAAAGCA
TTCAAAGATGAGGAGAAGGCAAGAGAAGCCCTCAGACAGCAGAAGAGGAAAGCAAAGCCGGAATACACCTGGCGTCTACCCTGTGGAGGG
GTTCGAAATCCAAATCAGAGCTCCCAAGTGATGGACCCTCCCACAGCCAGGCCTACAGAACCAGACTTAAATAAGCTGGATGGATTTGGT
GATTCTACAAAAAAAGACACTGAGGTTGAGACCTTGAAGCATGACACTGCTGCAGTCGATCGTTCCGTCAAGCGTCTTTTCAAAGTTCGG
AGTGATCTTGATTTTGCTGAGCAACTGTGGTGCAAAATGAGCAGTAGTGTGATTTCATACCAAGACTTGGTGAAGTGTTTCACATTGATC
ATCCAGAGTCTACAACGTGGTGATATACAGCCATGGCTCCATAGTGGAAGTAACAGTTTACTAAGTAAGCTCATTCATCAGTCTTATCAT
GGAACCATGGACACAGTTTCTCTCAGTGGGACTATTCCAGTTCAAATGCTTTTGGAAATTGGTTTGGACAAACTAAAGAAAGATTATATC
AGTTTTTTCATAGGTCAGGAACTTGCATCTTTGAATCATTTGGAATACTTCATTGCTCCATCAGTAGATATACAAGAACAGGTTTATCGT
GTCCAAAAACTCCACCATATTCTAGAAATATTAGTCAGTTGCATGCCTTTCATTAAATCTCAACATGAACTCCTCTTTTCTTTAACACAG
ATCTGCATAAAGTATTACAAACAAAATCCTCTTGATGAGCAACACATTTTTCAGCTGCCAGTCAGACCAACTGCTGTAAAGAACTTATAT
CAAAGTGAGAAGCCACAGAAATGGAGAGTGGAAATATATAGTGGTCAAAAGAAGATTAAGACAGTTTGGCAACTGAGTGACAGCTCACCC
ATAGACCATCTGAATTTTCACAAACCTGATTTTTCGGAATTAACACTAAACGGTAGCCTGGAAGAAAGGATATTCTTTACTAACATGGTT

>92714_92714_4_TNIP1-ZWILCH_TNIP1_chr5_150411847_ENST00000523200_ZWILCH_chr15_66820194_ENST00000565627_length(amino acids)=848AA_BP=561
MEGRGPYRIYDPGGSVPSGEASAAFERLVKENSRLKEKMQGIKMLGELLEESQMEATRLRQKAEELVKDNELLPPPSPSLGSFDPLAELT
GKDSNVTASPTAPACPSDKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHANAMALGPLPREDGNLMLHLQRLETTLSVCAEEPDHGQL
FTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRKENEALKAKLDKGLEQRDQAAERLREENLELKKLLMSNGNKEGASGRPGSPKME
GTGKKAVAGQQQASVTAGKVPEVVALGAAEKKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQKITELRQKLADLQKQVTDLEAEREQKQ
RDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVKYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQTPPSSPPTAFGSPEGAGALL
RKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLSNAQLKAFKDEEKAREALRQQKRKAKPEYTWRLPCGG
VRNPNQSSQVMDPPTARPTEPDLNKLDGFGDSTKKDTEVETLKHDTAAVDRSVKRLFKVRSDLDFAEQLWCKMSSSVISYQDLVKCFTLI
IQSLQRGDIQPWLHSGSNSLLSKLIHQSYHGTMDTVSLSGTIPVQMLLEIGLDKLKKDYISFFIGQELASLNHLEYFIAPSVDIQEQVYR
VQKLHHILEILVSCMPFIKSQHELLFSLTQICIKYYKQNPLDEQHIFQLPVRPTAVKNLYQSEKPQKWRVEIYSGQKKIKTVWQLSDSSP

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Fusion Gene PPI Analysis for TNIP1-ZWILCH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneTNIP1chr5:150411847chr15:66820194ENST00000315050-171894_412625.3333333333334637.0Nef
HgeneTNIP1chr5:150411847chr15:66820194ENST00000389378-171894_412625.3333333333334637.0Nef
HgeneTNIP1chr5:150411847chr15:66820194ENST00000518977-171894_412625.3333333333334636.0Nef
HgeneTNIP1chr5:150411847chr15:66820194ENST00000520931-161794_412572.3333333333334584.0Nef
HgeneTNIP1chr5:150411847chr15:66820194ENST00000521591-171894_412625.3333333333334637.0Nef
HgeneTNIP1chr5:150411847chr15:66820194ENST00000522226-171894_412625.3333333333334637.0Nef
HgeneTNIP1chr5:150411847chr15:66820194ENST00000523338-171894_412625.3333333333334636.0Nef
HgeneTNIP1chr5:150411847chr15:66820194ENST00000315050-1718351_367625.3333333333334637.0Shigella flexneri ipah9.8
HgeneTNIP1chr5:150411847chr15:66820194ENST00000389378-1718351_367625.3333333333334637.0Shigella flexneri ipah9.8
HgeneTNIP1chr5:150411847chr15:66820194ENST00000518977-1718351_367625.3333333333334636.0Shigella flexneri ipah9.8
HgeneTNIP1chr5:150411847chr15:66820194ENST00000520931-1617351_367572.3333333333334584.0Shigella flexneri ipah9.8
HgeneTNIP1chr5:150411847chr15:66820194ENST00000521591-1718351_367625.3333333333334637.0Shigella flexneri ipah9.8
HgeneTNIP1chr5:150411847chr15:66820194ENST00000522226-1718351_367625.3333333333334637.0Shigella flexneri ipah9.8
HgeneTNIP1chr5:150411847chr15:66820194ENST00000523338-1718351_367625.3333333333334636.0Shigella flexneri ipah9.8


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TNIP1-ZWILCH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TNIP1-ZWILCH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource