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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TNKS2-HECTD2 (FusionGDB2 ID:92736)

Fusion Gene Summary for TNKS2-HECTD2

check button Fusion gene summary
Fusion gene informationFusion gene name: TNKS2-HECTD2
Fusion gene ID: 92736
HgeneTgene
Gene symbol

TNKS2

HECTD2

Gene ID

80351

143279

Gene nametankyrase 2HECT domain E3 ubiquitin protein ligase 2
SynonymsARTD6|PARP-5b|PARP-5c|PARP5B|PARP5C|TANK2|TNKL|pART6-
Cytomap

10q23.32

10q23.32

Type of geneprotein-codingprotein-coding
Descriptionpoly [ADP-ribose] polymerase tankyrase-2ADP-ribosyltransferase diphtheria toxin-like 6TNKS-2TRF1-interacting ankyrin-related ADP-ribose polymerase 2poly [ADP-ribose] polymerase 5Bprotein poly-ADP-ribosyltransferase tankyrase-2tankyrase IItankyrase,probable E3 ubiquitin-protein ligase HECTD2HECT domain containing E3 ubiquitin protein ligase 2HECT domain-containing protein 2HECT-type E3 ubiquitin transferase HECTD2
Modification date2020031320200313
UniProtAcc.

Q5U5R9

Ensembl transtripts involved in fusion geneENST00000371627, ENST00000371667, 
ENST00000498446, ENST00000536715, 
ENST00000298068, ENST00000371681, 
ENST00000446394, 
Fusion gene scores* DoF score10 X 8 X 4=3205 X 6 X 6=180
# samples 107
** MAII scorelog2(10/320*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNKS2 [Title/Abstract] AND HECTD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTNKS2(93602148)-HECTD2(93220184), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNKS2

GO:0000209

protein polyubiquitination

19759537|21478859

HgeneTNKS2

GO:0006471

protein ADP-ribosylation

11739745

HgeneTNKS2

GO:0070212

protein poly-ADP-ribosylation

25043379

HgeneTNKS2

GO:0070213

protein auto-ADP-ribosylation

19759537|21478859

HgeneTNKS2

GO:1904355

positive regulation of telomere capping

21531765


check buttonFusion gene breakpoints across TNKS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HECTD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A9WH-01ATNKS2chr10

93602148

-HECTD2chr10

93220184

+
ChimerDB4PRADTCGA-YL-A9WH-01ATNKS2chr10

93602148

+HECTD2chr10

93220184

+
ChimerDB4PRADTCGA-YL-A9WHTNKS2chr10

93602148

+HECTD2chr10

93220184

+


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Fusion Gene ORF analysis for TNKS2-HECTD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000371627ENST00000371667TNKS2chr10

93602148

+HECTD2chr10

93220184

+
5CDS-intronENST00000371627ENST00000498446TNKS2chr10

93602148

+HECTD2chr10

93220184

+
5CDS-intronENST00000371627ENST00000536715TNKS2chr10

93602148

+HECTD2chr10

93220184

+
In-frameENST00000371627ENST00000298068TNKS2chr10

93602148

+HECTD2chr10

93220184

+
In-frameENST00000371627ENST00000371681TNKS2chr10

93602148

+HECTD2chr10

93220184

+
In-frameENST00000371627ENST00000446394TNKS2chr10

93602148

+HECTD2chr10

93220184

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371627TNKS2chr1093602148+ENST00000446394HECTD2chr1093220184+689024389445121472
ENST00000371627TNKS2chr1093602148+ENST00000371681HECTD2chr1093220184+42502438942793899
ENST00000371627TNKS2chr1093602148+ENST00000298068HECTD2chr1093220184+687824389445001468

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371627ENST00000446394TNKS2chr1093602148+HECTD2chr1093220184+0.0001230230.999877
ENST00000371627ENST00000371681TNKS2chr1093602148+HECTD2chr1093220184+0.0003010940.9996989
ENST00000371627ENST00000298068TNKS2chr1093602148+HECTD2chr1093220184+9.06E-050.9999094

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Fusion Genomic Features for TNKS2-HECTD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TNKS2chr1093602148+HECTD2chr1093220183+4.82E-060.99999523
TNKS2chr1093602148+HECTD2chr1093220183+4.82E-060.99999523
TNKS2chr1093602148+HECTD2chr1093220183+4.82E-060.99999523
TNKS2chr1093602148+HECTD2chr1093220183+4.82E-060.99999523

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TNKS2-HECTD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:93602148/chr10:93220184)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HECTD2

Q5U5R9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:28584101}.; FUNCTION: (Microbial infection) Catalyzes ubiquitination of Botulinum neurotoxin A light chain (LC) of C.botulinum neurotoxin type A (BoNT/A). {ECO:0000269|PubMed:28584101}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627545_5536861167.0RegionHIF1AN-binding
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627123_1556861167.0RepeatNote=ANK 3
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627210_2426861167.0RepeatNote=ANK 4
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627243_2756861167.0RepeatNote=ANK 5
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627276_3086861167.0RepeatNote=ANK 6
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627363_3986861167.0RepeatNote=ANK 7
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627399_4316861167.0RepeatNote=ANK 8
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627432_4646861167.0RepeatNote=ANK 9
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627525_5576861167.0RepeatNote=ANK 10
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627558_5906861167.0RepeatNote=ANK 11
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+162757_896861167.0RepeatNote=ANK 1
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627591_6236861167.0RepeatNote=ANK 12
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+162790_1226861167.0RepeatNote=ANK 2
TgeneHECTD2chr10:93602148chr10:93220184ENST00000298068121437_77689777.0DomainHECT
TgeneHECTD2chr10:93602148chr10:93220184ENST0000037168115437_77689208.0DomainHECT

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627873_9366861167.0DomainSAM
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627959_11646861167.0DomainPARP catalytic
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627678_7106861167.0RepeatNote=ANK 13
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627711_7436861167.0RepeatNote=ANK 14
HgeneTNKS2chr10:93602148chr10:93220184ENST00000371627+1627744_7766861167.0RepeatNote=ANK 15


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Fusion Gene Sequence for TNKS2-HECTD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92736_92736_1_TNKS2-HECTD2_TNKS2_chr10_93602148_ENST00000371627_HECTD2_chr10_93220184_ENST00000298068_length(transcript)=6878nt_BP=2438nt
CGCGCCGCCTCGCTAGCCGAAACCTGCCCAGCCGGTGCCCGGCCACTGCGCACGCGCGGGACGACGTCACGTGCGCTCCCGGGGCTGGAC
GGAGCTGGCAGGAGGGGCCTTGCCAGCTTCCGCCGCCGCGTCGTTTCAGGACCCGGACGGCGGATTCGCGCTGCCTCCGCCGCCGCGGGG
CAGCCGGGGGGCAGGGAGCCCAGCGAGGGGCGCGCGTGGGCGCGGCCATGGGACTGCGCCGGATCCGGTGACAGCAGGGAGCCAAGCGGC
CCGGGCCCTGAGCGCGTCTTCTCCGGGGGGCCTCGCCCTCCTGCTCGCGGGGCCGGGGCTCCTGCTCCGGTTGCTGGCGCTGTTGCTGGC
TGTGGCGGCGGCCAGGATCATGTCGGGTCGCCGCTGCGCCGGCGGGGGAGCGGCCTGCGCGAGCGCCGCGGCCGAGGCCGTGGAGCCGGC
CGCCCGAGAGCTGTTCGAGGCGTGCCGCAACGGGGACGTGGAACGAGTCAAGAGGCTGGTGACGCCTGAGAAGGTGAACAGCCGCGACAC
GGCGGGCAGGAAATCCACCCCGCTGCACTTCGCCGCAGGTTTTGGGCGGAAAGACGTAGTTGAATATTTGCTTCAGAATGGTGCAAATGT
CCAAGCACGTGATGATGGGGGCCTTATTCCTCTTCATAATGCATGCTCTTTTGGTCATGCTGAAGTAGTCAATCTCCTTTTGCGACATGG
TGCAGACCCCAATGCTCGAGATAATTGGAATTATACTCCTCTCCATGAAGCTGCAATTAAAGGAAAGATTGATGTTTGCATTGTGCTGTT
ACAGCATGGAGCTGAGCCAACCATCCGAAATACAGATGGAAGGACAGCATTGGATTTAGCAGATCCATCTGCCAAAGCAGTGCTTACTGG
TGAATATAAGAAAGATGAACTCTTAGAAAGTGCCAGGAGTGGCAATGAAGAAAAAATGATGGCTCTACTCACACCATTAAATGTCAACTG
CCACGCAAGTGATGGCAGAAAGTCAACTCCATTACATTTGGCAGCAGGATATAACAGAGTAAAGATTGTACAGCTGTTACTGCAACATGG
AGCTGATGTCCATGCTAAAGATAAAGGTGATCTGGTACCATTACACAATGCCTGTTCTTATGGTCATTATGAAGTAACTGAACTTTTGGT
CAAGCATGGTGCCTGTGTAAATGCAATGGACTTGTGGCAATTCACTCCTCTTCATGAGGCAGCTTCTAAGAACAGGGTTGAAGTATGTTC
TCTTCTCTTAAGTTATGGTGCAGACCCAACACTGCTCAATTGTCACAATAAAAGTGCTATAGACTTGGCTCCCACACCACAGTTAAAAGA
AAGATTAGCATATGAATTTAAAGGCCACTCGTTGCTGCAAGCTGCACGAGAAGCTGATGTTACTCGAATCAAAAAACATCTCTCTCTGGA
AATGGTGAATTTCAAGCATCCTCAAACACATGAAACAGCATTGCATTGTGCTGCTGCATCTCCATATCCCAAAAGAAAGCAAATATGTGA
ACTGTTGCTAAGAAAAGGAGCAAACATCAATGAAAAGACTAAAGAATTCTTGACTCCTCTGCACGTGGCATCTGAGAAAGCTCATAATGA
TGTTGTTGAAGTAGTGGTGAAACATGAAGCAAAGGTTAATGCTCTGGATAATCTTGGTCAGACTTCTCTACACAGAGCTGCATATTGTGG
TCATCTACAAACCTGCCGCCTACTCCTGAGCTATGGGTGTGATCCTAACATTATATCCCTTCAGGGCTTTACTGCTTTACAGATGGGAAA
TGAAAATGTACAGCAACTCCTCCAAGAGGGTATCTCATTAGGTAATTCAGAGGCAGACAGACAATTGCTGGAAGCTGCAAAGGCTGGAGA
TGTCGAAACTGTAAAAAAACTGTGTACTGTTCAGAGTGTCAACTGCAGAGACATTGAAGGGCGTCAGTCTACACCACTTCATTTTGCAGC
TGGGTATAACAGAGTGTCCGTGGTGGAATATCTGCTACAGCATGGAGCTGATGTGCATGCTAAAGATAAAGGAGGCCTTGTACCTTTGCA
CAATGCATGTTCTTATGGACATTATGAAGTTGCAGAACTTCTTGTTAAACATGGAGCAGTAGTTAATGTAGCTGATTTATGGAAATTTAC
ACCTTTACATGAAGCAGCAGCAAAAGGAAAATATGAAATTTGCAAACTTCTGCTCCAGCATGGTGCAGACCCTACAAAAAAAAACAGGGA
TGGAAATACTCCTTTGGATCTTGTTAAAGATGGAGATACAGATATTCAAGATCTGCTTAGGGGAGATGCAGCTTTGCTAGATGCTGCCAA
GAAGGGTTGTTTAGCCAGAGTGAAGAAGTTGTCTTCTCCTGATAATGTAAATTGCCGCGATACCCAAGGCAGACATTCAACACCTTTACA
TTTAGCAGTGAGAGAACCACCACCAATTTGCCTTGATGTTAGACAAAAACAGCGTACATCTATGGATGCATCATCATCCGAAATGAAGGC
CCCAGTCCTTCCAGAACCTATTCTTCCTATCCAGCCCAAAACTGTGAAAGACTTTCAGGAAGATGTAGAAAAAGTTAAGTCATCAGGAGA
TTGGAAAGCAGTACATGATTTTTATCTAACAACGTTTGATTCTTTCCCAGAATTAAATGCTGCATTTAAGAAAGATGCCACTGCCTCATT
TAACACCATTGAAGACTCTGGGATTAATGCTAAATTTGTGAATGCTGTGTATGATACCTTACTTAATACTCCTCAAGACGTTCAGAAGAC
AGTATTAAAGGGAATCATTAACAGCCTGTTACGAGAATGGAAAGGTCCACGAACAAAAGATGATCTTAGAGCATATTTTATACTTTTACA
GAATCCTCAGTTTAATAACACATCTACGTATGTCATCTATGCTCACTTGCTACGACAGATAGCTACCTTAGTGGAAGCTGACCATCATTT
CCTAGTTCACTGGTTTAAAAAATTGTCCCAGAAGAGGTTCAAACAATTGGTAGAGAGATTGCTGCAATTTATTTCTTTACGCCTGTTTCC
TGCAAAGCCTGAAGAATTTCCACCTATAACAAAGTGTTCCTGGTGGATTCCATCAGCCGCTAAAGTGTTGGCTTTACTTAATACTGCAAA
CAATTTAGTTCACCCTCCCCTTATTCCTTATACTGATTTCTATAATTCTACATTGGATCACATTGATCTCATGGAAGAATATCATACTTG
GCAAAACTTTGGAAACTCTCACAGGTTTTCCTTCTGTCAGTACCCATTCGTTATTTCTGTAGCTGCAAAAAAAATCATTATTCAGAGAGA
CTCAGAGCAACAGATGATAAACATCGCAAGGCAAAGTCTGGTGGATAAAGTATCTCGAAGACAGAGACCTGATATGAATATATTATTTCT
AAATATGAAAGTAAGACGGACACATCTGGTTAGCGATTCACTTGATGAGCTAACCCGGAAAAGAGCCGATTTGAAAAAGAAGTTAAAAGT
TACATTTGTAGGGGAAGCTGGTTTGGATATGGGTGGTTTGACTAAAGAATGGTTCCTTCTTCTAATTCGCCAAATTTTTCATCCAGATTA
TGGCATGTTTACATATCACAAGGATTCACACTGCCATTGGTTTAGCAGCTTTAAATGTGATAACTATTCTGAATTCCGATTGGTTGGAAT
TCTTATGGGACTAGCTGTTTATAACAGCATCACCTTGGATATTCGTTTCCCTCCCTGCTGTTACAAGAAATTATTGAGCCCTCCCATCAT
TCCTAGTGATCAAAATATACCAGTAGGCATCTGCAATGTTACCGTGGACGACTTATGTCAAATTATGCCTGAGTTGGCCCATGGATTAAG
TGAACTCTTATCACATGAAGGCAATGTTGAAGAAGATTTCTATTCAACATTTCAGGTTTTTCAAGAAGAATTTGGAATAATCAAGTCCTA
TAATTTAAAGCCCGGTGGTGATAAAATTTCAGTTACCAATCAAAATAGAAAAGAATATGTACAGCTTTATACTGACTTCCTTCTGAACAA
ATCCATCTATAAGCAGTTTGCTGCATTTTATTATGGATTTCATAGTGTGTGTGCTTCAAATGCCCTAATGCTGCTTCGTCCAGAAGAGGT
TGAAATTTTGGTCTGTGGAAGTCCTGACCTGGATATGCATGCTCTGCAGAGAAGTACTCAGTATGATGGCTATGCAAAAACGGACTTAAC
TATAAAATACTTTTGGGATGTTGTGCTTGGATTTCCTCTTGATCTTCAAAAGAAGTTGCTACATTTTACTACAGGGAGTGACAGAGTACC
TGTAGGAGGGATGGCTGATTTGAACTTTAAAATCTCAAAGAATGAAACTTCTACTAACTGCTTACCTGTGGCCCATACCTGCTTCAATCA
ACTTTGCCTTCCCCCCTACAAGAGCAAAAAGGATCTGAAACAGAAATTGATCATTGGAATTTCAAATTCAGAAGGTTTTGGACTTGAGTA
ACCTAGAAGACTTGAAATATAATCTTTTATATGTAGCATTCACTTCCCTCTTACTGTGCCTTTAGCCTTTTCATGTTTCTGTCTCAAAAC
ACTTTGACAAAGCTCACCAACTTTAAAATATTAAGTTTTTAAAAAATCAAATATGAAGTATGTTCAGCAAAGGCATAATTTTCTAAAAAC
ACACACAGAAATCGCTTGAGTGAGGAAAAGTCCACATGGCAGAGACAGGTATGGTCCAGTTCCTCTTTTATATAGCACTTTATCATTCTC
CACAAGTAGTTTGTCACAGGCATTCCACTGGGAAAGCAAAGTACAGTGAAGAATGAATTTATGGTATAGTTGAACCCAGTGGCAGATTGT
ACACTGCTAGCACTGCTAGCACACAGTAGCAAAGCAAACAGCTACATTATCTTTAACATAAGGCATGTAGCCATATTTTCATATAGTGGT
ATACAACACAGTATCATTGCAAATGCAGTTTACAGGGATTTTTGATATACTGGCTTGGGACCTATAAGATTCTTCTCAGCAGTTGCTGAA
AAGCATGTAAATAACTACATAATAGCCTGAGAATAATGGGATTTTGATAGTGCCATTTATTGTTAAAGATTTATTTTTACAAAGTAAATT
CAGGGTTTTAGATGTGTACACAGCTTTTACAAATCAATAAAGATGATTGTACAAGAGTATTTTCAGACTAATTGGATTCAAGGTTATATT
CTTTTAAGTGTTGTTAGTCTGCATGCACATTGGCAGTAAACTAGTTACTTGTGTACTCTGTAATATTTGTATAATGATCATTTCTTCTTA
AGGCTCAAGATATTAGAAAAGAAATCAGACCTAAATAATCATTGATGAAGTATGTCAGTTACAAGCACAAAAGAATATAACTGCTTTTAT
AAATCTTTTGAATCATGTACAAGACTTATATCTACATTTTTTGATCACCAGTTGTACCAAAACACTAATTTTTGAAAAAGATAGGTTAAA
GTATTTGACAAAAGTGAATACAATAATAACACTTGTGTCAAAATGATATAGCTTAGTATAAAAATAAAATTCAACGTTTTGGCCAAAATG
TTTGTTTTTCACTGGATTCTGAATATAATAAATTCAAAGTACCCTTTTTTTAGAGTTTCTAATAAAGTAGTATGTAAAAAGAAACTGCAT
TTTAAGTCAGACAGTAAATGTTTTTTTTAATTTACAGCAAATGAAGCAGTTTTATTAGCATGTTACAAATATTGCCAAACCAAGACTTCT
CTACCATACTTTAACAGCTTTCCTTCAGAAAACTCTGAAGTTATATTTGCAATAATAATGAAACCAGCATTTAGTACCAGCATATGGTTC
ATATGCAAATAATACTTTCCCCAAAATCTTTCTGGGCTAGGCTATTTTCTTGCTATGCTTCCTGCACCCAACCAGCAGAATTCTTCCAGG
GTGGAGGAACTAATCAGCTTGTTCTCCAACAGTTCTGAAGCCAACCCACAAATCTTTGAGGAAAAGGGGTCACTTTGTTTACTATTCTCT
TGGAGATGGAAGTGATTCTGCTCTTCCATTTGGGTATATTATTTCAAGGGTATTTCTTCTTAAAAATCTTGGAAAGCCTAAGAGAGTTAA
AGGCATCCTGGTTTTGTTTCATTTTGCTCTGTTTTAAATCCATATGCAAATAAAACTGCTTCTCTCTTACACTGCTTGAACTAGAAAATC
AGCTTTTTAATGTAGGTTACCACTTATAAGCACAAAAGAAACATGTATAAGAAACCAGATTTAAGTGTTTTAAATAAAATGTAAACAGTT
TTTATTTGGTAGAGATGACTCATGGAAAAATTGTGTTGGCTTGGTCTGCATGTTTAATGATGTGCTTGTATATCGATTAGCTGTGTCACT
TTTAAATAAGAAGTCCACACAAGCAAGCCAAATTTTTAGATGACGAAGTCCATAAATAACTAGAGAATTTTTGTTATCTGTTGTTAAGTT
GAAATGTATAATCATTTATCACTAAATTGCACATTGCCTTTATTTATTTGTGCTCTGTTTTTGGTTTACAGTGTAATAATACCTCATTTA
AAAAATAAAAACCACTACTGTTACATTTTATTAATTTAAAAAGCTAGAAAATTCATGTAGTTACTTTTTTTACATATATAATCTGTTAAT
GAATTATTGATTTTTGTATCTGCCACAGTAAATTAAAGCATTACACAGTATTTATCAGTATTTTTTAAACATCCTGTCCTTTTTTAAAAT
CTTTGCTTAGTCAGTCATATTTTTGTCTGTATGATTAGAAGTTTTTACGTCCTTCCTTTTTTGTACAAATCTGTATTGTATTAATTTCTG

>92736_92736_1_TNKS2-HECTD2_TNKS2_chr10_93602148_ENST00000371627_HECTD2_chr10_93220184_ENST00000298068_length(amino acids)=1468AA_BP=781
MAGGALPASAAASFQDPDGGFALPPPPRGSRGAGSPARGARGRGHGTAPDPVTAGSQAARALSASSPGGLALLLAGPGLLLRLLALLLAV
AAARIMSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ
ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGE
YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK
HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM
VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH
LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG
YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG
NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAVREPPPICLDVRQKQRTSMDASSSEMKAP
VLPEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTIEDSGINAKFVNAVYDTLLNTPQDVQKTV
LKGIINSLLREWKGPRTKDDLRAYFILLQNPQFNNTSTYVIYAHLLRQIATLVEADHHFLVHWFKKLSQKRFKQLVERLLQFISLRLFPA
KPEEFPPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDS
EQQMINIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELTRKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYG
MFTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSE
LLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVE
ILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCFNQL

--------------------------------------------------------------
>92736_92736_2_TNKS2-HECTD2_TNKS2_chr10_93602148_ENST00000371627_HECTD2_chr10_93220184_ENST00000371681_length(transcript)=4250nt_BP=2438nt
CGCGCCGCCTCGCTAGCCGAAACCTGCCCAGCCGGTGCCCGGCCACTGCGCACGCGCGGGACGACGTCACGTGCGCTCCCGGGGCTGGAC
GGAGCTGGCAGGAGGGGCCTTGCCAGCTTCCGCCGCCGCGTCGTTTCAGGACCCGGACGGCGGATTCGCGCTGCCTCCGCCGCCGCGGGG
CAGCCGGGGGGCAGGGAGCCCAGCGAGGGGCGCGCGTGGGCGCGGCCATGGGACTGCGCCGGATCCGGTGACAGCAGGGAGCCAAGCGGC
CCGGGCCCTGAGCGCGTCTTCTCCGGGGGGCCTCGCCCTCCTGCTCGCGGGGCCGGGGCTCCTGCTCCGGTTGCTGGCGCTGTTGCTGGC
TGTGGCGGCGGCCAGGATCATGTCGGGTCGCCGCTGCGCCGGCGGGGGAGCGGCCTGCGCGAGCGCCGCGGCCGAGGCCGTGGAGCCGGC
CGCCCGAGAGCTGTTCGAGGCGTGCCGCAACGGGGACGTGGAACGAGTCAAGAGGCTGGTGACGCCTGAGAAGGTGAACAGCCGCGACAC
GGCGGGCAGGAAATCCACCCCGCTGCACTTCGCCGCAGGTTTTGGGCGGAAAGACGTAGTTGAATATTTGCTTCAGAATGGTGCAAATGT
CCAAGCACGTGATGATGGGGGCCTTATTCCTCTTCATAATGCATGCTCTTTTGGTCATGCTGAAGTAGTCAATCTCCTTTTGCGACATGG
TGCAGACCCCAATGCTCGAGATAATTGGAATTATACTCCTCTCCATGAAGCTGCAATTAAAGGAAAGATTGATGTTTGCATTGTGCTGTT
ACAGCATGGAGCTGAGCCAACCATCCGAAATACAGATGGAAGGACAGCATTGGATTTAGCAGATCCATCTGCCAAAGCAGTGCTTACTGG
TGAATATAAGAAAGATGAACTCTTAGAAAGTGCCAGGAGTGGCAATGAAGAAAAAATGATGGCTCTACTCACACCATTAAATGTCAACTG
CCACGCAAGTGATGGCAGAAAGTCAACTCCATTACATTTGGCAGCAGGATATAACAGAGTAAAGATTGTACAGCTGTTACTGCAACATGG
AGCTGATGTCCATGCTAAAGATAAAGGTGATCTGGTACCATTACACAATGCCTGTTCTTATGGTCATTATGAAGTAACTGAACTTTTGGT
CAAGCATGGTGCCTGTGTAAATGCAATGGACTTGTGGCAATTCACTCCTCTTCATGAGGCAGCTTCTAAGAACAGGGTTGAAGTATGTTC
TCTTCTCTTAAGTTATGGTGCAGACCCAACACTGCTCAATTGTCACAATAAAAGTGCTATAGACTTGGCTCCCACACCACAGTTAAAAGA
AAGATTAGCATATGAATTTAAAGGCCACTCGTTGCTGCAAGCTGCACGAGAAGCTGATGTTACTCGAATCAAAAAACATCTCTCTCTGGA
AATGGTGAATTTCAAGCATCCTCAAACACATGAAACAGCATTGCATTGTGCTGCTGCATCTCCATATCCCAAAAGAAAGCAAATATGTGA
ACTGTTGCTAAGAAAAGGAGCAAACATCAATGAAAAGACTAAAGAATTCTTGACTCCTCTGCACGTGGCATCTGAGAAAGCTCATAATGA
TGTTGTTGAAGTAGTGGTGAAACATGAAGCAAAGGTTAATGCTCTGGATAATCTTGGTCAGACTTCTCTACACAGAGCTGCATATTGTGG
TCATCTACAAACCTGCCGCCTACTCCTGAGCTATGGGTGTGATCCTAACATTATATCCCTTCAGGGCTTTACTGCTTTACAGATGGGAAA
TGAAAATGTACAGCAACTCCTCCAAGAGGGTATCTCATTAGGTAATTCAGAGGCAGACAGACAATTGCTGGAAGCTGCAAAGGCTGGAGA
TGTCGAAACTGTAAAAAAACTGTGTACTGTTCAGAGTGTCAACTGCAGAGACATTGAAGGGCGTCAGTCTACACCACTTCATTTTGCAGC
TGGGTATAACAGAGTGTCCGTGGTGGAATATCTGCTACAGCATGGAGCTGATGTGCATGCTAAAGATAAAGGAGGCCTTGTACCTTTGCA
CAATGCATGTTCTTATGGACATTATGAAGTTGCAGAACTTCTTGTTAAACATGGAGCAGTAGTTAATGTAGCTGATTTATGGAAATTTAC
ACCTTTACATGAAGCAGCAGCAAAAGGAAAATATGAAATTTGCAAACTTCTGCTCCAGCATGGTGCAGACCCTACAAAAAAAAACAGGGA
TGGAAATACTCCTTTGGATCTTGTTAAAGATGGAGATACAGATATTCAAGATCTGCTTAGGGGAGATGCAGCTTTGCTAGATGCTGCCAA
GAAGGGTTGTTTAGCCAGAGTGAAGAAGTTGTCTTCTCCTGATAATGTAAATTGCCGCGATACCCAAGGCAGACATTCAACACCTTTACA
TTTAGCAGTGAGAGAACCACCACCAATTTGCCTTGATGTTAGACAAAAACAGCGTACATCTATGGATGCATCATCATCCGAAATGAAGGC
CCCAGTCCTTCCAGAACCTATTCTTCCTATCCAGCCCAAAACTGTGAAAGACTTTCAGGAAGATGTAGAAAAAGTTAAGTCATCAGGAGA
TTGGAAAGCAGTACATGATTTTTATCTAACAACGTTTGATTCTTTCCCAGAATTAAATGCTGCATTTAAGAAAGATGCCACTGCCTCATT
TAACACCATTGAAGACTCTGGGATTAATGCTAAATTTGTGAATGCTGTGTATGATACCTTACTTAATACTGTAAGTATTATGACATGCAA
GTAATATTATTCTGTGTCTCTTCTGTATATCAAAAGCAGCCATACAAATATTGTAAAAATCACCTTATAATTACCTTAGAAACTCTGATA
CAATTTTATAGTAAATGTAGCTGGAATTCTCATAAAGTTAGATTATTTTATTCTTTTATTTTTTAATTATGAATTAAGCAGCAAATACTT
TTATATCCAATCCTTTTTTAGAAAGACTTGCTAAAATCATGCTTTACTTACTCAGCAAAAGGAGGTAAGTTATTTAATTATATTGGAATT
ACACTGAATCTGTAGATCAGTGGTTCTTAAACATTAGCCTGTATCAGAATCACAAGAAGGGCTTGTTAAAATACAGAATTTCAGATTCAG
TAGGTCTTGGGTGAAGCCCAAGAATTTTCATTTGTAACAAGTTCCCAGGATATGTTGATTTATGAGTTCATTTATGATGTGACACATACT
ATAAAAATTATGTCACCATTCAAAAAATCCAGATGCATATTTGAAGGACTAAGTGGGAATGATAAAGACAGAATGTAAACAAAGTCTCCA
GAAGTTTAGCTATGAAGTGAAAGACATGTTAAGAATGACCACATTTTGAGAACCATACTGCTATAGATCAATTTGTGAAAAATTGACATC
TTTTCAATCCATAAGCATACTGTATCCTTTTAGGTACCTAGGTCTTCTTTAATTTCTCTTGGTAATGTTTTGTAGTTTTCTGGATAGAGG
TGTTACACATTTCTCATTACATGTATTTCTAGGTACTTCATTTTTTTTATCCTATTATAATTTTATTTTCCAATTGTGACTAATATATGG
AAATACTTTCATATATTTATCTTTATCTAAATACAGTTGACCCTTGAACAATGCGAGGGTTAGGGGCGCTAACCCCCTATGCAGTAAAAA
AAAAAATCTGTGTATAACTTTTGACTCCCCAGAAGCTTAACTACTAATAACCTATTGTTGACCAGAAGTCTTACTGATAACATAAACAGT
CAATTAACGTATATTTTATGTTATATGTATTCTATACTATATTGTTACAATAAAGTAAGCTAAGGAAAAGGCAATGTTATTAAGAAAAAA
TAAGGAAGATAAAATATATTTACTATATATTAAGTGGAAGTGGACTATCATAAAGGTCTTCATCCTTATTGAGTAGGCTGAGGAAGAGGA
GGGGTTGGTCTTGCTGTCTCAGGTGGCAGAGGTGAAAGAAAATAATGTATATAAGCAGACTTGCACAATTCAAGCCTGTATTCAAGAGTC
AACTGTACTTTGCTATATTCATCCATTAATTCTAATAGTACATCAGTAAATTAACTTGGATTTTCTGTGTACACAATCTTGTCATTTGTG
AAAAAGGAGAGTTTTATCTCCTTCTAATCCTGTATCTTATATGGATATATGTATGTGTTTGCATTGACTGGGACCTCTTTCACAATTGTG

>92736_92736_2_TNKS2-HECTD2_TNKS2_chr10_93602148_ENST00000371627_HECTD2_chr10_93220184_ENST00000371681_length(amino acids)=899AA_BP=781
MAGGALPASAAASFQDPDGGFALPPPPRGSRGAGSPARGARGRGHGTAPDPVTAGSQAARALSASSPGGLALLLAGPGLLLRLLALLLAV
AAARIMSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ
ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGE
YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK
HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM
VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH
LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG
YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG
NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAVREPPPICLDVRQKQRTSMDASSSEMKAP

--------------------------------------------------------------
>92736_92736_3_TNKS2-HECTD2_TNKS2_chr10_93602148_ENST00000371627_HECTD2_chr10_93220184_ENST00000446394_length(transcript)=6890nt_BP=2438nt
CGCGCCGCCTCGCTAGCCGAAACCTGCCCAGCCGGTGCCCGGCCACTGCGCACGCGCGGGACGACGTCACGTGCGCTCCCGGGGCTGGAC
GGAGCTGGCAGGAGGGGCCTTGCCAGCTTCCGCCGCCGCGTCGTTTCAGGACCCGGACGGCGGATTCGCGCTGCCTCCGCCGCCGCGGGG
CAGCCGGGGGGCAGGGAGCCCAGCGAGGGGCGCGCGTGGGCGCGGCCATGGGACTGCGCCGGATCCGGTGACAGCAGGGAGCCAAGCGGC
CCGGGCCCTGAGCGCGTCTTCTCCGGGGGGCCTCGCCCTCCTGCTCGCGGGGCCGGGGCTCCTGCTCCGGTTGCTGGCGCTGTTGCTGGC
TGTGGCGGCGGCCAGGATCATGTCGGGTCGCCGCTGCGCCGGCGGGGGAGCGGCCTGCGCGAGCGCCGCGGCCGAGGCCGTGGAGCCGGC
CGCCCGAGAGCTGTTCGAGGCGTGCCGCAACGGGGACGTGGAACGAGTCAAGAGGCTGGTGACGCCTGAGAAGGTGAACAGCCGCGACAC
GGCGGGCAGGAAATCCACCCCGCTGCACTTCGCCGCAGGTTTTGGGCGGAAAGACGTAGTTGAATATTTGCTTCAGAATGGTGCAAATGT
CCAAGCACGTGATGATGGGGGCCTTATTCCTCTTCATAATGCATGCTCTTTTGGTCATGCTGAAGTAGTCAATCTCCTTTTGCGACATGG
TGCAGACCCCAATGCTCGAGATAATTGGAATTATACTCCTCTCCATGAAGCTGCAATTAAAGGAAAGATTGATGTTTGCATTGTGCTGTT
ACAGCATGGAGCTGAGCCAACCATCCGAAATACAGATGGAAGGACAGCATTGGATTTAGCAGATCCATCTGCCAAAGCAGTGCTTACTGG
TGAATATAAGAAAGATGAACTCTTAGAAAGTGCCAGGAGTGGCAATGAAGAAAAAATGATGGCTCTACTCACACCATTAAATGTCAACTG
CCACGCAAGTGATGGCAGAAAGTCAACTCCATTACATTTGGCAGCAGGATATAACAGAGTAAAGATTGTACAGCTGTTACTGCAACATGG
AGCTGATGTCCATGCTAAAGATAAAGGTGATCTGGTACCATTACACAATGCCTGTTCTTATGGTCATTATGAAGTAACTGAACTTTTGGT
CAAGCATGGTGCCTGTGTAAATGCAATGGACTTGTGGCAATTCACTCCTCTTCATGAGGCAGCTTCTAAGAACAGGGTTGAAGTATGTTC
TCTTCTCTTAAGTTATGGTGCAGACCCAACACTGCTCAATTGTCACAATAAAAGTGCTATAGACTTGGCTCCCACACCACAGTTAAAAGA
AAGATTAGCATATGAATTTAAAGGCCACTCGTTGCTGCAAGCTGCACGAGAAGCTGATGTTACTCGAATCAAAAAACATCTCTCTCTGGA
AATGGTGAATTTCAAGCATCCTCAAACACATGAAACAGCATTGCATTGTGCTGCTGCATCTCCATATCCCAAAAGAAAGCAAATATGTGA
ACTGTTGCTAAGAAAAGGAGCAAACATCAATGAAAAGACTAAAGAATTCTTGACTCCTCTGCACGTGGCATCTGAGAAAGCTCATAATGA
TGTTGTTGAAGTAGTGGTGAAACATGAAGCAAAGGTTAATGCTCTGGATAATCTTGGTCAGACTTCTCTACACAGAGCTGCATATTGTGG
TCATCTACAAACCTGCCGCCTACTCCTGAGCTATGGGTGTGATCCTAACATTATATCCCTTCAGGGCTTTACTGCTTTACAGATGGGAAA
TGAAAATGTACAGCAACTCCTCCAAGAGGGTATCTCATTAGGTAATTCAGAGGCAGACAGACAATTGCTGGAAGCTGCAAAGGCTGGAGA
TGTCGAAACTGTAAAAAAACTGTGTACTGTTCAGAGTGTCAACTGCAGAGACATTGAAGGGCGTCAGTCTACACCACTTCATTTTGCAGC
TGGGTATAACAGAGTGTCCGTGGTGGAATATCTGCTACAGCATGGAGCTGATGTGCATGCTAAAGATAAAGGAGGCCTTGTACCTTTGCA
CAATGCATGTTCTTATGGACATTATGAAGTTGCAGAACTTCTTGTTAAACATGGAGCAGTAGTTAATGTAGCTGATTTATGGAAATTTAC
ACCTTTACATGAAGCAGCAGCAAAAGGAAAATATGAAATTTGCAAACTTCTGCTCCAGCATGGTGCAGACCCTACAAAAAAAAACAGGGA
TGGAAATACTCCTTTGGATCTTGTTAAAGATGGAGATACAGATATTCAAGATCTGCTTAGGGGAGATGCAGCTTTGCTAGATGCTGCCAA
GAAGGGTTGTTTAGCCAGAGTGAAGAAGTTGTCTTCTCCTGATAATGTAAATTGCCGCGATACCCAAGGCAGACATTCAACACCTTTACA
TTTAGCAGTGAGAGAACCACCACCAATTTGCCTTGATGTTAGACAAAAACAGCGTACATCTATGGATGCATCATCATCCGAAATGAAGGC
CCCAGTCCTTCCAGAACCTATTCTTCCTATCCAGCCCAAAACTGTGAAAGACTTTCAGGAAGATGTAGAAAAAGTTAAGTCATCAGGAGA
TTGGAAAGCAGTACATGATTTTTATCTAACAACGTTTGATTCTTTCCCAGAATTAAATGCTGCATTTAAGAAAGATGCCACTGCCTCATT
TAACACCATTGAAGACTCTGGGATTAATGCTAAATTTGTGAATGCTGTGTATGATACCTTACTTAATACTCCTCAAGACGTTCAGAAGAC
AGTATTAAAGGGAATCATTAACAGCCTGTTACGAGAATGGAAAGGTCCACGAACAAAAGATGATCTTAGAGCATATTTTATACTTTTACA
GAATCCTCAGTTTAATAACACATCTACGTATGTCATCTATGCTCACTTGCTACGACAGATAGCTACCTTAGTGGAAGCTGACCATCATTT
CCTAGTTCACTGGTTTAAAAAACAGTATTCAAGATTGTCCCAGAAGAGGTTCAAACAATTGGTAGAGAGATTGCTGCAATTTATTTCTTT
ACGCCTGTTTCCTGCAAAGCCTGAAGAATTTCCACCTATAACAAAGTGTTCCTGGTGGATTCCATCAGCCGCTAAAGTGTTGGCTTTACT
TAATACTGCAAACAATTTAGTTCACCCTCCCCTTATTCCTTATACTGATTTCTATAATTCTACATTGGATCACATTGATCTCATGGAAGA
ATATCATACTTGGCAAAACTTTGGAAACTCTCACAGGTTTTCCTTCTGTCAGTACCCATTCGTTATTTCTGTAGCTGCAAAAAAAATCAT
TATTCAGAGAGACTCAGAGCAACAGATGATAAACATCGCAAGGCAAAGTCTGGTGGATAAAGTATCTCGAAGACAGAGACCTGATATGAA
TATATTATTTCTAAATATGAAAGTAAGACGGACACATCTGGTTAGCGATTCACTTGATGAGCTAACCCGGAAAAGAGCCGATTTGAAAAA
GAAGTTAAAAGTTACATTTGTAGGGGAAGCTGGTTTGGATATGGGTGGTTTGACTAAAGAATGGTTCCTTCTTCTAATTCGCCAAATTTT
TCATCCAGATTATGGCATGTTTACATATCACAAGGATTCACACTGCCATTGGTTTAGCAGCTTTAAATGTGATAACTATTCTGAATTCCG
ATTGGTTGGAATTCTTATGGGACTAGCTGTTTATAACAGCATCACCTTGGATATTCGTTTCCCTCCCTGCTGTTACAAGAAATTATTGAG
CCCTCCCATCATTCCTAGTGATCAAAATATACCAGTAGGCATCTGCAATGTTACCGTGGACGACTTATGTCAAATTATGCCTGAGTTGGC
CCATGGATTAAGTGAACTCTTATCACATGAAGGCAATGTTGAAGAAGATTTCTATTCAACATTTCAGGTTTTTCAAGAAGAATTTGGAAT
AATCAAGTCCTATAATTTAAAGCCCGGTGGTGATAAAATTTCAGTTACCAATCAAAATAGAAAAGAATATGTACAGCTTTATACTGACTT
CCTTCTGAACAAATCCATCTATAAGCAGTTTGCTGCATTTTATTATGGATTTCATAGTGTGTGTGCTTCAAATGCCCTAATGCTGCTTCG
TCCAGAAGAGGTTGAAATTTTGGTCTGTGGAAGTCCTGACCTGGATATGCATGCTCTGCAGAGAAGTACTCAGTATGATGGCTATGCAAA
AACGGACTTAACTATAAAATACTTTTGGGATGTTGTGCTTGGATTTCCTCTTGATCTTCAAAAGAAGTTGCTACATTTTACTACAGGGAG
TGACAGAGTACCTGTAGGAGGGATGGCTGATTTGAACTTTAAAATCTCAAAGAATGAAACTTCTACTAACTGCTTACCTGTGGCCCATAC
CTGCTTCAATCAACTTTGCCTTCCCCCCTACAAGAGCAAAAAGGATCTGAAACAGAAATTGATCATTGGAATTTCAAATTCAGAAGGTTT
TGGACTTGAGTAACCTAGAAGACTTGAAATATAATCTTTTATATGTAGCATTCACTTCCCTCTTACTGTGCCTTTAGCCTTTTCATGTTT
CTGTCTCAAAACACTTTGACAAAGCTCACCAACTTTAAAATATTAAGTTTTTAAAAAATCAAATATGAAGTATGTTCAGCAAAGGCATAA
TTTTCTAAAAACACACACAGAAATCGCTTGAGTGAGGAAAAGTCCACATGGCAGAGACAGGTATGGTCCAGTTCCTCTTTTATATAGCAC
TTTATCATTCTCCACAAGTAGTTTGTCACAGGCATTCCACTGGGAAAGCAAAGTACAGTGAAGAATGAATTTATGGTATAGTTGAACCCA
GTGGCAGATTGTACACTGCTAGCACTGCTAGCACACAGTAGCAAAGCAAACAGCTACATTATCTTTAACATAAGGCATGTAGCCATATTT
TCATATAGTGGTATACAACACAGTATCATTGCAAATGCAGTTTACAGGGATTTTTGATATACTGGCTTGGGACCTATAAGATTCTTCTCA
GCAGTTGCTGAAAAGCATGTAAATAACTACATAATAGCCTGAGAATAATGGGATTTTGATAGTGCCATTTATTGTTAAAGATTTATTTTT
ACAAAGTAAATTCAGGGTTTTAGATGTGTACACAGCTTTTACAAATCAATAAAGATGATTGTACAAGAGTATTTTCAGACTAATTGGATT
CAAGGTTATATTCTTTTAAGTGTTGTTAGTCTGCATGCACATTGGCAGTAAACTAGTTACTTGTGTACTCTGTAATATTTGTATAATGAT
CATTTCTTCTTAAGGCTCAAGATATTAGAAAAGAAATCAGACCTAAATAATCATTGATGAAGTATGTCAGTTACAAGCACAAAAGAATAT
AACTGCTTTTATAAATCTTTTGAATCATGTACAAGACTTATATCTACATTTTTTGATCACCAGTTGTACCAAAACACTAATTTTTGAAAA
AGATAGGTTAAAGTATTTGACAAAAGTGAATACAATAATAACACTTGTGTCAAAATGATATAGCTTAGTATAAAAATAAAATTCAACGTT
TTGGCCAAAATGTTTGTTTTTCACTGGATTCTGAATATAATAAATTCAAAGTACCCTTTTTTTAGAGTTTCTAATAAAGTAGTATGTAAA
AAGAAACTGCATTTTAAGTCAGACAGTAAATGTTTTTTTTAATTTACAGCAAATGAAGCAGTTTTATTAGCATGTTACAAATATTGCCAA
ACCAAGACTTCTCTACCATACTTTAACAGCTTTCCTTCAGAAAACTCTGAAGTTATATTTGCAATAATAATGAAACCAGCATTTAGTACC
AGCATATGGTTCATATGCAAATAATACTTTCCCCAAAATCTTTCTGGGCTAGGCTATTTTCTTGCTATGCTTCCTGCACCCAACCAGCAG
AATTCTTCCAGGGTGGAGGAACTAATCAGCTTGTTCTCCAACAGTTCTGAAGCCAACCCACAAATCTTTGAGGAAAAGGGGTCACTTTGT
TTACTATTCTCTTGGAGATGGAAGTGATTCTGCTCTTCCATTTGGGTATATTATTTCAAGGGTATTTCTTCTTAAAAATCTTGGAAAGCC
TAAGAGAGTTAAAGGCATCCTGGTTTTGTTTCATTTTGCTCTGTTTTAAATCCATATGCAAATAAAACTGCTTCTCTCTTACACTGCTTG
AACTAGAAAATCAGCTTTTTAATGTAGGTTACCACTTATAAGCACAAAAGAAACATGTATAAGAAACCAGATTTAAGTGTTTTAAATAAA
ATGTAAACAGTTTTTATTTGGTAGAGATGACTCATGGAAAAATTGTGTTGGCTTGGTCTGCATGTTTAATGATGTGCTTGTATATCGATT
AGCTGTGTCACTTTTAAATAAGAAGTCCACACAAGCAAGCCAAATTTTTAGATGACGAAGTCCATAAATAACTAGAGAATTTTTGTTATC
TGTTGTTAAGTTGAAATGTATAATCATTTATCACTAAATTGCACATTGCCTTTATTTATTTGTGCTCTGTTTTTGGTTTACAGTGTAATA
ATACCTCATTTAAAAAATAAAAACCACTACTGTTACATTTTATTAATTTAAAAAGCTAGAAAATTCATGTAGTTACTTTTTTTACATATA
TAATCTGTTAATGAATTATTGATTTTTGTATCTGCCACAGTAAATTAAAGCATTACACAGTATTTATCAGTATTTTTTAAACATCCTGTC
CTTTTTTAAAATCTTTGCTTAGTCAGTCATATTTTTGTCTGTATGATTAGAAGTTTTTACGTCCTTCCTTTTTTGTACAAATCTGTATTG

>92736_92736_3_TNKS2-HECTD2_TNKS2_chr10_93602148_ENST00000371627_HECTD2_chr10_93220184_ENST00000446394_length(amino acids)=1472AA_BP=781
MAGGALPASAAASFQDPDGGFALPPPPRGSRGAGSPARGARGRGHGTAPDPVTAGSQAARALSASSPGGLALLLAGPGLLLRLLALLLAV
AAARIMSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ
ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGE
YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK
HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM
VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH
LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG
YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG
NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAVREPPPICLDVRQKQRTSMDASSSEMKAP
VLPEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTIEDSGINAKFVNAVYDTLLNTPQDVQKTV
LKGIINSLLREWKGPRTKDDLRAYFILLQNPQFNNTSTYVIYAHLLRQIATLVEADHHFLVHWFKKQYSRLSQKRFKQLVERLLQFISLR
LFPAKPEEFPPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIII
QRDSEQQMINIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELTRKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFH
PDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAH
GLSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRP
EEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TNKS2-HECTD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TNKS2-HECTD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TNKS2-HECTD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource