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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TNPO2-DNASE2 (FusionGDB2 ID:92795)

Fusion Gene Summary for TNPO2-DNASE2

check button Fusion gene summary
Fusion gene informationFusion gene name: TNPO2-DNASE2
Fusion gene ID: 92795
HgeneTgene
Gene symbol

TNPO2

DNASE2

Gene ID

30000

1777

Gene nametransportin 2deoxyribonuclease 2, lysosomal
SynonymsIPO3|KPNB2B|TRN2DNASE2A|DNL|DNL2
Cytomap

19p13.13

19p13.13

Type of geneprotein-codingprotein-coding
Descriptiontransportin-2importin 3karyopherin beta 2b, transportinkaryopherin beta-2btransportin 2 (importin 3, karyopherin beta 2b)deoxyribonuclease-2-alphaDNase II alphaDNase II, lysosomalR31240_2acid DNasedeoxyribonuclease II alphadeoxyribonuclease II, lysosomallysosomal DNase II
Modification date2020031320200313
UniProtAcc.

O00115

Ensembl transtripts involved in fusion geneENST00000356861, ENST00000425528, 
ENST00000441499, ENST00000450764, 
ENST00000588216, ENST00000592287, 
ENST00000589956, 		ENST00000222219, 
ENST00000538460, 
Fusion gene scores* DoF score19 X 19 X 8=28883 X 3 X 3=27
# samples 244
** MAII scorelog2(24/2888*10)=-3.58896443127865
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TNPO2 [Title/Abstract] AND DNASE2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTNPO2(12816054)-DNASE2(12987177), # samples:3
Anticipated loss of major functional domain due to fusion event.TNPO2-DNASE2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TNPO2-DNASE2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TNPO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNASE2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-43-5670-01ATNPO2chr19

12816054

-DNASE2chr19

12987177

-
ChimerDB4LUSCTCGA-43-5670TNPO2chr19

12816053

-DNASE2chr19

12987177

-
ChimerDB4LUSCTCGA-43-5670TNPO2chr19

12816054

-DNASE2chr19

12987177

-


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Fusion Gene ORF analysis for TNPO2-DNASE2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000356861ENST00000222219TNPO2chr19

12816054

-DNASE2chr19

12987177

-
Frame-shiftENST00000356861ENST00000222219TNPO2chr19

12816053

-DNASE2chr19

12987177

-
Frame-shiftENST00000425528ENST00000222219TNPO2chr19

12816054

-DNASE2chr19

12987177

-
Frame-shiftENST00000425528ENST00000222219TNPO2chr19

12816053

-DNASE2chr19

12987177

-
Frame-shiftENST00000441499ENST00000222219TNPO2chr19

12816054

-DNASE2chr19

12987177

-
Frame-shiftENST00000441499ENST00000222219TNPO2chr19

12816053

-DNASE2chr19

12987177

-
Frame-shiftENST00000450764ENST00000222219TNPO2chr19

12816054

-DNASE2chr19

12987177

-
Frame-shiftENST00000450764ENST00000222219TNPO2chr19

12816053

-DNASE2chr19

12987177

-
Frame-shiftENST00000588216ENST00000222219TNPO2chr19

12816054

-DNASE2chr19

12987177

-
Frame-shiftENST00000588216ENST00000222219TNPO2chr19

12816053

-DNASE2chr19

12987177

-
Frame-shiftENST00000592287ENST00000538460TNPO2chr19

12816054

-DNASE2chr19

12987177

-
Frame-shiftENST00000592287ENST00000538460TNPO2chr19

12816053

-DNASE2chr19

12987177

-
In-frameENST00000356861ENST00000538460TNPO2chr19

12816054

-DNASE2chr19

12987177

-
In-frameENST00000356861ENST00000538460TNPO2chr19

12816053

-DNASE2chr19

12987177

-
In-frameENST00000425528ENST00000538460TNPO2chr19

12816054

-DNASE2chr19

12987177

-
In-frameENST00000425528ENST00000538460TNPO2chr19

12816053

-DNASE2chr19

12987177

-
In-frameENST00000441499ENST00000538460TNPO2chr19

12816054

-DNASE2chr19

12987177

-
In-frameENST00000441499ENST00000538460TNPO2chr19

12816053

-DNASE2chr19

12987177

-
In-frameENST00000450764ENST00000538460TNPO2chr19

12816054

-DNASE2chr19

12987177

-
In-frameENST00000450764ENST00000538460TNPO2chr19

12816053

-DNASE2chr19

12987177

-
In-frameENST00000588216ENST00000538460TNPO2chr19

12816054

-DNASE2chr19

12987177

-
In-frameENST00000588216ENST00000538460TNPO2chr19

12816053

-DNASE2chr19

12987177

-
In-frameENST00000592287ENST00000222219TNPO2chr19

12816054

-DNASE2chr19

12987177

-
In-frameENST00000592287ENST00000222219TNPO2chr19

12816053

-DNASE2chr19

12987177

-
intron-3CDSENST00000589956ENST00000222219TNPO2chr19

12816054

-DNASE2chr19

12987177

-
intron-3CDSENST00000589956ENST00000222219TNPO2chr19

12816053

-DNASE2chr19

12987177

-
intron-3CDSENST00000589956ENST00000538460TNPO2chr19

12816054

-DNASE2chr19

12987177

-
intron-3CDSENST00000589956ENST00000538460TNPO2chr19

12816053

-DNASE2chr19

12987177

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000425528TNPO2chr1912816054-ENST00000538460DNASE2chr1912987177-279923803162451711
ENST00000441499TNPO2chr1912816054-ENST00000538460DNASE2chr1912987177-279923803162451711
ENST00000356861TNPO2chr1912816054-ENST00000538460DNASE2chr1912987177-267622571992328709
ENST00000450764TNPO2chr1912816054-ENST00000538460DNASE2chr1912987177-317927603422831829
ENST00000592287TNPO2chr1912816054-ENST00000222219DNASE2chr1912987177-32842131492202717
ENST00000588216TNPO2chr1912816054-ENST00000538460DNASE2chr1912987177-281423953312466711
ENST00000425528TNPO2chr1912816053-ENST00000538460DNASE2chr1912987177-279923803162451711
ENST00000441499TNPO2chr1912816053-ENST00000538460DNASE2chr1912987177-279923803162451711
ENST00000356861TNPO2chr1912816053-ENST00000538460DNASE2chr1912987177-267622571992328709
ENST00000450764TNPO2chr1912816053-ENST00000538460DNASE2chr1912987177-317927603422831829
ENST00000592287TNPO2chr1912816053-ENST00000222219DNASE2chr1912987177-32842131492202717
ENST00000588216TNPO2chr1912816053-ENST00000538460DNASE2chr1912987177-281423953312466711

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000425528ENST00000538460TNPO2chr1912816054-DNASE2chr1912987177-0.0105365460.98946345
ENST00000441499ENST00000538460TNPO2chr1912816054-DNASE2chr1912987177-0.0105365460.98946345
ENST00000356861ENST00000538460TNPO2chr1912816054-DNASE2chr1912987177-0.0091519550.99084806
ENST00000450764ENST00000538460TNPO2chr1912816054-DNASE2chr1912987177-0.0150405310.9849594
ENST00000592287ENST00000222219TNPO2chr1912816054-DNASE2chr1912987177-0.0111233980.98887664
ENST00000588216ENST00000538460TNPO2chr1912816054-DNASE2chr1912987177-0.0108741050.98912597
ENST00000425528ENST00000538460TNPO2chr1912816053-DNASE2chr1912987177-0.0105365460.98946345
ENST00000441499ENST00000538460TNPO2chr1912816053-DNASE2chr1912987177-0.0105365460.98946345
ENST00000356861ENST00000538460TNPO2chr1912816053-DNASE2chr1912987177-0.0091519550.99084806
ENST00000450764ENST00000538460TNPO2chr1912816053-DNASE2chr1912987177-0.0150405310.9849594
ENST00000592287ENST00000222219TNPO2chr1912816053-DNASE2chr1912987177-0.0111233980.98887664
ENST00000588216ENST00000538460TNPO2chr1912816053-DNASE2chr1912987177-0.0108741050.98912597

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Fusion Genomic Features for TNPO2-DNASE2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TNPO2-DNASE2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:12816054/chr19:12987177)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DNASE2

O00115

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-172531_996741500.3333333333333DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-182631_996741509.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-182631_996741499.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-162431_996741150.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-182531_99674888.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-172531_99674901.6666666666666DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-172531_996741500.3333333333333DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-182631_996741509.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-182631_996741499.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-162431_996741150.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-182531_99674888.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-172531_99674901.6666666666666DomainNote=Importin N-terminal
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725127_1646741500.3333333333333RepeatHEAT 4
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725171_2016741500.3333333333333RepeatHEAT 5
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725214_2416741500.3333333333333RepeatHEAT 6
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725253_2806741500.3333333333333RepeatHEAT 7
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725296_3866741500.3333333333333RepeatHEAT 8
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725394_4226741500.3333333333333RepeatHEAT 9
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-172541_796741500.3333333333333RepeatHEAT 2
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725434_4616741500.3333333333333RepeatHEAT 10
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725475_5086741500.3333333333333RepeatHEAT 11
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725516_5496741500.3333333333333RepeatHEAT 12
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725557_5956741500.3333333333333RepeatHEAT 13
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725603_6546741500.3333333333333RepeatHEAT 14
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-172588_1216741500.3333333333333RepeatHEAT 3
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-17259_366741500.3333333333333RepeatHEAT 1
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826127_1646741509.0RepeatHEAT 4
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826171_2016741509.0RepeatHEAT 5
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826214_2416741509.0RepeatHEAT 6
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826253_2806741509.0RepeatHEAT 7
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826296_3866741509.0RepeatHEAT 8
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826394_4226741509.0RepeatHEAT 9
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-182641_796741509.0RepeatHEAT 2
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826434_4616741509.0RepeatHEAT 10
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826475_5086741509.0RepeatHEAT 11
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826516_5496741509.0RepeatHEAT 12
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826557_5956741509.0RepeatHEAT 13
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826603_6546741509.0RepeatHEAT 14
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-182688_1216741509.0RepeatHEAT 3
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-18269_366741509.0RepeatHEAT 1
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826127_1646741499.0RepeatHEAT 4
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826171_2016741499.0RepeatHEAT 5
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826214_2416741499.0RepeatHEAT 6
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826253_2806741499.0RepeatHEAT 7
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826296_3866741499.0RepeatHEAT 8
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826394_4226741499.0RepeatHEAT 9
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-182641_796741499.0RepeatHEAT 2
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826434_4616741499.0RepeatHEAT 10
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826475_5086741499.0RepeatHEAT 11
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826516_5496741499.0RepeatHEAT 12
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826557_5956741499.0RepeatHEAT 13
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826603_6546741499.0RepeatHEAT 14
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-182688_1216741499.0RepeatHEAT 3
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-18269_366741499.0RepeatHEAT 1
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624127_1646741150.0RepeatHEAT 4
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624171_2016741150.0RepeatHEAT 5
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624214_2416741150.0RepeatHEAT 6
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624253_2806741150.0RepeatHEAT 7
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624296_3866741150.0RepeatHEAT 8
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624394_4226741150.0RepeatHEAT 9
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-162441_796741150.0RepeatHEAT 2
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624434_4616741150.0RepeatHEAT 10
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624475_5086741150.0RepeatHEAT 11
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624516_5496741150.0RepeatHEAT 12
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624557_5956741150.0RepeatHEAT 13
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624603_6546741150.0RepeatHEAT 14
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-162488_1216741150.0RepeatHEAT 3
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-16249_366741150.0RepeatHEAT 1
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825127_164674888.0RepeatHEAT 4
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825171_201674888.0RepeatHEAT 5
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825214_241674888.0RepeatHEAT 6
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825253_280674888.0RepeatHEAT 7
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825296_386674888.0RepeatHEAT 8
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825394_422674888.0RepeatHEAT 9
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-182541_79674888.0RepeatHEAT 2
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825434_461674888.0RepeatHEAT 10
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825475_508674888.0RepeatHEAT 11
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825516_549674888.0RepeatHEAT 12
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825557_595674888.0RepeatHEAT 13
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825603_654674888.0RepeatHEAT 14
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-182588_121674888.0RepeatHEAT 3
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-18259_36674888.0RepeatHEAT 1
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725127_164674901.6666666666666RepeatHEAT 4
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725171_201674901.6666666666666RepeatHEAT 5
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725214_241674901.6666666666666RepeatHEAT 6
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725253_280674901.6666666666666RepeatHEAT 7
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725296_386674901.6666666666666RepeatHEAT 8
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725394_422674901.6666666666666RepeatHEAT 9
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-172541_79674901.6666666666666RepeatHEAT 2
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725434_461674901.6666666666666RepeatHEAT 10
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725475_508674901.6666666666666RepeatHEAT 11
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725516_549674901.6666666666666RepeatHEAT 12
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725557_595674901.6666666666666RepeatHEAT 13
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725603_654674901.6666666666666RepeatHEAT 14
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-172588_121674901.6666666666666RepeatHEAT 3
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-17259_36674901.6666666666666RepeatHEAT 1
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725127_1646741500.3333333333333RepeatHEAT 4
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725171_2016741500.3333333333333RepeatHEAT 5
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725214_2416741500.3333333333333RepeatHEAT 6
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725253_2806741500.3333333333333RepeatHEAT 7
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725296_3866741500.3333333333333RepeatHEAT 8
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725394_4226741500.3333333333333RepeatHEAT 9
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-172541_796741500.3333333333333RepeatHEAT 2
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725434_4616741500.3333333333333RepeatHEAT 10
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725475_5086741500.3333333333333RepeatHEAT 11
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725516_5496741500.3333333333333RepeatHEAT 12
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725557_5956741500.3333333333333RepeatHEAT 13
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725603_6546741500.3333333333333RepeatHEAT 14
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-172588_1216741500.3333333333333RepeatHEAT 3
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-17259_366741500.3333333333333RepeatHEAT 1
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826127_1646741509.0RepeatHEAT 4
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826171_2016741509.0RepeatHEAT 5
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826214_2416741509.0RepeatHEAT 6
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826253_2806741509.0RepeatHEAT 7
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826296_3866741509.0RepeatHEAT 8
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826394_4226741509.0RepeatHEAT 9
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-182641_796741509.0RepeatHEAT 2
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826434_4616741509.0RepeatHEAT 10
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826475_5086741509.0RepeatHEAT 11
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826516_5496741509.0RepeatHEAT 12
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826557_5956741509.0RepeatHEAT 13
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826603_6546741509.0RepeatHEAT 14
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-182688_1216741509.0RepeatHEAT 3
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-18269_366741509.0RepeatHEAT 1
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826127_1646741499.0RepeatHEAT 4
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826171_2016741499.0RepeatHEAT 5
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826214_2416741499.0RepeatHEAT 6
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826253_2806741499.0RepeatHEAT 7
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826296_3866741499.0RepeatHEAT 8
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826394_4226741499.0RepeatHEAT 9
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-182641_796741499.0RepeatHEAT 2
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826434_4616741499.0RepeatHEAT 10
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826475_5086741499.0RepeatHEAT 11
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826516_5496741499.0RepeatHEAT 12
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826557_5956741499.0RepeatHEAT 13
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826603_6546741499.0RepeatHEAT 14
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-182688_1216741499.0RepeatHEAT 3
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-18269_366741499.0RepeatHEAT 1
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624127_1646741150.0RepeatHEAT 4
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624171_2016741150.0RepeatHEAT 5
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624214_2416741150.0RepeatHEAT 6
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624253_2806741150.0RepeatHEAT 7
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624296_3866741150.0RepeatHEAT 8
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624394_4226741150.0RepeatHEAT 9
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-162441_796741150.0RepeatHEAT 2
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624434_4616741150.0RepeatHEAT 10
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624475_5086741150.0RepeatHEAT 11
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624516_5496741150.0RepeatHEAT 12
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624557_5956741150.0RepeatHEAT 13
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624603_6546741150.0RepeatHEAT 14
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-162488_1216741150.0RepeatHEAT 3
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-16249_366741150.0RepeatHEAT 1
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825127_164674888.0RepeatHEAT 4
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825171_201674888.0RepeatHEAT 5
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825214_241674888.0RepeatHEAT 6
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825253_280674888.0RepeatHEAT 7
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825296_386674888.0RepeatHEAT 8
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825394_422674888.0RepeatHEAT 9
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-182541_79674888.0RepeatHEAT 2
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825434_461674888.0RepeatHEAT 10
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825475_508674888.0RepeatHEAT 11
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825516_549674888.0RepeatHEAT 12
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825557_595674888.0RepeatHEAT 13
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825603_654674888.0RepeatHEAT 14
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-182588_121674888.0RepeatHEAT 3
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-18259_36674888.0RepeatHEAT 1
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725127_164674901.6666666666666RepeatHEAT 4
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725171_201674901.6666666666666RepeatHEAT 5
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725214_241674901.6666666666666RepeatHEAT 6
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725253_280674901.6666666666666RepeatHEAT 7
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725296_386674901.6666666666666RepeatHEAT 8
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725394_422674901.6666666666666RepeatHEAT 9
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-172541_79674901.6666666666666RepeatHEAT 2
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725434_461674901.6666666666666RepeatHEAT 10
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725475_508674901.6666666666666RepeatHEAT 11
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725516_549674901.6666666666666RepeatHEAT 12
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725557_595674901.6666666666666RepeatHEAT 13
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725603_654674901.6666666666666RepeatHEAT 14
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-172588_121674901.6666666666666RepeatHEAT 3
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-17259_36674901.6666666666666RepeatHEAT 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725665_6966741500.3333333333333RepeatHEAT 15
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725704_7376741500.3333333333333RepeatHEAT 16
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725745_7906741500.3333333333333RepeatHEAT 17
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725798_8316741500.3333333333333RepeatHEAT 18
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725840_8716741500.3333333333333RepeatHEAT 19
HgeneTNPO2chr19:12816053chr19:12987177ENST00000356861-1725874_8946741500.3333333333333RepeatHEAT 20
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826665_6966741509.0RepeatHEAT 15
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826704_7376741509.0RepeatHEAT 16
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826745_7906741509.0RepeatHEAT 17
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826798_8316741509.0RepeatHEAT 18
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826840_8716741509.0RepeatHEAT 19
HgeneTNPO2chr19:12816053chr19:12987177ENST00000425528-1826874_8946741509.0RepeatHEAT 20
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826665_6966741499.0RepeatHEAT 15
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826704_7376741499.0RepeatHEAT 16
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826745_7906741499.0RepeatHEAT 17
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826798_8316741499.0RepeatHEAT 18
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826840_8716741499.0RepeatHEAT 19
HgeneTNPO2chr19:12816053chr19:12987177ENST00000441499-1826874_8946741499.0RepeatHEAT 20
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624665_6966741150.0RepeatHEAT 15
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624704_7376741150.0RepeatHEAT 16
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624745_7906741150.0RepeatHEAT 17
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624798_8316741150.0RepeatHEAT 18
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624840_8716741150.0RepeatHEAT 19
HgeneTNPO2chr19:12816053chr19:12987177ENST00000450764-1624874_8946741150.0RepeatHEAT 20
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825665_696674888.0RepeatHEAT 15
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825704_737674888.0RepeatHEAT 16
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825745_790674888.0RepeatHEAT 17
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825798_831674888.0RepeatHEAT 18
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825840_871674888.0RepeatHEAT 19
HgeneTNPO2chr19:12816053chr19:12987177ENST00000588216-1825874_894674888.0RepeatHEAT 20
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725665_696674901.6666666666666RepeatHEAT 15
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725704_737674901.6666666666666RepeatHEAT 16
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725745_790674901.6666666666666RepeatHEAT 17
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725798_831674901.6666666666666RepeatHEAT 18
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725840_871674901.6666666666666RepeatHEAT 19
HgeneTNPO2chr19:12816053chr19:12987177ENST00000592287-1725874_894674901.6666666666666RepeatHEAT 20
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725665_6966741500.3333333333333RepeatHEAT 15
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725704_7376741500.3333333333333RepeatHEAT 16
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725745_7906741500.3333333333333RepeatHEAT 17
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725798_8316741500.3333333333333RepeatHEAT 18
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725840_8716741500.3333333333333RepeatHEAT 19
HgeneTNPO2chr19:12816054chr19:12987177ENST00000356861-1725874_8946741500.3333333333333RepeatHEAT 20
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826665_6966741509.0RepeatHEAT 15
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826704_7376741509.0RepeatHEAT 16
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826745_7906741509.0RepeatHEAT 17
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826798_8316741509.0RepeatHEAT 18
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826840_8716741509.0RepeatHEAT 19
HgeneTNPO2chr19:12816054chr19:12987177ENST00000425528-1826874_8946741509.0RepeatHEAT 20
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826665_6966741499.0RepeatHEAT 15
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826704_7376741499.0RepeatHEAT 16
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826745_7906741499.0RepeatHEAT 17
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826798_8316741499.0RepeatHEAT 18
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826840_8716741499.0RepeatHEAT 19
HgeneTNPO2chr19:12816054chr19:12987177ENST00000441499-1826874_8946741499.0RepeatHEAT 20
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624665_6966741150.0RepeatHEAT 15
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624704_7376741150.0RepeatHEAT 16
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624745_7906741150.0RepeatHEAT 17
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624798_8316741150.0RepeatHEAT 18
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624840_8716741150.0RepeatHEAT 19
HgeneTNPO2chr19:12816054chr19:12987177ENST00000450764-1624874_8946741150.0RepeatHEAT 20
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825665_696674888.0RepeatHEAT 15
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825704_737674888.0RepeatHEAT 16
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825745_790674888.0RepeatHEAT 17
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825798_831674888.0RepeatHEAT 18
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825840_871674888.0RepeatHEAT 19
HgeneTNPO2chr19:12816054chr19:12987177ENST00000588216-1825874_894674888.0RepeatHEAT 20
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725665_696674901.6666666666666RepeatHEAT 15
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725704_737674901.6666666666666RepeatHEAT 16
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725745_790674901.6666666666666RepeatHEAT 17
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725798_831674901.6666666666666RepeatHEAT 18
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725840_871674901.6666666666666RepeatHEAT 19
HgeneTNPO2chr19:12816054chr19:12987177ENST00000592287-1725874_894674901.6666666666666RepeatHEAT 20


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Fusion Gene Sequence for TNPO2-DNASE2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92795_92795_1_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000356861_DNASE2_chr19_12987177_ENST00000538460_length(transcript)=2676nt_BP=2257nt
GGGAAGCCGGTTGGGCCCGATCCTCCTGGCAGCTAGAACGGGCCGGGCGGGGGAGGGGGGAACCGAGCAGAGCTTAGGGGGTGGGGCCTC
GGAGCCAGGCCATGTCGGGGCTCCTCAAGAAGAGGGCCAGTGGGACTGCTGGGGTCGGGCTGGAGGGGATCTGATTGGGGGAAGCGTCTG
GGGACTGCTTGGGGCCTGATTGGGGGACGTCGCGAGGATCGGCTTGCCTTGCGCCATGGACTGGCAGCCAGACGAGCAGGGCCTGCAGCA
GGTCCTGCAGCTGCTCAAAGACTCACAGTCGCCCAACACAGCCACTCAGCGCATCGTGCAGGATAAACTCAAACAACTCAATCAGTTTCC
TGACTTCAACAACTACCTGATTTTCGTCCTGACCAGACTCAAGTCAGAAGATGAGCCAACGCGCTCTCTCAGTGGCCTCATCCTCAAGAA
CAACGTGAAGGCACACTATCAGAGCTTCCCACCCCCTGTGGCAGACTTCATCAAACAGGAGTGTCTCAACAACATTGGCGATGCCTCCTC
GCTCATCCGAGCCACCATTGGCATTCTCATCACCACCATCGCTTCCAAGGGTGAGCTGCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTG
CAACCTGCTTAACTCGGAGGATTACAACACTTGTGAGGGAGCCTTTGGAGCCCTGCAGAAGATCTGTGAAGACTCATCAGAGCTTCTGGA
CAGTGACGCCCTCAACAGGCCCCTCAACATCATGATCCCCAAGTTCCTGCAGTTCTTCAAGCACTGCAGTCCCAAGATCCGGTCCCACGC
CATCGCCTGCGTGAACCAGTTCATCATGGACCGGGCCCAGGCGCTGATGGACAATATTGACACCTTCATCGAGCACCTATTTGCCCTGGC
TGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTGCCGTGCCCTGGTGATGCTTCTGGAAGTGCGGATTGACAGGCTCATCCCCCACAT
GCACAGCATCATCCAGTACATGCTGCAGAGGACCCAGGACCATGATGAGAACGTTGCCCTTGAGGCCTGTGAGTTCTGGCTGACGCTGGC
CGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCATCTGGTCCAGTTGATCCCCATCTTGGTGAATGGGATGAAGTACTCGGAAATTGA
CATCATCCTGCTCAAGGGGGATGTGGAGGAGGATGAGGCTGTCCCCGACAGTGAGCAGGACATCAAGCCACGCTTCCACAAGTCACGCAC
GGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGGCTCCGAGGACGCGGAGGATGACGATGATGATGATGCTCTGTCCGACTGGAATTT
GAGGAAGTGCTCAGCGGCTGCACTGGACGTCCTCGCCAATGTCTTCCGGGAGGAACTGCTGCCCCACCTACTCCCACTACTCAAAGGCCT
CCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGGCATCCTGGTGCTGGGCGCCATTGCTGAGGGCTGCATGCAGGGCATGGTGCCCTA
CCTGCCTGAGCTGATCCCGCACCTGATCCAGTGCCTGTCGGATAAGAAGGCCTTGGTCCGCTCCATCGCCTGCTGGACGCTGAGCCGCTA
TGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCACCTCAAGCCCCTGATGACAGAGCTGCTCAAACGCATCCTGGATGGCAACAAGAG
GGTACAGGAGGCGGCCTGCAGTGCTTTTGCCACCCTGGAGGAAGAGGCCTGCACGGAGCTGGTGCCCTACCTCAGCTACATCCTGGACAC
CCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAACCTGCTCATCCTCTATGACGCCATTGGCACCCTGGCCGACTCTGTAGGCCACCA
CCTCAACCAGCCGGAATACATCCAGAAGCTGATGCCCCCACTGATCCAGAAGTGGAATGAGCTCAAGGACGAAGACAAGGACCTCTTCCC
CCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCTGCAGAGTGGCTTCCTGCCTTACTGTGAGCCCGTCTACCAGCGCTGTGTCACCCT
GGTGCAGAAGACACTGGCTCAGGCCATGATGTACACCCAGCACCCTGAGCAGTATGAGGCTCCCGACAAGGACTTCATGATCGTAGCACT
GGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGGTCACGTGGAGCAGCTGGTGGCCCGCAGCAACATCATGACATTGCTGTTCCAGTG
CATGCAGACCTGTACTCCGGCTGGTTGGCAGCAGCCCTTGGTACCAACCTGCAGGTCCAGTTCTGGCACAAAACTGTAGGCATCCTGCCC
TCTAACTGCTCGGATATCTGGCAGGTTCTGAATGTGAACCAGATAGCTTTCCCTGGACCAGCCGGCCCAAGCTTCAACAGCACAGAGGAC
CACTCCAAATGGTGCGTGTCCCCAAAAGGGCCCTGGACCTGCGTGGGTGACATGAATCGGAACCAGGGAGAGGAGCAACGGGGTGGGGGC
ACACTGTGTGCCCAGCTGCCAGCCCTCTGGAAAGCCTTCCAGCCGCTGGTGAAGAACTACCAGCCCTGTAATGGCATGGCCAGGAAGCCC

>92795_92795_1_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000356861_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=709AA_BP=685
MGDVARIGLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKAHY
QSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNR
PLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQY
MLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHE
AERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIP
HLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFG
KYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLA

--------------------------------------------------------------
>92795_92795_2_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000425528_DNASE2_chr19_12987177_ENST00000538460_length(transcript)=2799nt_BP=2380nt
AGAGGGAGGCCTTTACGCATGCCTTGGTGGCGGCTTTCTGCACGTGTTTCTCAGCCCAGGTTTCAGTCCAGCGGAACTGGCTACCTCGGA
ATCCCAACTGCTCCTTTAGGGTGTCTTCCGCGATTCTCCGAGTGGAGTTAGGCGCCTGCCGACACTTCCCTAACCTTGGAGGCCCGGGAC
TTGATTTTCATGAATGAACGGAGCCGGGACTGACTTTGCCTACGGCAAAGAAGGAAAAACGGTGCCCTACTGTCTTCAGACGTCGCAAGG
ATCAAGAAGATTTCTTTCTTCATGACCCTGCCCTTGCCAGAATTTCCTGCGCTGTTCCACCTCATTCAACTTCAGCTTGCCTTGCGCCAT
GGACTGGCAGCCAGACGAGCAGGGCCTGCAGCAGGTCCTGCAGCTGCTCAAAGACTCACAGTCGCCCAACACAGCCACTCAGCGCATCGT
GCAGGATAAACTCAAACAACTCAATCAGTTTCCTGACTTCAACAACTACCTGATTTTCGTCCTGACCAGACTCAAGTCAGAAGATGAGCC
AACGCGCTCTCTCAGTGGCCTCATCCTCAAGAACAACGTGAAGGCACACTATCAGAGCTTCCCACCCCCTGTGGCAGACTTCATCAAACA
GGAGTGTCTCAACAACATTGGCGATGCCTCCTCGCTCATCCGAGCCACCATTGGCATTCTCATCACCACCATCGCTTCCAAGGGTGAGCT
GCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTGCAACCTGCTTAACTCGGAGGATTACAACACTTGTGAGGGAGCCTTTGGAGCCCTGCA
GAAGATCTGTGAAGACTCATCAGAGCTTCTGGACAGTGACGCCCTCAACAGGCCCCTCAACATCATGATCCCCAAGTTCCTGCAGTTCTT
CAAGCACTGCAGTCCCAAGATCCGGTCCCACGCCATCGCCTGCGTGAACCAGTTCATCATGGACCGGGCCCAGGCGCTGATGGACAATAT
TGACACCTTCATCGAGCACCTATTTGCCCTGGCTGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTGCCGTGCCCTGGTGATGCTTCT
GGAAGTGCGGATTGACAGGCTCATCCCCCACATGCACAGCATCATCCAGTACATGCTGCAGAGGACCCAGGACCATGATGAGAACGTTGC
CCTTGAGGCCTGTGAGTTCTGGCTGACGCTGGCCGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCATCTGGTCCAGTTGATCCCCAT
CTTGGTGAATGGGATGAAGTACTCGGAAATTGACATCATCCTGCTCAAGGGGGATGTGGAGGAGGATGAGGCTGTCCCCGACAGTGAGCA
GGACATCAAGCCACGCTTCCACAAGTCACGCACGGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGGCTCCGAGGACGCGGAGGATGA
CGATGATGATGATGCTCTGTCCGACTGGAATTTGAGGAAGTGCTCAGCGGCTGCACTGGACGTCCTCGCCAATGTCTTCCGGGAGGAACT
GCTGCCCCACCTACTCCCACTACTCAAAGGCCTCCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGGCATCCTGGTGCTGGGCGCCAT
TGCTGAGGGCTGCATGCAGGGCATGGTGCCCTACCTGCCTGAGCTGATCCCGCACCTGATCCAGTGCCTGTCGGATAAGAAGGCCTTGGT
CCGCTCCATCGCCTGCTGGACGCTGAGCCGCTATGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCACCTCAAGCCCCTGATGACAGA
GCTGCTCAAACGCATCCTGGATGGCAACAAGAGGGTACAGGAGGCGGCCTGCAGTGCTTTTGCCACCCTGGAGGAAGAGGCCTGCACGGA
GCTGGTGCCCTACCTCAGCTACATCCTGGACACCCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAACCTGCTCATCCTCTATGACGC
CATTGGCACCCTGGCCGACTCTGTAGGCCACCACCTCAACCAGCCGGAATACATCCAGAAGCTGATGCCCCCACTGATCCAGAAGTGGAA
TGAGCTCAAGGACGAAGACAAGGACCTCTTCCCCCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCTGCAGAGTGGCTTCCTGCCTTA
CTGTGAGCCCGTCTACCAGCGCTGTGTCACCCTGGTGCAGAAGACACTGGCTCAGGCCATGATGTACACCCAGCACCCTGAGCAGTATGA
GGCTCCCGACAAGGACTTCATGATCGTAGCACTGGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGGTCACGTGGAGCAGCTGGTGGC
CCGCAGCAACATCATGACATTGCTGTTCCAGTGCATGCAGACCTGTACTCCGGCTGGTTGGCAGCAGCCCTTGGTACCAACCTGCAGGTC
CAGTTCTGGCACAAAACTGTAGGCATCCTGCCCTCTAACTGCTCGGATATCTGGCAGGTTCTGAATGTGAACCAGATAGCTTTCCCTGGA
CCAGCCGGCCCAAGCTTCAACAGCACAGAGGACCACTCCAAATGGTGCGTGTCCCCAAAAGGGCCCTGGACCTGCGTGGGTGACATGAAT
CGGAACCAGGGAGAGGAGCAACGGGGTGGGGGCACACTGTGTGCCCAGCTGCCAGCCCTCTGGAAAGCCTTCCAGCCGCTGGTGAAGAAC
TACCAGCCCTGTAATGGCATGGCCAGGAAGCCCAGCAGAGCTTATAAGATCTAACCCTTATGGCCAGGTGCAGTGGCTCACGTATGTAAT

>92795_92795_2_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000425528_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=711AA_BP=687
MRCSTSFNFSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKA
HYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDAL
NRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSII
QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLP
HEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPEL
IPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKT

--------------------------------------------------------------
>92795_92795_3_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000441499_DNASE2_chr19_12987177_ENST00000538460_length(transcript)=2799nt_BP=2380nt
AGAGGGAGGCCTTTACGCATGCCTTGGTGGCGGCTTTCTGCACGTGTTTCTCAGCCCAGGTTTCAGTCCAGCGGAACTGGCTACCTCGGA
ATCCCAACTGCTCCTTTAGGGTGTCTTCCGCGATTCTCCGAGTGGAGTTAGGCGCCTGCCGACACTTCCCTAACCTTGGAGGCCCGGGAC
TTGATTTTCATGAATGAACGGAGCCGGGACTGACTTTGCCTACGGCAAAGAAGGAAAAACGGTGCCCTACTGTCTTCAGACGTCGCAAGG
ATCAAGAAGATTTCTTTCTTCATGACCCTGCCCTTGCCAGAATTTCCTGCGCTGTTCCACCTCATTCAACTTCAGCTTGCCTTGCGCCAT
GGACTGGCAGCCAGACGAGCAGGGCCTGCAGCAGGTCCTGCAGCTGCTCAAAGACTCACAGTCGCCCAACACAGCCACTCAGCGCATCGT
GCAGGATAAACTCAAACAACTCAATCAGTTTCCTGACTTCAACAACTACCTGATTTTCGTCCTGACCAGACTCAAGTCAGAAGATGAGCC
AACGCGCTCTCTCAGTGGCCTCATCCTCAAGAACAACGTGAAGGCACACTATCAGAGCTTCCCACCCCCTGTGGCAGACTTCATCAAACA
GGAGTGTCTCAACAACATTGGCGATGCCTCCTCGCTCATCCGAGCCACCATTGGCATTCTCATCACCACCATCGCTTCCAAGGGTGAGCT
GCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTGCAACCTGCTTAACTCGGAGGATTACAACACTTGTGAGGGAGCCTTTGGAGCCCTGCA
GAAGATCTGTGAAGACTCATCAGAGCTTCTGGACAGTGACGCCCTCAACAGGCCCCTCAACATCATGATCCCCAAGTTCCTGCAGTTCTT
CAAGCACTGCAGTCCCAAGATCCGGTCCCACGCCATCGCCTGCGTGAACCAGTTCATCATGGACCGGGCCCAGGCGCTGATGGACAATAT
TGACACCTTCATCGAGCACCTATTTGCCCTGGCTGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTGCCGTGCCCTGGTGATGCTTCT
GGAAGTGCGGATTGACAGGCTCATCCCCCACATGCACAGCATCATCCAGTACATGCTGCAGAGGACCCAGGACCATGATGAGAACGTTGC
CCTTGAGGCCTGTGAGTTCTGGCTGACGCTGGCCGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCATCTGGTCCAGTTGATCCCCAT
CTTGGTGAATGGGATGAAGTACTCGGAAATTGACATCATCCTGCTCAAGGGGGATGTGGAGGAGGATGAGGCTGTCCCCGACAGTGAGCA
GGACATCAAGCCACGCTTCCACAAGTCACGCACGGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGGCTCCGAGGACGCGGAGGATGA
CGATGATGATGATGCTCTGTCCGACTGGAATTTGAGGAAGTGCTCAGCGGCTGCACTGGACGTCCTCGCCAATGTCTTCCGGGAGGAACT
GCTGCCCCACCTACTCCCACTACTCAAAGGCCTCCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGGCATCCTGGTGCTGGGCGCCAT
TGCTGAGGGCTGCATGCAGGGCATGGTGCCCTACCTGCCTGAGCTGATCCCGCACCTGATCCAGTGCCTGTCGGATAAGAAGGCCTTGGT
CCGCTCCATCGCCTGCTGGACGCTGAGCCGCTATGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCACCTCAAGCCCCTGATGACAGA
GCTGCTCAAACGCATCCTGGATGGCAACAAGAGGGTACAGGAGGCGGCCTGCAGTGCTTTTGCCACCCTGGAGGAAGAGGCCTGCACGGA
GCTGGTGCCCTACCTCAGCTACATCCTGGACACCCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAACCTGCTCATCCTCTATGACGC
CATTGGCACCCTGGCCGACTCTGTAGGCCACCACCTCAACCAGCCGGAATACATCCAGAAGCTGATGCCCCCACTGATCCAGAAGTGGAA
TGAGCTCAAGGACGAAGACAAGGACCTCTTCCCCCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCTGCAGAGTGGCTTCCTGCCTTA
CTGTGAGCCCGTCTACCAGCGCTGTGTCACCCTGGTGCAGAAGACACTGGCTCAGGCCATGATGTACACCCAGCACCCTGAGCAGTATGA
GGCTCCCGACAAGGACTTCATGATCGTAGCACTGGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGGTCACGTGGAGCAGCTGGTGGC
CCGCAGCAACATCATGACATTGCTGTTCCAGTGCATGCAGACCTGTACTCCGGCTGGTTGGCAGCAGCCCTTGGTACCAACCTGCAGGTC
CAGTTCTGGCACAAAACTGTAGGCATCCTGCCCTCTAACTGCTCGGATATCTGGCAGGTTCTGAATGTGAACCAGATAGCTTTCCCTGGA
CCAGCCGGCCCAAGCTTCAACAGCACAGAGGACCACTCCAAATGGTGCGTGTCCCCAAAAGGGCCCTGGACCTGCGTGGGTGACATGAAT
CGGAACCAGGGAGAGGAGCAACGGGGTGGGGGCACACTGTGTGCCCAGCTGCCAGCCCTCTGGAAAGCCTTCCAGCCGCTGGTGAAGAAC
TACCAGCCCTGTAATGGCATGGCCAGGAAGCCCAGCAGAGCTTATAAGATCTAACCCTTATGGCCAGGTGCAGTGGCTCACGTATGTAAT

>92795_92795_3_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000441499_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=711AA_BP=687
MRCSTSFNFSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKA
HYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDAL
NRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSII
QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLP
HEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPEL
IPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKT

--------------------------------------------------------------
>92795_92795_4_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000450764_DNASE2_chr19_12987177_ENST00000538460_length(transcript)=3179nt_BP=2760nt
GGCCGGGCTTGGCTGGCTCTCATTCGAAGAGGCAGCAGAGACCTACCTGGGGACTGCTTTGGGCCTGATTAAGGGGAATCCTTAGAATTT
GGCTAGGCCACAGAGGGGGATATCTGGCATCCACTGAGCTTGAAGGGCAGGAACAGGGGACAGGAGAGATCAGGACGATCGTCTTGGGAG
GGCGCATCTGGGGAAGCTCAGAAATTGGACTAGGGCAGGAGGCCTCTGGGATCTGGCAGAAGTTAAGGGCAGAGTGTCGGGGGAAGGGGA
CTCTTCAGGGACTGTGCCTGCATAGAAGAGACCACGGGGGCCGGGGCGCTATCACGGTCTGGGGCGGGGCCCCTGGATGTGGAGGCGGCT
GGGCCCTCGCCCAGCCGCTGCGAGGGAGGTGGAAGCCTTCGGGCTCGGAGCCGGGGTCAGCGGCATGGGCCACCCTGGGACGAGGGCTCT
TCGCTGGGTCCCATGAGGATCCGCCGGGCCCCGCCGCCGCCGCCTGTGGCCCGTTTCCACATCCCCCCTCCCGCGCTCCCGAGCCCGCGA
CTGCGCGGCCGAGGATGGCGCAGCTGGCGGGGACCCCGCACTTGGGCGGGCGTGGATCGGAGGCCTCCGCCTGTCCGCCGAGGGCGTTCC
CGTCGTCATGCGGCCACCGCGGCCTCAGGGGCTCCACCTGGGTCTCACACGGAGCCCCAGAGACCCAGCGCTGACCCCGGCCCCTACCTC
CGCAGCTTGCCTTGCGCCATGGACTGGCAGCCAGACGAGCAGGGCCTGCAGCAGGTCCTGCAGCTGCTCAAAGACTCACAGTCGCCCAAC
ACAGCCACTCAGCGCATCGTGCAGGATAAACTCAAACAACTCAATCAGTTTCCTGACTTCAACAACTACCTGATTTTCGTCCTGACCAGA
CTCAAGTCAGAAGATGAGCCAACGCGCTCTCTCAGTGGCCTCATCCTCAAGAACAACGTGAAGGCACACTATCAGAGCTTCCCACCCCCT
GTGGCAGACTTCATCAAACAGGAGTGTCTCAACAACATTGGCGATGCCTCCTCGCTCATCCGAGCCACCATTGGCATTCTCATCACCACC
ATCGCTTCCAAGGGTGAGCTGCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTGCAACCTGCTTAACTCGGAGGATTACAACACTTGTGAG
GGAGCCTTTGGAGCCCTGCAGAAGATCTGTGAAGACTCATCAGAGCTTCTGGACAGTGACGCCCTCAACAGGCCCCTCAACATCATGATC
CCCAAGTTCCTGCAGTTCTTCAAGCACTGCAGTCCCAAGATCCGGTCCCACGCCATCGCCTGCGTGAACCAGTTCATCATGGACCGGGCC
CAGGCGCTGATGGACAATATTGACACCTTCATCGAGCACCTATTTGCCCTGGCTGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTGC
CGTGCCCTGGTGATGCTTCTGGAAGTGCGGATTGACAGGCTCATCCCCCACATGCACAGCATCATCCAGTACATGCTGCAGAGGACCCAG
GACCATGATGAGAACGTTGCCCTTGAGGCCTGTGAGTTCTGGCTGACGCTGGCCGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCAT
CTGGTCCAGTTGATCCCCATCTTGGTGAATGGGATGAAGTACTCGGAAATTGACATCATCCTGCTCAAGGGGGATGTGGAGGAGGATGAG
GCTGTCCCCGACAGTGAGCAGGACATCAAGCCACGCTTCCACAAGTCACGCACGGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGGC
TCCGAGGACGCGGAGGATGACGATGATGATGATGCTCTGTCCGACTGGAATTTGAGGAAGTGCTCAGCGGCTGCACTGGACGTCCTCGCC
AATGTCTTCCGGGAGGAACTGCTGCCCCACCTACTCCCACTACTCAAAGGCCTCCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGGC
ATCCTGGTGCTGGGCGCCATTGCTGAGGGCTGCATGCAGGGCATGGTGCCCTACCTGCCTGAGCTGATCCCGCACCTGATCCAGTGCCTG
TCGGATAAGAAGGCCTTGGTCCGCTCCATCGCCTGCTGGACGCTGAGCCGCTATGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCAC
CTCAAGCCCCTGATGACAGAGCTGCTCAAACGCATCCTGGATGGCAACAAGAGGGTACAGGAGGCGGCCTGCAGTGCTTTTGCCACCCTG
GAGGAAGAGGCCTGCACGGAGCTGGTGCCCTACCTCAGCTACATCCTGGACACCCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAAC
CTGCTCATCCTCTATGACGCCATTGGCACCCTGGCCGACTCTGTAGGCCACCACCTCAACCAGCCGGAATACATCCAGAAGCTGATGCCC
CCACTGATCCAGAAGTGGAATGAGCTCAAGGACGAAGACAAGGACCTCTTCCCCCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCTG
CAGAGTGGCTTCCTGCCTTACTGTGAGCCCGTCTACCAGCGCTGTGTCACCCTGGTGCAGAAGACACTGGCTCAGGCCATGATGTACACC
CAGCACCCTGAGCAGTATGAGGCTCCCGACAAGGACTTCATGATCGTAGCACTGGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGGT
CACGTGGAGCAGCTGGTGGCCCGCAGCAACATCATGACATTGCTGTTCCAGTGCATGCAGACCTGTACTCCGGCTGGTTGGCAGCAGCCC
TTGGTACCAACCTGCAGGTCCAGTTCTGGCACAAAACTGTAGGCATCCTGCCCTCTAACTGCTCGGATATCTGGCAGGTTCTGAATGTGA
ACCAGATAGCTTTCCCTGGACCAGCCGGCCCAAGCTTCAACAGCACAGAGGACCACTCCAAATGGTGCGTGTCCCCAAAAGGGCCCTGGA
CCTGCGTGGGTGACATGAATCGGAACCAGGGAGAGGAGCAACGGGGTGGGGGCACACTGTGTGCCCAGCTGCCAGCCCTCTGGAAAGCCT
TCCAGCCGCTGGTGAAGAACTACCAGCCCTGTAATGGCATGGCCAGGAAGCCCAGCAGAGCTTATAAGATCTAACCCTTATGGCCAGGTG

>92795_92795_4_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000450764_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=829AA_BP=805
MDVEAAGPSPSRCEGGGSLRARSRGQRHGPPWDEGSSLGPMRIRRAPPPPPVARFHIPPPALPSPRLRGRGWRSWRGPRTWAGVDRRPPP
VRRGRSRRHAATAASGAPPGSHTEPQRPSADPGPYLRSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYL
IFVLTRLKSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSE
DYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPE
VRKNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKG
DVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEW
VVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAAC
SAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLS
SVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLLFQCMQTCTP

--------------------------------------------------------------
>92795_92795_5_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000588216_DNASE2_chr19_12987177_ENST00000538460_length(transcript)=2814nt_BP=2395nt
ATCGGAGGGTGGGGGAGAGGGAGGCCTTTACGCATGCCTTGGTGGCGGCTTTCTGCACGTGTTTCTCAGCCCAGGTTTCAGTCCAGCGGA
ACTGGCTACCTCGGAATCCCAACTGCTCCTTTAGGGTGTCTTCCGCGATTCTCCGAGTGGAGTTAGGCGCCTGCCGACACTTCCCTAACC
TTGGAGGCCCGGGACTTGATTTTCATGAATGAACGGAGCCGGGACTGACTTTGCCTACGGCAAAGAAGGAAAAACGGTGCCCTACTGTCT
TCAGACGTCGCAAGGATCAAGAAGATTTCTTTCTTCATGACCCTGCCCTTGCCAGAATTTCCTGCGCTGTTCCACCTCATTCAACTTCAG
CTTGCCTTGCGCCATGGACTGGCAGCCAGACGAGCAGGGCCTGCAGCAGGTCCTGCAGCTGCTCAAAGACTCACAGTCGCCCAACACAGC
CACTCAGCGCATCGTGCAGGATAAACTCAAACAACTCAATCAGTTTCCTGACTTCAACAACTACCTGATTTTCGTCCTGACCAGACTCAA
GTCAGAAGATGAGCCAACGCGCTCTCTCAGTGGCCTCATCCTCAAGAACAACGTGAAGGCACACTATCAGAGCTTCCCACCCCCTGTGGC
AGACTTCATCAAACAGGAGTGTCTCAACAACATTGGCGATGCCTCCTCGCTCATCCGAGCCACCATTGGCATTCTCATCACCACCATCGC
TTCCAAGGGTGAGCTGCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTGCAACCTGCTTAACTCGGAGGATTACAACACTTGTGAGGGAGC
CTTTGGAGCCCTGCAGAAGATCTGTGAAGACTCATCAGAGCTTCTGGACAGTGACGCCCTCAACAGGCCCCTCAACATCATGATCCCCAA
GTTCCTGCAGTTCTTCAAGCACTGCAGTCCCAAGATCCGGTCCCACGCCATCGCCTGCGTGAACCAGTTCATCATGGACCGGGCCCAGGC
GCTGATGGACAATATTGACACCTTCATCGAGCACCTATTTGCCCTGGCTGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTGCCGTGC
CCTGGTGATGCTTCTGGAAGTGCGGATTGACAGGCTCATCCCCCACATGCACAGCATCATCCAGTACATGCTGCAGAGGACCCAGGACCA
TGATGAGAACGTTGCCCTTGAGGCCTGTGAGTTCTGGCTGACGCTGGCCGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCATCTGGT
CCAGTTGATCCCCATCTTGGTGAATGGGATGAAGTACTCGGAAATTGACATCATCCTGCTCAAGGGGGATGTGGAGGAGGATGAGGCTGT
CCCCGACAGTGAGCAGGACATCAAGCCACGCTTCCACAAGTCACGCACGGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGGCTCCGA
GGACGCGGAGGATGACGATGATGATGATGCTCTGTCCGACTGGAATTTGAGGAAGTGCTCAGCGGCTGCACTGGACGTCCTCGCCAATGT
CTTCCGGGAGGAACTGCTGCCCCACCTACTCCCACTACTCAAAGGCCTCCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGGCATCCT
GGTGCTGGGCGCCATTGCTGAGGGCTGCATGCAGGGCATGGTGCCCTACCTGCCTGAGCTGATCCCGCACCTGATCCAGTGCCTGTCGGA
TAAGAAGGCCTTGGTCCGCTCCATCGCCTGCTGGACGCTGAGCCGCTATGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCACCTCAA
GCCCCTGATGACAGAGCTGCTCAAACGCATCCTGGATGGCAACAAGAGGGTACAGGAGGCGGCCTGCAGTGCTTTTGCCACCCTGGAGGA
AGAGGCCTGCACGGAGCTGGTGCCCTACCTCAGCTACATCCTGGACACCCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAACCTGCT
CATCCTCTATGACGCCATTGGCACCCTGGCCGACTCTGTAGGCCACCACCTCAACCAGCCGGAATACATCCAGAAGCTGATGCCCCCACT
GATCCAGAAGTGGAATGAGCTCAAGGACGAAGACAAGGACCTCTTCCCCCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCTGCAGAG
TGGCTTCCTGCCTTACTGTGAGCCCGTCTACCAGCGCTGTGTCACCCTGGTGCAGAAGACACTGGCTCAGGCCATGATGTACACCCAGCA
CCCTGAGCAGTATGAGGCTCCCGACAAGGACTTCATGATCGTAGCACTGGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGGTCACGT
GGAGCAGCTGGTGGCCCGCAGCAACATCATGACATTGCTGTTCCAGTGCATGCAGACCTGTACTCCGGCTGGTTGGCAGCAGCCCTTGGT
ACCAACCTGCAGGTCCAGTTCTGGCACAAAACTGTAGGCATCCTGCCCTCTAACTGCTCGGATATCTGGCAGGTTCTGAATGTGAACCAG
ATAGCTTTCCCTGGACCAGCCGGCCCAAGCTTCAACAGCACAGAGGACCACTCCAAATGGTGCGTGTCCCCAAAAGGGCCCTGGACCTGC
GTGGGTGACATGAATCGGAACCAGGGAGAGGAGCAACGGGGTGGGGGCACACTGTGTGCCCAGCTGCCAGCCCTCTGGAAAGCCTTCCAG
CCGCTGGTGAAGAACTACCAGCCCTGTAATGGCATGGCCAGGAAGCCCAGCAGAGCTTATAAGATCTAACCCTTATGGCCAGGTGCAGTG

>92795_92795_5_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000588216_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=711AA_BP=687
MRCSTSFNFSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKA
HYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDAL
NRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSII
QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLP
HEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPEL
IPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKT

--------------------------------------------------------------
>92795_92795_6_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000592287_DNASE2_chr19_12987177_ENST00000222219_length(transcript)=3284nt_BP=2131nt
TTTTTTTTTTTAATTCTCTCTCTTTGGCTCCCTCCTTCCGCGCGAGTCTCTGGAGAAGCCGCAGCGCGAGTTGCCGCCGCTGCTGCCCGG
GGCCGGCTTGCCTTGCGCCATGGACTGGCAGCCAGACGAGCAGGGCCTGCAGCAGGTCCTGCAGCTGCTCAAAGACTCACAGTCGCCCAA
CACAGCCACTCAGCGCATCGTGCAGGATAAACTCAAACAACTCAATCAGTTTCCTGACTTCAACAACTACCTGATTTTCGTCCTGACCAG
ACTCAAGTCAGAAGATGAGCCAACGCGCTCTCTCAGTGGCCTCATCCTCAAGAACAACGTGAAGGCACACTATCAGAGCTTCCCACCCCC
TGTGGCAGACTTCATCAAACAGGAGTGTCTCAACAACATTGGCGATGCCTCCTCGCTCATCCGAGCCACCATTGGCATTCTCATCACCAC
CATCGCTTCCAAGGGTGAGCTGCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTGCAACCTGCTTAACTCGGAGGATTACAACACTTGTGA
GGGAGCCTTTGGAGCCCTGCAGAAGATCTGTGAAGACTCATCAGAGCTTCTGGACAGTGACGCCCTCAACAGGCCCCTCAACATCATGAT
CCCCAAGTTCCTGCAGTTCTTCAAGCACTGCAGTCCCAAGATCCGGTCCCACGCCATCGCCTGCGTGAACCAGTTCATCATGGACCGGGC
CCAGGCGCTGATGGACAATATTGACACCTTCATCGAGCACCTATTTGCCCTGGCTGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTG
CCGTGCCCTGGTGATGCTTCTGGAAGTGCGGATTGACAGGCTCATCCCCCACATGCACAGCATCATCCAGTACATGCTGCAGAGGACCCA
GGACCATGATGAGAACGTTGCCCTTGAGGCCTGTGAGTTCTGGCTGACGCTGGCCGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCA
TCTGGTCCAGTTGATCCCCATCTTGGTGAATGGGATGAAGTACTCGGAAATTGACATCATCCTGCTCAAGGGGGATGTGGAGGAGGATGA
GGCTGTCCCCGACAGTGAGCAGGACATCAAGCCACGCTTCCACAAGTCACGCACGGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGG
CTCCGAGGACGCGGAGGATGACGATGATGATGATGCTCTGTCCGACTGGAATTTGAGGAAGTGCTCAGCGGCTGCACTGGACGTCCTCGC
CAATGTCTTCCGGGAGGAACTGCTGCCCCACCTACTCCCACTACTCAAAGGCCTCCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGG
CATCCTGGTGCTGGGCGCCATTGCTGAGGGCTGCATGCAGGGCATGGTGCCCTACCTGCCTGAGCTGATCCCGCACCTGATCCAGTGCCT
GTCGGATAAGAAGGCCTTGGTCCGCTCCATCGCCTGCTGGACGCTGAGCCGCTATGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCA
CCTCAAGCCCCTGATGACAGAGCTGCTCAAACGCATCCTGGATGGCAACAAGAGGGTACAGGAGGCGGCCTGCAGTGCTTTTGCCACCCT
GGAGGAAGAGGCCTGCACGGAGCTGGTGCCCTACCTCAGCTACATCCTGGACACCCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAA
CCTGCTCATCCTCTATGACGCCATTGGCACCCTGGCCGACTCTGTAGGCCACCACCTCAACCAGCCGGAATACATCCAGAAGCTGATGCC
CCCACTGATCCAGAAGTGGAATGAGCTCAAGGACGAAGACAAGGACCTCTTCCCCCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCT
GCAGAGTGGCTTCCTGCCTTACTGTGAGCCCGTCTACCAGCGCTGTGTCACCCTGGTGCAGAAGACACTGGCTCAGGCCATGATGTACAC
CCAGCACCCTGAGCAGTATGAGGCTCCCGACAAGGACTTCATGATCGTAGCACTGGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGG
TCACGTGGAGCAGCTGGTGGCCCGCAGCAACATCATGACATTGCTGTTCCAGTGCATGCAGACCTGTACTCCGGCTGGTTGGCAGCAGCC
CTTGGTACCAACCTGCAGGTCCAGTTCTGGCACAAAACTGTAGGCATCCTGCCCTCTAACTGCTCGGATATCTGGCAGGTTCTGAATGTG
AACCAGATAGCTTTCCCTGGACCAGCCGGCCCAAGCTTCAACAGCACAGAGGACCACTCCAAATGGTGCGTGTCCCCAAAAGGGCCCTGG
ACCTGCGTGGGTGACATGAATCGGAACCAGGGAGAGGAGCAACGGGGTGGGGGCACACTGTGTGCCCAGCTGCCAGCCCTCTGGAAAGCC
TTCCAGCCGCTGGTGAAGAACTACCAGCCCTGTAATGGCATGGCCAGGAAGCCCAGCAGAGCTTATAAGATCTAACCCTTATGGCCAGGT
GCAGTGGCTCACGTATGTAATCCCAGCACTTTGGGAAGCCAAGGAGGGAGGATCACTTGAACTCAGGAATTCGAGACCAGCCTGGGCTAC
ATAGTGAGACCACATCTCTACTAGAACTTAAAAAAAGTTAGCCAGGCACGGTGATAAATGCCTGTAGTCCCAGCCACTGAAGCCAGAGGA
TCGATTGAACCAGGGAGATCATGGTCACAGTGAACTATGATTACGCCAACCTGGGTCACATAGCAAGACTCTGTTTCAAAAAAAAAGGGG
GGGCGGGGGACGGGTGGGTGCAGTGGCTCACATCTGTAACCCCAGCACTTTGGGAGGCTGAGATGGGCAGATCACTTGAGGTCAGGAGTT
CGAGACCAGCCTGGCCAACATGGTGAAACCCCATATCCATTAAAAATATTTAAAAATTAGCCAGACATGGTGGCACGCGTCTGTGGTCCT
AGCTCCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACTCGGGAGGCAGAGGTTGTCATGAGCTGAGCTAACACCACGGCACTTCAGCCT
GGGTGACAGAATGAGACTCTGTGTCAAAAAAATAAAAAATAAAAAATCTAAGGGCTCAGGAACCAGTTTGGACTTGATTTTGAATCCCAG
TTCATCCCCTTCCTAGCTGTATGACCTTGATTGTGTGCCTTAACCGCTCTGTGACACAGTCTACCTGTCTGCAAAATGGGAAACATAATA

>92795_92795_6_TNPO2-DNASE2_TNPO2_chr19_12816053_ENST00000592287_DNASE2_chr19_12987177_ENST00000222219_length(amino acids)=717AA_BP=693
MEKPQRELPPLLPGAGLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLIL
KNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSEL
LDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIP
HMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKS
RTVTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMV
PYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYIL
DTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCV

--------------------------------------------------------------
>92795_92795_7_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000356861_DNASE2_chr19_12987177_ENST00000538460_length(transcript)=2676nt_BP=2257nt
GGGAAGCCGGTTGGGCCCGATCCTCCTGGCAGCTAGAACGGGCCGGGCGGGGGAGGGGGGAACCGAGCAGAGCTTAGGGGGTGGGGCCTC
GGAGCCAGGCCATGTCGGGGCTCCTCAAGAAGAGGGCCAGTGGGACTGCTGGGGTCGGGCTGGAGGGGATCTGATTGGGGGAAGCGTCTG
GGGACTGCTTGGGGCCTGATTGGGGGACGTCGCGAGGATCGGCTTGCCTTGCGCCATGGACTGGCAGCCAGACGAGCAGGGCCTGCAGCA
GGTCCTGCAGCTGCTCAAAGACTCACAGTCGCCCAACACAGCCACTCAGCGCATCGTGCAGGATAAACTCAAACAACTCAATCAGTTTCC
TGACTTCAACAACTACCTGATTTTCGTCCTGACCAGACTCAAGTCAGAAGATGAGCCAACGCGCTCTCTCAGTGGCCTCATCCTCAAGAA
CAACGTGAAGGCACACTATCAGAGCTTCCCACCCCCTGTGGCAGACTTCATCAAACAGGAGTGTCTCAACAACATTGGCGATGCCTCCTC
GCTCATCCGAGCCACCATTGGCATTCTCATCACCACCATCGCTTCCAAGGGTGAGCTGCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTG
CAACCTGCTTAACTCGGAGGATTACAACACTTGTGAGGGAGCCTTTGGAGCCCTGCAGAAGATCTGTGAAGACTCATCAGAGCTTCTGGA
CAGTGACGCCCTCAACAGGCCCCTCAACATCATGATCCCCAAGTTCCTGCAGTTCTTCAAGCACTGCAGTCCCAAGATCCGGTCCCACGC
CATCGCCTGCGTGAACCAGTTCATCATGGACCGGGCCCAGGCGCTGATGGACAATATTGACACCTTCATCGAGCACCTATTTGCCCTGGC
TGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTGCCGTGCCCTGGTGATGCTTCTGGAAGTGCGGATTGACAGGCTCATCCCCCACAT
GCACAGCATCATCCAGTACATGCTGCAGAGGACCCAGGACCATGATGAGAACGTTGCCCTTGAGGCCTGTGAGTTCTGGCTGACGCTGGC
CGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCATCTGGTCCAGTTGATCCCCATCTTGGTGAATGGGATGAAGTACTCGGAAATTGA
CATCATCCTGCTCAAGGGGGATGTGGAGGAGGATGAGGCTGTCCCCGACAGTGAGCAGGACATCAAGCCACGCTTCCACAAGTCACGCAC
GGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGGCTCCGAGGACGCGGAGGATGACGATGATGATGATGCTCTGTCCGACTGGAATTT
GAGGAAGTGCTCAGCGGCTGCACTGGACGTCCTCGCCAATGTCTTCCGGGAGGAACTGCTGCCCCACCTACTCCCACTACTCAAAGGCCT
CCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGGCATCCTGGTGCTGGGCGCCATTGCTGAGGGCTGCATGCAGGGCATGGTGCCCTA
CCTGCCTGAGCTGATCCCGCACCTGATCCAGTGCCTGTCGGATAAGAAGGCCTTGGTCCGCTCCATCGCCTGCTGGACGCTGAGCCGCTA
TGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCACCTCAAGCCCCTGATGACAGAGCTGCTCAAACGCATCCTGGATGGCAACAAGAG
GGTACAGGAGGCGGCCTGCAGTGCTTTTGCCACCCTGGAGGAAGAGGCCTGCACGGAGCTGGTGCCCTACCTCAGCTACATCCTGGACAC
CCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAACCTGCTCATCCTCTATGACGCCATTGGCACCCTGGCCGACTCTGTAGGCCACCA
CCTCAACCAGCCGGAATACATCCAGAAGCTGATGCCCCCACTGATCCAGAAGTGGAATGAGCTCAAGGACGAAGACAAGGACCTCTTCCC
CCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCTGCAGAGTGGCTTCCTGCCTTACTGTGAGCCCGTCTACCAGCGCTGTGTCACCCT
GGTGCAGAAGACACTGGCTCAGGCCATGATGTACACCCAGCACCCTGAGCAGTATGAGGCTCCCGACAAGGACTTCATGATCGTAGCACT
GGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGGTCACGTGGAGCAGCTGGTGGCCCGCAGCAACATCATGACATTGCTGTTCCAGTG
CATGCAGACCTGTACTCCGGCTGGTTGGCAGCAGCCCTTGGTACCAACCTGCAGGTCCAGTTCTGGCACAAAACTGTAGGCATCCTGCCC
TCTAACTGCTCGGATATCTGGCAGGTTCTGAATGTGAACCAGATAGCTTTCCCTGGACCAGCCGGCCCAAGCTTCAACAGCACAGAGGAC
CACTCCAAATGGTGCGTGTCCCCAAAAGGGCCCTGGACCTGCGTGGGTGACATGAATCGGAACCAGGGAGAGGAGCAACGGGGTGGGGGC
ACACTGTGTGCCCAGCTGCCAGCCCTCTGGAAAGCCTTCCAGCCGCTGGTGAAGAACTACCAGCCCTGTAATGGCATGGCCAGGAAGCCC

>92795_92795_7_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000356861_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=709AA_BP=685
MGDVARIGLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKAHY
QSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNR
PLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQY
MLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHE
AERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIP
HLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFG
KYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLA

--------------------------------------------------------------
>92795_92795_8_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000425528_DNASE2_chr19_12987177_ENST00000538460_length(transcript)=2799nt_BP=2380nt
AGAGGGAGGCCTTTACGCATGCCTTGGTGGCGGCTTTCTGCACGTGTTTCTCAGCCCAGGTTTCAGTCCAGCGGAACTGGCTACCTCGGA
ATCCCAACTGCTCCTTTAGGGTGTCTTCCGCGATTCTCCGAGTGGAGTTAGGCGCCTGCCGACACTTCCCTAACCTTGGAGGCCCGGGAC
TTGATTTTCATGAATGAACGGAGCCGGGACTGACTTTGCCTACGGCAAAGAAGGAAAAACGGTGCCCTACTGTCTTCAGACGTCGCAAGG
ATCAAGAAGATTTCTTTCTTCATGACCCTGCCCTTGCCAGAATTTCCTGCGCTGTTCCACCTCATTCAACTTCAGCTTGCCTTGCGCCAT
GGACTGGCAGCCAGACGAGCAGGGCCTGCAGCAGGTCCTGCAGCTGCTCAAAGACTCACAGTCGCCCAACACAGCCACTCAGCGCATCGT
GCAGGATAAACTCAAACAACTCAATCAGTTTCCTGACTTCAACAACTACCTGATTTTCGTCCTGACCAGACTCAAGTCAGAAGATGAGCC
AACGCGCTCTCTCAGTGGCCTCATCCTCAAGAACAACGTGAAGGCACACTATCAGAGCTTCCCACCCCCTGTGGCAGACTTCATCAAACA
GGAGTGTCTCAACAACATTGGCGATGCCTCCTCGCTCATCCGAGCCACCATTGGCATTCTCATCACCACCATCGCTTCCAAGGGTGAGCT
GCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTGCAACCTGCTTAACTCGGAGGATTACAACACTTGTGAGGGAGCCTTTGGAGCCCTGCA
GAAGATCTGTGAAGACTCATCAGAGCTTCTGGACAGTGACGCCCTCAACAGGCCCCTCAACATCATGATCCCCAAGTTCCTGCAGTTCTT
CAAGCACTGCAGTCCCAAGATCCGGTCCCACGCCATCGCCTGCGTGAACCAGTTCATCATGGACCGGGCCCAGGCGCTGATGGACAATAT
TGACACCTTCATCGAGCACCTATTTGCCCTGGCTGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTGCCGTGCCCTGGTGATGCTTCT
GGAAGTGCGGATTGACAGGCTCATCCCCCACATGCACAGCATCATCCAGTACATGCTGCAGAGGACCCAGGACCATGATGAGAACGTTGC
CCTTGAGGCCTGTGAGTTCTGGCTGACGCTGGCCGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCATCTGGTCCAGTTGATCCCCAT
CTTGGTGAATGGGATGAAGTACTCGGAAATTGACATCATCCTGCTCAAGGGGGATGTGGAGGAGGATGAGGCTGTCCCCGACAGTGAGCA
GGACATCAAGCCACGCTTCCACAAGTCACGCACGGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGGCTCCGAGGACGCGGAGGATGA
CGATGATGATGATGCTCTGTCCGACTGGAATTTGAGGAAGTGCTCAGCGGCTGCACTGGACGTCCTCGCCAATGTCTTCCGGGAGGAACT
GCTGCCCCACCTACTCCCACTACTCAAAGGCCTCCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGGCATCCTGGTGCTGGGCGCCAT
TGCTGAGGGCTGCATGCAGGGCATGGTGCCCTACCTGCCTGAGCTGATCCCGCACCTGATCCAGTGCCTGTCGGATAAGAAGGCCTTGGT
CCGCTCCATCGCCTGCTGGACGCTGAGCCGCTATGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCACCTCAAGCCCCTGATGACAGA
GCTGCTCAAACGCATCCTGGATGGCAACAAGAGGGTACAGGAGGCGGCCTGCAGTGCTTTTGCCACCCTGGAGGAAGAGGCCTGCACGGA
GCTGGTGCCCTACCTCAGCTACATCCTGGACACCCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAACCTGCTCATCCTCTATGACGC
CATTGGCACCCTGGCCGACTCTGTAGGCCACCACCTCAACCAGCCGGAATACATCCAGAAGCTGATGCCCCCACTGATCCAGAAGTGGAA
TGAGCTCAAGGACGAAGACAAGGACCTCTTCCCCCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCTGCAGAGTGGCTTCCTGCCTTA
CTGTGAGCCCGTCTACCAGCGCTGTGTCACCCTGGTGCAGAAGACACTGGCTCAGGCCATGATGTACACCCAGCACCCTGAGCAGTATGA
GGCTCCCGACAAGGACTTCATGATCGTAGCACTGGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGGTCACGTGGAGCAGCTGGTGGC
CCGCAGCAACATCATGACATTGCTGTTCCAGTGCATGCAGACCTGTACTCCGGCTGGTTGGCAGCAGCCCTTGGTACCAACCTGCAGGTC
CAGTTCTGGCACAAAACTGTAGGCATCCTGCCCTCTAACTGCTCGGATATCTGGCAGGTTCTGAATGTGAACCAGATAGCTTTCCCTGGA
CCAGCCGGCCCAAGCTTCAACAGCACAGAGGACCACTCCAAATGGTGCGTGTCCCCAAAAGGGCCCTGGACCTGCGTGGGTGACATGAAT
CGGAACCAGGGAGAGGAGCAACGGGGTGGGGGCACACTGTGTGCCCAGCTGCCAGCCCTCTGGAAAGCCTTCCAGCCGCTGGTGAAGAAC
TACCAGCCCTGTAATGGCATGGCCAGGAAGCCCAGCAGAGCTTATAAGATCTAACCCTTATGGCCAGGTGCAGTGGCTCACGTATGTAAT

>92795_92795_8_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000425528_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=711AA_BP=687
MRCSTSFNFSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKA
HYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDAL
NRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSII
QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLP
HEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPEL
IPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKT

--------------------------------------------------------------
>92795_92795_9_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000441499_DNASE2_chr19_12987177_ENST00000538460_length(transcript)=2799nt_BP=2380nt
AGAGGGAGGCCTTTACGCATGCCTTGGTGGCGGCTTTCTGCACGTGTTTCTCAGCCCAGGTTTCAGTCCAGCGGAACTGGCTACCTCGGA
ATCCCAACTGCTCCTTTAGGGTGTCTTCCGCGATTCTCCGAGTGGAGTTAGGCGCCTGCCGACACTTCCCTAACCTTGGAGGCCCGGGAC
TTGATTTTCATGAATGAACGGAGCCGGGACTGACTTTGCCTACGGCAAAGAAGGAAAAACGGTGCCCTACTGTCTTCAGACGTCGCAAGG
ATCAAGAAGATTTCTTTCTTCATGACCCTGCCCTTGCCAGAATTTCCTGCGCTGTTCCACCTCATTCAACTTCAGCTTGCCTTGCGCCAT
GGACTGGCAGCCAGACGAGCAGGGCCTGCAGCAGGTCCTGCAGCTGCTCAAAGACTCACAGTCGCCCAACACAGCCACTCAGCGCATCGT
GCAGGATAAACTCAAACAACTCAATCAGTTTCCTGACTTCAACAACTACCTGATTTTCGTCCTGACCAGACTCAAGTCAGAAGATGAGCC
AACGCGCTCTCTCAGTGGCCTCATCCTCAAGAACAACGTGAAGGCACACTATCAGAGCTTCCCACCCCCTGTGGCAGACTTCATCAAACA
GGAGTGTCTCAACAACATTGGCGATGCCTCCTCGCTCATCCGAGCCACCATTGGCATTCTCATCACCACCATCGCTTCCAAGGGTGAGCT
GCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTGCAACCTGCTTAACTCGGAGGATTACAACACTTGTGAGGGAGCCTTTGGAGCCCTGCA
GAAGATCTGTGAAGACTCATCAGAGCTTCTGGACAGTGACGCCCTCAACAGGCCCCTCAACATCATGATCCCCAAGTTCCTGCAGTTCTT
CAAGCACTGCAGTCCCAAGATCCGGTCCCACGCCATCGCCTGCGTGAACCAGTTCATCATGGACCGGGCCCAGGCGCTGATGGACAATAT
TGACACCTTCATCGAGCACCTATTTGCCCTGGCTGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTGCCGTGCCCTGGTGATGCTTCT
GGAAGTGCGGATTGACAGGCTCATCCCCCACATGCACAGCATCATCCAGTACATGCTGCAGAGGACCCAGGACCATGATGAGAACGTTGC
CCTTGAGGCCTGTGAGTTCTGGCTGACGCTGGCCGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCATCTGGTCCAGTTGATCCCCAT
CTTGGTGAATGGGATGAAGTACTCGGAAATTGACATCATCCTGCTCAAGGGGGATGTGGAGGAGGATGAGGCTGTCCCCGACAGTGAGCA
GGACATCAAGCCACGCTTCCACAAGTCACGCACGGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGGCTCCGAGGACGCGGAGGATGA
CGATGATGATGATGCTCTGTCCGACTGGAATTTGAGGAAGTGCTCAGCGGCTGCACTGGACGTCCTCGCCAATGTCTTCCGGGAGGAACT
GCTGCCCCACCTACTCCCACTACTCAAAGGCCTCCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGGCATCCTGGTGCTGGGCGCCAT
TGCTGAGGGCTGCATGCAGGGCATGGTGCCCTACCTGCCTGAGCTGATCCCGCACCTGATCCAGTGCCTGTCGGATAAGAAGGCCTTGGT
CCGCTCCATCGCCTGCTGGACGCTGAGCCGCTATGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCACCTCAAGCCCCTGATGACAGA
GCTGCTCAAACGCATCCTGGATGGCAACAAGAGGGTACAGGAGGCGGCCTGCAGTGCTTTTGCCACCCTGGAGGAAGAGGCCTGCACGGA
GCTGGTGCCCTACCTCAGCTACATCCTGGACACCCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAACCTGCTCATCCTCTATGACGC
CATTGGCACCCTGGCCGACTCTGTAGGCCACCACCTCAACCAGCCGGAATACATCCAGAAGCTGATGCCCCCACTGATCCAGAAGTGGAA
TGAGCTCAAGGACGAAGACAAGGACCTCTTCCCCCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCTGCAGAGTGGCTTCCTGCCTTA
CTGTGAGCCCGTCTACCAGCGCTGTGTCACCCTGGTGCAGAAGACACTGGCTCAGGCCATGATGTACACCCAGCACCCTGAGCAGTATGA
GGCTCCCGACAAGGACTTCATGATCGTAGCACTGGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGGTCACGTGGAGCAGCTGGTGGC
CCGCAGCAACATCATGACATTGCTGTTCCAGTGCATGCAGACCTGTACTCCGGCTGGTTGGCAGCAGCCCTTGGTACCAACCTGCAGGTC
CAGTTCTGGCACAAAACTGTAGGCATCCTGCCCTCTAACTGCTCGGATATCTGGCAGGTTCTGAATGTGAACCAGATAGCTTTCCCTGGA
CCAGCCGGCCCAAGCTTCAACAGCACAGAGGACCACTCCAAATGGTGCGTGTCCCCAAAAGGGCCCTGGACCTGCGTGGGTGACATGAAT
CGGAACCAGGGAGAGGAGCAACGGGGTGGGGGCACACTGTGTGCCCAGCTGCCAGCCCTCTGGAAAGCCTTCCAGCCGCTGGTGAAGAAC
TACCAGCCCTGTAATGGCATGGCCAGGAAGCCCAGCAGAGCTTATAAGATCTAACCCTTATGGCCAGGTGCAGTGGCTCACGTATGTAAT

>92795_92795_9_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000441499_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=711AA_BP=687
MRCSTSFNFSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKA
HYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDAL
NRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSII
QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLP
HEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPEL
IPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKT

--------------------------------------------------------------
>92795_92795_10_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000450764_DNASE2_chr19_12987177_ENST00000538460_length(transcript)=3179nt_BP=2760nt
GGCCGGGCTTGGCTGGCTCTCATTCGAAGAGGCAGCAGAGACCTACCTGGGGACTGCTTTGGGCCTGATTAAGGGGAATCCTTAGAATTT
GGCTAGGCCACAGAGGGGGATATCTGGCATCCACTGAGCTTGAAGGGCAGGAACAGGGGACAGGAGAGATCAGGACGATCGTCTTGGGAG
GGCGCATCTGGGGAAGCTCAGAAATTGGACTAGGGCAGGAGGCCTCTGGGATCTGGCAGAAGTTAAGGGCAGAGTGTCGGGGGAAGGGGA
CTCTTCAGGGACTGTGCCTGCATAGAAGAGACCACGGGGGCCGGGGCGCTATCACGGTCTGGGGCGGGGCCCCTGGATGTGGAGGCGGCT
GGGCCCTCGCCCAGCCGCTGCGAGGGAGGTGGAAGCCTTCGGGCTCGGAGCCGGGGTCAGCGGCATGGGCCACCCTGGGACGAGGGCTCT
TCGCTGGGTCCCATGAGGATCCGCCGGGCCCCGCCGCCGCCGCCTGTGGCCCGTTTCCACATCCCCCCTCCCGCGCTCCCGAGCCCGCGA
CTGCGCGGCCGAGGATGGCGCAGCTGGCGGGGACCCCGCACTTGGGCGGGCGTGGATCGGAGGCCTCCGCCTGTCCGCCGAGGGCGTTCC
CGTCGTCATGCGGCCACCGCGGCCTCAGGGGCTCCACCTGGGTCTCACACGGAGCCCCAGAGACCCAGCGCTGACCCCGGCCCCTACCTC
CGCAGCTTGCCTTGCGCCATGGACTGGCAGCCAGACGAGCAGGGCCTGCAGCAGGTCCTGCAGCTGCTCAAAGACTCACAGTCGCCCAAC
ACAGCCACTCAGCGCATCGTGCAGGATAAACTCAAACAACTCAATCAGTTTCCTGACTTCAACAACTACCTGATTTTCGTCCTGACCAGA
CTCAAGTCAGAAGATGAGCCAACGCGCTCTCTCAGTGGCCTCATCCTCAAGAACAACGTGAAGGCACACTATCAGAGCTTCCCACCCCCT
GTGGCAGACTTCATCAAACAGGAGTGTCTCAACAACATTGGCGATGCCTCCTCGCTCATCCGAGCCACCATTGGCATTCTCATCACCACC
ATCGCTTCCAAGGGTGAGCTGCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTGCAACCTGCTTAACTCGGAGGATTACAACACTTGTGAG
GGAGCCTTTGGAGCCCTGCAGAAGATCTGTGAAGACTCATCAGAGCTTCTGGACAGTGACGCCCTCAACAGGCCCCTCAACATCATGATC
CCCAAGTTCCTGCAGTTCTTCAAGCACTGCAGTCCCAAGATCCGGTCCCACGCCATCGCCTGCGTGAACCAGTTCATCATGGACCGGGCC
CAGGCGCTGATGGACAATATTGACACCTTCATCGAGCACCTATTTGCCCTGGCTGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTGC
CGTGCCCTGGTGATGCTTCTGGAAGTGCGGATTGACAGGCTCATCCCCCACATGCACAGCATCATCCAGTACATGCTGCAGAGGACCCAG
GACCATGATGAGAACGTTGCCCTTGAGGCCTGTGAGTTCTGGCTGACGCTGGCCGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCAT
CTGGTCCAGTTGATCCCCATCTTGGTGAATGGGATGAAGTACTCGGAAATTGACATCATCCTGCTCAAGGGGGATGTGGAGGAGGATGAG
GCTGTCCCCGACAGTGAGCAGGACATCAAGCCACGCTTCCACAAGTCACGCACGGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGGC
TCCGAGGACGCGGAGGATGACGATGATGATGATGCTCTGTCCGACTGGAATTTGAGGAAGTGCTCAGCGGCTGCACTGGACGTCCTCGCC
AATGTCTTCCGGGAGGAACTGCTGCCCCACCTACTCCCACTACTCAAAGGCCTCCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGGC
ATCCTGGTGCTGGGCGCCATTGCTGAGGGCTGCATGCAGGGCATGGTGCCCTACCTGCCTGAGCTGATCCCGCACCTGATCCAGTGCCTG
TCGGATAAGAAGGCCTTGGTCCGCTCCATCGCCTGCTGGACGCTGAGCCGCTATGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCAC
CTCAAGCCCCTGATGACAGAGCTGCTCAAACGCATCCTGGATGGCAACAAGAGGGTACAGGAGGCGGCCTGCAGTGCTTTTGCCACCCTG
GAGGAAGAGGCCTGCACGGAGCTGGTGCCCTACCTCAGCTACATCCTGGACACCCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAAC
CTGCTCATCCTCTATGACGCCATTGGCACCCTGGCCGACTCTGTAGGCCACCACCTCAACCAGCCGGAATACATCCAGAAGCTGATGCCC
CCACTGATCCAGAAGTGGAATGAGCTCAAGGACGAAGACAAGGACCTCTTCCCCCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCTG
CAGAGTGGCTTCCTGCCTTACTGTGAGCCCGTCTACCAGCGCTGTGTCACCCTGGTGCAGAAGACACTGGCTCAGGCCATGATGTACACC
CAGCACCCTGAGCAGTATGAGGCTCCCGACAAGGACTTCATGATCGTAGCACTGGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGGT
CACGTGGAGCAGCTGGTGGCCCGCAGCAACATCATGACATTGCTGTTCCAGTGCATGCAGACCTGTACTCCGGCTGGTTGGCAGCAGCCC
TTGGTACCAACCTGCAGGTCCAGTTCTGGCACAAAACTGTAGGCATCCTGCCCTCTAACTGCTCGGATATCTGGCAGGTTCTGAATGTGA
ACCAGATAGCTTTCCCTGGACCAGCCGGCCCAAGCTTCAACAGCACAGAGGACCACTCCAAATGGTGCGTGTCCCCAAAAGGGCCCTGGA
CCTGCGTGGGTGACATGAATCGGAACCAGGGAGAGGAGCAACGGGGTGGGGGCACACTGTGTGCCCAGCTGCCAGCCCTCTGGAAAGCCT
TCCAGCCGCTGGTGAAGAACTACCAGCCCTGTAATGGCATGGCCAGGAAGCCCAGCAGAGCTTATAAGATCTAACCCTTATGGCCAGGTG

>92795_92795_10_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000450764_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=829AA_BP=805
MDVEAAGPSPSRCEGGGSLRARSRGQRHGPPWDEGSSLGPMRIRRAPPPPPVARFHIPPPALPSPRLRGRGWRSWRGPRTWAGVDRRPPP
VRRGRSRRHAATAASGAPPGSHTEPQRPSADPGPYLRSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYL
IFVLTRLKSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSE
DYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPE
VRKNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKG
DVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEW
VVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAAC
SAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLS
SVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLLFQCMQTCTP

--------------------------------------------------------------
>92795_92795_11_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000588216_DNASE2_chr19_12987177_ENST00000538460_length(transcript)=2814nt_BP=2395nt
ATCGGAGGGTGGGGGAGAGGGAGGCCTTTACGCATGCCTTGGTGGCGGCTTTCTGCACGTGTTTCTCAGCCCAGGTTTCAGTCCAGCGGA
ACTGGCTACCTCGGAATCCCAACTGCTCCTTTAGGGTGTCTTCCGCGATTCTCCGAGTGGAGTTAGGCGCCTGCCGACACTTCCCTAACC
TTGGAGGCCCGGGACTTGATTTTCATGAATGAACGGAGCCGGGACTGACTTTGCCTACGGCAAAGAAGGAAAAACGGTGCCCTACTGTCT
TCAGACGTCGCAAGGATCAAGAAGATTTCTTTCTTCATGACCCTGCCCTTGCCAGAATTTCCTGCGCTGTTCCACCTCATTCAACTTCAG
CTTGCCTTGCGCCATGGACTGGCAGCCAGACGAGCAGGGCCTGCAGCAGGTCCTGCAGCTGCTCAAAGACTCACAGTCGCCCAACACAGC
CACTCAGCGCATCGTGCAGGATAAACTCAAACAACTCAATCAGTTTCCTGACTTCAACAACTACCTGATTTTCGTCCTGACCAGACTCAA
GTCAGAAGATGAGCCAACGCGCTCTCTCAGTGGCCTCATCCTCAAGAACAACGTGAAGGCACACTATCAGAGCTTCCCACCCCCTGTGGC
AGACTTCATCAAACAGGAGTGTCTCAACAACATTGGCGATGCCTCCTCGCTCATCCGAGCCACCATTGGCATTCTCATCACCACCATCGC
TTCCAAGGGTGAGCTGCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTGCAACCTGCTTAACTCGGAGGATTACAACACTTGTGAGGGAGC
CTTTGGAGCCCTGCAGAAGATCTGTGAAGACTCATCAGAGCTTCTGGACAGTGACGCCCTCAACAGGCCCCTCAACATCATGATCCCCAA
GTTCCTGCAGTTCTTCAAGCACTGCAGTCCCAAGATCCGGTCCCACGCCATCGCCTGCGTGAACCAGTTCATCATGGACCGGGCCCAGGC
GCTGATGGACAATATTGACACCTTCATCGAGCACCTATTTGCCCTGGCTGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTGCCGTGC
CCTGGTGATGCTTCTGGAAGTGCGGATTGACAGGCTCATCCCCCACATGCACAGCATCATCCAGTACATGCTGCAGAGGACCCAGGACCA
TGATGAGAACGTTGCCCTTGAGGCCTGTGAGTTCTGGCTGACGCTGGCCGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCATCTGGT
CCAGTTGATCCCCATCTTGGTGAATGGGATGAAGTACTCGGAAATTGACATCATCCTGCTCAAGGGGGATGTGGAGGAGGATGAGGCTGT
CCCCGACAGTGAGCAGGACATCAAGCCACGCTTCCACAAGTCACGCACGGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGGCTCCGA
GGACGCGGAGGATGACGATGATGATGATGCTCTGTCCGACTGGAATTTGAGGAAGTGCTCAGCGGCTGCACTGGACGTCCTCGCCAATGT
CTTCCGGGAGGAACTGCTGCCCCACCTACTCCCACTACTCAAAGGCCTCCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGGCATCCT
GGTGCTGGGCGCCATTGCTGAGGGCTGCATGCAGGGCATGGTGCCCTACCTGCCTGAGCTGATCCCGCACCTGATCCAGTGCCTGTCGGA
TAAGAAGGCCTTGGTCCGCTCCATCGCCTGCTGGACGCTGAGCCGCTATGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCACCTCAA
GCCCCTGATGACAGAGCTGCTCAAACGCATCCTGGATGGCAACAAGAGGGTACAGGAGGCGGCCTGCAGTGCTTTTGCCACCCTGGAGGA
AGAGGCCTGCACGGAGCTGGTGCCCTACCTCAGCTACATCCTGGACACCCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAACCTGCT
CATCCTCTATGACGCCATTGGCACCCTGGCCGACTCTGTAGGCCACCACCTCAACCAGCCGGAATACATCCAGAAGCTGATGCCCCCACT
GATCCAGAAGTGGAATGAGCTCAAGGACGAAGACAAGGACCTCTTCCCCCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCTGCAGAG
TGGCTTCCTGCCTTACTGTGAGCCCGTCTACCAGCGCTGTGTCACCCTGGTGCAGAAGACACTGGCTCAGGCCATGATGTACACCCAGCA
CCCTGAGCAGTATGAGGCTCCCGACAAGGACTTCATGATCGTAGCACTGGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGGTCACGT
GGAGCAGCTGGTGGCCCGCAGCAACATCATGACATTGCTGTTCCAGTGCATGCAGACCTGTACTCCGGCTGGTTGGCAGCAGCCCTTGGT
ACCAACCTGCAGGTCCAGTTCTGGCACAAAACTGTAGGCATCCTGCCCTCTAACTGCTCGGATATCTGGCAGGTTCTGAATGTGAACCAG
ATAGCTTTCCCTGGACCAGCCGGCCCAAGCTTCAACAGCACAGAGGACCACTCCAAATGGTGCGTGTCCCCAAAAGGGCCCTGGACCTGC
GTGGGTGACATGAATCGGAACCAGGGAGAGGAGCAACGGGGTGGGGGCACACTGTGTGCCCAGCTGCCAGCCCTCTGGAAAGCCTTCCAG
CCGCTGGTGAAGAACTACCAGCCCTGTAATGGCATGGCCAGGAAGCCCAGCAGAGCTTATAAGATCTAACCCTTATGGCCAGGTGCAGTG

>92795_92795_11_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000588216_DNASE2_chr19_12987177_ENST00000538460_length(amino acids)=711AA_BP=687
MRCSTSFNFSLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKA
HYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDAL
NRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSII
QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLP
HEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPEL
IPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFA
FGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKT

--------------------------------------------------------------
>92795_92795_12_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000592287_DNASE2_chr19_12987177_ENST00000222219_length(transcript)=3284nt_BP=2131nt
TTTTTTTTTTTAATTCTCTCTCTTTGGCTCCCTCCTTCCGCGCGAGTCTCTGGAGAAGCCGCAGCGCGAGTTGCCGCCGCTGCTGCCCGG
GGCCGGCTTGCCTTGCGCCATGGACTGGCAGCCAGACGAGCAGGGCCTGCAGCAGGTCCTGCAGCTGCTCAAAGACTCACAGTCGCCCAA
CACAGCCACTCAGCGCATCGTGCAGGATAAACTCAAACAACTCAATCAGTTTCCTGACTTCAACAACTACCTGATTTTCGTCCTGACCAG
ACTCAAGTCAGAAGATGAGCCAACGCGCTCTCTCAGTGGCCTCATCCTCAAGAACAACGTGAAGGCACACTATCAGAGCTTCCCACCCCC
TGTGGCAGACTTCATCAAACAGGAGTGTCTCAACAACATTGGCGATGCCTCCTCGCTCATCCGAGCCACCATTGGCATTCTCATCACCAC
CATCGCTTCCAAGGGTGAGCTGCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTGCAACCTGCTTAACTCGGAGGATTACAACACTTGTGA
GGGAGCCTTTGGAGCCCTGCAGAAGATCTGTGAAGACTCATCAGAGCTTCTGGACAGTGACGCCCTCAACAGGCCCCTCAACATCATGAT
CCCCAAGTTCCTGCAGTTCTTCAAGCACTGCAGTCCCAAGATCCGGTCCCACGCCATCGCCTGCGTGAACCAGTTCATCATGGACCGGGC
CCAGGCGCTGATGGACAATATTGACACCTTCATCGAGCACCTATTTGCCCTGGCTGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTG
CCGTGCCCTGGTGATGCTTCTGGAAGTGCGGATTGACAGGCTCATCCCCCACATGCACAGCATCATCCAGTACATGCTGCAGAGGACCCA
GGACCATGATGAGAACGTTGCCCTTGAGGCCTGTGAGTTCTGGCTGACGCTGGCCGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCA
TCTGGTCCAGTTGATCCCCATCTTGGTGAATGGGATGAAGTACTCGGAAATTGACATCATCCTGCTCAAGGGGGATGTGGAGGAGGATGA
GGCTGTCCCCGACAGTGAGCAGGACATCAAGCCACGCTTCCACAAGTCACGCACGGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGG
CTCCGAGGACGCGGAGGATGACGATGATGATGATGCTCTGTCCGACTGGAATTTGAGGAAGTGCTCAGCGGCTGCACTGGACGTCCTCGC
CAATGTCTTCCGGGAGGAACTGCTGCCCCACCTACTCCCACTACTCAAAGGCCTCCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGG
CATCCTGGTGCTGGGCGCCATTGCTGAGGGCTGCATGCAGGGCATGGTGCCCTACCTGCCTGAGCTGATCCCGCACCTGATCCAGTGCCT
GTCGGATAAGAAGGCCTTGGTCCGCTCCATCGCCTGCTGGACGCTGAGCCGCTATGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCA
CCTCAAGCCCCTGATGACAGAGCTGCTCAAACGCATCCTGGATGGCAACAAGAGGGTACAGGAGGCGGCCTGCAGTGCTTTTGCCACCCT
GGAGGAAGAGGCCTGCACGGAGCTGGTGCCCTACCTCAGCTACATCCTGGACACCCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAA
CCTGCTCATCCTCTATGACGCCATTGGCACCCTGGCCGACTCTGTAGGCCACCACCTCAACCAGCCGGAATACATCCAGAAGCTGATGCC
CCCACTGATCCAGAAGTGGAATGAGCTCAAGGACGAAGACAAGGACCTCTTCCCCCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCT
GCAGAGTGGCTTCCTGCCTTACTGTGAGCCCGTCTACCAGCGCTGTGTCACCCTGGTGCAGAAGACACTGGCTCAGGCCATGATGTACAC
CCAGCACCCTGAGCAGTATGAGGCTCCCGACAAGGACTTCATGATCGTAGCACTGGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGG
TCACGTGGAGCAGCTGGTGGCCCGCAGCAACATCATGACATTGCTGTTCCAGTGCATGCAGACCTGTACTCCGGCTGGTTGGCAGCAGCC
CTTGGTACCAACCTGCAGGTCCAGTTCTGGCACAAAACTGTAGGCATCCTGCCCTCTAACTGCTCGGATATCTGGCAGGTTCTGAATGTG
AACCAGATAGCTTTCCCTGGACCAGCCGGCCCAAGCTTCAACAGCACAGAGGACCACTCCAAATGGTGCGTGTCCCCAAAAGGGCCCTGG
ACCTGCGTGGGTGACATGAATCGGAACCAGGGAGAGGAGCAACGGGGTGGGGGCACACTGTGTGCCCAGCTGCCAGCCCTCTGGAAAGCC
TTCCAGCCGCTGGTGAAGAACTACCAGCCCTGTAATGGCATGGCCAGGAAGCCCAGCAGAGCTTATAAGATCTAACCCTTATGGCCAGGT
GCAGTGGCTCACGTATGTAATCCCAGCACTTTGGGAAGCCAAGGAGGGAGGATCACTTGAACTCAGGAATTCGAGACCAGCCTGGGCTAC
ATAGTGAGACCACATCTCTACTAGAACTTAAAAAAAGTTAGCCAGGCACGGTGATAAATGCCTGTAGTCCCAGCCACTGAAGCCAGAGGA
TCGATTGAACCAGGGAGATCATGGTCACAGTGAACTATGATTACGCCAACCTGGGTCACATAGCAAGACTCTGTTTCAAAAAAAAAGGGG
GGGCGGGGGACGGGTGGGTGCAGTGGCTCACATCTGTAACCCCAGCACTTTGGGAGGCTGAGATGGGCAGATCACTTGAGGTCAGGAGTT
CGAGACCAGCCTGGCCAACATGGTGAAACCCCATATCCATTAAAAATATTTAAAAATTAGCCAGACATGGTGGCACGCGTCTGTGGTCCT
AGCTCCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACTCGGGAGGCAGAGGTTGTCATGAGCTGAGCTAACACCACGGCACTTCAGCCT
GGGTGACAGAATGAGACTCTGTGTCAAAAAAATAAAAAATAAAAAATCTAAGGGCTCAGGAACCAGTTTGGACTTGATTTTGAATCCCAG
TTCATCCCCTTCCTAGCTGTATGACCTTGATTGTGTGCCTTAACCGCTCTGTGACACAGTCTACCTGTCTGCAAAATGGGAAACATAATA

>92795_92795_12_TNPO2-DNASE2_TNPO2_chr19_12816054_ENST00000592287_DNASE2_chr19_12987177_ENST00000222219_length(amino acids)=717AA_BP=693
MEKPQRELPPLLPGAGLPCAMDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLIL
KNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSEL
LDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIP
HMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKS
RTVTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMV
PYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYIL
DTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TNPO2-DNASE2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TNPO2-DNASE2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TNPO2-DNASE2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource