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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TNRC6A-PRKCB (FusionGDB2 ID:92855)

Fusion Gene Summary for TNRC6A-PRKCB

check button Fusion gene summary
Fusion gene informationFusion gene name: TNRC6A-PRKCB
Fusion gene ID: 92855
HgeneTgene
Gene symbol

TNRC6A

PRKCB

Gene ID

27327

5579

Gene nametrinucleotide repeat containing adaptor 6Aprotein kinase C beta
SynonymsCAGH26|FAME6|GW1|GW182|TNRC6PKC-beta|PKCB|PKCI(2)|PKCbeta|PRKCB1|PRKCB2
Cytomap

16p12.1

16p12.2-p12.1

Type of geneprotein-codingprotein-coding
Descriptiontrinucleotide repeat-containing gene 6A proteinCAG repeat protein 26CTD-2540M10.1EDIEEMSY interactor proteinGW182 autoantigenglycine-tryptophan protein of 182 kDatrinucleotide repeat containing 6Aprotein kinase C beta typePKC-Bprotein kinase C, beta 1 polypeptide
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000562829, ENST00000315183, 
ENST00000395799, ENST00000432286, 
ENST00000303531, ENST00000321728, 
ENST00000482000, ENST00000498058, 
Fusion gene scores* DoF score10 X 10 X 6=60020 X 15 X 13=3900
# samples 1225
** MAII scorelog2(12/600*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/3900*10)=-3.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNRC6A [Title/Abstract] AND PRKCB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTNRC6A(24741621)-PRKCB(24192111), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNRC6A

GO:0035278

miRNA mediated inhibition of translation

17671087

TgenePRKCB

GO:0010827

regulation of glucose transmembrane transport

25982116

TgenePRKCB

GO:0035408

histone H3-T6 phosphorylation

20228790


check buttonFusion gene breakpoints across TNRC6A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRKCB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0882-01ATNRC6Achr16

24741621

-PRKCBchr16

24192111

+
ChimerDB4GBMTCGA-06-0882-01ATNRC6Achr16

24741621

+PRKCBchr16

24192111

+


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Fusion Gene ORF analysis for TNRC6A-PRKCB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000562829ENST00000303531TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
3UTR-3CDSENST00000562829ENST00000321728TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
3UTR-intronENST00000562829ENST00000482000TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
3UTR-intronENST00000562829ENST00000498058TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
5CDS-intronENST00000315183ENST00000482000TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
5CDS-intronENST00000315183ENST00000498058TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
5CDS-intronENST00000395799ENST00000482000TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
5CDS-intronENST00000395799ENST00000498058TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
In-frameENST00000315183ENST00000303531TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
In-frameENST00000315183ENST00000321728TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
In-frameENST00000395799ENST00000303531TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
In-frameENST00000395799ENST00000321728TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
intron-3CDSENST00000432286ENST00000303531TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
intron-3CDSENST00000432286ENST00000321728TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
intron-intronENST00000432286ENST00000482000TNRC6Achr16

24741621

+PRKCBchr16

24192111

+
intron-intronENST00000432286ENST00000498058TNRC6Achr16

24741621

+PRKCBchr16

24192111

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000315183TNRC6Achr1624741621+ENST00000321728PRKCBchr1624192111+1320200126821231
ENST00000315183TNRC6Achr1624741621+ENST00000303531PRKCBchr1624192111+6623200126827233
ENST00000395799TNRC6Achr1624741621+ENST00000321728PRKCBchr1624192111+1302182108803231
ENST00000395799TNRC6Achr1624741621+ENST00000303531PRKCBchr1624192111+6605182108809233

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000315183ENST00000321728TNRC6Achr1624741621+PRKCBchr1624192111+0.0009795940.99902046
ENST00000315183ENST00000303531TNRC6Achr1624741621+PRKCBchr1624192111+0.001207670.9987923
ENST00000395799ENST00000321728TNRC6Achr1624741621+PRKCBchr1624192111+0.0012490720.9987509
ENST00000395799ENST00000303531TNRC6Achr1624741621+PRKCBchr1624192111+0.0012271960.9987728

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Fusion Genomic Features for TNRC6A-PRKCB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TNRC6Achr1624741621+PRKCBchr1624192110+6.38E-060.99999356
TNRC6Achr1624741621+PRKCBchr1624192110+6.38E-060.99999356

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TNRC6A-PRKCB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:24741621/chr16:24192111)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePRKCBchr16:24741621chr16:24192111ENST000003035311117601_671464674.0DomainAGC-kinase C-terminal
TgenePRKCBchr16:24741621chr16:24192111ENST000003217281117601_671464672.0DomainAGC-kinase C-terminal
TgenePRKCBchr16:24741621chr16:24192111ENST0000049805802158_275058.0DomainC2
TgenePRKCBchr16:24741621chr16:24192111ENST0000049805802342_600058.0DomainProtein kinase
TgenePRKCBchr16:24741621chr16:24192111ENST0000049805802601_671058.0DomainAGC-kinase C-terminal
TgenePRKCBchr16:24741621chr16:24192111ENST0000049805802348_356058.0Nucleotide bindingATP
TgenePRKCBchr16:24741621chr16:24192111ENST0000049805802101_151058.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCBchr16:24741621chr16:24192111ENST000004980580236_86058.0Zinc fingerPhorbol-ester/DAG-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNRC6Achr16:24741621chr16:24192111ENST00000315183+2247_54171914.0Coiled coilOntology_term=ECO:0000255
HgeneTNRC6Achr16:24741621chr16:24192111ENST00000395799+2257_54171963.0Coiled coilOntology_term=ECO:0000255
HgeneTNRC6Achr16:24741621chr16:24192111ENST00000315183+224192_365171914.0Compositional biasNote=Ser-rich
HgeneTNRC6Achr16:24741621chr16:24192111ENST00000315183+22493_127171914.0Compositional biasNote=Gln-rich
HgeneTNRC6Achr16:24741621chr16:24192111ENST00000395799+225192_365171963.0Compositional biasNote=Ser-rich
HgeneTNRC6Achr16:24741621chr16:24192111ENST00000395799+22593_127171963.0Compositional biasNote=Gln-rich
HgeneTNRC6Achr16:24741621chr16:24192111ENST00000315183+2241781_1853171914.0DomainNote=RRM
HgeneTNRC6Achr16:24741621chr16:24192111ENST00000395799+2251781_1853171963.0DomainNote=RRM
HgeneTNRC6Achr16:24741621chr16:24192111ENST00000315183+2241604_1622171914.0RegionNote=PABPC1-interacting motif-2 (PAM2)
HgeneTNRC6Achr16:24741621chr16:24192111ENST00000395799+2251604_1622171963.0RegionNote=PABPC1-interacting motif-2 (PAM2)
TgenePRKCBchr16:24741621chr16:24192111ENST000003035311117158_275464674.0DomainC2
TgenePRKCBchr16:24741621chr16:24192111ENST000003035311117342_600464674.0DomainProtein kinase
TgenePRKCBchr16:24741621chr16:24192111ENST000003217281117158_275464672.0DomainC2
TgenePRKCBchr16:24741621chr16:24192111ENST000003217281117342_600464672.0DomainProtein kinase
TgenePRKCBchr16:24741621chr16:24192111ENST000003035311117348_356464674.0Nucleotide bindingATP
TgenePRKCBchr16:24741621chr16:24192111ENST000003217281117348_356464672.0Nucleotide bindingATP
TgenePRKCBchr16:24741621chr16:24192111ENST000003035311117101_151464674.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCBchr16:24741621chr16:24192111ENST00000303531111736_86464674.0Zinc fingerPhorbol-ester/DAG-type 1
TgenePRKCBchr16:24741621chr16:24192111ENST000003217281117101_151464672.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCBchr16:24741621chr16:24192111ENST00000321728111736_86464672.0Zinc fingerPhorbol-ester/DAG-type 1


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Fusion Gene Sequence for TNRC6A-PRKCB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92855_92855_1_TNRC6A-PRKCB_TNRC6A_chr16_24741621_ENST00000315183_PRKCB_chr16_24192111_ENST00000303531_length(transcript)=6623nt_BP=200nt
GGCGGCGGCGGCGGCGGCGGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGG
GCTTGAGGCTCGCGAGCCTCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGAC
GTAGAAAGAAATCTTAGCAGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTGCCGATTTTGGCATGTGT
AAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTAT
GGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAA
CTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAA
CACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATATTGATTGGGAGAAACTT
GAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTTGTGGGCGAAATGCTGAAAACTTCGACCGATTTTTCACCCGCCATCCACCA
GTCCTAACACCTCCCGACCAGGAAGTCATCAGGAATATTGACCAATCAGAATTCGAAGGATTTTCCTTTGTTAACTCTGAATTTTTAAAA
CCCGAAGTCAAGAGCTAAGTAGATGTGTAGATCTCCGTCCTTCATTTCTGTCATTCAAGCTCAACGGCTATTGTGGTGACATTTTTATGT
TTTTCATTGCCAAGTTGCATCCATGTTTGATTTTCTGATGAGACTAGAGTGACAGTGTTTCAGAACCCAAATGTCCTCAGGTAGTTTGGA
GCATCTCTATGAGATGGGATTATGCAGATGGCCTATGGAAAATGCAGCTGCATAATTAACACATTATCAAAGTCCTCTTACAATTTATTT
TCCGCAGCATGTCAGCTAAGTAGACCCAATGGGGAGAGAAAATGCCTGCTTTCTTTCCCTCTTTTTCTGCACTGCCATATTCACCCCCAA
CCATCCAATCTGTGGATAATTGGATGTTAGCGGTACTCTTCCACTTCCGGGCCTGGAGCTTGGCTTGTATCCAAGTGTATGGTTGCTTTG
CCTAAGAGGAATCCCTCTATTTCACCTGTTCTGGAGGCACCAGACCTTGAAAAGAACATGCTCAAAATAAAATGTTATCTGTTATTTTTG
TAAACTCAAAGTTAAGATGATCAAAGTTCTAAAATTCCAAGAATGTGCTTTTAGACGGTCTCAATCTAAAAGCACTTCAAGGGGTCAAAG
GGCAACCAGCTTGGGTGCTACCTCAGTGTTGTAGTTTCTGATACTTTATGTCTTTGCTCACCCTCATCCCCAAACTACTTGAAAAGGGCA
TTTGGCACCACTCTCTGAAACAACACAGTCACTCTAGCAAGGCCCCCAAAGGGCCCTGGTTTTACATTACATTTCAAACTTTATTTGCTT
TGGGGTTTTGTTTCTGTTGTTGTTCAAATGCAAAAAAAAGAAAAAAAAAGAAAAAAAAAGGTGACTCACATTGTTACACATGCTTTAAAA
TATGTATTCAAATGTTATTAACCACAATGACGACCTGCTTTGATTTAACCAAGAAGACGGCTGCGGAGCCTAGCAGACTCAGGCCTGTGG
GAATGGGATTTGTTACAAATCTAGGTTTGTTACTGGCTTCAGAAAGCTAATTAAGTGCTCTGAAAAAGACACCGTTTCTTGAAACAAAGA
TGGTTGTATTCCTCACTTTGATGTTGTTTTGCAAGATGTTTGTGGAAATGTTCATTTGTATCTGGATCTCTGTTATGTGCCATTTTTCTT
CTAGCATCGAGATACAATAAAAAAAAAAAAAAAGAAAAGAAGAAGAAATACTATTTCAAGGAAAACTGCTCTTTTTGAGAAACGTGGACC
TAAACTACAAAGTGGGAACTGAGGAGGGAACTCAGGAGAAAGGAACTAACTGCGGAGCTTTAATCTTGGCCCCAGTGTTCAGCCACTCGG
AGGGGCGGGGGCTGTGGCCCATTCAGGGGCTGCTGGTGGGCTGTAGTGGGGTGGGATGACCTGGCCAGAGCCAACGAGGATACTGGAGCC
CAAAGTCAAGTTTAGAGACCAGCTGGGAACGTGAATGGGGCTCTTGATTTTCTTATCAAAATCACCACTCCTCCCAGCTTGGACTAAATA
TTCTTTCTAGCAAGCAGCTTTGTGAGCTCCCTGAAGCCCAAGGAAACCCTTCGGTGGGAGAAATTTCATTTCTGTCTGAGAGGATTAAGG
CAGCAGGTGACTCCCCCTCCTCGCCTGCCGTGTCCTGCTATTCTCAGGCAGCTCTAAGGAGAATTCTTATCACAGTTCAAGTGATTTCCA
GAAGTTCCAGGGCTTCTGAGAGACCATCAAGGGAACTTTAACAACTTGACAAATGTCCTTGAAGTAAGATGCCTCATCTTTAGGGAAAAA
TGGGGTTTGGATTTCTGCTTAGGCAAAGTCTCCTGCAGTTCATCCTTCTCTGTCCTCTTCTTGCTTCAGGCTTGGGGACCGTCCCTGCTG
TCCCCACTGTGGTGGCAATCAGGACCTAAGGTGAAGCAAACTTGAAGTTCTATCTGACAAGTTTAGGCAGTAAGAGAAGGAGGGAAATCG
GAGCAAAGCTCCCTCACTTTATTGTTGAGAAACTGGCATCTGGAAAGAGGAAGGAATTTGCCCAAAGTCAGTCAGCTGGGATAAAAACCT
GGGTGTCCTGTCCAGAAAGTGCAGGGTGCTTTCTGCTCTGTAGCAAGGCAGCAGACATCTCTGAGCCAGGCCCACCAACAGGCCCTTATC
TGGTGGTTGGATCATGATCCCATTTTGCTTGGACATGCTCTCAGGAAGATAAAAACCATGGAGAAACACTAGGCCATTGACAAATGATCT
GAGACAACTTTAGAAAACAATGTAGGATGAATGGAAAGAGAAAGAAAGGAAAGAAAGAAGAAAAAGAAAGAAGGAAAGAAAGAAAGAGAA
AGGAAGGAAGGAAAGAAGGAAGGAAAAGAAGGAAGGAAGGAAGGAATATAGTGTTATAAATACTGCACTCAACATTTTCCAAATTCTTGC
CATTATTTTTCAAAAGTTTAATAGTTTGCAGAAATAGATACTCAAGCCAAAGTCTGTTTTAGAGAAACTTTCCATGGAAAGTCAGAATTT
CTACCACTTCCTTTTCTATCCACATTTCCAGTGCAGAAGAAACTGAGAAACAGAGCTTTTTGAAGAGAGGACAGGGCCATAGCAACAAGG
ACCTTCTTGGGGGATTAATGGGAGGTCAGTAGAATTAATAACCCTCCTTGGATGAGTGCTACTGTTTTCACATGGCTTCAGATGCTATCA
ACCTCAAAGAAATGATCTCAACAGAGAAGCTTATTCTCTCCCAACTTCTACGGTAAAATCCAGGAGTATTTTCTCTGGGGATCTGCCCAC
AGGACAAAGTCCATAAAAGCAAGTCCTGTCTGGACCATGTGGTTATCTGAAGCATTAGCCATCACCAGCACAACAAACGGGGCAGGGCTT
TCCAAGGTGGGGCTGGTCAGAAGGGAATCTTTGATAAGAGGCCCACAGGCAGGGAAAGCGAAATAGGGTTGATGAGACCAGGGGAGACCT
AAAAAAAAGGCAGCTTTGTGTCTTCTAGCTCCAAATATACCTGCCTTTTAGCTCACACACTGTCCTGGAGTTCTCAGACCTTTAGGGGCC
CTAACACAGTTCAGTTCATACAGGGGTTCAAAAGGGACAGTGGCCCATTTGGGAGACCTTTAGGATCAATGGGAATCAATTCCATTGTTT
TGCCTCAGAGTAAAGTTTCTGGCTCGGGGACAATTATAAGTTGCAAAAAGGATAGAGGCATATCCCAAGTCTTCCTTCATTCCACAAATA
ATTACAAACAACCTACTGTGTGCCAGGCACTATTCTTAGCACTGGAAATACACTAGTGAAGAAGCAGATGAGGACCCTGTTTATTGTTTC
TCTCCAAGAAATTCTCCAAGAATATTGTTTCTTGGAGAGAAATAATAAATAAACAAGACAATTTCTGAAAGCAATAAGTGCAATCAAGAT
AATTAAAGGATGCTAAAGTGTGACTTGTGGGGATTGGGAGAGAGATGCACAGACAATATTAAAGAGGAGGCATTCGAGCTTTGTTGTGAA
CACCGGAAGTAACATGCCGAGCGCCTGGGGGATGGAAACTCCTATAGCACCCCACAGGCTAACAGCAAGCAGGACAAGACAAAAAGGGCA
GGTGGGACATGGTAGAGATGGACCCTACCCAGGAAACAGCTCCATCAGCATCTTAGCCTGCCCCACTCTAGCCACACATACCCACGTGTG
CTCCTGAGTTCAGTGTGCCCACCTCACTCCCACACCCTCACATAGACTTGGCAAGAGTAAGGAGGGAACTCCATAGAGACATTTTACCTA
TCTCAGGGGAGCAGCCACAAAGAAGCAAGTCTTGTAAAAGGTCTTTTGCAAAGGAGAGTGAACCCAGCAATGAGAGATCCTTAACAGCTA
GTGCCCATTAGGGGGCTAAACCTAAAGCCTGGGTGGTGATGGCTCAAACGCTAATGAGTCAGTGAATCCTTACCGACCCCCTGGCCTTTA
TAATCTGAGGCAACTTTGGCTGCAGCCCGGGAATGTGCAGGGCACTAGGGAATACAAGGCCTTCTTCCCTGGTTGTCTTGTAATAAAACA
GCCATGGGGTTGTCCCTCCAGTCCGAGAGACTGTGATGAGGCCTACATAGCAGCGATGTGGTCAGGTAAAAATCAGGAACCCACTGAAAT
CTTGGGCAAGCCACCCTGCCTGCTTGTGCCTCGGTTCTCTCATATGTCATATATAGGAGGTGAGGACTCCAGCTCCACCTGCCCCAGGTG
GGTGTGGTGATGATGAGGAAAGACAAGAGGCTTGCAAGGACCCTGAAGAGGTCGGAGCATCATACAGATTCCTTTATTAGCCCACATTCT
GATGTTCCCTGGTGAGACTTGCCCCAAGCAATTGCTAGTAAATGGGGGTTAATTTCTTCTCCACCTCCCTACTGAACAAAAAAAGAAATG
CCAGACTTACTAGGAGAATCGAGTTGCTTTGAGTTTCTTTTGTTTTGTTTTGTTTTGTTTTGTTTTAAGGCTCCCCTTACACACCCTCCT
TTAAGCTTTGGGTTTTCTCTCTTATAGTTTGTTGACACATGCTAAAAATGTCTTTGGAGAGAACTTCTGCCTGATAAACACCCAATTCTA
GACTGTGGGTGGATTTTCGAGCTGACGGTGGTCAATTCCTTTCATTAAGCAGTGATCTGATTTCTCCACATGGCCATTCTGCCTTCTTGG
GGGCAGAGTAGATGGGCAGCAGTTCACCTTTTCAGAGAAAGAGGTCTTCTAGCCACCTGGGCTGCTACTGAATGGTTTTCTCCAGGACGC
TCTACCTAATGATTATTTCTATAACATTAAGCATGGTAATAAGTAGCTTCCAATTCAATTCATCCTAAAGCCAAAGAAAATACAGCAACA
CACACACACACACACACACACACACACACACACACACACACACACCACTTTATGGCAATTCTTAACTGACATTCAATGACTTACTTCTTT
TCTTAGAAAATTTCCACCACATTTCTATCCCCAAGCCAACATACAATGTGAAATGAAAGCCAGTGCGTGGAGTGCAGCTGCTAAAAATTT
TCAGCACAGGGCTCTTTCTGACTCTGCTCATGAGATGGTATCAGCCACCCAATGACTGGCGTATCTTGGTCCTGTGTCTTTCTTCTTACG
CTGTGTTAATGTGTTTACTTTCCATTTGGCAGAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAAC
TGACCCCCACTGATAAACTCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTCATTAATG
TGTAGGTGAATGCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGATTCACGG
TGCACATGCTGGCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAA
AATGTTTAGTTTAGAATAAGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAAATGAACAGACAATGTCA
AAACTACTGTGTCTGATACCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATT
CTATAATATCTTCTTTGAATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGTCTCTTGG

>92855_92855_1_TNRC6A-PRKCB_TNRC6A_chr16_24741621_ENST00000315183_PRKCB_chr16_24192111_ENST00000303531_length(amino acids)=233AA_BP=24
MLVHFTHMRELEAKATKDVERNLSSDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL
LYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK

--------------------------------------------------------------
>92855_92855_2_TNRC6A-PRKCB_TNRC6A_chr16_24741621_ENST00000315183_PRKCB_chr16_24192111_ENST00000321728_length(transcript)=1320nt_BP=200nt
GGCGGCGGCGGCGGCGGCGGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGG
GCTTGAGGCTCGCGAGCCTCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGAC
GTAGAAAGAAATCTTAGCAGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTGCCGATTTTGGCATGTGT
AAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTAT
GGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAA
CTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAA
CACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATATTGATTGGGAGAAACTT
GAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCT
GTGGAACTGACCCCCACTGATAAACTCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTC
ATTAATGTGTAGGTGAATGCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGA
TTCACGGTGCACATGCTGGCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTAC
ATTTGAAAATGTTTAGTTTAGAATAAGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAAATGAACAGAC
AATGTCAAAACTACTGTGTCTGATACCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTAC
AGTTATTCTATAATATCTTCTTTGAATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGT

>92855_92855_2_TNRC6A-PRKCB_TNRC6A_chr16_24741621_ENST00000315183_PRKCB_chr16_24192111_ENST00000321728_length(amino acids)=231AA_BP=24
MLVHFTHMRELEAKATKDVERNLSSDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL
LYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK

--------------------------------------------------------------
>92855_92855_3_TNRC6A-PRKCB_TNRC6A_chr16_24741621_ENST00000395799_PRKCB_chr16_24192111_ENST00000303531_length(transcript)=6605nt_BP=182nt
GGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGGGCTTGAGGCTCGCGAGCC
TCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGC
AGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGAT
GGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGG
TGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATG
GAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTG
GGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAG
CCCCCTTATAAGCCAAAAGCTTGTGGGCGAAATGCTGAAAACTTCGACCGATTTTTCACCCGCCATCCACCAGTCCTAACACCTCCCGAC
CAGGAAGTCATCAGGAATATTGACCAATCAGAATTCGAAGGATTTTCCTTTGTTAACTCTGAATTTTTAAAACCCGAAGTCAAGAGCTAA
GTAGATGTGTAGATCTCCGTCCTTCATTTCTGTCATTCAAGCTCAACGGCTATTGTGGTGACATTTTTATGTTTTTCATTGCCAAGTTGC
ATCCATGTTTGATTTTCTGATGAGACTAGAGTGACAGTGTTTCAGAACCCAAATGTCCTCAGGTAGTTTGGAGCATCTCTATGAGATGGG
ATTATGCAGATGGCCTATGGAAAATGCAGCTGCATAATTAACACATTATCAAAGTCCTCTTACAATTTATTTTCCGCAGCATGTCAGCTA
AGTAGACCCAATGGGGAGAGAAAATGCCTGCTTTCTTTCCCTCTTTTTCTGCACTGCCATATTCACCCCCAACCATCCAATCTGTGGATA
ATTGGATGTTAGCGGTACTCTTCCACTTCCGGGCCTGGAGCTTGGCTTGTATCCAAGTGTATGGTTGCTTTGCCTAAGAGGAATCCCTCT
ATTTCACCTGTTCTGGAGGCACCAGACCTTGAAAAGAACATGCTCAAAATAAAATGTTATCTGTTATTTTTGTAAACTCAAAGTTAAGAT
GATCAAAGTTCTAAAATTCCAAGAATGTGCTTTTAGACGGTCTCAATCTAAAAGCACTTCAAGGGGTCAAAGGGCAACCAGCTTGGGTGC
TACCTCAGTGTTGTAGTTTCTGATACTTTATGTCTTTGCTCACCCTCATCCCCAAACTACTTGAAAAGGGCATTTGGCACCACTCTCTGA
AACAACACAGTCACTCTAGCAAGGCCCCCAAAGGGCCCTGGTTTTACATTACATTTCAAACTTTATTTGCTTTGGGGTTTTGTTTCTGTT
GTTGTTCAAATGCAAAAAAAAGAAAAAAAAAGAAAAAAAAAGGTGACTCACATTGTTACACATGCTTTAAAATATGTATTCAAATGTTAT
TAACCACAATGACGACCTGCTTTGATTTAACCAAGAAGACGGCTGCGGAGCCTAGCAGACTCAGGCCTGTGGGAATGGGATTTGTTACAA
ATCTAGGTTTGTTACTGGCTTCAGAAAGCTAATTAAGTGCTCTGAAAAAGACACCGTTTCTTGAAACAAAGATGGTTGTATTCCTCACTT
TGATGTTGTTTTGCAAGATGTTTGTGGAAATGTTCATTTGTATCTGGATCTCTGTTATGTGCCATTTTTCTTCTAGCATCGAGATACAAT
AAAAAAAAAAAAAAAGAAAAGAAGAAGAAATACTATTTCAAGGAAAACTGCTCTTTTTGAGAAACGTGGACCTAAACTACAAAGTGGGAA
CTGAGGAGGGAACTCAGGAGAAAGGAACTAACTGCGGAGCTTTAATCTTGGCCCCAGTGTTCAGCCACTCGGAGGGGCGGGGGCTGTGGC
CCATTCAGGGGCTGCTGGTGGGCTGTAGTGGGGTGGGATGACCTGGCCAGAGCCAACGAGGATACTGGAGCCCAAAGTCAAGTTTAGAGA
CCAGCTGGGAACGTGAATGGGGCTCTTGATTTTCTTATCAAAATCACCACTCCTCCCAGCTTGGACTAAATATTCTTTCTAGCAAGCAGC
TTTGTGAGCTCCCTGAAGCCCAAGGAAACCCTTCGGTGGGAGAAATTTCATTTCTGTCTGAGAGGATTAAGGCAGCAGGTGACTCCCCCT
CCTCGCCTGCCGTGTCCTGCTATTCTCAGGCAGCTCTAAGGAGAATTCTTATCACAGTTCAAGTGATTTCCAGAAGTTCCAGGGCTTCTG
AGAGACCATCAAGGGAACTTTAACAACTTGACAAATGTCCTTGAAGTAAGATGCCTCATCTTTAGGGAAAAATGGGGTTTGGATTTCTGC
TTAGGCAAAGTCTCCTGCAGTTCATCCTTCTCTGTCCTCTTCTTGCTTCAGGCTTGGGGACCGTCCCTGCTGTCCCCACTGTGGTGGCAA
TCAGGACCTAAGGTGAAGCAAACTTGAAGTTCTATCTGACAAGTTTAGGCAGTAAGAGAAGGAGGGAAATCGGAGCAAAGCTCCCTCACT
TTATTGTTGAGAAACTGGCATCTGGAAAGAGGAAGGAATTTGCCCAAAGTCAGTCAGCTGGGATAAAAACCTGGGTGTCCTGTCCAGAAA
GTGCAGGGTGCTTTCTGCTCTGTAGCAAGGCAGCAGACATCTCTGAGCCAGGCCCACCAACAGGCCCTTATCTGGTGGTTGGATCATGAT
CCCATTTTGCTTGGACATGCTCTCAGGAAGATAAAAACCATGGAGAAACACTAGGCCATTGACAAATGATCTGAGACAACTTTAGAAAAC
AATGTAGGATGAATGGAAAGAGAAAGAAAGGAAAGAAAGAAGAAAAAGAAAGAAGGAAAGAAAGAAAGAGAAAGGAAGGAAGGAAAGAAG
GAAGGAAAAGAAGGAAGGAAGGAAGGAATATAGTGTTATAAATACTGCACTCAACATTTTCCAAATTCTTGCCATTATTTTTCAAAAGTT
TAATAGTTTGCAGAAATAGATACTCAAGCCAAAGTCTGTTTTAGAGAAACTTTCCATGGAAAGTCAGAATTTCTACCACTTCCTTTTCTA
TCCACATTTCCAGTGCAGAAGAAACTGAGAAACAGAGCTTTTTGAAGAGAGGACAGGGCCATAGCAACAAGGACCTTCTTGGGGGATTAA
TGGGAGGTCAGTAGAATTAATAACCCTCCTTGGATGAGTGCTACTGTTTTCACATGGCTTCAGATGCTATCAACCTCAAAGAAATGATCT
CAACAGAGAAGCTTATTCTCTCCCAACTTCTACGGTAAAATCCAGGAGTATTTTCTCTGGGGATCTGCCCACAGGACAAAGTCCATAAAA
GCAAGTCCTGTCTGGACCATGTGGTTATCTGAAGCATTAGCCATCACCAGCACAACAAACGGGGCAGGGCTTTCCAAGGTGGGGCTGGTC
AGAAGGGAATCTTTGATAAGAGGCCCACAGGCAGGGAAAGCGAAATAGGGTTGATGAGACCAGGGGAGACCTAAAAAAAAGGCAGCTTTG
TGTCTTCTAGCTCCAAATATACCTGCCTTTTAGCTCACACACTGTCCTGGAGTTCTCAGACCTTTAGGGGCCCTAACACAGTTCAGTTCA
TACAGGGGTTCAAAAGGGACAGTGGCCCATTTGGGAGACCTTTAGGATCAATGGGAATCAATTCCATTGTTTTGCCTCAGAGTAAAGTTT
CTGGCTCGGGGACAATTATAAGTTGCAAAAAGGATAGAGGCATATCCCAAGTCTTCCTTCATTCCACAAATAATTACAAACAACCTACTG
TGTGCCAGGCACTATTCTTAGCACTGGAAATACACTAGTGAAGAAGCAGATGAGGACCCTGTTTATTGTTTCTCTCCAAGAAATTCTCCA
AGAATATTGTTTCTTGGAGAGAAATAATAAATAAACAAGACAATTTCTGAAAGCAATAAGTGCAATCAAGATAATTAAAGGATGCTAAAG
TGTGACTTGTGGGGATTGGGAGAGAGATGCACAGACAATATTAAAGAGGAGGCATTCGAGCTTTGTTGTGAACACCGGAAGTAACATGCC
GAGCGCCTGGGGGATGGAAACTCCTATAGCACCCCACAGGCTAACAGCAAGCAGGACAAGACAAAAAGGGCAGGTGGGACATGGTAGAGA
TGGACCCTACCCAGGAAACAGCTCCATCAGCATCTTAGCCTGCCCCACTCTAGCCACACATACCCACGTGTGCTCCTGAGTTCAGTGTGC
CCACCTCACTCCCACACCCTCACATAGACTTGGCAAGAGTAAGGAGGGAACTCCATAGAGACATTTTACCTATCTCAGGGGAGCAGCCAC
AAAGAAGCAAGTCTTGTAAAAGGTCTTTTGCAAAGGAGAGTGAACCCAGCAATGAGAGATCCTTAACAGCTAGTGCCCATTAGGGGGCTA
AACCTAAAGCCTGGGTGGTGATGGCTCAAACGCTAATGAGTCAGTGAATCCTTACCGACCCCCTGGCCTTTATAATCTGAGGCAACTTTG
GCTGCAGCCCGGGAATGTGCAGGGCACTAGGGAATACAAGGCCTTCTTCCCTGGTTGTCTTGTAATAAAACAGCCATGGGGTTGTCCCTC
CAGTCCGAGAGACTGTGATGAGGCCTACATAGCAGCGATGTGGTCAGGTAAAAATCAGGAACCCACTGAAATCTTGGGCAAGCCACCCTG
CCTGCTTGTGCCTCGGTTCTCTCATATGTCATATATAGGAGGTGAGGACTCCAGCTCCACCTGCCCCAGGTGGGTGTGGTGATGATGAGG
AAAGACAAGAGGCTTGCAAGGACCCTGAAGAGGTCGGAGCATCATACAGATTCCTTTATTAGCCCACATTCTGATGTTCCCTGGTGAGAC
TTGCCCCAAGCAATTGCTAGTAAATGGGGGTTAATTTCTTCTCCACCTCCCTACTGAACAAAAAAAGAAATGCCAGACTTACTAGGAGAA
TCGAGTTGCTTTGAGTTTCTTTTGTTTTGTTTTGTTTTGTTTTGTTTTAAGGCTCCCCTTACACACCCTCCTTTAAGCTTTGGGTTTTCT
CTCTTATAGTTTGTTGACACATGCTAAAAATGTCTTTGGAGAGAACTTCTGCCTGATAAACACCCAATTCTAGACTGTGGGTGGATTTTC
GAGCTGACGGTGGTCAATTCCTTTCATTAAGCAGTGATCTGATTTCTCCACATGGCCATTCTGCCTTCTTGGGGGCAGAGTAGATGGGCA
GCAGTTCACCTTTTCAGAGAAAGAGGTCTTCTAGCCACCTGGGCTGCTACTGAATGGTTTTCTCCAGGACGCTCTACCTAATGATTATTT
CTATAACATTAAGCATGGTAATAAGTAGCTTCCAATTCAATTCATCCTAAAGCCAAAGAAAATACAGCAACACACACACACACACACACA
CACACACACACACACACACACACACACCACTTTATGGCAATTCTTAACTGACATTCAATGACTTACTTCTTTTCTTAGAAAATTTCCACC
ACATTTCTATCCCCAAGCCAACATACAATGTGAAATGAAAGCCAGTGCGTGGAGTGCAGCTGCTAAAAATTTTCAGCACAGGGCTCTTTC
TGACTCTGCTCATGAGATGGTATCAGCCACCCAATGACTGGCGTATCTTGGTCCTGTGTCTTTCTTCTTACGCTGTGTTAATGTGTTTAC
TTTCCATTTGGCAGAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAACTGACCCCCACTGATAAAC
TCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTCATTAATGTGTAGGTGAATGCAAACT
CCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGATTCACGGTGCACATGCTGGCATTCA
ACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAAAATGTTTAGTTTAGAATA
AGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAAATGAACAGACAATGTCAAAACTACTGTGTCTGATA
CCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATTCTATAATATCTTCTTTGA
ATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGTCTCTTGGAGGAAGTTTTTTGTTTAA

>92855_92855_3_TNRC6A-PRKCB_TNRC6A_chr16_24741621_ENST00000395799_PRKCB_chr16_24192111_ENST00000303531_length(amino acids)=233AA_BP=24
MLVHFTHMRELEAKATKDVERNLSSDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL
LYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK

--------------------------------------------------------------
>92855_92855_4_TNRC6A-PRKCB_TNRC6A_chr16_24741621_ENST00000395799_PRKCB_chr16_24192111_ENST00000321728_length(transcript)=1302nt_BP=182nt
GGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGGGCTTGAGGCTCGCGAGCC
TCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGC
AGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGAT
GGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGG
TGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATG
GAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTG
GGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAG
CCCCCTTATAAGCCAAAAGCTAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAACTGACCCCCACT
GATAAACTCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTCATTAATGTGTAGGTGAAT
GCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGATTCACGGTGCACATGCTG
GCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAAAATGTTTAGTT
TAGAATAAGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAAATGAACAGACAATGTCAAAACTACTGTG
TCTGATACCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATTCTATAATATCT
TCTTTGAATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGTCTCTTGGAGGAAGTTTTT

>92855_92855_4_TNRC6A-PRKCB_TNRC6A_chr16_24741621_ENST00000395799_PRKCB_chr16_24192111_ENST00000321728_length(amino acids)=231AA_BP=24
MLVHFTHMRELEAKATKDVERNLSSDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL
LYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TNRC6A-PRKCB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTNRC6Achr16:24741621chr16:24192111ENST00000315183+2241_93217.6666666666666681914.0argonaute family proteins
HgeneTNRC6Achr16:24741621chr16:24192111ENST00000395799+2251_93217.6666666666666681963.0argonaute family proteins


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TNRC6A-PRKCB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TNRC6A-PRKCB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource