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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TNRC6B-NCF4 (FusionGDB2 ID:92878)

Fusion Gene Summary for TNRC6B-NCF4

Fusion gene summary

Fusion gene information	Fusion gene name: TNRC6B-NCF4
	Fusion gene ID: 92878
		Hgene	Tgene
	Gene symbol	TNRC6B	NCF4
	Gene ID	23112	4689
	Gene name	trinucleotide repeat containing adaptor 6B	neutrophil cytosolic factor 4
	Synonyms	-	CGD3\|NCF\|P40PHOX\|SH3PXD4
	Cytomap	22q13.1	22q12.3
	Type of gene	protein-coding	protein-coding
	Description	trinucleotide repeat-containing gene 6B proteintrinucleotide repeat containing 6B	neutrophil cytosol factor 4NCF-4SH3 and PX domain-containing protein 4neutrophil NADPH oxidase factor 4neutrophil cytosolic factor 4, 40kDap40-phox
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000335727, ENST00000454349, ENST00000301923, ENST00000402203, ENST00000497559,	ENST00000248899, ENST00000397147,
Fusion gene scores	* DoF score	36 X 24 X 16=13824	4 X 3 X 4=48
	# samples	43	4
	** MAII score	log2(43/13824*10)=-5.00669465257401 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TNRC6B [Title/Abstract] AND NCF4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TNRC6B(40574144)-NCF4(37260087), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TNRC6B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NCF4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CHOL	TCGA-W5-AA2I-01A	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+

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Fusion Gene ORF analysis for TNRC6B-NCF4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000335727	ENST00000248899	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+
In-frame	ENST00000335727	ENST00000397147	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+
In-frame	ENST00000454349	ENST00000248899	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+
In-frame	ENST00000454349	ENST00000397147	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+
intron-3CDS	ENST00000301923	ENST00000248899	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+
intron-3CDS	ENST00000301923	ENST00000397147	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+
intron-3CDS	ENST00000402203	ENST00000248899	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+
intron-3CDS	ENST00000402203	ENST00000397147	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+
intron-3CDS	ENST00000497559	ENST00000248899	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+
intron-3CDS	ENST00000497559	ENST00000397147	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000454349

TNRC6B

chr22

40574144

ENST00000248899

NCF4

chr22

37260087

1396

216

199

1203

334

ENST00000454349

TNRC6B

chr22

40574144

ENST00000397147

NCF4

chr22

37260087

1641

216

199

1230

343

ENST00000335727

TNRC6B

chr22

40574144

ENST00000248899

NCF4

chr22

37260087

1379

199

182

1186

334

ENST00000335727

TNRC6B

chr22

40574144

ENST00000397147

NCF4

chr22

37260087

1624

199

182

1213

343

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000454349	ENST00000248899	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+	0.001225903	0.9987741
ENST00000454349	ENST00000397147	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+	0.003441193	0.99655885
ENST00000335727	ENST00000248899	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+	0.001241916	0.9987581
ENST00000335727	ENST00000397147	TNRC6B	chr22	40574144	+	NCF4	chr22	37260087	+	0.003536711	0.99646336

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Fusion Genomic Features for TNRC6B-NCF4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TNRC6B	chr22	40574144	+	NCF4	chr22	37260086	+	1.64E-06	0.99999833
TNRC6B	chr22	40574144	+	NCF4	chr22	37260086	+	1.64E-06	0.99999833

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TNRC6B-NCF4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:40574144/chr22:37260087)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NCF4

chr22:40574144

chr22:37260087

ENST00000248899

170_229

340.0

Domain

SH3

Tgene

NCF4

chr22:40574144

chr22:37260087

ENST00000248899

19_140

340.0

Domain

Tgene

NCF4

chr22:40574144

chr22:37260087

ENST00000248899

237_329

340.0

Domain

PB1

Tgene

NCF4

chr22:40574144

chr22:37260087

ENST00000397147

170_229

406.3333333333333

Domain

SH3

Tgene

NCF4

chr22:40574144

chr22:37260087

ENST00000397147

19_140

406.3333333333333

Domain

Tgene

NCF4

chr22:40574144

chr22:37260087

ENST00000397147

237_329

406.3333333333333

Domain

PB1

Tgene

NCF4

chr22:40574144

chr22:37260087

ENST00000248899

58_60

340.0

Region

Note=Phosphatidylinositol 3-phosphate binding

Tgene

NCF4

chr22:40574144

chr22:37260087

ENST00000248899

92_94

340.0

Region

Note=Phosphatidylinositol 3-phosphate binding

Tgene

NCF4

chr22:40574144

chr22:37260087

ENST00000397147

58_60

406.3333333333333

Region

Note=Phosphatidylinositol 3-phosphate binding

Tgene

NCF4

chr22:40574144

chr22:37260087

ENST00000397147

92_94

406.3333333333333

Region

Note=Phosphatidylinositol 3-phosphate binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000301923

1_39

1030.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000335727

1_39

1724.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000402203

1_39

1030.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000454349

1_39

1834.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000301923

1150_1220

1030.0

Compositional bias

Note=Gln-rich

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000301923

825_880

1030.0

Compositional bias

Note=Pro-rich

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000335727

1150_1220

1724.0

Compositional bias

Note=Gln-rich

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000335727

825_880

1724.0

Compositional bias

Note=Pro-rich

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000402203

1150_1220

1030.0

Compositional bias

Note=Gln-rich

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000402203

825_880

1030.0

Compositional bias

Note=Pro-rich

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000454349

1150_1220

1834.0

Compositional bias

Note=Gln-rich

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000454349

825_880

1834.0

Compositional bias

Note=Pro-rich

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000301923

1648_1720

1030.0

Domain

Note=RRM

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000335727

1648_1720

1724.0

Domain

Note=RRM

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000402203

1648_1720

1030.0

Domain

Note=RRM

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000454349

1648_1720

1834.0

Domain

Note=RRM

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000301923

1472_1490

1030.0

Region

Note=PABPC1-interacting motif-2 (PAM2)

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000335727

1472_1490

1724.0

Region

Note=PABPC1-interacting motif-2 (PAM2)

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000402203

1472_1490

1030.0

Region

Note=PABPC1-interacting motif-2 (PAM2)

Hgene

TNRC6B

chr22:40574144

chr22:37260087

ENST00000454349

1472_1490

1834.0

Region

Note=PABPC1-interacting motif-2 (PAM2)

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Fusion Gene Sequence for TNRC6B-NCF4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>92878_92878_1_TNRC6B-NCF4_TNRC6B_chr22_40574144_ENST00000335727_NCF4_chr22_37260087_ENST00000248899_length(transcript)=1379nt_BP=199nt
GAGAGAGCAAGAGGGAGAGTGTGTGAGAGAGAGTTAGTTCAAGCCAAAATGGCCGACAGAGTCTCTGCTGGTTTCTGAATATTTAAAATA
CAAAAAAACAGATAGACAAAAAGAATTCATTTTTTGGACCTTTTTTCATTTCCATTTCTACCTTGTATGCCTCAATTTGCTGGATTTAAG
CACTGCTGCACTTTATGAGTGACTTTGAACAGCTTCCGGATGATGTTGCCATCTCGGCCAACATTGCTGACATCGAGGAGAAGAGAGGCT
TCACCAGCCACTTTGTTTTCGTCATCGAGGTGAAGACAAAAGGAGGATCCAAGTACCTCATCTACCGCCGCTACCGCCAGTTCCATGCTT
TGCAGAGCAAGCTGGAGGAGCGCTTCGGGCCAGACAGCAAGAGCAGTGCCCTGGCCTGTACCCTGCCCACACTCCCAGCCAAAGTCTACG
TGGGTGTGAAACAGGAGATCGCCGAGATGCGGATACCTGCCCTCAACGCCTACATGAAGAGCCTGCTCAGCCTGCCGGTCTGGGTGCTGA
TGGATGAGGACGTCCGGATCTTCTTTTACCAGTCGCCCTATGACTCAGAGCAGGTGCCCCAGGCACTCCGCCGGCTCCGCCCGCGCACCC
GGAAAGTCAAGAGCGTGTCCCCACAGGGCAACAGCGTTGACCGCATGGCAGCTCCGAGAGCAGAGGCTCTATTTGACTTCACTGGAAACA
GCAAACTGGAGCTGAATTTCAAAGCTGGAGATGTGATCTTCCTCCTCAGTCGGATCAACAAAGACTGGCTGGAGGGCACTGTCCGGGGAG
CCACGGGCATCTTCCCTCTCTCCTTCGTGAAGATCCTCAAAGACTTCCCTGAGGAGGACGACCCCACCAACTGGCTGCGTTGCTACTACT
ACGAAGACACCATCAGCACCATCAAGGACATCGCGGTGGAGGAAGATCTCAGCAGCACTCCCCTATTGAAAGACCTGCTGGAGCTCACAA
GGCGGGAGTTCCAGAGAGAGGACATAGCTCTGAATTACCGGGACGCTGAGGGGGATCTGGTTCGGCTGCTGTCGGATGAGGACGTAGCGC
TCATGGTGCGGCAGGCTCGTGGCCTCCCCTCCCAGAAGCGCCTCTTCCCCTGGAAGCTGCACATCACGCAGAAGGACAACTACAGGGTCT
ACAACACGATGCCATGAGCTGACGGTGTCCCTGGAGCAGTGAGGGGACACCAGCAAAAACCTTCAGCTCTCAGAGGAGATTGGGACCAGG
AAAACCTGGGAGGATGGGCAGACTTCCTGTCTTTGAGGCTAATGGACCCGTGGGGCTTGTAATCTGTCTCTTTCTACTATTTACATCTGA

>92878_92878_1_TNRC6B-NCF4_TNRC6B_chr22_40574144_ENST00000335727_NCF4_chr22_37260087_ENST00000248899_length(amino acids)=334AA_BP=5
MLHFMSDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYV
GVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNS
KLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTR

--------------------------------------------------------------
>92878_92878_2_TNRC6B-NCF4_TNRC6B_chr22_40574144_ENST00000335727_NCF4_chr22_37260087_ENST00000397147_length(transcript)=1624nt_BP=199nt
GAGAGAGCAAGAGGGAGAGTGTGTGAGAGAGAGTTAGTTCAAGCCAAAATGGCCGACAGAGTCTCTGCTGGTTTCTGAATATTTAAAATA
CAAAAAAACAGATAGACAAAAAGAATTCATTTTTTGGACCTTTTTTCATTTCCATTTCTACCTTGTATGCCTCAATTTGCTGGATTTAAG
CACTGCTGCACTTTATGAGTGACTTTGAACAGCTTCCGGATGATGTTGCCATCTCGGCCAACATTGCTGACATCGAGGAGAAGAGAGGCT
TCACCAGCCACTTTGTTTTCGTCATCGAGGTGAAGACAAAAGGAGGATCCAAGTACCTCATCTACCGCCGCTACCGCCAGTTCCATGCTT
TGCAGAGCAAGCTGGAGGAGCGCTTCGGGCCAGACAGCAAGAGCAGTGCCCTGGCCTGTACCCTGCCCACACTCCCAGCCAAAGTCTACG
TGGGTGTGAAACAGGAGATCGCCGAGATGCGGATACCTGCCCTCAACGCCTACATGAAGAGCCTGCTCAGCCTGCCGGTCTGGGTGCTGA
TGGATGAGGACGTCCGGATCTTCTTTTACCAGTCGCCCTATGACTCAGAGCAGGTGCCCCAGGCACTCCGCCGGCTCCGCCCGCGCACCC
GGAAAGTCAAGAGCGTGTCCCCACAGGGCAACAGCGTTGACCGCATGGCAGCTCCGAGAGCAGAGGCTCTATTTGACTTCACTGGAAACA
GCAAACTGGAGCTGAATTTCAAAGCTGGAGATGTGATCTTCCTCCTCAGTCGGATCAACAAAGACTGGCTGGAGGGCACTGTCCGGGGAG
CCACGGGCATCTTCCCTCTCTCCTTCGTGAAGATCCTCAAAGACTTCCCTGAGGAGGACGACCCCACCAACTGGCTGCGTTGCTACTACT
ACGAAGACACCATCAGCACCATCAAGTCTGTGGCCTGGGAGGGAGGGGCCTGTCCAGCCTTCCTGCCATCCCTACGACCACTGCCCCTCA
CATCACCTTCTCATGGGTCCCTCTCCCACTCCAAAGCCCCCAGTGGCTCCCAGATGAGCCACAATGCTGTAACAAGCCATCAACGTCCAG
GGTGGCCTGGCCAGCCTCATTCCCCTTTCCCCCACCCCACACCCCACTTCCAGCCTGATGCCTCCTTACTCCAGCCTGTCACCCCCTTAG
GGACATCGCGGTGGAGGAAGATCTCAGCAGCACTCCCCTATTGAAAGACCTGCTGGAGCTCACAAGGCGGGAGTTCCAGAGAGAGGACAT
AGCTCTGAATTACCGGGACGCTGAGGGGGATCTGGTTCGGCTGCTGTCGGATGAGGACGTAGCGCTCATGGTGCGGCAGGCTCGTGGCCT
CCCCTCCCAGAAGCGCCTCTTCCCCTGGAAGCTGCACATCACGCAGAAGGACAACTACAGGGTCTACAACACGATGCCATGAGCTGACGG
TGTCCCTGGAGCAGTGAGGGGACACCAGCAAAAACCTTCAGCTCTCAGAGGAGATTGGGACCAGGAAAACCTGGGAGGATGGGCAGACTT
CCTGTCTTTGAGGCTAATGGACCCGTGGGGCTTGTAATCTGTCTCTTTCTACTATTTACATCTGATTTAAATAAACCATTCCATCTGAAA

>92878_92878_2_TNRC6B-NCF4_TNRC6B_chr22_40574144_ENST00000335727_NCF4_chr22_37260087_ENST00000397147_length(amino acids)=343AA_BP=5
MLHFMSDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYV
GVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNS
KLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIKSVAWEGGACPAFLPSLRPLPLT

--------------------------------------------------------------
>92878_92878_3_TNRC6B-NCF4_TNRC6B_chr22_40574144_ENST00000454349_NCF4_chr22_37260087_ENST00000248899_length(transcript)=1396nt_BP=216nt
AGAGACAGAGAGGGAGAGAGAGAGCAAGAGGGAGAGTGTGTGAGAGAGAGTTAGTTCAAGCCAAAATGGCCGACAGAGTCTCTGCTGGTT
TCTGAATATTTAAAATACAAAAAAACAGATAGACAAAAAGAATTCATTTTTTGGACCTTTTTTCATTTCCATTTCTACCTTGTATGCCTC
AATTTGCTGGATTTAAGCACTGCTGCACTTTATGAGTGACTTTGAACAGCTTCCGGATGATGTTGCCATCTCGGCCAACATTGCTGACAT
CGAGGAGAAGAGAGGCTTCACCAGCCACTTTGTTTTCGTCATCGAGGTGAAGACAAAAGGAGGATCCAAGTACCTCATCTACCGCCGCTA
CCGCCAGTTCCATGCTTTGCAGAGCAAGCTGGAGGAGCGCTTCGGGCCAGACAGCAAGAGCAGTGCCCTGGCCTGTACCCTGCCCACACT
CCCAGCCAAAGTCTACGTGGGTGTGAAACAGGAGATCGCCGAGATGCGGATACCTGCCCTCAACGCCTACATGAAGAGCCTGCTCAGCCT
GCCGGTCTGGGTGCTGATGGATGAGGACGTCCGGATCTTCTTTTACCAGTCGCCCTATGACTCAGAGCAGGTGCCCCAGGCACTCCGCCG
GCTCCGCCCGCGCACCCGGAAAGTCAAGAGCGTGTCCCCACAGGGCAACAGCGTTGACCGCATGGCAGCTCCGAGAGCAGAGGCTCTATT
TGACTTCACTGGAAACAGCAAACTGGAGCTGAATTTCAAAGCTGGAGATGTGATCTTCCTCCTCAGTCGGATCAACAAAGACTGGCTGGA
GGGCACTGTCCGGGGAGCCACGGGCATCTTCCCTCTCTCCTTCGTGAAGATCCTCAAAGACTTCCCTGAGGAGGACGACCCCACCAACTG
GCTGCGTTGCTACTACTACGAAGACACCATCAGCACCATCAAGGACATCGCGGTGGAGGAAGATCTCAGCAGCACTCCCCTATTGAAAGA
CCTGCTGGAGCTCACAAGGCGGGAGTTCCAGAGAGAGGACATAGCTCTGAATTACCGGGACGCTGAGGGGGATCTGGTTCGGCTGCTGTC
GGATGAGGACGTAGCGCTCATGGTGCGGCAGGCTCGTGGCCTCCCCTCCCAGAAGCGCCTCTTCCCCTGGAAGCTGCACATCACGCAGAA
GGACAACTACAGGGTCTACAACACGATGCCATGAGCTGACGGTGTCCCTGGAGCAGTGAGGGGACACCAGCAAAAACCTTCAGCTCTCAG
AGGAGATTGGGACCAGGAAAACCTGGGAGGATGGGCAGACTTCCTGTCTTTGAGGCTAATGGACCCGTGGGGCTTGTAATCTGTCTCTTT

>92878_92878_3_TNRC6B-NCF4_TNRC6B_chr22_40574144_ENST00000454349_NCF4_chr22_37260087_ENST00000248899_length(amino acids)=334AA_BP=5
MLHFMSDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYV
GVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNS
KLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTR

--------------------------------------------------------------
>92878_92878_4_TNRC6B-NCF4_TNRC6B_chr22_40574144_ENST00000454349_NCF4_chr22_37260087_ENST00000397147_length(transcript)=1641nt_BP=216nt
AGAGACAGAGAGGGAGAGAGAGAGCAAGAGGGAGAGTGTGTGAGAGAGAGTTAGTTCAAGCCAAAATGGCCGACAGAGTCTCTGCTGGTT
TCTGAATATTTAAAATACAAAAAAACAGATAGACAAAAAGAATTCATTTTTTGGACCTTTTTTCATTTCCATTTCTACCTTGTATGCCTC
AATTTGCTGGATTTAAGCACTGCTGCACTTTATGAGTGACTTTGAACAGCTTCCGGATGATGTTGCCATCTCGGCCAACATTGCTGACAT
CGAGGAGAAGAGAGGCTTCACCAGCCACTTTGTTTTCGTCATCGAGGTGAAGACAAAAGGAGGATCCAAGTACCTCATCTACCGCCGCTA
CCGCCAGTTCCATGCTTTGCAGAGCAAGCTGGAGGAGCGCTTCGGGCCAGACAGCAAGAGCAGTGCCCTGGCCTGTACCCTGCCCACACT
CCCAGCCAAAGTCTACGTGGGTGTGAAACAGGAGATCGCCGAGATGCGGATACCTGCCCTCAACGCCTACATGAAGAGCCTGCTCAGCCT
GCCGGTCTGGGTGCTGATGGATGAGGACGTCCGGATCTTCTTTTACCAGTCGCCCTATGACTCAGAGCAGGTGCCCCAGGCACTCCGCCG
GCTCCGCCCGCGCACCCGGAAAGTCAAGAGCGTGTCCCCACAGGGCAACAGCGTTGACCGCATGGCAGCTCCGAGAGCAGAGGCTCTATT
TGACTTCACTGGAAACAGCAAACTGGAGCTGAATTTCAAAGCTGGAGATGTGATCTTCCTCCTCAGTCGGATCAACAAAGACTGGCTGGA
GGGCACTGTCCGGGGAGCCACGGGCATCTTCCCTCTCTCCTTCGTGAAGATCCTCAAAGACTTCCCTGAGGAGGACGACCCCACCAACTG
GCTGCGTTGCTACTACTACGAAGACACCATCAGCACCATCAAGTCTGTGGCCTGGGAGGGAGGGGCCTGTCCAGCCTTCCTGCCATCCCT
ACGACCACTGCCCCTCACATCACCTTCTCATGGGTCCCTCTCCCACTCCAAAGCCCCCAGTGGCTCCCAGATGAGCCACAATGCTGTAAC
AAGCCATCAACGTCCAGGGTGGCCTGGCCAGCCTCATTCCCCTTTCCCCCACCCCACACCCCACTTCCAGCCTGATGCCTCCTTACTCCA
GCCTGTCACCCCCTTAGGGACATCGCGGTGGAGGAAGATCTCAGCAGCACTCCCCTATTGAAAGACCTGCTGGAGCTCACAAGGCGGGAG
TTCCAGAGAGAGGACATAGCTCTGAATTACCGGGACGCTGAGGGGGATCTGGTTCGGCTGCTGTCGGATGAGGACGTAGCGCTCATGGTG
CGGCAGGCTCGTGGCCTCCCCTCCCAGAAGCGCCTCTTCCCCTGGAAGCTGCACATCACGCAGAAGGACAACTACAGGGTCTACAACACG
ATGCCATGAGCTGACGGTGTCCCTGGAGCAGTGAGGGGACACCAGCAAAAACCTTCAGCTCTCAGAGGAGATTGGGACCAGGAAAACCTG
GGAGGATGGGCAGACTTCCTGTCTTTGAGGCTAATGGACCCGTGGGGCTTGTAATCTGTCTCTTTCTACTATTTACATCTGATTTAAATA

>92878_92878_4_TNRC6B-NCF4_TNRC6B_chr22_40574144_ENST00000454349_NCF4_chr22_37260087_ENST00000397147_length(amino acids)=343AA_BP=5
MLHFMSDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYV
GVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNS
KLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIKSVAWEGGACPAFLPSLRPLPLT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TNRC6B-NCF4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	TNRC6B	chr22:40574144	chr22:37260087	ENST00000301923	+	1	24	1_994	0	1030.0	argonaute proteins
Hgene	TNRC6B	chr22:40574144	chr22:37260087	ENST00000335727	+	1	21	1_994	1.6666666666666667	1724.0	argonaute proteins
Hgene	TNRC6B	chr22:40574144	chr22:37260087	ENST00000402203	+	1	24	1_994	0	1030.0	argonaute proteins
Hgene	TNRC6B	chr22:40574144	chr22:37260087	ENST00000454349	+	1	23	1_994	1.6666666666666667	1834.0	argonaute proteins

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TNRC6B-NCF4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TNRC6B-NCF4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source