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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TNS3-ZNRF2 (FusionGDB2 ID:92952)

Fusion Gene Summary for TNS3-ZNRF2

check button Fusion gene summary
Fusion gene informationFusion gene name: TNS3-ZNRF2
Fusion gene ID: 92952
HgeneTgene
Gene symbol

TNS3

ZNRF2

Gene ID

64759

223082

Gene nametensin 3zinc and ring finger 2
SynonymsTEM6|TENS1RNF202
Cytomap

7p12.3

7p14.3

Type of geneprotein-codingprotein-coding
Descriptiontensin-3tensin-like SH2 domain containing 1tensin-like SH2 domain-containing protein 1thyroid specific PTB domain proteintumor endothelial marker 6E3 ubiquitin-protein ligase ZNRF2RING finger protein 202RING-type E3 ubiquitin transferase ZNRF2protein Ells2zinc and ring finger 2, E3 ubiquitin protein ligasezinc finger/RING finger 2zinc/RING finger protein 2
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000311160, ENST00000355730, 
ENST00000398879, ENST00000442536, 
ENST00000458317, ENST00000474346, 
ENST00000459998, ENST00000323037, 
Fusion gene scores* DoF score21 X 21 X 13=57337 X 4 X 4=112
# samples 287
** MAII scorelog2(28/5733*10)=-4.35579154675365
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/112*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNS3 [Title/Abstract] AND ZNRF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTNS3(47474880)-ZNRF2(30401993), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TNS3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNRF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AQ-A04L-01BTNS3chr7

47474880

-ZNRF2chr7

30401993

+


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Fusion Gene ORF analysis for TNS3-ZNRF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000311160ENST00000459998TNS3chr7

47474880

-ZNRF2chr7

30401993

+
5CDS-intronENST00000355730ENST00000459998TNS3chr7

47474880

-ZNRF2chr7

30401993

+
5CDS-intronENST00000398879ENST00000459998TNS3chr7

47474880

-ZNRF2chr7

30401993

+
5CDS-intronENST00000442536ENST00000459998TNS3chr7

47474880

-ZNRF2chr7

30401993

+
5CDS-intronENST00000458317ENST00000459998TNS3chr7

47474880

-ZNRF2chr7

30401993

+
In-frameENST00000311160ENST00000323037TNS3chr7

47474880

-ZNRF2chr7

30401993

+
In-frameENST00000355730ENST00000323037TNS3chr7

47474880

-ZNRF2chr7

30401993

+
In-frameENST00000398879ENST00000323037TNS3chr7

47474880

-ZNRF2chr7

30401993

+
In-frameENST00000442536ENST00000323037TNS3chr7

47474880

-ZNRF2chr7

30401993

+
In-frameENST00000458317ENST00000323037TNS3chr7

47474880

-ZNRF2chr7

30401993

+
intron-3CDSENST00000474346ENST00000323037TNS3chr7

47474880

-ZNRF2chr7

30401993

+
intron-intronENST00000474346ENST00000459998TNS3chr7

47474880

-ZNRF2chr7

30401993

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311160TNS3chr747474880-ENST00000323037ZNRF2chr730401993+2420682115693192
ENST00000355730TNS3chr747474880-ENST00000323037ZNRF2chr730401993+242969182702206
ENST00000398879TNS3chr747474880-ENST00000323037ZNRF2chr730401993+242969182702206
ENST00000442536TNS3chr747474880-ENST00000323037ZNRF2chr730401993+242969182702206
ENST00000458317TNS3chr747474880-ENST00000323037ZNRF2chr730401993+242969182702206

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311160ENST00000323037TNS3chr747474880-ZNRF2chr730401993+0.107313650.8926864
ENST00000355730ENST00000323037TNS3chr747474880-ZNRF2chr730401993+0.162114530.8378855
ENST00000398879ENST00000323037TNS3chr747474880-ZNRF2chr730401993+0.162114530.8378855
ENST00000442536ENST00000323037TNS3chr747474880-ZNRF2chr730401993+0.162114530.8378855
ENST00000458317ENST00000323037TNS3chr747474880-ZNRF2chr730401993+0.162114530.8378855

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Fusion Genomic Features for TNS3-ZNRF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TNS3chr747474879-ZNRF2chr730401992+7.47E-060.9999925
TNS3chr747474879-ZNRF2chr730401992+7.47E-060.9999925

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TNS3-ZNRF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:47474880/chr7:30401993)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNS3chr7:47474880chr7:30401993ENST00000311160-831941_9441081446.0Compositional biasNote=Poly-Ser
HgeneTNS3chr7:47474880chr7:30401993ENST00000398879-831941_9441081446.0Compositional biasNote=Poly-Ser
HgeneTNS3chr7:47474880chr7:30401993ENST00000442536-815941_944108204.66666666666666Compositional biasNote=Poly-Ser
HgeneTNS3chr7:47474880chr7:30401993ENST00000458317-814941_944108251.0Compositional biasNote=Poly-Ser
HgeneTNS3chr7:47474880chr7:30401993ENST00000311160-8311172_12821081446.0DomainSH2
HgeneTNS3chr7:47474880chr7:30401993ENST00000311160-831175_3011081446.0DomainC2 tensin-type
HgeneTNS3chr7:47474880chr7:30401993ENST00000311160-8311_1701081446.0DomainPhosphatase tensin-type
HgeneTNS3chr7:47474880chr7:30401993ENST00000398879-8311172_12821081446.0DomainSH2
HgeneTNS3chr7:47474880chr7:30401993ENST00000398879-831175_3011081446.0DomainC2 tensin-type
HgeneTNS3chr7:47474880chr7:30401993ENST00000398879-8311_1701081446.0DomainPhosphatase tensin-type
HgeneTNS3chr7:47474880chr7:30401993ENST00000442536-8151172_1282108204.66666666666666DomainSH2
HgeneTNS3chr7:47474880chr7:30401993ENST00000442536-815175_301108204.66666666666666DomainC2 tensin-type
HgeneTNS3chr7:47474880chr7:30401993ENST00000442536-8151_170108204.66666666666666DomainPhosphatase tensin-type
HgeneTNS3chr7:47474880chr7:30401993ENST00000458317-8141172_1282108251.0DomainSH2
HgeneTNS3chr7:47474880chr7:30401993ENST00000458317-814175_301108251.0DomainC2 tensin-type
HgeneTNS3chr7:47474880chr7:30401993ENST00000458317-8141_170108251.0DomainPhosphatase tensin-type
TgeneZNRF2chr7:47474880chr7:30401993ENST0000032303725124_127223289.0Compositional biasNote=Poly-Gly
TgeneZNRF2chr7:47474880chr7:30401993ENST000003230372536_40223289.0Compositional biasNote=Poly-Gly
TgeneZNRF2chr7:47474880chr7:30401993ENST000003230372541_97223289.0Compositional biasNote=Ala-rich
TgeneZNRF2chr7:47474880chr7:30401993ENST0000032303725199_240223289.0Zinc fingerRING-type%3B atypical


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Fusion Gene Sequence for TNS3-ZNRF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92952_92952_1_TNS3-ZNRF2_TNS3_chr7_47474880_ENST00000311160_ZNRF2_chr7_30401993_ENST00000323037_length(transcript)=2420nt_BP=682nt
AGCCAGCCAGGAGGACGGGCCCGCCCGCGCGCTACTCGGAGCCCAGCCTCGTTGCGGCCATCGCCCTGCCGGACCGCGCCTCAGGCTCCC
CCAGCCGGAAGAATTAACCTCGAGTCTGCACGCTTTTAAGAACAAGGCCTTTAAAAAATCCAAAGTGTGTGGAGTTTGCAAACAAATTAT
TGACGGTCAAGGTATTTCATGCCGAGCCTGCAAGTATTCCTGCCACAAGAAATGTGAAGCCAAGGTGGTGATTCCCTGCGGTGTGCAAGT
CCGACTGGAACAGGCTCCAGGGAGTTCCACGCTGTCCAGTTCTCTCTGCCGTGATAAACCTCTGCGGCCCGTCATCCTGAGTCCCACCAT
GGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGAGTCCTACCT
GCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAGATATGACCT
TACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATGCAAGGCGCA
GGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATAGATCTTGCC
CTGAGCACCCTTCAGATTAAGCGTCAGCTTCCTGTTTTATAGGTTTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGGATATGAAAA
TCTGTCTCTGGAGAAACAAAGACGCAGGCATACTCAGCCAGAAATCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGACAATCGTACT
GGGGTAAAAAAACCCTGCTGAAGAGAGGACAGTGACCACAGAACTCAGTGTACCAAACATGCATACAAAGGACACACAGGGATTTTGAAA
ATGCTGCACATCCCTTAATAGTCATCTACATAGGTAATACTGATAAACATTTTGTATTCAGACGCCAAAGTTAACTGATTTAAAAGTTGA
TTTACTTTTTATTAAGTTCTCCAGAGCTGCACAACTAGTTATGTTTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTGTTTTCCCCA
ACATAATGTTCATAATGTTTCTGCATTCATCTGTTCTTAAATTGAAAAACATATAATTTACTTCTTATAAATTGAAGTCTTAAATGTGAA
ACCAAGAAATGTAATCAAGCAGTAAAAACATCTGAATGTAGACCATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTGGAAAATAGA
CTTCTACATAGGAAAGCTAAAATATGTTAATATTTTTAAATTAAAGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCATATTACATA
ATTACATTTTAATTAAATATAGAATATTCTACTGAATTGCAATTTATTAAATATTCTTATCCTCTTAAATAAAACTGCTCAACAGTTAAT
CAGCAGTGAATCATCTTGCAGCTATGCAATTTAAAAAAAATACAGATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTGTTTTAACGG
GTATCTTTTGTTTGTTCTTTTCACTTAATTATTTTATTGTGCTTTGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAATGTTTAGCAG
GCTGTAAACTTAAGAAAAGGGTAAAATAAAATTTTCTGGAGAGGAACTTGGAATTTGAGGGAGATTTTATATACCTTTAAAAACTGTAAT
TTAATTGGGATGCCAGGTTTATAGCAATTTGCAACTTTAATTTTCCAGATAATCTGGAGGTTAGCATTTGATAAATGATTTTTTAAAGTA
GATATGAAGATTTTGTTAATTTATAATTTATTCATGTGTTATTACTGTAATTGAAAATGTTATAGACACTTTTAAATTCAGTTTGTGTAG
AAAGAAATGTGTTAAACAAAATTATGTTAATAAATATTCCCACATAATACATCTGAATGGTTAAAAATACTGGAAGAGTTGTCAGGGCTA
CAATAGTGAATGTCCTTTTTTTTAATATCAAAAATATCGATAAGTAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCAGTGAATAGG
TGGTGTACTTTACTTGGTATAATTTAAAGTTGCACAGTAAGTACTGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTATTTAAGAAT
TTGCTGTTTTATTTAACGCTGCTACTCTTAATCTTCTCTAAATTTTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTTAAAAGGGCA

>92952_92952_1_TNS3-ZNRF2_TNS3_chr7_47474880_ENST00000311160_ZNRF2_chr7_30401993_ENST00000323037_length(amino acids)=192AA_BP=
MHAFKNKAFKKSKVCGVCKQIIDGQGISCRACKYSCHKKCEAKVVIPCGVQVRLEQAPGSSTLSSSLCRDKPLRPVILSPTMEEGHGLDL
TYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNL

--------------------------------------------------------------
>92952_92952_2_TNS3-ZNRF2_TNS3_chr7_47474880_ENST00000355730_ZNRF2_chr7_30401993_ENST00000323037_length(transcript)=2429nt_BP=691nt
AGAATGGGAAACTGCCTTGGGAGAAGCCCCAAGTGAGCCCAAGGGCGCAGAGCAGAAGGACCCTGGAGTGTAAGAGCCTAGATTGCAAGC
CTGGCAGGAGGAGCCGGAAGAATTAACCTCGAGTCTGCACGCTTTTAAGAACAAGGCCTTTAAAAAATCCAAAGTGTGTGGAGTTTGCAA
ACAAATTATTGACGGTCAAGGTATTTCATGCCGAGCCTGCAAGTATTCCTGCCACAAGAAATGTGAAGCCAAGGTGGTGATTCCCTGCGG
TGTGCAAGTCCGACTGGAACAGGCTCCAGGGAGTTCCACGCTGTCCAGTTCTCTCTGCCGTGATAAACCTCTGCGGCCCGTCATCCTGAG
TCCCACCATGGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGA
GTCCTACCTGCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAG
ATATGACCTTACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATG
CAAGGCGCAGGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATA
GATCTTGCCCTGAGCACCCTTCAGATTAAGCGTCAGCTTCCTGTTTTATAGGTTTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGG
ATATGAAAATCTGTCTCTGGAGAAACAAAGACGCAGGCATACTCAGCCAGAAATCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGAC
AATCGTACTGGGGTAAAAAAACCCTGCTGAAGAGAGGACAGTGACCACAGAACTCAGTGTACCAAACATGCATACAAAGGACACACAGGG
ATTTTGAAAATGCTGCACATCCCTTAATAGTCATCTACATAGGTAATACTGATAAACATTTTGTATTCAGACGCCAAAGTTAACTGATTT
AAAAGTTGATTTACTTTTTATTAAGTTCTCCAGAGCTGCACAACTAGTTATGTTTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTG
TTTTCCCCAACATAATGTTCATAATGTTTCTGCATTCATCTGTTCTTAAATTGAAAAACATATAATTTACTTCTTATAAATTGAAGTCTT
AAATGTGAAACCAAGAAATGTAATCAAGCAGTAAAAACATCTGAATGTAGACCATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTG
GAAAATAGACTTCTACATAGGAAAGCTAAAATATGTTAATATTTTTAAATTAAAGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCA
TATTACATAATTACATTTTAATTAAATATAGAATATTCTACTGAATTGCAATTTATTAAATATTCTTATCCTCTTAAATAAAACTGCTCA
ACAGTTAATCAGCAGTGAATCATCTTGCAGCTATGCAATTTAAAAAAAATACAGATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTG
TTTTAACGGGTATCTTTTGTTTGTTCTTTTCACTTAATTATTTTATTGTGCTTTGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAAT
GTTTAGCAGGCTGTAAACTTAAGAAAAGGGTAAAATAAAATTTTCTGGAGAGGAACTTGGAATTTGAGGGAGATTTTATATACCTTTAAA
AACTGTAATTTAATTGGGATGCCAGGTTTATAGCAATTTGCAACTTTAATTTTCCAGATAATCTGGAGGTTAGCATTTGATAAATGATTT
TTTAAAGTAGATATGAAGATTTTGTTAATTTATAATTTATTCATGTGTTATTACTGTAATTGAAAATGTTATAGACACTTTTAAATTCAG
TTTGTGTAGAAAGAAATGTGTTAAACAAAATTATGTTAATAAATATTCCCACATAATACATCTGAATGGTTAAAAATACTGGAAGAGTTG
TCAGGGCTACAATAGTGAATGTCCTTTTTTTTAATATCAAAAATATCGATAAGTAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCA
GTGAATAGGTGGTGTACTTTACTTGGTATAATTTAAAGTTGCACAGTAAGTACTGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTA
TTTAAGAATTTGCTGTTTTATTTAACGCTGCTACTCTTAATCTTCTCTAAATTTTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTT

>92952_92952_2_TNS3-ZNRF2_TNS3_chr7_47474880_ENST00000355730_ZNRF2_chr7_30401993_ENST00000323037_length(amino acids)=206AA_BP=
MQAWQEEPEELTSSLHAFKNKAFKKSKVCGVCKQIIDGQGISCRACKYSCHKKCEAKVVIPCGVQVRLEQAPGSSTLSSSLCRDKPLRPV
ILSPTMEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMC

--------------------------------------------------------------
>92952_92952_3_TNS3-ZNRF2_TNS3_chr7_47474880_ENST00000398879_ZNRF2_chr7_30401993_ENST00000323037_length(transcript)=2429nt_BP=691nt
AGAATGGGAAACTGCCTTGGGAGAAGCCCCAAGTGAGCCCAAGGGCGCAGAGCAGAAGGACCCTGGAGTGTAAGAGCCTAGATTGCAAGC
CTGGCAGGAGGAGCCGGAAGAATTAACCTCGAGTCTGCACGCTTTTAAGAACAAGGCCTTTAAAAAATCCAAAGTGTGTGGAGTTTGCAA
ACAAATTATTGACGGTCAAGGTATTTCATGCCGAGCCTGCAAGTATTCCTGCCACAAGAAATGTGAAGCCAAGGTGGTGATTCCCTGCGG
TGTGCAAGTCCGACTGGAACAGGCTCCAGGGAGTTCCACGCTGTCCAGTTCTCTCTGCCGTGATAAACCTCTGCGGCCCGTCATCCTGAG
TCCCACCATGGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGA
GTCCTACCTGCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAG
ATATGACCTTACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATG
CAAGGCGCAGGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATA
GATCTTGCCCTGAGCACCCTTCAGATTAAGCGTCAGCTTCCTGTTTTATAGGTTTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGG
ATATGAAAATCTGTCTCTGGAGAAACAAAGACGCAGGCATACTCAGCCAGAAATCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGAC
AATCGTACTGGGGTAAAAAAACCCTGCTGAAGAGAGGACAGTGACCACAGAACTCAGTGTACCAAACATGCATACAAAGGACACACAGGG
ATTTTGAAAATGCTGCACATCCCTTAATAGTCATCTACATAGGTAATACTGATAAACATTTTGTATTCAGACGCCAAAGTTAACTGATTT
AAAAGTTGATTTACTTTTTATTAAGTTCTCCAGAGCTGCACAACTAGTTATGTTTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTG
TTTTCCCCAACATAATGTTCATAATGTTTCTGCATTCATCTGTTCTTAAATTGAAAAACATATAATTTACTTCTTATAAATTGAAGTCTT
AAATGTGAAACCAAGAAATGTAATCAAGCAGTAAAAACATCTGAATGTAGACCATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTG
GAAAATAGACTTCTACATAGGAAAGCTAAAATATGTTAATATTTTTAAATTAAAGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCA
TATTACATAATTACATTTTAATTAAATATAGAATATTCTACTGAATTGCAATTTATTAAATATTCTTATCCTCTTAAATAAAACTGCTCA
ACAGTTAATCAGCAGTGAATCATCTTGCAGCTATGCAATTTAAAAAAAATACAGATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTG
TTTTAACGGGTATCTTTTGTTTGTTCTTTTCACTTAATTATTTTATTGTGCTTTGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAAT
GTTTAGCAGGCTGTAAACTTAAGAAAAGGGTAAAATAAAATTTTCTGGAGAGGAACTTGGAATTTGAGGGAGATTTTATATACCTTTAAA
AACTGTAATTTAATTGGGATGCCAGGTTTATAGCAATTTGCAACTTTAATTTTCCAGATAATCTGGAGGTTAGCATTTGATAAATGATTT
TTTAAAGTAGATATGAAGATTTTGTTAATTTATAATTTATTCATGTGTTATTACTGTAATTGAAAATGTTATAGACACTTTTAAATTCAG
TTTGTGTAGAAAGAAATGTGTTAAACAAAATTATGTTAATAAATATTCCCACATAATACATCTGAATGGTTAAAAATACTGGAAGAGTTG
TCAGGGCTACAATAGTGAATGTCCTTTTTTTTAATATCAAAAATATCGATAAGTAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCA
GTGAATAGGTGGTGTACTTTACTTGGTATAATTTAAAGTTGCACAGTAAGTACTGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTA
TTTAAGAATTTGCTGTTTTATTTAACGCTGCTACTCTTAATCTTCTCTAAATTTTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTT

>92952_92952_3_TNS3-ZNRF2_TNS3_chr7_47474880_ENST00000398879_ZNRF2_chr7_30401993_ENST00000323037_length(amino acids)=206AA_BP=
MQAWQEEPEELTSSLHAFKNKAFKKSKVCGVCKQIIDGQGISCRACKYSCHKKCEAKVVIPCGVQVRLEQAPGSSTLSSSLCRDKPLRPV
ILSPTMEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMC

--------------------------------------------------------------
>92952_92952_4_TNS3-ZNRF2_TNS3_chr7_47474880_ENST00000442536_ZNRF2_chr7_30401993_ENST00000323037_length(transcript)=2429nt_BP=691nt
AGAATGGGAAACTGCCTTGGGAGAAGCCCCAAGTGAGCCCAAGGGCGCAGAGCAGAAGGACCCTGGAGTGTAAGAGCCTAGATTGCAAGC
CTGGCAGGAGGAGCCGGAAGAATTAACCTCGAGTCTGCACGCTTTTAAGAACAAGGCCTTTAAAAAATCCAAAGTGTGTGGAGTTTGCAA
ACAAATTATTGACGGTCAAGGTATTTCATGCCGAGCCTGCAAGTATTCCTGCCACAAGAAATGTGAAGCCAAGGTGGTGATTCCCTGCGG
TGTGCAAGTCCGACTGGAACAGGCTCCAGGGAGTTCCACGCTGTCCAGTTCTCTCTGCCGTGATAAACCTCTGCGGCCCGTCATCCTGAG
TCCCACCATGGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGA
GTCCTACCTGCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAG
ATATGACCTTACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATG
CAAGGCGCAGGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATA
GATCTTGCCCTGAGCACCCTTCAGATTAAGCGTCAGCTTCCTGTTTTATAGGTTTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGG
ATATGAAAATCTGTCTCTGGAGAAACAAAGACGCAGGCATACTCAGCCAGAAATCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGAC
AATCGTACTGGGGTAAAAAAACCCTGCTGAAGAGAGGACAGTGACCACAGAACTCAGTGTACCAAACATGCATACAAAGGACACACAGGG
ATTTTGAAAATGCTGCACATCCCTTAATAGTCATCTACATAGGTAATACTGATAAACATTTTGTATTCAGACGCCAAAGTTAACTGATTT
AAAAGTTGATTTACTTTTTATTAAGTTCTCCAGAGCTGCACAACTAGTTATGTTTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTG
TTTTCCCCAACATAATGTTCATAATGTTTCTGCATTCATCTGTTCTTAAATTGAAAAACATATAATTTACTTCTTATAAATTGAAGTCTT
AAATGTGAAACCAAGAAATGTAATCAAGCAGTAAAAACATCTGAATGTAGACCATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTG
GAAAATAGACTTCTACATAGGAAAGCTAAAATATGTTAATATTTTTAAATTAAAGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCA
TATTACATAATTACATTTTAATTAAATATAGAATATTCTACTGAATTGCAATTTATTAAATATTCTTATCCTCTTAAATAAAACTGCTCA
ACAGTTAATCAGCAGTGAATCATCTTGCAGCTATGCAATTTAAAAAAAATACAGATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTG
TTTTAACGGGTATCTTTTGTTTGTTCTTTTCACTTAATTATTTTATTGTGCTTTGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAAT
GTTTAGCAGGCTGTAAACTTAAGAAAAGGGTAAAATAAAATTTTCTGGAGAGGAACTTGGAATTTGAGGGAGATTTTATATACCTTTAAA
AACTGTAATTTAATTGGGATGCCAGGTTTATAGCAATTTGCAACTTTAATTTTCCAGATAATCTGGAGGTTAGCATTTGATAAATGATTT
TTTAAAGTAGATATGAAGATTTTGTTAATTTATAATTTATTCATGTGTTATTACTGTAATTGAAAATGTTATAGACACTTTTAAATTCAG
TTTGTGTAGAAAGAAATGTGTTAAACAAAATTATGTTAATAAATATTCCCACATAATACATCTGAATGGTTAAAAATACTGGAAGAGTTG
TCAGGGCTACAATAGTGAATGTCCTTTTTTTTAATATCAAAAATATCGATAAGTAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCA
GTGAATAGGTGGTGTACTTTACTTGGTATAATTTAAAGTTGCACAGTAAGTACTGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTA
TTTAAGAATTTGCTGTTTTATTTAACGCTGCTACTCTTAATCTTCTCTAAATTTTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTT

>92952_92952_4_TNS3-ZNRF2_TNS3_chr7_47474880_ENST00000442536_ZNRF2_chr7_30401993_ENST00000323037_length(amino acids)=206AA_BP=
MQAWQEEPEELTSSLHAFKNKAFKKSKVCGVCKQIIDGQGISCRACKYSCHKKCEAKVVIPCGVQVRLEQAPGSSTLSSSLCRDKPLRPV
ILSPTMEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMC

--------------------------------------------------------------
>92952_92952_5_TNS3-ZNRF2_TNS3_chr7_47474880_ENST00000458317_ZNRF2_chr7_30401993_ENST00000323037_length(transcript)=2429nt_BP=691nt
AGAATGGGAAACTGCCTTGGGAGAAGCCCCAAGTGAGCCCAAGGGCGCAGAGCAGAAGGACCCTGGAGTGTAAGAGCCTAGATTGCAAGC
CTGGCAGGAGGAGCCGGAAGAATTAACCTCGAGTCTGCACGCTTTTAAGAACAAGGCCTTTAAAAAATCCAAAGTGTGTGGAGTTTGCAA
ACAAATTATTGACGGTCAAGGTATTTCATGCCGAGCCTGCAAGTATTCCTGCCACAAGAAATGTGAAGCCAAGGTGGTGATTCCCTGCGG
TGTGCAAGTCCGACTGGAACAGGCTCCAGGGAGTTCCACGCTGTCCAGTTCTCTCTGCCGTGATAAACCTCTGCGGCCCGTCATCCTGAG
TCCCACCATGGAGGAGGGCCATGGGCTGGACCTCACTTACATCACGGAGCGCATCATCGCTGTGTCCTTCCCTGCCGGCTGCTCTGAGGA
GTCCTACCTGCACAACCTACAGGAGGTCACGCGCATGCTCAAGTCCAAGCACGGGGACAACTACCTGGTATTAAACCTTTCAGAAAAGAG
ATATGACCTTACGAAGCTTAACCCAAAGATCATGGATGTGGGCTGGCCAGAGCTCCACGCACCGCCCCTGGATAAGATGTGTACCATATG
CAAGGCGCAGGAGTCCTGGCTGAACAGCAACCTCCAGCATGTGGTCGTCATTCACTGCAGGCTGCATAGATGAATGGTTTGAAGTAAATA
GATCTTGCCCTGAGCACCCTTCAGATTAAGCGTCAGCTTCCTGTTTTATAGGTTTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGG
ATATGAAAATCTGTCTCTGGAGAAACAAAGACGCAGGCATACTCAGCCAGAAATCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGAC
AATCGTACTGGGGTAAAAAAACCCTGCTGAAGAGAGGACAGTGACCACAGAACTCAGTGTACCAAACATGCATACAAAGGACACACAGGG
ATTTTGAAAATGCTGCACATCCCTTAATAGTCATCTACATAGGTAATACTGATAAACATTTTGTATTCAGACGCCAAAGTTAACTGATTT
AAAAGTTGATTTACTTTTTATTAAGTTCTCCAGAGCTGCACAACTAGTTATGTTTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTG
TTTTCCCCAACATAATGTTCATAATGTTTCTGCATTCATCTGTTCTTAAATTGAAAAACATATAATTTACTTCTTATAAATTGAAGTCTT
AAATGTGAAACCAAGAAATGTAATCAAGCAGTAAAAACATCTGAATGTAGACCATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTG
GAAAATAGACTTCTACATAGGAAAGCTAAAATATGTTAATATTTTTAAATTAAAGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCA
TATTACATAATTACATTTTAATTAAATATAGAATATTCTACTGAATTGCAATTTATTAAATATTCTTATCCTCTTAAATAAAACTGCTCA
ACAGTTAATCAGCAGTGAATCATCTTGCAGCTATGCAATTTAAAAAAAATACAGATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTG
TTTTAACGGGTATCTTTTGTTTGTTCTTTTCACTTAATTATTTTATTGTGCTTTGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAAT
GTTTAGCAGGCTGTAAACTTAAGAAAAGGGTAAAATAAAATTTTCTGGAGAGGAACTTGGAATTTGAGGGAGATTTTATATACCTTTAAA
AACTGTAATTTAATTGGGATGCCAGGTTTATAGCAATTTGCAACTTTAATTTTCCAGATAATCTGGAGGTTAGCATTTGATAAATGATTT
TTTAAAGTAGATATGAAGATTTTGTTAATTTATAATTTATTCATGTGTTATTACTGTAATTGAAAATGTTATAGACACTTTTAAATTCAG
TTTGTGTAGAAAGAAATGTGTTAAACAAAATTATGTTAATAAATATTCCCACATAATACATCTGAATGGTTAAAAATACTGGAAGAGTTG
TCAGGGCTACAATAGTGAATGTCCTTTTTTTTAATATCAAAAATATCGATAAGTAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCA
GTGAATAGGTGGTGTACTTTACTTGGTATAATTTAAAGTTGCACAGTAAGTACTGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTA
TTTAAGAATTTGCTGTTTTATTTAACGCTGCTACTCTTAATCTTCTCTAAATTTTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTT

>92952_92952_5_TNS3-ZNRF2_TNS3_chr7_47474880_ENST00000458317_ZNRF2_chr7_30401993_ENST00000323037_length(amino acids)=206AA_BP=
MQAWQEEPEELTSSLHAFKNKAFKKSKVCGVCKQIIDGQGISCRACKYSCHKKCEAKVVIPCGVQVRLEQAPGSSTLSSSLCRDKPLRPV
ILSPTMEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TNS3-ZNRF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TNS3-ZNRF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TNS3-ZNRF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource