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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:TOP2B-NGLY1 (FusionGDB2 ID:93094) |
Fusion Gene Summary for TOP2B-NGLY1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TOP2B-NGLY1 | Fusion gene ID: 93094 | Hgene | Tgene | Gene symbol | TOP2B | NGLY1 | Gene ID | 7155 | 55768 |
| Gene name | DNA topoisomerase II beta | N-glycanase 1 | |
| Synonyms | TOPIIB|top2beta | CDDG|CDG1V|PNG-1|PNG1|PNGase | |
| Cytomap | 3p24.2 | 3p24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA topoisomerase 2-betaDNA topoisomerase II, 180 kDDNA topoisomerase II, beta isozymeU937 associated antigenantigen MLAA-44topo II betatopoisomerase (DNA) II beta 180kDatopoisomerase II betatopoisomerase IIb | peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidasehPNGasepeptide:N-glycanase | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q96IV0 | |
| Ensembl transtripts involved in fusion gene | ENST00000264331, ENST00000435706, ENST00000540199, ENST00000542520, ENST00000475717, | ENST00000422724, ENST00000280700, ENST00000396649, ENST00000417874, ENST00000428257, ENST00000467224, | |
| Fusion gene scores | * DoF score | 8 X 10 X 4=320 | 6 X 5 X 4=120 |
| # samples | 9 | 6 | |
| ** MAII score | log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TOP2B [Title/Abstract] AND NGLY1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | TOP2B(25683813)-NGLY1(25775473), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | TOP2B-NGLY1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. TOP2B-NGLY1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TOP2B | GO:0006265 | DNA topological change | 10684600 |
| Tgene | NGLY1 | GO:0006516 | glycoprotein catabolic process | 15358861 |
| Tgene | NGLY1 | GO:0006517 | protein deglycosylation | 28826503 |
| Fusion gene breakpoints across TOP2B (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across NGLY1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BLCA | TCGA-DK-A6B2-01A | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| ChimerDB4 | BLCA | TCGA-DK-A6B2-01A | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
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Fusion Gene ORF analysis for TOP2B-NGLY1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000264331 | ENST00000422724 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| 5CDS-3UTR | ENST00000264331 | ENST00000422724 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| 5CDS-3UTR | ENST00000435706 | ENST00000422724 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| 5CDS-3UTR | ENST00000435706 | ENST00000422724 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| 5CDS-3UTR | ENST00000540199 | ENST00000422724 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| 5CDS-3UTR | ENST00000542520 | ENST00000422724 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000264331 | ENST00000280700 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000264331 | ENST00000396649 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000264331 | ENST00000417874 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000264331 | ENST00000428257 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000264331 | ENST00000467224 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000435706 | ENST00000280700 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000435706 | ENST00000396649 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000435706 | ENST00000417874 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000435706 | ENST00000428257 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000435706 | ENST00000467224 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000540199 | ENST00000280700 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000540199 | ENST00000396649 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000540199 | ENST00000417874 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000540199 | ENST00000428257 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000540199 | ENST00000467224 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000542520 | ENST00000280700 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000542520 | ENST00000396649 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000542520 | ENST00000417874 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000542520 | ENST00000428257 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| Frame-shift | ENST00000542520 | ENST00000467224 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| In-frame | ENST00000264331 | ENST00000280700 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| In-frame | ENST00000264331 | ENST00000396649 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| In-frame | ENST00000264331 | ENST00000417874 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| In-frame | ENST00000264331 | ENST00000428257 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| In-frame | ENST00000264331 | ENST00000467224 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| In-frame | ENST00000435706 | ENST00000280700 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| In-frame | ENST00000435706 | ENST00000396649 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| In-frame | ENST00000435706 | ENST00000417874 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| In-frame | ENST00000435706 | ENST00000428257 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| In-frame | ENST00000435706 | ENST00000467224 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000475717 | ENST00000280700 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000475717 | ENST00000280700 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000475717 | ENST00000396649 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000475717 | ENST00000396649 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000475717 | ENST00000417874 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000475717 | ENST00000417874 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000475717 | ENST00000428257 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000475717 | ENST00000428257 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000475717 | ENST00000467224 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000475717 | ENST00000467224 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000540199 | ENST00000280700 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000540199 | ENST00000396649 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000540199 | ENST00000417874 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000540199 | ENST00000428257 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000540199 | ENST00000467224 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000542520 | ENST00000280700 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000542520 | ENST00000396649 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000542520 | ENST00000417874 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000542520 | ENST00000428257 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3CDS | ENST00000542520 | ENST00000467224 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3UTR | ENST00000475717 | ENST00000422724 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3UTR | ENST00000475717 | ENST00000422724 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3UTR | ENST00000540199 | ENST00000422724 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| intron-3UTR | ENST00000542520 | ENST00000422724 | TOP2B | chr3 | 25683813 | - | NGLY1 | chr3 | 25775473 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000435706 | TOP2B | chr3 | 25654006 | - | ENST00000428257 | NGLY1 | chr3 | 25775473 | - | 5304 | 3973 | 187 | 4788 | 1533 |
| ENST00000435706 | TOP2B | chr3 | 25654006 | - | ENST00000280700 | NGLY1 | chr3 | 25775473 | - | 5136 | 3973 | 187 | 4788 | 1533 |
| ENST00000435706 | TOP2B | chr3 | 25654006 | - | ENST00000396649 | NGLY1 | chr3 | 25775473 | - | 4800 | 3973 | 187 | 4500 | 1437 |
| ENST00000435706 | TOP2B | chr3 | 25654006 | - | ENST00000417874 | NGLY1 | chr3 | 25775473 | - | 4838 | 3973 | 187 | 4788 | 1533 |
| ENST00000435706 | TOP2B | chr3 | 25654006 | - | ENST00000467224 | NGLY1 | chr3 | 25775473 | - | 4695 | 3973 | 187 | 3978 | 1263 |
| ENST00000264331 | TOP2B | chr3 | 25654006 | - | ENST00000428257 | NGLY1 | chr3 | 25775473 | - | 5117 | 3786 | 0 | 4601 | 1533 |
| ENST00000264331 | TOP2B | chr3 | 25654006 | - | ENST00000280700 | NGLY1 | chr3 | 25775473 | - | 4949 | 3786 | 0 | 4601 | 1533 |
| ENST00000264331 | TOP2B | chr3 | 25654006 | - | ENST00000396649 | NGLY1 | chr3 | 25775473 | - | 4613 | 3786 | 0 | 4313 | 1437 |
| ENST00000264331 | TOP2B | chr3 | 25654006 | - | ENST00000417874 | NGLY1 | chr3 | 25775473 | - | 4651 | 3786 | 0 | 4601 | 1533 |
| ENST00000264331 | TOP2B | chr3 | 25654006 | - | ENST00000467224 | NGLY1 | chr3 | 25775473 | - | 4508 | 3786 | 0 | 3791 | 1263 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000435706 | ENST00000428257 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - | 0.000286979 | 0.999713 |
| ENST00000435706 | ENST00000280700 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - | 0.000308572 | 0.9996915 |
| ENST00000435706 | ENST00000396649 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - | 0.000436235 | 0.99956375 |
| ENST00000435706 | ENST00000417874 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - | 0.000366156 | 0.9996338 |
| ENST00000435706 | ENST00000467224 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - | 0.00014207 | 0.9998579 |
| ENST00000264331 | ENST00000428257 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - | 0.000228819 | 0.9997712 |
| ENST00000264331 | ENST00000280700 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - | 0.000246727 | 0.9997533 |
| ENST00000264331 | ENST00000396649 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - | 0.000346719 | 0.99965334 |
| ENST00000264331 | ENST00000417874 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - | 0.000292474 | 0.9997075 |
| ENST00000264331 | ENST00000467224 | TOP2B | chr3 | 25654006 | - | NGLY1 | chr3 | 25775473 | - | 0.000114586 | 0.99988544 |
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Fusion Genomic Features for TOP2B-NGLY1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TOP2B-NGLY1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:25683813/chr3:25775473) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | NGLY1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. {ECO:0000269|PubMed:14749736, ECO:0000269|PubMed:15358861}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000264331 | - | 28 | 36 | 476_593 | 1262 | 1627.0 | Domain | Toprim |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000435706 | - | 28 | 36 | 476_593 | 1257 | 1622.0 | Domain | Toprim |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000264331 | - | 28 | 36 | 1034_1044 | 1262 | 1627.0 | Motif | Note=Nuclear export signal |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000435706 | - | 28 | 36 | 1034_1044 | 1257 | 1622.0 | Motif | Note=Nuclear export signal |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000264331 | - | 28 | 36 | 169_171 | 1262 | 1627.0 | Nucleotide binding | ATP |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000264331 | - | 28 | 36 | 182_189 | 1262 | 1627.0 | Nucleotide binding | ATP |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000264331 | - | 28 | 36 | 397_399 | 1262 | 1627.0 | Nucleotide binding | ATP |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000435706 | - | 28 | 36 | 169_171 | 1257 | 1622.0 | Nucleotide binding | ATP |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000435706 | - | 28 | 36 | 182_189 | 1257 | 1622.0 | Nucleotide binding | ATP |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000435706 | - | 28 | 36 | 397_399 | 1257 | 1622.0 | Nucleotide binding | ATP |
| Tgene | NGLY1 | chr3:25654006 | chr3:25775473 | ENST00000280700 | 6 | 12 | 454_654 | 383 | 655.0 | Domain | PAW | |
| Tgene | NGLY1 | chr3:25654006 | chr3:25775473 | ENST00000396649 | 6 | 11 | 454_654 | 383 | 559.0 | Domain | PAW | |
| Tgene | NGLY1 | chr3:25654006 | chr3:25775473 | ENST00000417874 | 6 | 12 | 454_654 | 341 | 613.0 | Domain | PAW | |
| Tgene | NGLY1 | chr3:25654006 | chr3:25775473 | ENST00000428257 | 6 | 12 | 454_654 | 365 | 637.0 | Domain | PAW |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | NGLY1 | chr3:25654006 | chr3:25775473 | ENST00000280700 | 6 | 12 | 30_91 | 383 | 655.0 | Domain | Note=PUB | |
| Tgene | NGLY1 | chr3:25654006 | chr3:25775473 | ENST00000396649 | 6 | 11 | 30_91 | 383 | 559.0 | Domain | Note=PUB | |
| Tgene | NGLY1 | chr3:25654006 | chr3:25775473 | ENST00000417874 | 6 | 12 | 30_91 | 341 | 613.0 | Domain | Note=PUB | |
| Tgene | NGLY1 | chr3:25654006 | chr3:25775473 | ENST00000428257 | 6 | 12 | 30_91 | 365 | 637.0 | Domain | Note=PUB |
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Fusion Gene Sequence for TOP2B-NGLY1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >93094_93094_1_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000264331_NGLY1_chr3_25775473_ENST00000280700_length(transcript)=4949nt_BP=3786nt ATGGCCAAGTCGGGTGGCTGCGGCGCGGGAGCCGGCGTGGGCGGCGGCAACGGGGCACTGACCTGGGTGACTCTTTTTGATCAGAACAAT GCTGCAAAAAAAGAAGAGTCAGAAACTGCCAACAAAAATGATTCTTCAAAGAAGTTGTCTGTTGAGAGAGTGTATCAGAAGAAGACACAA CTTGAACACATTCTTCTTCGTCCTGATACATATATTGGGTCAGTGGAGCCATTGACGCAGTTCATGTGGGTGTATGATGAAGATGTAGGA ATGAATTGCAGGGAGGTTACCTTTGTGCCAGGTTTATACAAGATCTTTGATGAAATTTTGGTTAATGCTGCTGACAATAAACAGAGGGAT AAGAACATGACTTGTATTAAAGTTTCTATTGATCCTGAATCTAACATTATAAGCATTTGGAATAATGGGAAAGGCATTCCAGTAGTAGAA CACAAGGTAGAGAAAGTTTATGTTCCTGCTTTAATTTTTGGACAGCTTTTAACATCCAGTAACTATGATGATGATGAGAAAAAAGTTACA GGTGGTCGTAATGGTTATGGTGCAAAACTTTGTAATATTTTCAGTACAAAGTTTACAGTAGAAACAGCTTGCAAAGAATACAAACACAGT TTTAAGCAGACATGGATGAATAATATGATGAAGACTTCTGAAGCCAAAATTAAACATTTTGATGGTGAAGATTACACATGCATAACATTC CAACCAGATCTGTCCAAATTTAAGATGGAAAAACTTGACAAGGATATTGTGGCCCTCATGACTAGAAGGGCATATGATTTGGCTGGTTCG TGTAGAGGGGTCAAGGTCATGTTTAATGGAAAGAAATTGCCTGTAAATGGATTTCGCAGTTATGTAGATCTTTATGTGAAAGACAAATTG GATGAAACTGGGGTGGCCCTGAAAGTTATTCATGAGCTTGCAAATGAAAGATGGGATGTTTGTCTCACATTGAGTGAAAAAGGATTCCAG CAAATCAGCTTTGTAAATAGTATTGCAACTACAAAAGGTGGACGGCACGTGGATTATGTGGTAGATCAAGTTGTTGGTAAACTGATTGAA GTAGTTAAGAAAAAGAACAAAGCTGGTGTATCAGTGAAACCATTTCAAGTAAAAAACCATATATGGGTTTTTATTAATTGCCTTATTGAA AATCCAACTTTTGATTCTCAGACTAAGGAAAACATGACTCTGCAGCCCAAAAGTTTTGGGTCTAAATGCCAGCTGTCAGAAAAATTTTTT AAAGCAGCCTCTAATTGTGGCATTGTAGAAAGTATCCTGAACTGGGTGAAATTTAAGGCTCAGACTCAGCTGAATAAGAAGTGTTCATCA GTAAAATACAGTAAAATCAAAGGTATTCCCAAACTGGATGATGCTAATGATGCTGGTGGTAAACATTCCCTGGAGTGTACACTGATATTA ACAGAGGGAGACTCTGCCAAATCACTGGCTGTGTCTGGATTAGGTGTGATTGGACGAGACAGATACGGAGTTTTTCCACTCAGGGGCAAA ATTCTTAATGTACGGGAAGCTTCTCATAAACAGATCATGGAAAATGCTGAAATAAATAATATTATTAAAATAGTTGGTCTACAATATAAG AAAAGTTACGATGATGCAGAATCTCTGAAAACCTTACGCTATGGAAAGATTATGATTATGACCGATCAGGATCAAGATGGTTCTCACATA AAAGGCCTGCTTATTAATTTCATCCATCACAATTGGCCATCACTTTTGAAGCATGGTTTTCTTGAAGAGTTCATTACTCCTATTGTAAAG GCAAGCAAAAATAAGCAGGAACTTTCCTTCTACAGTATTCCTGAATTTGACGAATGGAAAAAACATATAGAAAACCAGAAAGCCTGGAAA ATAAAGTACTATAAAGGATTGGGTACTAGTACAGCTAAAGAAGCAAAGGAATATTTTGCTGATATGGAAAGGCATCGCATCTTGTTTAGA TATGCTGGTCCTGAAGATGATGCTGCCATTACCTTGGCATTTAGTAAGAAGAAGATTGATGACAGAAAAGAATGGTTAACAAATTTTATG GAAGACCGGAGACAGCGTAGGCTACATGGCTTACCAGAGCAATTTTTATATGGTACTGCAACAAAGCATTTGACTTATAATGATTTCATC AACAAGGAATTGATTCTCTTCTCAAACTCAGACAATGAAAGATCTATACCATCTCTTGTTGATGGCTTTAAACCTGGCCAGCGGAAAGTT TTATTTACCTGTTTCAAGAGGAATGATAAACGTGAAGTAAAAGTTGCCCAGTTGGCTGGCTCTGTTGCTGAGATGTCGGCTTATCATCAT GGAGAACAAGCATTGATGATGACTATTGTGAATTTGGCTCAGAACTTTGTGGGAAGTAACAACATTAACTTGCTTCAGCCTATTGGTCAG TTTGGAACTCGGCTTCATGGTGGCAAAGATGCTGCAAGCCCTCGTTATATTTTCACAATGTTAAGCACTTTAGCAAGGCTACTTTTTCCT GCTGTGGATGACAACCTCCTTAAGTTCCTTTATGATGATAATCAACGTGTAGAGCCTGAGTGGTATATTCCTATAATTCCCATGGTTTTA ATAAATGGTGCTGAGGGCATTGGTACTGGATGGGCTTGTAAACTACCCAACTATGATGCTAGGGAAATTGTGAACAATGTCAGACGAATG CTAGATGGCCTGGATCCTCATCCCATGCTTCCAAACTACAAAAACTTTAAAGGCACGATTCAAGAACTTGGTCAAAACCAGTATGCAGTC AGTGGTGAAATATTTGTAGTGGACAGAAACACAGTAGAAATTACAGAGCTTCCAGTTAGAACTTGGACACAGGTATATAAAGAACAGGTT TTAGAACCTATGCTAAATGGAACAGATAAAACACCAGCATTAATTTCTGATTATAAAGAATATCATACTGACACAACTGTGAAATTTGTG GTGAAAATGACTGAAGAGAAACTAGCACAAGCAGAAGCTGCTGGACTGCATAAAGTTTTTAAACTTCAAACTACTCTTACTTGTAATTCC ATGGTACTTTTTGATCATATGGGATGTCTGAAGAAATATGAAACTGTGCAAGACATTCTGAAAGAATTCTTTGATTTACGATTAAGTTAT TACGGTTTACGTAAGGAGTGGCTTGTGGGAATGTTGGGAGCAGAATCTACAAAGCTTAACAATCAAGCCCGTTTCATTTTAGAGAAGATA CAAGGGAAAATTACTATAGAGAATAGGTCAAAGAAAGATTTGATTCAAATGTTAGTCCAGAGAGGTTATGAATCTGACCCAGTGAAAGCC TGGAAAGAAGCACAAGAAAAGGCAGCAGAAGAGGATGAAACACAAAACCAGCATGATGATAGTTCCTCCGATTCAGGAACTCCTTCAGGC CCAGATTTTAATTATATTTTAAATATGTCTCTGTGGTCTCTTACTAAAGAAAAAGTTGAAGAACTGATTAAACAGAGAGATGCAAAAGGG CGAGAGGTCAATGATCTTAAAAGAAAATCTCCTTCAGATCTTTGGAAAGAGGATTTAGCGGCATTTGTTGAAGAACTGGATAAAGTGGAA TCTCAAGAACGAGAAGATGTTCTGGCTGGAATGTCTGGAAAAGCAATTAAAGGTAAAGTTGGCAAACCTAAGGTGAAGAAACTCCAGTTG GAAGAGACAATGCCCTCACCTTATGGCAGAAGAATAATTCCTGAAATTACAGCTATGAAGGCAGATGCCAGCAAAAAGTTGCTGAAGAAG AAGAAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATTACTTCGA GACACTATTAATGGGCTTAATAAGCAGAGGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGTGGAGCTT GTTGAATTTATATCTCCCAAAACCCCTAAACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGAA ATGGGTCTACAGAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATATTGTGAAA GATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAGAAAAGTT GAAACAGACTGGCACATGGTATATTTGGCCCGAAAGGAAGGATCATCTTTTGCTTATATTTCCTGGAAGTTTGAGTGTGGGTCAGTTGGC CTAAAAGTAGATAGCATTTCTATTAGAACAAGTAGTCAAACTTTTCAGACTGGAACAGTAGAATGGAAATTGCGATCTGATACAGCACAA GTAGAACTGACAGGCGATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGGA GATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTATAAAATTC AGTGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCATGCTTAGTT GGCAGTTACCACCCTGTGCTAGCATATTTCTTTTGCTAGCTATCCATCATGTAACCCTCATGAAAATTATCTTTATACGTGGACTATAAT AAAATATTGAATTAAAACCTTTCTTCCATATGTGACTATAATTTGGAGTAAAGTCTTGTTGACTCAATATGGGATTTTAATCTAAAACTG >93094_93094_1_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000264331_NGLY1_chr3_25775473_ENST00000280700_length(amino acids)=1533AA_BP=1262 MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGS CRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSS VKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK IKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQ FGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFV VKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKG REVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK KKVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVAWRVARGE MGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMVYLARKEGSSFAYISWKFECGSVG LKVDSISIRTSSQTFQTGTVEWKLRSDTAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEENCLEIIIKF -------------------------------------------------------------- >93094_93094_2_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000264331_NGLY1_chr3_25775473_ENST00000396649_length(transcript)=4613nt_BP=3786nt ATGGCCAAGTCGGGTGGCTGCGGCGCGGGAGCCGGCGTGGGCGGCGGCAACGGGGCACTGACCTGGGTGACTCTTTTTGATCAGAACAAT GCTGCAAAAAAAGAAGAGTCAGAAACTGCCAACAAAAATGATTCTTCAAAGAAGTTGTCTGTTGAGAGAGTGTATCAGAAGAAGACACAA CTTGAACACATTCTTCTTCGTCCTGATACATATATTGGGTCAGTGGAGCCATTGACGCAGTTCATGTGGGTGTATGATGAAGATGTAGGA ATGAATTGCAGGGAGGTTACCTTTGTGCCAGGTTTATACAAGATCTTTGATGAAATTTTGGTTAATGCTGCTGACAATAAACAGAGGGAT AAGAACATGACTTGTATTAAAGTTTCTATTGATCCTGAATCTAACATTATAAGCATTTGGAATAATGGGAAAGGCATTCCAGTAGTAGAA CACAAGGTAGAGAAAGTTTATGTTCCTGCTTTAATTTTTGGACAGCTTTTAACATCCAGTAACTATGATGATGATGAGAAAAAAGTTACA GGTGGTCGTAATGGTTATGGTGCAAAACTTTGTAATATTTTCAGTACAAAGTTTACAGTAGAAACAGCTTGCAAAGAATACAAACACAGT TTTAAGCAGACATGGATGAATAATATGATGAAGACTTCTGAAGCCAAAATTAAACATTTTGATGGTGAAGATTACACATGCATAACATTC CAACCAGATCTGTCCAAATTTAAGATGGAAAAACTTGACAAGGATATTGTGGCCCTCATGACTAGAAGGGCATATGATTTGGCTGGTTCG TGTAGAGGGGTCAAGGTCATGTTTAATGGAAAGAAATTGCCTGTAAATGGATTTCGCAGTTATGTAGATCTTTATGTGAAAGACAAATTG GATGAAACTGGGGTGGCCCTGAAAGTTATTCATGAGCTTGCAAATGAAAGATGGGATGTTTGTCTCACATTGAGTGAAAAAGGATTCCAG CAAATCAGCTTTGTAAATAGTATTGCAACTACAAAAGGTGGACGGCACGTGGATTATGTGGTAGATCAAGTTGTTGGTAAACTGATTGAA GTAGTTAAGAAAAAGAACAAAGCTGGTGTATCAGTGAAACCATTTCAAGTAAAAAACCATATATGGGTTTTTATTAATTGCCTTATTGAA AATCCAACTTTTGATTCTCAGACTAAGGAAAACATGACTCTGCAGCCCAAAAGTTTTGGGTCTAAATGCCAGCTGTCAGAAAAATTTTTT AAAGCAGCCTCTAATTGTGGCATTGTAGAAAGTATCCTGAACTGGGTGAAATTTAAGGCTCAGACTCAGCTGAATAAGAAGTGTTCATCA GTAAAATACAGTAAAATCAAAGGTATTCCCAAACTGGATGATGCTAATGATGCTGGTGGTAAACATTCCCTGGAGTGTACACTGATATTA ACAGAGGGAGACTCTGCCAAATCACTGGCTGTGTCTGGATTAGGTGTGATTGGACGAGACAGATACGGAGTTTTTCCACTCAGGGGCAAA ATTCTTAATGTACGGGAAGCTTCTCATAAACAGATCATGGAAAATGCTGAAATAAATAATATTATTAAAATAGTTGGTCTACAATATAAG AAAAGTTACGATGATGCAGAATCTCTGAAAACCTTACGCTATGGAAAGATTATGATTATGACCGATCAGGATCAAGATGGTTCTCACATA AAAGGCCTGCTTATTAATTTCATCCATCACAATTGGCCATCACTTTTGAAGCATGGTTTTCTTGAAGAGTTCATTACTCCTATTGTAAAG GCAAGCAAAAATAAGCAGGAACTTTCCTTCTACAGTATTCCTGAATTTGACGAATGGAAAAAACATATAGAAAACCAGAAAGCCTGGAAA ATAAAGTACTATAAAGGATTGGGTACTAGTACAGCTAAAGAAGCAAAGGAATATTTTGCTGATATGGAAAGGCATCGCATCTTGTTTAGA TATGCTGGTCCTGAAGATGATGCTGCCATTACCTTGGCATTTAGTAAGAAGAAGATTGATGACAGAAAAGAATGGTTAACAAATTTTATG GAAGACCGGAGACAGCGTAGGCTACATGGCTTACCAGAGCAATTTTTATATGGTACTGCAACAAAGCATTTGACTTATAATGATTTCATC AACAAGGAATTGATTCTCTTCTCAAACTCAGACAATGAAAGATCTATACCATCTCTTGTTGATGGCTTTAAACCTGGCCAGCGGAAAGTT TTATTTACCTGTTTCAAGAGGAATGATAAACGTGAAGTAAAAGTTGCCCAGTTGGCTGGCTCTGTTGCTGAGATGTCGGCTTATCATCAT GGAGAACAAGCATTGATGATGACTATTGTGAATTTGGCTCAGAACTTTGTGGGAAGTAACAACATTAACTTGCTTCAGCCTATTGGTCAG TTTGGAACTCGGCTTCATGGTGGCAAAGATGCTGCAAGCCCTCGTTATATTTTCACAATGTTAAGCACTTTAGCAAGGCTACTTTTTCCT GCTGTGGATGACAACCTCCTTAAGTTCCTTTATGATGATAATCAACGTGTAGAGCCTGAGTGGTATATTCCTATAATTCCCATGGTTTTA ATAAATGGTGCTGAGGGCATTGGTACTGGATGGGCTTGTAAACTACCCAACTATGATGCTAGGGAAATTGTGAACAATGTCAGACGAATG CTAGATGGCCTGGATCCTCATCCCATGCTTCCAAACTACAAAAACTTTAAAGGCACGATTCAAGAACTTGGTCAAAACCAGTATGCAGTC AGTGGTGAAATATTTGTAGTGGACAGAAACACAGTAGAAATTACAGAGCTTCCAGTTAGAACTTGGACACAGGTATATAAAGAACAGGTT TTAGAACCTATGCTAAATGGAACAGATAAAACACCAGCATTAATTTCTGATTATAAAGAATATCATACTGACACAACTGTGAAATTTGTG GTGAAAATGACTGAAGAGAAACTAGCACAAGCAGAAGCTGCTGGACTGCATAAAGTTTTTAAACTTCAAACTACTCTTACTTGTAATTCC ATGGTACTTTTTGATCATATGGGATGTCTGAAGAAATATGAAACTGTGCAAGACATTCTGAAAGAATTCTTTGATTTACGATTAAGTTAT TACGGTTTACGTAAGGAGTGGCTTGTGGGAATGTTGGGAGCAGAATCTACAAAGCTTAACAATCAAGCCCGTTTCATTTTAGAGAAGATA CAAGGGAAAATTACTATAGAGAATAGGTCAAAGAAAGATTTGATTCAAATGTTAGTCCAGAGAGGTTATGAATCTGACCCAGTGAAAGCC TGGAAAGAAGCACAAGAAAAGGCAGCAGAAGAGGATGAAACACAAAACCAGCATGATGATAGTTCCTCCGATTCAGGAACTCCTTCAGGC CCAGATTTTAATTATATTTTAAATATGTCTCTGTGGTCTCTTACTAAAGAAAAAGTTGAAGAACTGATTAAACAGAGAGATGCAAAAGGG CGAGAGGTCAATGATCTTAAAAGAAAATCTCCTTCAGATCTTTGGAAAGAGGATTTAGCGGCATTTGTTGAAGAACTGGATAAAGTGGAA TCTCAAGAACGAGAAGATGTTCTGGCTGGAATGTCTGGAAAAGCAATTAAAGGTAAAGTTGGCAAACCTAAGGTGAAGAAACTCCAGTTG GAAGAGACAATGCCCTCACCTTATGGCAGAAGAATAATTCCTGAAATTACAGCTATGAAGGCAGATGCCAGCAAAAAGTTGCTGAAGAAG AAGAAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATTACTTCGA GACACTATTAATGGGCTTAATAAGCAGAGGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGTGGAGCTT GTTGAATTTATATCTCCCAAAACCCCTAAACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGAA ATGGGTCTACAGAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATATTGTGAAA GATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAGAAAAGTT GAAACAGACTGGCACATGATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAG GAGATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTATAAAAT TCAGTGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCATGCTTAG TTGGCAGTTACCACCCTGTGCTAGCATATTTCTTTTGCTAGCTATCCATCATGTAACCCTCATGAAAATTATCTTTATACGTGGACTATA >93094_93094_2_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000264331_NGLY1_chr3_25775473_ENST00000396649_length(amino acids)=1437AA_BP=1262 MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGS CRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSS VKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK IKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQ FGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFV VKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKG REVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK KKVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVAWRVARGE -------------------------------------------------------------- >93094_93094_3_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000264331_NGLY1_chr3_25775473_ENST00000417874_length(transcript)=4651nt_BP=3786nt ATGGCCAAGTCGGGTGGCTGCGGCGCGGGAGCCGGCGTGGGCGGCGGCAACGGGGCACTGACCTGGGTGACTCTTTTTGATCAGAACAAT GCTGCAAAAAAAGAAGAGTCAGAAACTGCCAACAAAAATGATTCTTCAAAGAAGTTGTCTGTTGAGAGAGTGTATCAGAAGAAGACACAA CTTGAACACATTCTTCTTCGTCCTGATACATATATTGGGTCAGTGGAGCCATTGACGCAGTTCATGTGGGTGTATGATGAAGATGTAGGA ATGAATTGCAGGGAGGTTACCTTTGTGCCAGGTTTATACAAGATCTTTGATGAAATTTTGGTTAATGCTGCTGACAATAAACAGAGGGAT AAGAACATGACTTGTATTAAAGTTTCTATTGATCCTGAATCTAACATTATAAGCATTTGGAATAATGGGAAAGGCATTCCAGTAGTAGAA CACAAGGTAGAGAAAGTTTATGTTCCTGCTTTAATTTTTGGACAGCTTTTAACATCCAGTAACTATGATGATGATGAGAAAAAAGTTACA GGTGGTCGTAATGGTTATGGTGCAAAACTTTGTAATATTTTCAGTACAAAGTTTACAGTAGAAACAGCTTGCAAAGAATACAAACACAGT TTTAAGCAGACATGGATGAATAATATGATGAAGACTTCTGAAGCCAAAATTAAACATTTTGATGGTGAAGATTACACATGCATAACATTC CAACCAGATCTGTCCAAATTTAAGATGGAAAAACTTGACAAGGATATTGTGGCCCTCATGACTAGAAGGGCATATGATTTGGCTGGTTCG TGTAGAGGGGTCAAGGTCATGTTTAATGGAAAGAAATTGCCTGTAAATGGATTTCGCAGTTATGTAGATCTTTATGTGAAAGACAAATTG GATGAAACTGGGGTGGCCCTGAAAGTTATTCATGAGCTTGCAAATGAAAGATGGGATGTTTGTCTCACATTGAGTGAAAAAGGATTCCAG CAAATCAGCTTTGTAAATAGTATTGCAACTACAAAAGGTGGACGGCACGTGGATTATGTGGTAGATCAAGTTGTTGGTAAACTGATTGAA GTAGTTAAGAAAAAGAACAAAGCTGGTGTATCAGTGAAACCATTTCAAGTAAAAAACCATATATGGGTTTTTATTAATTGCCTTATTGAA AATCCAACTTTTGATTCTCAGACTAAGGAAAACATGACTCTGCAGCCCAAAAGTTTTGGGTCTAAATGCCAGCTGTCAGAAAAATTTTTT AAAGCAGCCTCTAATTGTGGCATTGTAGAAAGTATCCTGAACTGGGTGAAATTTAAGGCTCAGACTCAGCTGAATAAGAAGTGTTCATCA GTAAAATACAGTAAAATCAAAGGTATTCCCAAACTGGATGATGCTAATGATGCTGGTGGTAAACATTCCCTGGAGTGTACACTGATATTA ACAGAGGGAGACTCTGCCAAATCACTGGCTGTGTCTGGATTAGGTGTGATTGGACGAGACAGATACGGAGTTTTTCCACTCAGGGGCAAA ATTCTTAATGTACGGGAAGCTTCTCATAAACAGATCATGGAAAATGCTGAAATAAATAATATTATTAAAATAGTTGGTCTACAATATAAG AAAAGTTACGATGATGCAGAATCTCTGAAAACCTTACGCTATGGAAAGATTATGATTATGACCGATCAGGATCAAGATGGTTCTCACATA AAAGGCCTGCTTATTAATTTCATCCATCACAATTGGCCATCACTTTTGAAGCATGGTTTTCTTGAAGAGTTCATTACTCCTATTGTAAAG GCAAGCAAAAATAAGCAGGAACTTTCCTTCTACAGTATTCCTGAATTTGACGAATGGAAAAAACATATAGAAAACCAGAAAGCCTGGAAA ATAAAGTACTATAAAGGATTGGGTACTAGTACAGCTAAAGAAGCAAAGGAATATTTTGCTGATATGGAAAGGCATCGCATCTTGTTTAGA TATGCTGGTCCTGAAGATGATGCTGCCATTACCTTGGCATTTAGTAAGAAGAAGATTGATGACAGAAAAGAATGGTTAACAAATTTTATG GAAGACCGGAGACAGCGTAGGCTACATGGCTTACCAGAGCAATTTTTATATGGTACTGCAACAAAGCATTTGACTTATAATGATTTCATC AACAAGGAATTGATTCTCTTCTCAAACTCAGACAATGAAAGATCTATACCATCTCTTGTTGATGGCTTTAAACCTGGCCAGCGGAAAGTT TTATTTACCTGTTTCAAGAGGAATGATAAACGTGAAGTAAAAGTTGCCCAGTTGGCTGGCTCTGTTGCTGAGATGTCGGCTTATCATCAT GGAGAACAAGCATTGATGATGACTATTGTGAATTTGGCTCAGAACTTTGTGGGAAGTAACAACATTAACTTGCTTCAGCCTATTGGTCAG TTTGGAACTCGGCTTCATGGTGGCAAAGATGCTGCAAGCCCTCGTTATATTTTCACAATGTTAAGCACTTTAGCAAGGCTACTTTTTCCT GCTGTGGATGACAACCTCCTTAAGTTCCTTTATGATGATAATCAACGTGTAGAGCCTGAGTGGTATATTCCTATAATTCCCATGGTTTTA ATAAATGGTGCTGAGGGCATTGGTACTGGATGGGCTTGTAAACTACCCAACTATGATGCTAGGGAAATTGTGAACAATGTCAGACGAATG CTAGATGGCCTGGATCCTCATCCCATGCTTCCAAACTACAAAAACTTTAAAGGCACGATTCAAGAACTTGGTCAAAACCAGTATGCAGTC AGTGGTGAAATATTTGTAGTGGACAGAAACACAGTAGAAATTACAGAGCTTCCAGTTAGAACTTGGACACAGGTATATAAAGAACAGGTT TTAGAACCTATGCTAAATGGAACAGATAAAACACCAGCATTAATTTCTGATTATAAAGAATATCATACTGACACAACTGTGAAATTTGTG GTGAAAATGACTGAAGAGAAACTAGCACAAGCAGAAGCTGCTGGACTGCATAAAGTTTTTAAACTTCAAACTACTCTTACTTGTAATTCC ATGGTACTTTTTGATCATATGGGATGTCTGAAGAAATATGAAACTGTGCAAGACATTCTGAAAGAATTCTTTGATTTACGATTAAGTTAT TACGGTTTACGTAAGGAGTGGCTTGTGGGAATGTTGGGAGCAGAATCTACAAAGCTTAACAATCAAGCCCGTTTCATTTTAGAGAAGATA CAAGGGAAAATTACTATAGAGAATAGGTCAAAGAAAGATTTGATTCAAATGTTAGTCCAGAGAGGTTATGAATCTGACCCAGTGAAAGCC TGGAAAGAAGCACAAGAAAAGGCAGCAGAAGAGGATGAAACACAAAACCAGCATGATGATAGTTCCTCCGATTCAGGAACTCCTTCAGGC CCAGATTTTAATTATATTTTAAATATGTCTCTGTGGTCTCTTACTAAAGAAAAAGTTGAAGAACTGATTAAACAGAGAGATGCAAAAGGG CGAGAGGTCAATGATCTTAAAAGAAAATCTCCTTCAGATCTTTGGAAAGAGGATTTAGCGGCATTTGTTGAAGAACTGGATAAAGTGGAA TCTCAAGAACGAGAAGATGTTCTGGCTGGAATGTCTGGAAAAGCAATTAAAGGTAAAGTTGGCAAACCTAAGGTGAAGAAACTCCAGTTG GAAGAGACAATGCCCTCACCTTATGGCAGAAGAATAATTCCTGAAATTACAGCTATGAAGGCAGATGCCAGCAAAAAGTTGCTGAAGAAG AAGAAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATTACTTCGA GACACTATTAATGGGCTTAATAAGCAGAGGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGTGGAGCTT GTTGAATTTATATCTCCCAAAACCCCTAAACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGAA ATGGGTCTACAGAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATATTGTGAAA GATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAGAAAAGTT GAAACAGACTGGCACATGGTATATTTGGCCCGAAAGGAAGGATCATCTTTTGCTTATATTTCCTGGAAGTTTGAGTGTGGGTCAGTTGGC CTAAAAGTAGATAGCATTTCTATTAGAACAAGTAGTCAAACTTTTCAGACTGGAACAGTAGAATGGAAATTGCGATCTGATACAGCACAA GTAGAACTGACAGGCGATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGGA GATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTATAAAATTC >93094_93094_3_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000264331_NGLY1_chr3_25775473_ENST00000417874_length(amino acids)=1533AA_BP=1262 MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGS CRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSS VKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK IKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQ FGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFV VKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKG REVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK KKVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVAWRVARGE MGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMVYLARKEGSSFAYISWKFECGSVG LKVDSISIRTSSQTFQTGTVEWKLRSDTAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEENCLEIIIKF -------------------------------------------------------------- >93094_93094_4_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000264331_NGLY1_chr3_25775473_ENST00000428257_length(transcript)=5117nt_BP=3786nt ATGGCCAAGTCGGGTGGCTGCGGCGCGGGAGCCGGCGTGGGCGGCGGCAACGGGGCACTGACCTGGGTGACTCTTTTTGATCAGAACAAT GCTGCAAAAAAAGAAGAGTCAGAAACTGCCAACAAAAATGATTCTTCAAAGAAGTTGTCTGTTGAGAGAGTGTATCAGAAGAAGACACAA CTTGAACACATTCTTCTTCGTCCTGATACATATATTGGGTCAGTGGAGCCATTGACGCAGTTCATGTGGGTGTATGATGAAGATGTAGGA ATGAATTGCAGGGAGGTTACCTTTGTGCCAGGTTTATACAAGATCTTTGATGAAATTTTGGTTAATGCTGCTGACAATAAACAGAGGGAT AAGAACATGACTTGTATTAAAGTTTCTATTGATCCTGAATCTAACATTATAAGCATTTGGAATAATGGGAAAGGCATTCCAGTAGTAGAA CACAAGGTAGAGAAAGTTTATGTTCCTGCTTTAATTTTTGGACAGCTTTTAACATCCAGTAACTATGATGATGATGAGAAAAAAGTTACA GGTGGTCGTAATGGTTATGGTGCAAAACTTTGTAATATTTTCAGTACAAAGTTTACAGTAGAAACAGCTTGCAAAGAATACAAACACAGT TTTAAGCAGACATGGATGAATAATATGATGAAGACTTCTGAAGCCAAAATTAAACATTTTGATGGTGAAGATTACACATGCATAACATTC CAACCAGATCTGTCCAAATTTAAGATGGAAAAACTTGACAAGGATATTGTGGCCCTCATGACTAGAAGGGCATATGATTTGGCTGGTTCG TGTAGAGGGGTCAAGGTCATGTTTAATGGAAAGAAATTGCCTGTAAATGGATTTCGCAGTTATGTAGATCTTTATGTGAAAGACAAATTG GATGAAACTGGGGTGGCCCTGAAAGTTATTCATGAGCTTGCAAATGAAAGATGGGATGTTTGTCTCACATTGAGTGAAAAAGGATTCCAG CAAATCAGCTTTGTAAATAGTATTGCAACTACAAAAGGTGGACGGCACGTGGATTATGTGGTAGATCAAGTTGTTGGTAAACTGATTGAA GTAGTTAAGAAAAAGAACAAAGCTGGTGTATCAGTGAAACCATTTCAAGTAAAAAACCATATATGGGTTTTTATTAATTGCCTTATTGAA AATCCAACTTTTGATTCTCAGACTAAGGAAAACATGACTCTGCAGCCCAAAAGTTTTGGGTCTAAATGCCAGCTGTCAGAAAAATTTTTT AAAGCAGCCTCTAATTGTGGCATTGTAGAAAGTATCCTGAACTGGGTGAAATTTAAGGCTCAGACTCAGCTGAATAAGAAGTGTTCATCA GTAAAATACAGTAAAATCAAAGGTATTCCCAAACTGGATGATGCTAATGATGCTGGTGGTAAACATTCCCTGGAGTGTACACTGATATTA ACAGAGGGAGACTCTGCCAAATCACTGGCTGTGTCTGGATTAGGTGTGATTGGACGAGACAGATACGGAGTTTTTCCACTCAGGGGCAAA ATTCTTAATGTACGGGAAGCTTCTCATAAACAGATCATGGAAAATGCTGAAATAAATAATATTATTAAAATAGTTGGTCTACAATATAAG AAAAGTTACGATGATGCAGAATCTCTGAAAACCTTACGCTATGGAAAGATTATGATTATGACCGATCAGGATCAAGATGGTTCTCACATA AAAGGCCTGCTTATTAATTTCATCCATCACAATTGGCCATCACTTTTGAAGCATGGTTTTCTTGAAGAGTTCATTACTCCTATTGTAAAG GCAAGCAAAAATAAGCAGGAACTTTCCTTCTACAGTATTCCTGAATTTGACGAATGGAAAAAACATATAGAAAACCAGAAAGCCTGGAAA ATAAAGTACTATAAAGGATTGGGTACTAGTACAGCTAAAGAAGCAAAGGAATATTTTGCTGATATGGAAAGGCATCGCATCTTGTTTAGA TATGCTGGTCCTGAAGATGATGCTGCCATTACCTTGGCATTTAGTAAGAAGAAGATTGATGACAGAAAAGAATGGTTAACAAATTTTATG GAAGACCGGAGACAGCGTAGGCTACATGGCTTACCAGAGCAATTTTTATATGGTACTGCAACAAAGCATTTGACTTATAATGATTTCATC AACAAGGAATTGATTCTCTTCTCAAACTCAGACAATGAAAGATCTATACCATCTCTTGTTGATGGCTTTAAACCTGGCCAGCGGAAAGTT TTATTTACCTGTTTCAAGAGGAATGATAAACGTGAAGTAAAAGTTGCCCAGTTGGCTGGCTCTGTTGCTGAGATGTCGGCTTATCATCAT GGAGAACAAGCATTGATGATGACTATTGTGAATTTGGCTCAGAACTTTGTGGGAAGTAACAACATTAACTTGCTTCAGCCTATTGGTCAG TTTGGAACTCGGCTTCATGGTGGCAAAGATGCTGCAAGCCCTCGTTATATTTTCACAATGTTAAGCACTTTAGCAAGGCTACTTTTTCCT GCTGTGGATGACAACCTCCTTAAGTTCCTTTATGATGATAATCAACGTGTAGAGCCTGAGTGGTATATTCCTATAATTCCCATGGTTTTA ATAAATGGTGCTGAGGGCATTGGTACTGGATGGGCTTGTAAACTACCCAACTATGATGCTAGGGAAATTGTGAACAATGTCAGACGAATG CTAGATGGCCTGGATCCTCATCCCATGCTTCCAAACTACAAAAACTTTAAAGGCACGATTCAAGAACTTGGTCAAAACCAGTATGCAGTC AGTGGTGAAATATTTGTAGTGGACAGAAACACAGTAGAAATTACAGAGCTTCCAGTTAGAACTTGGACACAGGTATATAAAGAACAGGTT TTAGAACCTATGCTAAATGGAACAGATAAAACACCAGCATTAATTTCTGATTATAAAGAATATCATACTGACACAACTGTGAAATTTGTG GTGAAAATGACTGAAGAGAAACTAGCACAAGCAGAAGCTGCTGGACTGCATAAAGTTTTTAAACTTCAAACTACTCTTACTTGTAATTCC ATGGTACTTTTTGATCATATGGGATGTCTGAAGAAATATGAAACTGTGCAAGACATTCTGAAAGAATTCTTTGATTTACGATTAAGTTAT TACGGTTTACGTAAGGAGTGGCTTGTGGGAATGTTGGGAGCAGAATCTACAAAGCTTAACAATCAAGCCCGTTTCATTTTAGAGAAGATA CAAGGGAAAATTACTATAGAGAATAGGTCAAAGAAAGATTTGATTCAAATGTTAGTCCAGAGAGGTTATGAATCTGACCCAGTGAAAGCC TGGAAAGAAGCACAAGAAAAGGCAGCAGAAGAGGATGAAACACAAAACCAGCATGATGATAGTTCCTCCGATTCAGGAACTCCTTCAGGC CCAGATTTTAATTATATTTTAAATATGTCTCTGTGGTCTCTTACTAAAGAAAAAGTTGAAGAACTGATTAAACAGAGAGATGCAAAAGGG CGAGAGGTCAATGATCTTAAAAGAAAATCTCCTTCAGATCTTTGGAAAGAGGATTTAGCGGCATTTGTTGAAGAACTGGATAAAGTGGAA TCTCAAGAACGAGAAGATGTTCTGGCTGGAATGTCTGGAAAAGCAATTAAAGGTAAAGTTGGCAAACCTAAGGTGAAGAAACTCCAGTTG GAAGAGACAATGCCCTCACCTTATGGCAGAAGAATAATTCCTGAAATTACAGCTATGAAGGCAGATGCCAGCAAAAAGTTGCTGAAGAAG AAGAAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATTACTTCGA GACACTATTAATGGGCTTAATAAGCAGAGGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGTGGAGCTT GTTGAATTTATATCTCCCAAAACCCCTAAACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGAA ATGGGTCTACAGAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATATTGTGAAA GATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAGAAAAGTT GAAACAGACTGGCACATGGTATATTTGGCCCGAAAGGAAGGATCATCTTTTGCTTATATTTCCTGGAAGTTTGAGTGTGGGTCAGTTGGC CTAAAAGTAGATAGCATTTCTATTAGAACAAGTAGTCAAACTTTTCAGACTGGAACAGTAGAATGGAAATTGCGATCTGATACAGCACAA GTAGAACTGACAGGCGATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGGA GATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTATAAAATTC AGTGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCATGCTTAGTT GGCAGTTACCACCCTGTGCTAGCATATTTCTTTTGCTAGCTATCCATCATGTAACCCTCATGAAAATTATCTTTATACGTGGACTATAAT AAAATATTGAATTAAAACCTTTCTTCCATATGTGACTATAATTTGGAGTAAAGTCTTGTTGACTCAATATGGGATTTTAATCTAAAACTG TAAGTATGGTTTTAAAAGTTAAATAATGATATTCATGATTAAATGCTATTCATGATTATGATAAAATCTTGGGCTTATGATAGTAATTTG ACATTTTCTGATCAGCCATTCATTTCTTCAGAAGTGGTTAAATTAGAGTCTCCTAATATTTTTAATTAATGTGAAAGTACAGTAGCTCAT >93094_93094_4_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000264331_NGLY1_chr3_25775473_ENST00000428257_length(amino acids)=1533AA_BP=1262 MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGS CRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSS VKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK IKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQ FGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFV VKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKG REVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK KKVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVAWRVARGE MGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMVYLARKEGSSFAYISWKFECGSVG LKVDSISIRTSSQTFQTGTVEWKLRSDTAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEENCLEIIIKF -------------------------------------------------------------- >93094_93094_5_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000264331_NGLY1_chr3_25775473_ENST00000467224_length(transcript)=4508nt_BP=3786nt ATGGCCAAGTCGGGTGGCTGCGGCGCGGGAGCCGGCGTGGGCGGCGGCAACGGGGCACTGACCTGGGTGACTCTTTTTGATCAGAACAAT GCTGCAAAAAAAGAAGAGTCAGAAACTGCCAACAAAAATGATTCTTCAAAGAAGTTGTCTGTTGAGAGAGTGTATCAGAAGAAGACACAA CTTGAACACATTCTTCTTCGTCCTGATACATATATTGGGTCAGTGGAGCCATTGACGCAGTTCATGTGGGTGTATGATGAAGATGTAGGA ATGAATTGCAGGGAGGTTACCTTTGTGCCAGGTTTATACAAGATCTTTGATGAAATTTTGGTTAATGCTGCTGACAATAAACAGAGGGAT AAGAACATGACTTGTATTAAAGTTTCTATTGATCCTGAATCTAACATTATAAGCATTTGGAATAATGGGAAAGGCATTCCAGTAGTAGAA CACAAGGTAGAGAAAGTTTATGTTCCTGCTTTAATTTTTGGACAGCTTTTAACATCCAGTAACTATGATGATGATGAGAAAAAAGTTACA GGTGGTCGTAATGGTTATGGTGCAAAACTTTGTAATATTTTCAGTACAAAGTTTACAGTAGAAACAGCTTGCAAAGAATACAAACACAGT TTTAAGCAGACATGGATGAATAATATGATGAAGACTTCTGAAGCCAAAATTAAACATTTTGATGGTGAAGATTACACATGCATAACATTC CAACCAGATCTGTCCAAATTTAAGATGGAAAAACTTGACAAGGATATTGTGGCCCTCATGACTAGAAGGGCATATGATTTGGCTGGTTCG TGTAGAGGGGTCAAGGTCATGTTTAATGGAAAGAAATTGCCTGTAAATGGATTTCGCAGTTATGTAGATCTTTATGTGAAAGACAAATTG GATGAAACTGGGGTGGCCCTGAAAGTTATTCATGAGCTTGCAAATGAAAGATGGGATGTTTGTCTCACATTGAGTGAAAAAGGATTCCAG CAAATCAGCTTTGTAAATAGTATTGCAACTACAAAAGGTGGACGGCACGTGGATTATGTGGTAGATCAAGTTGTTGGTAAACTGATTGAA GTAGTTAAGAAAAAGAACAAAGCTGGTGTATCAGTGAAACCATTTCAAGTAAAAAACCATATATGGGTTTTTATTAATTGCCTTATTGAA AATCCAACTTTTGATTCTCAGACTAAGGAAAACATGACTCTGCAGCCCAAAAGTTTTGGGTCTAAATGCCAGCTGTCAGAAAAATTTTTT AAAGCAGCCTCTAATTGTGGCATTGTAGAAAGTATCCTGAACTGGGTGAAATTTAAGGCTCAGACTCAGCTGAATAAGAAGTGTTCATCA GTAAAATACAGTAAAATCAAAGGTATTCCCAAACTGGATGATGCTAATGATGCTGGTGGTAAACATTCCCTGGAGTGTACACTGATATTA ACAGAGGGAGACTCTGCCAAATCACTGGCTGTGTCTGGATTAGGTGTGATTGGACGAGACAGATACGGAGTTTTTCCACTCAGGGGCAAA ATTCTTAATGTACGGGAAGCTTCTCATAAACAGATCATGGAAAATGCTGAAATAAATAATATTATTAAAATAGTTGGTCTACAATATAAG AAAAGTTACGATGATGCAGAATCTCTGAAAACCTTACGCTATGGAAAGATTATGATTATGACCGATCAGGATCAAGATGGTTCTCACATA AAAGGCCTGCTTATTAATTTCATCCATCACAATTGGCCATCACTTTTGAAGCATGGTTTTCTTGAAGAGTTCATTACTCCTATTGTAAAG GCAAGCAAAAATAAGCAGGAACTTTCCTTCTACAGTATTCCTGAATTTGACGAATGGAAAAAACATATAGAAAACCAGAAAGCCTGGAAA ATAAAGTACTATAAAGGATTGGGTACTAGTACAGCTAAAGAAGCAAAGGAATATTTTGCTGATATGGAAAGGCATCGCATCTTGTTTAGA TATGCTGGTCCTGAAGATGATGCTGCCATTACCTTGGCATTTAGTAAGAAGAAGATTGATGACAGAAAAGAATGGTTAACAAATTTTATG GAAGACCGGAGACAGCGTAGGCTACATGGCTTACCAGAGCAATTTTTATATGGTACTGCAACAAAGCATTTGACTTATAATGATTTCATC AACAAGGAATTGATTCTCTTCTCAAACTCAGACAATGAAAGATCTATACCATCTCTTGTTGATGGCTTTAAACCTGGCCAGCGGAAAGTT TTATTTACCTGTTTCAAGAGGAATGATAAACGTGAAGTAAAAGTTGCCCAGTTGGCTGGCTCTGTTGCTGAGATGTCGGCTTATCATCAT GGAGAACAAGCATTGATGATGACTATTGTGAATTTGGCTCAGAACTTTGTGGGAAGTAACAACATTAACTTGCTTCAGCCTATTGGTCAG TTTGGAACTCGGCTTCATGGTGGCAAAGATGCTGCAAGCCCTCGTTATATTTTCACAATGTTAAGCACTTTAGCAAGGCTACTTTTTCCT GCTGTGGATGACAACCTCCTTAAGTTCCTTTATGATGATAATCAACGTGTAGAGCCTGAGTGGTATATTCCTATAATTCCCATGGTTTTA ATAAATGGTGCTGAGGGCATTGGTACTGGATGGGCTTGTAAACTACCCAACTATGATGCTAGGGAAATTGTGAACAATGTCAGACGAATG CTAGATGGCCTGGATCCTCATCCCATGCTTCCAAACTACAAAAACTTTAAAGGCACGATTCAAGAACTTGGTCAAAACCAGTATGCAGTC AGTGGTGAAATATTTGTAGTGGACAGAAACACAGTAGAAATTACAGAGCTTCCAGTTAGAACTTGGACACAGGTATATAAAGAACAGGTT TTAGAACCTATGCTAAATGGAACAGATAAAACACCAGCATTAATTTCTGATTATAAAGAATATCATACTGACACAACTGTGAAATTTGTG GTGAAAATGACTGAAGAGAAACTAGCACAAGCAGAAGCTGCTGGACTGCATAAAGTTTTTAAACTTCAAACTACTCTTACTTGTAATTCC ATGGTACTTTTTGATCATATGGGATGTCTGAAGAAATATGAAACTGTGCAAGACATTCTGAAAGAATTCTTTGATTTACGATTAAGTTAT TACGGTTTACGTAAGGAGTGGCTTGTGGGAATGTTGGGAGCAGAATCTACAAAGCTTAACAATCAAGCCCGTTTCATTTTAGAGAAGATA CAAGGGAAAATTACTATAGAGAATAGGTCAAAGAAAGATTTGATTCAAATGTTAGTCCAGAGAGGTTATGAATCTGACCCAGTGAAAGCC TGGAAAGAAGCACAAGAAAAGGCAGCAGAAGAGGATGAAACACAAAACCAGCATGATGATAGTTCCTCCGATTCAGGAACTCCTTCAGGC CCAGATTTTAATTATATTTTAAATATGTCTCTGTGGTCTCTTACTAAAGAAAAAGTTGAAGAACTGATTAAACAGAGAGATGCAAAAGGG CGAGAGGTCAATGATCTTAAAAGAAAATCTCCTTCAGATCTTTGGAAAGAGGATTTAGCGGCATTTGTTGAAGAACTGGATAAAGTGGAA TCTCAAGAACGAGAAGATGTTCTGGCTGGAATGTCTGGAAAAGCAATTAAAGGTAAAGTTGGCAAACCTAAGGTGAAGAAACTCCAGTTG GAAGAGACAATGCCCTCACCTTATGGCAGAAGAATAATTCCTGAAATTACAGCTATGAAGGCAGATGCCAGCAAAAAGTTGCTGAAGAAG AAGAAGAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATTACTTC GAGACACTATTAATGGGCTTAATAAGCAGAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTT GTTACAATATTGTGAAAGATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAAT CTATATTCAGAAAAGTTGAAACAGACTGGCACATGGTATATTTGGCCCGAAAGGAAGGATCATCTTTTGCTTATATTTCCTGGAAGTTTG AGTGTGGATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGGAGATGGTGAT GTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTATAAAATTCAGTGACCTT TGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCATGCTTAGTTGGCAGTTAC CACCCTGTGCTAGCATATTTCTTTTGCTAGCTATCCATCATGTAACCCTCATGAAAATTATCTTTATACGTGGACTATAATAAAATATTG >93094_93094_5_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000264331_NGLY1_chr3_25775473_ENST00000467224_length(amino acids)=1263AA_BP= MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGS CRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSS VKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK IKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQ FGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFV VKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKG REVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK -------------------------------------------------------------- >93094_93094_6_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000435706_NGLY1_chr3_25775473_ENST00000280700_length(transcript)=5136nt_BP=3973nt TTTGAGGGCAGCCGGCGGCGCGGCCTCCTCAGCGGGCTCGGCTGGACGTCCGCTCCGGATCTTCGCGATGGGGCGCGGGGGTCGGCGCGG CTAGGAGTGCGGCGAGTGGAGCGGTGGGTGCGGAGCGGCGGGGCCCAGCGGCCCGCAGGGAGGCGGGAGCGGCGGCTGCGGCCTCAGGGC CTGTGAGCTGGAGGCACTCGCCATGGCCAAGTCGGGTGGCTGCGGCGCGGGAGCCGGCGTGGGCGGCGGCAACGGGGCACTGACCTGGGT GAACAATGCTGCAAAAAAAGAAGAGTCAGAAACTGCCAACAAAAATGATTCTTCAAAGAAGTTGTCTGTTGAGAGAGTGTATCAGAAGAA GACACAACTTGAACACATTCTTCTTCGTCCTGATACATATATTGGGTCAGTGGAGCCATTGACGCAGTTCATGTGGGTGTATGATGAAGA TGTAGGAATGAATTGCAGGGAGGTTACCTTTGTGCCAGGTTTATACAAGATCTTTGATGAAATTTTGGTTAATGCTGCTGACAATAAACA GAGGGATAAGAACATGACTTGTATTAAAGTTTCTATTGATCCTGAATCTAACATTATAAGCATTTGGAATAATGGGAAAGGCATTCCAGT AGTAGAACACAAGGTAGAGAAAGTTTATGTTCCTGCTTTAATTTTTGGACAGCTTTTAACATCCAGTAACTATGATGATGATGAGAAAAA AGTTACAGGTGGTCGTAATGGTTATGGTGCAAAACTTTGTAATATTTTCAGTACAAAGTTTACAGTAGAAACAGCTTGCAAAGAATACAA ACACAGTTTTAAGCAGACATGGATGAATAATATGATGAAGACTTCTGAAGCCAAAATTAAACATTTTGATGGTGAAGATTACACATGCAT AACATTCCAACCAGATCTGTCCAAATTTAAGATGGAAAAACTTGACAAGGATATTGTGGCCCTCATGACTAGAAGGGCATATGATTTGGC TGGTTCGTGTAGAGGGGTCAAGGTCATGTTTAATGGAAAGAAATTGCCTGTAAATGGATTTCGCAGTTATGTAGATCTTTATGTGAAAGA CAAATTGGATGAAACTGGGGTGGCCCTGAAAGTTATTCATGAGCTTGCAAATGAAAGATGGGATGTTTGTCTCACATTGAGTGAAAAAGG ATTCCAGCAAATCAGCTTTGTAAATAGTATTGCAACTACAAAAGGTGGACGGCACGTGGATTATGTGGTAGATCAAGTTGTTGGTAAACT GATTGAAGTAGTTAAGAAAAAGAACAAAGCTGGTGTATCAGTGAAACCATTTCAAGTAAAAAACCATATATGGGTTTTTATTAATTGCCT TATTGAAAATCCAACTTTTGATTCTCAGACTAAGGAAAACATGACTCTGCAGCCCAAAAGTTTTGGGTCTAAATGCCAGCTGTCAGAAAA ATTTTTTAAAGCAGCCTCTAATTGTGGCATTGTAGAAAGTATCCTGAACTGGGTGAAATTTAAGGCTCAGACTCAGCTGAATAAGAAGTG TTCATCAGTAAAATACAGTAAAATCAAAGGTATTCCCAAACTGGATGATGCTAATGATGCTGGTGGTAAACATTCCCTGGAGTGTACACT GATATTAACAGAGGGAGACTCTGCCAAATCACTGGCTGTGTCTGGATTAGGTGTGATTGGACGAGACAGATACGGAGTTTTTCCACTCAG GGGCAAAATTCTTAATGTACGGGAAGCTTCTCATAAACAGATCATGGAAAATGCTGAAATAAATAATATTATTAAAATAGTTGGTCTACA ATATAAGAAAAGTTACGATGATGCAGAATCTCTGAAAACCTTACGCTATGGAAAGATTATGATTATGACCGATCAGGATCAAGATGGTTC TCACATAAAAGGCCTGCTTATTAATTTCATCCATCACAATTGGCCATCACTTTTGAAGCATGGTTTTCTTGAAGAGTTCATTACTCCTAT TGTAAAGGCAAGCAAAAATAAGCAGGAACTTTCCTTCTACAGTATTCCTGAATTTGACGAATGGAAAAAACATATAGAAAACCAGAAAGC CTGGAAAATAAAGTACTATAAAGGATTGGGTACTAGTACAGCTAAAGAAGCAAAGGAATATTTTGCTGATATGGAAAGGCATCGCATCTT GTTTAGATATGCTGGTCCTGAAGATGATGCTGCCATTACCTTGGCATTTAGTAAGAAGAAGATTGATGACAGAAAAGAATGGTTAACAAA TTTTATGGAAGACCGGAGACAGCGTAGGCTACATGGCTTACCAGAGCAATTTTTATATGGTACTGCAACAAAGCATTTGACTTATAATGA TTTCATCAACAAGGAATTGATTCTCTTCTCAAACTCAGACAATGAAAGATCTATACCATCTCTTGTTGATGGCTTTAAACCTGGCCAGCG GAAAGTTTTATTTACCTGTTTCAAGAGGAATGATAAACGTGAAGTAAAAGTTGCCCAGTTGGCTGGCTCTGTTGCTGAGATGTCGGCTTA TCATCATGGAGAACAAGCATTGATGATGACTATTGTGAATTTGGCTCAGAACTTTGTGGGAAGTAACAACATTAACTTGCTTCAGCCTAT TGGTCAGTTTGGAACTCGGCTTCATGGTGGCAAAGATGCTGCAAGCCCTCGTTATATTTTCACAATGTTAAGCACTTTAGCAAGGCTACT TTTTCCTGCTGTGGATGACAACCTCCTTAAGTTCCTTTATGATGATAATCAACGTGTAGAGCCTGAGTGGTATATTCCTATAATTCCCAT GGTTTTAATAAATGGTGCTGAGGGCATTGGTACTGGATGGGCTTGTAAACTACCCAACTATGATGCTAGGGAAATTGTGAACAATGTCAG ACGAATGCTAGATGGCCTGGATCCTCATCCCATGCTTCCAAACTACAAAAACTTTAAAGGCACGATTCAAGAACTTGGTCAAAACCAGTA TGCAGTCAGTGGTGAAATATTTGTAGTGGACAGAAACACAGTAGAAATTACAGAGCTTCCAGTTAGAACTTGGACACAGGTATATAAAGA ACAGGTTTTAGAACCTATGCTAAATGGAACAGATAAAACACCAGCATTAATTTCTGATTATAAAGAATATCATACTGACACAACTGTGAA ATTTGTGGTGAAAATGACTGAAGAGAAACTAGCACAAGCAGAAGCTGCTGGACTGCATAAAGTTTTTAAACTTCAAACTACTCTTACTTG TAATTCCATGGTACTTTTTGATCATATGGGATGTCTGAAGAAATATGAAACTGTGCAAGACATTCTGAAAGAATTCTTTGATTTACGATT AAGTTATTACGGTTTACGTAAGGAGTGGCTTGTGGGAATGTTGGGAGCAGAATCTACAAAGCTTAACAATCAAGCCCGTTTCATTTTAGA GAAGATACAAGGGAAAATTACTATAGAGAATAGGTCAAAGAAAGATTTGATTCAAATGTTAGTCCAGAGAGGTTATGAATCTGACCCAGT GAAAGCCTGGAAAGAAGCACAAGAAAAGGCAGCAGAAGAGGATGAAACACAAAACCAGCATGATGATAGTTCCTCCGATTCAGGAACTCC TTCAGGCCCAGATTTTAATTATATTTTAAATATGTCTCTGTGGTCTCTTACTAAAGAAAAAGTTGAAGAACTGATTAAACAGAGAGATGC AAAAGGGCGAGAGGTCAATGATCTTAAAAGAAAATCTCCTTCAGATCTTTGGAAAGAGGATTTAGCGGCATTTGTTGAAGAACTGGATAA AGTGGAATCTCAAGAACGAGAAGATGTTCTGGCTGGAATGTCTGGAAAAGCAATTAAAGGTAAAGTTGGCAAACCTAAGGTGAAGAAACT CCAGTTGGAAGAGACAATGCCCTCACCTTATGGCAGAAGAATAATTCCTGAAATTACAGCTATGAAGGCAGATGCCAGCAAAAAGTTGCT GAAGAAGAAGAAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATT ACTTCGAGACACTATTAATGGGCTTAATAAGCAGAGGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGT GGAGCTTGTTGAATTTATATCTCCCAAAACCCCTAAACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCG AGGTGAAATGGGTCTACAGAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATAT TGTGAAAGATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAG AAAAGTTGAAACAGACTGGCACATGGTATATTTGGCCCGAAAGGAAGGATCATCTTTTGCTTATATTTCCTGGAAGTTTGAGTGTGGGTC AGTTGGCCTAAAAGTAGATAGCATTTCTATTAGAACAAGTAGTCAAACTTTTCAGACTGGAACAGTAGAATGGAAATTGCGATCTGATAC AGCACAAGTAGAACTGACAGGCGATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAG CAGAGGAGATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTAT AAAATTCAGTGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCATG CTTAGTTGGCAGTTACCACCCTGTGCTAGCATATTTCTTTTGCTAGCTATCCATCATGTAACCCTCATGAAAATTATCTTTATACGTGGA CTATAATAAAATATTGAATTAAAACCTTTCTTCCATATGTGACTATAATTTGGAGTAAAGTCTTGTTGACTCAATATGGGATTTTAATCT AAAACTGTAAGTATGGTTTTAAAAGTTAAATAATGATATTCATGATTAAATGCTATTCATGATTATGATAAAATCTTGGGCTTATGATAG >93094_93094_6_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000435706_NGLY1_chr3_25775473_ENST00000280700_length(amino acids)=1533AA_BP=1262 MEALAMAKSGGCGAGAGVGGGNGALTWVNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGS CRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSS VKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK IKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQ FGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFV VKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKG REVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK KKVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVAWRVARGE MGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMVYLARKEGSSFAYISWKFECGSVG LKVDSISIRTSSQTFQTGTVEWKLRSDTAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEENCLEIIIKF -------------------------------------------------------------- >93094_93094_7_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000435706_NGLY1_chr3_25775473_ENST00000396649_length(transcript)=4800nt_BP=3973nt TTTGAGGGCAGCCGGCGGCGCGGCCTCCTCAGCGGGCTCGGCTGGACGTCCGCTCCGGATCTTCGCGATGGGGCGCGGGGGTCGGCGCGG CTAGGAGTGCGGCGAGTGGAGCGGTGGGTGCGGAGCGGCGGGGCCCAGCGGCCCGCAGGGAGGCGGGAGCGGCGGCTGCGGCCTCAGGGC CTGTGAGCTGGAGGCACTCGCCATGGCCAAGTCGGGTGGCTGCGGCGCGGGAGCCGGCGTGGGCGGCGGCAACGGGGCACTGACCTGGGT GAACAATGCTGCAAAAAAAGAAGAGTCAGAAACTGCCAACAAAAATGATTCTTCAAAGAAGTTGTCTGTTGAGAGAGTGTATCAGAAGAA GACACAACTTGAACACATTCTTCTTCGTCCTGATACATATATTGGGTCAGTGGAGCCATTGACGCAGTTCATGTGGGTGTATGATGAAGA TGTAGGAATGAATTGCAGGGAGGTTACCTTTGTGCCAGGTTTATACAAGATCTTTGATGAAATTTTGGTTAATGCTGCTGACAATAAACA GAGGGATAAGAACATGACTTGTATTAAAGTTTCTATTGATCCTGAATCTAACATTATAAGCATTTGGAATAATGGGAAAGGCATTCCAGT AGTAGAACACAAGGTAGAGAAAGTTTATGTTCCTGCTTTAATTTTTGGACAGCTTTTAACATCCAGTAACTATGATGATGATGAGAAAAA AGTTACAGGTGGTCGTAATGGTTATGGTGCAAAACTTTGTAATATTTTCAGTACAAAGTTTACAGTAGAAACAGCTTGCAAAGAATACAA ACACAGTTTTAAGCAGACATGGATGAATAATATGATGAAGACTTCTGAAGCCAAAATTAAACATTTTGATGGTGAAGATTACACATGCAT AACATTCCAACCAGATCTGTCCAAATTTAAGATGGAAAAACTTGACAAGGATATTGTGGCCCTCATGACTAGAAGGGCATATGATTTGGC TGGTTCGTGTAGAGGGGTCAAGGTCATGTTTAATGGAAAGAAATTGCCTGTAAATGGATTTCGCAGTTATGTAGATCTTTATGTGAAAGA CAAATTGGATGAAACTGGGGTGGCCCTGAAAGTTATTCATGAGCTTGCAAATGAAAGATGGGATGTTTGTCTCACATTGAGTGAAAAAGG ATTCCAGCAAATCAGCTTTGTAAATAGTATTGCAACTACAAAAGGTGGACGGCACGTGGATTATGTGGTAGATCAAGTTGTTGGTAAACT GATTGAAGTAGTTAAGAAAAAGAACAAAGCTGGTGTATCAGTGAAACCATTTCAAGTAAAAAACCATATATGGGTTTTTATTAATTGCCT TATTGAAAATCCAACTTTTGATTCTCAGACTAAGGAAAACATGACTCTGCAGCCCAAAAGTTTTGGGTCTAAATGCCAGCTGTCAGAAAA ATTTTTTAAAGCAGCCTCTAATTGTGGCATTGTAGAAAGTATCCTGAACTGGGTGAAATTTAAGGCTCAGACTCAGCTGAATAAGAAGTG TTCATCAGTAAAATACAGTAAAATCAAAGGTATTCCCAAACTGGATGATGCTAATGATGCTGGTGGTAAACATTCCCTGGAGTGTACACT GATATTAACAGAGGGAGACTCTGCCAAATCACTGGCTGTGTCTGGATTAGGTGTGATTGGACGAGACAGATACGGAGTTTTTCCACTCAG GGGCAAAATTCTTAATGTACGGGAAGCTTCTCATAAACAGATCATGGAAAATGCTGAAATAAATAATATTATTAAAATAGTTGGTCTACA ATATAAGAAAAGTTACGATGATGCAGAATCTCTGAAAACCTTACGCTATGGAAAGATTATGATTATGACCGATCAGGATCAAGATGGTTC TCACATAAAAGGCCTGCTTATTAATTTCATCCATCACAATTGGCCATCACTTTTGAAGCATGGTTTTCTTGAAGAGTTCATTACTCCTAT TGTAAAGGCAAGCAAAAATAAGCAGGAACTTTCCTTCTACAGTATTCCTGAATTTGACGAATGGAAAAAACATATAGAAAACCAGAAAGC CTGGAAAATAAAGTACTATAAAGGATTGGGTACTAGTACAGCTAAAGAAGCAAAGGAATATTTTGCTGATATGGAAAGGCATCGCATCTT GTTTAGATATGCTGGTCCTGAAGATGATGCTGCCATTACCTTGGCATTTAGTAAGAAGAAGATTGATGACAGAAAAGAATGGTTAACAAA TTTTATGGAAGACCGGAGACAGCGTAGGCTACATGGCTTACCAGAGCAATTTTTATATGGTACTGCAACAAAGCATTTGACTTATAATGA TTTCATCAACAAGGAATTGATTCTCTTCTCAAACTCAGACAATGAAAGATCTATACCATCTCTTGTTGATGGCTTTAAACCTGGCCAGCG GAAAGTTTTATTTACCTGTTTCAAGAGGAATGATAAACGTGAAGTAAAAGTTGCCCAGTTGGCTGGCTCTGTTGCTGAGATGTCGGCTTA TCATCATGGAGAACAAGCATTGATGATGACTATTGTGAATTTGGCTCAGAACTTTGTGGGAAGTAACAACATTAACTTGCTTCAGCCTAT TGGTCAGTTTGGAACTCGGCTTCATGGTGGCAAAGATGCTGCAAGCCCTCGTTATATTTTCACAATGTTAAGCACTTTAGCAAGGCTACT TTTTCCTGCTGTGGATGACAACCTCCTTAAGTTCCTTTATGATGATAATCAACGTGTAGAGCCTGAGTGGTATATTCCTATAATTCCCAT GGTTTTAATAAATGGTGCTGAGGGCATTGGTACTGGATGGGCTTGTAAACTACCCAACTATGATGCTAGGGAAATTGTGAACAATGTCAG ACGAATGCTAGATGGCCTGGATCCTCATCCCATGCTTCCAAACTACAAAAACTTTAAAGGCACGATTCAAGAACTTGGTCAAAACCAGTA TGCAGTCAGTGGTGAAATATTTGTAGTGGACAGAAACACAGTAGAAATTACAGAGCTTCCAGTTAGAACTTGGACACAGGTATATAAAGA ACAGGTTTTAGAACCTATGCTAAATGGAACAGATAAAACACCAGCATTAATTTCTGATTATAAAGAATATCATACTGACACAACTGTGAA ATTTGTGGTGAAAATGACTGAAGAGAAACTAGCACAAGCAGAAGCTGCTGGACTGCATAAAGTTTTTAAACTTCAAACTACTCTTACTTG TAATTCCATGGTACTTTTTGATCATATGGGATGTCTGAAGAAATATGAAACTGTGCAAGACATTCTGAAAGAATTCTTTGATTTACGATT AAGTTATTACGGTTTACGTAAGGAGTGGCTTGTGGGAATGTTGGGAGCAGAATCTACAAAGCTTAACAATCAAGCCCGTTTCATTTTAGA GAAGATACAAGGGAAAATTACTATAGAGAATAGGTCAAAGAAAGATTTGATTCAAATGTTAGTCCAGAGAGGTTATGAATCTGACCCAGT GAAAGCCTGGAAAGAAGCACAAGAAAAGGCAGCAGAAGAGGATGAAACACAAAACCAGCATGATGATAGTTCCTCCGATTCAGGAACTCC TTCAGGCCCAGATTTTAATTATATTTTAAATATGTCTCTGTGGTCTCTTACTAAAGAAAAAGTTGAAGAACTGATTAAACAGAGAGATGC AAAAGGGCGAGAGGTCAATGATCTTAAAAGAAAATCTCCTTCAGATCTTTGGAAAGAGGATTTAGCGGCATTTGTTGAAGAACTGGATAA AGTGGAATCTCAAGAACGAGAAGATGTTCTGGCTGGAATGTCTGGAAAAGCAATTAAAGGTAAAGTTGGCAAACCTAAGGTGAAGAAACT CCAGTTGGAAGAGACAATGCCCTCACCTTATGGCAGAAGAATAATTCCTGAAATTACAGCTATGAAGGCAGATGCCAGCAAAAAGTTGCT GAAGAAGAAGAAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATT ACTTCGAGACACTATTAATGGGCTTAATAAGCAGAGGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGT GGAGCTTGTTGAATTTATATCTCCCAAAACCCCTAAACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCG AGGTGAAATGGGTCTACAGAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATAT TGTGAAAGATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAG AAAAGTTGAAACAGACTGGCACATGATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTA AGCAGAGGAGATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATT ATAAAATTCAGTGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCA TGCTTAGTTGGCAGTTACCACCCTGTGCTAGCATATTTCTTTTGCTAGCTATCCATCATGTAACCCTCATGAAAATTATCTTTATACGTG >93094_93094_7_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000435706_NGLY1_chr3_25775473_ENST00000396649_length(amino acids)=1437AA_BP=1262 MEALAMAKSGGCGAGAGVGGGNGALTWVNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGS CRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSS VKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK IKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQ FGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFV VKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKG REVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK KKVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVAWRVARGE -------------------------------------------------------------- >93094_93094_8_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000435706_NGLY1_chr3_25775473_ENST00000417874_length(transcript)=4838nt_BP=3973nt TTTGAGGGCAGCCGGCGGCGCGGCCTCCTCAGCGGGCTCGGCTGGACGTCCGCTCCGGATCTTCGCGATGGGGCGCGGGGGTCGGCGCGG CTAGGAGTGCGGCGAGTGGAGCGGTGGGTGCGGAGCGGCGGGGCCCAGCGGCCCGCAGGGAGGCGGGAGCGGCGGCTGCGGCCTCAGGGC CTGTGAGCTGGAGGCACTCGCCATGGCCAAGTCGGGTGGCTGCGGCGCGGGAGCCGGCGTGGGCGGCGGCAACGGGGCACTGACCTGGGT GAACAATGCTGCAAAAAAAGAAGAGTCAGAAACTGCCAACAAAAATGATTCTTCAAAGAAGTTGTCTGTTGAGAGAGTGTATCAGAAGAA GACACAACTTGAACACATTCTTCTTCGTCCTGATACATATATTGGGTCAGTGGAGCCATTGACGCAGTTCATGTGGGTGTATGATGAAGA TGTAGGAATGAATTGCAGGGAGGTTACCTTTGTGCCAGGTTTATACAAGATCTTTGATGAAATTTTGGTTAATGCTGCTGACAATAAACA GAGGGATAAGAACATGACTTGTATTAAAGTTTCTATTGATCCTGAATCTAACATTATAAGCATTTGGAATAATGGGAAAGGCATTCCAGT AGTAGAACACAAGGTAGAGAAAGTTTATGTTCCTGCTTTAATTTTTGGACAGCTTTTAACATCCAGTAACTATGATGATGATGAGAAAAA AGTTACAGGTGGTCGTAATGGTTATGGTGCAAAACTTTGTAATATTTTCAGTACAAAGTTTACAGTAGAAACAGCTTGCAAAGAATACAA ACACAGTTTTAAGCAGACATGGATGAATAATATGATGAAGACTTCTGAAGCCAAAATTAAACATTTTGATGGTGAAGATTACACATGCAT AACATTCCAACCAGATCTGTCCAAATTTAAGATGGAAAAACTTGACAAGGATATTGTGGCCCTCATGACTAGAAGGGCATATGATTTGGC TGGTTCGTGTAGAGGGGTCAAGGTCATGTTTAATGGAAAGAAATTGCCTGTAAATGGATTTCGCAGTTATGTAGATCTTTATGTGAAAGA CAAATTGGATGAAACTGGGGTGGCCCTGAAAGTTATTCATGAGCTTGCAAATGAAAGATGGGATGTTTGTCTCACATTGAGTGAAAAAGG ATTCCAGCAAATCAGCTTTGTAAATAGTATTGCAACTACAAAAGGTGGACGGCACGTGGATTATGTGGTAGATCAAGTTGTTGGTAAACT GATTGAAGTAGTTAAGAAAAAGAACAAAGCTGGTGTATCAGTGAAACCATTTCAAGTAAAAAACCATATATGGGTTTTTATTAATTGCCT TATTGAAAATCCAACTTTTGATTCTCAGACTAAGGAAAACATGACTCTGCAGCCCAAAAGTTTTGGGTCTAAATGCCAGCTGTCAGAAAA ATTTTTTAAAGCAGCCTCTAATTGTGGCATTGTAGAAAGTATCCTGAACTGGGTGAAATTTAAGGCTCAGACTCAGCTGAATAAGAAGTG TTCATCAGTAAAATACAGTAAAATCAAAGGTATTCCCAAACTGGATGATGCTAATGATGCTGGTGGTAAACATTCCCTGGAGTGTACACT GATATTAACAGAGGGAGACTCTGCCAAATCACTGGCTGTGTCTGGATTAGGTGTGATTGGACGAGACAGATACGGAGTTTTTCCACTCAG GGGCAAAATTCTTAATGTACGGGAAGCTTCTCATAAACAGATCATGGAAAATGCTGAAATAAATAATATTATTAAAATAGTTGGTCTACA ATATAAGAAAAGTTACGATGATGCAGAATCTCTGAAAACCTTACGCTATGGAAAGATTATGATTATGACCGATCAGGATCAAGATGGTTC TCACATAAAAGGCCTGCTTATTAATTTCATCCATCACAATTGGCCATCACTTTTGAAGCATGGTTTTCTTGAAGAGTTCATTACTCCTAT TGTAAAGGCAAGCAAAAATAAGCAGGAACTTTCCTTCTACAGTATTCCTGAATTTGACGAATGGAAAAAACATATAGAAAACCAGAAAGC CTGGAAAATAAAGTACTATAAAGGATTGGGTACTAGTACAGCTAAAGAAGCAAAGGAATATTTTGCTGATATGGAAAGGCATCGCATCTT GTTTAGATATGCTGGTCCTGAAGATGATGCTGCCATTACCTTGGCATTTAGTAAGAAGAAGATTGATGACAGAAAAGAATGGTTAACAAA TTTTATGGAAGACCGGAGACAGCGTAGGCTACATGGCTTACCAGAGCAATTTTTATATGGTACTGCAACAAAGCATTTGACTTATAATGA TTTCATCAACAAGGAATTGATTCTCTTCTCAAACTCAGACAATGAAAGATCTATACCATCTCTTGTTGATGGCTTTAAACCTGGCCAGCG GAAAGTTTTATTTACCTGTTTCAAGAGGAATGATAAACGTGAAGTAAAAGTTGCCCAGTTGGCTGGCTCTGTTGCTGAGATGTCGGCTTA TCATCATGGAGAACAAGCATTGATGATGACTATTGTGAATTTGGCTCAGAACTTTGTGGGAAGTAACAACATTAACTTGCTTCAGCCTAT TGGTCAGTTTGGAACTCGGCTTCATGGTGGCAAAGATGCTGCAAGCCCTCGTTATATTTTCACAATGTTAAGCACTTTAGCAAGGCTACT TTTTCCTGCTGTGGATGACAACCTCCTTAAGTTCCTTTATGATGATAATCAACGTGTAGAGCCTGAGTGGTATATTCCTATAATTCCCAT GGTTTTAATAAATGGTGCTGAGGGCATTGGTACTGGATGGGCTTGTAAACTACCCAACTATGATGCTAGGGAAATTGTGAACAATGTCAG ACGAATGCTAGATGGCCTGGATCCTCATCCCATGCTTCCAAACTACAAAAACTTTAAAGGCACGATTCAAGAACTTGGTCAAAACCAGTA TGCAGTCAGTGGTGAAATATTTGTAGTGGACAGAAACACAGTAGAAATTACAGAGCTTCCAGTTAGAACTTGGACACAGGTATATAAAGA ACAGGTTTTAGAACCTATGCTAAATGGAACAGATAAAACACCAGCATTAATTTCTGATTATAAAGAATATCATACTGACACAACTGTGAA ATTTGTGGTGAAAATGACTGAAGAGAAACTAGCACAAGCAGAAGCTGCTGGACTGCATAAAGTTTTTAAACTTCAAACTACTCTTACTTG TAATTCCATGGTACTTTTTGATCATATGGGATGTCTGAAGAAATATGAAACTGTGCAAGACATTCTGAAAGAATTCTTTGATTTACGATT AAGTTATTACGGTTTACGTAAGGAGTGGCTTGTGGGAATGTTGGGAGCAGAATCTACAAAGCTTAACAATCAAGCCCGTTTCATTTTAGA GAAGATACAAGGGAAAATTACTATAGAGAATAGGTCAAAGAAAGATTTGATTCAAATGTTAGTCCAGAGAGGTTATGAATCTGACCCAGT GAAAGCCTGGAAAGAAGCACAAGAAAAGGCAGCAGAAGAGGATGAAACACAAAACCAGCATGATGATAGTTCCTCCGATTCAGGAACTCC TTCAGGCCCAGATTTTAATTATATTTTAAATATGTCTCTGTGGTCTCTTACTAAAGAAAAAGTTGAAGAACTGATTAAACAGAGAGATGC AAAAGGGCGAGAGGTCAATGATCTTAAAAGAAAATCTCCTTCAGATCTTTGGAAAGAGGATTTAGCGGCATTTGTTGAAGAACTGGATAA AGTGGAATCTCAAGAACGAGAAGATGTTCTGGCTGGAATGTCTGGAAAAGCAATTAAAGGTAAAGTTGGCAAACCTAAGGTGAAGAAACT CCAGTTGGAAGAGACAATGCCCTCACCTTATGGCAGAAGAATAATTCCTGAAATTACAGCTATGAAGGCAGATGCCAGCAAAAAGTTGCT GAAGAAGAAGAAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATT ACTTCGAGACACTATTAATGGGCTTAATAAGCAGAGGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGT GGAGCTTGTTGAATTTATATCTCCCAAAACCCCTAAACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCG AGGTGAAATGGGTCTACAGAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATAT TGTGAAAGATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAG AAAAGTTGAAACAGACTGGCACATGGTATATTTGGCCCGAAAGGAAGGATCATCTTTTGCTTATATTTCCTGGAAGTTTGAGTGTGGGTC AGTTGGCCTAAAAGTAGATAGCATTTCTATTAGAACAAGTAGTCAAACTTTTCAGACTGGAACAGTAGAATGGAAATTGCGATCTGATAC AGCACAAGTAGAACTGACAGGCGATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAG CAGAGGAGATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTAT >93094_93094_8_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000435706_NGLY1_chr3_25775473_ENST00000417874_length(amino acids)=1533AA_BP=1262 MEALAMAKSGGCGAGAGVGGGNGALTWVNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGS CRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSS VKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK IKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQ FGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFV VKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKG REVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK KKVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVAWRVARGE MGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMVYLARKEGSSFAYISWKFECGSVG LKVDSISIRTSSQTFQTGTVEWKLRSDTAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEENCLEIIIKF -------------------------------------------------------------- >93094_93094_9_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000435706_NGLY1_chr3_25775473_ENST00000428257_length(transcript)=5304nt_BP=3973nt TTTGAGGGCAGCCGGCGGCGCGGCCTCCTCAGCGGGCTCGGCTGGACGTCCGCTCCGGATCTTCGCGATGGGGCGCGGGGGTCGGCGCGG CTAGGAGTGCGGCGAGTGGAGCGGTGGGTGCGGAGCGGCGGGGCCCAGCGGCCCGCAGGGAGGCGGGAGCGGCGGCTGCGGCCTCAGGGC CTGTGAGCTGGAGGCACTCGCCATGGCCAAGTCGGGTGGCTGCGGCGCGGGAGCCGGCGTGGGCGGCGGCAACGGGGCACTGACCTGGGT GAACAATGCTGCAAAAAAAGAAGAGTCAGAAACTGCCAACAAAAATGATTCTTCAAAGAAGTTGTCTGTTGAGAGAGTGTATCAGAAGAA GACACAACTTGAACACATTCTTCTTCGTCCTGATACATATATTGGGTCAGTGGAGCCATTGACGCAGTTCATGTGGGTGTATGATGAAGA TGTAGGAATGAATTGCAGGGAGGTTACCTTTGTGCCAGGTTTATACAAGATCTTTGATGAAATTTTGGTTAATGCTGCTGACAATAAACA GAGGGATAAGAACATGACTTGTATTAAAGTTTCTATTGATCCTGAATCTAACATTATAAGCATTTGGAATAATGGGAAAGGCATTCCAGT AGTAGAACACAAGGTAGAGAAAGTTTATGTTCCTGCTTTAATTTTTGGACAGCTTTTAACATCCAGTAACTATGATGATGATGAGAAAAA AGTTACAGGTGGTCGTAATGGTTATGGTGCAAAACTTTGTAATATTTTCAGTACAAAGTTTACAGTAGAAACAGCTTGCAAAGAATACAA ACACAGTTTTAAGCAGACATGGATGAATAATATGATGAAGACTTCTGAAGCCAAAATTAAACATTTTGATGGTGAAGATTACACATGCAT AACATTCCAACCAGATCTGTCCAAATTTAAGATGGAAAAACTTGACAAGGATATTGTGGCCCTCATGACTAGAAGGGCATATGATTTGGC TGGTTCGTGTAGAGGGGTCAAGGTCATGTTTAATGGAAAGAAATTGCCTGTAAATGGATTTCGCAGTTATGTAGATCTTTATGTGAAAGA CAAATTGGATGAAACTGGGGTGGCCCTGAAAGTTATTCATGAGCTTGCAAATGAAAGATGGGATGTTTGTCTCACATTGAGTGAAAAAGG ATTCCAGCAAATCAGCTTTGTAAATAGTATTGCAACTACAAAAGGTGGACGGCACGTGGATTATGTGGTAGATCAAGTTGTTGGTAAACT GATTGAAGTAGTTAAGAAAAAGAACAAAGCTGGTGTATCAGTGAAACCATTTCAAGTAAAAAACCATATATGGGTTTTTATTAATTGCCT TATTGAAAATCCAACTTTTGATTCTCAGACTAAGGAAAACATGACTCTGCAGCCCAAAAGTTTTGGGTCTAAATGCCAGCTGTCAGAAAA ATTTTTTAAAGCAGCCTCTAATTGTGGCATTGTAGAAAGTATCCTGAACTGGGTGAAATTTAAGGCTCAGACTCAGCTGAATAAGAAGTG TTCATCAGTAAAATACAGTAAAATCAAAGGTATTCCCAAACTGGATGATGCTAATGATGCTGGTGGTAAACATTCCCTGGAGTGTACACT GATATTAACAGAGGGAGACTCTGCCAAATCACTGGCTGTGTCTGGATTAGGTGTGATTGGACGAGACAGATACGGAGTTTTTCCACTCAG GGGCAAAATTCTTAATGTACGGGAAGCTTCTCATAAACAGATCATGGAAAATGCTGAAATAAATAATATTATTAAAATAGTTGGTCTACA ATATAAGAAAAGTTACGATGATGCAGAATCTCTGAAAACCTTACGCTATGGAAAGATTATGATTATGACCGATCAGGATCAAGATGGTTC TCACATAAAAGGCCTGCTTATTAATTTCATCCATCACAATTGGCCATCACTTTTGAAGCATGGTTTTCTTGAAGAGTTCATTACTCCTAT TGTAAAGGCAAGCAAAAATAAGCAGGAACTTTCCTTCTACAGTATTCCTGAATTTGACGAATGGAAAAAACATATAGAAAACCAGAAAGC CTGGAAAATAAAGTACTATAAAGGATTGGGTACTAGTACAGCTAAAGAAGCAAAGGAATATTTTGCTGATATGGAAAGGCATCGCATCTT GTTTAGATATGCTGGTCCTGAAGATGATGCTGCCATTACCTTGGCATTTAGTAAGAAGAAGATTGATGACAGAAAAGAATGGTTAACAAA TTTTATGGAAGACCGGAGACAGCGTAGGCTACATGGCTTACCAGAGCAATTTTTATATGGTACTGCAACAAAGCATTTGACTTATAATGA TTTCATCAACAAGGAATTGATTCTCTTCTCAAACTCAGACAATGAAAGATCTATACCATCTCTTGTTGATGGCTTTAAACCTGGCCAGCG GAAAGTTTTATTTACCTGTTTCAAGAGGAATGATAAACGTGAAGTAAAAGTTGCCCAGTTGGCTGGCTCTGTTGCTGAGATGTCGGCTTA TCATCATGGAGAACAAGCATTGATGATGACTATTGTGAATTTGGCTCAGAACTTTGTGGGAAGTAACAACATTAACTTGCTTCAGCCTAT TGGTCAGTTTGGAACTCGGCTTCATGGTGGCAAAGATGCTGCAAGCCCTCGTTATATTTTCACAATGTTAAGCACTTTAGCAAGGCTACT TTTTCCTGCTGTGGATGACAACCTCCTTAAGTTCCTTTATGATGATAATCAACGTGTAGAGCCTGAGTGGTATATTCCTATAATTCCCAT GGTTTTAATAAATGGTGCTGAGGGCATTGGTACTGGATGGGCTTGTAAACTACCCAACTATGATGCTAGGGAAATTGTGAACAATGTCAG ACGAATGCTAGATGGCCTGGATCCTCATCCCATGCTTCCAAACTACAAAAACTTTAAAGGCACGATTCAAGAACTTGGTCAAAACCAGTA TGCAGTCAGTGGTGAAATATTTGTAGTGGACAGAAACACAGTAGAAATTACAGAGCTTCCAGTTAGAACTTGGACACAGGTATATAAAGA ACAGGTTTTAGAACCTATGCTAAATGGAACAGATAAAACACCAGCATTAATTTCTGATTATAAAGAATATCATACTGACACAACTGTGAA ATTTGTGGTGAAAATGACTGAAGAGAAACTAGCACAAGCAGAAGCTGCTGGACTGCATAAAGTTTTTAAACTTCAAACTACTCTTACTTG TAATTCCATGGTACTTTTTGATCATATGGGATGTCTGAAGAAATATGAAACTGTGCAAGACATTCTGAAAGAATTCTTTGATTTACGATT AAGTTATTACGGTTTACGTAAGGAGTGGCTTGTGGGAATGTTGGGAGCAGAATCTACAAAGCTTAACAATCAAGCCCGTTTCATTTTAGA GAAGATACAAGGGAAAATTACTATAGAGAATAGGTCAAAGAAAGATTTGATTCAAATGTTAGTCCAGAGAGGTTATGAATCTGACCCAGT GAAAGCCTGGAAAGAAGCACAAGAAAAGGCAGCAGAAGAGGATGAAACACAAAACCAGCATGATGATAGTTCCTCCGATTCAGGAACTCC TTCAGGCCCAGATTTTAATTATATTTTAAATATGTCTCTGTGGTCTCTTACTAAAGAAAAAGTTGAAGAACTGATTAAACAGAGAGATGC AAAAGGGCGAGAGGTCAATGATCTTAAAAGAAAATCTCCTTCAGATCTTTGGAAAGAGGATTTAGCGGCATTTGTTGAAGAACTGGATAA AGTGGAATCTCAAGAACGAGAAGATGTTCTGGCTGGAATGTCTGGAAAAGCAATTAAAGGTAAAGTTGGCAAACCTAAGGTGAAGAAACT CCAGTTGGAAGAGACAATGCCCTCACCTTATGGCAGAAGAATAATTCCTGAAATTACAGCTATGAAGGCAGATGCCAGCAAAAAGTTGCT GAAGAAGAAGAAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATT ACTTCGAGACACTATTAATGGGCTTAATAAGCAGAGGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGT GGAGCTTGTTGAATTTATATCTCCCAAAACCCCTAAACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCG AGGTGAAATGGGTCTACAGAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATAT TGTGAAAGATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAG AAAAGTTGAAACAGACTGGCACATGGTATATTTGGCCCGAAAGGAAGGATCATCTTTTGCTTATATTTCCTGGAAGTTTGAGTGTGGGTC AGTTGGCCTAAAAGTAGATAGCATTTCTATTAGAACAAGTAGTCAAACTTTTCAGACTGGAACAGTAGAATGGAAATTGCGATCTGATAC AGCACAAGTAGAACTGACAGGCGATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAG CAGAGGAGATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTAT AAAATTCAGTGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCATG CTTAGTTGGCAGTTACCACCCTGTGCTAGCATATTTCTTTTGCTAGCTATCCATCATGTAACCCTCATGAAAATTATCTTTATACGTGGA CTATAATAAAATATTGAATTAAAACCTTTCTTCCATATGTGACTATAATTTGGAGTAAAGTCTTGTTGACTCAATATGGGATTTTAATCT AAAACTGTAAGTATGGTTTTAAAAGTTAAATAATGATATTCATGATTAAATGCTATTCATGATTATGATAAAATCTTGGGCTTATGATAG TAATTTGACATTTTCTGATCAGCCATTCATTTCTTCAGAAGTGGTTAAATTAGAGTCTCCTAATATTTTTAATTAATGTGAAAGTACAGT >93094_93094_9_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000435706_NGLY1_chr3_25775473_ENST00000428257_length(amino acids)=1533AA_BP=1262 MEALAMAKSGGCGAGAGVGGGNGALTWVNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGS CRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSS VKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK IKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQ FGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFV VKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKG REVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK KKVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVAWRVARGE MGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMVYLARKEGSSFAYISWKFECGSVG LKVDSISIRTSSQTFQTGTVEWKLRSDTAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEENCLEIIIKF -------------------------------------------------------------- >93094_93094_10_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000435706_NGLY1_chr3_25775473_ENST00000467224_length(transcript)=4695nt_BP=3973nt TTTGAGGGCAGCCGGCGGCGCGGCCTCCTCAGCGGGCTCGGCTGGACGTCCGCTCCGGATCTTCGCGATGGGGCGCGGGGGTCGGCGCGG CTAGGAGTGCGGCGAGTGGAGCGGTGGGTGCGGAGCGGCGGGGCCCAGCGGCCCGCAGGGAGGCGGGAGCGGCGGCTGCGGCCTCAGGGC CTGTGAGCTGGAGGCACTCGCCATGGCCAAGTCGGGTGGCTGCGGCGCGGGAGCCGGCGTGGGCGGCGGCAACGGGGCACTGACCTGGGT GAACAATGCTGCAAAAAAAGAAGAGTCAGAAACTGCCAACAAAAATGATTCTTCAAAGAAGTTGTCTGTTGAGAGAGTGTATCAGAAGAA GACACAACTTGAACACATTCTTCTTCGTCCTGATACATATATTGGGTCAGTGGAGCCATTGACGCAGTTCATGTGGGTGTATGATGAAGA TGTAGGAATGAATTGCAGGGAGGTTACCTTTGTGCCAGGTTTATACAAGATCTTTGATGAAATTTTGGTTAATGCTGCTGACAATAAACA GAGGGATAAGAACATGACTTGTATTAAAGTTTCTATTGATCCTGAATCTAACATTATAAGCATTTGGAATAATGGGAAAGGCATTCCAGT AGTAGAACACAAGGTAGAGAAAGTTTATGTTCCTGCTTTAATTTTTGGACAGCTTTTAACATCCAGTAACTATGATGATGATGAGAAAAA AGTTACAGGTGGTCGTAATGGTTATGGTGCAAAACTTTGTAATATTTTCAGTACAAAGTTTACAGTAGAAACAGCTTGCAAAGAATACAA ACACAGTTTTAAGCAGACATGGATGAATAATATGATGAAGACTTCTGAAGCCAAAATTAAACATTTTGATGGTGAAGATTACACATGCAT AACATTCCAACCAGATCTGTCCAAATTTAAGATGGAAAAACTTGACAAGGATATTGTGGCCCTCATGACTAGAAGGGCATATGATTTGGC TGGTTCGTGTAGAGGGGTCAAGGTCATGTTTAATGGAAAGAAATTGCCTGTAAATGGATTTCGCAGTTATGTAGATCTTTATGTGAAAGA CAAATTGGATGAAACTGGGGTGGCCCTGAAAGTTATTCATGAGCTTGCAAATGAAAGATGGGATGTTTGTCTCACATTGAGTGAAAAAGG ATTCCAGCAAATCAGCTTTGTAAATAGTATTGCAACTACAAAAGGTGGACGGCACGTGGATTATGTGGTAGATCAAGTTGTTGGTAAACT GATTGAAGTAGTTAAGAAAAAGAACAAAGCTGGTGTATCAGTGAAACCATTTCAAGTAAAAAACCATATATGGGTTTTTATTAATTGCCT TATTGAAAATCCAACTTTTGATTCTCAGACTAAGGAAAACATGACTCTGCAGCCCAAAAGTTTTGGGTCTAAATGCCAGCTGTCAGAAAA ATTTTTTAAAGCAGCCTCTAATTGTGGCATTGTAGAAAGTATCCTGAACTGGGTGAAATTTAAGGCTCAGACTCAGCTGAATAAGAAGTG TTCATCAGTAAAATACAGTAAAATCAAAGGTATTCCCAAACTGGATGATGCTAATGATGCTGGTGGTAAACATTCCCTGGAGTGTACACT GATATTAACAGAGGGAGACTCTGCCAAATCACTGGCTGTGTCTGGATTAGGTGTGATTGGACGAGACAGATACGGAGTTTTTCCACTCAG GGGCAAAATTCTTAATGTACGGGAAGCTTCTCATAAACAGATCATGGAAAATGCTGAAATAAATAATATTATTAAAATAGTTGGTCTACA ATATAAGAAAAGTTACGATGATGCAGAATCTCTGAAAACCTTACGCTATGGAAAGATTATGATTATGACCGATCAGGATCAAGATGGTTC TCACATAAAAGGCCTGCTTATTAATTTCATCCATCACAATTGGCCATCACTTTTGAAGCATGGTTTTCTTGAAGAGTTCATTACTCCTAT TGTAAAGGCAAGCAAAAATAAGCAGGAACTTTCCTTCTACAGTATTCCTGAATTTGACGAATGGAAAAAACATATAGAAAACCAGAAAGC CTGGAAAATAAAGTACTATAAAGGATTGGGTACTAGTACAGCTAAAGAAGCAAAGGAATATTTTGCTGATATGGAAAGGCATCGCATCTT GTTTAGATATGCTGGTCCTGAAGATGATGCTGCCATTACCTTGGCATTTAGTAAGAAGAAGATTGATGACAGAAAAGAATGGTTAACAAA TTTTATGGAAGACCGGAGACAGCGTAGGCTACATGGCTTACCAGAGCAATTTTTATATGGTACTGCAACAAAGCATTTGACTTATAATGA TTTCATCAACAAGGAATTGATTCTCTTCTCAAACTCAGACAATGAAAGATCTATACCATCTCTTGTTGATGGCTTTAAACCTGGCCAGCG GAAAGTTTTATTTACCTGTTTCAAGAGGAATGATAAACGTGAAGTAAAAGTTGCCCAGTTGGCTGGCTCTGTTGCTGAGATGTCGGCTTA TCATCATGGAGAACAAGCATTGATGATGACTATTGTGAATTTGGCTCAGAACTTTGTGGGAAGTAACAACATTAACTTGCTTCAGCCTAT TGGTCAGTTTGGAACTCGGCTTCATGGTGGCAAAGATGCTGCAAGCCCTCGTTATATTTTCACAATGTTAAGCACTTTAGCAAGGCTACT TTTTCCTGCTGTGGATGACAACCTCCTTAAGTTCCTTTATGATGATAATCAACGTGTAGAGCCTGAGTGGTATATTCCTATAATTCCCAT GGTTTTAATAAATGGTGCTGAGGGCATTGGTACTGGATGGGCTTGTAAACTACCCAACTATGATGCTAGGGAAATTGTGAACAATGTCAG ACGAATGCTAGATGGCCTGGATCCTCATCCCATGCTTCCAAACTACAAAAACTTTAAAGGCACGATTCAAGAACTTGGTCAAAACCAGTA TGCAGTCAGTGGTGAAATATTTGTAGTGGACAGAAACACAGTAGAAATTACAGAGCTTCCAGTTAGAACTTGGACACAGGTATATAAAGA ACAGGTTTTAGAACCTATGCTAAATGGAACAGATAAAACACCAGCATTAATTTCTGATTATAAAGAATATCATACTGACACAACTGTGAA ATTTGTGGTGAAAATGACTGAAGAGAAACTAGCACAAGCAGAAGCTGCTGGACTGCATAAAGTTTTTAAACTTCAAACTACTCTTACTTG TAATTCCATGGTACTTTTTGATCATATGGGATGTCTGAAGAAATATGAAACTGTGCAAGACATTCTGAAAGAATTCTTTGATTTACGATT AAGTTATTACGGTTTACGTAAGGAGTGGCTTGTGGGAATGTTGGGAGCAGAATCTACAAAGCTTAACAATCAAGCCCGTTTCATTTTAGA GAAGATACAAGGGAAAATTACTATAGAGAATAGGTCAAAGAAAGATTTGATTCAAATGTTAGTCCAGAGAGGTTATGAATCTGACCCAGT GAAAGCCTGGAAAGAAGCACAAGAAAAGGCAGCAGAAGAGGATGAAACACAAAACCAGCATGATGATAGTTCCTCCGATTCAGGAACTCC TTCAGGCCCAGATTTTAATTATATTTTAAATATGTCTCTGTGGTCTCTTACTAAAGAAAAAGTTGAAGAACTGATTAAACAGAGAGATGC AAAAGGGCGAGAGGTCAATGATCTTAAAAGAAAATCTCCTTCAGATCTTTGGAAAGAGGATTTAGCGGCATTTGTTGAAGAACTGGATAA AGTGGAATCTCAAGAACGAGAAGATGTTCTGGCTGGAATGTCTGGAAAAGCAATTAAAGGTAAAGTTGGCAAACCTAAGGTGAAGAAACT CCAGTTGGAAGAGACAATGCCCTCACCTTATGGCAGAAGAATAATTCCTGAAATTACAGCTATGAAGGCAGATGCCAGCAAAAAGTTGCT GAAGAAGAAGAAGAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCA TTACTTCGAGACACTATTAATGGGCTTAATAAGCAGAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTC CACCTTTGTTACAATATTGTGAAAGATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAA ATGGAATCTATATTCAGAAAAGTTGAAACAGACTGGCACATGGTATATTTGGCCCGAAAGGAAGGATCATCTTTTGCTTATATTTCCTGG AAGTTTGAGTGTGGATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGGAGA TGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTATAAAATTCAG TGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCATGCTTAGTTGG CAGTTACCACCCTGTGCTAGCATATTTCTTTTGCTAGCTATCCATCATGTAACCCTCATGAAAATTATCTTTATACGTGGACTATAATAA >93094_93094_10_TOP2B-NGLY1_TOP2B_chr3_25654006_ENST00000435706_NGLY1_chr3_25775473_ENST00000467224_length(amino acids)=1263AA_BP= MEALAMAKSGGCGAGAGVGGGNGALTWVNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG MNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGS CRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSS VKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK IKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQ FGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFV VKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKG REVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TOP2B-NGLY1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000264331 | - | 28 | 36 | 1011_1020 | 1262.0 | 1627.0 | DNA |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000435706 | - | 28 | 36 | 1011_1020 | 1257.0 | 1622.0 | DNA |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000264331 | - | 28 | 36 | 363_365 | 1262.0 | 1627.0 | DNA |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000435706 | - | 28 | 36 | 363_365 | 1257.0 | 1622.0 | DNA |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000264331 | - | 28 | 36 | 1506_1512 | 1262.0 | 1627.0 | PLSCR1 |
| Hgene | TOP2B | chr3:25654006 | chr3:25775473 | ENST00000435706 | - | 28 | 36 | 1506_1512 | 1257.0 | 1622.0 | PLSCR1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TOP2B-NGLY1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TOP2B-NGLY1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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