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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TOP3A-MYO18A (FusionGDB2 ID:93105)

Fusion Gene Summary for TOP3A-MYO18A

check button Fusion gene summary
Fusion gene informationFusion gene name: TOP3A-MYO18A
Fusion gene ID: 93105
HgeneTgene
Gene symbol

TOP3A

MYO18A

Gene ID

7156

399687

Gene nameDNA topoisomerase III alphamyosin XVIIIA
SynonymsMGRISCE2|PEOB5|TOP3|ZGRF7MAJN|MYSPDZ|SP-R210|SPR210
Cytomap

17p11.2

17q11.2

Type of geneprotein-codingprotein-coding
DescriptionDNA topoisomerase 3-alphatopo III-alphatopoisomerase (DNA) III alphazinc finger, GRF-type containing 7unconventional myosin-XVIIIaSP-A receptor subunit SP-R210 alphaSmolecule associated with JAK3 N-terminusmyosin 18Amyosin containing PDZ domainmyosin containing a PDZ domainsurfactant protein receptor SP-R210
Modification date2020031320200313
UniProtAcc.

Q92614

Ensembl transtripts involved in fusion geneENST00000321105, ENST00000542570, 
ENST00000540524, ENST00000582230, 
ENST00000527372, ENST00000529578, 
ENST00000531253, ENST00000533112, 
ENST00000354329, 
Fusion gene scores* DoF score9 X 10 X 6=54020 X 17 X 12=4080
# samples 1234
** MAII scorelog2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(34/4080*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TOP3A [Title/Abstract] AND MYO18A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTOP3A(18202873)-MYO18A(27430682), # samples:3
Anticipated loss of major functional domain due to fusion event.TOP3A-MYO18A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTOP3A

GO:0006265

DNA topological change

20445207


check buttonFusion gene breakpoints across TOP3A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYO18A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-38-4630-01ATOP3Achr17

18202873

-MYO18Achr17

27430682

-
ChimerDB4LUADTCGA-38-4630TOP3Achr17

18202872

-MYO18Achr17

27430682

-


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Fusion Gene ORF analysis for TOP3A-MYO18A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000321105ENST00000527372TOP3Achr17

18202873

-MYO18Achr17

27430682

-
5CDS-intronENST00000321105ENST00000527372TOP3Achr17

18202872

-MYO18Achr17

27430682

-
5CDS-intronENST00000321105ENST00000529578TOP3Achr17

18202873

-MYO18Achr17

27430682

-
5CDS-intronENST00000321105ENST00000529578TOP3Achr17

18202872

-MYO18Achr17

27430682

-
5CDS-intronENST00000321105ENST00000531253TOP3Achr17

18202873

-MYO18Achr17

27430682

-
5CDS-intronENST00000321105ENST00000531253TOP3Achr17

18202872

-MYO18Achr17

27430682

-
5CDS-intronENST00000321105ENST00000533112TOP3Achr17

18202873

-MYO18Achr17

27430682

-
5CDS-intronENST00000321105ENST00000533112TOP3Achr17

18202872

-MYO18Achr17

27430682

-
5CDS-intronENST00000542570ENST00000527372TOP3Achr17

18202873

-MYO18Achr17

27430682

-
5CDS-intronENST00000542570ENST00000527372TOP3Achr17

18202872

-MYO18Achr17

27430682

-
5CDS-intronENST00000542570ENST00000529578TOP3Achr17

18202873

-MYO18Achr17

27430682

-
5CDS-intronENST00000542570ENST00000529578TOP3Achr17

18202872

-MYO18Achr17

27430682

-
5CDS-intronENST00000542570ENST00000531253TOP3Achr17

18202873

-MYO18Achr17

27430682

-
5CDS-intronENST00000542570ENST00000531253TOP3Achr17

18202872

-MYO18Achr17

27430682

-
5CDS-intronENST00000542570ENST00000533112TOP3Achr17

18202873

-MYO18Achr17

27430682

-
5CDS-intronENST00000542570ENST00000533112TOP3Achr17

18202872

-MYO18Achr17

27430682

-
5UTR-3CDSENST00000540524ENST00000354329TOP3Achr17

18202873

-MYO18Achr17

27430682

-
5UTR-3CDSENST00000540524ENST00000354329TOP3Achr17

18202872

-MYO18Achr17

27430682

-
5UTR-intronENST00000540524ENST00000527372TOP3Achr17

18202873

-MYO18Achr17

27430682

-
5UTR-intronENST00000540524ENST00000527372TOP3Achr17

18202872

-MYO18Achr17

27430682

-
5UTR-intronENST00000540524ENST00000529578TOP3Achr17

18202873

-MYO18Achr17

27430682

-
5UTR-intronENST00000540524ENST00000529578TOP3Achr17

18202872

-MYO18Achr17

27430682

-
5UTR-intronENST00000540524ENST00000531253TOP3Achr17

18202873

-MYO18Achr17

27430682

-
5UTR-intronENST00000540524ENST00000531253TOP3Achr17

18202872

-MYO18Achr17

27430682

-
5UTR-intronENST00000540524ENST00000533112TOP3Achr17

18202873

-MYO18Achr17

27430682

-
5UTR-intronENST00000540524ENST00000533112TOP3Achr17

18202872

-MYO18Achr17

27430682

-
Frame-shiftENST00000542570ENST00000354329TOP3Achr17

18202873

-MYO18Achr17

27430682

-
Frame-shiftENST00000542570ENST00000354329TOP3Achr17

18202872

-MYO18Achr17

27430682

-
In-frameENST00000321105ENST00000354329TOP3Achr17

18202873

-MYO18Achr17

27430682

-
In-frameENST00000321105ENST00000354329TOP3Achr17

18202872

-MYO18Achr17

27430682

-
intron-3CDSENST00000582230ENST00000354329TOP3Achr17

18202873

-MYO18Achr17

27430682

-
intron-3CDSENST00000582230ENST00000354329TOP3Achr17

18202872

-MYO18Achr17

27430682

-
intron-intronENST00000582230ENST00000527372TOP3Achr17

18202873

-MYO18Achr17

27430682

-
intron-intronENST00000582230ENST00000527372TOP3Achr17

18202872

-MYO18Achr17

27430682

-
intron-intronENST00000582230ENST00000529578TOP3Achr17

18202873

-MYO18Achr17

27430682

-
intron-intronENST00000582230ENST00000529578TOP3Achr17

18202872

-MYO18Achr17

27430682

-
intron-intronENST00000582230ENST00000531253TOP3Achr17

18202873

-MYO18Achr17

27430682

-
intron-intronENST00000582230ENST00000531253TOP3Achr17

18202872

-MYO18Achr17

27430682

-
intron-intronENST00000582230ENST00000533112TOP3Achr17

18202873

-MYO18Achr17

27430682

-
intron-intronENST00000582230ENST00000533112TOP3Achr17

18202872

-MYO18Achr17

27430682

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000321105TOP3Achr1718202873-ENST00000354329MYO18Achr1727430682-518912056839281286
ENST00000321105TOP3Achr1718202872-ENST00000354329MYO18Achr1727430682-518912056839281286

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000321105ENST00000354329TOP3Achr1718202873-MYO18Achr1727430682-0.0079404610.99205947
ENST00000321105ENST00000354329TOP3Achr1718202872-MYO18Achr1727430682-0.0079404610.99205947

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Fusion Genomic Features for TOP3A-MYO18A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TOP3A-MYO18A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:18202873/chr17:27430682)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MYO18A

Q92614

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTOP3Achr17:18202872chr17:27430682ENST00000321105-91935_1793301002.0DomainToprim
HgeneTOP3Achr17:18202873chr17:27430682ENST00000321105-91935_1793301002.0DomainToprim
TgeneMYO18Achr17:18202872chr17:27430682ENST0000052737219421246_197111472055.0Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr17:18202872chr17:27430682ENST0000053125319411246_197111472040.0Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr17:18202872chr17:27430682ENST0000053311219401246_197111472003.0Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr17:18202873chr17:27430682ENST0000052737219421246_197111472055.0Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr17:18202873chr17:27430682ENST0000053125319411246_197111472040.0Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr17:18202873chr17:27430682ENST0000053311219401246_197111472003.0Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr17:18202872chr17:27430682ENST0000052737219421188_121711472055.0DomainIQ
TgeneMYO18Achr17:18202872chr17:27430682ENST0000053125319411188_121711472040.0DomainIQ
TgeneMYO18Achr17:18202872chr17:27430682ENST0000053311219401188_121711472003.0DomainIQ
TgeneMYO18Achr17:18202873chr17:27430682ENST0000052737219421188_121711472055.0DomainIQ
TgeneMYO18Achr17:18202873chr17:27430682ENST0000053125319411188_121711472040.0DomainIQ
TgeneMYO18Achr17:18202873chr17:27430682ENST0000053311219401188_121711472003.0DomainIQ

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTOP3Achr17:18202872chr17:27430682ENST00000321105-919658_6853301002.0Zinc fingerC4-type
HgeneTOP3Achr17:18202872chr17:27430682ENST00000321105-919811_8513301002.0Zinc fingerNote=GRF-type 1
HgeneTOP3Achr17:18202872chr17:27430682ENST00000321105-919896_9393301002.0Zinc fingerNote=GRF-type 2
HgeneTOP3Achr17:18202873chr17:27430682ENST00000321105-919658_6853301002.0Zinc fingerC4-type
HgeneTOP3Achr17:18202873chr17:27430682ENST00000321105-919811_8513301002.0Zinc fingerNote=GRF-type 1
HgeneTOP3Achr17:18202873chr17:27430682ENST00000321105-919896_9393301002.0Zinc fingerNote=GRF-type 2
TgeneMYO18Achr17:18202872chr17:27430682ENST0000052737219426_2511472055.0Compositional biasNote=Lys-rich
TgeneMYO18Achr17:18202872chr17:27430682ENST0000053125319416_2511472040.0Compositional biasNote=Lys-rich
TgeneMYO18Achr17:18202872chr17:27430682ENST0000053311219406_2511472003.0Compositional biasNote=Lys-rich
TgeneMYO18Achr17:18202873chr17:27430682ENST0000052737219426_2511472055.0Compositional biasNote=Lys-rich
TgeneMYO18Achr17:18202873chr17:27430682ENST0000053125319416_2511472040.0Compositional biasNote=Lys-rich
TgeneMYO18Achr17:18202873chr17:27430682ENST0000053311219406_2511472003.0Compositional biasNote=Lys-rich
TgeneMYO18Achr17:18202872chr17:27430682ENST000005273721942220_31111472055.0DomainPDZ
TgeneMYO18Achr17:18202872chr17:27430682ENST000005273721942349_40111472055.0DomainMyosin N-terminal SH3-like
TgeneMYO18Achr17:18202872chr17:27430682ENST000005273721942405_118511472055.0DomainMyosin motor
TgeneMYO18Achr17:18202872chr17:27430682ENST000005312531941220_31111472040.0DomainPDZ
TgeneMYO18Achr17:18202872chr17:27430682ENST000005312531941349_40111472040.0DomainMyosin N-terminal SH3-like
TgeneMYO18Achr17:18202872chr17:27430682ENST000005312531941405_118511472040.0DomainMyosin motor
TgeneMYO18Achr17:18202872chr17:27430682ENST000005331121940220_31111472003.0DomainPDZ
TgeneMYO18Achr17:18202872chr17:27430682ENST000005331121940349_40111472003.0DomainMyosin N-terminal SH3-like
TgeneMYO18Achr17:18202872chr17:27430682ENST000005331121940405_118511472003.0DomainMyosin motor
TgeneMYO18Achr17:18202873chr17:27430682ENST000005273721942220_31111472055.0DomainPDZ
TgeneMYO18Achr17:18202873chr17:27430682ENST000005273721942349_40111472055.0DomainMyosin N-terminal SH3-like
TgeneMYO18Achr17:18202873chr17:27430682ENST000005273721942405_118511472055.0DomainMyosin motor
TgeneMYO18Achr17:18202873chr17:27430682ENST000005312531941220_31111472040.0DomainPDZ
TgeneMYO18Achr17:18202873chr17:27430682ENST000005312531941349_40111472040.0DomainMyosin N-terminal SH3-like
TgeneMYO18Achr17:18202873chr17:27430682ENST000005312531941405_118511472040.0DomainMyosin motor
TgeneMYO18Achr17:18202873chr17:27430682ENST000005331121940220_31111472003.0DomainPDZ
TgeneMYO18Achr17:18202873chr17:27430682ENST000005331121940349_40111472003.0DomainMyosin N-terminal SH3-like
TgeneMYO18Achr17:18202873chr17:27430682ENST000005331121940405_118511472003.0DomainMyosin motor
TgeneMYO18Achr17:18202872chr17:27430682ENST000005273721942498_50511472055.0Nucleotide bindingATP
TgeneMYO18Achr17:18202872chr17:27430682ENST000005312531941498_50511472040.0Nucleotide bindingATP
TgeneMYO18Achr17:18202872chr17:27430682ENST000005331121940498_50511472003.0Nucleotide bindingATP
TgeneMYO18Achr17:18202873chr17:27430682ENST000005273721942498_50511472055.0Nucleotide bindingATP
TgeneMYO18Achr17:18202873chr17:27430682ENST000005312531941498_50511472040.0Nucleotide bindingATP
TgeneMYO18Achr17:18202873chr17:27430682ENST000005331121940498_50511472003.0Nucleotide bindingATP


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Fusion Gene Sequence for TOP3A-MYO18A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93105_93105_1_TOP3A-MYO18A_TOP3A_chr17_18202872_ENST00000321105_MYO18A_chr17_27430682_ENST00000354329_length(transcript)=5189nt_BP=1205nt
GAAGTTCCACGCCAAGATACTGGATTCGGTGCTGAGGCGGCGGCTGCGGCACGGGAAAGGCTCAGTGACTGAAGCTCCAAAGGCCAGCAG
GCTGGTGGGGACGTGACCGAAGCGAGGCTCTGGTTCCCTTTCGGTGGGCGCCATTTGAGCCTCATCTCTGGCTTCCCCAGGATGCGCCGG
CAGCCGGGGAGCGGCTCCGGGCGCGAGGTCTGAGGATGATCTTTCCTGTCGCCCGCTACGCGCTCCGGTGGCTGCGACGGCCCGAAGACC
GTGCCTTTTCCCGCGCCGCCATGGAGATGGCCCTCCGAGGCGTGCGGAAAGTCCTCTGTGTGGCCGAAAAAAACGACGCGGCCAAGGGGA
TCGCCGACCTGCTGTCAAACGGTCGCATGAGGCGGAGAGAAGGACTTTCAAAATTCAACAAGATCTATGAATTTGATTATCATCTGTATG
GCCAGAATGTTACCATGGTAATGACTTCAGTTTCTGGACATTTACTGGCTCATGATTTCCAGATGCAGTTTCGAAAATGGCAGAGCTGCA
ACCCTCTTGTCCTCTTTGAAGCAGAAATTGAAAAGTACTGCCCAGAGAATTTTGTAGACATCAAGAAAACTTTGGAACGAGAGACTCGCC
AGTGCCAGGCTCTGGTGATCTGGACTGACTGTGATAGAGAAGGCGAAAACATCGGGTTTGAGATTATCCACGTGTGTAAGGCTGTAAAGC
CCAATCTGCAGGTGTTGCGAGCCCGATTCTCTGAGATCACACCCCATGCCGTCAGGACAGCTTGTGAAAACCTGACCGAGCCTGATCAGA
GGGTGAGCGATGCTGTGGATGTGAGGCAGGAGCTGGACCTGAGGATTGGAGCTGCCTTTACTAGGTTCCAGACCCTGCGGCTTCAGAGGA
TTTTTCCTGAGGTGCTGGCAGAGCAGCTCATCAGTTACGGCAGCTGCCAGTTCCCCACACTGGGCTTTGTGGTGGAGCGGTTCAAAGCCA
TTCAGGCTTTTGTACCAGAAATCTTCCACAGAATTAAAGTAACTCATGACCACAAAGATGGTATCGTAGAATTCAACTGGAAAAGGCATC
GACTCTTTAACCACACGGCTTGCCTAGTTCTCTATCAGTTGTGTGTGGAGGATCCCATGGCAACTGTGGTAGAGGTCAGATCTAAGCCCA
AGAGCAAGTGGCGGCCTCAAGCCTTGGACACTGTGGCAGTGGAGGAGCTGCTGGAGTGCTTGGATCTGGAGAAGAGCAGCTGCTGCATGG
GCCTGAGCCGGGTGTTCTTCCGGGCGGGCACCTTGGCACGGCTGGAGGAGCAGCGGGATGAACAAACCAGCAGGAACCTAACCCTGTTCC
AAGCAGCCTGCAGGGGCTACCTGGCCCGCCAGCACTTCAAGAAGAGAAAGATCCAGGACCTGGCCATTCGCTGTGTACAGAAGAACATCA
AGAAGAACAAAGGGGTGAAGGACTGGCCCTGGTGGAAGCTTTTTACCACAGTGAGGCCCCTCATCGAAGTACAGCTGTCAGAGGAGCAGA
TCCGGAACAAAGACGAGGAGATCCAGCAGCTGCGGAGCAAGCTCGAGAAGGCGGAGAAGGAGAGGAACGAGCTGCGGCTCAACAGTGACC
GGCTGGAGAGCCGGATCTCAGAGCTGACATCGGAGCTGACAGATGAGCGTAACACAGGAGAGTCCGCCTCCCAGCTGCTGGACGCGGAGA
CAGCAGAGAGGCTCCGGGCTGAGAAGGAGATGAAGGAACTGCAGACCCAGTACGATGCACTGAAGAAGCAGATGGAGGTTATGGAAATGG
AGGTGATGGAGGCCCGTCTCATCCGGGCAGCGGAGATCAACGGGGAAGTGGATGATGATGATGCAGGTGGCGAGTGGCGGCTGAAGTATG
AGCGGGCTGTGCGGGAGGTGGACTTCACCAAGAAACGGCTCCAGCAGGAGTTTGAGGACAAGCTGGAGGTGGAGCAGCAGAACAAGAGGC
AGCTGGAACGGCGGCTCGGGGACCTGCAGGCAGATAGTGAGGAGAGTCAGCGGGCTCTGCAGCAGCTCAAGAAGAAGTGCCAGCGACTGA
CGGCTGAGCTGCAAGACACCAAGCTGCACCTGGAGGGCCAGCAGGTCCGCAACCACGAACTGGAGAAGAAGCAGAGGAGGTTTGACAGTG
AGCTCTCGCAGGCGCATGAGGAGGCCCAGCGGGAGAAGCTGCAGCGGGAGAAGCTGCAGCGGGAGAAGGACATGCTCCTCGCTGAGGCTT
TCAGCCTGAAGCAGCAACTAGAGGAAAAAGACATGGACATTGCAGGGTTCACCCAGAAGGTTGTGTCTCTAGAGGCAGAGCTCCAGGACA
TTTCTTCCCAAGAGTCCAAGGATGAGGCTTCTCTGGCCAAGGTCAAGAAACAGCTCCGGGACCTGGAGGCCAAAGTCAAGGATCAGGAAG
AAGAGCTGGATGAGCAGGCAGGGACCATCCAGATGCTGGAACAGGCCAAGCTGCGTCTGGAGATGGAGATGGAGCGGATGAGACAGACCC
ATTCTAAGGAGATGGAGAGTCGGGATGAGGAGGTGGAGGAGGCCCGGCAGTCGTGTCAGAAGAAGTTAAAACAGATGGAGGTGCAGCTAG
AGGAAGAGTATGAGGACAAGCAGAAGGTTCTGCGAGAGAAGCGGGAGCTGGAGGGCAAGCTCGCCACCCTCAGCGACCAGGTGAACCGGC
GGGACTTTGAGTCAGAGAAGCGGCTGCGGAAGGACCTGAAGCGCACCAAGGCCCTGCTGGCAGATGCCCAGCTCATGCTGGACCACCTGA
AGAACAGTGCTCCCAGCAAGCGAGAGATTGCCCAGCTCAAGAACCAGCTGGAGGAGTCAGAGTTCACCTGTGCGGCAGCCGTGAAAGCAC
GGAAAGCAATGGAGGTGGAGATCGAAGACCTGCACCTGCAGATTGATGACATCGCCAAAGCCAAGACAGCGCTGGAGGAGCAGCTGAGCC
GCCTTCAGCGTGAGAAGAATGAGATCCAGAACCGGCTGGAGGAAGATCAGGAAGACATGAACGAATTGATGAAGAAGCACAAGGCTGCCG
TGGCTCAGGCTTCCCGGGACCTGGCTCAGATAAATGATCTCCAAGCTCAGCTAGAAGAAGCCAACAAAGAGAAGCAGGAGCTGCAGGAGA
AGCTACAAGCCCTCCAGAGCCAGGTGGAGTTCCTGGAGCAGTCCATGGTGGACAAGTCCCTGGTGAGCAGGCAGGAAGCTAAGATACGGG
AGCTGGAGACACGCCTGGAGTTTGAAAGGACGCAAGTGAAACGGCTGGAGAGCCTGGCTAGCCGTCTCAAGGAAAACATGGAGAAGCTGA
CTGAGGAGCGGGATCAGCGCATTGCAGCCGAGAACCGGGAGAAGGAACAGAACAAGCGGCTACAGAGGCAGCTCCGGGACACCAAGGAGG
AGATGGGCGAGCTTGCCAGGAAGGAGGCCGAGGCGAGCCGCAAGAAGCACGAACTGGAGATGGATCTAGAAAGCCTGGAGGCTGCTAACC
AGAGCCTGCAGGCTGACCTAAAGTTGGCATTCAAGCGCATCGGGGACCTGCAGGCTGCCATTGAGGATGAGATGGAGAGTGATGAGAATG
AGGACCTCATCAACAGTTTGCAGGACATGGTGACAAAGTATCAGAAAAGAAAGAATAAACTTGAGGGAGACTCTGATGTGGACTCGGAGC
TGGAGGACCGTGTTGACGGGGTCAAGTCCTGGTTGTCAAAAAACAAGGGACCTTCCAAGGCAGCTTCTGATGATGGCAGCTTAAAGAGTT
CCAGCCCCACCAGCTACTGGAAGTCCCTTGCCCCTGATCGGTCAGATGATGAGCACGACCCTCTCGACAACACCTCCAGACCGCGATACT
CCCACAGTTATCTGAGTGACAGCGACACAGAGGCCAAGCTGACGGAGACTAACGCATAGCCCAGGGGAGTGGTTGGCAGCCCTCTCACCC
CAGGGCCTGTGGCTGCCTGGGCACCTCTCCCAGGAAGTGGTGGGGCACCGGTCTCCCCCACCCGACTGCTGATCTGCATGGGAAACACCC
TGACCTTCTTCTGTCAGGGGCACTTTCCAGGCTATGGGTGTCTGATGTCTCCACGTGGAAGAGGTGGGGGAAAGAGGAGTTTCTGAAGAG
AACTTTTTGCTCCTCTGTCTCAAAATGCCAGACTCTTGGCTTCTACCCTGTGTCACCGTGGGCAGTGGCAGGTGGCCTGGCACTGCATGG
AGCCAGCACGTTGACCTCCCTCTCAGCTCCCTGCTCAGGGACGGTGGACAGGTTGCCTACTGGGACACTCTAGGTTGCTGGGTCCATGGG
GAGGATTGGGGGAGGAGAAGCAGTGCCTTCCCTCTCGTGTGGGGTGGGGGCTCTCTCTTCTTGGTGCCTGCTGTCTTTCTACTTTTTAAT
TTAAATACCCAACCTCTCCATCACAGCTGCATCCCTGAGAGTGGGAGGGGGCTGTAGTGGTAGCTGGGGCTCCCAAGAACGACTCGGGAA
TGTCATCTCCATCTTCACCCTTCAGAGAGCAGTCCTTTCTCTGTGCAGCTGGAGACGCTGGTGAGGAGAGCCGGGTCCAGGTTCTTAAGA
ATGAGGTGCGGAGGGGCTCTCCGGTGCTGCTGGGCTGGGTTGAGCAAGCCTACGCAGACAAGTGTGTGTGTGGACCATCCGCACCTCCAG
CCCCCACCCCACCCTCTTTGTCTCAGCGTGTTATGTGCAATGACCTATTTAAGGTAAACCCATTCCAACTACAGCAGTTCAGGGCTGATC
CAAGCACTGCCTCCCTCCTGCTCTGTCCAGGTGGTCTGGACCATAAACTCAACTTGAGAGGGAAGGCTTGGGGTTGAGGACTTGTGATCA
GAAAAACTGAAGATGGAAGTTTTGGCCGGTGCTCATTAGACATGAGTCCTCACTCTGTGTCCTGAGCCCGTGTCATTCTTCCAACCTCCC
TGCCCCCACACACTTATCCCAGACACAACACCATGTGGTCTGGAGGTCCCAGCCCCCACCCTAAAAAGGTTATCCCTGAGAACTCCACCA
GACTTGGGAGCCCAAGTGCAGTGCCTGGTGCTGCTCCCATCTGCCGCCCCCCTTCTCTCCTGCAATTGGTTTGTACTCACTGGGCTGTGC

>93105_93105_1_TOP3A-MYO18A_TOP3A_chr17_18202872_ENST00000321105_MYO18A_chr17_27430682_ENST00000354329_length(amino acids)=1286AA_BP=379
MKLQRPAGWWGRDRSEALVPFRWAPFEPHLWLPQDAPAAGERLRARGLRMIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAE
KNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKK
TLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRF
QTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATV
VEVRSKPKSKWRPQALDTVAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAI
RCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESA
SQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLE
VEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREK
DMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEME
MERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADA
QLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNEL
MKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRL
KENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIED
EMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPLD

--------------------------------------------------------------
>93105_93105_2_TOP3A-MYO18A_TOP3A_chr17_18202873_ENST00000321105_MYO18A_chr17_27430682_ENST00000354329_length(transcript)=5189nt_BP=1205nt
GAAGTTCCACGCCAAGATACTGGATTCGGTGCTGAGGCGGCGGCTGCGGCACGGGAAAGGCTCAGTGACTGAAGCTCCAAAGGCCAGCAG
GCTGGTGGGGACGTGACCGAAGCGAGGCTCTGGTTCCCTTTCGGTGGGCGCCATTTGAGCCTCATCTCTGGCTTCCCCAGGATGCGCCGG
CAGCCGGGGAGCGGCTCCGGGCGCGAGGTCTGAGGATGATCTTTCCTGTCGCCCGCTACGCGCTCCGGTGGCTGCGACGGCCCGAAGACC
GTGCCTTTTCCCGCGCCGCCATGGAGATGGCCCTCCGAGGCGTGCGGAAAGTCCTCTGTGTGGCCGAAAAAAACGACGCGGCCAAGGGGA
TCGCCGACCTGCTGTCAAACGGTCGCATGAGGCGGAGAGAAGGACTTTCAAAATTCAACAAGATCTATGAATTTGATTATCATCTGTATG
GCCAGAATGTTACCATGGTAATGACTTCAGTTTCTGGACATTTACTGGCTCATGATTTCCAGATGCAGTTTCGAAAATGGCAGAGCTGCA
ACCCTCTTGTCCTCTTTGAAGCAGAAATTGAAAAGTACTGCCCAGAGAATTTTGTAGACATCAAGAAAACTTTGGAACGAGAGACTCGCC
AGTGCCAGGCTCTGGTGATCTGGACTGACTGTGATAGAGAAGGCGAAAACATCGGGTTTGAGATTATCCACGTGTGTAAGGCTGTAAAGC
CCAATCTGCAGGTGTTGCGAGCCCGATTCTCTGAGATCACACCCCATGCCGTCAGGACAGCTTGTGAAAACCTGACCGAGCCTGATCAGA
GGGTGAGCGATGCTGTGGATGTGAGGCAGGAGCTGGACCTGAGGATTGGAGCTGCCTTTACTAGGTTCCAGACCCTGCGGCTTCAGAGGA
TTTTTCCTGAGGTGCTGGCAGAGCAGCTCATCAGTTACGGCAGCTGCCAGTTCCCCACACTGGGCTTTGTGGTGGAGCGGTTCAAAGCCA
TTCAGGCTTTTGTACCAGAAATCTTCCACAGAATTAAAGTAACTCATGACCACAAAGATGGTATCGTAGAATTCAACTGGAAAAGGCATC
GACTCTTTAACCACACGGCTTGCCTAGTTCTCTATCAGTTGTGTGTGGAGGATCCCATGGCAACTGTGGTAGAGGTCAGATCTAAGCCCA
AGAGCAAGTGGCGGCCTCAAGCCTTGGACACTGTGGCAGTGGAGGAGCTGCTGGAGTGCTTGGATCTGGAGAAGAGCAGCTGCTGCATGG
GCCTGAGCCGGGTGTTCTTCCGGGCGGGCACCTTGGCACGGCTGGAGGAGCAGCGGGATGAACAAACCAGCAGGAACCTAACCCTGTTCC
AAGCAGCCTGCAGGGGCTACCTGGCCCGCCAGCACTTCAAGAAGAGAAAGATCCAGGACCTGGCCATTCGCTGTGTACAGAAGAACATCA
AGAAGAACAAAGGGGTGAAGGACTGGCCCTGGTGGAAGCTTTTTACCACAGTGAGGCCCCTCATCGAAGTACAGCTGTCAGAGGAGCAGA
TCCGGAACAAAGACGAGGAGATCCAGCAGCTGCGGAGCAAGCTCGAGAAGGCGGAGAAGGAGAGGAACGAGCTGCGGCTCAACAGTGACC
GGCTGGAGAGCCGGATCTCAGAGCTGACATCGGAGCTGACAGATGAGCGTAACACAGGAGAGTCCGCCTCCCAGCTGCTGGACGCGGAGA
CAGCAGAGAGGCTCCGGGCTGAGAAGGAGATGAAGGAACTGCAGACCCAGTACGATGCACTGAAGAAGCAGATGGAGGTTATGGAAATGG
AGGTGATGGAGGCCCGTCTCATCCGGGCAGCGGAGATCAACGGGGAAGTGGATGATGATGATGCAGGTGGCGAGTGGCGGCTGAAGTATG
AGCGGGCTGTGCGGGAGGTGGACTTCACCAAGAAACGGCTCCAGCAGGAGTTTGAGGACAAGCTGGAGGTGGAGCAGCAGAACAAGAGGC
AGCTGGAACGGCGGCTCGGGGACCTGCAGGCAGATAGTGAGGAGAGTCAGCGGGCTCTGCAGCAGCTCAAGAAGAAGTGCCAGCGACTGA
CGGCTGAGCTGCAAGACACCAAGCTGCACCTGGAGGGCCAGCAGGTCCGCAACCACGAACTGGAGAAGAAGCAGAGGAGGTTTGACAGTG
AGCTCTCGCAGGCGCATGAGGAGGCCCAGCGGGAGAAGCTGCAGCGGGAGAAGCTGCAGCGGGAGAAGGACATGCTCCTCGCTGAGGCTT
TCAGCCTGAAGCAGCAACTAGAGGAAAAAGACATGGACATTGCAGGGTTCACCCAGAAGGTTGTGTCTCTAGAGGCAGAGCTCCAGGACA
TTTCTTCCCAAGAGTCCAAGGATGAGGCTTCTCTGGCCAAGGTCAAGAAACAGCTCCGGGACCTGGAGGCCAAAGTCAAGGATCAGGAAG
AAGAGCTGGATGAGCAGGCAGGGACCATCCAGATGCTGGAACAGGCCAAGCTGCGTCTGGAGATGGAGATGGAGCGGATGAGACAGACCC
ATTCTAAGGAGATGGAGAGTCGGGATGAGGAGGTGGAGGAGGCCCGGCAGTCGTGTCAGAAGAAGTTAAAACAGATGGAGGTGCAGCTAG
AGGAAGAGTATGAGGACAAGCAGAAGGTTCTGCGAGAGAAGCGGGAGCTGGAGGGCAAGCTCGCCACCCTCAGCGACCAGGTGAACCGGC
GGGACTTTGAGTCAGAGAAGCGGCTGCGGAAGGACCTGAAGCGCACCAAGGCCCTGCTGGCAGATGCCCAGCTCATGCTGGACCACCTGA
AGAACAGTGCTCCCAGCAAGCGAGAGATTGCCCAGCTCAAGAACCAGCTGGAGGAGTCAGAGTTCACCTGTGCGGCAGCCGTGAAAGCAC
GGAAAGCAATGGAGGTGGAGATCGAAGACCTGCACCTGCAGATTGATGACATCGCCAAAGCCAAGACAGCGCTGGAGGAGCAGCTGAGCC
GCCTTCAGCGTGAGAAGAATGAGATCCAGAACCGGCTGGAGGAAGATCAGGAAGACATGAACGAATTGATGAAGAAGCACAAGGCTGCCG
TGGCTCAGGCTTCCCGGGACCTGGCTCAGATAAATGATCTCCAAGCTCAGCTAGAAGAAGCCAACAAAGAGAAGCAGGAGCTGCAGGAGA
AGCTACAAGCCCTCCAGAGCCAGGTGGAGTTCCTGGAGCAGTCCATGGTGGACAAGTCCCTGGTGAGCAGGCAGGAAGCTAAGATACGGG
AGCTGGAGACACGCCTGGAGTTTGAAAGGACGCAAGTGAAACGGCTGGAGAGCCTGGCTAGCCGTCTCAAGGAAAACATGGAGAAGCTGA
CTGAGGAGCGGGATCAGCGCATTGCAGCCGAGAACCGGGAGAAGGAACAGAACAAGCGGCTACAGAGGCAGCTCCGGGACACCAAGGAGG
AGATGGGCGAGCTTGCCAGGAAGGAGGCCGAGGCGAGCCGCAAGAAGCACGAACTGGAGATGGATCTAGAAAGCCTGGAGGCTGCTAACC
AGAGCCTGCAGGCTGACCTAAAGTTGGCATTCAAGCGCATCGGGGACCTGCAGGCTGCCATTGAGGATGAGATGGAGAGTGATGAGAATG
AGGACCTCATCAACAGTTTGCAGGACATGGTGACAAAGTATCAGAAAAGAAAGAATAAACTTGAGGGAGACTCTGATGTGGACTCGGAGC
TGGAGGACCGTGTTGACGGGGTCAAGTCCTGGTTGTCAAAAAACAAGGGACCTTCCAAGGCAGCTTCTGATGATGGCAGCTTAAAGAGTT
CCAGCCCCACCAGCTACTGGAAGTCCCTTGCCCCTGATCGGTCAGATGATGAGCACGACCCTCTCGACAACACCTCCAGACCGCGATACT
CCCACAGTTATCTGAGTGACAGCGACACAGAGGCCAAGCTGACGGAGACTAACGCATAGCCCAGGGGAGTGGTTGGCAGCCCTCTCACCC
CAGGGCCTGTGGCTGCCTGGGCACCTCTCCCAGGAAGTGGTGGGGCACCGGTCTCCCCCACCCGACTGCTGATCTGCATGGGAAACACCC
TGACCTTCTTCTGTCAGGGGCACTTTCCAGGCTATGGGTGTCTGATGTCTCCACGTGGAAGAGGTGGGGGAAAGAGGAGTTTCTGAAGAG
AACTTTTTGCTCCTCTGTCTCAAAATGCCAGACTCTTGGCTTCTACCCTGTGTCACCGTGGGCAGTGGCAGGTGGCCTGGCACTGCATGG
AGCCAGCACGTTGACCTCCCTCTCAGCTCCCTGCTCAGGGACGGTGGACAGGTTGCCTACTGGGACACTCTAGGTTGCTGGGTCCATGGG
GAGGATTGGGGGAGGAGAAGCAGTGCCTTCCCTCTCGTGTGGGGTGGGGGCTCTCTCTTCTTGGTGCCTGCTGTCTTTCTACTTTTTAAT
TTAAATACCCAACCTCTCCATCACAGCTGCATCCCTGAGAGTGGGAGGGGGCTGTAGTGGTAGCTGGGGCTCCCAAGAACGACTCGGGAA
TGTCATCTCCATCTTCACCCTTCAGAGAGCAGTCCTTTCTCTGTGCAGCTGGAGACGCTGGTGAGGAGAGCCGGGTCCAGGTTCTTAAGA
ATGAGGTGCGGAGGGGCTCTCCGGTGCTGCTGGGCTGGGTTGAGCAAGCCTACGCAGACAAGTGTGTGTGTGGACCATCCGCACCTCCAG
CCCCCACCCCACCCTCTTTGTCTCAGCGTGTTATGTGCAATGACCTATTTAAGGTAAACCCATTCCAACTACAGCAGTTCAGGGCTGATC
CAAGCACTGCCTCCCTCCTGCTCTGTCCAGGTGGTCTGGACCATAAACTCAACTTGAGAGGGAAGGCTTGGGGTTGAGGACTTGTGATCA
GAAAAACTGAAGATGGAAGTTTTGGCCGGTGCTCATTAGACATGAGTCCTCACTCTGTGTCCTGAGCCCGTGTCATTCTTCCAACCTCCC
TGCCCCCACACACTTATCCCAGACACAACACCATGTGGTCTGGAGGTCCCAGCCCCCACCCTAAAAAGGTTATCCCTGAGAACTCCACCA
GACTTGGGAGCCCAAGTGCAGTGCCTGGTGCTGCTCCCATCTGCCGCCCCCCTTCTCTCCTGCAATTGGTTTGTACTCACTGGGCTGTGC

>93105_93105_2_TOP3A-MYO18A_TOP3A_chr17_18202873_ENST00000321105_MYO18A_chr17_27430682_ENST00000354329_length(amino acids)=1286AA_BP=379
MKLQRPAGWWGRDRSEALVPFRWAPFEPHLWLPQDAPAAGERLRARGLRMIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAE
KNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKK
TLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRF
QTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATV
VEVRSKPKSKWRPQALDTVAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAI
RCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESA
SQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLE
VEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREK
DMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEME
MERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADA
QLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNEL
MKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRL
KENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIED
EMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPLD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TOP3A-MYO18A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TOP3A-MYO18A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TOP3A-MYO18A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource