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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TOP3B-MAPK1 (FusionGDB2 ID:93112)

Fusion Gene Summary for TOP3B-MAPK1

Fusion gene summary

Fusion gene information	Fusion gene name: TOP3B-MAPK1
	Fusion gene ID: 93112
		Hgene	Tgene
	Gene symbol	TOP3B	MAPK1
	Gene ID	8940	5594
	Gene name	DNA topoisomerase III beta	mitogen-activated protein kinase 1
	Synonyms	TOP3B1	ERK\|ERK-2\|ERK2\|ERT1\|MAPK2\|P42MAPK\|PRKM1\|PRKM2\|p38\|p40\|p41\|p41mapk\|p42-MAPK
	Cytomap	22q11.22	22q11.22
	Type of gene	protein-coding	protein-coding
	Description	DNA topoisomerase 3-beta-1DNA topoisomerase III beta-1topoisomerase (DNA) III betatopoisomerase III beta	mitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2
	Modification date	20200327	20200327
	UniProtAcc	.	Q8NDC0
	Ensembl transtripts involved in fusion gene	ENST00000357179, ENST00000398793, ENST00000413067,	ENST00000491588, ENST00000215832, ENST00000398822, ENST00000544786,
Fusion gene scores	* DoF score	3 X 3 X 3=27	15 X 8 X 9=1080
	# samples	3	16
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(16/1080*10)=-2.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TOP3B [Title/Abstract] AND MAPK1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MAPK1(22221612)-TOP3B(22313604), # samples:2 TOP3B(22328729)-MAPK1(22162135), # samples:2
Anticipated loss of major functional domain due to fusion event.	MAPK1-TOP3B seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. MAPK1-TOP3B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. MAPK1-TOP3B seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. TOP3B-MAPK1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. TOP3B-MAPK1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. TOP3B-MAPK1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MAPK1	GO:0006468	protein phosphorylation	23184662
Tgene	MAPK1	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	16314496
Tgene	MAPK1	GO:0018105	peptidyl-serine phosphorylation	15850461
Tgene	MAPK1	GO:0034198	cellular response to amino acid starvation	11096076
Tgene	MAPK1	GO:0038127	ERBB signaling pathway	15133037
Tgene	MAPK1	GO:0051403	stress-activated MAPK cascade	11096076
Tgene	MAPK1	GO:0070371	ERK1 and ERK2 cascade	16314496
Tgene	MAPK1	GO:0070849	response to epidermal growth factor	18794356

Fusion gene breakpoints across TOP3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MAPK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-61-2109-01A	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-

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Fusion Gene ORF analysis for TOP3B-MAPK1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000357179	ENST00000491588	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-
5CDS-intron	ENST00000398793	ENST00000491588	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-
5UTR-3CDS	ENST00000413067	ENST00000215832	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-
5UTR-3CDS	ENST00000413067	ENST00000398822	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-
5UTR-3CDS	ENST00000413067	ENST00000544786	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-
5UTR-intron	ENST00000413067	ENST00000491588	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-
Frame-shift	ENST00000357179	ENST00000215832	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-
Frame-shift	ENST00000398793	ENST00000398822	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-
Frame-shift	ENST00000398793	ENST00000544786	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-
In-frame	ENST00000357179	ENST00000398822	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-
In-frame	ENST00000357179	ENST00000544786	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-
In-frame	ENST00000398793	ENST00000215832	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000357179	TOP3B	chr22	22328729	-	ENST00000398822	MAPK1	chr22	22162135	-	1515	387	289	1350	353
ENST00000357179	TOP3B	chr22	22328729	-	ENST00000544786	MAPK1	chr22	22162135	-	1219	387	289	1218	310
ENST00000398793	TOP3B	chr22	22328729	-	ENST00000215832	MAPK1	chr22	22162135	-	11351	637	539	1600	353

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000357179	ENST00000398822	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-	0.002327856	0.99767214
ENST00000357179	ENST00000544786	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-	0.00253033	0.99746966
ENST00000398793	ENST00000215832	TOP3B	chr22	22328729	-	MAPK1	chr22	22162135	-	0.001106325	0.9988937

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Fusion Genomic Features for TOP3B-MAPK1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TOP3B-MAPK1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:22221612/chr22:22313604)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MAPK1 Q8NDC0
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000215832

259_277

3486.3333333333335

DNA binding

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000398822

259_277

361.0

DNA binding

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000544786

259_277

317.0

DNA binding

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000215832

185_187

3486.3333333333335

Motif

TXY

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000215832

318_322

3486.3333333333335

Motif

Cytoplasmic retention motif

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000215832

327_333

3486.3333333333335

Motif

Nuclear translocation motif

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000398822

185_187

361.0

Motif

TXY

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000398822

318_322

361.0

Motif

Cytoplasmic retention motif

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000398822

327_333

361.0

Motif

Nuclear translocation motif

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000544786

185_187

317.0

Motif

TXY

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000544786

318_322

317.0

Motif

Cytoplasmic retention motif

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000544786

327_333

317.0

Motif

Nuclear translocation motif

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000215832

105_108

3486.3333333333335

Region

Note=Inhibitor-binding

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000215832

153_154

3486.3333333333335

Region

Note=Inhibitor-binding

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000398822

105_108

361.0

Region

Note=Inhibitor-binding

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000398822

153_154

361.0

Region

Note=Inhibitor-binding

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000544786

105_108

317.0

Region

Note=Inhibitor-binding

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000544786

153_154

317.0

Region

Note=Inhibitor-binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TOP3B

chr22:22328729

chr22:22162135

ENST00000357179

3_153

863.0

Domain

Toprim

Hgene

TOP3B

chr22:22328729

chr22:22162135

ENST00000398793

3_153

863.0

Domain

Toprim

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000215832

2_9

3486.3333333333335

Compositional bias

Note=Poly-Ala

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000398822

2_9

361.0

Compositional bias

Note=Poly-Ala

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000544786

2_9

317.0

Compositional bias

Note=Poly-Ala

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000215832

25_313

3486.3333333333335

Domain

Protein kinase

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000398822

25_313

361.0

Domain

Protein kinase

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000544786

25_313

317.0

Domain

Protein kinase

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000215832

31_39

3486.3333333333335

Nucleotide binding

ATP

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000398822

31_39

361.0

Nucleotide binding

ATP

Tgene

MAPK1

chr22:22328729

chr22:22162135

ENST00000544786

31_39

317.0

Nucleotide binding

ATP

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Fusion Gene Sequence for TOP3B-MAPK1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>93112_93112_1_TOP3B-MAPK1_TOP3B_chr22_22328729_ENST00000357179_MAPK1_chr22_22162135_ENST00000398822_length(transcript)=1515nt_BP=387nt
GCCAGAAGCGGCTGGACCCGGAAATAGGGGTTGTCGGTAGCCGCCCCGGGAACAAGGACCGGAGCTGGATCCGCGGTGCGGCTGTGGGAG
TCAGCATTGGTAATAGTGCTGTGCTGCGGAAGAGTGGAGTCTAAACTTTTTCATTGCCAGTGCCCCGAAACTGGAGTGTGAAGGACCGAG
ACAAAATGAAGACTGTGCTCATGGTTGCTGAAAAGCCGTCCTTGGCACAGTCAATTGCCAAAATCCTCTCTAGAGGGAGCCTGTCCTCAC
ACAAAGGGCTGAACGGGGCCTGCTCAGTCCACGAGTACACTGGGACCTTTGCTGGCCAGCCAGTGCGCTTCAAGATGACGTCTGTCTGTG
GTCACGTGATGACCCTGGATTTCCTGGCTCTGCTTATGATAATGTCAACAAAGTTCGAGTAGCTATCAAGAAAATCAGCCCCTTTGAGCA
CCAGACCTACTGCCAGAGAACCCTGAGGGAGATAAAAATCTTACTGCGCTTCAGACATGAGAACATCATTGGAATCAATGACATTATTCG
AGCACCAACCATCGAGCAAATGAAAGATGTATATATAGTACAGGACCTCATGGAAACAGATCTTTACAAGCTCTTGAAGACACAACACCT
CAGCAATGACCATATCTGCTATTTTCTCTACCAGATCCTCAGAGGGTTAAAATATATCCATTCAGCTAACGTTCTGCACCGTGACCTCAA
GCCTTCCAACCTGCTGCTCAACACCACCTGTGATCTCAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACAC
AGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATAT
TTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTT
GGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGGAACTATTTGCTTTCTCTTCCACACAAAAA
TAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAG
GATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTT
CGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCTTA
AATTTGTCAGGTACCTGGAGTTTAATACAGTGAGCTCTAGCAAGGGAGGCGCTGCCTTTTGTTTCTAGAATATTATGTTCCTCAAGGTCC

>93112_93112_1_TOP3B-MAPK1_TOP3B_chr22_22328729_ENST00000357179_MAPK1_chr22_22162135_ENST00000398822_length(amino acids)=353AA_BP=1
MLSPRVHWDLCWPASALQDDVCLWSRDDPGFPGSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQ
MKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEY
VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNR

--------------------------------------------------------------
>93112_93112_2_TOP3B-MAPK1_TOP3B_chr22_22328729_ENST00000357179_MAPK1_chr22_22162135_ENST00000544786_length(transcript)=1219nt_BP=387nt
GCCAGAAGCGGCTGGACCCGGAAATAGGGGTTGTCGGTAGCCGCCCCGGGAACAAGGACCGGAGCTGGATCCGCGGTGCGGCTGTGGGAG
TCAGCATTGGTAATAGTGCTGTGCTGCGGAAGAGTGGAGTCTAAACTTTTTCATTGCCAGTGCCCCGAAACTGGAGTGTGAAGGACCGAG
ACAAAATGAAGACTGTGCTCATGGTTGCTGAAAAGCCGTCCTTGGCACAGTCAATTGCCAAAATCCTCTCTAGAGGGAGCCTGTCCTCAC
ACAAAGGGCTGAACGGGGCCTGCTCAGTCCACGAGTACACTGGGACCTTTGCTGGCCAGCCAGTGCGCTTCAAGATGACGTCTGTCTGTG
GTCACGTGATGACCCTGGATTTCCTGGCTCTGCTTATGATAATGTCAACAAAGTTCGAGTAGCTATCAAGAAAATCAGCCCCTTTGAGCA
CCAGACCTACTGCCAGAGAACCCTGAGGGAGATAAAAATCTTACTGCGCTTCAGACATGAGAACATCATTGGAATCAATGACATTATTCG
AGCACCAACCATCGAGCAAATGAAAGATGTATATATAGTACAGGACCTCATGGAAACAGATCTTTACAAGCTCTTGAAGACACAACACCT
CAGCAATGACCATATCTGCTATTTTCTCTACCAGATCCTCAGAGGGTTAAAATATATCCATTCAGCTAACGTTCTGCACCGTGACCTCAA
GCCTTCCAACCTGCTGCTCAACACCACCTGTGATCTCAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACAC
AGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATAT
TTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTT
GGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCA
GTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGA

>93112_93112_2_TOP3B-MAPK1_TOP3B_chr22_22328729_ENST00000357179_MAPK1_chr22_22162135_ENST00000544786_length(amino acids)=310AA_BP=1
MLSPRVHWDLCWPASALQDDVCLWSRDDPGFPGSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQ
MKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEY
VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD

--------------------------------------------------------------
>93112_93112_3_TOP3B-MAPK1_TOP3B_chr22_22328729_ENST00000398793_MAPK1_chr22_22162135_ENST00000215832_length(transcript)=11351nt_BP=637nt
GGATCCGCGGTGCGGCTGTGGGTGAGCGGCGGGCTGCGGGACCCTCGCCCGGCGGCTCAGAAAGGCGGGAAGCGCACGCATTTTTCTGGC
TTGTTTCCTGAACGTTGGCCGGCGGAGGACCCGCGAGCTCGGGAGAGCGCCCGGGCCGGGCTCTGCATTCTTGTTGCCTCTTCCCTGGCG
GGGGTGATACTCTCCCGCGGGGCTTGCTGTGGGGGTTCAGGGAGGTGGAGATGGGCCCGCCATGTGCCTGCAGGGAGCAGGCGCTGTGGT
TAATACTTTTCTTCTTCGAACCCTCCCACAGCTCTTTAGGGTGAGATCTGCTGTACCAGTCTCACAGGAGTCAGCATTGGTAATAGTGCT
GTGCTGCGGAAGAGTGGAGTCTAAACTTTTTCATTGCCAGTGCCCCGAAACTGGAGTGTGAAGGACCGAGACAAAATGAAGACTGTGCTC
ATGGTTGCTGAAAAGCCGTCCTTGGCACAGTCAATTGCCAAAATCCTCTCTAGAGGGAGCCTGTCCTCACACAAAGGGCTGAACGGGGCC
TGCTCAGTCCACGAGTACACTGGGACCTTTGCTGGCCAGCCAGTGCGCTTCAAGATGACGTCTGTCTGTGGTCACGTGATGACCCTGGAT
TTCCTGGCTCTGCTTATGATAATGTCAACAAAGTTCGAGTAGCTATCAAGAAAATCAGCCCCTTTGAGCACCAGACCTACTGCCAGAGAA
CCCTGAGGGAGATAAAAATCTTACTGCGCTTCAGACATGAGAACATCATTGGAATCAATGACATTATTCGAGCACCAACCATCGAGCAAA
TGAAAGATGTATATATAGTACAGGACCTCATGGAAACAGATCTTTACAAGCTCTTGAAGACACAACACCTCAGCAATGACCATATCTGCT
ATTTTCTCTACCAGATCCTCAGAGGGTTAAAATATATCCATTCAGCTAACGTTCTGCACCGTGACCTCAAGCCTTCCAACCTGCTGCTCA
ACACCACCTGTGATCTCAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATG
TGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTC
TGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCAT
CACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGC
TGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTC
TGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACT
TGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGACAAGGGCT
CAGAGGACTGGACGTGCTCAGACATCGGTGTTCTTCTTCCCAGTTCTTGACCCCTGGTCCTGTCTCCAGCCCGTCTTGGCTTATCCACTT
TGACTCCTTTGAGCCGTTTGGAGGGGCGGTTTCTGGTAGTTGTGGCTTTTATGCTTTCAAAGAATTTCTTCAGTCCAGAGAATTCCTCCT
GGCAGCCCTGTGTGTGTCACCCATTGGTGACCTGCGGCAGTATGTACTTCAGTGCACCTACTGCTTACTGTTGCTTTAGTCACTAATTGC
TTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAATCCTTTTCTACATGATGCCCTGCTGACCATGCAGCCGCACCAGAGAGAG
ATTCTTCCCCAATTGGCTCTAGTCACTGGCATCTCACTTTATGATAGGGAAGGCTACTACCTAGGGCACTTTAAGTCAGTGACAGCCCCT
TATTTGCACTTCACCTTTTGACCATAACTGTTTCCCCAGAGCAGGAGCTTGTGGAAATACCTTGGCTGATGTTGCAGCCTGCAGCAAGTG
CTTCCGTCTCCGGAATCCTTGGGGAGCACTTGTCCACGTCTTTTCTCATATCATGGTAGTCACTAACATATATAAGGTATGTGCTATTGG
CCCAGCTTTTAGAAAATGCAGTCATTTTTCTAAATAAAAAGGAAGTACTGCACCCAGCAGTGTCACTCTGTAGTTACTGTGGTCACTTGT
ACCATATAGAGGTGTAACACTTGTCAAGAAGCGTTATGTGCAGTACTTAATGTTTGTAAGACTTACAAAAAAAGATTTAAAGTGGCAGCT
TCACTCGACATTTGGTGAGAGAAGTACAAAGGTTGCAGTGCTGAGCTGTGGGCGGTTTCTGGGGATGTCCCAGGGTGGAACTCCACATGC
TGGTGCATATACGCCCTTGAGCTACTTCAAATGTGGGTGTTTCAGTAACCACGTTCCATGCCTGAGGATTTAGCAGAGAGGAACACTGCG
TCTTTAAATGAGAAAGTATACAATTCTTTTTCCTTCTACAGCATGTCAGCATCTCAAGTTCATTTTTCAACCTACAGTATAACAATTTGT
AATAAAGCCTCCAGGAGCTCATGACGTGAAGCACTGTTCTGTCCTCAAGTACTCAAATATTTCTGATACTGCTGAGTCAGACTGTCAGAA
AAAGCTAGCACTAACTCGTGTTTGGAGCTCTATCCATATTTTACTGATCTCTTTAAGTATTTGTTCCTGCCACTGTGTACTGTGGAGTTG
ACTCGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTTCCCCACTGCTCTCTGTGGTGAGAAATTTGCCTTGTTCAATAATTACTGTA
CCCTCGCATGACTGTTACAGCTTTCTGTGCAGAGATGACTGTCCAAGTGCCACATGCCTACGATTGAAATGAAAACTCTATTGTTACCTC
TGAGTTGTGTTCCACGGAAAATGCTATCCAGCAGATCATTTAGGAAAAATAATTCTATTTTTAGCTTTTCATTTCTCAGCTGTCCTTTTT
TCTTGTTTGATTTTTGACAGCAATGGAGAATGGGTTATATAAAGACTGCCTGCTAATATGAACAGAAATGCATTTGTAATTCATGAAAAT
AAATGTACATCTTCTATCTTCACATTCATGTTAAGATTCAGTGTTGCTTTCCTCTGGATCAGCGTGTCTGAATGGACAGTCAGGTTCAGG
TTGTGCTGAACACAGAAATGCTCACAGGCCTCACTTTGCCGCCCAGGCACTGGCCCAGCACTTGGATTTACATAAGATGAGTTAGAAAGG
TACTTCTGTAGGGTCCTTTTTACCTCTGCTCGGCAGAGAATCGATGCTGTCATGTTCCTTTATTCACAATCTTAGGTCTCAAATATTCTG
TCAAACCCTAACAAAGAAGCCCCGACATCTCAGGTTGGATTCCCTGGTTCTCTCTAAAGAGGGCCTGCCCTTGTGCCCCAGAGGTGCTGC
TGGGCACAGCCAAGAGTTGGGAAGGGCCGCCCCACAGTACGCAGTCCTCACCACCCAGCCCAGGGTGCTCACGCTCACCACTCCTGTGGC
TGAGGAAGGATAGCTGGCTCATCCTCGGAAAACAGACCCACATCTCTATTCTTGCCCTGAAATACGCGCTTTTCACTTGCGTGCTCAGAG
CTGCCGTCTGAAGGTCCACACAGCATTGACGGGACACAGAAATGTGACTGTTACCGGATAACACTGATTAGTCAGTTTTCATTTATAAAA
AAGCATTGACAGTTTTATTACTCTTGTTTCTTTTTAAATGGAAAGTTACTATTATAAGGTTAATTTGGAGTCCTCTTCTAAATAGAAAAC
CATATCCTTGGCTACTAACATCTGGAGACTGTGAGCTCCTTCCCATTCCCCTTCCTGGTACTGTGGAGTCAGATTGGCATGAAACCACTA
ACTTCATTCTAGAATCATTGTAGCCATAAGTTGTGTGCTTTTTATTAATCATGCCAAACATAATGTAACTGGGCAGAGAATGGTCCTAAC
CAAGGTACCTATGAAAAGCGCTAGCTATCATGTGTAGTAGATGCATCATTTTGGCTCTTCTTACATTTGTAAAAATGTACAGATTAGGTC
ATCTTAATTCATATTAGTGACACGGAACAGCACCTCCACTATTTGTATGTTCAAATAAGCTTTCAGACTAATAGCTTTTTTGGTGTCTAA
AATGTAAGCAAAAAATTCCTGCTGAAACATTCCAGTCCTTTCATTTAGTATAAAAGAAATACTGAACAAGCCAGTGGGATGGAATTGAAA
GAACTAATCATGAGGACTCTGTCCTGACACAGGTCCTCAAAGCTAGCAGAGATACGCAGACATTGTGGCATCTGGGTAGAAGAATACTGT
ATTGTGTGTGCAGTGCACAGTGTGTGGTGTGTGCACACTCATTCCTTCTGCTCTTGGGCACAGGCAGTGGGTGTAGAGGTAACCAGTAGC
TTTGAGAAGCTACATGTAGCTCACCAGTGGTTTTCTCTAAGGAATCACAAAAGTAAACTACCCAACCACATGCCACGTAATATTTCAGCC
ATTCAGAGGAAACTGTTTTCTCTTTATTTGCTTATATGTTAATATGGTTTTTAAATTGGTAACTTTTATATAGTATGGTAACAGTATGTT
AATACACACATACATACGCACACATGCTTTGGGTCCTTCCATAATACTTTTATATTTGTAAATCAATGTTTTGGAGCAATCCCAAGTTTA
AGGGAAATATTTTTGTAAATGTAATGGTTTTGAAAATCTGAGCAATCCTTTTGCTTATACATTTTTAAAGCATTTGTGCTTTAAAATTGT
TATGCTGGTGTTTGAAACATGATACTCCTGTGGTGCAGATGAGAAGCTATAACAGTGAATATGTGGTTTCTCTTACGTCATCCACCTTGA
CATGATGGGTCAGAAACAAATGGAAATCCAGAGCAAGTCCTCCAGGGTTGCACCAGGTTTACCTAAAGCTTGTTGCCTTTTCTTGTGCTG
TTTATGCGTGTAGAGCACTCAAGAAAGTTCTGAAACTGCTTTGTATCTGCTTTGTACTGTTGGTGCCTTCTTGGTATTGTACCCCAAAAT
TCTGCATAGATTATTTAGTATAATGGTAAGTTAAAAAATGTTAAAGGAAGATTTTATTAAGAATCTGAATGTTTATTCATTATATTGTTA
CAATTTAACATTAACATTTATTTGTGGTATTTGTGATTTGGTTAATCTGTATAAAAATTGTAAGTAGAAAGGTTTATATTTCATCTTAAT
TCTTTTGATGTTGTAAACGTACTTTTTAAAAGATGGATTATTTGAATGTTTATGGCACCTGACTTGTAAAAAAAAAAAACTACAAAAAAA
TCCTTAGAATCATTAAATTGTGTCCCTGTATTACCAAAATAACACAGCACCGTGCATGTATAGTTTAATTGCAGTTTCATCTGTGAAAAC
GTGAAATTGTCTAGTCCTTCGTTATGTTCCCCAGATGTCTTCCAGATTTGCTCTGCATGTGGTAACTTGTGTTAGGGCTGTGAGCTGTTC
CTCGAGTTGAATGGGGATGTCAGTGCTCCTAGGGTTCTCCAGGTGGTTCTTCAGACCTTCACCTGTGGGGGGGGGGGTAGGCGGTGCCCA
CGCCCATCTCCTCATCCTCCTGAACTTCTGCAACCCCACTGCTGGGCAGACATCCTGGGCAACCCCTTTTTTCAGAGCAAGAAGTCATAA
AGATAGGATTTCTTGGACATTTGGTTCTTATCAATATTGGGCATTATGTAATGACTTATTTACAAAACAAAGATACTGGAAAATGTTTTG
GATGTGGTGTTATGGAAAGAGCACAGGCCTTGGACCCATCCAGCTGGGTTCAGAACTACCCCCTGCTTATAACTGCGGCTGGCTGTGGGC
CAGTCATTCTGCGTCTCTGCTTTCTTCCTCTGCTTCAGACTGTCAGCTGTAAAGTGGAAGCAATATTACTTGCCTTGTATATGGTAAAGA
TTATAAAAATACATTTCAACTGTTCAGCATAGTACTTCAAAGCAAGTACTCAGTAAATAGCAAGTCTTTTTAAATGCTGCTTTATTTCAC
TAAATTTTGTTGTGAGGTGTCACTAAAATGCCTGCAAACAAACGTAACTGCTAATCTGAGAGGAAACCCTCTTACTAATCAGAGAAGAAA
CCCTCCTGTCAGAAACCTTCAGGGAAGTGAGCTGATCACACCTAAACTGGGAGTTTGCAATGGGGTATTTGAAGCACTGTGGGAGTATTC
CACTGGCCCTCTCCCTGAGAGACTTAACAGTCTTCCCTGTTGTCCAGATTCTGTATAAGGCAATCAGAATAATCATCTTCCTTGTTCAGC
AGAGGAGCCTGGTCCCATTTTCCCCACTTTGTGATGGGCTTCTCTCAGCGGTAGCTCAGCAGTTCCAGATGGCAGTTTGGACCAGCATCT
AGGCTGGCCAGTTCGCTGTGTTTACTTAGAACCAACACGTTCAGAGCTGGCCTGGACCATCTGAGGGGAACAGGAAACACCCCTAGGCTG
TGGAAGCAAGTGCAGACCCCCACCCCCGGCCCTGAAGCCAAGGGGGCAGGGTTTGGGAGTGGCCAAAGAGAAGCAGTGCAGGGATGGGTT
TTCCTAGGGACAGGCTTAGCATTCCTGACTCTAGGAAGAAGGAGCAGTGAGGCGGAGAAACAGTGGAGGGGATGGTGGCATTGGGCCCCA
TGGGGCCGAGATGGACACAGGGCTCGTTCTCTTGAGTCTGGTGCCAAGGACAGCTGAAGACGACATCATTTTCAGGTGGAGAGGAGAGAG
TGGAGGGAGATCATGCCCTGTGATGTGTCTTTTGCAGGTGAAGGTGGGAGACAAGGTCTCTGCTGACGATGAGGCAGAGCCACCGTGAAA
GTTGTAATAGGAGGACTGCCCGCCGCTGGAAGGGCCTGCAGTGACGCTAGGACACCCTCTGCCTGCATGTCACGTTAGCTGGGCTGGGCG
AAGTAGAAGACCAAGGGGAAGAGGTGCAGTGGGGAGACCAGGTGGGATGCAACCACAGGACCAGTGGAGGGGCTGTGGCACGTGGGCGGA
GACTGAGTGGCTGGGCATGTGTTGTGGCTGAGCATGTGGTGTGGGCAGTGGTCCTAGACCCCGCCATGTCCGGACAATGATATAGAGCGT
CTCAGCATCGCCAGTCTAGACTGTCTATGGAGAGCAGAAAGTTGTCTGGGGCTGCCTGGGGAACTGTGAGGCCAGCTATATCACCGTCGC
TGATGGTGACATTACGGTGGTGGCAGGAGCAAGGAGAGAGGGAAGAAGGACCCCGTCCAGCTTTAGTCACAAAATACCCAATGGAAGATG
CCAGTGCCAATCCTGTGGGTTTCCTTGGGACTTCACACTGGCTTTCTTATCTGCTCCAGATCCATTCAGTAGTCACTGAGTTCCTGCCAA
ATACTTTGTAGCGCCAGAAGCCAGGAGCGGGGTCTGCAGCAGGGCAGTCCCCATTTTCAGGAAATGCCTGGAGCTGCTGGTCCCTGAGAG
AAAGGAAAACATCTTTCAGCCGTACGCAGGCCAAGAAGGCCAATGTCCAGTAGCTTTGTGATTTTTTTTATATTTTTTTATTTATTTATT
TTTGAGATAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCAGTGGCGTGATCTCCACTCACTGCAACTTCCGCCTCCTGGGGTCAAGCAG
TTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACACGCCACCACACCCAGCTAATTTTTGTGTTTTTAGTAGAGACGGTTTCACC
ATGTCGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCCAGC
CTGTGATGTTTCTGTGGGGTTCCACAAATGTGTGTGTGTGTAAAAGCTGATGATTACAGCAAGAATGTGAACAGTAGCAGTTTTCCATTT
GAAGGCAAGTTTTGTCTTTATCTGGGTATCAGAAGGACCCTCTGGGCCATTGTCGCTTCCTGTACTCAGAGCCACCCTAGTACTACGGGC
ACACACAGAAAACAGCAGCCTGCGTACTTTCAAAGGAAAGGCATCTTTAATCACCAATGCCTGGAAAAATTATTTTGTTTCCCTCTTCCT
TCCGTCTTGTTTCCTAACTTCTTACCAAAGTTTAGAGTCTGAGTTTTTCGTATAATAATGTCCCACATCCACACATCGGGCCTACAGATG
CTCTCCCTTGAATCGACTGGAAACATGACACCGGTTCCATGCTCTGGAACTGTCACCTGTGATGTGCTGGGCTGTGTCCCAAGCACAGGA
ATCCCAGCAGTTTCAGCTCGATGCAGAACCACCATGCTCCAGACACAGGCTTGGGAAAGACACGTCAAAATTAAAATACTAGGTAAGAGA
AGCACCTGATTGGGTAGAAGTTGGAGAGGAATCCTGGAATTTTGTGGCCAGAAGGAGCCACTGCCCCTTTTGTTTAGTAAGACTAGACAG
TAACAGAAGCCAGTTGTCAGCTATGAAAGTGGTGGGTGAAGCAGGGGAGGCTCCTCTATGGTGGGACCCTGGACAAGGGAAGCCGAATGT
GTGAAGAAGGGGTGCGGGGGTGTGCGGTGCCCTAGGACACTAGGGCAAAGGTTTCAAACCTGGAACAAGGCACTGGAGGAAGATCTGCTG
CCAGTCAGCAGTGCGGGCCCTCGAGTTAGCAGTCCGTGCGCAGAGGGGCCAGTTCTGAGACCAGTTTGGAGAGTCAGGCAGTGACCCATT
GGCCATGTCATAATTCCTTCAGCCTGCCTCCTCTTTAATCCCAGAGAGTGCTCTTTCTTCATACTTCCTTTAAAATACTAAATTGTTCCC
ATTCCATGGGGAGCTGGCTAGGCTTTACAGGCTAGGAAATGTAGGTTTTCTGAGATGGAACCATCTACACAAGGAGGAGGAAGGCACTAA
GACTACAGATGAGACCCATGACAGGGCTGAGCATTTGGAAGCCAACCCTGGTTGCTTTTCAAGAATTGCTTTGTGGCTGGGTGCAGTGGT
TCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGCAGGTGGATTGCTTGAACCCAGGAGTTCGAGACCAGCCTGGGCAACATATGGGA
CACCCCACCGCCCCCGGCTCTGCAAAAAAATTAAAAATTAGCCAGGCGTGGTGTCATGAGCCTGTGGTCTCAACTACTCAGGAGGCTGAG
GCTGGAGGATCGCTTGAACCTGGGAGGTCAAGGCTCCAGTGAACCATAATTGTGCCACTGCACTGCAGCCTGGGCGACAATTTGTTTTCT
AAATTGCTTTTGAAAGTCTACTGCATTACATATTCCAAAAAGCAGTGGTTTTCAAATACTTTTATCACCGATATCCTTTTATGAAATGAA
ATCAGTAGAACTTTCTCTGCTCTGAATAAGCAAGGGTGGGAACCTGTCTACCTCCCACAGATAGCATAATGTGCCTGCCATAGAGGAGCC
AAAAAATGGTGATGGGAACTGAGAGGAGAGCAAATGTCACAAAAGACTGAGCAATTGAGAAAACAAAACAAGACCACAGATGACTGTTAA
CGCCTCCACAGTGGACCAAGAAAGGACAGAGAGCTGGCAGCATGGGCATCACTGTCTGGTCGGCAGCAGGAAGGCCTCGCTAGGGAATTG
AGTACAGTCATCTAACTAGTTTAAAAGTACAGGAAGGATGATTAAGGCTATTGGAGAGGTCATACAAATAGGGGAGGGGCAGGCAATGGC
TGATAAGACATGAATTTGTAAGGCGATGAGTATTGCAGTCAGCAAAACAAACGAGACTGCTCTCCCAACACATAACTCAGCAGGGAGGCC
AGGCATTGGTTTAACCATTTAATATAAAGAAGTTAAAATTACAAATGCGCTAAGTGCCTAAAGAAGAATAAGTGCAGGAATGAGAGCAGC
ATGGACTGCCACAGTTTTAGAATAAGCACTGTCACTGCTAGATTGGAAACAAAAATCCATAAATTTGGCCCGGTGTGGTGGCGGACGCCT
GTAGTCCCAGCTACTTGGAGGCTGAGGCGTGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATGGCGCCACTGCACT
CCAGCCTGGGCGTCAGAGTGAGAACTCTGTATCAAAAAATAAAAATAAAAAAAAGTCCATAAATCTGCAATGTCTCAGTTAAGAAAGAAA
GACTGGGCCAATGCAGATTTCAAACCGGAGAAAGTCATACTGTCAGTGAAGGCCGCCTGTGGCCGGAAGGCGCCAGGGGATTAGCACCCT
GGACTCAGTGTTGCTGGGAAACAGGGCCCCAAGGCTGGGAGCACAGTGTTTAAAGGGCATCTACCCAAGAAGGGAGCACAGGGCAAGGAG
GAGCTGCAGGGGGGCTTGGCTGCCAAAGTGAATTCTGAGGAGAGAGCTATTGCTGCCTACGATATGCAGGCTGCACAGAACACAAGTGGA
ATCAGCAGGCAGGAGAGGCAGCTAACGACGCAGCCCGTTTCTTATTTCTGTTTTCTCACAAGCGATGAAAGTGGAAAAGAGGGTGAGCAG
GTGGCCCACACATGTGCCTCCAGTGCTGCGGCCCCTCCGGGGACCATCAGCCAGGCCCCGGGGAGGGAGCCAGCCACAGTGTGTCCGGCT
CTTCTCTGAAGGGAAGAGAGCCTTGAATAGACTGAAGCGAAGACGGTTCTGCAAGGACAAGGCAGACCGAAGGCATTGGTTTTTTTTTTC
AGATAAGGAGAATTAGACTCCCAAGTAGACACCAGAGTCACTGTTTGGTTGGTGGGTGATAGTGGGGTCACAGTGGCTGCCTGTGCTCCC
CCAGGGTGAGCGTGACTGTGCTAACCTGGGTGGGGCAGCATGCACACCCCTCTGGCAGCCCTTTGTTGCTCGCTGATGACAAGTTTGGAT
GATCCCGCCAAACAGCTTGCTAAGATGTAGTCCCCAGTGTTGGAGGTGGGGCCTGATGGGAGGTGCTACCCTTGTGAGATAAGGTTGTGT
AAAAGCCTGTGGCACCTCCCCACACTGACGCTCTCACCCCTGCTCTGGCCATGTGCCGCGCCTGCTCCCACTTCCCCTTCTGCCAGGAGT
AAAAGCCCCCGAGACCTCCCAGAAGCCAAGCAGATGCTAGTGCCATGCTTCCTCTGCAGCCTGCAGAACTGTGAGCCAATTAAACCTCTT

>93112_93112_3_TOP3B-MAPK1_TOP3B_chr22_22328729_ENST00000398793_MAPK1_chr22_22162135_ENST00000215832_length(amino acids)=353AA_BP=1
MLSPRVHWDLCWPASALQDDVCLWSRDDPGFPGSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQ
MKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEY
VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TOP3B-MAPK1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TOP3B-MAPK1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TOP3B-MAPK1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source