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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TOX-CHD7 (FusionGDB2 ID:93171)

Fusion Gene Summary for TOX-CHD7

check button Fusion gene summary
Fusion gene informationFusion gene name: TOX-CHD7
Fusion gene ID: 93171
HgeneTgene
Gene symbol

TOX

CHD7

Gene ID

9760

55636

Gene namethymocyte selection associated high mobility group boxchromodomain helicase DNA binding protein 7
SynonymsTOX1CRG|HH5|IS3|KAL5
Cytomap

8q12.1

8q12.2

Type of geneprotein-codingprotein-coding
Descriptionthymocyte selection-associated high mobility group box protein TOXthymus high mobility group box protein TOXchromodomain-helicase-DNA-binding protein 7ATP-dependent helicase CHD7CHARGE associationchromodomain helicase DNA binding protein 7 isoform CRA_e
Modification date2020031320200328
UniProtAcc

TOX4

Q9P2D1

Ensembl transtripts involved in fusion geneENST00000361421, ENST00000529472, 
ENST00000423902, ENST00000524602, 
ENST00000525508, 
Fusion gene scores* DoF score8 X 6 X 6=2889 X 5 X 6=270
# samples 89
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TOX [Title/Abstract] AND CHD7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHD7(61655656)-TOX(59872567), # samples:9
TOX(60031445)-CHD7(61693559), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TOX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CHD7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-4T-AA8H-01ATOXchr8

60031445

-CHD7chr8

61693559

+


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Fusion Gene ORF analysis for TOX-CHD7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000361421ENST00000529472TOXchr8

60031445

-CHD7chr8

61693559

+
In-frameENST00000361421ENST00000423902TOXchr8

60031445

-CHD7chr8

61693559

+
In-frameENST00000361421ENST00000524602TOXchr8

60031445

-CHD7chr8

61693559

+
In-frameENST00000361421ENST00000525508TOXchr8

60031445

-CHD7chr8

61693559

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361421TOXchr860031445-ENST00000423902CHD7chr861693559+862532322176512476
ENST00000361421TOXchr860031445-ENST00000524602CHD7chr861693559+20463232211504427
ENST00000361421TOXchr860031445-ENST00000525508CHD7chr861693559+34353232212074617

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361421ENST00000423902TOXchr860031445-CHD7chr861693559+0.0005676820.99943227
ENST00000361421ENST00000524602TOXchr860031445-CHD7chr861693559+0.0006178130.99938214
ENST00000361421ENST00000525508TOXchr860031445-CHD7chr861693559+0.0005076020.9994924

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Fusion Genomic Features for TOX-CHD7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TOXchr860031444-CHD7chr861693558+0.0321537780.9678463
TOXchr860031444-CHD7chr861693558+0.0321537780.9678463

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TOX-CHD7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:61655656/chr8:59872567)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TOX

TOX4

CHD7

Q9P2D1

621FUNCTION: Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCHD7chr8:60031445chr8:61693559ENST000004239021382401_24315552998.0Coiled coilOntology_term=ECO:0000255
TgeneCHD7chr8:60031445chr8:61693559ENST00000524602052401_2431555949.0Coiled coilOntology_term=ECO:0000255
TgeneCHD7chr8:60031445chr8:61693559ENST000005255080122401_24315551139.0Coiled coilOntology_term=ECO:0000255
TgeneCHD7chr8:60031445chr8:61693559ENST000004239021381939_19455552998.0Compositional biasNote=Poly-Arg
TgeneCHD7chr8:60031445chr8:61693559ENST000004239021382165_22585552998.0Compositional biasNote=Glu-rich
TgeneCHD7chr8:60031445chr8:61693559ENST000004239021382398_24055552998.0Compositional biasNote=Poly-Arg
TgeneCHD7chr8:60031445chr8:61693559ENST000004239021382726_27365552998.0Compositional biasNote=Poly-Ala
TgeneCHD7chr8:60031445chr8:61693559ENST00000423902138597_7185552998.0Compositional biasNote=Lys-rich
TgeneCHD7chr8:60031445chr8:61693559ENST00000524602051939_1945555949.0Compositional biasNote=Poly-Arg
TgeneCHD7chr8:60031445chr8:61693559ENST00000524602052165_2258555949.0Compositional biasNote=Glu-rich
TgeneCHD7chr8:60031445chr8:61693559ENST00000524602052398_2405555949.0Compositional biasNote=Poly-Arg
TgeneCHD7chr8:60031445chr8:61693559ENST00000524602052726_2736555949.0Compositional biasNote=Poly-Ala
TgeneCHD7chr8:60031445chr8:61693559ENST0000052460205597_718555949.0Compositional biasNote=Lys-rich
TgeneCHD7chr8:60031445chr8:61693559ENST000005255080121939_19455551139.0Compositional biasNote=Poly-Arg
TgeneCHD7chr8:60031445chr8:61693559ENST000005255080122165_22585551139.0Compositional biasNote=Glu-rich
TgeneCHD7chr8:60031445chr8:61693559ENST000005255080122398_24055551139.0Compositional biasNote=Poly-Arg
TgeneCHD7chr8:60031445chr8:61693559ENST000005255080122726_27365551139.0Compositional biasNote=Poly-Ala
TgeneCHD7chr8:60031445chr8:61693559ENST00000525508012597_7185551139.0Compositional biasNote=Lys-rich
TgeneCHD7chr8:60031445chr8:61693559ENST000004239021381294_14645552998.0DomainHelicase C-terminal
TgeneCHD7chr8:60031445chr8:61693559ENST00000423902138800_8675552998.0DomainChromo 1
TgeneCHD7chr8:60031445chr8:61693559ENST00000423902138882_9475552998.0DomainChromo 2
TgeneCHD7chr8:60031445chr8:61693559ENST00000423902138980_11545552998.0DomainHelicase ATP-binding
TgeneCHD7chr8:60031445chr8:61693559ENST00000524602051294_1464555949.0DomainHelicase C-terminal
TgeneCHD7chr8:60031445chr8:61693559ENST0000052460205800_867555949.0DomainChromo 1
TgeneCHD7chr8:60031445chr8:61693559ENST0000052460205882_947555949.0DomainChromo 2
TgeneCHD7chr8:60031445chr8:61693559ENST0000052460205980_1154555949.0DomainHelicase ATP-binding
TgeneCHD7chr8:60031445chr8:61693559ENST000005255080121294_14645551139.0DomainHelicase C-terminal
TgeneCHD7chr8:60031445chr8:61693559ENST00000525508012800_8675551139.0DomainChromo 1
TgeneCHD7chr8:60031445chr8:61693559ENST00000525508012882_9475551139.0DomainChromo 2
TgeneCHD7chr8:60031445chr8:61693559ENST00000525508012980_11545551139.0DomainHelicase ATP-binding
TgeneCHD7chr8:60031445chr8:61693559ENST000004239021381105_11085552998.0MotifNote=DEAH box
TgeneCHD7chr8:60031445chr8:61693559ENST00000524602051105_1108555949.0MotifNote=DEAH box
TgeneCHD7chr8:60031445chr8:61693559ENST000005255080121105_11085551139.0MotifNote=DEAH box
TgeneCHD7chr8:60031445chr8:61693559ENST00000423902138993_10005552998.0Nucleotide bindingATP
TgeneCHD7chr8:60031445chr8:61693559ENST0000052460205993_1000555949.0Nucleotide bindingATP
TgeneCHD7chr8:60031445chr8:61693559ENST00000525508012993_10005551139.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTOXchr8:60031445chr8:61693559ENST00000361421-19417_42034527.0Compositional biasNote=Poly-Pro
HgeneTOXchr8:60031445chr8:61693559ENST00000361421-19261_32934527.0DNA bindingHMG box
HgeneTOXchr8:60031445chr8:61693559ENST00000361421-19237_25634527.0MotifNuclear localization signal
TgeneCHD7chr8:60031445chr8:61693559ENST00000423902138151_2225552998.0Compositional biasNote=Gln-rich
TgeneCHD7chr8:60031445chr8:61693559ENST00000423902138383_5685552998.0Compositional biasNote=Pro-rich
TgeneCHD7chr8:60031445chr8:61693559ENST0000052460205151_222555949.0Compositional biasNote=Gln-rich
TgeneCHD7chr8:60031445chr8:61693559ENST0000052460205383_568555949.0Compositional biasNote=Pro-rich
TgeneCHD7chr8:60031445chr8:61693559ENST00000525508012151_2225551139.0Compositional biasNote=Gln-rich
TgeneCHD7chr8:60031445chr8:61693559ENST00000525508012383_5685551139.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for TOX-CHD7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93171_93171_1_TOX-CHD7_TOX_chr8_60031445_ENST00000361421_CHD7_chr8_61693559_ENST00000423902_length(transcript)=8625nt_BP=323nt
GGTGCGCGCCGCGGCTTGGGGGAGAGTTGAGCGCTTTTCCCCCCTCTTTTTTTTTTTTTTCCTCTTCTTCTTAAACAAACCACAAACGGA
TGTGAGGGAAGGAAGGTGTTTCTTTTACTCCTGAGCCCAGACACCTCACTCTGTTCCGTCTAAGCTTGTTTTGCTGAACACTTTTTTTTA
AAAAAGGAAAAAGAAAAGGAGTTGCTTGATGTGAGAGTGAAATGGACGTAAGATTTTATCCACCTCCAGCCCAGCCCGCCGCTGCGCCCG
ACGCTCCCTGTCTGGGACCTTCTCCCTGCCTGGACCCCTACTATTGCAACAAGCATTCCCCGTCGGAGCCCTTTCTAGAGAAACCAGTGC
CGGATATGACTCAGGTTAGTGGACCGAATGCTCAGCTAGTGAAGAGTGATGATTACCTGCCATCAATAGAACAGCAGCCACAACAAAAGA
AGAAGAAAAAGAAAAACAACCACATTGTAGCAGAGGATCCCAGTAAAGGTTTTGGTAAAGATGACTTCCCTGGTGGGGTAGATAACCAAG
AACTAAATAGGAACTCACTGGATGGGTCCCAAGAAGAAAAAAAGAAAAAGAAAAGGTCAAAGGCAAAAAAAGACCCGAAGGAACCGAAAG
AACCCAAGGAGAAAAAAGAGCCCAAGGAACCCAAGACCCCGAAAGCCCCTAAGATTCCCAAAGAGCCAAAGGAAAAGAAAGCAAAAACTG
CCACGCCAAAACCCAAATCCAGCAAAAAGTCAAGTAATAAGAAACCTGACTCAGAAGCAAGTGCTTTGAAGAAAAAGGTCAACAAGGGAA
AAACAGAAGGTTCTGAAAATTCAGACTTAGACAAAACACCCCCACCATCTCCTCCTCCTGAAGAAGATGAGGACCCAGGTGTTCAGAAGA
GACGGTCCAGCAGACAGGTGAAGAGAAAGCGCTACACTGAAGACCTGGAGTTCAAGATTTCTGATGAGGAGGCAGATGATGCAGATGCTG
CTGGGAGGGATTCCCCCTCCAACACCTCCCAGTCAGAACAGCAGGAATCTGTTGATGCAGAAGGCCCAGTGGTAGAAAAAATTATGAGCA
GTCGTTCAGTAAAAAAGCAGAAGGAATCTGGAGAGGAGGTAGAAATTGAGGAATTCTATGTGAAATACAAAAACTTCTCTTATCTTCATT
GTCAGTGGGCATCTATAGAAGATCTGGAAAAAGATAAGAGAATTCAGCAAAAAATTAAACGATTTAAGGCAAAGCAGGGCCAGAACAAGT
TCCTTTCAGAGATTGAGGATGAGCTTTTTAATCCAGATTATGTGGAGGTTGACCGGATAATGGACTTTGCACGTAGCACAGATGACCGGG
GAGAGCCTGTGACTCACTATCTGGTGAAGTGGTGTTCACTTCCTTATGAAGACAGCACGTGGGAGCGGAGGCAGGACATAGATCAAGCAA
AGATCGAGGAGTTTGAGAAACTAATGTCCAGGGAGCCGGAAACAGAGCGTGTGGAGCGACCTCCTGCTGATGATTGGAAGAAATCGGAGA
GTTCCAGGGAGTATAAAAACAATAACAAACTCAGGGAATACCAGTTGGAGGGAGTAAACTGGCTACTTTTCAATTGGTACAACATGCGAA
ACTGCATTTTAGCAGATGAAATGGGTTTGGGAAAAACTATCCAGTCCATTACATTTCTCTATGAGATATATTTGAAAGGAATCCATGGCC
CTTTTTTAGTAATTGCCCCATTGTCCACAATCCCCAACTGGGAAAGGGAATTCCGAACCTGGACAGAGTTGAACGTGGTTGTGTATCATG
GGAGTCAAGCTAGTCGTCGGACCATTCAGTTGTATGAAATGTACTTCAAAGATCCCCAGGGTCGAGTGATAAAGGGGTCCTATAAGTTTC
ATGCCATCATCACTACATTTGAGATGATTTTGACTGATTGTCCTGAGCTGCGGAATATTCCATGGCGCTGTGTAGTCATTGATGAAGCCC
ACAGGCTGAAGAACAGGAACTGCAAGCTGTTGGAGGGACTCAAGATGATGGACTTGGAACACAAAGTGCTGCTGACGGGAACCCCACTCC
AGAACACTGTGGAAGAACTCTTCAGCTTGCTTCATTTCTTGGAACCAAGTCGCTTCCCTTCAGAAACCACATTTATGCAAGAATTTGGTG
ATCTAAAAACAGAAGAGCAGGTGCAAAAACTTCAAGCTATTCTAAAGCCAATGATGTTGAGACGTCTCAAAGAGGATGTAGAAAAGAACT
TGGCCCCCAAAGAAGAAACTATTATTGAAGTTGAGCTAACAAACATTCAGAAGAAATATTACCGAGCCATCCTTGAGAAGAATTTCACAT
TTCTTTCCAAAGGCGGTGGTCAAGCTAACGTACCTAACCTATTAAACACTATGATGGAATTGCGGAAGTGCTGCAATCATCCGTACCTTA
TCAATGGTGCTGAAGAGAAAATTTTGGAAGAGTTTAAAGAAACACACAATGCAGAGTCTCCAGATTTTCAGCTCCAGGCAATGATCCAGG
CTGCTGGCAAGCTAGTGCTGATTGACAAGCTGCTGCCAAAACTGAAGGCTGGTGGCCACAGGGTGCTTATCTTTTCCCAGATGGTGCGCT
GCTTGGACATACTGGAAGACTACCTCATTCAAAGACGGTACCCATATGAAAGGATCGACGGCCGAGTAAGAGGCAACCTCCGCCAGGCAG
CTATCGACAGATTCTCCAAACCTGATTCTGATAGGTTTGTTTTCCTCCTGTGTACAAGGGCAGGAGGTTTAGGCATTAACCTCACTGCTG
CTGATACCTGCATCATCTTTGATTCAGACTGGAATCCCCAAAATGACCTCCAGGCTCAGGCTAGATGTCATAGAATAGGACAGAGCAAAT
CTGTGAAAATCTACAGGCTGATTACAAGAAATTCCTATGAAAGGGAAATGTTCGACAAGGCTAGTTTGAAACTGGGCCTGGATAAAGCTG
TGCTACAGTCTATGAGTGGAAGAGAAAATGCTACCAATGGGGTACAACAGCTTTCCAAGAAAGAAATAGAGGATCTTCTACGAAAAGGGG
CCTATGGTGCACTCATGGATGAGGAGGATGAAGGGTCTAAATTCTGTGAAGAAGATATTGATCAGATCCTCCTACGTCGAACCCACACCA
TTACCATTGAGTCAGAAGGGAAAGGTTCCACATTTGCTAAGGCCAGTTTTGTTGCATCTGGAAATAGGACAGATATTTCCTTGGATGATC
CAAATTTCTGGCAAAAGTGGGCTAAGAAGGCTGAATTGGATATTGATGCCTTAAATGGGAGGAACAACCTGGTTATTGATACTCCAAGAG
TGAGAAAGCAGACCAGGCTCTACAGTGCAGTGAAGGAAGATGAGCTGATGGAGTTCTCAGACTTGGAAAGTGATTCTGAAGAAAAGCCCT
GTGCAAAGCCACGGCGTCCCCAGGATAAGTCACAGGGCTATGCAAGGAGTGAATGTTTCAGGGTGGAGAAGAATCTGCTTGTCTATGGTT
GGGGACGGTGGACAGACATTCTTTCCCACGGACGCTATAAACGCCAACTCACTGAGCAAGATGTAGAAACCATCTGCAGAACCATCCTGG
TGTACTGTCTTAATCATTACAAAGGGGATGAGAATATCAAAAGCTTCATCTGGGATCTGATCACACCCACAGCGGATGGCCAGACTCGAG
CCTTGGTCAACCATTCCGGTTTGTCAGCTCCTGTGCCAAGGGGAAGGAAGGGAAAGAAGGTGAAAGCCCAGAGCACACAGCCGGTGGTGC
AGGATGCCGACTGGCTGGCCAGCTGCAACCCAGATGCCCTGTTCCAGGAGGACAGCTACAAGAAACACCTGAAGCATCACTGTAACAAGG
TCCTGCTGCGTGTCCGCATGCTGTACTACCTAAGACAAGAAGTGATAGGAGACCAGGCGGATAAGATCTTAGAGGGTGCTGACTCAAGTG
AAGCCGATGTGTGGATCCCTGAACCTTTCCATGCTGAAGTTCCTGCAGATTGGTGGGATAAGGAAGCAGACAAATCCCTCTTAATTGGAG
TGTTCAAACATGGCTATGAGAAGTACAACTCCATGCGAGCTGACCCCGCGCTGTGCTTTCTGGAACGAGTCGGTATGCCTGATGCCAAGG
CCATAGCTGCCGAGCAAAGAGGAACAGACATGCTAGCAGATGGTGGTGACGGGGGAGAATTTGATAGAGAAGATGAAGACCCAGAATATA
AACCAACCAGAACACCGTTCAAAGATGAAATAGATGAATTTGCAAATTCTCCTTCAGAGGATAAGGAAGAATCCATGGAAATACATGCCA
CAGGCAAGCACAGTGAGAGTAATGCTGAGTTAGGCCAACTTTACTGGCCTAACACTTCAACCCTGACTACACGTCTGCGCCGGCTCATTA
CTGCCTATCAGCGCAGCTATAAAAGGCAACAGATGAGGCAAGAGGCCCTAATGAAGACTGACCGGCGCAGACGGCGGCCTCGAGAGGAAG
TGAGAGCTCTGGAAGCGGAAAGGGAAGCTATTATATCTGAGAAGCGGCAAAAGTGGACAAGAAGAGAAGAGGCTGATTTTTACCGTGTGG
TATCCACCTTTGGGGTTATTTTTGACCCTGTGAAACAGCAATTTGACTGGAACCAATTTAGAGCCTTTGCCAGGCTTGACAAAAAATCTG
ATGAGAGTTTGGAGAAATACTTCAGTTGTTTTGTGGCCATGTGTAGGCGAGTATGTCGAATGCCCGTCAAGCCAGATGATGAACCGCCCG
ACCTCTCCTCCATAATTGAGCCGATCACAGAGGAGCGAGCCTCTCGAACTCTGTACCGCATTGAGCTGCTACGGAAGATCCGCGAGCAGG
TTCTCCATCACCCCCAGCTGGGAGAGAGGCTTAAGCTCTGCCAGCCAAGCTTGGATCTGCCAGAGTGGTGGGAGTGTGGACGGCATGACC
GAGACTTGCTGGTTGGTGCTGCTAAACACGGGGTCAGTCGGACGGATTATCACATCCTCAATGACCCTGAGTTATCCTTCTTGGATGCAC
ATAAAAACTTTGCTCAAAACAGAGGGGCAGGTAATACATCTTCCTTGAACCCACTGGCAGTTGGATTTGTCCAGACTCCTCCAGTCATCT
CATCTGCTCATATTCAAGATGAGAGGGTACTGGAACAAGCCGAAGGCAAAGTGGAGGAGCCTGAAAACCCAGCTGCCAAGGAGAAATGTG
AGGGCAAAGAAGAGGAAGAAGAAACCGATGGCAGCGGGAAGGAGAGCAAGCAGGAATGTGAGGCAGAGGCCAGCTCTGTGAAAAATGAAC
TGAAAGGTGTTGAGGTCGGCGCAGACACTGGGTCCAAATCTATTTCAGAGAAAGGTTCCGAAGAGGATGAAGAGGAAAAGCTGGAGGATG
ACGATAAGTCGGAAGAGTCTTCCCAGCCCGAAGCAGGAGCTGTCTCTAGAGGGAAGAATTTTGATGAAGAAAGCAATGCTTCCATGAGCA
CTGCTAGAGATGAAACCCGAGATGGATTCTACATGGAGGACGGAGATCCTTCAGTAGCTCAGCTCCTTCATGAAAGAACATTTGCCTTCT
CGTTTTGGCCTAAGGATAGAGTAATGATAAACCGCTTAGACAACATCTGTGAAGCAGTGTTGAAAGGCAAATGGCCAGTAAATAGGCGCC
AGATGTTTGATTTCCAAGGCCTCATCCCAGGTTACACACCCACCACAGTGGACAGCCCCTTGCAGAAGAGGAGCTTTGCTGAGCTCTCCA
TGGTCGGCCAAGCCAGCATTAGTGGGAGTGAGGACATCACTACGTCTCCTCAGTTGTCAAAGGAAGATGCCCTCAACCTCTCTGTCCCTC
GCCAGCGGAGGAGGAGGAGGAGAAAAATCGAAATTGAGGCCGAAAGAGCTGCCAAGAGGCGAAATCTCATGGAGATGGTTGCCCAGCTTC
GAGAGTCTCAGGTGGTCTCAGAAAATGGACAAGAAAAAGTTGTAGATTTATCAAAGGCCTCAAGAGAGGCAACAAGCTCTACCTCAAATT
TTTCATCTCTTTCTTCAAAGTTTATCTTGCCTAATGTCTCAACACCAGTGTCTGATGCCTTTAAGACTCAAATGGAACTGCTCCAAGCAG
GCCTTTCGCGCACACCCACAAGGCATCTCCTTAATGGCTCCCTAGTGGATGGAGAGCCTCCCATGAAGAGGAGGCGGGGAAGGAGGAAAA
ATGTGGAGGGACTTGATCTGCTTTTCATGAGCCACAAACGGACGTCATTGAGTGCAGAGGATGCTGAGGTGACCAAAGCTTTTGAAGAAG
ATATAGAGACCCCACCAACAAGAAACATTCCTTCTCCCGGACAGCTGGACCCAGACACACGGATCCCTGTTATCAATCTTGAAGATGGGA
CTAGGCTGGTGGGGGAAGATGCTCCTAAAAATAAGGATTTAGTTGAATGGCTGAAGCTGCACCCTACTTACACTGTTGATATGCCAAGTT
ATGTACCAAAGAATGCAGATGTGCTGTTTTCCTCATTTCAGAAACCGAAACAGAAACGACATAGATGTCGAAACCCTAATAAATTGGATA
TAAACACTTTGACAGGAGAAGAAAGGGTGCCTGTTGTCAATAAACGAAATGGGAAGAAGATGGGTGGAGCTATGGCGCCTCCAATGAAGG
ATCTACCCAGGTGGCTGGAAGAAAATCCTGAATTTGCAGTTGCTCCAGACTGGACTGATATAGTTAAGCAGTCTGGTTTTGTTCCTGAGT
CGATGTTTGACCGCCTTCTCACTGGGCCTGTAGTGCGGGGAGAGGGAGCGAGCAGAAGAGGAAGAAGGCCCAAAAGTGAGATCGCCAGAG
CAGCCGCGGCCGCCGCTGCTGTGGCCTCCACGTCAGGGATCAACCCTTTGCTGGTGAACAGCCTGTTTGCTGGAATGGACCTGACGAGCC
TTCAGAATCTCCAGAATCTCCAGTCGCTCCAGCTGGCAGGCCTCATGGGCTTCCCTCCAGGACTGGCAACAGCTGCCACCGCCGGAGGCG
ATGCGAAGAACCCTGCTGCTGTGCTGCCCCTGATGCTGCCAGGAATGGCGGGCCTGCCCAACGTGTTTGGCTTGGGCGGGCTGTTGAATA
ACCCTCTGTCAGCTGCTACTGGAAACACCACTACTGCTTCTAGTCAAGGAGAACCGGAAGACAGCACTTCAAAAGGAGAGGAGAAAGGAA
ATGAGAATGAAGACGAGAACAAAGACTCTGAGAAAAGCACAGATGCTGTTTCGGCTGCTGACTCTGCGAATGGATCTGTTGGTGCTGCTA
CTGCCCCGGCTGGATTGCCCTCAAACCCGCTAGCCTTCAACCCTTTCCTCCTGTCCACAATGGCCCCGGGCCTCTTCTACCCATCCATGT
TTCTACCTCCAGGACTGGGGGGATTGACGCTGCCTGGGTTCCCAGCATTGGCAGGACTTCAGAATGCCGTGGGCTCCAGCGAAGAAAAGG
CTGCTGACAAGGCTGAGGGAGGACCCTTTAAAGATGGAGAGACCCTTGAAGGCAGCGATGCCGAGGAGAGCCTGGATAAGACTGCAGAGT
CCTCCCTCTTAGAAGACGAAATAGCACAGGGTGAAGAGCTAGACTCACTTGATGGGGGGGATGAAATAGAAAACAATGAAAATGATGAAT
AACCAGTACCAGTTCCAGTTCAAGTGTTTAAAACTTTTGACAAGTGGTAGTCCTACTGTTTACACTCACAGTTAATGTTCATACCTAGTT
TTATAAGCTGTTCTGTAACATAGTGTAGCAAAAAAAAAAGTTCAAGTCATGTTATACAGGTGTGTCAAAAGGTATCTTGGTCATTAAGTA
TTGTGCAGTGCATTATTTATTATCCCTAGGAGAGATGAAATTTGAGAGGTGATCATGTCTTTTTAAGGAAACTTACATAATGCTCTGCTT
TTTTTTTTTCTCTTGGTACCATTGGTATTATAATAAAGAGCAATTTGTAACTGAGTGGCACTAATGGAAGAAAGTGCTGCTCAAAGGAAG
TATGAAGTTATATATTTAATTTTTTAATTTTAATTTTTAATTTTTTTGCTGTGAAGGTCAAGCTGAAATTTACCATACATATCATACTTG
CTCATTTGTTTCCCTTTTTGACTGTATGGGGGTTCCCACACTCGTGCATACACACACATCCATACACTCTGACAATCTCCACGCTAGTGT
GAACGCCTCTGTCCCGAGGCGCAGCAATAATAAGGCAGCTGTTGAATGTGAAGGGTCCCTTTGGAAAATTAACCTACTGGGAGGGTTCTT
GCCAGACAGAACTACAGTTCCATTGTCTCGTGGTCTTGTAATGCACTGGTAAAAACAAAATAAATAGATGAATAAATAAAGAGTGAGAGA
AGAGAGAATCAGGTACCTTTTTTAAATTAAAGGACTTTGTTACTTTAGCCACAAAGCTAAAACAGCATTACCTCAGCTCTAAACTAGCCT
TGAAGTTTACAGACATGACTTTGTAAATGTATTGTTTTTCTTTGTTGTGATGTCCTTTTATTTTTTTCTTTGAAAACTGCTATCATGTAA

>93171_93171_1_TOX-CHD7_TOX_chr8_60031445_ENST00000361421_CHD7_chr8_61693559_ENST00000423902_length(amino acids)=2476AA_BP=119
MDVRFYPPPAQPAAAPDAPCLGPSPCLDPYYCNKHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKKKKNNHIVAEDP
SKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPKEKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNK
KPDSEASALKKKVNKGKTEGSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGRDSPSNTSQSEQ
QESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQWASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDY
VEVDRIMDFARSTDDRGEPVTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSREYKNNNKLREY
QLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEM
YFKDPQGRVIKGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFL
EPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNL
LNTMMELRKCCNHPYLINGAEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILEDYLIQRRY
PYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYE
REMFDKASLKLGLDKAVLQSMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITIESEGKGSTFAK
ASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRKQTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGY
ARSECFRVEKNLLVYGWGRWTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALVNHSGLSAPVPR
GRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNKVLLRVRMLYYLRQEVIGDQADKILEGADSSEADVWIPEPFHAEV
PADWWDKEADKSLLIGVFKHGYEKYNSMRADPALCFLERVGMPDAKAIAAEQRGTDMLADGGDGGEFDREDEDPEYKPTRTPFKDEIDEF
ANSPSEDKEESMEIHATGKHSESNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPREEVRALEAEREAIISE
KRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDESLEKYFSCFVAMCRRVCRMPVKPDDEPPDLSSIIEPITEERA
SRTLYRIELLRKIREQVLHHPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFLDAHKNFAQNRGAGNTS
SLNPLAVGFVQTPPVISSAHIQDERVLEQAEGKVEEPENPAAKEKCEGKEEEEETDGSGKESKQECEAEASSVKNELKGVEVGADTGSKS
ISEKGSEEDEEEKLEDDDKSEESSQPEAGAVSRGKNFDEESNASMSTARDETRDGFYMEDGDPSVAQLLHERTFAFSFWPKDRVMINRLD
NICEAVLKGKWPVNRRQMFDFQGLIPGYTPTTVDSPLQKRSFAELSMVGQASISGSEDITTSPQLSKEDALNLSVPRQRRRRRRKIEIEA
ERAAKRRNLMEMVAQLRESQVVSENGQEKVVDLSKASREATSSTSNFSSLSSKFILPNVSTPVSDAFKTQMELLQAGLSRTPTRHLLNGS
LVDGEPPMKRRRGRRKNVEGLDLLFMSHKRTSLSAEDAEVTKAFEEDIETPPTRNIPSPGQLDPDTRIPVINLEDGTRLVGEDAPKNKDL
VEWLKLHPTYTVDMPSYVPKNADVLFSSFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLPRWLEENPEFAV
APDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAAAAAAVASTSGINPLLVNSLFAGMDLTSLQNLQNLQSLQLAG
LMGFPPGLATAATAGGDAKNPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDSTSKGEEKGNENEDENKDSEKST
DAVSAADSANGSVGAATAPAGLPSNPLAFNPFLLSTMAPGLFYPSMFLPPGLGGLTLPGFPALAGLQNAVGSSEEKAADKAEGGPFKDGE

--------------------------------------------------------------
>93171_93171_2_TOX-CHD7_TOX_chr8_60031445_ENST00000361421_CHD7_chr8_61693559_ENST00000524602_length(transcript)=2046nt_BP=323nt
GGTGCGCGCCGCGGCTTGGGGGAGAGTTGAGCGCTTTTCCCCCCTCTTTTTTTTTTTTTTCCTCTTCTTCTTAAACAAACCACAAACGGA
TGTGAGGGAAGGAAGGTGTTTCTTTTACTCCTGAGCCCAGACACCTCACTCTGTTCCGTCTAAGCTTGTTTTGCTGAACACTTTTTTTTA
AAAAAGGAAAAAGAAAAGGAGTTGCTTGATGTGAGAGTGAAATGGACGTAAGATTTTATCCACCTCCAGCCCAGCCCGCCGCTGCGCCCG
ACGCTCCCTGTCTGGGACCTTCTCCCTGCCTGGACCCCTACTATTGCAACAAGCATTCCCCGTCGGAGCCCTTTCTAGAGAAACCAGTGC
CGGATATGACTCAGAAACCGAAACAGAAACGACATAGATGTCGAAACCCTAATAAATTGGATATAAACACTTTGACAGGAGAAGAAAGGG
TGCCTGTTGTCAATAAACGAAATGGGAAGAAGATGGGTGGAGCTATGGCGCCTCCAATGAAGGATCTACCCAGGTGGCTGGAAGAAAATC
CTGAATTTGCAGTTGCTCCAGACTGGACTGATATAGTTAAGCAGTCTGGTTTTGTTCCTGAGTCGATGTTTGACCGCCTTCTCACTGGGC
CTGTAGTGCGGGGAGAGGGAGCGAGCAGAAGAGGAAGAAGGCCCAAAAGTGAGATCGCCAGAGCAGCCGCGGCCGCCGCTGCTGTGGCCT
CCACGTCAGGGATCAACCCTTTGCTGGTGAACAGCCTGTTTGCTGGAATGGACCTGACGAGCCTTCAGAATCTCCAGAATCTCCAGTCGC
TCCAGCTGGCAGGCCTCATGGGCTTCCCTCCAGGACTGGCAACAGCTGCCACCGCCGGAGGCGATGCGAAGAACCCTGCTGCTGTGCTGC
CCCTGATGCTGCCAGGAATGGCGGGCCTGCCCAACGTGTTTGGCTTGGGCGGGCTGTTGAATAACCCTCTGTCAGCTGCTACTGGAAACA
CCACTACTGCTTCTAGTCAAGGAGAACCGGAAGACAGCACTTCAAAAGGAGAGGAGAAAGGAAATGAGAATGAAGACGAGAACAAAGACT
CTGAGAAAAGCACAGATGCTGTTTCGGCTGCTGACTCTGCGAATGGATCTGTTGGTGCTGCTACTGCCCCGGCTGGATTGCCCTCAAACC
CGCTAGCCTTCAACCCTTTCCTCCTGTCCACAATGGCCCCGGGCCTCTTCTACCCATCCATGTTTCTACCTCCAGGACTGGGGGGATTGA
CGCTGCCTGGGTTCCCAGCATTGGCAGGACTTCAGAATGCCGTGGGCTCCAGCGAAGAAAAGGCTGCTGACAAGGCTGAGGGAGGACCCT
TTAAAGATGGAGAGACCCTTGAAGGCAGCGATGCCGAGGAGAGCCTGGATAAGACTGCAGAGTCCTCCCTCTTAGAAGACGAAATAGCAC
AGGGTGAAGAGCTAGACTCACTTGATGGGGGGGATGAAATAGAAAACAATGAAAATGATGAATAACCAGTACCAGTTCCAGTTCAAGTGT
TTAAAACTTTTGACAAGTGGTAGTCCTACTGTTTACACTCACAGTTAATGTTCATACCTAGTTTTATAAGCTGTTCTGTAACATAGTGTA
GCAAAAAAAAAAGTTCAAGTCATGTTATACAGGTGTGTCAAAAGGTATCTTGGTCATTAAGTATTGTGCAGTGCATTATTTATTATCCCT
AGGAGAGATGAAATTTGAGAGGTGATCATGTCTTTTTAAGGAAACTTACATAATGCTCTGCTTTTTTTTTTTCTCTTGGTACCATTGGTA
TTATAATAAAGAGCAATTTGTAACTGAGTGGCACTAATGGAAGAAAGTGCTGCTCAAAGGAAGTATGAAGTTATATATTTAATTTTTTAA
TTTTAATTTTTAATTTTTTTGCTGTGAAGGTCAAGCTGAAATTTACCATACATATCATACTTGCTCATTTGTTTCCCTTTTTGACTGTAT

>93171_93171_2_TOX-CHD7_TOX_chr8_60031445_ENST00000361421_CHD7_chr8_61693559_ENST00000524602_length(amino acids)=427AA_BP=34
MDVRFYPPPAQPAAAPDAPCLGPSPCLDPYYCNKHSPSEPFLEKPVPDMTQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGG
AMAPPMKDLPRWLEENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAAAAAAVASTSGINPLLVNSLF
AGMDLTSLQNLQNLQSLQLAGLMGFPPGLATAATAGGDAKNPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDST
SKGEEKGNENEDENKDSEKSTDAVSAADSANGSVGAATAPAGLPSNPLAFNPFLLSTMAPGLFYPSMFLPPGLGGLTLPGFPALAGLQNA

--------------------------------------------------------------
>93171_93171_3_TOX-CHD7_TOX_chr8_60031445_ENST00000361421_CHD7_chr8_61693559_ENST00000525508_length(transcript)=3435nt_BP=323nt
GGTGCGCGCCGCGGCTTGGGGGAGAGTTGAGCGCTTTTCCCCCCTCTTTTTTTTTTTTTTCCTCTTCTTCTTAAACAAACCACAAACGGA
TGTGAGGGAAGGAAGGTGTTTCTTTTACTCCTGAGCCCAGACACCTCACTCTGTTCCGTCTAAGCTTGTTTTGCTGAACACTTTTTTTTA
AAAAAGGAAAAAGAAAAGGAGTTGCTTGATGTGAGAGTGAAATGGACGTAAGATTTTATCCACCTCCAGCCCAGCCCGCCGCTGCGCCCG
ACGCTCCCTGTCTGGGACCTTCTCCCTGCCTGGACCCCTACTATTGCAACAAGCATTCCCCGTCGGAGCCCTTTCTAGAGAAACCAGTGC
CGGATATGACTCAGGTTAGTGGACCGAATGCTCAGCTAGTGAAGAGTGATGATTACCTGCCATCAATAGAACAGCAGCCACAACAAAAGA
AGAAGAAAAAGAAAAACAACCACATTGTAGCAGAGGATCCCAGTAAAGGTTTTGGTAAAGATGACTTCCCTGGTGGGGTAGATAACCAAG
AACTAAATAGGAACTCACTGGATGGGTCCCAAGAAGAAAAAAAGAAAAAGAAAAGGTCAAAGGCAAAAAAAGACCCGAAGGAACCGAAAG
AACCCAAGGAGAAAAAAGAGCCCAAGGAACCCAAGACCCCGAAAGCCCCTAAGATTCCCAAAGAGCCAAAGGAAAAGAAAGCAAAAACTG
CCACGCCAAAACCCAAATCCAGCAAAAAGTCAAGTAATAAGAAACCTGACTCAGAAGCAAGTGCTTTGAAGAAAAAGGTCAACAAGGGAA
AAACAGAAGGTTCTGAAAATTCAGACTTAGACAAAACACCCCCACCATCTCCTCCTCCTGAAGAAGATGAGGACCCAGGTGTTCAGAAGA
GACGGTCCAGCAGACAGGTGAAGAGAAAGCGCTACACTGAAGACCTGGAGTTCAAGATTTCTGATGAGGAGGCAGATGATGCAGATGCTG
CTGGGAGGGATTCCCCCTCCAACACCTCCCAGTCAGAACAGCAGGAATCTGTTGATGCAGAAGGCCCAGTGGTAGAAAAAATTATGAGCA
GTCGTTCAGTAAAAAAGCAGAAGGAATCTGGAGAGGAGGTAGAAATTGAGGAATTCTATGTGAAATACAAAAACTTCTCTTATCTTCATT
GTCAGTGGGCATCTATAGAAGATCTGGAAAAAGATAAGAGAATTCAGCAAAAAATTAAACGATTTAAGGCAAAGCAGGGCCAGAACAAGT
TCCTTTCAGAGATTGAGGATGAGCTTTTTAATCCAGATTATGTGGAGGTTGACCGGATAATGGACTTTGCACGTAGCACAGATGACCGGG
GAGAGCCTGTGACTCACTATCTGGTGAAGTGGTGTTCACTTCCTTATGAAGACAGCACGTGGGAGCGGAGGCAGGACATAGATCAAGCAA
AGATCGAGGAGTTTGAGAAACTAATGTCCAGGGAGCCGGAAACAGAGCGTGTGGAGCGACCTCCTGCTGATGATTGGAAGAAATCGGAGA
GTTCCAGGGAGTATAAAAACAATAACAAACTCAGGGAATACCAGTTGGAGGGAGTAAACTGGCTACTTTTCAATTGGTACAACATGCGAA
ACTGCATTTTAGCAGATGAAATGGGTTTGGGAAAAACTATCCAGTCCATTACATTTCTCTATGAGATATATTTGAAAGGAATCCATGGCC
CTTTTTTAGTAATTGCCCCATTGTCCACAATCCCCAACTGGGAAAGGGAATTCCGAACCTGGACAGAGTTGAACGTGGTTGTGTATCATG
GGAGTCAAGCTAGTCGTCGGACCATTCAGTTGTATGAAATGTACTTCAAAGATCCCCAGGGTCGAGTGATAAAGGGGTCCTATAAGTTTC
ATGCCATCATCACTACATTTGAGATGATTTTGACTGATTGTCCTGAGCTGCGGAATATTCCATGGCGCTGTGTAGTCATTGATGAAGCCC
ACAGGCTGAAGAACAGGAACTGCAAGCTGTTGGAGGGACTCAAGATGATGGACTTGGTCAGTGACCATATTGGTGATTGCACTGAACCTG
AATAGAATTGTTGCTGACTTGATAGTCCCGTTGCTCAGAATTTGATGCCTGTAAACAGTATTTGAAAAGCTTGTCAAATATTGTGATATA
TTCTCTGGCACTTTCAGTTATTCAAAAGTTGTTGCCTTTTGGATTCTTACATTGTTGGCTAGTGTCTGTTAAACAGTTGTATTATAGCAG
AGTGTAATCATGATAGTTTCACTAAAGTGAGTTTCAAGTATTTGTTTTACCCTTTGTTCATAAATACAGGTTGATCATACCAAATACAAA
AATCCCAGAATCCAAAACGTTTTGAGTACCCACATAATGCTAAAAGGAAATGCTCATTGGAGCATTTTGGATTTTGGATTTTCTCATTTG
GGATGTTCAACCCGTAAGTATAAATGCAGATATTCCAAAATCTAAAAATATCTGAAATCTGAAACACTCTGGTCCCAAGAATTTTGGATA
AGGGATACTTAACCTGTACTGCCATTTCATTAACTGTTGGGCCAAGCTTTACTTCAGTGATGATAGTCCAGTTATTTTTCAGTGCTCATA
GGTTTTGCCATACTGTGGCCAGCAGGACTTGTAGATGCAAGTTCTCAATGAGTTGGGTAGGATATCTGGGGTTGGTTTAGTTCGCACAGA
TGCTTAGAAGTTTGGGGCATTACAGTGCCTCAGATTTGATCTGGAGTTTTACACCACACTTATCCCATAGTCTTCCAGCTTCCCAAGAGA
TGATCAGGTCTTCCTGATTAGATTTTCTAGATTTTTTTTTCAGCAGGAGCATCATGGAATAACATATCGTAGGAGTAGAAGGATTTGATT
TATTTTCTGTCTGATACTGCTGTGTGTGATTTCCTAGTGGGAATTGCAACATGACCTGTCATCCTCAGGCTTCTTTTCACTCCATAGTTT
ATATAGTGGTTATGATCACTTATATTTTATTTTTAATGTACATTTGGAAAGCAAAGCTCCTGTCATTTAGCATGCCTTGGATGATTTGAT
GAGTTTCACGGAAGTACAAAAAGGGTTTCAAAGTATTTTTAATGCTAATTTCTGCAGGCTAATTTGATCTTTTGTTAACTGAGAGTTTGA
GATGAGAAGGAGTGTTCTGTATATTCATGGCCATATGTTTTTAGCTGAAGACTGGTATTACCAAAAAACACCTAAAAGCTTTTTGTTGCA
GCTGATTCTCTGAAAGAGCAGCTTATTTTATTCTTAAAGAGATTAGAATTGCCAGCTATGCTTTTAGTTTAAAACAAACAAAATCTAGTT
TTGCTTAAAGGAAAAAGTCTGACTGAATTATCCTATTTAGGGTGGGATTTCCCATTTTTCTTCCTAATGAATTATTATTAAAGCGATCCT

>93171_93171_3_TOX-CHD7_TOX_chr8_60031445_ENST00000361421_CHD7_chr8_61693559_ENST00000525508_length(amino acids)=617AA_BP=119
MDVRFYPPPAQPAAAPDAPCLGPSPCLDPYYCNKHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKKKKNNHIVAEDP
SKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPKEKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNK
KPDSEASALKKKVNKGKTEGSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGRDSPSNTSQSEQ
QESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQWASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDY
VEVDRIMDFARSTDDRGEPVTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSREYKNNNKLREY
QLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TOX-CHD7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TOX-CHD7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TOX-CHD7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource