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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TP53-PXDNL (FusionGDB2 ID:93236)

Fusion Gene Summary for TP53-PXDNL

check button Fusion gene summary
Fusion gene informationFusion gene name: TP53-PXDNL
Fusion gene ID: 93236
HgeneTgene
Gene symbol

TP53

PXDNL

Gene ID

7157

137902

Gene nametumor protein p53peroxidasin like
SynonymsBCC7|BMFS5|LFS1|P53|TRP53PMR1|PRM1|VPO2
Cytomap

17p13.1

8q11.22-q11.23

Type of geneprotein-codingprotein-coding
Descriptioncellular tumor antigen p53antigen NY-CO-13mutant tumor protein 53p53 tumor suppressorphosphoprotein p53transformation-related protein 53tumor protein 53tumor supressor p53peroxidasin-like proteincardiac peroxidasecardiovascular peroxidase 2peroxidasin homolog-likepolysomal ribonuclease 1 homologvascular peroxidase 2
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000269305, ENST00000359597, 
ENST00000413465, ENST00000420246, 
ENST00000445888, ENST00000455263, 
ENST00000574684, 		ENST00000356297, 
ENST00000543296, 
Fusion gene scores* DoF score30 X 19 X 10=57007 X 5 X 8=280
# samples 379
** MAII scorelog2(37/5700*10)=-3.94536474342315
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TP53 [Title/Abstract] AND PXDNL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTP53(7577499)-PXDNL(52567320), # samples:1
Anticipated loss of major functional domain due to fusion event.TP53-PXDNL seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TP53-PXDNL seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TP53-PXDNL seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TP53-PXDNL seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TP53-PXDNL seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TP53-PXDNL seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
TP53-PXDNL seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTP53

GO:0000733

DNA strand renaturation

8183576

HgeneTP53

GO:0006355

regulation of transcription, DNA-templated

7587074

HgeneTP53

GO:0006974

cellular response to DNA damage stimulus

14744935|15710329|17938203

HgeneTP53

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

16213212

HgeneTP53

GO:0006983

ER overload response

14744935

HgeneTP53

GO:0007050

cell cycle arrest

15149599

HgeneTP53

GO:0008104

protein localization

16507995

HgeneTP53

GO:0008285

negative regulation of cell proliferation

22783376

HgeneTP53

GO:0010628

positive regulation of gene expression

15314173|20332243

HgeneTP53

GO:0030330

DNA damage response, signal transduction by p53 class mediator

15149599

HgeneTP53

GO:0031497

chromatin assembly

16322561

HgeneTP53

GO:0034644

cellular response to UV

16213212|23629966

HgeneTP53

GO:0036003

positive regulation of transcription from RNA polymerase II promoter in response to stress

30089260

HgeneTP53

GO:0042149

cellular response to glucose starvation

14744935|21471221

HgeneTP53

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

14654789|14744935|17403783

HgeneTP53

GO:0042981

regulation of apoptotic process

14744935

HgeneTP53

GO:0043065

positive regulation of apoptotic process

12667443|15565177|20959462

HgeneTP53

GO:0045892

negative regulation of transcription, DNA-templated

24051492

HgeneTP53

GO:0045893

positive regulation of transcription, DNA-templated

16322561|17403783|18549481|20378837

HgeneTP53

GO:0045899

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

24289924

HgeneTP53

GO:0045944

positive regulation of transcription by RNA polymerase II

11672523|17145718|17310983|17599062|18549481|20959462|24652652

HgeneTP53

GO:0051123

RNA polymerase II preinitiation complex assembly

24289924

HgeneTP53

GO:0051974

negative regulation of telomerase activity

10597287

HgeneTP53

GO:0065003

protein-containing complex assembly

12915590

HgeneTP53

GO:0071158

positive regulation of cell cycle arrest

15314173

HgeneTP53

GO:0071480

cellular response to gamma radiation

16213212

HgeneTP53

GO:0072331

signal transduction by p53 class mediator

15314173

HgeneTP53

GO:0072717

cellular response to actinomycin D

15314173

HgeneTP53

GO:0090200

positive regulation of release of cytochrome c from mitochondria

14963330

HgeneTP53

GO:0097252

oligodendrocyte apoptotic process

7720704

HgeneTP53

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

20546595

HgeneTP53

GO:1903800

positive regulation of production of miRNAs involved in gene silencing by miRNA

26100857

HgeneTP53

GO:1990248

regulation of transcription from RNA polymerase II promoter in response to DNA damage

30089260


check buttonFusion gene breakpoints across TP53 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PXDNL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A7EF-01ATP53chr17

7577499

-PXDNLchr8

52567320

-


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Fusion Gene ORF analysis for TP53-PXDNL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000269305ENST00000356297TP53chr17

7577499

-PXDNLchr8

52567320

-
Frame-shiftENST00000359597ENST00000543296TP53chr17

7577499

-PXDNLchr8

52567320

-
Frame-shiftENST00000413465ENST00000543296TP53chr17

7577499

-PXDNLchr8

52567320

-
Frame-shiftENST00000420246ENST00000543296TP53chr17

7577499

-PXDNLchr8

52567320

-
Frame-shiftENST00000445888ENST00000356297TP53chr17

7577499

-PXDNLchr8

52567320

-
Frame-shiftENST00000455263ENST00000543296TP53chr17

7577499

-PXDNLchr8

52567320

-
In-frameENST00000269305ENST00000543296TP53chr17

7577499

-PXDNLchr8

52567320

-
In-frameENST00000359597ENST00000356297TP53chr17

7577499

-PXDNLchr8

52567320

-
In-frameENST00000413465ENST00000356297TP53chr17

7577499

-PXDNLchr8

52567320

-
In-frameENST00000420246ENST00000356297TP53chr17

7577499

-PXDNLchr8

52567320

-
In-frameENST00000445888ENST00000543296TP53chr17

7577499

-PXDNLchr8

52567320

-
In-frameENST00000455263ENST00000356297TP53chr17

7577499

-PXDNLchr8

52567320

-
intron-3CDSENST00000574684ENST00000356297TP53chr17

7577499

-PXDNLchr8

52567320

-
intron-3CDSENST00000574684ENST00000543296TP53chr17

7577499

-PXDNLchr8

52567320

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000413465TP53chr177577499-ENST00000356297PXDNLchr852567320-5322782050091669
ENST00000359597TP53chr177577499-ENST00000356297PXDNLchr852567320-5322782050091669
ENST00000269305TP53chr177577499-ENST00000543296PXDNLchr852567320-52619728547581557
ENST00000455263TP53chr177577499-ENST00000356297PXDNLchr852567320-54559152851421704
ENST00000420246TP53chr177577499-ENST00000356297PXDNLchr852567320-54559152851421704
ENST00000445888TP53chr177577499-ENST00000543296PXDNLchr852567320-52079183447041556

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000413465ENST00000356297TP53chr177577499-PXDNLchr852567320-0.0006309950.99936897
ENST00000359597ENST00000356297TP53chr177577499-PXDNLchr852567320-0.0006309950.99936897
ENST00000269305ENST00000543296TP53chr177577499-PXDNLchr852567320-0.0007331890.9992668
ENST00000455263ENST00000356297TP53chr177577499-PXDNLchr852567320-0.0007583380.9992417
ENST00000420246ENST00000356297TP53chr177577499-PXDNLchr852567320-0.0007583380.9992417
ENST00000445888ENST00000543296TP53chr177577499-PXDNLchr852567320-0.000710310.99928963

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Fusion Genomic Features for TP53-PXDNL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TP53-PXDNL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:7577499/chr8:52567320)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-71117_25260394.0MotifNote=TADI
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-71148_56260394.0MotifNote=TADII
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-71217_25260774.6666666666666MotifNote=TADI
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-71248_56260774.6666666666666MotifNote=TADII
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-71117_25260394.0MotifNote=TADI
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-71148_56260394.0MotifNote=TADII
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-71217_25260755.3333333333334MotifNote=TADI
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-71248_56260755.3333333333334MotifNote=TADII
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-7111_44260394.0RegionNote=Transcription activation (acidic)
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-7121_44260774.6666666666666RegionNote=Transcription activation (acidic)
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-7111_44260394.0RegionNote=Transcription activation (acidic)
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-7121_44260755.3333333333334RegionNote=Transcription activation (acidic)
TgenePXDNLchr17:7577499chr8:52567320ENST000003562970231393_1451541464.0DomainVWFC
TgenePXDNLchr17:7577499chr8:52567320ENST00000356297023180_233541464.0DomainNote=LRRCT
TgenePXDNLchr17:7577499chr8:52567320ENST00000356297023234_322541464.0DomainNote=Ig-like C2-type 1
TgenePXDNLchr17:7577499chr8:52567320ENST00000356297023330_414541464.0DomainNote=Ig-like C2-type 2
TgenePXDNLchr17:7577499chr8:52567320ENST00000356297023419_504541464.0DomainNote=Ig-like C2-type 3
TgenePXDNLchr17:7577499chr8:52567320ENST00000356297023507_596541464.0DomainNote=Ig-like C2-type 4
TgenePXDNLchr17:7577499chr8:52567320ENST000005432960211393_1451541388.6666666666667DomainVWFC
TgenePXDNLchr17:7577499chr8:52567320ENST00000543296021180_233541388.6666666666667DomainNote=LRRCT
TgenePXDNLchr17:7577499chr8:52567320ENST00000543296021234_322541388.6666666666667DomainNote=Ig-like C2-type 1
TgenePXDNLchr17:7577499chr8:52567320ENST00000543296021330_414541388.6666666666667DomainNote=Ig-like C2-type 2
TgenePXDNLchr17:7577499chr8:52567320ENST00000543296021419_504541388.6666666666667DomainNote=Ig-like C2-type 3
TgenePXDNLchr17:7577499chr8:52567320ENST00000543296021507_596541388.6666666666667DomainNote=Ig-like C2-type 4
TgenePXDNLchr17:7577499chr8:52567320ENST00000356297023123_144541464.0RepeatNote=LRR 4
TgenePXDNLchr17:7577499chr8:52567320ENST00000356297023147_168541464.0RepeatNote=LRR 5
TgenePXDNLchr17:7577499chr8:52567320ENST0000035629702375_96541464.0RepeatNote=LRR 2
TgenePXDNLchr17:7577499chr8:52567320ENST0000035629702399_120541464.0RepeatNote=LRR 3
TgenePXDNLchr17:7577499chr8:52567320ENST00000543296021123_144541388.6666666666667RepeatNote=LRR 4
TgenePXDNLchr17:7577499chr8:52567320ENST00000543296021147_168541388.6666666666667RepeatNote=LRR 5
TgenePXDNLchr17:7577499chr8:52567320ENST0000054329602175_96541388.6666666666667RepeatNote=LRR 2
TgenePXDNLchr17:7577499chr8:52567320ENST0000054329602199_120541388.6666666666667RepeatNote=LRR 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-711102_292260394.0DNA binding.
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-712102_292260774.6666666666666DNA binding.
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-711102_292260394.0DNA binding.
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-712102_292260755.3333333333334DNA binding.
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-711305_321260394.0MotifNote=Bipartite nuclear localization signal
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-711339_350260394.0MotifNote=Nuclear export signal
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-711370_372260394.0MotifNote=[KR]-[STA]-K motif
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-712305_321260774.6666666666666MotifNote=Bipartite nuclear localization signal
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-712339_350260774.6666666666666MotifNote=Nuclear export signal
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-712370_372260774.6666666666666MotifNote=[KR]-[STA]-K motif
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-711305_321260394.0MotifNote=Bipartite nuclear localization signal
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-711339_350260394.0MotifNote=Nuclear export signal
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-711370_372260394.0MotifNote=[KR]-[STA]-K motif
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-712305_321260755.3333333333334MotifNote=Bipartite nuclear localization signal
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-712339_350260755.3333333333334MotifNote=Nuclear export signal
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-712370_372260755.3333333333334MotifNote=[KR]-[STA]-K motif
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-711325_356260394.0RegionNote=Oligomerization
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-711368_387260394.0RegionNote=Basic (repression of DNA-binding)
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-712325_356260774.6666666666666RegionNote=Oligomerization
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-712368_387260774.6666666666666RegionNote=Basic (repression of DNA-binding)
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-711325_356260394.0RegionNote=Oligomerization
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-711368_387260394.0RegionNote=Basic (repression of DNA-binding)
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-712325_356260755.3333333333334RegionNote=Oligomerization
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-712368_387260755.3333333333334RegionNote=Basic (repression of DNA-binding)
TgenePXDNLchr17:7577499chr8:52567320ENST0000035629702324_50541464.0DomainNote=LRRNT
TgenePXDNLchr17:7577499chr8:52567320ENST0000054329602124_50541388.6666666666667DomainNote=LRRNT
TgenePXDNLchr17:7577499chr8:52567320ENST0000035629702351_72541464.0RepeatNote=LRR 1
TgenePXDNLchr17:7577499chr8:52567320ENST0000054329602151_72541388.6666666666667RepeatNote=LRR 1


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Fusion Gene Sequence for TP53-PXDNL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93236_93236_1_TP53-PXDNL_TP53_chr17_7577499_ENST00000269305_PXDNL_chr8_52567320_ENST00000543296_length(transcript)=5261nt_BP=972nt
GTTTTCCCCTCCCATGTGCTCAAGACTGGCGCTAAAAGTTTTGAGCTTCTCAAAAGTCTAGAGCCACCGTCCAGGGAGCAGGTAGCTGCT
GGGCTCCGGGGACACTTTGCGTTCGGGCTGGGAGCGTGCTTTCCACGACGGTGACACGCTTCCCTGGATTGGCAGCCAGACTGCCTTCCG
GGTCACTGCCATGGAGGAGCCGCAGTCAGATCCTAGCGTCGAGCCCCCTCTGAGTCAGGAAACATTTTCAGACCTATGGAAACTACTTCC
TGAAAACAACGTTCTGTCCCCCTTGCCGTCCCAAGCAATGGATGATTTGATGCTGTCCCCGGACGATATTGAACAATGGTTCACTGAAGA
CCCAGGTCCAGATGAAGCTCCCAGAATGCCAGAGGCTGCTCCCCCCGTGGCCCCTGCACCAGCAGCTCCTACACCGGCGGCCCCTGCACC
AGCCCCCTCCTGGCCCCTGTCATCTTCTGTCCCTTCCCAGAAAACCTACCAGGGCAGCTACGGTTTCCGTCTGGGCTTCTTGCATTCTGG
GACAGCCAAGTCTGTGACTTGCACGTACTCCCCTGCCCTCAACAAGATGTTTTGCCAACTGGCCAAGACCTGCCCTGTGCAGCTGTGGGT
TGATTCCACACCCCCGCCCGGCACCCGCGTCCGCGCCATGGCCATCTACAAGCAGTCACAGCACATGACGGAGGTTGTGAGGCGCTGCCC
CCACCATGAGCGCTGCTCAGATAGCGATGGTCTGGCCCCTCCTCAGCATCTTATCCGAGTGGAAGGAAATTTGCGTGTGGAGTATTTGGA
TGACAGAAACACTTTTCGACATAGTGTGGTGGTGCCCTATGAGCCGCCTGAGGTTGGCTCTGACTGTACCACCATCCACTACAACTACAT
GTGTAACAGTTCCTGCATGGGCGGCATGAACCGGAGGCCCATCCTCACCATCATCACACTGGAAGACTCCAGAGACTTGAGGTTTAACAG
AATAAGAGAAATTCCAGGGAGCGCCTTCAAGAAACTCAAGAATTTGAACACACTTCTGCTGAACAACAACCACATCAGAAAGATTTCCAG
AAATGCTTTTGAAGGACTTGAAAATTTGCTATATCTGTACCTGTATAAGAATGAAATCCATGCACTAGATAAGCAAACATTTAAAGGACT
CATATCTTTGGAACATCTGTATATTCATTTCAACCAACTAGAAATGCTACAGCCAGAGACCTTTGGAGACCTTCTGAGATTAGAGCGACT
ATTTTTGCATAACAACAAATTATCTAAAATTCCAGCTGGGAGCTTTTCTAATCTGGATTCATTAAAAAGATTGCGTCTGGATTCCAACGC
CCTGGTTTGTGACTGTGATCTGATGTGGCTGGGGGAGCTTTTACAAGGCTTTGCCCAACACGGCCACACCCAGGCTGCGGCTACCTGCGA
ATATCCCAGGAGACTCCATGGGCGTGCAGTTGCTTCAGTAACAGTAGAGGAATTCAATTGCCAGAGCCCCCGAATTACTTTTGAGCCGCA
GGATGTGGAGGTACCATCAGGAAATACCGTCTACTTCACCTGCCGGGCGGAAGGAAACCCCAAACCTGAGATTATTTGGATACACAACAA
CCACTCATTGGATTTGGAAGATGATACTCGACTTAATGTGTTTGATGATGGCACACTCATGATCCGAAACACCAGAGAGTCAGACCAAGG
TGTCTATCAGTGCATGGCCAGAAATTCCGCTGGGGAAGCCAAGACACAGAGTGCCATGCTCAGATACTCCAGTCTTCCAGCCAAACCAAG
CTTTGTAATCCAGCCTCAGGACACAGAGGTTTTAATTGGCACCAGCACAACTTTGGAATGTATGGCCACAGGCCACCCACACCCTCTTAT
CACTTGGACCAGGGACAATGGATTGGAGCTGGATGGATCCAGGCACGTGGCAACGTCCAGTGGACTTTACTTACAGAACATCACACAACG
GGATCATGGTCGATTTACCTGTCATGCCAACAATAGCCACGGCACTGTTCAAGCTGCAGCAAACATAATTGTACAAGCTCCTCCACAATT
TACAGTAACCCCCAAGGATCAAGTGGTGCTGGAAGAACATGCTGTAGAGTGGCTCTGTGAAGCTGACGGCAACCCACCTCCTGTTATTGT
CTGGACAAAAACAGGAGGGCAGCTCCCTGTGGAAGGCCAGCATACAGTTCTCTCCTCTGGCACTTTGAGAATTGACCGTGCAGCACAGCA
CGATCAAGGCCAATATGAATGTCAAGCAGTCAGTTCGTTGGGGGTGAAAAAGGTGTCTGTGCAGCTGACTGTAAAACCCAAAGCTCTTGC
AGTGTTTACTCAACTTCCTCAGGATACAAGTGTCGAGGTTGGAAAGAATATAAACATTTCATGTCATGCTCAAGGAGAACCACAGCCCAT
AATTACTTGGAATAAGGAAGGTGTGCAGATTACTGAGAGTGGTAAATTCCATGTGGATGATGAAGGCACGCTGACTATCTACGACGCAGG
GTTCCCTGACCAGGGAAGATATGAATGTGTGGCTCGGAATTCTTTTGGCCTTGCTGTGACCAACATGTTTCTTACAGTCACGGCTATACA
GGGTAGACAAGCTGGCGATGACTTTGTTGAATCTTCCATTCTTGATGCTGTACAGAGAGTTGACAGTGCAATTAACTCCACACGAAGACA
TTTGTTTTCACAAAAACCTCACACCTCCAGTGACCTGCTGGCTCAATTTCATTACCCGCGTGACCCACTGATTGTGGAAATGGCAAGAGC
AGGGGAGATTTTTGAGCACACGCTGCAGCTGATACGGGAACGTGTGAAGCAGGGGCTCACTGTGGACTTGGAAGGCAAAGAATTCCGGTA
CAATGACTTGGTGTCCCCGCGCTCCCTCAGCCTCATCGCCAATTTATCTGGATGCACAGCTCGCAGGCCTCTGCCAAACTGCTCCAACCG
GTGTTTCCATGCGAAGTACCGCGCCCACGACGGCACGTGCAACAACCTGCAGCAGCCCACGTGGGGCGCGGCGCTGACCGCCTTCGCGCG
CCTGCTGCAGCCAGCCTACCGGGACGGCATCCGCGCGCCCCGCGGGCTCGGCCTTCCTGTGGGCTCCCGCCAGCCCCTCCCGCCGCCCCG
GCTGGTCGCCACAGTGTGGGCGCGCGCGGCGGCCGTCACCCCCGACCACAGCTACACGCGCATGCTCATGCACTGGGGCTGGTTTCTAGA
GCACGACTTGGACCACACAGTGCCTGCGCTGAGCACAGCCCGCTTCTCGGATGGGCGGCCGTGCAGCTCCGTCTGCACCAACGACCCTCC
TTGTTTCCCCATGAACACCCGGCACGCCGACCCCCGGGGCACCCACGCGCCCTGCATGCTCTTCGCGCGCTCCAGCCCCGCGTGTGCCAG
CGGCCGTCCCTCTGCGACGGTGGATTCAGTCTATGCACGAGAGCAGATCAACCAGCAAACAGCCTACATCGATGGCTCCAACGTTTACGG
GAGCTCGGAGCGGGAATCCCAGGCTCTCAGAGACCCTTCGGTGCCTCGGGGTCTCCTGAAGACAGGCTTTCCTTGGCCTCCCTCCGGAAA
GCCCTTATTGCCCTTTTCTACAGGCCCACCCACCGAGTGCGCGCGACAGGAGCAGGAGAGCCCCTGTTTCCTGGCCGGGGACCACCGGGC
CAACGAGCATCTGGCTCTGGCCGCCATGCACACCCTGTGGTTCCGGGAACACAACAGGATGGCCACGGAGCTGTCCGCCCTGAACCCCCA
CTGGGAGGGAAACACGGTTTACCAGGAAGCCAGGAAGATCGTGGGCGCGGAGCTGCAGCACATCACCTACAGCCACTGGCTGCCTAAGGT
CCTGGGGGACCCTGGCACTAGGATGCTGAGGGGTTACCGAGGCTACAACCCCAACGTGAATGCAGGCATCATTAACTCTTTTGCTACTGC
AGCCTTTAGATTTGGCCACACATTAATCAATCCTATTCTTTACCGACTGAATGCCACCTTAGGTGAAATTTCCGAAGGCCACCTTCCGTT
CCATAAAGCGCTCTTTTCACCGTCCAGAATAATCAAGGAAGGTGGGATAGACCCGGTTCTCCGGGGGCTGTTTGGCGTGGCTGCTAAATG
GCGGGCACCCTCCTACCTTCTCAGTCCTGAGCTGACCCAGAGGCTCTTCTCCGCGGCTTATTCTGCGGCCGTGGATTCGGCTGCCACCAT
CATTCAAAGGGGTAGAGACCACGGGATCCCACCATATGTTGACTTCAGAGTTTTCTGTAATTTGACTTCAGTTAAGAACTTTGAGGATCT
TCAAAATGAAATTAAAGATTCAGAGATTAGACAAAAACTGAGAAAGTTGTACGGCTCTCCAGGTGACATTGACCTCTGGCCCGCCCTTAT
GGTTGAAGACCTGATTCCTGGTACAAGAGTGGGACCAACACTTATGTGCCTGTTTGTTACCCAGTTTCAGCGGCTAAGAGATGGAGATAG
GTTCTGGTATGAAAACCCTGGAGTATTTACCCCGGCACAACTCACTCAGCTGAAGCAGGCGTCCCTGAGCCGGGTGCTTTGTGACAATGG
TGACAGCATTCAGCAAGTGCAGGCTGATGTCTTTGTAAAGGCAGAATACCCACAGGATTACCTGAACTGCAGCGAGATCCCGAAGGTGGA
CCTGCGAGTGTGGCAAGACTGCTGTGCAGATAAACAAGCTGGAGGCACGCCTGAGGCAGGCAGGGTGTACAGATGTTAGAGGGGTTCCAA
GGAAGGCCGAGGAGCGCTGGATGAAAGAAGACTGCACTCACTGCATTTGTGAGAGTGGCCAGGTCACCTGTGTGGTGGAGATTTGTCCCC
CGGCTCCCTGTCCCAGTCCTGAATTGGTGAAAGGAACCTGCTGTCCAGTTTGCAGAGACCGAGGAATGCCAAGTGATTCCCCAGAGAAGC
GCTAATAAAAGTTTTGTGCTGTTGAGCCCCAAATGGGAAATTTCTCAGGAAGAGACATTTAGGACTTCAGAACTTTTAACTTGTAGTCAC
ATTGTTGATATGGAAACCACTGACTTAAGCAACTTAGTTCATCTAATCTTACATATACTTACGATCTTTTATTTTTTCATTTTCTAACAT
ACCTTGAAATAATTCAAAACTAAAAGCAATAAAGTGCATATGAAGTGTTTGATCATAAGAAATATTTCTTACTGTAAGCTGTCAGTTTTA

>93236_93236_1_TP53-PXDNL_TP53_chr17_7577499_ENST00000269305_PXDNL_chr8_52567320_ENST00000543296_length(amino acids)=1557AA_BP=295
MLGSGDTLRSGWERAFHDGDTLPWIGSQTAFRVTAMEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFT
EDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQL
WVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYN
YMCNSSCMGGMNRRPILTIITLEDSRDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFK
GLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAAT
CEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESD
QGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNIT
QRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAA
QHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYD
AGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMA
RAGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTWGAALTAF
ARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTND
PPCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPS
GKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLP
KVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAA
KWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPA
LMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPK

--------------------------------------------------------------
>93236_93236_2_TP53-PXDNL_TP53_chr17_7577499_ENST00000359597_PXDNL_chr8_52567320_ENST00000356297_length(transcript)=5322nt_BP=782nt
ATGGAGGAGCCGCAGTCAGATCCTAGCGTCGAGCCCCCTCTGAGTCAGGAAACATTTTCAGACCTATGGAAACTACTTCCTGAAAACAAC
GTTCTGTCCCCCTTGCCGTCCCAAGCAATGGATGATTTGATGCTGTCCCCGGACGATATTGAACAATGGTTCACTGAAGACCCAGGTCCA
GATGAAGCTCCCAGAATGCCAGAGGCTGCTCCCCCCGTGGCCCCTGCACCAGCAGCTCCTACACCGGCGGCCCCTGCACCAGCCCCCTCC
TGGCCCCTGTCATCTTCTGTCCCTTCCCAGAAAACCTACCAGGGCAGCTACGGTTTCCGTCTGGGCTTCTTGCATTCTGGGACAGCCAAG
TCTGTGACTTGCACGTACTCCCCTGCCCTCAACAAGATGTTTTGCCAACTGGCCAAGACCTGCCCTGTGCAGCTGTGGGTTGATTCCACA
CCCCCGCCCGGCACCCGCGTCCGCGCCATGGCCATCTACAAGCAGTCACAGCACATGACGGAGGTTGTGAGGCGCTGCCCCCACCATGAG
CGCTGCTCAGATAGCGATGGTCTGGCCCCTCCTCAGCATCTTATCCGAGTGGAAGGAAATTTGCGTGTGGAGTATTTGGATGACAGAAAC
ACTTTTCGACATAGTGTGGTGGTGCCCTATGAGCCGCCTGAGGTTGGCTCTGACTGTACCACCATCCACTACAACTACATGTGTAACAGT
TCCTGCATGGGCGGCATGAACCGGAGGCCCATCCTCACCATCATCACACTGGAAGACTCCAGAGACTTGAGGTTTAACAGAATAAGAGAA
ATTCCAGGGAGCGCCTTCAAGAAACTCAAGAATTTGAACACACTTCTGCTGAACAACAACCACATCAGAAAGATTTCCAGAAATGCTTTT
GAAGGACTTGAAAATTTGCTATATCTGTACCTGTATAAGAATGAAATCCATGCACTAGATAAGCAAACATTTAAAGGACTCATATCTTTG
GAACATCTGTATATTCATTTCAACCAACTAGAAATGCTACAGCCAGAGACCTTTGGAGACCTTCTGAGATTAGAGCGACTATTTTTGCAT
AACAACAAATTATCTAAAATTCCAGCTGGGAGCTTTTCTAATCTGGATTCATTAAAAAGATTGCGTCTGGATTCCAACGCCCTGGTTTGT
GACTGTGATCTGATGTGGCTGGGGGAGCTTTTACAAGGCTTTGCCCAACACGGCCACACCCAGGCTGCGGCTACCTGCGAATATCCCAGG
AGACTCCATGGGCGTGCAGTTGCTTCAGTAACAGTAGAGGAATTCAATTGCCAGAGCCCCCGAATTACTTTTGAGCCGCAGGATGTGGAG
GTACCATCAGGAAATACCGTCTACTTCACCTGCCGGGCGGAAGGAAACCCCAAACCTGAGATTATTTGGATACACAACAACCACTCATTG
GATTTGGAAGATGATACTCGACTTAATGTGTTTGATGATGGCACACTCATGATCCGAAACACCAGAGAGTCAGACCAAGGTGTCTATCAG
TGCATGGCCAGAAATTCCGCTGGGGAAGCCAAGACACAGAGTGCCATGCTCAGATACTCCAGTCTTCCAGCCAAACCAAGCTTTGTAATC
CAGCCTCAGGACACAGAGGTTTTAATTGGCACCAGCACAACTTTGGAATGTATGGCCACAGGCCACCCACACCCTCTTATCACTTGGACC
AGGGACAATGGATTGGAGCTGGATGGATCCAGGCACGTGGCAACGTCCAGTGGACTTTACTTACAGAACATCACACAACGGGATCATGGT
CGATTTACCTGTCATGCCAACAATAGCCACGGCACTGTTCAAGCTGCAGCAAACATAATTGTACAAGCTCCTCCACAATTTACAGTAACC
CCCAAGGATCAAGTGGTGCTGGAAGAACATGCTGTAGAGTGGCTCTGTGAAGCTGACGGCAACCCACCTCCTGTTATTGTCTGGACAAAA
ACAGGAGGGCAGCTCCCTGTGGAAGGCCAGCATACAGTTCTCTCCTCTGGCACTTTGAGAATTGACCGTGCAGCACAGCACGATCAAGGC
CAATATGAATGTCAAGCAGTCAGTTCGTTGGGGGTGAAAAAGGTGTCTGTGCAGCTGACTGTAAAACCCAAAGCTCTTGCAGTGTTTACT
CAACTTCCTCAGGATACAAGTGTCGAGGTTGGAAAGAATATAAACATTTCATGTCATGCTCAAGGAGAACCACAGCCCATAATTACTTGG
AATAAGGAAGGTGTGCAGATTACTGAGAGTGGTAAATTCCATGTGGATGATGAAGGCACGCTGACTATCTACGACGCAGGGTTCCCTGAC
CAGGGAAGATATGAATGTGTGGCTCGGAATTCTTTTGGCCTTGCTGTGACCAACATGTTTCTTACAGTCACGGCTATACAGGGTAGACAA
GCTGGCGATGACTTTGTTGAATCTTCCATTCTTGATGCTGTACAGAGAGTTGACAGTGCAATTAACTCCACACGAAGACATTTGTTTTCA
CAAAAACCTCACACCTCCAGTGACCTGCTGGCTCAATTTCATTACCCGCGTGACCCACTGATTGTGGAAATGGCAAGAGCAGGGGAGATT
TTTGAGCACACGCTGCAGCTGATACGGGAACGTGTGAAGCAGGGGCTCACTGTGGACTTGGAAGGCAAAGAATTCCGGTACAATGACTTG
GTGTCCCCGCGCTCCCTCAGCCTCATCGCCAATTTATCTGGATGCACAGCTCGCAGGCCTCTGCCAAACTGCTCCAACCGGTGTTTCCAT
GCGAAGTACCGCGCCCACGACGGCACGTGCAACAACCTGCAGCAGCCCACGTGGGGCGCGGCGCTGACCGCCTTCGCGCGCCTGCTGCAG
CCAGCCTACCGGGACGGCATCCGCGCGCCCCGCGGGCTCGGCCTTCCTGTGGGCTCCCGCCAGCCCCTCCCGCCGCCCCGGCTGGTCGCC
ACAGTGTGGGCGCGCGCGGCGGCCGTCACCCCCGACCACAGCTACACGCGCATGCTCATGCACTGGGGCTGGTTTCTAGAGCACGACTTG
GACCACACAGTGCCTGCGCTGAGCACAGCCCGCTTCTCGGATGGGCGGCCGTGCAGCTCCGTCTGCACCAACGACCCTCCTTGTTTCCCC
ATGAACACCCGGCACGCCGACCCCCGGGGCACCCACGCGCCCTGCATGCTCTTCGCGCGCTCCAGCCCCGCGTGTGCCAGCGGCCGTCCC
TCTGCGACGGTGGATTCAGTCTATGCACGAGAGCAGATCAACCAGCAAACAGCCTACATCGATGGCTCCAACGTTTACGGGAGCTCGGAG
CGGGAATCCCAGGCTCTCAGAGACCCTTCGGTGCCTCGGGGTCTCCTGAAGACAGGCTTTCCTTGGCCTCCCTCCGGAAAGCCCTTATTG
CCCTTTTCTACAGGCCCACCCACCGAGTGCGCGCGACAGGAGCAGGAGAGCCCCTGTTTCCTGGCCGGGGACCACCGGGCCAACGAGCAT
CTGGCTCTGGCCGCCATGCACACCCTGTGGTTCCGGGAACACAACAGGATGGCCACGGAGCTGTCCGCCCTGAACCCCCACTGGGAGGGA
AACACGGTTTACCAGGAAGCCAGGAAGATCGTGGGCGCGGAGCTGCAGCACATCACCTACAGCCACTGGCTGCCTAAGGTCCTGGGGGAC
CCTGGCACTAGGATGCTGAGGGGTTACCGAGGCTACAACCCCAACGTGAATGCAGGCATCATTAACTCTTTTGCTACTGCAGCCTTTAGA
TTTGGCCACACATTAATCAATCCTATTCTTTACCGACTGAATGCCACCTTAGGTGAAATTTCCGAAGGCCACCTTCCGTTCCATAAAGCG
CTCTTTTCACCGTCCAGAATAATCAAGGAAGGTGGGATAGACCCGGTTCTCCGGGGGCTGTTTGGCGTGGCTGCTAAATGGCGGGCACCC
TCCTACCTTCTCAGTCCTGAGCTGACCCAGAGGCTCTTCTCCGCGGCTTATTCTGCGGCCGTGGATTCGGCTGCCACCATCATTCAAAGG
GGTAGAGACCACGGGATCCCACCATATGTTGACTTCAGAGTTTTCTGTAATTTGACTTCAGTTAAGAACTTTGAGGATCTTCAAAATGAA
ATTAAAGATTCAGAGATTAGACAAAAACTGAGAAAGTTGTACGGCTCTCCAGGTGACATTGACCTCTGGCCCGCCCTTATGGTTGAAGAC
CTGATTCCTGGTACAAGAGTGGGACCAACACTTATGTGCCTGTTTGTTACCCAGTTTCAGCGGCTAAGAGATGGAGATAGGTTCTGGTAT
GAAAACCCTGGAGTATTTACCCCGGCACAACTCACTCAGCTGAAGCAGGCGTCCCTGAGCCGGGTGCTTTGTGACAATGGTGACAGCATT
CAGCAAGTGCAGGCTGATGTCTTTGTAAAGGCAGAATACCCACAGGATTACCTGAACTGCAGCGAGATCCCGAAGGTGGACCTGCGAGTG
TGGCAAGACTGCTGTGCAGACTGTAGGAGTAGAGGACAGTTCAGAGCAGTGACGCAAGAGTCTCAAAAGAAACGCTCAGCTCAATACAGC
TATCCTGTTGATAAGGATATGGAGTTAAGTCATCTAAGAAGTAGGCAACAAGATAAAATATATGTGGGTGAAGATGCTAGAAATGTGACA
GTTCTGGCAAAAACAAAGTTCTCCCAAGATTTCAGCACGTTTGCAGCGGAAATTCAGGAAACCATCACAGCACTCAGAGAGCAGATAAAC
AAGCTGGAGGCACGCCTGAGGCAGGCAGGGTGTACAGATGTTAGAGGGGTTCCAAGGAAGGCCGAGGAGCGCTGGATGAAAGAAGACTGC
ACTCACTGCATTTGTGAGAGTGGCCAGGTCACCTGTGTGGTGGAGATTTGTCCCCCGGCTCCCTGTCCCAGTCCTGAATTGGTGAAAGGA
ACCTGCTGTCCAGTTTGCAGAGACCGAGGAATGCCAAGTGATTCCCCAGAGAAGCGCTAATAAAAGTTTTGTGCTGTTGAGCCCCAAATG
GGAAATTTCTCAGGAAGAGACATTTAGGACTTCAGAACTTTTAACTTGTAGTCACATTGTTGATATGGAAACCACTGACTTAAGCAACTT
AGTTCATCTAATCTTACATATACTTACGATCTTTTATTTTTTCATTTTCTAACATACCTTGAAATAATTCAAAACTAAAAGCAATAAAGT
GCATATGAAGTGTTTGATCATAAGAAATATTTCTTACTGTAAGCTGTCAGTTTTATATGCCACACCTGGAAATAAAAAGAATATCATGGA

>93236_93236_2_TP53-PXDNL_TP53_chr17_7577499_ENST00000359597_PXDNL_chr8_52567320_ENST00000356297_length(amino acids)=1669AA_BP=260
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPS
WPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSRDLRFNRIRE
IPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLH
NNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVE
VPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVI
QPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVT
PKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFT
QLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQ
AGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDL
VSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVA
TVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMNTRHADPRGTHAPCMLFARSSPACASGRP
SATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEH
LALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFR
FGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQR
GRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWY
ENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRSAQYS
YPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITALREQINKLEARLRQAGCTDVRGVPRKAEERWMKEDC

--------------------------------------------------------------
>93236_93236_3_TP53-PXDNL_TP53_chr17_7577499_ENST00000413465_PXDNL_chr8_52567320_ENST00000356297_length(transcript)=5322nt_BP=782nt
ATGGAGGAGCCGCAGTCAGATCCTAGCGTCGAGCCCCCTCTGAGTCAGGAAACATTTTCAGACCTATGGAAACTACTTCCTGAAAACAAC
GTTCTGTCCCCCTTGCCGTCCCAAGCAATGGATGATTTGATGCTGTCCCCGGACGATATTGAACAATGGTTCACTGAAGACCCAGGTCCA
GATGAAGCTCCCAGAATGCCAGAGGCTGCTCCCCCCGTGGCCCCTGCACCAGCAGCTCCTACACCGGCGGCCCCTGCACCAGCCCCCTCC
TGGCCCCTGTCATCTTCTGTCCCTTCCCAGAAAACCTACCAGGGCAGCTACGGTTTCCGTCTGGGCTTCTTGCATTCTGGGACAGCCAAG
TCTGTGACTTGCACGTACTCCCCTGCCCTCAACAAGATGTTTTGCCAACTGGCCAAGACCTGCCCTGTGCAGCTGTGGGTTGATTCCACA
CCCCCGCCCGGCACCCGCGTCCGCGCCATGGCCATCTACAAGCAGTCACAGCACATGACGGAGGTTGTGAGGCGCTGCCCCCACCATGAG
CGCTGCTCAGATAGCGATGGTCTGGCCCCTCCTCAGCATCTTATCCGAGTGGAAGGAAATTTGCGTGTGGAGTATTTGGATGACAGAAAC
ACTTTTCGACATAGTGTGGTGGTGCCCTATGAGCCGCCTGAGGTTGGCTCTGACTGTACCACCATCCACTACAACTACATGTGTAACAGT
TCCTGCATGGGCGGCATGAACCGGAGGCCCATCCTCACCATCATCACACTGGAAGACTCCAGAGACTTGAGGTTTAACAGAATAAGAGAA
ATTCCAGGGAGCGCCTTCAAGAAACTCAAGAATTTGAACACACTTCTGCTGAACAACAACCACATCAGAAAGATTTCCAGAAATGCTTTT
GAAGGACTTGAAAATTTGCTATATCTGTACCTGTATAAGAATGAAATCCATGCACTAGATAAGCAAACATTTAAAGGACTCATATCTTTG
GAACATCTGTATATTCATTTCAACCAACTAGAAATGCTACAGCCAGAGACCTTTGGAGACCTTCTGAGATTAGAGCGACTATTTTTGCAT
AACAACAAATTATCTAAAATTCCAGCTGGGAGCTTTTCTAATCTGGATTCATTAAAAAGATTGCGTCTGGATTCCAACGCCCTGGTTTGT
GACTGTGATCTGATGTGGCTGGGGGAGCTTTTACAAGGCTTTGCCCAACACGGCCACACCCAGGCTGCGGCTACCTGCGAATATCCCAGG
AGACTCCATGGGCGTGCAGTTGCTTCAGTAACAGTAGAGGAATTCAATTGCCAGAGCCCCCGAATTACTTTTGAGCCGCAGGATGTGGAG
GTACCATCAGGAAATACCGTCTACTTCACCTGCCGGGCGGAAGGAAACCCCAAACCTGAGATTATTTGGATACACAACAACCACTCATTG
GATTTGGAAGATGATACTCGACTTAATGTGTTTGATGATGGCACACTCATGATCCGAAACACCAGAGAGTCAGACCAAGGTGTCTATCAG
TGCATGGCCAGAAATTCCGCTGGGGAAGCCAAGACACAGAGTGCCATGCTCAGATACTCCAGTCTTCCAGCCAAACCAAGCTTTGTAATC
CAGCCTCAGGACACAGAGGTTTTAATTGGCACCAGCACAACTTTGGAATGTATGGCCACAGGCCACCCACACCCTCTTATCACTTGGACC
AGGGACAATGGATTGGAGCTGGATGGATCCAGGCACGTGGCAACGTCCAGTGGACTTTACTTACAGAACATCACACAACGGGATCATGGT
CGATTTACCTGTCATGCCAACAATAGCCACGGCACTGTTCAAGCTGCAGCAAACATAATTGTACAAGCTCCTCCACAATTTACAGTAACC
CCCAAGGATCAAGTGGTGCTGGAAGAACATGCTGTAGAGTGGCTCTGTGAAGCTGACGGCAACCCACCTCCTGTTATTGTCTGGACAAAA
ACAGGAGGGCAGCTCCCTGTGGAAGGCCAGCATACAGTTCTCTCCTCTGGCACTTTGAGAATTGACCGTGCAGCACAGCACGATCAAGGC
CAATATGAATGTCAAGCAGTCAGTTCGTTGGGGGTGAAAAAGGTGTCTGTGCAGCTGACTGTAAAACCCAAAGCTCTTGCAGTGTTTACT
CAACTTCCTCAGGATACAAGTGTCGAGGTTGGAAAGAATATAAACATTTCATGTCATGCTCAAGGAGAACCACAGCCCATAATTACTTGG
AATAAGGAAGGTGTGCAGATTACTGAGAGTGGTAAATTCCATGTGGATGATGAAGGCACGCTGACTATCTACGACGCAGGGTTCCCTGAC
CAGGGAAGATATGAATGTGTGGCTCGGAATTCTTTTGGCCTTGCTGTGACCAACATGTTTCTTACAGTCACGGCTATACAGGGTAGACAA
GCTGGCGATGACTTTGTTGAATCTTCCATTCTTGATGCTGTACAGAGAGTTGACAGTGCAATTAACTCCACACGAAGACATTTGTTTTCA
CAAAAACCTCACACCTCCAGTGACCTGCTGGCTCAATTTCATTACCCGCGTGACCCACTGATTGTGGAAATGGCAAGAGCAGGGGAGATT
TTTGAGCACACGCTGCAGCTGATACGGGAACGTGTGAAGCAGGGGCTCACTGTGGACTTGGAAGGCAAAGAATTCCGGTACAATGACTTG
GTGTCCCCGCGCTCCCTCAGCCTCATCGCCAATTTATCTGGATGCACAGCTCGCAGGCCTCTGCCAAACTGCTCCAACCGGTGTTTCCAT
GCGAAGTACCGCGCCCACGACGGCACGTGCAACAACCTGCAGCAGCCCACGTGGGGCGCGGCGCTGACCGCCTTCGCGCGCCTGCTGCAG
CCAGCCTACCGGGACGGCATCCGCGCGCCCCGCGGGCTCGGCCTTCCTGTGGGCTCCCGCCAGCCCCTCCCGCCGCCCCGGCTGGTCGCC
ACAGTGTGGGCGCGCGCGGCGGCCGTCACCCCCGACCACAGCTACACGCGCATGCTCATGCACTGGGGCTGGTTTCTAGAGCACGACTTG
GACCACACAGTGCCTGCGCTGAGCACAGCCCGCTTCTCGGATGGGCGGCCGTGCAGCTCCGTCTGCACCAACGACCCTCCTTGTTTCCCC
ATGAACACCCGGCACGCCGACCCCCGGGGCACCCACGCGCCCTGCATGCTCTTCGCGCGCTCCAGCCCCGCGTGTGCCAGCGGCCGTCCC
TCTGCGACGGTGGATTCAGTCTATGCACGAGAGCAGATCAACCAGCAAACAGCCTACATCGATGGCTCCAACGTTTACGGGAGCTCGGAG
CGGGAATCCCAGGCTCTCAGAGACCCTTCGGTGCCTCGGGGTCTCCTGAAGACAGGCTTTCCTTGGCCTCCCTCCGGAAAGCCCTTATTG
CCCTTTTCTACAGGCCCACCCACCGAGTGCGCGCGACAGGAGCAGGAGAGCCCCTGTTTCCTGGCCGGGGACCACCGGGCCAACGAGCAT
CTGGCTCTGGCCGCCATGCACACCCTGTGGTTCCGGGAACACAACAGGATGGCCACGGAGCTGTCCGCCCTGAACCCCCACTGGGAGGGA
AACACGGTTTACCAGGAAGCCAGGAAGATCGTGGGCGCGGAGCTGCAGCACATCACCTACAGCCACTGGCTGCCTAAGGTCCTGGGGGAC
CCTGGCACTAGGATGCTGAGGGGTTACCGAGGCTACAACCCCAACGTGAATGCAGGCATCATTAACTCTTTTGCTACTGCAGCCTTTAGA
TTTGGCCACACATTAATCAATCCTATTCTTTACCGACTGAATGCCACCTTAGGTGAAATTTCCGAAGGCCACCTTCCGTTCCATAAAGCG
CTCTTTTCACCGTCCAGAATAATCAAGGAAGGTGGGATAGACCCGGTTCTCCGGGGGCTGTTTGGCGTGGCTGCTAAATGGCGGGCACCC
TCCTACCTTCTCAGTCCTGAGCTGACCCAGAGGCTCTTCTCCGCGGCTTATTCTGCGGCCGTGGATTCGGCTGCCACCATCATTCAAAGG
GGTAGAGACCACGGGATCCCACCATATGTTGACTTCAGAGTTTTCTGTAATTTGACTTCAGTTAAGAACTTTGAGGATCTTCAAAATGAA
ATTAAAGATTCAGAGATTAGACAAAAACTGAGAAAGTTGTACGGCTCTCCAGGTGACATTGACCTCTGGCCCGCCCTTATGGTTGAAGAC
CTGATTCCTGGTACAAGAGTGGGACCAACACTTATGTGCCTGTTTGTTACCCAGTTTCAGCGGCTAAGAGATGGAGATAGGTTCTGGTAT
GAAAACCCTGGAGTATTTACCCCGGCACAACTCACTCAGCTGAAGCAGGCGTCCCTGAGCCGGGTGCTTTGTGACAATGGTGACAGCATT
CAGCAAGTGCAGGCTGATGTCTTTGTAAAGGCAGAATACCCACAGGATTACCTGAACTGCAGCGAGATCCCGAAGGTGGACCTGCGAGTG
TGGCAAGACTGCTGTGCAGACTGTAGGAGTAGAGGACAGTTCAGAGCAGTGACGCAAGAGTCTCAAAAGAAACGCTCAGCTCAATACAGC
TATCCTGTTGATAAGGATATGGAGTTAAGTCATCTAAGAAGTAGGCAACAAGATAAAATATATGTGGGTGAAGATGCTAGAAATGTGACA
GTTCTGGCAAAAACAAAGTTCTCCCAAGATTTCAGCACGTTTGCAGCGGAAATTCAGGAAACCATCACAGCACTCAGAGAGCAGATAAAC
AAGCTGGAGGCACGCCTGAGGCAGGCAGGGTGTACAGATGTTAGAGGGGTTCCAAGGAAGGCCGAGGAGCGCTGGATGAAAGAAGACTGC
ACTCACTGCATTTGTGAGAGTGGCCAGGTCACCTGTGTGGTGGAGATTTGTCCCCCGGCTCCCTGTCCCAGTCCTGAATTGGTGAAAGGA
ACCTGCTGTCCAGTTTGCAGAGACCGAGGAATGCCAAGTGATTCCCCAGAGAAGCGCTAATAAAAGTTTTGTGCTGTTGAGCCCCAAATG
GGAAATTTCTCAGGAAGAGACATTTAGGACTTCAGAACTTTTAACTTGTAGTCACATTGTTGATATGGAAACCACTGACTTAAGCAACTT
AGTTCATCTAATCTTACATATACTTACGATCTTTTATTTTTTCATTTTCTAACATACCTTGAAATAATTCAAAACTAAAAGCAATAAAGT
GCATATGAAGTGTTTGATCATAAGAAATATTTCTTACTGTAAGCTGTCAGTTTTATATGCCACACCTGGAAATAAAAAGAATATCATGGA

>93236_93236_3_TP53-PXDNL_TP53_chr17_7577499_ENST00000413465_PXDNL_chr8_52567320_ENST00000356297_length(amino acids)=1669AA_BP=260
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPS
WPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSRDLRFNRIRE
IPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLH
NNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVE
VPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVI
QPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVT
PKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFT
QLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQ
AGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDL
VSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVA
TVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMNTRHADPRGTHAPCMLFARSSPACASGRP
SATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEH
LALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFR
FGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQR
GRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWY
ENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRSAQYS
YPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITALREQINKLEARLRQAGCTDVRGVPRKAEERWMKEDC

--------------------------------------------------------------
>93236_93236_4_TP53-PXDNL_TP53_chr17_7577499_ENST00000420246_PXDNL_chr8_52567320_ENST00000356297_length(transcript)=5455nt_BP=915nt
CTAGAGCCACCGTCCAGGGAGCAGGTAGCTGCTGGGCTCCGGGGACACTTTGCGTTCGGGCTGGGAGCGTGCTTTCCACGACGGTGACAC
GCTTCCCTGGATTGGCAGCCAGACTGCCTTCCGGGTCACTGCCATGGAGGAGCCGCAGTCAGATCCTAGCGTCGAGCCCCCTCTGAGTCA
GGAAACATTTTCAGACCTATGGAAACTACTTCCTGAAAACAACGTTCTGTCCCCCTTGCCGTCCCAAGCAATGGATGATTTGATGCTGTC
CCCGGACGATATTGAACAATGGTTCACTGAAGACCCAGGTCCAGATGAAGCTCCCAGAATGCCAGAGGCTGCTCCCCCCGTGGCCCCTGC
ACCAGCAGCTCCTACACCGGCGGCCCCTGCACCAGCCCCCTCCTGGCCCCTGTCATCTTCTGTCCCTTCCCAGAAAACCTACCAGGGCAG
CTACGGTTTCCGTCTGGGCTTCTTGCATTCTGGGACAGCCAAGTCTGTGACTTGCACGTACTCCCCTGCCCTCAACAAGATGTTTTGCCA
ACTGGCCAAGACCTGCCCTGTGCAGCTGTGGGTTGATTCCACACCCCCGCCCGGCACCCGCGTCCGCGCCATGGCCATCTACAAGCAGTC
ACAGCACATGACGGAGGTTGTGAGGCGCTGCCCCCACCATGAGCGCTGCTCAGATAGCGATGGTCTGGCCCCTCCTCAGCATCTTATCCG
AGTGGAAGGAAATTTGCGTGTGGAGTATTTGGATGACAGAAACACTTTTCGACATAGTGTGGTGGTGCCCTATGAGCCGCCTGAGGTTGG
CTCTGACTGTACCACCATCCACTACAACTACATGTGTAACAGTTCCTGCATGGGCGGCATGAACCGGAGGCCCATCCTCACCATCATCAC
ACTGGAAGACTCCAGAGACTTGAGGTTTAACAGAATAAGAGAAATTCCAGGGAGCGCCTTCAAGAAACTCAAGAATTTGAACACACTTCT
GCTGAACAACAACCACATCAGAAAGATTTCCAGAAATGCTTTTGAAGGACTTGAAAATTTGCTATATCTGTACCTGTATAAGAATGAAAT
CCATGCACTAGATAAGCAAACATTTAAAGGACTCATATCTTTGGAACATCTGTATATTCATTTCAACCAACTAGAAATGCTACAGCCAGA
GACCTTTGGAGACCTTCTGAGATTAGAGCGACTATTTTTGCATAACAACAAATTATCTAAAATTCCAGCTGGGAGCTTTTCTAATCTGGA
TTCATTAAAAAGATTGCGTCTGGATTCCAACGCCCTGGTTTGTGACTGTGATCTGATGTGGCTGGGGGAGCTTTTACAAGGCTTTGCCCA
ACACGGCCACACCCAGGCTGCGGCTACCTGCGAATATCCCAGGAGACTCCATGGGCGTGCAGTTGCTTCAGTAACAGTAGAGGAATTCAA
TTGCCAGAGCCCCCGAATTACTTTTGAGCCGCAGGATGTGGAGGTACCATCAGGAAATACCGTCTACTTCACCTGCCGGGCGGAAGGAAA
CCCCAAACCTGAGATTATTTGGATACACAACAACCACTCATTGGATTTGGAAGATGATACTCGACTTAATGTGTTTGATGATGGCACACT
CATGATCCGAAACACCAGAGAGTCAGACCAAGGTGTCTATCAGTGCATGGCCAGAAATTCCGCTGGGGAAGCCAAGACACAGAGTGCCAT
GCTCAGATACTCCAGTCTTCCAGCCAAACCAAGCTTTGTAATCCAGCCTCAGGACACAGAGGTTTTAATTGGCACCAGCACAACTTTGGA
ATGTATGGCCACAGGCCACCCACACCCTCTTATCACTTGGACCAGGGACAATGGATTGGAGCTGGATGGATCCAGGCACGTGGCAACGTC
CAGTGGACTTTACTTACAGAACATCACACAACGGGATCATGGTCGATTTACCTGTCATGCCAACAATAGCCACGGCACTGTTCAAGCTGC
AGCAAACATAATTGTACAAGCTCCTCCACAATTTACAGTAACCCCCAAGGATCAAGTGGTGCTGGAAGAACATGCTGTAGAGTGGCTCTG
TGAAGCTGACGGCAACCCACCTCCTGTTATTGTCTGGACAAAAACAGGAGGGCAGCTCCCTGTGGAAGGCCAGCATACAGTTCTCTCCTC
TGGCACTTTGAGAATTGACCGTGCAGCACAGCACGATCAAGGCCAATATGAATGTCAAGCAGTCAGTTCGTTGGGGGTGAAAAAGGTGTC
TGTGCAGCTGACTGTAAAACCCAAAGCTCTTGCAGTGTTTACTCAACTTCCTCAGGATACAAGTGTCGAGGTTGGAAAGAATATAAACAT
TTCATGTCATGCTCAAGGAGAACCACAGCCCATAATTACTTGGAATAAGGAAGGTGTGCAGATTACTGAGAGTGGTAAATTCCATGTGGA
TGATGAAGGCACGCTGACTATCTACGACGCAGGGTTCCCTGACCAGGGAAGATATGAATGTGTGGCTCGGAATTCTTTTGGCCTTGCTGT
GACCAACATGTTTCTTACAGTCACGGCTATACAGGGTAGACAAGCTGGCGATGACTTTGTTGAATCTTCCATTCTTGATGCTGTACAGAG
AGTTGACAGTGCAATTAACTCCACACGAAGACATTTGTTTTCACAAAAACCTCACACCTCCAGTGACCTGCTGGCTCAATTTCATTACCC
GCGTGACCCACTGATTGTGGAAATGGCAAGAGCAGGGGAGATTTTTGAGCACACGCTGCAGCTGATACGGGAACGTGTGAAGCAGGGGCT
CACTGTGGACTTGGAAGGCAAAGAATTCCGGTACAATGACTTGGTGTCCCCGCGCTCCCTCAGCCTCATCGCCAATTTATCTGGATGCAC
AGCTCGCAGGCCTCTGCCAAACTGCTCCAACCGGTGTTTCCATGCGAAGTACCGCGCCCACGACGGCACGTGCAACAACCTGCAGCAGCC
CACGTGGGGCGCGGCGCTGACCGCCTTCGCGCGCCTGCTGCAGCCAGCCTACCGGGACGGCATCCGCGCGCCCCGCGGGCTCGGCCTTCC
TGTGGGCTCCCGCCAGCCCCTCCCGCCGCCCCGGCTGGTCGCCACAGTGTGGGCGCGCGCGGCGGCCGTCACCCCCGACCACAGCTACAC
GCGCATGCTCATGCACTGGGGCTGGTTTCTAGAGCACGACTTGGACCACACAGTGCCTGCGCTGAGCACAGCCCGCTTCTCGGATGGGCG
GCCGTGCAGCTCCGTCTGCACCAACGACCCTCCTTGTTTCCCCATGAACACCCGGCACGCCGACCCCCGGGGCACCCACGCGCCCTGCAT
GCTCTTCGCGCGCTCCAGCCCCGCGTGTGCCAGCGGCCGTCCCTCTGCGACGGTGGATTCAGTCTATGCACGAGAGCAGATCAACCAGCA
AACAGCCTACATCGATGGCTCCAACGTTTACGGGAGCTCGGAGCGGGAATCCCAGGCTCTCAGAGACCCTTCGGTGCCTCGGGGTCTCCT
GAAGACAGGCTTTCCTTGGCCTCCCTCCGGAAAGCCCTTATTGCCCTTTTCTACAGGCCCACCCACCGAGTGCGCGCGACAGGAGCAGGA
GAGCCCCTGTTTCCTGGCCGGGGACCACCGGGCCAACGAGCATCTGGCTCTGGCCGCCATGCACACCCTGTGGTTCCGGGAACACAACAG
GATGGCCACGGAGCTGTCCGCCCTGAACCCCCACTGGGAGGGAAACACGGTTTACCAGGAAGCCAGGAAGATCGTGGGCGCGGAGCTGCA
GCACATCACCTACAGCCACTGGCTGCCTAAGGTCCTGGGGGACCCTGGCACTAGGATGCTGAGGGGTTACCGAGGCTACAACCCCAACGT
GAATGCAGGCATCATTAACTCTTTTGCTACTGCAGCCTTTAGATTTGGCCACACATTAATCAATCCTATTCTTTACCGACTGAATGCCAC
CTTAGGTGAAATTTCCGAAGGCCACCTTCCGTTCCATAAAGCGCTCTTTTCACCGTCCAGAATAATCAAGGAAGGTGGGATAGACCCGGT
TCTCCGGGGGCTGTTTGGCGTGGCTGCTAAATGGCGGGCACCCTCCTACCTTCTCAGTCCTGAGCTGACCCAGAGGCTCTTCTCCGCGGC
TTATTCTGCGGCCGTGGATTCGGCTGCCACCATCATTCAAAGGGGTAGAGACCACGGGATCCCACCATATGTTGACTTCAGAGTTTTCTG
TAATTTGACTTCAGTTAAGAACTTTGAGGATCTTCAAAATGAAATTAAAGATTCAGAGATTAGACAAAAACTGAGAAAGTTGTACGGCTC
TCCAGGTGACATTGACCTCTGGCCCGCCCTTATGGTTGAAGACCTGATTCCTGGTACAAGAGTGGGACCAACACTTATGTGCCTGTTTGT
TACCCAGTTTCAGCGGCTAAGAGATGGAGATAGGTTCTGGTATGAAAACCCTGGAGTATTTACCCCGGCACAACTCACTCAGCTGAAGCA
GGCGTCCCTGAGCCGGGTGCTTTGTGACAATGGTGACAGCATTCAGCAAGTGCAGGCTGATGTCTTTGTAAAGGCAGAATACCCACAGGA
TTACCTGAACTGCAGCGAGATCCCGAAGGTGGACCTGCGAGTGTGGCAAGACTGCTGTGCAGACTGTAGGAGTAGAGGACAGTTCAGAGC
AGTGACGCAAGAGTCTCAAAAGAAACGCTCAGCTCAATACAGCTATCCTGTTGATAAGGATATGGAGTTAAGTCATCTAAGAAGTAGGCA
ACAAGATAAAATATATGTGGGTGAAGATGCTAGAAATGTGACAGTTCTGGCAAAAACAAAGTTCTCCCAAGATTTCAGCACGTTTGCAGC
GGAAATTCAGGAAACCATCACAGCACTCAGAGAGCAGATAAACAAGCTGGAGGCACGCCTGAGGCAGGCAGGGTGTACAGATGTTAGAGG
GGTTCCAAGGAAGGCCGAGGAGCGCTGGATGAAAGAAGACTGCACTCACTGCATTTGTGAGAGTGGCCAGGTCACCTGTGTGGTGGAGAT
TTGTCCCCCGGCTCCCTGTCCCAGTCCTGAATTGGTGAAAGGAACCTGCTGTCCAGTTTGCAGAGACCGAGGAATGCCAAGTGATTCCCC
AGAGAAGCGCTAATAAAAGTTTTGTGCTGTTGAGCCCCAAATGGGAAATTTCTCAGGAAGAGACATTTAGGACTTCAGAACTTTTAACTT
GTAGTCACATTGTTGATATGGAAACCACTGACTTAAGCAACTTAGTTCATCTAATCTTACATATACTTACGATCTTTTATTTTTTCATTT
TCTAACATACCTTGAAATAATTCAAAACTAAAAGCAATAAAGTGCATATGAAGTGTTTGATCATAAGAAATATTTCTTACTGTAAGCTGT

>93236_93236_4_TP53-PXDNL_TP53_chr17_7577499_ENST00000420246_PXDNL_chr8_52567320_ENST00000356297_length(amino acids)=1704AA_BP=295
MLGSGDTLRSGWERAFHDGDTLPWIGSQTAFRVTAMEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFT
EDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQL
WVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYN
YMCNSSCMGGMNRRPILTIITLEDSRDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFK
GLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAAT
CEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESD
QGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNIT
QRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAA
QHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYD
AGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMA
RAGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTWGAALTAF
ARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTND
PPCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPS
GKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLP
KVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAA
KWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPA
LMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPK
VDLRVWQDCCADCRSRGQFRAVTQESQKKRSAQYSYPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITAL

--------------------------------------------------------------
>93236_93236_5_TP53-PXDNL_TP53_chr17_7577499_ENST00000445888_PXDNL_chr8_52567320_ENST00000543296_length(transcript)=5207nt_BP=918nt
AAAAGTCTAGAGCCACCGTCCAGGGAGCAGGTAGCTGCTGGGCTCCGGGGACACTTTGCGTTCGGGCTGGGAGCGTGCTTTCCACGACGG
TGACACGCTTCCCTGGATTGGCCAGACTGCCTTCCGGGTCACTGCCATGGAGGAGCCGCAGTCAGATCCTAGCGTCGAGCCCCCTCTGAG
TCAGGAAACATTTTCAGACCTATGGAAACTACTTCCTGAAAACAACGTTCTGTCCCCCTTGCCGTCCCAAGCAATGGATGATTTGATGCT
GTCCCCGGACGATATTGAACAATGGTTCACTGAAGACCCAGGTCCAGATGAAGCTCCCAGAATGCCAGAGGCTGCTCCCCCCGTGGCCCC
TGCACCAGCAGCTCCTACACCGGCGGCCCCTGCACCAGCCCCCTCCTGGCCCCTGTCATCTTCTGTCCCTTCCCAGAAAACCTACCAGGG
CAGCTACGGTTTCCGTCTGGGCTTCTTGCATTCTGGGACAGCCAAGTCTGTGACTTGCACGTACTCCCCTGCCCTCAACAAGATGTTTTG
CCAACTGGCCAAGACCTGCCCTGTGCAGCTGTGGGTTGATTCCACACCCCCGCCCGGCACCCGCGTCCGCGCCATGGCCATCTACAAGCA
GTCACAGCACATGACGGAGGTTGTGAGGCGCTGCCCCCACCATGAGCGCTGCTCAGATAGCGATGGTCTGGCCCCTCCTCAGCATCTTAT
CCGAGTGGAAGGAAATTTGCGTGTGGAGTATTTGGATGACAGAAACACTTTTCGACATAGTGTGGTGGTGCCCTATGAGCCGCCTGAGGT
TGGCTCTGACTGTACCACCATCCACTACAACTACATGTGTAACAGTTCCTGCATGGGCGGCATGAACCGGAGGCCCATCCTCACCATCAT
CACACTGGAAGACTCCAGAGACTTGAGGTTTAACAGAATAAGAGAAATTCCAGGGAGCGCCTTCAAGAAACTCAAGAATTTGAACACACT
TCTGCTGAACAACAACCACATCAGAAAGATTTCCAGAAATGCTTTTGAAGGACTTGAAAATTTGCTATATCTGTACCTGTATAAGAATGA
AATCCATGCACTAGATAAGCAAACATTTAAAGGACTCATATCTTTGGAACATCTGTATATTCATTTCAACCAACTAGAAATGCTACAGCC
AGAGACCTTTGGAGACCTTCTGAGATTAGAGCGACTATTTTTGCATAACAACAAATTATCTAAAATTCCAGCTGGGAGCTTTTCTAATCT
GGATTCATTAAAAAGATTGCGTCTGGATTCCAACGCCCTGGTTTGTGACTGTGATCTGATGTGGCTGGGGGAGCTTTTACAAGGCTTTGC
CCAACACGGCCACACCCAGGCTGCGGCTACCTGCGAATATCCCAGGAGACTCCATGGGCGTGCAGTTGCTTCAGTAACAGTAGAGGAATT
CAATTGCCAGAGCCCCCGAATTACTTTTGAGCCGCAGGATGTGGAGGTACCATCAGGAAATACCGTCTACTTCACCTGCCGGGCGGAAGG
AAACCCCAAACCTGAGATTATTTGGATACACAACAACCACTCATTGGATTTGGAAGATGATACTCGACTTAATGTGTTTGATGATGGCAC
ACTCATGATCCGAAACACCAGAGAGTCAGACCAAGGTGTCTATCAGTGCATGGCCAGAAATTCCGCTGGGGAAGCCAAGACACAGAGTGC
CATGCTCAGATACTCCAGTCTTCCAGCCAAACCAAGCTTTGTAATCCAGCCTCAGGACACAGAGGTTTTAATTGGCACCAGCACAACTTT
GGAATGTATGGCCACAGGCCACCCACACCCTCTTATCACTTGGACCAGGGACAATGGATTGGAGCTGGATGGATCCAGGCACGTGGCAAC
GTCCAGTGGACTTTACTTACAGAACATCACACAACGGGATCATGGTCGATTTACCTGTCATGCCAACAATAGCCACGGCACTGTTCAAGC
TGCAGCAAACATAATTGTACAAGCTCCTCCACAATTTACAGTAACCCCCAAGGATCAAGTGGTGCTGGAAGAACATGCTGTAGAGTGGCT
CTGTGAAGCTGACGGCAACCCACCTCCTGTTATTGTCTGGACAAAAACAGGAGGGCAGCTCCCTGTGGAAGGCCAGCATACAGTTCTCTC
CTCTGGCACTTTGAGAATTGACCGTGCAGCACAGCACGATCAAGGCCAATATGAATGTCAAGCAGTCAGTTCGTTGGGGGTGAAAAAGGT
GTCTGTGCAGCTGACTGTAAAACCCAAAGCTCTTGCAGTGTTTACTCAACTTCCTCAGGATACAAGTGTCGAGGTTGGAAAGAATATAAA
CATTTCATGTCATGCTCAAGGAGAACCACAGCCCATAATTACTTGGAATAAGGAAGGTGTGCAGATTACTGAGAGTGGTAAATTCCATGT
GGATGATGAAGGCACGCTGACTATCTACGACGCAGGGTTCCCTGACCAGGGAAGATATGAATGTGTGGCTCGGAATTCTTTTGGCCTTGC
TGTGACCAACATGTTTCTTACAGTCACGGCTATACAGGGTAGACAAGCTGGCGATGACTTTGTTGAATCTTCCATTCTTGATGCTGTACA
GAGAGTTGACAGTGCAATTAACTCCACACGAAGACATTTGTTTTCACAAAAACCTCACACCTCCAGTGACCTGCTGGCTCAATTTCATTA
CCCGCGTGACCCACTGATTGTGGAAATGGCAAGAGCAGGGGAGATTTTTGAGCACACGCTGCAGCTGATACGGGAACGTGTGAAGCAGGG
GCTCACTGTGGACTTGGAAGGCAAAGAATTCCGGTACAATGACTTGGTGTCCCCGCGCTCCCTCAGCCTCATCGCCAATTTATCTGGATG
CACAGCTCGCAGGCCTCTGCCAAACTGCTCCAACCGGTGTTTCCATGCGAAGTACCGCGCCCACGACGGCACGTGCAACAACCTGCAGCA
GCCCACGTGGGGCGCGGCGCTGACCGCCTTCGCGCGCCTGCTGCAGCCAGCCTACCGGGACGGCATCCGCGCGCCCCGCGGGCTCGGCCT
TCCTGTGGGCTCCCGCCAGCCCCTCCCGCCGCCCCGGCTGGTCGCCACAGTGTGGGCGCGCGCGGCGGCCGTCACCCCCGACCACAGCTA
CACGCGCATGCTCATGCACTGGGGCTGGTTTCTAGAGCACGACTTGGACCACACAGTGCCTGCGCTGAGCACAGCCCGCTTCTCGGATGG
GCGGCCGTGCAGCTCCGTCTGCACCAACGACCCTCCTTGTTTCCCCATGAACACCCGGCACGCCGACCCCCGGGGCACCCACGCGCCCTG
CATGCTCTTCGCGCGCTCCAGCCCCGCGTGTGCCAGCGGCCGTCCCTCTGCGACGGTGGATTCAGTCTATGCACGAGAGCAGATCAACCA
GCAAACAGCCTACATCGATGGCTCCAACGTTTACGGGAGCTCGGAGCGGGAATCCCAGGCTCTCAGAGACCCTTCGGTGCCTCGGGGTCT
CCTGAAGACAGGCTTTCCTTGGCCTCCCTCCGGAAAGCCCTTATTGCCCTTTTCTACAGGCCCACCCACCGAGTGCGCGCGACAGGAGCA
GGAGAGCCCCTGTTTCCTGGCCGGGGACCACCGGGCCAACGAGCATCTGGCTCTGGCCGCCATGCACACCCTGTGGTTCCGGGAACACAA
CAGGATGGCCACGGAGCTGTCCGCCCTGAACCCCCACTGGGAGGGAAACACGGTTTACCAGGAAGCCAGGAAGATCGTGGGCGCGGAGCT
GCAGCACATCACCTACAGCCACTGGCTGCCTAAGGTCCTGGGGGACCCTGGCACTAGGATGCTGAGGGGTTACCGAGGCTACAACCCCAA
CGTGAATGCAGGCATCATTAACTCTTTTGCTACTGCAGCCTTTAGATTTGGCCACACATTAATCAATCCTATTCTTTACCGACTGAATGC
CACCTTAGGTGAAATTTCCGAAGGCCACCTTCCGTTCCATAAAGCGCTCTTTTCACCGTCCAGAATAATCAAGGAAGGTGGGATAGACCC
GGTTCTCCGGGGGCTGTTTGGCGTGGCTGCTAAATGGCGGGCACCCTCCTACCTTCTCAGTCCTGAGCTGACCCAGAGGCTCTTCTCCGC
GGCTTATTCTGCGGCCGTGGATTCGGCTGCCACCATCATTCAAAGGGGTAGAGACCACGGGATCCCACCATATGTTGACTTCAGAGTTTT
CTGTAATTTGACTTCAGTTAAGAACTTTGAGGATCTTCAAAATGAAATTAAAGATTCAGAGATTAGACAAAAACTGAGAAAGTTGTACGG
CTCTCCAGGTGACATTGACCTCTGGCCCGCCCTTATGGTTGAAGACCTGATTCCTGGTACAAGAGTGGGACCAACACTTATGTGCCTGTT
TGTTACCCAGTTTCAGCGGCTAAGAGATGGAGATAGGTTCTGGTATGAAAACCCTGGAGTATTTACCCCGGCACAACTCACTCAGCTGAA
GCAGGCGTCCCTGAGCCGGGTGCTTTGTGACAATGGTGACAGCATTCAGCAAGTGCAGGCTGATGTCTTTGTAAAGGCAGAATACCCACA
GGATTACCTGAACTGCAGCGAGATCCCGAAGGTGGACCTGCGAGTGTGGCAAGACTGCTGTGCAGATAAACAAGCTGGAGGCACGCCTGA
GGCAGGCAGGGTGTACAGATGTTAGAGGGGTTCCAAGGAAGGCCGAGGAGCGCTGGATGAAAGAAGACTGCACTCACTGCATTTGTGAGA
GTGGCCAGGTCACCTGTGTGGTGGAGATTTGTCCCCCGGCTCCCTGTCCCAGTCCTGAATTGGTGAAAGGAACCTGCTGTCCAGTTTGCA
GAGACCGAGGAATGCCAAGTGATTCCCCAGAGAAGCGCTAATAAAAGTTTTGTGCTGTTGAGCCCCAAATGGGAAATTTCTCAGGAAGAG
ACATTTAGGACTTCAGAACTTTTAACTTGTAGTCACATTGTTGATATGGAAACCACTGACTTAAGCAACTTAGTTCATCTAATCTTACAT
ATACTTACGATCTTTTATTTTTTCATTTTCTAACATACCTTGAAATAATTCAAAACTAAAAGCAATAAAGTGCATATGAAGTGTTTGATC

>93236_93236_5_TP53-PXDNL_TP53_chr17_7577499_ENST00000445888_PXDNL_chr8_52567320_ENST00000543296_length(amino acids)=1556AA_BP=294
MLGSGDTLRSGWERAFHDGDTLPWIGQTAFRVTAMEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTE
DPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLW
VDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNY
MCNSSCMGGMNRRPILTIITLEDSRDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKG
LISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATC
EYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQ
GVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQ
RDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQ
HDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDA
GFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMAR
AGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTWGAALTAFA
RLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDP
PCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSG
KPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPK
VLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAK
WRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPAL
MVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKV

--------------------------------------------------------------
>93236_93236_6_TP53-PXDNL_TP53_chr17_7577499_ENST00000455263_PXDNL_chr8_52567320_ENST00000356297_length(transcript)=5455nt_BP=915nt
CTAGAGCCACCGTCCAGGGAGCAGGTAGCTGCTGGGCTCCGGGGACACTTTGCGTTCGGGCTGGGAGCGTGCTTTCCACGACGGTGACAC
GCTTCCCTGGATTGGCAGCCAGACTGCCTTCCGGGTCACTGCCATGGAGGAGCCGCAGTCAGATCCTAGCGTCGAGCCCCCTCTGAGTCA
GGAAACATTTTCAGACCTATGGAAACTACTTCCTGAAAACAACGTTCTGTCCCCCTTGCCGTCCCAAGCAATGGATGATTTGATGCTGTC
CCCGGACGATATTGAACAATGGTTCACTGAAGACCCAGGTCCAGATGAAGCTCCCAGAATGCCAGAGGCTGCTCCCCCCGTGGCCCCTGC
ACCAGCAGCTCCTACACCGGCGGCCCCTGCACCAGCCCCCTCCTGGCCCCTGTCATCTTCTGTCCCTTCCCAGAAAACCTACCAGGGCAG
CTACGGTTTCCGTCTGGGCTTCTTGCATTCTGGGACAGCCAAGTCTGTGACTTGCACGTACTCCCCTGCCCTCAACAAGATGTTTTGCCA
ACTGGCCAAGACCTGCCCTGTGCAGCTGTGGGTTGATTCCACACCCCCGCCCGGCACCCGCGTCCGCGCCATGGCCATCTACAAGCAGTC
ACAGCACATGACGGAGGTTGTGAGGCGCTGCCCCCACCATGAGCGCTGCTCAGATAGCGATGGTCTGGCCCCTCCTCAGCATCTTATCCG
AGTGGAAGGAAATTTGCGTGTGGAGTATTTGGATGACAGAAACACTTTTCGACATAGTGTGGTGGTGCCCTATGAGCCGCCTGAGGTTGG
CTCTGACTGTACCACCATCCACTACAACTACATGTGTAACAGTTCCTGCATGGGCGGCATGAACCGGAGGCCCATCCTCACCATCATCAC
ACTGGAAGACTCCAGAGACTTGAGGTTTAACAGAATAAGAGAAATTCCAGGGAGCGCCTTCAAGAAACTCAAGAATTTGAACACACTTCT
GCTGAACAACAACCACATCAGAAAGATTTCCAGAAATGCTTTTGAAGGACTTGAAAATTTGCTATATCTGTACCTGTATAAGAATGAAAT
CCATGCACTAGATAAGCAAACATTTAAAGGACTCATATCTTTGGAACATCTGTATATTCATTTCAACCAACTAGAAATGCTACAGCCAGA
GACCTTTGGAGACCTTCTGAGATTAGAGCGACTATTTTTGCATAACAACAAATTATCTAAAATTCCAGCTGGGAGCTTTTCTAATCTGGA
TTCATTAAAAAGATTGCGTCTGGATTCCAACGCCCTGGTTTGTGACTGTGATCTGATGTGGCTGGGGGAGCTTTTACAAGGCTTTGCCCA
ACACGGCCACACCCAGGCTGCGGCTACCTGCGAATATCCCAGGAGACTCCATGGGCGTGCAGTTGCTTCAGTAACAGTAGAGGAATTCAA
TTGCCAGAGCCCCCGAATTACTTTTGAGCCGCAGGATGTGGAGGTACCATCAGGAAATACCGTCTACTTCACCTGCCGGGCGGAAGGAAA
CCCCAAACCTGAGATTATTTGGATACACAACAACCACTCATTGGATTTGGAAGATGATACTCGACTTAATGTGTTTGATGATGGCACACT
CATGATCCGAAACACCAGAGAGTCAGACCAAGGTGTCTATCAGTGCATGGCCAGAAATTCCGCTGGGGAAGCCAAGACACAGAGTGCCAT
GCTCAGATACTCCAGTCTTCCAGCCAAACCAAGCTTTGTAATCCAGCCTCAGGACACAGAGGTTTTAATTGGCACCAGCACAACTTTGGA
ATGTATGGCCACAGGCCACCCACACCCTCTTATCACTTGGACCAGGGACAATGGATTGGAGCTGGATGGATCCAGGCACGTGGCAACGTC
CAGTGGACTTTACTTACAGAACATCACACAACGGGATCATGGTCGATTTACCTGTCATGCCAACAATAGCCACGGCACTGTTCAAGCTGC
AGCAAACATAATTGTACAAGCTCCTCCACAATTTACAGTAACCCCCAAGGATCAAGTGGTGCTGGAAGAACATGCTGTAGAGTGGCTCTG
TGAAGCTGACGGCAACCCACCTCCTGTTATTGTCTGGACAAAAACAGGAGGGCAGCTCCCTGTGGAAGGCCAGCATACAGTTCTCTCCTC
TGGCACTTTGAGAATTGACCGTGCAGCACAGCACGATCAAGGCCAATATGAATGTCAAGCAGTCAGTTCGTTGGGGGTGAAAAAGGTGTC
TGTGCAGCTGACTGTAAAACCCAAAGCTCTTGCAGTGTTTACTCAACTTCCTCAGGATACAAGTGTCGAGGTTGGAAAGAATATAAACAT
TTCATGTCATGCTCAAGGAGAACCACAGCCCATAATTACTTGGAATAAGGAAGGTGTGCAGATTACTGAGAGTGGTAAATTCCATGTGGA
TGATGAAGGCACGCTGACTATCTACGACGCAGGGTTCCCTGACCAGGGAAGATATGAATGTGTGGCTCGGAATTCTTTTGGCCTTGCTGT
GACCAACATGTTTCTTACAGTCACGGCTATACAGGGTAGACAAGCTGGCGATGACTTTGTTGAATCTTCCATTCTTGATGCTGTACAGAG
AGTTGACAGTGCAATTAACTCCACACGAAGACATTTGTTTTCACAAAAACCTCACACCTCCAGTGACCTGCTGGCTCAATTTCATTACCC
GCGTGACCCACTGATTGTGGAAATGGCAAGAGCAGGGGAGATTTTTGAGCACACGCTGCAGCTGATACGGGAACGTGTGAAGCAGGGGCT
CACTGTGGACTTGGAAGGCAAAGAATTCCGGTACAATGACTTGGTGTCCCCGCGCTCCCTCAGCCTCATCGCCAATTTATCTGGATGCAC
AGCTCGCAGGCCTCTGCCAAACTGCTCCAACCGGTGTTTCCATGCGAAGTACCGCGCCCACGACGGCACGTGCAACAACCTGCAGCAGCC
CACGTGGGGCGCGGCGCTGACCGCCTTCGCGCGCCTGCTGCAGCCAGCCTACCGGGACGGCATCCGCGCGCCCCGCGGGCTCGGCCTTCC
TGTGGGCTCCCGCCAGCCCCTCCCGCCGCCCCGGCTGGTCGCCACAGTGTGGGCGCGCGCGGCGGCCGTCACCCCCGACCACAGCTACAC
GCGCATGCTCATGCACTGGGGCTGGTTTCTAGAGCACGACTTGGACCACACAGTGCCTGCGCTGAGCACAGCCCGCTTCTCGGATGGGCG
GCCGTGCAGCTCCGTCTGCACCAACGACCCTCCTTGTTTCCCCATGAACACCCGGCACGCCGACCCCCGGGGCACCCACGCGCCCTGCAT
GCTCTTCGCGCGCTCCAGCCCCGCGTGTGCCAGCGGCCGTCCCTCTGCGACGGTGGATTCAGTCTATGCACGAGAGCAGATCAACCAGCA
AACAGCCTACATCGATGGCTCCAACGTTTACGGGAGCTCGGAGCGGGAATCCCAGGCTCTCAGAGACCCTTCGGTGCCTCGGGGTCTCCT
GAAGACAGGCTTTCCTTGGCCTCCCTCCGGAAAGCCCTTATTGCCCTTTTCTACAGGCCCACCCACCGAGTGCGCGCGACAGGAGCAGGA
GAGCCCCTGTTTCCTGGCCGGGGACCACCGGGCCAACGAGCATCTGGCTCTGGCCGCCATGCACACCCTGTGGTTCCGGGAACACAACAG
GATGGCCACGGAGCTGTCCGCCCTGAACCCCCACTGGGAGGGAAACACGGTTTACCAGGAAGCCAGGAAGATCGTGGGCGCGGAGCTGCA
GCACATCACCTACAGCCACTGGCTGCCTAAGGTCCTGGGGGACCCTGGCACTAGGATGCTGAGGGGTTACCGAGGCTACAACCCCAACGT
GAATGCAGGCATCATTAACTCTTTTGCTACTGCAGCCTTTAGATTTGGCCACACATTAATCAATCCTATTCTTTACCGACTGAATGCCAC
CTTAGGTGAAATTTCCGAAGGCCACCTTCCGTTCCATAAAGCGCTCTTTTCACCGTCCAGAATAATCAAGGAAGGTGGGATAGACCCGGT
TCTCCGGGGGCTGTTTGGCGTGGCTGCTAAATGGCGGGCACCCTCCTACCTTCTCAGTCCTGAGCTGACCCAGAGGCTCTTCTCCGCGGC
TTATTCTGCGGCCGTGGATTCGGCTGCCACCATCATTCAAAGGGGTAGAGACCACGGGATCCCACCATATGTTGACTTCAGAGTTTTCTG
TAATTTGACTTCAGTTAAGAACTTTGAGGATCTTCAAAATGAAATTAAAGATTCAGAGATTAGACAAAAACTGAGAAAGTTGTACGGCTC
TCCAGGTGACATTGACCTCTGGCCCGCCCTTATGGTTGAAGACCTGATTCCTGGTACAAGAGTGGGACCAACACTTATGTGCCTGTTTGT
TACCCAGTTTCAGCGGCTAAGAGATGGAGATAGGTTCTGGTATGAAAACCCTGGAGTATTTACCCCGGCACAACTCACTCAGCTGAAGCA
GGCGTCCCTGAGCCGGGTGCTTTGTGACAATGGTGACAGCATTCAGCAAGTGCAGGCTGATGTCTTTGTAAAGGCAGAATACCCACAGGA
TTACCTGAACTGCAGCGAGATCCCGAAGGTGGACCTGCGAGTGTGGCAAGACTGCTGTGCAGACTGTAGGAGTAGAGGACAGTTCAGAGC
AGTGACGCAAGAGTCTCAAAAGAAACGCTCAGCTCAATACAGCTATCCTGTTGATAAGGATATGGAGTTAAGTCATCTAAGAAGTAGGCA
ACAAGATAAAATATATGTGGGTGAAGATGCTAGAAATGTGACAGTTCTGGCAAAAACAAAGTTCTCCCAAGATTTCAGCACGTTTGCAGC
GGAAATTCAGGAAACCATCACAGCACTCAGAGAGCAGATAAACAAGCTGGAGGCACGCCTGAGGCAGGCAGGGTGTACAGATGTTAGAGG
GGTTCCAAGGAAGGCCGAGGAGCGCTGGATGAAAGAAGACTGCACTCACTGCATTTGTGAGAGTGGCCAGGTCACCTGTGTGGTGGAGAT
TTGTCCCCCGGCTCCCTGTCCCAGTCCTGAATTGGTGAAAGGAACCTGCTGTCCAGTTTGCAGAGACCGAGGAATGCCAAGTGATTCCCC
AGAGAAGCGCTAATAAAAGTTTTGTGCTGTTGAGCCCCAAATGGGAAATTTCTCAGGAAGAGACATTTAGGACTTCAGAACTTTTAACTT
GTAGTCACATTGTTGATATGGAAACCACTGACTTAAGCAACTTAGTTCATCTAATCTTACATATACTTACGATCTTTTATTTTTTCATTT
TCTAACATACCTTGAAATAATTCAAAACTAAAAGCAATAAAGTGCATATGAAGTGTTTGATCATAAGAAATATTTCTTACTGTAAGCTGT

>93236_93236_6_TP53-PXDNL_TP53_chr17_7577499_ENST00000455263_PXDNL_chr8_52567320_ENST00000356297_length(amino acids)=1704AA_BP=295
MLGSGDTLRSGWERAFHDGDTLPWIGSQTAFRVTAMEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFT
EDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQL
WVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYN
YMCNSSCMGGMNRRPILTIITLEDSRDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFK
GLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAAT
CEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESD
QGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNIT
QRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAA
QHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYD
AGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMA
RAGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTWGAALTAF
ARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTND
PPCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPS
GKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLP
KVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAA
KWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPA
LMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPK
VDLRVWQDCCADCRSRGQFRAVTQESQKKRSAQYSYPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITAL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TP53-PXDNL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-7111_83260.6666666666667394.0HRMT1L2
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-7121_83260.6666666666667774.6666666666666HRMT1L2
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-7111_83260.6666666666667394.0HRMT1L2
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-7121_83260.6666666666667755.3333333333334HRMT1L2
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-711241_248260.6666666666667394.0the 53BP2 SH3 domain
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-712241_248260.6666666666667774.6666666666666the 53BP2 SH3 domain
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-711241_248260.6666666666667394.0the 53BP2 SH3 domain
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-712241_248260.6666666666667755.3333333333334the 53BP2 SH3 domain
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-71166_110260.6666666666667394.0WWOX
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-71266_110260.6666666666667774.6666666666666WWOX
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-71166_110260.6666666666667394.0WWOX
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-71266_110260.6666666666667755.3333333333334WWOX


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-711116_292260.6666666666667394.0AXIN1
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-712116_292260.6666666666667774.6666666666666AXIN1
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-711116_292260.6666666666667394.0AXIN1
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-712116_292260.6666666666667755.3333333333334AXIN1
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-711300_393260.6666666666667394.0CARM1
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-712300_393260.6666666666667774.6666666666666CARM1
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-711300_393260.6666666666667394.0CARM1
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-712300_393260.6666666666667755.3333333333334CARM1
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-7111_320260.6666666666667394.0CCAR2
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-7121_320260.6666666666667774.6666666666666CCAR2
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-7111_320260.6666666666667394.0CCAR2
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-7121_320260.6666666666667755.3333333333334CCAR2
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-711273_280260.6666666666667394.0DNA
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-712273_280260.6666666666667774.6666666666666DNA
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-711273_280260.6666666666667394.0DNA
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-712273_280260.6666666666667755.3333333333334DNA
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-711256_294260.6666666666667394.0E4F1
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-712256_294260.6666666666667774.6666666666666E4F1
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-711256_294260.6666666666667394.0E4F1
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-712256_294260.6666666666667755.3333333333334E4F1
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-711100_370260.6666666666667394.0HIPK1
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-712100_370260.6666666666667774.6666666666666HIPK1
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-711100_370260.6666666666667394.0HIPK1
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-712100_370260.6666666666667755.3333333333334HIPK1
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-711319_360260.6666666666667394.0HIPK2
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-712319_360260.6666666666667774.6666666666666HIPK2
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-711319_360260.6666666666667394.0HIPK2
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-712319_360260.6666666666667755.3333333333334HIPK2
HgeneTP53chr17:7577499chr8:52567320ENST00000269305-711359_363260.6666666666667394.0USP7
HgeneTP53chr17:7577499chr8:52567320ENST00000420246-712359_363260.6666666666667774.6666666666666USP7
HgeneTP53chr17:7577499chr8:52567320ENST00000445888-711359_363260.6666666666667394.0USP7
HgeneTP53chr17:7577499chr8:52567320ENST00000455263-712359_363260.6666666666667755.3333333333334USP7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TP53-PXDNL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TP53-PXDNL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource