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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TPCN1-OAS3 (FusionGDB2 ID:93265)

Fusion Gene Summary for TPCN1-OAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: TPCN1-OAS3
Fusion gene ID: 93265
HgeneTgene
Gene symbol

TPCN1

OAS3

Gene ID

53373

4940

Gene nametwo pore segment channel 12'-5'-oligoadenylate synthetase 3
SynonymsTPC1p100|p100OAS
Cytomap

12q24.13

12q24.13

Type of geneprotein-codingprotein-coding
Descriptiontwo pore calcium channel protein 1two-pore channel 1, homologvoltage-dependent calcium channel protein TPC12'-5'-oligoadenylate synthase 3(2-5')oligo(A) synthase 3(2-5')oligo(A) synthetase 32'-5'-oligoadenylate synthetase 3, 100kDa2'-5'oligoadenylate synthetase p1002-5A synthase 32-5A synthetase 3p100 OAS
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000335509, ENST00000541517, 
ENST00000550785, ENST00000392569, 
ENST00000546787, 		ENST00000546638, 
ENST00000548514, ENST00000551007, 
ENST00000228928, 
Fusion gene scores* DoF score11 X 9 X 5=4953 X 3 X 3=27
# samples 113
** MAII scorelog2(11/495*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TPCN1 [Title/Abstract] AND OAS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTPCN1(113664769)-OAS3(113405223), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTPCN1

GO:0010508

positive regulation of autophagy

22012985

TgeneOAS3

GO:0009615

response to virus

19056102

TgeneOAS3

GO:0045071

negative regulation of viral genome replication

19056102|19923450

TgeneOAS3

GO:0051607

defense response to virus

19923450

TgeneOAS3

GO:0060700

regulation of ribonuclease activity

19923450


check buttonFusion gene breakpoints across TPCN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across OAS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8527-01ATPCN1chr12

113664769

+OAS3chr12

113405223

+


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Fusion Gene ORF analysis for TPCN1-OAS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000335509ENST00000546638TPCN1chr12

113664769

+OAS3chr12

113405223

+
5CDS-intronENST00000335509ENST00000548514TPCN1chr12

113664769

+OAS3chr12

113405223

+
5CDS-intronENST00000335509ENST00000551007TPCN1chr12

113664769

+OAS3chr12

113405223

+
5CDS-intronENST00000541517ENST00000546638TPCN1chr12

113664769

+OAS3chr12

113405223

+
5CDS-intronENST00000541517ENST00000548514TPCN1chr12

113664769

+OAS3chr12

113405223

+
5CDS-intronENST00000541517ENST00000551007TPCN1chr12

113664769

+OAS3chr12

113405223

+
5CDS-intronENST00000550785ENST00000546638TPCN1chr12

113664769

+OAS3chr12

113405223

+
5CDS-intronENST00000550785ENST00000548514TPCN1chr12

113664769

+OAS3chr12

113405223

+
5CDS-intronENST00000550785ENST00000551007TPCN1chr12

113664769

+OAS3chr12

113405223

+
In-frameENST00000335509ENST00000228928TPCN1chr12

113664769

+OAS3chr12

113405223

+
In-frameENST00000541517ENST00000228928TPCN1chr12

113664769

+OAS3chr12

113405223

+
In-frameENST00000550785ENST00000228928TPCN1chr12

113664769

+OAS3chr12

113405223

+
intron-3CDSENST00000392569ENST00000228928TPCN1chr12

113664769

+OAS3chr12

113405223

+
intron-3CDSENST00000546787ENST00000228928TPCN1chr12

113664769

+OAS3chr12

113405223

+
intron-intronENST00000392569ENST00000546638TPCN1chr12

113664769

+OAS3chr12

113405223

+
intron-intronENST00000392569ENST00000548514TPCN1chr12

113664769

+OAS3chr12

113405223

+
intron-intronENST00000392569ENST00000551007TPCN1chr12

113664769

+OAS3chr12

113405223

+
intron-intronENST00000546787ENST00000546638TPCN1chr12

113664769

+OAS3chr12

113405223

+
intron-intronENST00000546787ENST00000548514TPCN1chr12

113664769

+OAS3chr12

113405223

+
intron-intronENST00000546787ENST00000551007TPCN1chr12

113664769

+OAS3chr12

113405223

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000335509TPCN1chr12113664769+ENST00000228928OAS3chr12113405223+42774262901000236
ENST00000550785TPCN1chr12113664769+ENST00000228928OAS3chr12113405223+43484971691071300
ENST00000541517TPCN1chr12113664769+ENST00000228928OAS3chr12113405223+41813302904300

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000335509ENST00000228928TPCN1chr12113664769+OAS3chr12113405223+0.0084317350.99156827
ENST00000550785ENST00000228928TPCN1chr12113664769+OAS3chr12113405223+0.0174666920.9825333
ENST00000541517ENST00000228928TPCN1chr12113664769+OAS3chr12113405223+0.0152670990.9847329

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Fusion Genomic Features for TPCN1-OAS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TPCN1chr12113664769+OAS3chr12113405222+0.0001717150.9998282
TPCN1chr12113664769+OAS3chr12113405222+0.0001717150.9998282

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TPCN1-OAS3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:113664769/chr12:113405223)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+2281_112109889.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+3291_112109889.0Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228769_79637817.0Coiled coilOntology_term=ECO:0000255
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228769_796109889.0Coiled coilOntology_term=ECO:0000255
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329769_796109889.0Coiled coilOntology_term=ECO:0000255
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228263_28637817.0IntramembraneHelical%3B Pore-forming
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228630_65337817.0IntramembraneHelical%3B Pore-forming
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228263_286109889.0IntramembraneHelical%3B Pore-forming
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228630_653109889.0IntramembraneHelical%3B Pore-forming
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329263_286109889.0IntramembraneHelical%3B Pore-forming
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329630_653109889.0IntramembraneHelical%3B Pore-forming
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228134_13437817.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228156_17737817.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228199_20037817.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+2281_11237817.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228221_23437817.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228256_26237817.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228287_29437817.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228316_44437817.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228466_47937817.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228501_50337817.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228527_53437817.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228550_57337817.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228595_62937817.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228654_67037817.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228692_81637817.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228134_134109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228156_177109889.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228199_200109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228221_234109889.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228256_262109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228287_294109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228316_444109889.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228466_479109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228501_503109889.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228527_534109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228550_573109889.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228595_629109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228654_670109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228692_816109889.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329134_134109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329156_177109889.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329199_200109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329221_234109889.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329256_262109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329287_294109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329316_444109889.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329466_479109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329501_503109889.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329527_534109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329550_573109889.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329595_629109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329654_670109889.0Topological domainExtracellular
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329692_816109889.0Topological domainCytoplasmic
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228113_13337817.0TransmembraneHelical%3B Name%3DS1 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228135_15537817.0TransmembraneHelical%3B Name%3DS2 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228178_19837817.0TransmembraneHelical%3B Name%3DS3 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228201_22037817.0TransmembraneHelical%3B Name%3DS4 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228235_25537817.0TransmembraneHelical%3B Name%3DS5 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228295_31537817.0TransmembraneHelical%3B Name%3DS6 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228445_46537817.0TransmembraneHelical%3B Name%3DS1 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228480_50037817.0TransmembraneHelical%3B Name%3DS2 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228504_52637817.0TransmembraneHelical%3B Name%3DS3 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228535_54937817.0TransmembraneHelical%3B Name%3DS4 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228574_59437817.0TransmembraneHelical%3B Name%3DS5 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000335509+228671_69137817.0TransmembraneHelical%3B Name%3DS6 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228113_133109889.0TransmembraneHelical%3B Name%3DS1 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228135_155109889.0TransmembraneHelical%3B Name%3DS2 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228178_198109889.0TransmembraneHelical%3B Name%3DS3 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228201_220109889.0TransmembraneHelical%3B Name%3DS4 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228235_255109889.0TransmembraneHelical%3B Name%3DS5 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228295_315109889.0TransmembraneHelical%3B Name%3DS6 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228445_465109889.0TransmembraneHelical%3B Name%3DS1 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228480_500109889.0TransmembraneHelical%3B Name%3DS2 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228504_526109889.0TransmembraneHelical%3B Name%3DS3 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228535_549109889.0TransmembraneHelical%3B Name%3DS4 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228574_594109889.0TransmembraneHelical%3B Name%3DS5 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000541517+228671_691109889.0TransmembraneHelical%3B Name%3DS6 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329113_133109889.0TransmembraneHelical%3B Name%3DS1 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329135_155109889.0TransmembraneHelical%3B Name%3DS2 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329178_198109889.0TransmembraneHelical%3B Name%3DS3 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329201_220109889.0TransmembraneHelical%3B Name%3DS4 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329235_255109889.0TransmembraneHelical%3B Name%3DS5 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329295_315109889.0TransmembraneHelical%3B Name%3DS6 of repeat I
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329445_465109889.0TransmembraneHelical%3B Name%3DS1 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329480_500109889.0TransmembraneHelical%3B Name%3DS2 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329504_526109889.0TransmembraneHelical%3B Name%3DS3 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329535_549109889.0TransmembraneHelical%3B Name%3DS4 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329574_594109889.0TransmembraneHelical%3B Name%3DS5 of repeat II
HgeneTPCN1chr12:113664769chr12:113405223ENST00000550785+329671_691109889.0TransmembraneHelical%3B Name%3DS6 of repeat II
TgeneOAS3chr12:113664769chr12:113405223ENST000002289281116344_4108961088.0RegionLinker
TgeneOAS3chr12:113664769chr12:113405223ENST000002289281116411_7428961088.0RegionOAS domain 2
TgeneOAS3chr12:113664769chr12:113405223ENST0000022892811166_3438961088.0RegionOAS domain 1
TgeneOAS3chr12:113664769chr12:113405223ENST000002289281116750_10848961088.0RegionOAS domain 3


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Fusion Gene Sequence for TPCN1-OAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93265_93265_1_TPCN1-OAS3_TPCN1_chr12_113664769_ENST00000335509_OAS3_chr12_113405223_ENST00000228928_length(transcript)=4277nt_BP=426nt
GAGAGGACGGTAGGCGGTGGATAGGAGAGCTGGCGCAGCTGCCCTGGTGGCAGTGGCTGAAGTGGCGGCGGCTTCGGCGGCTGCGGCGGC
TGCAACAGCTTCGGGCTCGGGGTTTTGGCGGCGGCGCCGGCGGGCTAGGCTGCGCGGTGCGGACCCCGGCGCGCGGTCCGGGTTGCTGGG
GCGGCGCGTAAGATGCCTCTAATGGAGGAGTTTCTGAGCAGCACCCCTGGCCCAGTGGCTTTGAAAGGGAGCTCAAACCAGAGACTATTT
CAAGCCCTGGATATCATATCCTGAGGGCCACAGGAGAAGAGAACATGGCTGTGAGTTTGGATGACGACGTGCCGCTCATCCTGACCTTGG
ATGAGGGTGGCAGTGCCCCACTGGCTCCCTCCAACGGCCTGGGCCAAGAAGAGCTACCTAGCAAAAGCCAGCTGGTCTCTGGCTCCAGGC
CCAGCTCTCAAGTCTACGTCGACCTCATCCACAGCTACAGCAATGCGGGCGAGTACTCCACCTGCTTCACAGAGCTACAACGGGACTTCA
TCATCTCTCGCCCTACCAAGCTGAAGAGCCTGATCCGGCTGGTGAAGCACTGGTACCAGCAGTGTACCAAGATCTCCAAGGGGAGAGGCT
CCCTACCCCCACAGCACGGGCTGGAACTCCTGACTGTGTATGCCTGGGAGCAGGGCGGGAAGGACTCCCAGTTCAACATGGCTGAGGGCT
TCCGCACGGTCCTGGAGCTGGTCACCCAGTACCGCCAGCTCTGTATCTACTGGACCATCAACTACAACGCCAAGGACAAGACTGTTGGAG
ACTTCCTGAAACAGCAGCTTCAGAAGCCCAGGCCTATCATCCTGGATCCGGCTGACCCGACAGGCAACCTGGGCCACAATGCCCGCTGGG
ACCTGCTGGCCAAGGAAGCTGCAGCCTGCACATCTGCCCTGTGCTGCATGGGACGGAATGGCATCCCCATCCAGCCATGGCCAGTGAAGG
CTGCTGTGTGAAGTTGAGAAAATCAGCGGTCCTACTGGATGAAGAGAAGATGGACACCAGCCCTCAGCATGAGGAAATTCAGGGTCCCCT
ACCAGATGAGAGAGATTGTGTACATGTGTGTGTGAGCACATGTGTGCATGTGTGTGCACACGTGTGCATGTGTGTGTTTTAGTGAATCTG
CTCTCCCAGCTCACACACTCCCCTGCCTCCCATGGCTTACACACTAGGATCCAGACTCCATGGTTTGACACCAGCCTGCGTTTGCAGCTT
CTCTGTCACTTCCATGACTCTATCCTCATACCACCACTGCTGCTTCCCACCCAGCTGAGAATGCCCCCTCCTCCCTGACTCCTCTCTGCC
CATGCAAATTAGCTCACATCTTTCCTCCTGCTGCAATCCATCCCTTCCTCCCATTGGCCTCTCCTTGCCAAATCTAAATAGTTTATATAG
GGATGGCAGAGAGTTCCCATCTCATCTGTCAGCCACAGTCATTTGGTACTGGCTACCTGGAGCCTTATCTTCTGAAGGGTTTTAAAGAAT
GGCCAATTAGCTGAGAAGAATTATCTAATCAATTAGTGATGTCTGCCATGGATGCAGTAGAGGAAAGTGGTGGTACAAGTGCCATGATTG
ATTAGCAATGTCTGCACTGGATACGGAAAAAAGAAGGTGCTTGCAGGTTTACAGTGTATATGTGGGCTATTGAAGAGCCCTCTGAGCTCG
GTTGCTAGCAGGAGAGCATGCCCATATTGGCTTACTTTGTCTGCCACAGACACAGACAGAGGGAGTTGGGACATGCATGCTATGGGGACC
CTCTTGTTGGACACCTAATTGGATGCCTCTTCATGAGAGGCCTCCTTTTCTTCACCTTTTATGCTGCACTCCTCCCCTAGTTTACACATC
TTGATGCTGTGGCTCAGTTTGCCTTCCTGAATTTTTATTGGGTCCCTGTTTTCTCTCCTAACATGCTGAGATTCTGCATCCCCACAGCCT
AAACTGAGCCAGTGGCCAAACAACCGTGCTCAGCCTGTTTCTCTCTGCCCTCTAGAGCAAGGCCCACCAGGTCCATCCAGGAGGCTCTCC
TGACCTCAAGTCCAACAACAGTGTCCACACTAGTCAAGGTTCAGCCCAGAAAACAGAAAGCACTCTAGGAATCTTAGGCAGAAAGGGATT
TTATCTAAATCACTGGAAAGGCTGGAGGAGCAGAAGGCAGAGGCCACCACTGGACTATTGGTTTCAATATTAGACCACTGTAGCCGAATC
AGAGGCCAGAGAGCAGCCACTGCTACTGCTAATGCCACCACTACCCCTGCCATCACTGCCCCACATGGACAAAACTGGAGTCGAGACCTA
GGTTAGATTCCTGCAACCACAAACATCCATCAGGGATGGCCAGCTGCCAGAGCTGCGGGAAGACGGATCCCACCTCCCTTTCTTAGCAGA
ATCTAAATTACAGCCAGACCTCTGGCTGCAGAGGAGTCTGAGACATGTATGATTGAATGGGTGCCAAGTGCCAGGGGGCGGAGTCCCCAG
CAGATGCATCCTGGCCATCTGTTGCGTGGATGAGGGAGTGGGTCTATCTCAGAGGAAGGAACAGGAAACAAAGAAAGGAAGCCACTGAAC
ATCCCTTCTCTGCTCCACAGGAGTGCCTTAGACAGCCTGACTCTCCACAAACCACTGTTAAAACTTACCTGCTAGGAATGCTAGATTGAA
TGGGATGGGAAGAGCCTTCCCTCATTATTGTCATTCTTGGAGAGAGGTGAGCAACCAAGGGAAGCTCCTCTGATTCACCTAGAACCTGTT
CTCTGCCGTCTTTGGCTCAGCCTACAGAGACTAGAGTAGGTGAAGGGACAGAGGACAGGGCTTCTAATACCTGTGCCATATTGACAGCCT
CCATCCCTGTCCCCCATCTTGGTGCTGAACCAACGCTAAGGGCACCTTCTTAGACTCACCTCATCGATACTGCCTGGTAATCCAAAGCTA
GAACTCTCAGGACCCCAAACTCCACCTCTTGGATTGGCCCTGGCTGCTGCCACACACATATCCAAGAGCTCAGGGCCAGTTCTGGTGGGC
AGCAGAGACCTGCTCTGCCAAGTTGTCCAGCAGCAGAGTGGCCCTGGCCTGGGCATCACAAGCCAGTGATGCTCCTGGGAAGACCAGGTG
GCAGGTCGCAGTTGGGTACCTTCCATTCCCACCACACAGACTCTGGGCCTCCCCGCAAAATGGCTCCAGAATTAGAGTAATTATGAGATG
GTGGGAACCAGAGCAACTCAGGTGCATGATACAAGGAGAGGTTGTCATCTGGGTAGGGCAGAGAGGAGGGCTTGCTCATCTGAACAGGGG
TGTATTTCATTCCAGGCCCTCAGTCTTTGGCAATGGCCACCCTGGTGTTGGCATATTGGCCCCACTGTAACTTTTGGGGGCTTCCCGGTC
TAGCCACACCCTCGGATGGAAAGACTTGACTGCATAAAGATGTCAGTTCTCCCTGAGTTGATTGATAGGCTTAATGGTCACCCTAAAAAC
ACCCACATATGCTTTTCGATGGAACCAGGTAAGTTGACGCTAAAGTTCTTATGGAAAAATACACACGCAATAGCTAGGAAAACACAGGGA
AAGAAGAGTTCTGAGCAGGGCCTAGTCTTAGCCAATATTAAAACATACTATGAAGCCTCTGATACTTAAACAGCATGGCGCTGGTACGTA
AATAGACCAATGCAGTTAGGTGGCTCTTTCCAAGACTCTGGGGAAAAAAGTAGTAAAAAGCTAAATGCAATCAATCAGCAATTGAAAGCT
AAGTGAGAGAGCCAGAGGGCCTCCTTGGTGGTAAAAGAGGGTTGCATTTCTTGCAGCCAGAAGGCAGAGAAAGTGAAGACCAAGTCCAGA
ACTGAATCCTAAGAAATGCAGGACTGCAAAGAAATTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTAATTTTTAAAAAGTTTT
TATTGAGATACAAGTCAATACCATAAAGCTCTCACCCTTCTAAAGTGTACAATTCAGTGGTGTGAGTATATTCATAAGATTTATACTTGG
TGTCTATTCATAAGACTTATATCCAGCATATTCATAACTAGAGCCATATCACAGATGCATTCATCATAATAATTCCAGACATTTTCATCA
CCCTAAAAGGAAACCCTGAAACCCATTAGCAGTCATTCCCCATTCCTCCAACCCATTCTCTCCCTAATCCCTAGAAACCACCAATCTGCT

>93265_93265_1_TPCN1-OAS3_TPCN1_chr12_113664769_ENST00000335509_OAS3_chr12_113405223_ENST00000228928_length(amino acids)=236AA_BP=69
MRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKSQLVSGSRPSSQVYVDLIHSYSNAGEYSTCFTELQRDFIISRPTK
LKSLIRLVKHWYQQCTKISKGRGSLPPQHGLELLTVYAWEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKDKTVGDFLKQQL

--------------------------------------------------------------
>93265_93265_2_TPCN1-OAS3_TPCN1_chr12_113664769_ENST00000541517_OAS3_chr12_113405223_ENST00000228928_length(transcript)=4181nt_BP=330nt
AGATGGAGTCTTGCTACATTGCCCAGGCTGGTCTTGAACTGCTAGGCTCAAGCAGTTCTCCCACCTTGACCTCCCAAAGCGCTGAGATTA
CAGAAGATGCCTCTAATGGAGGAGTTTCTGAGCAGCACCCCTGGCCCAGTGGCTTTGAAAGGGAGCTCAAACCAGAGACTATTTCAAGCC
CTGGATATCATATCCTGAGGGCCACAGGAGAAGAGAACATGGCTGTGAGTTTGGATGACGACGTGCCGCTCATCCTGACCTTGGATGAGG
GTGGCAGTGCCCCACTGGCTCCCTCCAACGGCCTGGGCCAAGAAGAGCTACCTAGCAAAAGCCAGCTGGTCTCTGGCTCCAGGCCCAGCT
CTCAAGTCTACGTCGACCTCATCCACAGCTACAGCAATGCGGGCGAGTACTCCACCTGCTTCACAGAGCTACAACGGGACTTCATCATCT
CTCGCCCTACCAAGCTGAAGAGCCTGATCCGGCTGGTGAAGCACTGGTACCAGCAGTGTACCAAGATCTCCAAGGGGAGAGGCTCCCTAC
CCCCACAGCACGGGCTGGAACTCCTGACTGTGTATGCCTGGGAGCAGGGCGGGAAGGACTCCCAGTTCAACATGGCTGAGGGCTTCCGCA
CGGTCCTGGAGCTGGTCACCCAGTACCGCCAGCTCTGTATCTACTGGACCATCAACTACAACGCCAAGGACAAGACTGTTGGAGACTTCC
TGAAACAGCAGCTTCAGAAGCCCAGGCCTATCATCCTGGATCCGGCTGACCCGACAGGCAACCTGGGCCACAATGCCCGCTGGGACCTGC
TGGCCAAGGAAGCTGCAGCCTGCACATCTGCCCTGTGCTGCATGGGACGGAATGGCATCCCCATCCAGCCATGGCCAGTGAAGGCTGCTG
TGTGAAGTTGAGAAAATCAGCGGTCCTACTGGATGAAGAGAAGATGGACACCAGCCCTCAGCATGAGGAAATTCAGGGTCCCCTACCAGA
TGAGAGAGATTGTGTACATGTGTGTGTGAGCACATGTGTGCATGTGTGTGCACACGTGTGCATGTGTGTGTTTTAGTGAATCTGCTCTCC
CAGCTCACACACTCCCCTGCCTCCCATGGCTTACACACTAGGATCCAGACTCCATGGTTTGACACCAGCCTGCGTTTGCAGCTTCTCTGT
CACTTCCATGACTCTATCCTCATACCACCACTGCTGCTTCCCACCCAGCTGAGAATGCCCCCTCCTCCCTGACTCCTCTCTGCCCATGCA
AATTAGCTCACATCTTTCCTCCTGCTGCAATCCATCCCTTCCTCCCATTGGCCTCTCCTTGCCAAATCTAAATAGTTTATATAGGGATGG
CAGAGAGTTCCCATCTCATCTGTCAGCCACAGTCATTTGGTACTGGCTACCTGGAGCCTTATCTTCTGAAGGGTTTTAAAGAATGGCCAA
TTAGCTGAGAAGAATTATCTAATCAATTAGTGATGTCTGCCATGGATGCAGTAGAGGAAAGTGGTGGTACAAGTGCCATGATTGATTAGC
AATGTCTGCACTGGATACGGAAAAAAGAAGGTGCTTGCAGGTTTACAGTGTATATGTGGGCTATTGAAGAGCCCTCTGAGCTCGGTTGCT
AGCAGGAGAGCATGCCCATATTGGCTTACTTTGTCTGCCACAGACACAGACAGAGGGAGTTGGGACATGCATGCTATGGGGACCCTCTTG
TTGGACACCTAATTGGATGCCTCTTCATGAGAGGCCTCCTTTTCTTCACCTTTTATGCTGCACTCCTCCCCTAGTTTACACATCTTGATG
CTGTGGCTCAGTTTGCCTTCCTGAATTTTTATTGGGTCCCTGTTTTCTCTCCTAACATGCTGAGATTCTGCATCCCCACAGCCTAAACTG
AGCCAGTGGCCAAACAACCGTGCTCAGCCTGTTTCTCTCTGCCCTCTAGAGCAAGGCCCACCAGGTCCATCCAGGAGGCTCTCCTGACCT
CAAGTCCAACAACAGTGTCCACACTAGTCAAGGTTCAGCCCAGAAAACAGAAAGCACTCTAGGAATCTTAGGCAGAAAGGGATTTTATCT
AAATCACTGGAAAGGCTGGAGGAGCAGAAGGCAGAGGCCACCACTGGACTATTGGTTTCAATATTAGACCACTGTAGCCGAATCAGAGGC
CAGAGAGCAGCCACTGCTACTGCTAATGCCACCACTACCCCTGCCATCACTGCCCCACATGGACAAAACTGGAGTCGAGACCTAGGTTAG
ATTCCTGCAACCACAAACATCCATCAGGGATGGCCAGCTGCCAGAGCTGCGGGAAGACGGATCCCACCTCCCTTTCTTAGCAGAATCTAA
ATTACAGCCAGACCTCTGGCTGCAGAGGAGTCTGAGACATGTATGATTGAATGGGTGCCAAGTGCCAGGGGGCGGAGTCCCCAGCAGATG
CATCCTGGCCATCTGTTGCGTGGATGAGGGAGTGGGTCTATCTCAGAGGAAGGAACAGGAAACAAAGAAAGGAAGCCACTGAACATCCCT
TCTCTGCTCCACAGGAGTGCCTTAGACAGCCTGACTCTCCACAAACCACTGTTAAAACTTACCTGCTAGGAATGCTAGATTGAATGGGAT
GGGAAGAGCCTTCCCTCATTATTGTCATTCTTGGAGAGAGGTGAGCAACCAAGGGAAGCTCCTCTGATTCACCTAGAACCTGTTCTCTGC
CGTCTTTGGCTCAGCCTACAGAGACTAGAGTAGGTGAAGGGACAGAGGACAGGGCTTCTAATACCTGTGCCATATTGACAGCCTCCATCC
CTGTCCCCCATCTTGGTGCTGAACCAACGCTAAGGGCACCTTCTTAGACTCACCTCATCGATACTGCCTGGTAATCCAAAGCTAGAACTC
TCAGGACCCCAAACTCCACCTCTTGGATTGGCCCTGGCTGCTGCCACACACATATCCAAGAGCTCAGGGCCAGTTCTGGTGGGCAGCAGA
GACCTGCTCTGCCAAGTTGTCCAGCAGCAGAGTGGCCCTGGCCTGGGCATCACAAGCCAGTGATGCTCCTGGGAAGACCAGGTGGCAGGT
CGCAGTTGGGTACCTTCCATTCCCACCACACAGACTCTGGGCCTCCCCGCAAAATGGCTCCAGAATTAGAGTAATTATGAGATGGTGGGA
ACCAGAGCAACTCAGGTGCATGATACAAGGAGAGGTTGTCATCTGGGTAGGGCAGAGAGGAGGGCTTGCTCATCTGAACAGGGGTGTATT
TCATTCCAGGCCCTCAGTCTTTGGCAATGGCCACCCTGGTGTTGGCATATTGGCCCCACTGTAACTTTTGGGGGCTTCCCGGTCTAGCCA
CACCCTCGGATGGAAAGACTTGACTGCATAAAGATGTCAGTTCTCCCTGAGTTGATTGATAGGCTTAATGGTCACCCTAAAAACACCCAC
ATATGCTTTTCGATGGAACCAGGTAAGTTGACGCTAAAGTTCTTATGGAAAAATACACACGCAATAGCTAGGAAAACACAGGGAAAGAAG
AGTTCTGAGCAGGGCCTAGTCTTAGCCAATATTAAAACATACTATGAAGCCTCTGATACTTAAACAGCATGGCGCTGGTACGTAAATAGA
CCAATGCAGTTAGGTGGCTCTTTCCAAGACTCTGGGGAAAAAAGTAGTAAAAAGCTAAATGCAATCAATCAGCAATTGAAAGCTAAGTGA
GAGAGCCAGAGGGCCTCCTTGGTGGTAAAAGAGGGTTGCATTTCTTGCAGCCAGAAGGCAGAGAAAGTGAAGACCAAGTCCAGAACTGAA
TCCTAAGAAATGCAGGACTGCAAAGAAATTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTAATTTTTAAAAAGTTTTTATTGA
GATACAAGTCAATACCATAAAGCTCTCACCCTTCTAAAGTGTACAATTCAGTGGTGTGAGTATATTCATAAGATTTATACTTGGTGTCTA
TTCATAAGACTTATATCCAGCATATTCATAACTAGAGCCATATCACAGATGCATTCATCATAATAATTCCAGACATTTTCATCACCCTAA
AAGGAAACCCTGAAACCCATTAGCAGTCATTCCCCATTCCTCCAACCCATTCTCTCCCTAATCCCTAGAAACCACCAATCTGCTGTGTAT

>93265_93265_2_TPCN1-OAS3_TPCN1_chr12_113664769_ENST00000541517_OAS3_chr12_113405223_ENST00000228928_length(amino acids)=300AA_BP=7
MESCYIAQAGLELLGSSSSPTLTSQSAEITEDASNGGVSEQHPWPSGFERELKPETISSPGYHILRATGEENMAVSLDDDVPLILTLDEG
GSAPLAPSNGLGQEELPSKSQLVSGSRPSSQVYVDLIHSYSNAGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKISKGRGSLP
PQHGLELLTVYAWEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKDKTVGDFLKQQLQKPRPIILDPADPTGNLGHNARWDLL

--------------------------------------------------------------
>93265_93265_3_TPCN1-OAS3_TPCN1_chr12_113664769_ENST00000550785_OAS3_chr12_113405223_ENST00000228928_length(transcript)=4348nt_BP=497nt
AGGAGAGCTGGCGCAGCTGCCCTGGTGGCAGTGGCTGAAGTGGCGGCGGCTTCGGCGGCTGCGGCGGCTGCAACAGCTTCGGGCTCGGGG
TTTTGGCGGCGGCGCCGGCGGGCTAGGCTGCGCGGTGCGGACCCCGGCGCGCGGTCCGGGTTGCTGGGGCGGCGCGTAGATGGAGTCTTG
CTACATTGCCCAGGCTGGTCTTGAACTGCTAGGCTCAAGCAGTTCTCCCACCTTGACCTCCCAAAGCGCTGAGATTACAGAAGATGCCTC
TAATGGAGGAGTTTCTGAGCAGCACCCCTGGCCCAGTGGCTTTGAAAGGGAGCTCAAACCAGAGACTATTTCAAGCCCTGGATATCATAT
CCTGAGGGCCACAGGAGAAGAGAACATGGCTGTGAGTTTGGATGACGACGTGCCGCTCATCCTGACCTTGGATGAGGGTGGCAGTGCCCC
ACTGGCTCCCTCCAACGGCCTGGGCCAAGAAGAGCTACCTAGCAAAAGCCAGCTGGTCTCTGGCTCCAGGCCCAGCTCTCAAGTCTACGT
CGACCTCATCCACAGCTACAGCAATGCGGGCGAGTACTCCACCTGCTTCACAGAGCTACAACGGGACTTCATCATCTCTCGCCCTACCAA
GCTGAAGAGCCTGATCCGGCTGGTGAAGCACTGGTACCAGCAGTGTACCAAGATCTCCAAGGGGAGAGGCTCCCTACCCCCACAGCACGG
GCTGGAACTCCTGACTGTGTATGCCTGGGAGCAGGGCGGGAAGGACTCCCAGTTCAACATGGCTGAGGGCTTCCGCACGGTCCTGGAGCT
GGTCACCCAGTACCGCCAGCTCTGTATCTACTGGACCATCAACTACAACGCCAAGGACAAGACTGTTGGAGACTTCCTGAAACAGCAGCT
TCAGAAGCCCAGGCCTATCATCCTGGATCCGGCTGACCCGACAGGCAACCTGGGCCACAATGCCCGCTGGGACCTGCTGGCCAAGGAAGC
TGCAGCCTGCACATCTGCCCTGTGCTGCATGGGACGGAATGGCATCCCCATCCAGCCATGGCCAGTGAAGGCTGCTGTGTGAAGTTGAGA
AAATCAGCGGTCCTACTGGATGAAGAGAAGATGGACACCAGCCCTCAGCATGAGGAAATTCAGGGTCCCCTACCAGATGAGAGAGATTGT
GTACATGTGTGTGTGAGCACATGTGTGCATGTGTGTGCACACGTGTGCATGTGTGTGTTTTAGTGAATCTGCTCTCCCAGCTCACACACT
CCCCTGCCTCCCATGGCTTACACACTAGGATCCAGACTCCATGGTTTGACACCAGCCTGCGTTTGCAGCTTCTCTGTCACTTCCATGACT
CTATCCTCATACCACCACTGCTGCTTCCCACCCAGCTGAGAATGCCCCCTCCTCCCTGACTCCTCTCTGCCCATGCAAATTAGCTCACAT
CTTTCCTCCTGCTGCAATCCATCCCTTCCTCCCATTGGCCTCTCCTTGCCAAATCTAAATAGTTTATATAGGGATGGCAGAGAGTTCCCA
TCTCATCTGTCAGCCACAGTCATTTGGTACTGGCTACCTGGAGCCTTATCTTCTGAAGGGTTTTAAAGAATGGCCAATTAGCTGAGAAGA
ATTATCTAATCAATTAGTGATGTCTGCCATGGATGCAGTAGAGGAAAGTGGTGGTACAAGTGCCATGATTGATTAGCAATGTCTGCACTG
GATACGGAAAAAAGAAGGTGCTTGCAGGTTTACAGTGTATATGTGGGCTATTGAAGAGCCCTCTGAGCTCGGTTGCTAGCAGGAGAGCAT
GCCCATATTGGCTTACTTTGTCTGCCACAGACACAGACAGAGGGAGTTGGGACATGCATGCTATGGGGACCCTCTTGTTGGACACCTAAT
TGGATGCCTCTTCATGAGAGGCCTCCTTTTCTTCACCTTTTATGCTGCACTCCTCCCCTAGTTTACACATCTTGATGCTGTGGCTCAGTT
TGCCTTCCTGAATTTTTATTGGGTCCCTGTTTTCTCTCCTAACATGCTGAGATTCTGCATCCCCACAGCCTAAACTGAGCCAGTGGCCAA
ACAACCGTGCTCAGCCTGTTTCTCTCTGCCCTCTAGAGCAAGGCCCACCAGGTCCATCCAGGAGGCTCTCCTGACCTCAAGTCCAACAAC
AGTGTCCACACTAGTCAAGGTTCAGCCCAGAAAACAGAAAGCACTCTAGGAATCTTAGGCAGAAAGGGATTTTATCTAAATCACTGGAAA
GGCTGGAGGAGCAGAAGGCAGAGGCCACCACTGGACTATTGGTTTCAATATTAGACCACTGTAGCCGAATCAGAGGCCAGAGAGCAGCCA
CTGCTACTGCTAATGCCACCACTACCCCTGCCATCACTGCCCCACATGGACAAAACTGGAGTCGAGACCTAGGTTAGATTCCTGCAACCA
CAAACATCCATCAGGGATGGCCAGCTGCCAGAGCTGCGGGAAGACGGATCCCACCTCCCTTTCTTAGCAGAATCTAAATTACAGCCAGAC
CTCTGGCTGCAGAGGAGTCTGAGACATGTATGATTGAATGGGTGCCAAGTGCCAGGGGGCGGAGTCCCCAGCAGATGCATCCTGGCCATC
TGTTGCGTGGATGAGGGAGTGGGTCTATCTCAGAGGAAGGAACAGGAAACAAAGAAAGGAAGCCACTGAACATCCCTTCTCTGCTCCACA
GGAGTGCCTTAGACAGCCTGACTCTCCACAAACCACTGTTAAAACTTACCTGCTAGGAATGCTAGATTGAATGGGATGGGAAGAGCCTTC
CCTCATTATTGTCATTCTTGGAGAGAGGTGAGCAACCAAGGGAAGCTCCTCTGATTCACCTAGAACCTGTTCTCTGCCGTCTTTGGCTCA
GCCTACAGAGACTAGAGTAGGTGAAGGGACAGAGGACAGGGCTTCTAATACCTGTGCCATATTGACAGCCTCCATCCCTGTCCCCCATCT
TGGTGCTGAACCAACGCTAAGGGCACCTTCTTAGACTCACCTCATCGATACTGCCTGGTAATCCAAAGCTAGAACTCTCAGGACCCCAAA
CTCCACCTCTTGGATTGGCCCTGGCTGCTGCCACACACATATCCAAGAGCTCAGGGCCAGTTCTGGTGGGCAGCAGAGACCTGCTCTGCC
AAGTTGTCCAGCAGCAGAGTGGCCCTGGCCTGGGCATCACAAGCCAGTGATGCTCCTGGGAAGACCAGGTGGCAGGTCGCAGTTGGGTAC
CTTCCATTCCCACCACACAGACTCTGGGCCTCCCCGCAAAATGGCTCCAGAATTAGAGTAATTATGAGATGGTGGGAACCAGAGCAACTC
AGGTGCATGATACAAGGAGAGGTTGTCATCTGGGTAGGGCAGAGAGGAGGGCTTGCTCATCTGAACAGGGGTGTATTTCATTCCAGGCCC
TCAGTCTTTGGCAATGGCCACCCTGGTGTTGGCATATTGGCCCCACTGTAACTTTTGGGGGCTTCCCGGTCTAGCCACACCCTCGGATGG
AAAGACTTGACTGCATAAAGATGTCAGTTCTCCCTGAGTTGATTGATAGGCTTAATGGTCACCCTAAAAACACCCACATATGCTTTTCGA
TGGAACCAGGTAAGTTGACGCTAAAGTTCTTATGGAAAAATACACACGCAATAGCTAGGAAAACACAGGGAAAGAAGAGTTCTGAGCAGG
GCCTAGTCTTAGCCAATATTAAAACATACTATGAAGCCTCTGATACTTAAACAGCATGGCGCTGGTACGTAAATAGACCAATGCAGTTAG
GTGGCTCTTTCCAAGACTCTGGGGAAAAAAGTAGTAAAAAGCTAAATGCAATCAATCAGCAATTGAAAGCTAAGTGAGAGAGCCAGAGGG
CCTCCTTGGTGGTAAAAGAGGGTTGCATTTCTTGCAGCCAGAAGGCAGAGAAAGTGAAGACCAAGTCCAGAACTGAATCCTAAGAAATGC
AGGACTGCAAAGAAATTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTAATTTTTAAAAAGTTTTTATTGAGATACAAGTCAAT
ACCATAAAGCTCTCACCCTTCTAAAGTGTACAATTCAGTGGTGTGAGTATATTCATAAGATTTATACTTGGTGTCTATTCATAAGACTTA
TATCCAGCATATTCATAACTAGAGCCATATCACAGATGCATTCATCATAATAATTCCAGACATTTTCATCACCCTAAAAGGAAACCCTGA
AACCCATTAGCAGTCATTCCCCATTCCTCCAACCCATTCTCTCCCTAATCCCTAGAAACCACCAATCTGCTGTGTATTTCATCTATTGCC

>93265_93265_3_TPCN1-OAS3_TPCN1_chr12_113664769_ENST00000550785_OAS3_chr12_113405223_ENST00000228928_length(amino acids)=300AA_BP=7
MESCYIAQAGLELLGSSSSPTLTSQSAEITEDASNGGVSEQHPWPSGFERELKPETISSPGYHILRATGEENMAVSLDDDVPLILTLDEG
GSAPLAPSNGLGQEELPSKSQLVSGSRPSSQVYVDLIHSYSNAGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKISKGRGSLP
PQHGLELLTVYAWEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKDKTVGDFLKQQLQKPRPIILDPADPTGNLGHNARWDLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TPCN1-OAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneOAS3chr12:113664769chr12:113405223ENST00000228928111612_57896.33333333333341088.0dsRNA
TgeneOAS3chr12:113664769chr12:113405223ENST000002289281116186_200896.33333333333341088.0dsRNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TPCN1-OAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TPCN1-OAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource