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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TPD52-NECAB1 (FusionGDB2 ID:93303)

Fusion Gene Summary for TPD52-NECAB1

check button Fusion gene summary
Fusion gene informationFusion gene name: TPD52-NECAB1
Fusion gene ID: 93303
HgeneTgene
Gene symbol

TPD52

NECAB1

Gene ID

7163

64168

Gene nametumor protein D52N-terminal EF-hand calcium binding protein 1
SynonymsD52|N8L|PC-1|PrLZ|hD52EFCBP1|STIP-1
Cytomap

8q21.13

8q21.3

Type of geneprotein-codingprotein-coding
Descriptiontumor protein D52prostate and colon associated proteinprostate leucine zipperprotein N8N-terminal EF-hand calcium-binding protein 1EF-hand calcium-binding protein 1neuronal calcium binding proteinneuronal calcium-binding protein 1synaptotagmin interacting protein 1
Modification date2020031320200313
UniProtAcc.

Q8N987

Ensembl transtripts involved in fusion geneENST00000379096, ENST00000518937, 
ENST00000379097, ENST00000448733, 
ENST00000517427, ENST00000519303, 
ENST00000520527, ENST00000523395, 
ENST00000537855, 		ENST00000521954, 
ENST00000521366, ENST00000522820, 
ENST00000417640, 
Fusion gene scores* DoF score21 X 15 X 9=28356 X 3 X 4=72
# samples 306
** MAII scorelog2(30/2835*10)=-3.24031432933371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TPD52 [Title/Abstract] AND NECAB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTPD52(81083660)-NECAB1(91813919), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TPD52 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NECAB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A079-01ATPD52chr8

81083660

-NECAB1chr8

91813919

+


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Fusion Gene ORF analysis for TPD52-NECAB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000379096ENST00000521954TPD52chr8

81083660

-NECAB1chr8

91813919

+
5CDS-3UTRENST00000518937ENST00000521954TPD52chr8

81083660

-NECAB1chr8

91813919

+
5CDS-intronENST00000379096ENST00000521366TPD52chr8

81083660

-NECAB1chr8

91813919

+
5CDS-intronENST00000379096ENST00000522820TPD52chr8

81083660

-NECAB1chr8

91813919

+
5CDS-intronENST00000518937ENST00000521366TPD52chr8

81083660

-NECAB1chr8

91813919

+
5CDS-intronENST00000518937ENST00000522820TPD52chr8

81083660

-NECAB1chr8

91813919

+
In-frameENST00000379096ENST00000417640TPD52chr8

81083660

-NECAB1chr8

91813919

+
In-frameENST00000518937ENST00000417640TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-3CDSENST00000379097ENST00000417640TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-3CDSENST00000448733ENST00000417640TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-3CDSENST00000517427ENST00000417640TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-3CDSENST00000519303ENST00000417640TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-3CDSENST00000520527ENST00000417640TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-3CDSENST00000523395ENST00000417640TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-3CDSENST00000537855ENST00000417640TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-3UTRENST00000379097ENST00000521954TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-3UTRENST00000448733ENST00000521954TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-3UTRENST00000517427ENST00000521954TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-3UTRENST00000519303ENST00000521954TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-3UTRENST00000520527ENST00000521954TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-3UTRENST00000523395ENST00000521954TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-3UTRENST00000537855ENST00000521954TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-intronENST00000379097ENST00000521366TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-intronENST00000379097ENST00000522820TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-intronENST00000448733ENST00000521366TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-intronENST00000448733ENST00000522820TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-intronENST00000517427ENST00000521366TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-intronENST00000517427ENST00000522820TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-intronENST00000519303ENST00000521366TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-intronENST00000519303ENST00000522820TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-intronENST00000520527ENST00000521366TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-intronENST00000520527ENST00000522820TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-intronENST00000523395ENST00000521366TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-intronENST00000523395ENST00000522820TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-intronENST00000537855ENST00000521366TPD52chr8

81083660

-NECAB1chr8

91813919

+
intron-intronENST00000537855ENST00000522820TPD52chr8

81083660

-NECAB1chr8

91813919

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379096TPD52chr881083660-ENST00000417640NECAB1chr891813919+4987134321090352
ENST00000518937TPD52chr881083660-ENST00000417640NECAB1chr891813919+50882351331191352

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379096ENST00000417640TPD52chr881083660-NECAB1chr891813919+0.001205380.99879456
ENST00000518937ENST00000417640TPD52chr881083660-NECAB1chr891813919+0.0011803910.99881953

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Fusion Genomic Features for TPD52-NECAB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TPD52chr881083659-NECAB1chr891813918+6.58E-050.9999342
TPD52chr881083659-NECAB1chr891813918+6.58E-050.9999342

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TPD52-NECAB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:81083660/chr8:91813919)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NECAB1

Q8N987

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNECAB1chr8:81083660chr8:91813919ENST0000041764001339_5033352.0Calcium binding1
TgeneNECAB1chr8:81083660chr8:91813919ENST000005213660439_500101.0Calcium binding1
TgeneNECAB1chr8:81083660chr8:91813919ENST000005228200539_500101.0Calcium binding1
TgeneNECAB1chr8:81083660chr8:91813919ENST00000417640013135_16333352.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:81083660chr8:91813919ENST00000417640013209_27533352.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:81083660chr8:91813919ENST0000052136604135_1630101.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:81083660chr8:91813919ENST0000052136604209_2750101.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:81083660chr8:91813919ENST0000052282005135_1630101.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:81083660chr8:91813919ENST0000052282005209_2750101.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:81083660chr8:91813919ENST00000417640013252_34033352.0DomainNote=ABM
TgeneNECAB1chr8:81083660chr8:91813919ENST0000041764001360_9533352.0DomainEF-hand 2
TgeneNECAB1chr8:81083660chr8:91813919ENST0000052136604252_3400101.0DomainNote=ABM
TgeneNECAB1chr8:81083660chr8:91813919ENST000005213660426_610101.0DomainEF-hand 1
TgeneNECAB1chr8:81083660chr8:91813919ENST000005213660460_950101.0DomainEF-hand 2
TgeneNECAB1chr8:81083660chr8:91813919ENST0000052282005252_3400101.0DomainNote=ABM
TgeneNECAB1chr8:81083660chr8:91813919ENST000005228200526_610101.0DomainEF-hand 1
TgeneNECAB1chr8:81083660chr8:91813919ENST000005228200560_950101.0DomainEF-hand 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTPD52chr8:81083660chr8:91813919ENST00000379096-1662_1146185.0Coiled coilOntology_term=ECO:0000255
HgeneTPD52chr8:81083660chr8:91813919ENST00000379097-1662_1140225.0Coiled coilOntology_term=ECO:0000255
HgeneTPD52chr8:81083660chr8:91813919ENST00000448733-1762_1140239.0Coiled coilOntology_term=ECO:0000255
HgeneTPD52chr8:81083660chr8:91813919ENST00000517427-1762_1140234.0Coiled coilOntology_term=ECO:0000255
HgeneTPD52chr8:81083660chr8:91813919ENST00000518937-1862_1146208.0Coiled coilOntology_term=ECO:0000255
HgeneTPD52chr8:81083660chr8:91813919ENST00000520527-1862_1140248.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:81083660chr8:91813919ENST0000041764001326_6133352.0DomainEF-hand 1


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Fusion Gene Sequence for TPD52-NECAB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93303_93303_1_TPD52-NECAB1_TPD52_chr8_81083660_ENST00000379096_NECAB1_chr8_91813919_ENST00000417640_length(transcript)=4987nt_BP=134nt
GCGGGAGTCGCCGGCGGAGGCGAGGAGGAGCTCTGCGCGGCGCGGCGGGCGATCCGAGCCGGGACGGGCTGCAGGCGGGGGTGCTGCAGA
GGACACGAGGCGGCGGGCTGGAGACATGGACCGCGGCGAGCAAGATACTGAGGAGAGCAGACAAAAATGATGATGGAAAATTATCCTTTG
AAGAATTCAAAGCATATTTTGCAGATGGTGTTCTCAGTGGAGAAGAATTACACGAGCTTTTCCATACCATTGATACACATAATACTAATA
ATCTTGACACAGAAGAGCTATGTGAATATTTTTCTCAGCACTTGGGCGAGTATGAGAATGTACTAGCAGCACTTGAAGACCTGAATCTTT
CCATCCTGAAGGCAATGGGCAAAACAAAGAAAGACTACCAAGAAGCCTCCAATTTGGAACAATTCGTAACTAGATTTTTATTGAAGGAAA
CCCTGAATCAGCTGCAGTCTCTCCAGAATTCCCTGGAATGTGCCATGGAAACTACTGAGGAGCAAACCCGTCAAGAAAGGCAAGGGCCAG
CCAAGCCAGAAGTCCTGTCGATTCAATGGCCTGGAAAACGATCAAGCCGCCGAGTCCAGAGACACAACAGCTTCTCCCCAAACAGCCCTC
AGTTTAATGTCAGCGGTCCAGGCTTATTAGAAGAAGACAACCAGTGGATGACCCAGATAAATAGACTCCAGAAATTAATTGATAGACTGG
AAAAGAAGGATCTCAAACTCGAACCACCAGAAGAAGAAATTATTGAAGGGAATACTAAATCTCACATCATGCTTGTGCAGCGGCAGATGT
CTGTGATAGAAGAGGACCTGGAAGAATTCCAGCTCGCTCTGAAACACTACGTGGAGAGTGCTTCCTCCCAAAGTGGATGCTTGCGTATTT
CTATACAGAAGCTTTCAAATGAATCTCGCTACATGATCTATGAGTTCTGGGAGAATAGTAGTGTATGGAATAGCCACCTTCAGACAAATT
ATAGCAAGACATTCCAAAGAAGTAATGTGGATTTCTTGGAAACTCCAGAACTCACATCTACAATGCTAGTTCCTGCTTCGTGGTGGATCC
TGAACAACTAGATGTTCCTAGACATTTTCTTTATGGTTCCAAGTGCAAAACAGGTGTTCTTATCTAAAACGTCAATTAGAAAATTATCTG
CGGTTGTTAATCTACTGTATATTTTTGTTTGGTATATTTACTAAGTGCACTCTTTCAAAACTTATTCTATAACTTTATCAATTCATGTGA
ATTTTAGCTCAATTTTCAAAGTTCACTAATATTCTCAATATTTAATGCTAAATGCTTTGCTACATTGTAACTCACCTAAAACCTTTTAGT
GACAAAATCCTAATATGTGGAAAAAAGCATATGCATAAAGGAATAATATTGTGAAAATGAATCTGTTATGATAAAGAAAAAATAAAGTGG
AAACTTTTAGAGTATTACTTCATAGGGCAGATTTTGTAAACTGTCGTATACTGTAAAGGGTTAAATCAGCGTTTTGTGATTTTTAAGTAA
CTGTGAGTGAAGTTTATTCTTCAACAATGTCTACTCCATCCCCAACCCAACTCACAGCCCTATGACTACTATCTTTGCATTAGTTAAAAA
GTTAGTATATAGGCATCAAACAACCTTGGCTGTAACCTATAGAATCTCTATCCACGTATCAGGTTATAGACTGGTTTTTCAAAAGTGAAC
AATCCTGTGATAAGTTGGAGTACCATTTAGTAATACAGCAACATTGTGTCATTTATTAGCATCATAATTCTTTGTTATGTAAGTTAAATA
TATCAAGAAAGAAGAGACTGTTTGGAAAAATGTGGTTCAAGTTTTATGCTATATAGTTTTGGTATGCGATACAGACAGCTAACTTTTCTT
ATGAAAAATACATATTTGCATGTAAACAATGATTTCAAAATACTTGAAAAATAAAATTTTAACCCAAATGAATAACTAAGAAATATAAAA
CAAGCACAAAATCTTAGGGAAGTCATAAAATAGTAGTGAAAGTATTAGACAGAAGACATCTGTTTTCGAATTTCAACACTAGAATGACTA
AAACTATCTACCTATAGAACTATCTGTAGATAGTATACTATCTACACTCTGCTCAACAAGCTCAGAAATTAAATATTTTTAATAATAAAA
ATCTGTTCTGGTTATAAACCTTGCTAATGAAAATACAATACATATAAAAATGTATAGCCATGTTATTTTCTAGTATAAATTCCTTTGAAA
CTATAAGTCTTTGAGGAAAATTATAAGGTAAAATTTTCCTGTTTTTCCCCCTTTGAAAAACTCAGGAAAAAAGGAAGATTGAACTAATAA
AATTTTATTTCTTAAATATAAATTTGACCTAAAATATTTTCTCAAACTAATTCATGAAACAGCAACTTTTACCAATACCTTTGTATACTC
TCAGTTCTCATTCAGTATAAATAAAATTTTAAAATCCTTTCATAGTTCTATTAGAAATAAGTAGTAAATTTTGATATATTGTACATACAC
ACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGTGTGCCTCTGGTCAACTCTAAGGATGACAGACACTGTGTAA
CAACACCTGGGTCAACTCTTTTAATTTATATACAAAGCAAAGAACAACATTAATGGAGATGCACAATGATTATTCAAACAAGCTATATAT
ATGTACAAAGGCAAACAGACACATAACAGTCTCTGCAGACTGATTGTATATAGTAAGAAAAGATCAAAAGACTTTAAAACCTAAATGACT
TTTGACATACAAACTCTTCTTGAGAATGTTTGTTGTAAATGGTTTCAAAAATACAAATTATAGCCAATCAAAACATTGCTTTGGTTGGTG
CATTTAAGTATCCAACTCAAAAAGCATATCAAATATTTTGGGTACTAGGCAGTTTCCAAAGTAGCATGGTAGTATTACTTGTTAAAAGGG
TTCTGTTTTCATTAACAGTACTAAGTGGAAGGGATCTGCAGATTCCAAACTGGAATAAGCTCTATCATATTCTGAAACAAGAATTAGAAT
GACTTGAGAACGGGCAAATAACAAAGCAAACCAATATAATTATATGGTCATTCTGACCCCAGCTCTTATACAAATTATACATGTATTTTT
GTGTATGTTTGTGAGAGTTGTATGTATGTGAATGTGTGTGAGTGTGTATTCACATACACATATATACTGGAACCTATAGTAGAAAAGGAA
ACTAGTAGGGCCAAAAAAAAAAAGAAAAAGAAAAAGAAAAAAGAAAAAAAAAGAAAAAACTGGGACCTAAGTATAAATATCTCATCCTAA
AGTAAACAATAAGTTTATAGTTAACGAAGATTTTTTTCTATTTAAAACCCCATTTTCCTAAAGAACAAAGTAGTAAAATAAAAAAAAATT
TAAAAAATTAAAAAATAAAAAAAAGAGGTCACTAAAAGACCAAGATGGGAAACGTAACATGGAATACAAGCTTGAATCTGGGAAACAAGC
TCAAAAAACAGTGAAAAAAAAAGTACTGGTTTAGGAGTTCAAAATTCAGTGAAACAAACTTTTTGCCAATAGACCTAGGGATCTAAGAAA
TAGAATTAGGGAGAGTTTACACTTACTTACCTATATATCAGCAGATTTTTCTGGAAGAAACCCTTTTTTTTTTTTTTTTTAAACAGTAAC
ATCCAGAGTGACAAATTGCAGGAGATTTAATGTATAAAATTTCTAGGAATTAAAAGCTTAAACCCAAAAATTGTTCATCCATATATAAGA
AATTATCGAATTAAAACTTAATGTATGTCAATTATTTTCAAATGTCTAAATTCCTTTGGAAATAAAAATATCAGTTTTACTTTGAAATTG
CTCAACTTCTGCTATTCATATGGTCTGATTAGTGACATAAGTAGCAGCCGTTTTTCAACTTCAGTTTCATTCACTACCATTGTTTCCAAA
TTATCAATCTCTGCTAGTAATTATGAATTTAAGACCATATTATTATCAAAAACCTAGAGACCAATCATATATCTGAAAAGAAATACCCAT
TAAAAATTCTGCCTCCTGTTTATTGAGAACTATGCATTGAACATTCTGAATCATTCTAAGCCTCTGGAGAGACTGTAATGATCCATTCAT
GAGCTGGTATGAAATCAGTGGGAAGCAGAACAACAGAAGGAACTTTAAAAGCAACAAGCAATTATGTACCATATATACACTGTAGCAAAT
ATTTTATATTTGAGAGTCTTTACAGCTTACATTTCCATTCCATTATTACAAGTGATGAAAAACAAAAAATTGCAAGTAGTATGCAAATTA
TAAATATACAGTCTTCCCACTTCACTAACCAAATTCCTACTTTCCAGTGTTACTTCCCAATTTATGCAGGAAACCTCCTGCAAAGCTGAA
ACTGATTAGAAAATTCTTTATATTTTAAAATAGCTCTTTCTCATTTTTAGAGAAGTCAAATAGCCAACCATCAAAATTAAGAATAAATTG
AATTGTCACAGTCCATTACAGTTATTGTTGCTAGATCCACCTCATTTGCAGATGTCCAAACTTAAATTCATCTGTTCTTAAAATGCTACT
TAAAACTTTGGTTGTTTTCCTGTAATATAAAAGAAAAAGTTAATTTATCAATTGATTGAATACAGTTTTTACTAATTAGTTTATCAAACC
AAATACTGTGAACGTACCAGGTGTTTACAGATTTAAATGCATGTTACCATAGAAACTATTAAAGTAACTAGAACTGTCAAATAACAAAAC
GGCTCATGTTTTTAAAATATATGTAACTCATTTTAAAATATATTAAATTGTATTCCAAACCTGTTCTTCTGTTTCTGTGGCACCTAGGTT
TAAAATATGTATTAATGTGTAAATCACAAGTAAAATGAATTCTAATGTACAAGTTTGTTTTAAAAAGTGTATGTCAAGCTTTTATTTACA

>93303_93303_1_TPD52-NECAB1_TPD52_chr8_81083660_ENST00000379096_NECAB1_chr8_91813919_ENST00000417640_length(amino acids)=352AA_BP=34
MRGAAGDPSRDGLQAGVLQRTRGGGLETWTAASKILRRADKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTHNTNNLDTEELCEYF
SQHLGEYENVLAALEDLNLSILKAMGKTKKDYQEASNLEQFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPAKPEVLSIQWP
GKRSSRRVQRHNSFSPNSPQFNVSGPGLLEEDNQWMTQINRLQKLIDRLEKKDLKLEPPEEEIIEGNTKSHIMLVQRQMSVIEEDLEEFQ

--------------------------------------------------------------
>93303_93303_2_TPD52-NECAB1_TPD52_chr8_81083660_ENST00000518937_NECAB1_chr8_91813919_ENST00000417640_length(transcript)=5088nt_BP=235nt
AGGTCGACCGGGTCAGGTGGTTGGGTGACGCCCCAGGAAAGCGCTCCAGGCCGAGGGCGGGCGGCGCCGCCGCGCCCGACGCCTCTGGGG
GTGGGGACTTCGCGGGAGTCGCCGGCGGAGGCGAGGAGGAGCTCTGCGCGGCGCGGCGGGCGATCCGAGCCGGGACGGGCTGCAGGCGGG
GGTGCTGCAGAGGACACGAGGCGGCGGGCTGGAGACATGGACCGCGGCGAGCAAGATACTGAGGAGAGCAGACAAAAATGATGATGGAAA
ATTATCCTTTGAAGAATTCAAAGCATATTTTGCAGATGGTGTTCTCAGTGGAGAAGAATTACACGAGCTTTTCCATACCATTGATACACA
TAATACTAATAATCTTGACACAGAAGAGCTATGTGAATATTTTTCTCAGCACTTGGGCGAGTATGAGAATGTACTAGCAGCACTTGAAGA
CCTGAATCTTTCCATCCTGAAGGCAATGGGCAAAACAAAGAAAGACTACCAAGAAGCCTCCAATTTGGAACAATTCGTAACTAGATTTTT
ATTGAAGGAAACCCTGAATCAGCTGCAGTCTCTCCAGAATTCCCTGGAATGTGCCATGGAAACTACTGAGGAGCAAACCCGTCAAGAAAG
GCAAGGGCCAGCCAAGCCAGAAGTCCTGTCGATTCAATGGCCTGGAAAACGATCAAGCCGCCGAGTCCAGAGACACAACAGCTTCTCCCC
AAACAGCCCTCAGTTTAATGTCAGCGGTCCAGGCTTATTAGAAGAAGACAACCAGTGGATGACCCAGATAAATAGACTCCAGAAATTAAT
TGATAGACTGGAAAAGAAGGATCTCAAACTCGAACCACCAGAAGAAGAAATTATTGAAGGGAATACTAAATCTCACATCATGCTTGTGCA
GCGGCAGATGTCTGTGATAGAAGAGGACCTGGAAGAATTCCAGCTCGCTCTGAAACACTACGTGGAGAGTGCTTCCTCCCAAAGTGGATG
CTTGCGTATTTCTATACAGAAGCTTTCAAATGAATCTCGCTACATGATCTATGAGTTCTGGGAGAATAGTAGTGTATGGAATAGCCACCT
TCAGACAAATTATAGCAAGACATTCCAAAGAAGTAATGTGGATTTCTTGGAAACTCCAGAACTCACATCTACAATGCTAGTTCCTGCTTC
GTGGTGGATCCTGAACAACTAGATGTTCCTAGACATTTTCTTTATGGTTCCAAGTGCAAAACAGGTGTTCTTATCTAAAACGTCAATTAG
AAAATTATCTGCGGTTGTTAATCTACTGTATATTTTTGTTTGGTATATTTACTAAGTGCACTCTTTCAAAACTTATTCTATAACTTTATC
AATTCATGTGAATTTTAGCTCAATTTTCAAAGTTCACTAATATTCTCAATATTTAATGCTAAATGCTTTGCTACATTGTAACTCACCTAA
AACCTTTTAGTGACAAAATCCTAATATGTGGAAAAAAGCATATGCATAAAGGAATAATATTGTGAAAATGAATCTGTTATGATAAAGAAA
AAATAAAGTGGAAACTTTTAGAGTATTACTTCATAGGGCAGATTTTGTAAACTGTCGTATACTGTAAAGGGTTAAATCAGCGTTTTGTGA
TTTTTAAGTAACTGTGAGTGAAGTTTATTCTTCAACAATGTCTACTCCATCCCCAACCCAACTCACAGCCCTATGACTACTATCTTTGCA
TTAGTTAAAAAGTTAGTATATAGGCATCAAACAACCTTGGCTGTAACCTATAGAATCTCTATCCACGTATCAGGTTATAGACTGGTTTTT
CAAAAGTGAACAATCCTGTGATAAGTTGGAGTACCATTTAGTAATACAGCAACATTGTGTCATTTATTAGCATCATAATTCTTTGTTATG
TAAGTTAAATATATCAAGAAAGAAGAGACTGTTTGGAAAAATGTGGTTCAAGTTTTATGCTATATAGTTTTGGTATGCGATACAGACAGC
TAACTTTTCTTATGAAAAATACATATTTGCATGTAAACAATGATTTCAAAATACTTGAAAAATAAAATTTTAACCCAAATGAATAACTAA
GAAATATAAAACAAGCACAAAATCTTAGGGAAGTCATAAAATAGTAGTGAAAGTATTAGACAGAAGACATCTGTTTTCGAATTTCAACAC
TAGAATGACTAAAACTATCTACCTATAGAACTATCTGTAGATAGTATACTATCTACACTCTGCTCAACAAGCTCAGAAATTAAATATTTT
TAATAATAAAAATCTGTTCTGGTTATAAACCTTGCTAATGAAAATACAATACATATAAAAATGTATAGCCATGTTATTTTCTAGTATAAA
TTCCTTTGAAACTATAAGTCTTTGAGGAAAATTATAAGGTAAAATTTTCCTGTTTTTCCCCCTTTGAAAAACTCAGGAAAAAAGGAAGAT
TGAACTAATAAAATTTTATTTCTTAAATATAAATTTGACCTAAAATATTTTCTCAAACTAATTCATGAAACAGCAACTTTTACCAATACC
TTTGTATACTCTCAGTTCTCATTCAGTATAAATAAAATTTTAAAATCCTTTCATAGTTCTATTAGAAATAAGTAGTAAATTTTGATATAT
TGTACATACACACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGTGTGCCTCTGGTCAACTCTAAGGATGACAG
ACACTGTGTAACAACACCTGGGTCAACTCTTTTAATTTATATACAAAGCAAAGAACAACATTAATGGAGATGCACAATGATTATTCAAAC
AAGCTATATATATGTACAAAGGCAAACAGACACATAACAGTCTCTGCAGACTGATTGTATATAGTAAGAAAAGATCAAAAGACTTTAAAA
CCTAAATGACTTTTGACATACAAACTCTTCTTGAGAATGTTTGTTGTAAATGGTTTCAAAAATACAAATTATAGCCAATCAAAACATTGC
TTTGGTTGGTGCATTTAAGTATCCAACTCAAAAAGCATATCAAATATTTTGGGTACTAGGCAGTTTCCAAAGTAGCATGGTAGTATTACT
TGTTAAAAGGGTTCTGTTTTCATTAACAGTACTAAGTGGAAGGGATCTGCAGATTCCAAACTGGAATAAGCTCTATCATATTCTGAAACA
AGAATTAGAATGACTTGAGAACGGGCAAATAACAAAGCAAACCAATATAATTATATGGTCATTCTGACCCCAGCTCTTATACAAATTATA
CATGTATTTTTGTGTATGTTTGTGAGAGTTGTATGTATGTGAATGTGTGTGAGTGTGTATTCACATACACATATATACTGGAACCTATAG
TAGAAAAGGAAACTAGTAGGGCCAAAAAAAAAAAGAAAAAGAAAAAGAAAAAAGAAAAAAAAAGAAAAAACTGGGACCTAAGTATAAATA
TCTCATCCTAAAGTAAACAATAAGTTTATAGTTAACGAAGATTTTTTTCTATTTAAAACCCCATTTTCCTAAAGAACAAAGTAGTAAAAT
AAAAAAAAATTTAAAAAATTAAAAAATAAAAAAAAGAGGTCACTAAAAGACCAAGATGGGAAACGTAACATGGAATACAAGCTTGAATCT
GGGAAACAAGCTCAAAAAACAGTGAAAAAAAAAGTACTGGTTTAGGAGTTCAAAATTCAGTGAAACAAACTTTTTGCCAATAGACCTAGG
GATCTAAGAAATAGAATTAGGGAGAGTTTACACTTACTTACCTATATATCAGCAGATTTTTCTGGAAGAAACCCTTTTTTTTTTTTTTTT
TAAACAGTAACATCCAGAGTGACAAATTGCAGGAGATTTAATGTATAAAATTTCTAGGAATTAAAAGCTTAAACCCAAAAATTGTTCATC
CATATATAAGAAATTATCGAATTAAAACTTAATGTATGTCAATTATTTTCAAATGTCTAAATTCCTTTGGAAATAAAAATATCAGTTTTA
CTTTGAAATTGCTCAACTTCTGCTATTCATATGGTCTGATTAGTGACATAAGTAGCAGCCGTTTTTCAACTTCAGTTTCATTCACTACCA
TTGTTTCCAAATTATCAATCTCTGCTAGTAATTATGAATTTAAGACCATATTATTATCAAAAACCTAGAGACCAATCATATATCTGAAAA
GAAATACCCATTAAAAATTCTGCCTCCTGTTTATTGAGAACTATGCATTGAACATTCTGAATCATTCTAAGCCTCTGGAGAGACTGTAAT
GATCCATTCATGAGCTGGTATGAAATCAGTGGGAAGCAGAACAACAGAAGGAACTTTAAAAGCAACAAGCAATTATGTACCATATATACA
CTGTAGCAAATATTTTATATTTGAGAGTCTTTACAGCTTACATTTCCATTCCATTATTACAAGTGATGAAAAACAAAAAATTGCAAGTAG
TATGCAAATTATAAATATACAGTCTTCCCACTTCACTAACCAAATTCCTACTTTCCAGTGTTACTTCCCAATTTATGCAGGAAACCTCCT
GCAAAGCTGAAACTGATTAGAAAATTCTTTATATTTTAAAATAGCTCTTTCTCATTTTTAGAGAAGTCAAATAGCCAACCATCAAAATTA
AGAATAAATTGAATTGTCACAGTCCATTACAGTTATTGTTGCTAGATCCACCTCATTTGCAGATGTCCAAACTTAAATTCATCTGTTCTT
AAAATGCTACTTAAAACTTTGGTTGTTTTCCTGTAATATAAAAGAAAAAGTTAATTTATCAATTGATTGAATACAGTTTTTACTAATTAG
TTTATCAAACCAAATACTGTGAACGTACCAGGTGTTTACAGATTTAAATGCATGTTACCATAGAAACTATTAAAGTAACTAGAACTGTCA
AATAACAAAACGGCTCATGTTTTTAAAATATATGTAACTCATTTTAAAATATATTAAATTGTATTCCAAACCTGTTCTTCTGTTTCTGTG
GCACCTAGGTTTAAAATATGTATTAATGTGTAAATCACAAGTAAAATGAATTCTAATGTACAAGTTTGTTTTAAAAAGTGTATGTCAAGC

>93303_93303_2_TPD52-NECAB1_TPD52_chr8_81083660_ENST00000518937_NECAB1_chr8_91813919_ENST00000417640_length(amino acids)=352AA_BP=34
MRGAAGDPSRDGLQAGVLQRTRGGGLETWTAASKILRRADKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTHNTNNLDTEELCEYF
SQHLGEYENVLAALEDLNLSILKAMGKTKKDYQEASNLEQFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPAKPEVLSIQWP
GKRSSRRVQRHNSFSPNSPQFNVSGPGLLEEDNQWMTQINRLQKLIDRLEKKDLKLEPPEEEIIEGNTKSHIMLVQRQMSVIEEDLEEFQ

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Fusion Gene PPI Analysis for TPD52-NECAB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TPD52-NECAB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TPD52-NECAB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource