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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TPGS2-DERA (FusionGDB2 ID:93316)

Fusion Gene Summary for TPGS2-DERA

check button Fusion gene summary
Fusion gene informationFusion gene name: TPGS2-DERA
Fusion gene ID: 93316
HgeneTgene
Gene symbol

TPGS2

DERA

Gene ID

25941

51071

Gene nametubulin polyglutamylase complex subunit 2deoxyribose-phosphate aldolase
SynonymsC18orf10|HMFN0601|L17|PGs2CGI-26|DEOC
Cytomap

18q12.2

12p12.3

Type of geneprotein-codingprotein-coding
Descriptiontubulin polyglutamylase complex subunit 2deoxyribose-phosphate aldolase2-deoxy-D-ribose 5-phosphate aldolase2-deoxyribose-5-phosphate aldolase homologdeoxyriboaldolasedeoxyribose-phosphate aldolase (putative)phosphodeoxyriboaldolaseputative deoxyribose-phosphate aldolase
Modification date2020031320200313
UniProtAcc

Q68CL5

Q9Y315

Ensembl transtripts involved in fusion geneENST00000334295, ENST00000587129, 
ENST00000589049, ENST00000590842, 
ENST00000593035, ENST00000383056, 
ENST00000590652, 		ENST00000532573, 
ENST00000428559, ENST00000526530, 
ENST00000532964, 
Fusion gene scores* DoF score3 X 3 X 3=2710 X 7 X 6=420
# samples 39
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/420*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TPGS2 [Title/Abstract] AND DERA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTPGS2(34385337)-DERA(16185476), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDERA

GO:0046121

deoxyribonucleoside catabolic process

9226884


check buttonFusion gene breakpoints across TPGS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DERA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A48C-01ATPGS2chr18

34385337

-DERAchr12

16185476

+


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Fusion Gene ORF analysis for TPGS2-DERA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000334295ENST00000532573TPGS2chr18

34385337

-DERAchr12

16185476

+
5CDS-3UTRENST00000587129ENST00000532573TPGS2chr18

34385337

-DERAchr12

16185476

+
5CDS-3UTRENST00000589049ENST00000532573TPGS2chr18

34385337

-DERAchr12

16185476

+
5CDS-3UTRENST00000590842ENST00000532573TPGS2chr18

34385337

-DERAchr12

16185476

+
5CDS-3UTRENST00000593035ENST00000532573TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000334295ENST00000428559TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000334295ENST00000526530TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000334295ENST00000532964TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000587129ENST00000428559TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000587129ENST00000526530TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000587129ENST00000532964TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000589049ENST00000428559TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000589049ENST00000526530TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000589049ENST00000532964TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000590842ENST00000428559TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000590842ENST00000526530TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000590842ENST00000532964TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000593035ENST00000428559TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000593035ENST00000526530TPGS2chr18

34385337

-DERAchr12

16185476

+
In-frameENST00000593035ENST00000532964TPGS2chr18

34385337

-DERAchr12

16185476

+
intron-3CDSENST00000383056ENST00000428559TPGS2chr18

34385337

-DERAchr12

16185476

+
intron-3CDSENST00000383056ENST00000526530TPGS2chr18

34385337

-DERAchr12

16185476

+
intron-3CDSENST00000383056ENST00000532964TPGS2chr18

34385337

-DERAchr12

16185476

+
intron-3CDSENST00000590652ENST00000428559TPGS2chr18

34385337

-DERAchr12

16185476

+
intron-3CDSENST00000590652ENST00000526530TPGS2chr18

34385337

-DERAchr12

16185476

+
intron-3CDSENST00000590652ENST00000532964TPGS2chr18

34385337

-DERAchr12

16185476

+
intron-3UTRENST00000383056ENST00000532573TPGS2chr18

34385337

-DERAchr12

16185476

+
intron-3UTRENST00000590652ENST00000532573TPGS2chr18

34385337

-DERAchr12

16185476

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000587129TPGS2chr1834385337-ENST00000428559DERAchr1216185476+127941937738233
ENST00000587129TPGS2chr1834385337-ENST00000532964DERAchr1216185476+74441937738233
ENST00000587129TPGS2chr1834385337-ENST00000526530DERAchr1216185476+127341937738233
ENST00000590842TPGS2chr1834385337-ENST00000428559DERAchr1216185476+131745775776233
ENST00000590842TPGS2chr1834385337-ENST00000532964DERAchr1216185476+78245775776233
ENST00000590842TPGS2chr1834385337-ENST00000526530DERAchr1216185476+131145775776233
ENST00000334295TPGS2chr1834385337-ENST00000428559DERAchr1216185476+16708103051129274
ENST00000334295TPGS2chr1834385337-ENST00000532964DERAchr1216185476+11358103051129274
ENST00000334295TPGS2chr1834385337-ENST00000526530DERAchr1216185476+16648103051129274
ENST00000593035TPGS2chr1834385337-ENST00000428559DERAchr1216185476+133347373792239
ENST00000593035TPGS2chr1834385337-ENST00000532964DERAchr1216185476+79847373792239
ENST00000593035TPGS2chr1834385337-ENST00000526530DERAchr1216185476+132747373792239
ENST00000589049TPGS2chr1834385337-ENST00000428559DERAchr1216185476+125639614715233
ENST00000589049TPGS2chr1834385337-ENST00000532964DERAchr1216185476+72139614715233
ENST00000589049TPGS2chr1834385337-ENST00000526530DERAchr1216185476+125039614715233

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000587129ENST00000428559TPGS2chr1834385337-DERAchr1216185476+0.0010217930.99897826
ENST00000587129ENST00000532964TPGS2chr1834385337-DERAchr1216185476+0.0024687110.9975313
ENST00000587129ENST00000526530TPGS2chr1834385337-DERAchr1216185476+0.0010367420.99896324
ENST00000590842ENST00000428559TPGS2chr1834385337-DERAchr1216185476+0.0010814460.99891853
ENST00000590842ENST00000532964TPGS2chr1834385337-DERAchr1216185476+0.0025586960.9974413
ENST00000590842ENST00000526530TPGS2chr1834385337-DERAchr1216185476+0.0011184040.99888164
ENST00000334295ENST00000428559TPGS2chr1834385337-DERAchr1216185476+0.0019975650.99800247
ENST00000334295ENST00000532964TPGS2chr1834385337-DERAchr1216185476+0.0037910560.9962089
ENST00000334295ENST00000526530TPGS2chr1834385337-DERAchr1216185476+0.0020454450.9979545
ENST00000593035ENST00000428559TPGS2chr1834385337-DERAchr1216185476+0.0021417550.9978582
ENST00000593035ENST00000532964TPGS2chr1834385337-DERAchr1216185476+0.0038063820.99619365
ENST00000593035ENST00000526530TPGS2chr1834385337-DERAchr1216185476+0.0020847740.9979152
ENST00000589049ENST00000428559TPGS2chr1834385337-DERAchr1216185476+0.0009846070.99901533
ENST00000589049ENST00000532964TPGS2chr1834385337-DERAchr1216185476+0.0023937040.9976063
ENST00000589049ENST00000526530TPGS2chr1834385337-DERAchr1216185476+0.0010023640.9989976

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Fusion Genomic Features for TPGS2-DERA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TPGS2chr1834385336-DERAchr1216185475+9.04E-050.99990964
TPGS2chr1834385336-DERAchr1216185475+9.04E-050.99990964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TPGS2-DERA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:34385337/chr12:16185476)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPGS2

Q68CL5

DERA

Q9Y315

FUNCTION: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation. {ECO:0000269|PubMed:25229427}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TPGS2-DERA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93316_93316_1_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000334295_DERA_chr12_16185476_ENST00000428559_length(transcript)=1670nt_BP=810nt
GTCCCGGCTCCAGAACGCCGCGGCACTGGGGCGGGAGGGGCCCGCCACGTCCGCCATCTTGAAACAACCGCCACTCGGGGCGTCGCGCCT
GGGCCGCCACGCCTCGGCCTGCAGGCTCGGTCCCCATTGGCCGCACCACGCAGAGGCCCGCCCCCGCCTGCGCGGCCGGCCCCTGCGGGG
CGAGAGGGTGGGGGCGAAGGGGAAGCTACGTCCCGGAGGTGCGGTGTGGGGCACCGGGCGGGGCCGCGGGAACCGGCGCCCCACGGAGCT
GCTGCTGTCAGACCAACCCCGGGCCCCCATCATCACTGCGCCGCGCTTTCAGGCGCCGAGAACTACCGTTCCCGGCATGCCATGAAATTG
GCCTCGGCGCTGAGGCGGGGTCCGGCCCTCCACCCGCTCCCGCCGCGCGCGAATCGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCC
CGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCACGCGCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGA
CCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACAAAAGAATAACTGTGTGATGCCTGAAGATGTGAAGAACT
TTTACCTGATGACCAATGGCTTCCACATGACATGGAGTGTGAAGCTGGATGAGCACATCATTCCACTGGGAAGCATGGCAATTAACAGCA
TCTCAAAACTGACTCAGCTCACCCAGTCTTCCATGTATTCACTTCCTAATGCACCCACTCTGGCAGACCTGGAGGACGATACACATGAAG
GATCAGATTTTATTAAGACCTCTACTGGAAAAGAAACAGTAAATGCCACCTTCCCGGTAGCTATAGTAATGCTGCGGGCCATTAGAGATT
TCTTCTGGAAAACTGGAAACAAGATAGGGTTTAAACCAGCAGGAGGCATCCGCAGTGCAAAGGATTCCCTTGCTTGGCTCTCTCTTGTAA
AGGAGGAGCTTGGAGATGAGTGGCTGAAGCCAGAACTCTTTCGAATAGGTGCCAGTACTCTGCTCTCGGACATTGAGAGGCAGATTTACC
ATCATGTGACTGGAAGATATGCAGCTTATCATGATCTTCCAATGTCTTAAATCAGTCACCAGTTCCAGAAAAGTTCTTTACGACAATGTT
TAAAAATTATTTTTCTACGTAATTGCTAAAATTATTTAATTAAAAAATTGGGCAGTAGGTAACTGGCATTCCTCTCTTTAAAATTTCTAC
CGAACTTAATGGAATGGAAAAAGCAAACTCATCCACATGTGGTACTCATTTCAGGCACATCTGAAATGATCTTAATTACTAGAAGATCTG
CACTATTAACTTTGTGAAGAGTTTCTCCTAAAAACTTTAAGTAAAATGTTAATGGTAGCTTTGATAACATCAAATTCTAAGGGAGAAAAA
AACAATATTAAACCGCCCAAGCAGTGTGCCCTAGCAGAGGAAAATGCAACATCTCGCAAGCGCTGCTGTAACGACTTCAGGAGTCACTGA
TTCAGCACTAATTTCCTGCTGTGAAAACTCATCTTTCATTTTTGCCGTGGATAGGCGCTTTTATTAATTGTTGTCCTAATGAAATTTCTG

>93316_93316_1_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000334295_DERA_chr12_16185476_ENST00000428559_length(amino acids)=274AA_BP=168
MRRAFRRRELPFPACHEIGLGAEAGSGPPPAPAARESRSRAMEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHM
ISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDEHIIPLGSMAINSISKLTQLTQSSMYSLPNAPTLADLEDDTHEGSDFIKTSTGKE
TVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDSLAWLSLVKEELGDEWLKPELFRIGASTLLSDIERQIYHHVTGRYAAYHD

--------------------------------------------------------------
>93316_93316_2_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000334295_DERA_chr12_16185476_ENST00000526530_length(transcript)=1664nt_BP=810nt
GTCCCGGCTCCAGAACGCCGCGGCACTGGGGCGGGAGGGGCCCGCCACGTCCGCCATCTTGAAACAACCGCCACTCGGGGCGTCGCGCCT
GGGCCGCCACGCCTCGGCCTGCAGGCTCGGTCCCCATTGGCCGCACCACGCAGAGGCCCGCCCCCGCCTGCGCGGCCGGCCCCTGCGGGG
CGAGAGGGTGGGGGCGAAGGGGAAGCTACGTCCCGGAGGTGCGGTGTGGGGCACCGGGCGGGGCCGCGGGAACCGGCGCCCCACGGAGCT
GCTGCTGTCAGACCAACCCCGGGCCCCCATCATCACTGCGCCGCGCTTTCAGGCGCCGAGAACTACCGTTCCCGGCATGCCATGAAATTG
GCCTCGGCGCTGAGGCGGGGTCCGGCCCTCCACCCGCTCCCGCCGCGCGCGAATCGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCC
CGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCACGCGCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGA
CCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACAAAAGAATAACTGTGTGATGCCTGAAGATGTGAAGAACT
TTTACCTGATGACCAATGGCTTCCACATGACATGGAGTGTGAAGCTGGATGAGCACATCATTCCACTGGGAAGCATGGCAATTAACAGCA
TCTCAAAACTGACTCAGCTCACCCAGTCTTCCATGTATTCACTTCCTAATGCACCCACTCTGGCAGACCTGGAGGACGATACACATGAAG
GATCAGATTTTATTAAGACCTCTACTGGAAAAGAAACAGTAAATGCCACCTTCCCGGTAGCTATAGTAATGCTGCGGGCCATTAGAGATT
TCTTCTGGAAAACTGGAAACAAGATAGGGTTTAAACCAGCAGGAGGCATCCGCAGTGCAAAGGATTCCCTTGCTTGGCTCTCTCTTGTAA
AGGAGGAGCTTGGAGATGAGTGGCTGAAGCCAGAACTCTTTCGAATAGGTGCCAGTACTCTGCTCTCGGACATTGAGAGGCAGATTTACC
ATCATGTGACTGGAAGATATGCAGCTTATCATGATCTTCCAATGTCTTAAATCAGTCACCAGTTCCAGAAAAGTTCTTTACGACAATGTT
TAAAAATTATTTTTCTACGTAATTGCTAAAATTATTTAATTAAAAAATTGGGCAGTAGGTAACTGGCATTCCTCTCTTTAAAATTTCTAC
CGAACTTAATGGAATGGAAAAAGCAAACTCATCCACATGTGGTACTCATTTCAGGCACATCTGAAATGATCTTAATTACTAGAAGATCTG
CACTATTAACTTTGTGAAGAGTTTCTCCTAAAAACTTTAAGTAAAATGTTAATGGTAGCTTTGATAACATCAAATTCTAAGGGAGAAAAA
AACAATATTAAACCGCCCAAGCAGTGTGCCCTAGCAGAGGAAAATGCAACATCTCGCAAGCGCTGCTGTAACGACTTCAGGAGTCACTGA
TTCAGCACTAATTTCCTGCTGTGAAAACTCATCTTTCATTTTTGCCGTGGATAGGCGCTTTTATTAATTGTTGTCCTAATGAAATTTCTG

>93316_93316_2_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000334295_DERA_chr12_16185476_ENST00000526530_length(amino acids)=274AA_BP=168
MRRAFRRRELPFPACHEIGLGAEAGSGPPPAPAARESRSRAMEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHM
ISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDEHIIPLGSMAINSISKLTQLTQSSMYSLPNAPTLADLEDDTHEGSDFIKTSTGKE
TVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDSLAWLSLVKEELGDEWLKPELFRIGASTLLSDIERQIYHHVTGRYAAYHD

--------------------------------------------------------------
>93316_93316_3_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000334295_DERA_chr12_16185476_ENST00000532964_length(transcript)=1135nt_BP=810nt
GTCCCGGCTCCAGAACGCCGCGGCACTGGGGCGGGAGGGGCCCGCCACGTCCGCCATCTTGAAACAACCGCCACTCGGGGCGTCGCGCCT
GGGCCGCCACGCCTCGGCCTGCAGGCTCGGTCCCCATTGGCCGCACCACGCAGAGGCCCGCCCCCGCCTGCGCGGCCGGCCCCTGCGGGG
CGAGAGGGTGGGGGCGAAGGGGAAGCTACGTCCCGGAGGTGCGGTGTGGGGCACCGGGCGGGGCCGCGGGAACCGGCGCCCCACGGAGCT
GCTGCTGTCAGACCAACCCCGGGCCCCCATCATCACTGCGCCGCGCTTTCAGGCGCCGAGAACTACCGTTCCCGGCATGCCATGAAATTG
GCCTCGGCGCTGAGGCGGGGTCCGGCCCTCCACCCGCTCCCGCCGCGCGCGAATCGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCC
CGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCACGCGCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGA
CCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACAAAAGAATAACTGTGTGATGCCTGAAGATGTGAAGAACT
TTTACCTGATGACCAATGGCTTCCACATGACATGGAGTGTGAAGCTGGATGAGCACATCATTCCACTGGGAAGCATGGCAATTAACAGCA
TCTCAAAACTGACTCAGCTCACCCAGTCTTCCATGTATTCACTTCCTAATGCACCCACTCTGGCAGACCTGGAGGACGATACACATGAAG
GATCAGATTTTATTAAGACCTCTACTGGAAAAGAAACAGTAAATGCCACCTTCCCGGTAGCTATAGTAATGCTGCGGGCCATTAGAGATT
TCTTCTGGAAAACTGGAAACAAGATAGGGTTTAAACCAGCAGGAGGCATCCGCAGTGCAAAGGATTCCCTTGCTTGGCTCTCTCTTGTAA
AGGAGGAGCTTGGAGATGAGTGGCTGAAGCCAGAACTCTTTCGAATAGGTGCCAGTACTCTGCTCTCGGACATTGAGAGGCAGATTTACC

>93316_93316_3_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000334295_DERA_chr12_16185476_ENST00000532964_length(amino acids)=274AA_BP=168
MRRAFRRRELPFPACHEIGLGAEAGSGPPPAPAARESRSRAMEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHM
ISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDEHIIPLGSMAINSISKLTQLTQSSMYSLPNAPTLADLEDDTHEGSDFIKTSTGKE
TVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDSLAWLSLVKEELGDEWLKPELFRIGASTLLSDIERQIYHHVTGRYAAYHD

--------------------------------------------------------------
>93316_93316_4_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000587129_DERA_chr12_16185476_ENST00000428559_length(transcript)=1279nt_BP=419nt
ACCCGCTCCCGCCGCGCGCGAATCGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGA
GAAGCTGACCCTGGGCATCACGCGCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCA
TATGATTTCTTCCTGGGAACAAAAGAATAACTGTGTGATGCCTGAAGATGTGAAGAACTTTTACCTGATGACCAATGGCTTCCACATGAC
ATGGAGTGTGAAGCTGGATGAGCACATCATTCCACTGGGAAGCATGGCAATTAACAGCATCTCAAAACTGACTCAGCTCACCCAGTCTTC
CATGTATTCACTTCCTAATGCACCCACTCTGGCAGACCTGGAGGACGATACACATGAAGGATCAGATTTTATTAAGACCTCTACTGGAAA
AGAAACAGTAAATGCCACCTTCCCGGTAGCTATAGTAATGCTGCGGGCCATTAGAGATTTCTTCTGGAAAACTGGAAACAAGATAGGGTT
TAAACCAGCAGGAGGCATCCGCAGTGCAAAGGATTCCCTTGCTTGGCTCTCTCTTGTAAAGGAGGAGCTTGGAGATGAGTGGCTGAAGCC
AGAACTCTTTCGAATAGGTGCCAGTACTCTGCTCTCGGACATTGAGAGGCAGATTTACCATCATGTGACTGGAAGATATGCAGCTTATCA
TGATCTTCCAATGTCTTAAATCAGTCACCAGTTCCAGAAAAGTTCTTTACGACAATGTTTAAAAATTATTTTTCTACGTAATTGCTAAAA
TTATTTAATTAAAAAATTGGGCAGTAGGTAACTGGCATTCCTCTCTTTAAAATTTCTACCGAACTTAATGGAATGGAAAAAGCAAACTCA
TCCACATGTGGTACTCATTTCAGGCACATCTGAAATGATCTTAATTACTAGAAGATCTGCACTATTAACTTTGTGAAGAGTTTCTCCTAA
AAACTTTAAGTAAAATGTTAATGGTAGCTTTGATAACATCAAATTCTAAGGGAGAAAAAAACAATATTAAACCGCCCAAGCAGTGTGCCC
TAGCAGAGGAAAATGCAACATCTCGCAAGCGCTGCTGTAACGACTTCAGGAGTCACTGATTCAGCACTAATTTCCTGCTGTGAAAACTCA
TCTTTCATTTTTGCCGTGGATAGGCGCTTTTATTAATTGTTGTCCTAATGAAATTTCTGACATTGTCATATACAACGATGAATATCATTA

>93316_93316_4_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000587129_DERA_chr12_16185476_ENST00000428559_length(amino acids)=233AA_BP=127
MEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHMISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDEHIIPL
GSMAINSISKLTQLTQSSMYSLPNAPTLADLEDDTHEGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDS

--------------------------------------------------------------
>93316_93316_5_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000587129_DERA_chr12_16185476_ENST00000526530_length(transcript)=1273nt_BP=419nt
ACCCGCTCCCGCCGCGCGCGAATCGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGA
GAAGCTGACCCTGGGCATCACGCGCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCA
TATGATTTCTTCCTGGGAACAAAAGAATAACTGTGTGATGCCTGAAGATGTGAAGAACTTTTACCTGATGACCAATGGCTTCCACATGAC
ATGGAGTGTGAAGCTGGATGAGCACATCATTCCACTGGGAAGCATGGCAATTAACAGCATCTCAAAACTGACTCAGCTCACCCAGTCTTC
CATGTATTCACTTCCTAATGCACCCACTCTGGCAGACCTGGAGGACGATACACATGAAGGATCAGATTTTATTAAGACCTCTACTGGAAA
AGAAACAGTAAATGCCACCTTCCCGGTAGCTATAGTAATGCTGCGGGCCATTAGAGATTTCTTCTGGAAAACTGGAAACAAGATAGGGTT
TAAACCAGCAGGAGGCATCCGCAGTGCAAAGGATTCCCTTGCTTGGCTCTCTCTTGTAAAGGAGGAGCTTGGAGATGAGTGGCTGAAGCC
AGAACTCTTTCGAATAGGTGCCAGTACTCTGCTCTCGGACATTGAGAGGCAGATTTACCATCATGTGACTGGAAGATATGCAGCTTATCA
TGATCTTCCAATGTCTTAAATCAGTCACCAGTTCCAGAAAAGTTCTTTACGACAATGTTTAAAAATTATTTTTCTACGTAATTGCTAAAA
TTATTTAATTAAAAAATTGGGCAGTAGGTAACTGGCATTCCTCTCTTTAAAATTTCTACCGAACTTAATGGAATGGAAAAAGCAAACTCA
TCCACATGTGGTACTCATTTCAGGCACATCTGAAATGATCTTAATTACTAGAAGATCTGCACTATTAACTTTGTGAAGAGTTTCTCCTAA
AAACTTTAAGTAAAATGTTAATGGTAGCTTTGATAACATCAAATTCTAAGGGAGAAAAAAACAATATTAAACCGCCCAAGCAGTGTGCCC
TAGCAGAGGAAAATGCAACATCTCGCAAGCGCTGCTGTAACGACTTCAGGAGTCACTGATTCAGCACTAATTTCCTGCTGTGAAAACTCA
TCTTTCATTTTTGCCGTGGATAGGCGCTTTTATTAATTGTTGTCCTAATGAAATTTCTGACATTGTCATATACAACGATGAATATCATTA

>93316_93316_5_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000587129_DERA_chr12_16185476_ENST00000526530_length(amino acids)=233AA_BP=127
MEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHMISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDEHIIPL
GSMAINSISKLTQLTQSSMYSLPNAPTLADLEDDTHEGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDS

--------------------------------------------------------------
>93316_93316_6_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000587129_DERA_chr12_16185476_ENST00000532964_length(transcript)=744nt_BP=419nt
ACCCGCTCCCGCCGCGCGCGAATCGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGA
GAAGCTGACCCTGGGCATCACGCGCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCA
TATGATTTCTTCCTGGGAACAAAAGAATAACTGTGTGATGCCTGAAGATGTGAAGAACTTTTACCTGATGACCAATGGCTTCCACATGAC
ATGGAGTGTGAAGCTGGATGAGCACATCATTCCACTGGGAAGCATGGCAATTAACAGCATCTCAAAACTGACTCAGCTCACCCAGTCTTC
CATGTATTCACTTCCTAATGCACCCACTCTGGCAGACCTGGAGGACGATACACATGAAGGATCAGATTTTATTAAGACCTCTACTGGAAA
AGAAACAGTAAATGCCACCTTCCCGGTAGCTATAGTAATGCTGCGGGCCATTAGAGATTTCTTCTGGAAAACTGGAAACAAGATAGGGTT
TAAACCAGCAGGAGGCATCCGCAGTGCAAAGGATTCCCTTGCTTGGCTCTCTCTTGTAAAGGAGGAGCTTGGAGATGAGTGGCTGAAGCC
AGAACTCTTTCGAATAGGTGCCAGTACTCTGCTCTCGGACATTGAGAGGCAGATTTACCATCATGTGACTGGAAGATATGCAGCTTATCA

>93316_93316_6_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000587129_DERA_chr12_16185476_ENST00000532964_length(amino acids)=233AA_BP=127
MEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHMISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDEHIIPL
GSMAINSISKLTQLTQSSMYSLPNAPTLADLEDDTHEGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDS

--------------------------------------------------------------
>93316_93316_7_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000589049_DERA_chr12_16185476_ENST00000428559_length(transcript)=1256nt_BP=396nt
CGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCACGC
GCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACAAA
AGAATAACTGTGTGATGCCTGAAGATGTGAAGAACTTTTACCTGATGACCAATGGCTTCCACATGACATGGAGTGTGAAGCTGGATGAGC
ACATCATTCCACTGGGAAGCATGGCAATTAACAGCATCTCAAAACTGACTCAGCTCACCCAGTCTTCCATGTATTCACTTCCTAATGCAC
CCACTCTGGCAGACCTGGAGGACGATACACATGAAGGATCAGATTTTATTAAGACCTCTACTGGAAAAGAAACAGTAAATGCCACCTTCC
CGGTAGCTATAGTAATGCTGCGGGCCATTAGAGATTTCTTCTGGAAAACTGGAAACAAGATAGGGTTTAAACCAGCAGGAGGCATCCGCA
GTGCAAAGGATTCCCTTGCTTGGCTCTCTCTTGTAAAGGAGGAGCTTGGAGATGAGTGGCTGAAGCCAGAACTCTTTCGAATAGGTGCCA
GTACTCTGCTCTCGGACATTGAGAGGCAGATTTACCATCATGTGACTGGAAGATATGCAGCTTATCATGATCTTCCAATGTCTTAAATCA
GTCACCAGTTCCAGAAAAGTTCTTTACGACAATGTTTAAAAATTATTTTTCTACGTAATTGCTAAAATTATTTAATTAAAAAATTGGGCA
GTAGGTAACTGGCATTCCTCTCTTTAAAATTTCTACCGAACTTAATGGAATGGAAAAAGCAAACTCATCCACATGTGGTACTCATTTCAG
GCACATCTGAAATGATCTTAATTACTAGAAGATCTGCACTATTAACTTTGTGAAGAGTTTCTCCTAAAAACTTTAAGTAAAATGTTAATG
GTAGCTTTGATAACATCAAATTCTAAGGGAGAAAAAAACAATATTAAACCGCCCAAGCAGTGTGCCCTAGCAGAGGAAAATGCAACATCT
CGCAAGCGCTGCTGTAACGACTTCAGGAGTCACTGATTCAGCACTAATTTCCTGCTGTGAAAACTCATCTTTCATTTTTGCCGTGGATAG

>93316_93316_7_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000589049_DERA_chr12_16185476_ENST00000428559_length(amino acids)=233AA_BP=127
MEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHMISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDEHIIPL
GSMAINSISKLTQLTQSSMYSLPNAPTLADLEDDTHEGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDS

--------------------------------------------------------------
>93316_93316_8_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000589049_DERA_chr12_16185476_ENST00000526530_length(transcript)=1250nt_BP=396nt
CGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCACGC
GCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACAAA
AGAATAACTGTGTGATGCCTGAAGATGTGAAGAACTTTTACCTGATGACCAATGGCTTCCACATGACATGGAGTGTGAAGCTGGATGAGC
ACATCATTCCACTGGGAAGCATGGCAATTAACAGCATCTCAAAACTGACTCAGCTCACCCAGTCTTCCATGTATTCACTTCCTAATGCAC
CCACTCTGGCAGACCTGGAGGACGATACACATGAAGGATCAGATTTTATTAAGACCTCTACTGGAAAAGAAACAGTAAATGCCACCTTCC
CGGTAGCTATAGTAATGCTGCGGGCCATTAGAGATTTCTTCTGGAAAACTGGAAACAAGATAGGGTTTAAACCAGCAGGAGGCATCCGCA
GTGCAAAGGATTCCCTTGCTTGGCTCTCTCTTGTAAAGGAGGAGCTTGGAGATGAGTGGCTGAAGCCAGAACTCTTTCGAATAGGTGCCA
GTACTCTGCTCTCGGACATTGAGAGGCAGATTTACCATCATGTGACTGGAAGATATGCAGCTTATCATGATCTTCCAATGTCTTAAATCA
GTCACCAGTTCCAGAAAAGTTCTTTACGACAATGTTTAAAAATTATTTTTCTACGTAATTGCTAAAATTATTTAATTAAAAAATTGGGCA
GTAGGTAACTGGCATTCCTCTCTTTAAAATTTCTACCGAACTTAATGGAATGGAAAAAGCAAACTCATCCACATGTGGTACTCATTTCAG
GCACATCTGAAATGATCTTAATTACTAGAAGATCTGCACTATTAACTTTGTGAAGAGTTTCTCCTAAAAACTTTAAGTAAAATGTTAATG
GTAGCTTTGATAACATCAAATTCTAAGGGAGAAAAAAACAATATTAAACCGCCCAAGCAGTGTGCCCTAGCAGAGGAAAATGCAACATCT
CGCAAGCGCTGCTGTAACGACTTCAGGAGTCACTGATTCAGCACTAATTTCCTGCTGTGAAAACTCATCTTTCATTTTTGCCGTGGATAG

>93316_93316_8_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000589049_DERA_chr12_16185476_ENST00000526530_length(amino acids)=233AA_BP=127
MEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHMISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDEHIIPL
GSMAINSISKLTQLTQSSMYSLPNAPTLADLEDDTHEGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDS

--------------------------------------------------------------
>93316_93316_9_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000589049_DERA_chr12_16185476_ENST00000532964_length(transcript)=721nt_BP=396nt
CGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCACGC
GCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACAAA
AGAATAACTGTGTGATGCCTGAAGATGTGAAGAACTTTTACCTGATGACCAATGGCTTCCACATGACATGGAGTGTGAAGCTGGATGAGC
ACATCATTCCACTGGGAAGCATGGCAATTAACAGCATCTCAAAACTGACTCAGCTCACCCAGTCTTCCATGTATTCACTTCCTAATGCAC
CCACTCTGGCAGACCTGGAGGACGATACACATGAAGGATCAGATTTTATTAAGACCTCTACTGGAAAAGAAACAGTAAATGCCACCTTCC
CGGTAGCTATAGTAATGCTGCGGGCCATTAGAGATTTCTTCTGGAAAACTGGAAACAAGATAGGGTTTAAACCAGCAGGAGGCATCCGCA
GTGCAAAGGATTCCCTTGCTTGGCTCTCTCTTGTAAAGGAGGAGCTTGGAGATGAGTGGCTGAAGCCAGAACTCTTTCGAATAGGTGCCA
GTACTCTGCTCTCGGACATTGAGAGGCAGATTTACCATCATGTGACTGGAAGATATGCAGCTTATCATGATCTTCCAATGTCTTAAATCA

>93316_93316_9_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000589049_DERA_chr12_16185476_ENST00000532964_length(amino acids)=233AA_BP=127
MEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHMISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDEHIIPL
GSMAINSISKLTQLTQSSMYSLPNAPTLADLEDDTHEGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDS

--------------------------------------------------------------
>93316_93316_10_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000590842_DERA_chr12_16185476_ENST00000428559_length(transcript)=1317nt_BP=457nt
GAAATTGGCCTCGGCGCTGAGGCGGGGTCCGGCCCTCCACCCGCTCCCGCCGCGCGCGAATCGCGGTCGCGAGCCATGGAGGAGGAGGCA
TCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCACGCGCATCCTAGAATCTTCCCCAGGTGTGACT
GAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACAAAAGAATAACTGTGTGATGCCTGAAGATGTG
AAGAACTTTTACCTGATGACCAATGGCTTCCACATGACATGGAGTGTGAAGCTGGATGAGCACATCATTCCACTGGGAAGCATGGCAATT
AACAGCATCTCAAAACTGACTCAGCTCACCCAGTCTTCCATGTATTCACTTCCTAATGCACCCACTCTGGCAGACCTGGAGGACGATACA
CATGAAGGATCAGATTTTATTAAGACCTCTACTGGAAAAGAAACAGTAAATGCCACCTTCCCGGTAGCTATAGTAATGCTGCGGGCCATT
AGAGATTTCTTCTGGAAAACTGGAAACAAGATAGGGTTTAAACCAGCAGGAGGCATCCGCAGTGCAAAGGATTCCCTTGCTTGGCTCTCT
CTTGTAAAGGAGGAGCTTGGAGATGAGTGGCTGAAGCCAGAACTCTTTCGAATAGGTGCCAGTACTCTGCTCTCGGACATTGAGAGGCAG
ATTTACCATCATGTGACTGGAAGATATGCAGCTTATCATGATCTTCCAATGTCTTAAATCAGTCACCAGTTCCAGAAAAGTTCTTTACGA
CAATGTTTAAAAATTATTTTTCTACGTAATTGCTAAAATTATTTAATTAAAAAATTGGGCAGTAGGTAACTGGCATTCCTCTCTTTAAAA
TTTCTACCGAACTTAATGGAATGGAAAAAGCAAACTCATCCACATGTGGTACTCATTTCAGGCACATCTGAAATGATCTTAATTACTAGA
AGATCTGCACTATTAACTTTGTGAAGAGTTTCTCCTAAAAACTTTAAGTAAAATGTTAATGGTAGCTTTGATAACATCAAATTCTAAGGG
AGAAAAAAACAATATTAAACCGCCCAAGCAGTGTGCCCTAGCAGAGGAAAATGCAACATCTCGCAAGCGCTGCTGTAACGACTTCAGGAG
TCACTGATTCAGCACTAATTTCCTGCTGTGAAAACTCATCTTTCATTTTTGCCGTGGATAGGCGCTTTTATTAATTGTTGTCCTAATGAA

>93316_93316_10_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000590842_DERA_chr12_16185476_ENST00000428559_length(amino acids)=233AA_BP=127
MEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHMISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDEHIIPL
GSMAINSISKLTQLTQSSMYSLPNAPTLADLEDDTHEGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDS

--------------------------------------------------------------
>93316_93316_11_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000590842_DERA_chr12_16185476_ENST00000526530_length(transcript)=1311nt_BP=457nt
GAAATTGGCCTCGGCGCTGAGGCGGGGTCCGGCCCTCCACCCGCTCCCGCCGCGCGCGAATCGCGGTCGCGAGCCATGGAGGAGGAGGCA
TCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCACGCGCATCCTAGAATCTTCCCCAGGTGTGACT
GAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACAAAAGAATAACTGTGTGATGCCTGAAGATGTG
AAGAACTTTTACCTGATGACCAATGGCTTCCACATGACATGGAGTGTGAAGCTGGATGAGCACATCATTCCACTGGGAAGCATGGCAATT
AACAGCATCTCAAAACTGACTCAGCTCACCCAGTCTTCCATGTATTCACTTCCTAATGCACCCACTCTGGCAGACCTGGAGGACGATACA
CATGAAGGATCAGATTTTATTAAGACCTCTACTGGAAAAGAAACAGTAAATGCCACCTTCCCGGTAGCTATAGTAATGCTGCGGGCCATT
AGAGATTTCTTCTGGAAAACTGGAAACAAGATAGGGTTTAAACCAGCAGGAGGCATCCGCAGTGCAAAGGATTCCCTTGCTTGGCTCTCT
CTTGTAAAGGAGGAGCTTGGAGATGAGTGGCTGAAGCCAGAACTCTTTCGAATAGGTGCCAGTACTCTGCTCTCGGACATTGAGAGGCAG
ATTTACCATCATGTGACTGGAAGATATGCAGCTTATCATGATCTTCCAATGTCTTAAATCAGTCACCAGTTCCAGAAAAGTTCTTTACGA
CAATGTTTAAAAATTATTTTTCTACGTAATTGCTAAAATTATTTAATTAAAAAATTGGGCAGTAGGTAACTGGCATTCCTCTCTTTAAAA
TTTCTACCGAACTTAATGGAATGGAAAAAGCAAACTCATCCACATGTGGTACTCATTTCAGGCACATCTGAAATGATCTTAATTACTAGA
AGATCTGCACTATTAACTTTGTGAAGAGTTTCTCCTAAAAACTTTAAGTAAAATGTTAATGGTAGCTTTGATAACATCAAATTCTAAGGG
AGAAAAAAACAATATTAAACCGCCCAAGCAGTGTGCCCTAGCAGAGGAAAATGCAACATCTCGCAAGCGCTGCTGTAACGACTTCAGGAG
TCACTGATTCAGCACTAATTTCCTGCTGTGAAAACTCATCTTTCATTTTTGCCGTGGATAGGCGCTTTTATTAATTGTTGTCCTAATGAA

>93316_93316_11_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000590842_DERA_chr12_16185476_ENST00000526530_length(amino acids)=233AA_BP=127
MEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHMISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDEHIIPL
GSMAINSISKLTQLTQSSMYSLPNAPTLADLEDDTHEGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDS

--------------------------------------------------------------
>93316_93316_12_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000590842_DERA_chr12_16185476_ENST00000532964_length(transcript)=782nt_BP=457nt
GAAATTGGCCTCGGCGCTGAGGCGGGGTCCGGCCCTCCACCCGCTCCCGCCGCGCGCGAATCGCGGTCGCGAGCCATGGAGGAGGAGGCA
TCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCACGCGCATCCTAGAATCTTCCCCAGGTGTGACT
GAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACAAAAGAATAACTGTGTGATGCCTGAAGATGTG
AAGAACTTTTACCTGATGACCAATGGCTTCCACATGACATGGAGTGTGAAGCTGGATGAGCACATCATTCCACTGGGAAGCATGGCAATT
AACAGCATCTCAAAACTGACTCAGCTCACCCAGTCTTCCATGTATTCACTTCCTAATGCACCCACTCTGGCAGACCTGGAGGACGATACA
CATGAAGGATCAGATTTTATTAAGACCTCTACTGGAAAAGAAACAGTAAATGCCACCTTCCCGGTAGCTATAGTAATGCTGCGGGCCATT
AGAGATTTCTTCTGGAAAACTGGAAACAAGATAGGGTTTAAACCAGCAGGAGGCATCCGCAGTGCAAAGGATTCCCTTGCTTGGCTCTCT
CTTGTAAAGGAGGAGCTTGGAGATGAGTGGCTGAAGCCAGAACTCTTTCGAATAGGTGCCAGTACTCTGCTCTCGGACATTGAGAGGCAG

>93316_93316_12_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000590842_DERA_chr12_16185476_ENST00000532964_length(amino acids)=233AA_BP=127
MEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHMISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDEHIIPL
GSMAINSISKLTQLTQSSMYSLPNAPTLADLEDDTHEGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDS

--------------------------------------------------------------
>93316_93316_13_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000593035_DERA_chr12_16185476_ENST00000428559_length(transcript)=1333nt_BP=473nt
ACCGGGCGGGGCCGCGGGAACCGGCGCCCCACGGAGCTGCTGCTGTCAGACCAACCCCGGGCCCCCATCATCACTGCGCCGCGCTTTCAG
GCGCCGAGAACTACCGTTCCCGGCATGCCATGAAATTGGCCTCGGCGCTGAGGCGGGGTCCGGCCCTCCACCCGCTCCCGCCGCGCGCGA
ATCGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCAC
GCGCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACA
AAAGAATAACTGTGTGATGCCTGAAGATGTGAAGAACTTTTACCTGATGACCAATGGCTTCCACATGACATGGAGTGTGAAGCTGGATGA
CCTGGAGGACGATACACATGAAGGATCAGATTTTATTAAGACCTCTACTGGAAAAGAAACAGTAAATGCCACCTTCCCGGTAGCTATAGT
AATGCTGCGGGCCATTAGAGATTTCTTCTGGAAAACTGGAAACAAGATAGGGTTTAAACCAGCAGGAGGCATCCGCAGTGCAAAGGATTC
CCTTGCTTGGCTCTCTCTTGTAAAGGAGGAGCTTGGAGATGAGTGGCTGAAGCCAGAACTCTTTCGAATAGGTGCCAGTACTCTGCTCTC
GGACATTGAGAGGCAGATTTACCATCATGTGACTGGAAGATATGCAGCTTATCATGATCTTCCAATGTCTTAAATCAGTCACCAGTTCCA
GAAAAGTTCTTTACGACAATGTTTAAAAATTATTTTTCTACGTAATTGCTAAAATTATTTAATTAAAAAATTGGGCAGTAGGTAACTGGC
ATTCCTCTCTTTAAAATTTCTACCGAACTTAATGGAATGGAAAAAGCAAACTCATCCACATGTGGTACTCATTTCAGGCACATCTGAAAT
GATCTTAATTACTAGAAGATCTGCACTATTAACTTTGTGAAGAGTTTCTCCTAAAAACTTTAAGTAAAATGTTAATGGTAGCTTTGATAA
CATCAAATTCTAAGGGAGAAAAAAACAATATTAAACCGCCCAAGCAGTGTGCCCTAGCAGAGGAAAATGCAACATCTCGCAAGCGCTGCT
GTAACGACTTCAGGAGTCACTGATTCAGCACTAATTTCCTGCTGTGAAAACTCATCTTTCATTTTTGCCGTGGATAGGCGCTTTTATTAA

>93316_93316_13_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000593035_DERA_chr12_16185476_ENST00000428559_length(amino acids)=239AA_BP=133
MRRAFRRRELPFPACHEIGLGAEAGSGPPPAPAARESRSRAMEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHM
ISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDDLEDDTHEGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGI

--------------------------------------------------------------
>93316_93316_14_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000593035_DERA_chr12_16185476_ENST00000526530_length(transcript)=1327nt_BP=473nt
ACCGGGCGGGGCCGCGGGAACCGGCGCCCCACGGAGCTGCTGCTGTCAGACCAACCCCGGGCCCCCATCATCACTGCGCCGCGCTTTCAG
GCGCCGAGAACTACCGTTCCCGGCATGCCATGAAATTGGCCTCGGCGCTGAGGCGGGGTCCGGCCCTCCACCCGCTCCCGCCGCGCGCGA
ATCGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCAC
GCGCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACA
AAAGAATAACTGTGTGATGCCTGAAGATGTGAAGAACTTTTACCTGATGACCAATGGCTTCCACATGACATGGAGTGTGAAGCTGGATGA
CCTGGAGGACGATACACATGAAGGATCAGATTTTATTAAGACCTCTACTGGAAAAGAAACAGTAAATGCCACCTTCCCGGTAGCTATAGT
AATGCTGCGGGCCATTAGAGATTTCTTCTGGAAAACTGGAAACAAGATAGGGTTTAAACCAGCAGGAGGCATCCGCAGTGCAAAGGATTC
CCTTGCTTGGCTCTCTCTTGTAAAGGAGGAGCTTGGAGATGAGTGGCTGAAGCCAGAACTCTTTCGAATAGGTGCCAGTACTCTGCTCTC
GGACATTGAGAGGCAGATTTACCATCATGTGACTGGAAGATATGCAGCTTATCATGATCTTCCAATGTCTTAAATCAGTCACCAGTTCCA
GAAAAGTTCTTTACGACAATGTTTAAAAATTATTTTTCTACGTAATTGCTAAAATTATTTAATTAAAAAATTGGGCAGTAGGTAACTGGC
ATTCCTCTCTTTAAAATTTCTACCGAACTTAATGGAATGGAAAAAGCAAACTCATCCACATGTGGTACTCATTTCAGGCACATCTGAAAT
GATCTTAATTACTAGAAGATCTGCACTATTAACTTTGTGAAGAGTTTCTCCTAAAAACTTTAAGTAAAATGTTAATGGTAGCTTTGATAA
CATCAAATTCTAAGGGAGAAAAAAACAATATTAAACCGCCCAAGCAGTGTGCCCTAGCAGAGGAAAATGCAACATCTCGCAAGCGCTGCT
GTAACGACTTCAGGAGTCACTGATTCAGCACTAATTTCCTGCTGTGAAAACTCATCTTTCATTTTTGCCGTGGATAGGCGCTTTTATTAA

>93316_93316_14_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000593035_DERA_chr12_16185476_ENST00000526530_length(amino acids)=239AA_BP=133
MRRAFRRRELPFPACHEIGLGAEAGSGPPPAPAARESRSRAMEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHM
ISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDDLEDDTHEGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGI

--------------------------------------------------------------
>93316_93316_15_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000593035_DERA_chr12_16185476_ENST00000532964_length(transcript)=798nt_BP=473nt
ACCGGGCGGGGCCGCGGGAACCGGCGCCCCACGGAGCTGCTGCTGTCAGACCAACCCCGGGCCCCCATCATCACTGCGCCGCGCTTTCAG
GCGCCGAGAACTACCGTTCCCGGCATGCCATGAAATTGGCCTCGGCGCTGAGGCGGGGTCCGGCCCTCCACCCGCTCCCGCCGCGCGCGA
ATCGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCAC
GCGCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACA
AAAGAATAACTGTGTGATGCCTGAAGATGTGAAGAACTTTTACCTGATGACCAATGGCTTCCACATGACATGGAGTGTGAAGCTGGATGA
CCTGGAGGACGATACACATGAAGGATCAGATTTTATTAAGACCTCTACTGGAAAAGAAACAGTAAATGCCACCTTCCCGGTAGCTATAGT
AATGCTGCGGGCCATTAGAGATTTCTTCTGGAAAACTGGAAACAAGATAGGGTTTAAACCAGCAGGAGGCATCCGCAGTGCAAAGGATTC
CCTTGCTTGGCTCTCTCTTGTAAAGGAGGAGCTTGGAGATGAGTGGCTGAAGCCAGAACTCTTTCGAATAGGTGCCAGTACTCTGCTCTC

>93316_93316_15_TPGS2-DERA_TPGS2_chr18_34385337_ENST00000593035_DERA_chr12_16185476_ENST00000532964_length(amino acids)=239AA_BP=133
MRRAFRRRELPFPACHEIGLGAEAGSGPPPAPAARESRSRAMEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHM
ISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDDLEDDTHEGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGI

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Fusion Gene PPI Analysis for TPGS2-DERA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TPGS2-DERA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TPGS2-DERA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource