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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TPGS2-DSG1 (FusionGDB2 ID:93317)

Fusion Gene Summary for TPGS2-DSG1

check button Fusion gene summary
Fusion gene informationFusion gene name: TPGS2-DSG1
Fusion gene ID: 93317
HgeneTgene
Gene symbol

TPGS2

DSG1

Gene ID

25941

1828

Gene nametubulin polyglutamylase complex subunit 2desmoglein 1
SynonymsC18orf10|HMFN0601|L17|PGs2CDHF4|DG1|DSG|EPKHE|EPKHIA|PPKS1|SPPK1
Cytomap

18q12.2

18q12.1

Type of geneprotein-codingprotein-coding
Descriptiontubulin polyglutamylase complex subunit 2desmoglein-1cadherin family member 4desmosomal glycoprotein 1pemphigus foliaceus antigen
Modification date2020031320200313
UniProtAcc

Q68CL5

Q02413

Ensembl transtripts involved in fusion geneENST00000334295, ENST00000383056, 
ENST00000587129, ENST00000589049, 
ENST00000590842, ENST00000593035, 
ENST00000590652, 		ENST00000257192, 
ENST00000462981, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 5 X 3=45
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TPGS2 [Title/Abstract] AND DSG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTPGS2(34398857)-DSG1(28906544), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDSG1

GO:0050821

protein stabilization

7983064


check buttonFusion gene breakpoints across TPGS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DSG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-D5-6929-01ATPGS2chr18

34398857

-DSG1chr18

28898179

+
ChimerDB4COADTCGA-D5-6929-01ATPGS2chr18

34398857

-DSG1chr18

28906544

+


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Fusion Gene ORF analysis for TPGS2-DSG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000334295ENST00000257192TPGS2chr18

34398857

-DSG1chr18

28898179

+
5CDS-5UTRENST00000383056ENST00000257192TPGS2chr18

34398857

-DSG1chr18

28898179

+
5CDS-5UTRENST00000587129ENST00000257192TPGS2chr18

34398857

-DSG1chr18

28898179

+
5CDS-5UTRENST00000589049ENST00000257192TPGS2chr18

34398857

-DSG1chr18

28898179

+
5CDS-5UTRENST00000590842ENST00000257192TPGS2chr18

34398857

-DSG1chr18

28898179

+
5CDS-5UTRENST00000593035ENST00000257192TPGS2chr18

34398857

-DSG1chr18

28898179

+
5CDS-intronENST00000334295ENST00000462981TPGS2chr18

34398857

-DSG1chr18

28898179

+
5CDS-intronENST00000334295ENST00000462981TPGS2chr18

34398857

-DSG1chr18

28906544

+
5CDS-intronENST00000383056ENST00000462981TPGS2chr18

34398857

-DSG1chr18

28898179

+
5CDS-intronENST00000383056ENST00000462981TPGS2chr18

34398857

-DSG1chr18

28906544

+
5CDS-intronENST00000587129ENST00000462981TPGS2chr18

34398857

-DSG1chr18

28898179

+
5CDS-intronENST00000587129ENST00000462981TPGS2chr18

34398857

-DSG1chr18

28906544

+
5CDS-intronENST00000589049ENST00000462981TPGS2chr18

34398857

-DSG1chr18

28898179

+
5CDS-intronENST00000589049ENST00000462981TPGS2chr18

34398857

-DSG1chr18

28906544

+
5CDS-intronENST00000590842ENST00000462981TPGS2chr18

34398857

-DSG1chr18

28898179

+
5CDS-intronENST00000590842ENST00000462981TPGS2chr18

34398857

-DSG1chr18

28906544

+
5CDS-intronENST00000593035ENST00000462981TPGS2chr18

34398857

-DSG1chr18

28898179

+
5CDS-intronENST00000593035ENST00000462981TPGS2chr18

34398857

-DSG1chr18

28906544

+
In-frameENST00000334295ENST00000257192TPGS2chr18

34398857

-DSG1chr18

28906544

+
In-frameENST00000383056ENST00000257192TPGS2chr18

34398857

-DSG1chr18

28906544

+
In-frameENST00000587129ENST00000257192TPGS2chr18

34398857

-DSG1chr18

28906544

+
In-frameENST00000589049ENST00000257192TPGS2chr18

34398857

-DSG1chr18

28906544

+
In-frameENST00000590842ENST00000257192TPGS2chr18

34398857

-DSG1chr18

28906544

+
In-frameENST00000593035ENST00000257192TPGS2chr18

34398857

-DSG1chr18

28906544

+
intron-3CDSENST00000590652ENST00000257192TPGS2chr18

34398857

-DSG1chr18

28906544

+
intron-5UTRENST00000590652ENST00000257192TPGS2chr18

34398857

-DSG1chr18

28898179

+
intron-intronENST00000590652ENST00000462981TPGS2chr18

34398857

-DSG1chr18

28898179

+
intron-intronENST00000590652ENST00000462981TPGS2chr18

34398857

-DSG1chr18

28906544

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000587129TPGS2chr1834398857-ENST00000257192DSG1chr1828906544+49872023733031088
ENST00000590842TPGS2chr1834398857-ENST00000257192DSG1chr1828906544+50252407533411088
ENST00000334295TPGS2chr1834398857-ENST00000257192DSG1chr1828906544+537859330536941129
ENST00000593035TPGS2chr1834398857-ENST00000257192DSG1chr1828906544+51463617334621129
ENST00000383056TPGS2chr1834398857-ENST00000257192DSG1chr1828906544+51693849634851129
ENST00000589049TPGS2chr1834398857-ENST00000257192DSG1chr1828906544+49641791432801088

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000587129ENST00000257192TPGS2chr1834398857-DSG1chr1828906544+0.0001340160.999866
ENST00000590842ENST00000257192TPGS2chr1834398857-DSG1chr1828906544+0.0001413720.9998586
ENST00000334295ENST00000257192TPGS2chr1834398857-DSG1chr1828906544+0.0002415230.9997584
ENST00000593035ENST00000257192TPGS2chr1834398857-DSG1chr1828906544+0.0001750640.99982494
ENST00000383056ENST00000257192TPGS2chr1834398857-DSG1chr1828906544+0.0001730080.99982697
ENST00000589049ENST00000257192TPGS2chr1834398857-DSG1chr1828906544+0.000132570.99986744

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Fusion Genomic Features for TPGS2-DSG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TPGS2chr1834398856-DSG1chr1828906543+0.0012058760.9987941
TPGS2chr1834398856-DSG1chr1828906543+0.0012058760.9987941

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TPGS2-DSG1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:34398857/chr18:28906544)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPGS2

Q68CL5

DSG1

Q02413

FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDSG1chr18:34398857chr18:28906544ENST00000257192015969_1019161050.0Compositional biasNote=Gly/Ser-rich
TgeneDSG1chr18:34398857chr18:28906544ENST00000257192015159_270161050.0DomainCadherin 2
TgeneDSG1chr18:34398857chr18:28906544ENST00000257192015271_385161050.0DomainCadherin 3
TgeneDSG1chr18:34398857chr18:28906544ENST00000257192015386_497161050.0DomainCadherin 4
TgeneDSG1chr18:34398857chr18:28906544ENST0000025719201550_158161050.0DomainCadherin 1
TgeneDSG1chr18:34398857chr18:28906544ENST00000257192015813_839161050.0RepeatNote=Desmoglein repeat 1
TgeneDSG1chr18:34398857chr18:28906544ENST00000257192015840_869161050.0RepeatNote=Desmoglein repeat 2
TgeneDSG1chr18:34398857chr18:28906544ENST00000257192015870_899161050.0RepeatNote=Desmoglein repeat 3
TgeneDSG1chr18:34398857chr18:28906544ENST00000257192015900_927161050.0RepeatNote=Desmoglein repeat 4
TgeneDSG1chr18:34398857chr18:28906544ENST00000257192015928_956161050.0RepeatNote=Desmoglein repeat 5
TgeneDSG1chr18:34398857chr18:28906544ENST0000025719201550_548161050.0Topological domainExtracellular
TgeneDSG1chr18:34398857chr18:28906544ENST00000257192015570_1049161050.0Topological domainCytoplasmic
TgeneDSG1chr18:34398857chr18:28906544ENST00000257192015549_569161050.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TPGS2-DSG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93317_93317_1_TPGS2-DSG1_TPGS2_chr18_34398857_ENST00000334295_DSG1_chr18_28906544_ENST00000257192_length(transcript)=5378nt_BP=593nt
GTCCCGGCTCCAGAACGCCGCGGCACTGGGGCGGGAGGGGCCCGCCACGTCCGCCATCTTGAAACAACCGCCACTCGGGGCGTCGCGCCT
GGGCCGCCACGCCTCGGCCTGCAGGCTCGGTCCCCATTGGCCGCACCACGCAGAGGCCCGCCCCCGCCTGCGCGGCCGGCCCCTGCGGGG
CGAGAGGGTGGGGGCGAAGGGGAAGCTACGTCCCGGAGGTGCGGTGTGGGGCACCGGGCGGGGCCGCGGGAACCGGCGCCCCACGGAGCT
GCTGCTGTCAGACCAACCCCGGGCCCCCATCATCACTGCGCCGCGCTTTCAGGCGCCGAGAACTACCGTTCCCGGCATGCCATGAAATTG
GCCTCGGCGCTGAGGCGGGGTCCGGCCCTCCACCCGCTCCCGCCGCGCGCGAATCGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCC
CGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCACGCGCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGA
CCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACAAGTGGTGGTAGAAGTTAACAGTGAATTCCGAATCCAGG
TAAGAGATTATAACACTAAAAATGGCACCATCAAATGGCATTCAATCCGAAGGCAGAAACGTGAATGGATCAAGTTCGCAGCAGCCTGTC
GTGAAGGTGAAGACAACTCAAAGAGGAACCCAATCGCCAAAATTCACTCAGATTGTGCTGCAAACCAGCAAGTTACATACCGCATCTCTG
GAGTAGGAATTGATCAGCCACCATATGGGATCTTTGTCATTAATCAGAAAACTGGTGAAATTAATATAACATCCATAGTTGATCGAGAGG
TCACTCCTTTCTTCATTATCTACTGCCGAGCTCTGAACTCAATGGGCCAAGATTTAGAGAGGCCTCTAGAGCTCAGAGTCAGGGTTTTGG
ATATAAATGACAACCCTCCAGTGTTTTCAATGGCTACATTTGCAGGACAAATAGAAGAAAATTCTAATGCAAATACACTGGTGATGATAC
TCAATGCTACTGACGCAGATGAACCGAACAATTTGAACTCAAAAATAGCCTTCAAGATTATAAGACAAGAACCTTCAGATTCACCAATGT
TTATTATCAACAGAAATACTGGAGAAATTCGAACGATGAATAATTTTCTAGACAGAGAGCAATACGGCCAGTATGCTCTTGCTGTAAGAG
GCTCTGACCGAGATGGCGGGGCAGATGGCATGTCAGCGGAATGTGAGTGCAACATTAAAATCCTCGATGTCAATGATAATATCCCTTACA
TGGAACAGTCTTCATATACCATAGAAATTCAAGAAAATACTCTAAATTCAAATTTGCTCGAGATTAGAGTAATTGATTTGGATGAAGAGT
TCTCAGCTAACTGGATGGCAGTAATTTTCTTTATCTCTGGAAATGAAGGAAATTGGTTTGAGATAGAAATGAATGAAAGAACAAATGTGG
GAATTTTAAAGGTTGTTAAGCCCTTAGATTATGAAGCTATGCAGAGTCTGCAACTCAGTATTGGTGTCAGAAATAAAGCTGAATTTCATC
ATTCAATTATGTCTCAATATAAACTGAAAGCATCTGCAATTTCTGTGACTGTGTTAAATGTAATTGAAGGCCCAGTGTTTCGTCCAGGTT
CAAAGACATATGTTGTAACTGGTAATATGGGATCAAATGATAAAGTGGGAGACTTTGTAGCTACTGACCTGGACACAGGTAGACCTTCAA
CGACTGTTAGGTATGTAATGGGAAATAATCCAGCTGACCTGCTAGCTGTTGATTCAAGAACAGGCAAACTCACTTTGAAAAATAAAGTTA
CCAAGGAACAGTACAATATGCTCGGAGGAAAATACCAAGGAACGATTCTCTCTATAGATGATAATCTTCAAAGAACTTGCACTGGTACAA
TTAATATTAACATTCAAAGTTTTGGTAATGACGACAGGACTAATACAGAGCCGAACACTAAAATTACTACCAATACTGGCAGACAAGAAA
GTACTTCTTCCACTAACTATGATACCAGCACAACTTCTACTGACTCTAGCCAAGTATATTCTTCTGAACCCGGAAACGGAGCCAAAGATT
TGTTATCAGACAATGTACATTTTGGTCCTGCTGGCATTGGACTCCTCATCATGGGATTCTTGGTCTTAGGATTGGTCCCATTTTTGATGA
TCTGTTGTGATTGTGGAGGTGCTCCTCGTAGTGCAGCTGGCTTTGAGCCTGTTCCCGAATGTTCAGATGGAGCAATTCATTCATGGGCAG
TAGAAGGACCACAGCCTGAACCCAGGGATATAACCACTGTCATACCACAAATACCACCTGATAACGCAAATATAATTGAATGCATTGACA
ACTCAGGAGTTTATACAAATGAGTATGGTGGCAGAGAAATGCAAGATCTGGGAGGAGGAGAGAGAATGACAGGATTTGAACTAACAGAGG
GAGTTAAAACTTCAGGAATGCCTGAGATATGTCAAGAATACTCTGGAACATTAAGAAGAAATTCTATGAGGGAATGTAGAGAAGGAGGTC
TGAATATGAATTTCATGGAAAGCTACTTCTGTCAGAAAGCATATGCTTACGCAGATGAAGATGAAGGACGCCCATCTAATGACTGTTTGC
TCATATATGACATCGAAGGTGTAGGTTCCCCTGCTGGCTCTGTGGGTTGTTGTAGCTTCATTGGAGAAGACCTGGATGACAGCTTCTTGG
ATACCCTGGGACCTAAATTTAAGAAGTTGGCAGACATCAGCCTAGGAAAAGAATCATATCCAGACCTTGATCCTTCTTGGCCACCACAAA
GCACTGAACCAGTTTGCCTTCCTCAGGAAACAGAGCCCGTTGTTAGTGGACACCCACCAATCTCCCCACATTTCGGCACTACCACAGTAA
TTTCTGAGAGCACCTATCCCTCGGGACCTGGTGTACTGCATCCTAAGCCTATTCTCGATCCTCTGGGCTATGGTAATGTCACTGTGACCG
AGTCTTACACCACCTCTGACACTCTGAAGCCCTCTGTGCACGTTCACGATAACCGACCAGCATCAAACGTGGTAGTGACAGAGAGAGTGG
TCGGCCCAATCTCTGGCGCTGATTTGCATGGAATGTTAGAGATGCCTGACTTGCGAGATGGGTCGAATGTTATAGTGACAGAAAGGGTAA
TAGCACCAAGCTCTAGTCTACCCACCTCTCTGACTATCCATCATCCTAGAGAGTCTTCAAATGTGGTAGTGACAGAAAGAGTAATCCAAC
CAACTTCCGGCATGATAGGTAGTCTGAGTATGCACCCCGAGTTAGCCAATGCCCACAATGTCATTGTGACAGAGAGGGTTGTTTCTGGTG
CTGGCGTAACTGGAATTAGTGGCACCACTGGGATCAGCGGTGGCATAGGCAGCAGTGGCCTGGTTGGCACCAGCATGGGTGCTGGGAGCG
GTGCCCTGAGTGGAGCTGGCATAAGTGGTGGTGGCATTGGCCTGAGCAGCTTGGGAGGGACAGCCAGCATTGGCCACATGAGGAGTTCCT
CTGACCATCACTTTAACCAAACCATTGGGTCCGCCTCCCCTAGCACAGCTCGAAGTCGAATCACAAAGTATAGTACCGTGCAATATAGCA
AGTAGTCAGGACCCCAGCTCACTTTTTCATAGTCATTGTGGTTTAGATCCAATTCCCACCACTAAAAAACCAACAATGTGATTTATAACG
CACAACTTCGTGCTCAGGTCATCTAGGAGCAAGGTGAGAAATCACAATGAGAAAAATAAATGGAAACACCACTGCTAGGGGAGAGCTCTC
CTTAGCATTCATAAACTTTTCTCTTATATTAGGACTAAGGAACTAAAACTTGAGGCAGAGTCTTCTTTGTGCCTGAGTGGCCTGTAGTCC
ATCTCCAGCATGTAACTGGCCTTACGATGGCAATTGGCATCATTCTCCTTGCTCTGTTTTGCTTTTCCATATAGCTCGAGCAAAATTCAA
AAAGAACTAAATATGCAATATATGTTCATATCTATGGGAAAAATCTAAAATGTGTGCCAGATGCCCTGTTGGTTTCACAGATAACATAAA
TAAAAATTCAACCACAGATTTATACAAGGGTTAACCATTTTTTTTAAGTTTGACTACATAGTCAAGTCCACAAGCCATCAAGCACTCCTA
CCTTAATTATTGCACTAGAGAAAATAAATTCCAAATTAGGAAGTGTTTCCTAGGAGGAAAATTCCATTAGAGAGTGGCAATAGGATGAGG
TTTCTTCAGGGTAAACTAGCAATGCCTGAGCCTGAACCTTAATGTGGGGCCTCAGTTAAATCTCCTGTGGAGTCAAGGATTCTTCTGATT
CTAGTGTGTGTTTAGTGATAGATGTAGTCTTGACGAATATTGCTTACTGGTGAGGTTGAGGAATATCACACTCGTCTTTCCCTTTACCAC
TGTGGTTTTGACTTAAGAAAGCAAAACTCACTAAGTTTACTTCTCGAATTGAAGCAAGTGAGGCCTGACATGGTTGTCATCACTAGTGGC
AAATGACCTTCCAAGTAAGCAGATGGGAACTGAATTGTGTTTTCAGGTTTTGTTTTTAGTAGGTGATATTCATTCGTATCCAGCTCTTTA
TTACATAGCTCTGAAGTTAAAATGATTTACATAGGCCGAGCTGTGGACAAAAAAAAAAGAAGCAGCAGCTTGTAGTATGCTTAAGCTTTG
GGGAATTTTTTTTTAAGGGGATCTAAAAAAATGTTTTTAGAACATGTAAAATGTTTAATGGTGAAAGTTGGAAAAGAATTCTTCTGTAAA
GTAATACCATGCTAATTATTCGCTTTTAGTAAGTAAAGTAGTGGTTGCTTTAGCAAACCTCTGCTGCCATTTTGCAGGAATCAACCAGGA
ACCTTTAGCAGAATTGACAATATGGTGTTGATAAGCATGAAATAATAATAGAAACCTATTCTGCTAGTTTATCTCACCCTCTAATTTTTC
TCACTAGCATAAATTTTAAATTCCTGATTTGATTTGTCAATAAGATCTTGGCTTATATATGCTGATTTATAGGTAGTGTCCAAATTATAT
AGTATAACATATTTTTCTAGTTTCAAAATTTAGTAATGTCCTATTTATGATATATCATTTCTGTGTGTTTGCTATGTAGTATTACCCAAT
TAAAAATCTCTAAAAAGAATTAAAGCATTCTAAGAAAAAGGTAAATTTACTATTGCATGGTACAGAAATTTTTTCTTTCTTAAATACAAT

>93317_93317_1_TPGS2-DSG1_TPGS2_chr18_34398857_ENST00000334295_DSG1_chr18_28906544_ENST00000257192_length(amino acids)=1129AA_BP=95
MRRAFRRRELPFPACHEIGLGAEAGSGPPPAPAARESRSRAMEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHM
ISSWEQVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIF
VINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNL
NSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQE
NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKAS
AISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKY
QGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAG
IGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGR
EMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPA
GSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGV
LHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLT
IHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGG

--------------------------------------------------------------
>93317_93317_2_TPGS2-DSG1_TPGS2_chr18_34398857_ENST00000383056_DSG1_chr18_28906544_ENST00000257192_length(transcript)=5169nt_BP=384nt
GTCCCGGAGGTGCGGTGTGGGGCACCGGGCGGGGCCGCGGGAACCGGCGCCCCACGGAGCTGCTGCTGTCAGACCAACCCCGGGCCCCCA
TCATCACTGCGCCGCGCTTTCAGGCGCCGAGAACTACCGTTCCCGGCATGCCATGAAATTGGCCTCGGCGCTGAGGCGGGGTCCGGCCCT
CCACCCGCTCCCGCCGCGCGCGAATCGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTG
GAGAAGCTGACCCTGGGCATCACGCGCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGT
CATATGATTTCTTCCTGGGAACAAGTGGTGGTAGAAGTTAACAGTGAATTCCGAATCCAGGTAAGAGATTATAACACTAAAAATGGCACC
ATCAAATGGCATTCAATCCGAAGGCAGAAACGTGAATGGATCAAGTTCGCAGCAGCCTGTCGTGAAGGTGAAGACAACTCAAAGAGGAAC
CCAATCGCCAAAATTCACTCAGATTGTGCTGCAAACCAGCAAGTTACATACCGCATCTCTGGAGTAGGAATTGATCAGCCACCATATGGG
ATCTTTGTCATTAATCAGAAAACTGGTGAAATTAATATAACATCCATAGTTGATCGAGAGGTCACTCCTTTCTTCATTATCTACTGCCGA
GCTCTGAACTCAATGGGCCAAGATTTAGAGAGGCCTCTAGAGCTCAGAGTCAGGGTTTTGGATATAAATGACAACCCTCCAGTGTTTTCA
ATGGCTACATTTGCAGGACAAATAGAAGAAAATTCTAATGCAAATACACTGGTGATGATACTCAATGCTACTGACGCAGATGAACCGAAC
AATTTGAACTCAAAAATAGCCTTCAAGATTATAAGACAAGAACCTTCAGATTCACCAATGTTTATTATCAACAGAAATACTGGAGAAATT
CGAACGATGAATAATTTTCTAGACAGAGAGCAATACGGCCAGTATGCTCTTGCTGTAAGAGGCTCTGACCGAGATGGCGGGGCAGATGGC
ATGTCAGCGGAATGTGAGTGCAACATTAAAATCCTCGATGTCAATGATAATATCCCTTACATGGAACAGTCTTCATATACCATAGAAATT
CAAGAAAATACTCTAAATTCAAATTTGCTCGAGATTAGAGTAATTGATTTGGATGAAGAGTTCTCAGCTAACTGGATGGCAGTAATTTTC
TTTATCTCTGGAAATGAAGGAAATTGGTTTGAGATAGAAATGAATGAAAGAACAAATGTGGGAATTTTAAAGGTTGTTAAGCCCTTAGAT
TATGAAGCTATGCAGAGTCTGCAACTCAGTATTGGTGTCAGAAATAAAGCTGAATTTCATCATTCAATTATGTCTCAATATAAACTGAAA
GCATCTGCAATTTCTGTGACTGTGTTAAATGTAATTGAAGGCCCAGTGTTTCGTCCAGGTTCAAAGACATATGTTGTAACTGGTAATATG
GGATCAAATGATAAAGTGGGAGACTTTGTAGCTACTGACCTGGACACAGGTAGACCTTCAACGACTGTTAGGTATGTAATGGGAAATAAT
CCAGCTGACCTGCTAGCTGTTGATTCAAGAACAGGCAAACTCACTTTGAAAAATAAAGTTACCAAGGAACAGTACAATATGCTCGGAGGA
AAATACCAAGGAACGATTCTCTCTATAGATGATAATCTTCAAAGAACTTGCACTGGTACAATTAATATTAACATTCAAAGTTTTGGTAAT
GACGACAGGACTAATACAGAGCCGAACACTAAAATTACTACCAATACTGGCAGACAAGAAAGTACTTCTTCCACTAACTATGATACCAGC
ACAACTTCTACTGACTCTAGCCAAGTATATTCTTCTGAACCCGGAAACGGAGCCAAAGATTTGTTATCAGACAATGTACATTTTGGTCCT
GCTGGCATTGGACTCCTCATCATGGGATTCTTGGTCTTAGGATTGGTCCCATTTTTGATGATCTGTTGTGATTGTGGAGGTGCTCCTCGT
AGTGCAGCTGGCTTTGAGCCTGTTCCCGAATGTTCAGATGGAGCAATTCATTCATGGGCAGTAGAAGGACCACAGCCTGAACCCAGGGAT
ATAACCACTGTCATACCACAAATACCACCTGATAACGCAAATATAATTGAATGCATTGACAACTCAGGAGTTTATACAAATGAGTATGGT
GGCAGAGAAATGCAAGATCTGGGAGGAGGAGAGAGAATGACAGGATTTGAACTAACAGAGGGAGTTAAAACTTCAGGAATGCCTGAGATA
TGTCAAGAATACTCTGGAACATTAAGAAGAAATTCTATGAGGGAATGTAGAGAAGGAGGTCTGAATATGAATTTCATGGAAAGCTACTTC
TGTCAGAAAGCATATGCTTACGCAGATGAAGATGAAGGACGCCCATCTAATGACTGTTTGCTCATATATGACATCGAAGGTGTAGGTTCC
CCTGCTGGCTCTGTGGGTTGTTGTAGCTTCATTGGAGAAGACCTGGATGACAGCTTCTTGGATACCCTGGGACCTAAATTTAAGAAGTTG
GCAGACATCAGCCTAGGAAAAGAATCATATCCAGACCTTGATCCTTCTTGGCCACCACAAAGCACTGAACCAGTTTGCCTTCCTCAGGAA
ACAGAGCCCGTTGTTAGTGGACACCCACCAATCTCCCCACATTTCGGCACTACCACAGTAATTTCTGAGAGCACCTATCCCTCGGGACCT
GGTGTACTGCATCCTAAGCCTATTCTCGATCCTCTGGGCTATGGTAATGTCACTGTGACCGAGTCTTACACCACCTCTGACACTCTGAAG
CCCTCTGTGCACGTTCACGATAACCGACCAGCATCAAACGTGGTAGTGACAGAGAGAGTGGTCGGCCCAATCTCTGGCGCTGATTTGCAT
GGAATGTTAGAGATGCCTGACTTGCGAGATGGGTCGAATGTTATAGTGACAGAAAGGGTAATAGCACCAAGCTCTAGTCTACCCACCTCT
CTGACTATCCATCATCCTAGAGAGTCTTCAAATGTGGTAGTGACAGAAAGAGTAATCCAACCAACTTCCGGCATGATAGGTAGTCTGAGT
ATGCACCCCGAGTTAGCCAATGCCCACAATGTCATTGTGACAGAGAGGGTTGTTTCTGGTGCTGGCGTAACTGGAATTAGTGGCACCACT
GGGATCAGCGGTGGCATAGGCAGCAGTGGCCTGGTTGGCACCAGCATGGGTGCTGGGAGCGGTGCCCTGAGTGGAGCTGGCATAAGTGGT
GGTGGCATTGGCCTGAGCAGCTTGGGAGGGACAGCCAGCATTGGCCACATGAGGAGTTCCTCTGACCATCACTTTAACCAAACCATTGGG
TCCGCCTCCCCTAGCACAGCTCGAAGTCGAATCACAAAGTATAGTACCGTGCAATATAGCAAGTAGTCAGGACCCCAGCTCACTTTTTCA
TAGTCATTGTGGTTTAGATCCAATTCCCACCACTAAAAAACCAACAATGTGATTTATAACGCACAACTTCGTGCTCAGGTCATCTAGGAG
CAAGGTGAGAAATCACAATGAGAAAAATAAATGGAAACACCACTGCTAGGGGAGAGCTCTCCTTAGCATTCATAAACTTTTCTCTTATAT
TAGGACTAAGGAACTAAAACTTGAGGCAGAGTCTTCTTTGTGCCTGAGTGGCCTGTAGTCCATCTCCAGCATGTAACTGGCCTTACGATG
GCAATTGGCATCATTCTCCTTGCTCTGTTTTGCTTTTCCATATAGCTCGAGCAAAATTCAAAAAGAACTAAATATGCAATATATGTTCAT
ATCTATGGGAAAAATCTAAAATGTGTGCCAGATGCCCTGTTGGTTTCACAGATAACATAAATAAAAATTCAACCACAGATTTATACAAGG
GTTAACCATTTTTTTTAAGTTTGACTACATAGTCAAGTCCACAAGCCATCAAGCACTCCTACCTTAATTATTGCACTAGAGAAAATAAAT
TCCAAATTAGGAAGTGTTTCCTAGGAGGAAAATTCCATTAGAGAGTGGCAATAGGATGAGGTTTCTTCAGGGTAAACTAGCAATGCCTGA
GCCTGAACCTTAATGTGGGGCCTCAGTTAAATCTCCTGTGGAGTCAAGGATTCTTCTGATTCTAGTGTGTGTTTAGTGATAGATGTAGTC
TTGACGAATATTGCTTACTGGTGAGGTTGAGGAATATCACACTCGTCTTTCCCTTTACCACTGTGGTTTTGACTTAAGAAAGCAAAACTC
ACTAAGTTTACTTCTCGAATTGAAGCAAGTGAGGCCTGACATGGTTGTCATCACTAGTGGCAAATGACCTTCCAAGTAAGCAGATGGGAA
CTGAATTGTGTTTTCAGGTTTTGTTTTTAGTAGGTGATATTCATTCGTATCCAGCTCTTTATTACATAGCTCTGAAGTTAAAATGATTTA
CATAGGCCGAGCTGTGGACAAAAAAAAAAGAAGCAGCAGCTTGTAGTATGCTTAAGCTTTGGGGAATTTTTTTTTAAGGGGATCTAAAAA
AATGTTTTTAGAACATGTAAAATGTTTAATGGTGAAAGTTGGAAAAGAATTCTTCTGTAAAGTAATACCATGCTAATTATTCGCTTTTAG
TAAGTAAAGTAGTGGTTGCTTTAGCAAACCTCTGCTGCCATTTTGCAGGAATCAACCAGGAACCTTTAGCAGAATTGACAATATGGTGTT
GATAAGCATGAAATAATAATAGAAACCTATTCTGCTAGTTTATCTCACCCTCTAATTTTTCTCACTAGCATAAATTTTAAATTCCTGATT
TGATTTGTCAATAAGATCTTGGCTTATATATGCTGATTTATAGGTAGTGTCCAAATTATATAGTATAACATATTTTTCTAGTTTCAAAAT
TTAGTAATGTCCTATTTATGATATATCATTTCTGTGTGTTTGCTATGTAGTATTACCCAATTAAAAATCTCTAAAAAGAATTAAAGCATT
CTAAGAAAAAGGTAAATTTACTATTGCATGGTACAGAAATTTTTTCTTTCTTAAATACAATGTTACTATAAGCTCACTAAAATGAAACTC

>93317_93317_2_TPGS2-DSG1_TPGS2_chr18_34398857_ENST00000383056_DSG1_chr18_28906544_ENST00000257192_length(amino acids)=1129AA_BP=95
MRRAFRRRELPFPACHEIGLGAEAGSGPPPAPAARESRSRAMEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHM
ISSWEQVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIF
VINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNL
NSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQE
NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKAS
AISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKY
QGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAG
IGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGR
EMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPA
GSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGV
LHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLT
IHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGG

--------------------------------------------------------------
>93317_93317_3_TPGS2-DSG1_TPGS2_chr18_34398857_ENST00000587129_DSG1_chr18_28906544_ENST00000257192_length(transcript)=4987nt_BP=202nt
ACCCGCTCCCGCCGCGCGCGAATCGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGA
GAAGCTGACCCTGGGCATCACGCGCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCA
TATGATTTCTTCCTGGGAACAAGTGGTGGTAGAAGTTAACAGTGAATTCCGAATCCAGGTAAGAGATTATAACACTAAAAATGGCACCAT
CAAATGGCATTCAATCCGAAGGCAGAAACGTGAATGGATCAAGTTCGCAGCAGCCTGTCGTGAAGGTGAAGACAACTCAAAGAGGAACCC
AATCGCCAAAATTCACTCAGATTGTGCTGCAAACCAGCAAGTTACATACCGCATCTCTGGAGTAGGAATTGATCAGCCACCATATGGGAT
CTTTGTCATTAATCAGAAAACTGGTGAAATTAATATAACATCCATAGTTGATCGAGAGGTCACTCCTTTCTTCATTATCTACTGCCGAGC
TCTGAACTCAATGGGCCAAGATTTAGAGAGGCCTCTAGAGCTCAGAGTCAGGGTTTTGGATATAAATGACAACCCTCCAGTGTTTTCAAT
GGCTACATTTGCAGGACAAATAGAAGAAAATTCTAATGCAAATACACTGGTGATGATACTCAATGCTACTGACGCAGATGAACCGAACAA
TTTGAACTCAAAAATAGCCTTCAAGATTATAAGACAAGAACCTTCAGATTCACCAATGTTTATTATCAACAGAAATACTGGAGAAATTCG
AACGATGAATAATTTTCTAGACAGAGAGCAATACGGCCAGTATGCTCTTGCTGTAAGAGGCTCTGACCGAGATGGCGGGGCAGATGGCAT
GTCAGCGGAATGTGAGTGCAACATTAAAATCCTCGATGTCAATGATAATATCCCTTACATGGAACAGTCTTCATATACCATAGAAATTCA
AGAAAATACTCTAAATTCAAATTTGCTCGAGATTAGAGTAATTGATTTGGATGAAGAGTTCTCAGCTAACTGGATGGCAGTAATTTTCTT
TATCTCTGGAAATGAAGGAAATTGGTTTGAGATAGAAATGAATGAAAGAACAAATGTGGGAATTTTAAAGGTTGTTAAGCCCTTAGATTA
TGAAGCTATGCAGAGTCTGCAACTCAGTATTGGTGTCAGAAATAAAGCTGAATTTCATCATTCAATTATGTCTCAATATAAACTGAAAGC
ATCTGCAATTTCTGTGACTGTGTTAAATGTAATTGAAGGCCCAGTGTTTCGTCCAGGTTCAAAGACATATGTTGTAACTGGTAATATGGG
ATCAAATGATAAAGTGGGAGACTTTGTAGCTACTGACCTGGACACAGGTAGACCTTCAACGACTGTTAGGTATGTAATGGGAAATAATCC
AGCTGACCTGCTAGCTGTTGATTCAAGAACAGGCAAACTCACTTTGAAAAATAAAGTTACCAAGGAACAGTACAATATGCTCGGAGGAAA
ATACCAAGGAACGATTCTCTCTATAGATGATAATCTTCAAAGAACTTGCACTGGTACAATTAATATTAACATTCAAAGTTTTGGTAATGA
CGACAGGACTAATACAGAGCCGAACACTAAAATTACTACCAATACTGGCAGACAAGAAAGTACTTCTTCCACTAACTATGATACCAGCAC
AACTTCTACTGACTCTAGCCAAGTATATTCTTCTGAACCCGGAAACGGAGCCAAAGATTTGTTATCAGACAATGTACATTTTGGTCCTGC
TGGCATTGGACTCCTCATCATGGGATTCTTGGTCTTAGGATTGGTCCCATTTTTGATGATCTGTTGTGATTGTGGAGGTGCTCCTCGTAG
TGCAGCTGGCTTTGAGCCTGTTCCCGAATGTTCAGATGGAGCAATTCATTCATGGGCAGTAGAAGGACCACAGCCTGAACCCAGGGATAT
AACCACTGTCATACCACAAATACCACCTGATAACGCAAATATAATTGAATGCATTGACAACTCAGGAGTTTATACAAATGAGTATGGTGG
CAGAGAAATGCAAGATCTGGGAGGAGGAGAGAGAATGACAGGATTTGAACTAACAGAGGGAGTTAAAACTTCAGGAATGCCTGAGATATG
TCAAGAATACTCTGGAACATTAAGAAGAAATTCTATGAGGGAATGTAGAGAAGGAGGTCTGAATATGAATTTCATGGAAAGCTACTTCTG
TCAGAAAGCATATGCTTACGCAGATGAAGATGAAGGACGCCCATCTAATGACTGTTTGCTCATATATGACATCGAAGGTGTAGGTTCCCC
TGCTGGCTCTGTGGGTTGTTGTAGCTTCATTGGAGAAGACCTGGATGACAGCTTCTTGGATACCCTGGGACCTAAATTTAAGAAGTTGGC
AGACATCAGCCTAGGAAAAGAATCATATCCAGACCTTGATCCTTCTTGGCCACCACAAAGCACTGAACCAGTTTGCCTTCCTCAGGAAAC
AGAGCCCGTTGTTAGTGGACACCCACCAATCTCCCCACATTTCGGCACTACCACAGTAATTTCTGAGAGCACCTATCCCTCGGGACCTGG
TGTACTGCATCCTAAGCCTATTCTCGATCCTCTGGGCTATGGTAATGTCACTGTGACCGAGTCTTACACCACCTCTGACACTCTGAAGCC
CTCTGTGCACGTTCACGATAACCGACCAGCATCAAACGTGGTAGTGACAGAGAGAGTGGTCGGCCCAATCTCTGGCGCTGATTTGCATGG
AATGTTAGAGATGCCTGACTTGCGAGATGGGTCGAATGTTATAGTGACAGAAAGGGTAATAGCACCAAGCTCTAGTCTACCCACCTCTCT
GACTATCCATCATCCTAGAGAGTCTTCAAATGTGGTAGTGACAGAAAGAGTAATCCAACCAACTTCCGGCATGATAGGTAGTCTGAGTAT
GCACCCCGAGTTAGCCAATGCCCACAATGTCATTGTGACAGAGAGGGTTGTTTCTGGTGCTGGCGTAACTGGAATTAGTGGCACCACTGG
GATCAGCGGTGGCATAGGCAGCAGTGGCCTGGTTGGCACCAGCATGGGTGCTGGGAGCGGTGCCCTGAGTGGAGCTGGCATAAGTGGTGG
TGGCATTGGCCTGAGCAGCTTGGGAGGGACAGCCAGCATTGGCCACATGAGGAGTTCCTCTGACCATCACTTTAACCAAACCATTGGGTC
CGCCTCCCCTAGCACAGCTCGAAGTCGAATCACAAAGTATAGTACCGTGCAATATAGCAAGTAGTCAGGACCCCAGCTCACTTTTTCATA
GTCATTGTGGTTTAGATCCAATTCCCACCACTAAAAAACCAACAATGTGATTTATAACGCACAACTTCGTGCTCAGGTCATCTAGGAGCA
AGGTGAGAAATCACAATGAGAAAAATAAATGGAAACACCACTGCTAGGGGAGAGCTCTCCTTAGCATTCATAAACTTTTCTCTTATATTA
GGACTAAGGAACTAAAACTTGAGGCAGAGTCTTCTTTGTGCCTGAGTGGCCTGTAGTCCATCTCCAGCATGTAACTGGCCTTACGATGGC
AATTGGCATCATTCTCCTTGCTCTGTTTTGCTTTTCCATATAGCTCGAGCAAAATTCAAAAAGAACTAAATATGCAATATATGTTCATAT
CTATGGGAAAAATCTAAAATGTGTGCCAGATGCCCTGTTGGTTTCACAGATAACATAAATAAAAATTCAACCACAGATTTATACAAGGGT
TAACCATTTTTTTTAAGTTTGACTACATAGTCAAGTCCACAAGCCATCAAGCACTCCTACCTTAATTATTGCACTAGAGAAAATAAATTC
CAAATTAGGAAGTGTTTCCTAGGAGGAAAATTCCATTAGAGAGTGGCAATAGGATGAGGTTTCTTCAGGGTAAACTAGCAATGCCTGAGC
CTGAACCTTAATGTGGGGCCTCAGTTAAATCTCCTGTGGAGTCAAGGATTCTTCTGATTCTAGTGTGTGTTTAGTGATAGATGTAGTCTT
GACGAATATTGCTTACTGGTGAGGTTGAGGAATATCACACTCGTCTTTCCCTTTACCACTGTGGTTTTGACTTAAGAAAGCAAAACTCAC
TAAGTTTACTTCTCGAATTGAAGCAAGTGAGGCCTGACATGGTTGTCATCACTAGTGGCAAATGACCTTCCAAGTAAGCAGATGGGAACT
GAATTGTGTTTTCAGGTTTTGTTTTTAGTAGGTGATATTCATTCGTATCCAGCTCTTTATTACATAGCTCTGAAGTTAAAATGATTTACA
TAGGCCGAGCTGTGGACAAAAAAAAAAGAAGCAGCAGCTTGTAGTATGCTTAAGCTTTGGGGAATTTTTTTTTAAGGGGATCTAAAAAAA
TGTTTTTAGAACATGTAAAATGTTTAATGGTGAAAGTTGGAAAAGAATTCTTCTGTAAAGTAATACCATGCTAATTATTCGCTTTTAGTA
AGTAAAGTAGTGGTTGCTTTAGCAAACCTCTGCTGCCATTTTGCAGGAATCAACCAGGAACCTTTAGCAGAATTGACAATATGGTGTTGA
TAAGCATGAAATAATAATAGAAACCTATTCTGCTAGTTTATCTCACCCTCTAATTTTTCTCACTAGCATAAATTTTAAATTCCTGATTTG
ATTTGTCAATAAGATCTTGGCTTATATATGCTGATTTATAGGTAGTGTCCAAATTATATAGTATAACATATTTTTCTAGTTTCAAAATTT
AGTAATGTCCTATTTATGATATATCATTTCTGTGTGTTTGCTATGTAGTATTACCCAATTAAAAATCTCTAAAAAGAATTAAAGCATTCT
AAGAAAAAGGTAAATTTACTATTGCATGGTACAGAAATTTTTTCTTTCTTAAATACAATGTTACTATAAGCTCACTAAAATGAAACTCTA

>93317_93317_3_TPGS2-DSG1_TPGS2_chr18_34398857_ENST00000587129_DSG1_chr18_28906544_ENST00000257192_length(amino acids)=1088AA_BP=54
MEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHMISSWEQVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREW
IKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPL
ELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYG
QYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIE
MNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATD
LDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKIT
TNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSD
GAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSM
RECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDL
DPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDNRPASN
VVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIV
TERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITK

--------------------------------------------------------------
>93317_93317_4_TPGS2-DSG1_TPGS2_chr18_34398857_ENST00000589049_DSG1_chr18_28906544_ENST00000257192_length(transcript)=4964nt_BP=179nt
CGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCACGC
GCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACAAG
TGGTGGTAGAAGTTAACAGTGAATTCCGAATCCAGGTAAGAGATTATAACACTAAAAATGGCACCATCAAATGGCATTCAATCCGAAGGC
AGAAACGTGAATGGATCAAGTTCGCAGCAGCCTGTCGTGAAGGTGAAGACAACTCAAAGAGGAACCCAATCGCCAAAATTCACTCAGATT
GTGCTGCAAACCAGCAAGTTACATACCGCATCTCTGGAGTAGGAATTGATCAGCCACCATATGGGATCTTTGTCATTAATCAGAAAACTG
GTGAAATTAATATAACATCCATAGTTGATCGAGAGGTCACTCCTTTCTTCATTATCTACTGCCGAGCTCTGAACTCAATGGGCCAAGATT
TAGAGAGGCCTCTAGAGCTCAGAGTCAGGGTTTTGGATATAAATGACAACCCTCCAGTGTTTTCAATGGCTACATTTGCAGGACAAATAG
AAGAAAATTCTAATGCAAATACACTGGTGATGATACTCAATGCTACTGACGCAGATGAACCGAACAATTTGAACTCAAAAATAGCCTTCA
AGATTATAAGACAAGAACCTTCAGATTCACCAATGTTTATTATCAACAGAAATACTGGAGAAATTCGAACGATGAATAATTTTCTAGACA
GAGAGCAATACGGCCAGTATGCTCTTGCTGTAAGAGGCTCTGACCGAGATGGCGGGGCAGATGGCATGTCAGCGGAATGTGAGTGCAACA
TTAAAATCCTCGATGTCAATGATAATATCCCTTACATGGAACAGTCTTCATATACCATAGAAATTCAAGAAAATACTCTAAATTCAAATT
TGCTCGAGATTAGAGTAATTGATTTGGATGAAGAGTTCTCAGCTAACTGGATGGCAGTAATTTTCTTTATCTCTGGAAATGAAGGAAATT
GGTTTGAGATAGAAATGAATGAAAGAACAAATGTGGGAATTTTAAAGGTTGTTAAGCCCTTAGATTATGAAGCTATGCAGAGTCTGCAAC
TCAGTATTGGTGTCAGAAATAAAGCTGAATTTCATCATTCAATTATGTCTCAATATAAACTGAAAGCATCTGCAATTTCTGTGACTGTGT
TAAATGTAATTGAAGGCCCAGTGTTTCGTCCAGGTTCAAAGACATATGTTGTAACTGGTAATATGGGATCAAATGATAAAGTGGGAGACT
TTGTAGCTACTGACCTGGACACAGGTAGACCTTCAACGACTGTTAGGTATGTAATGGGAAATAATCCAGCTGACCTGCTAGCTGTTGATT
CAAGAACAGGCAAACTCACTTTGAAAAATAAAGTTACCAAGGAACAGTACAATATGCTCGGAGGAAAATACCAAGGAACGATTCTCTCTA
TAGATGATAATCTTCAAAGAACTTGCACTGGTACAATTAATATTAACATTCAAAGTTTTGGTAATGACGACAGGACTAATACAGAGCCGA
ACACTAAAATTACTACCAATACTGGCAGACAAGAAAGTACTTCTTCCACTAACTATGATACCAGCACAACTTCTACTGACTCTAGCCAAG
TATATTCTTCTGAACCCGGAAACGGAGCCAAAGATTTGTTATCAGACAATGTACATTTTGGTCCTGCTGGCATTGGACTCCTCATCATGG
GATTCTTGGTCTTAGGATTGGTCCCATTTTTGATGATCTGTTGTGATTGTGGAGGTGCTCCTCGTAGTGCAGCTGGCTTTGAGCCTGTTC
CCGAATGTTCAGATGGAGCAATTCATTCATGGGCAGTAGAAGGACCACAGCCTGAACCCAGGGATATAACCACTGTCATACCACAAATAC
CACCTGATAACGCAAATATAATTGAATGCATTGACAACTCAGGAGTTTATACAAATGAGTATGGTGGCAGAGAAATGCAAGATCTGGGAG
GAGGAGAGAGAATGACAGGATTTGAACTAACAGAGGGAGTTAAAACTTCAGGAATGCCTGAGATATGTCAAGAATACTCTGGAACATTAA
GAAGAAATTCTATGAGGGAATGTAGAGAAGGAGGTCTGAATATGAATTTCATGGAAAGCTACTTCTGTCAGAAAGCATATGCTTACGCAG
ATGAAGATGAAGGACGCCCATCTAATGACTGTTTGCTCATATATGACATCGAAGGTGTAGGTTCCCCTGCTGGCTCTGTGGGTTGTTGTA
GCTTCATTGGAGAAGACCTGGATGACAGCTTCTTGGATACCCTGGGACCTAAATTTAAGAAGTTGGCAGACATCAGCCTAGGAAAAGAAT
CATATCCAGACCTTGATCCTTCTTGGCCACCACAAAGCACTGAACCAGTTTGCCTTCCTCAGGAAACAGAGCCCGTTGTTAGTGGACACC
CACCAATCTCCCCACATTTCGGCACTACCACAGTAATTTCTGAGAGCACCTATCCCTCGGGACCTGGTGTACTGCATCCTAAGCCTATTC
TCGATCCTCTGGGCTATGGTAATGTCACTGTGACCGAGTCTTACACCACCTCTGACACTCTGAAGCCCTCTGTGCACGTTCACGATAACC
GACCAGCATCAAACGTGGTAGTGACAGAGAGAGTGGTCGGCCCAATCTCTGGCGCTGATTTGCATGGAATGTTAGAGATGCCTGACTTGC
GAGATGGGTCGAATGTTATAGTGACAGAAAGGGTAATAGCACCAAGCTCTAGTCTACCCACCTCTCTGACTATCCATCATCCTAGAGAGT
CTTCAAATGTGGTAGTGACAGAAAGAGTAATCCAACCAACTTCCGGCATGATAGGTAGTCTGAGTATGCACCCCGAGTTAGCCAATGCCC
ACAATGTCATTGTGACAGAGAGGGTTGTTTCTGGTGCTGGCGTAACTGGAATTAGTGGCACCACTGGGATCAGCGGTGGCATAGGCAGCA
GTGGCCTGGTTGGCACCAGCATGGGTGCTGGGAGCGGTGCCCTGAGTGGAGCTGGCATAAGTGGTGGTGGCATTGGCCTGAGCAGCTTGG
GAGGGACAGCCAGCATTGGCCACATGAGGAGTTCCTCTGACCATCACTTTAACCAAACCATTGGGTCCGCCTCCCCTAGCACAGCTCGAA
GTCGAATCACAAAGTATAGTACCGTGCAATATAGCAAGTAGTCAGGACCCCAGCTCACTTTTTCATAGTCATTGTGGTTTAGATCCAATT
CCCACCACTAAAAAACCAACAATGTGATTTATAACGCACAACTTCGTGCTCAGGTCATCTAGGAGCAAGGTGAGAAATCACAATGAGAAA
AATAAATGGAAACACCACTGCTAGGGGAGAGCTCTCCTTAGCATTCATAAACTTTTCTCTTATATTAGGACTAAGGAACTAAAACTTGAG
GCAGAGTCTTCTTTGTGCCTGAGTGGCCTGTAGTCCATCTCCAGCATGTAACTGGCCTTACGATGGCAATTGGCATCATTCTCCTTGCTC
TGTTTTGCTTTTCCATATAGCTCGAGCAAAATTCAAAAAGAACTAAATATGCAATATATGTTCATATCTATGGGAAAAATCTAAAATGTG
TGCCAGATGCCCTGTTGGTTTCACAGATAACATAAATAAAAATTCAACCACAGATTTATACAAGGGTTAACCATTTTTTTTAAGTTTGAC
TACATAGTCAAGTCCACAAGCCATCAAGCACTCCTACCTTAATTATTGCACTAGAGAAAATAAATTCCAAATTAGGAAGTGTTTCCTAGG
AGGAAAATTCCATTAGAGAGTGGCAATAGGATGAGGTTTCTTCAGGGTAAACTAGCAATGCCTGAGCCTGAACCTTAATGTGGGGCCTCA
GTTAAATCTCCTGTGGAGTCAAGGATTCTTCTGATTCTAGTGTGTGTTTAGTGATAGATGTAGTCTTGACGAATATTGCTTACTGGTGAG
GTTGAGGAATATCACACTCGTCTTTCCCTTTACCACTGTGGTTTTGACTTAAGAAAGCAAAACTCACTAAGTTTACTTCTCGAATTGAAG
CAAGTGAGGCCTGACATGGTTGTCATCACTAGTGGCAAATGACCTTCCAAGTAAGCAGATGGGAACTGAATTGTGTTTTCAGGTTTTGTT
TTTAGTAGGTGATATTCATTCGTATCCAGCTCTTTATTACATAGCTCTGAAGTTAAAATGATTTACATAGGCCGAGCTGTGGACAAAAAA
AAAAGAAGCAGCAGCTTGTAGTATGCTTAAGCTTTGGGGAATTTTTTTTTAAGGGGATCTAAAAAAATGTTTTTAGAACATGTAAAATGT
TTAATGGTGAAAGTTGGAAAAGAATTCTTCTGTAAAGTAATACCATGCTAATTATTCGCTTTTAGTAAGTAAAGTAGTGGTTGCTTTAGC
AAACCTCTGCTGCCATTTTGCAGGAATCAACCAGGAACCTTTAGCAGAATTGACAATATGGTGTTGATAAGCATGAAATAATAATAGAAA
CCTATTCTGCTAGTTTATCTCACCCTCTAATTTTTCTCACTAGCATAAATTTTAAATTCCTGATTTGATTTGTCAATAAGATCTTGGCTT
ATATATGCTGATTTATAGGTAGTGTCCAAATTATATAGTATAACATATTTTTCTAGTTTCAAAATTTAGTAATGTCCTATTTATGATATA
TCATTTCTGTGTGTTTGCTATGTAGTATTACCCAATTAAAAATCTCTAAAAAGAATTAAAGCATTCTAAGAAAAAGGTAAATTTACTATT
GCATGGTACAGAAATTTTTTCTTTCTTAAATACAATGTTACTATAAGCTCACTAAAATGAAACTCTATATGACAAAATAAAATTAGAAAA

>93317_93317_4_TPGS2-DSG1_TPGS2_chr18_34398857_ENST00000589049_DSG1_chr18_28906544_ENST00000257192_length(amino acids)=1088AA_BP=54
MEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHMISSWEQVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREW
IKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPL
ELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYG
QYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIE
MNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATD
LDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKIT
TNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSD
GAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSM
RECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDL
DPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDNRPASN
VVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIV
TERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITK

--------------------------------------------------------------
>93317_93317_5_TPGS2-DSG1_TPGS2_chr18_34398857_ENST00000590842_DSG1_chr18_28906544_ENST00000257192_length(transcript)=5025nt_BP=240nt
GAAATTGGCCTCGGCGCTGAGGCGGGGTCCGGCCCTCCACCCGCTCCCGCCGCGCGCGAATCGCGGTCGCGAGCCATGGAGGAGGAGGCA
TCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCACGCGCATCCTAGAATCTTCCCCAGGTGTGACT
GAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACAAGTGGTGGTAGAAGTTAACAGTGAATTCCGA
ATCCAGGTAAGAGATTATAACACTAAAAATGGCACCATCAAATGGCATTCAATCCGAAGGCAGAAACGTGAATGGATCAAGTTCGCAGCA
GCCTGTCGTGAAGGTGAAGACAACTCAAAGAGGAACCCAATCGCCAAAATTCACTCAGATTGTGCTGCAAACCAGCAAGTTACATACCGC
ATCTCTGGAGTAGGAATTGATCAGCCACCATATGGGATCTTTGTCATTAATCAGAAAACTGGTGAAATTAATATAACATCCATAGTTGAT
CGAGAGGTCACTCCTTTCTTCATTATCTACTGCCGAGCTCTGAACTCAATGGGCCAAGATTTAGAGAGGCCTCTAGAGCTCAGAGTCAGG
GTTTTGGATATAAATGACAACCCTCCAGTGTTTTCAATGGCTACATTTGCAGGACAAATAGAAGAAAATTCTAATGCAAATACACTGGTG
ATGATACTCAATGCTACTGACGCAGATGAACCGAACAATTTGAACTCAAAAATAGCCTTCAAGATTATAAGACAAGAACCTTCAGATTCA
CCAATGTTTATTATCAACAGAAATACTGGAGAAATTCGAACGATGAATAATTTTCTAGACAGAGAGCAATACGGCCAGTATGCTCTTGCT
GTAAGAGGCTCTGACCGAGATGGCGGGGCAGATGGCATGTCAGCGGAATGTGAGTGCAACATTAAAATCCTCGATGTCAATGATAATATC
CCTTACATGGAACAGTCTTCATATACCATAGAAATTCAAGAAAATACTCTAAATTCAAATTTGCTCGAGATTAGAGTAATTGATTTGGAT
GAAGAGTTCTCAGCTAACTGGATGGCAGTAATTTTCTTTATCTCTGGAAATGAAGGAAATTGGTTTGAGATAGAAATGAATGAAAGAACA
AATGTGGGAATTTTAAAGGTTGTTAAGCCCTTAGATTATGAAGCTATGCAGAGTCTGCAACTCAGTATTGGTGTCAGAAATAAAGCTGAA
TTTCATCATTCAATTATGTCTCAATATAAACTGAAAGCATCTGCAATTTCTGTGACTGTGTTAAATGTAATTGAAGGCCCAGTGTTTCGT
CCAGGTTCAAAGACATATGTTGTAACTGGTAATATGGGATCAAATGATAAAGTGGGAGACTTTGTAGCTACTGACCTGGACACAGGTAGA
CCTTCAACGACTGTTAGGTATGTAATGGGAAATAATCCAGCTGACCTGCTAGCTGTTGATTCAAGAACAGGCAAACTCACTTTGAAAAAT
AAAGTTACCAAGGAACAGTACAATATGCTCGGAGGAAAATACCAAGGAACGATTCTCTCTATAGATGATAATCTTCAAAGAACTTGCACT
GGTACAATTAATATTAACATTCAAAGTTTTGGTAATGACGACAGGACTAATACAGAGCCGAACACTAAAATTACTACCAATACTGGCAGA
CAAGAAAGTACTTCTTCCACTAACTATGATACCAGCACAACTTCTACTGACTCTAGCCAAGTATATTCTTCTGAACCCGGAAACGGAGCC
AAAGATTTGTTATCAGACAATGTACATTTTGGTCCTGCTGGCATTGGACTCCTCATCATGGGATTCTTGGTCTTAGGATTGGTCCCATTT
TTGATGATCTGTTGTGATTGTGGAGGTGCTCCTCGTAGTGCAGCTGGCTTTGAGCCTGTTCCCGAATGTTCAGATGGAGCAATTCATTCA
TGGGCAGTAGAAGGACCACAGCCTGAACCCAGGGATATAACCACTGTCATACCACAAATACCACCTGATAACGCAAATATAATTGAATGC
ATTGACAACTCAGGAGTTTATACAAATGAGTATGGTGGCAGAGAAATGCAAGATCTGGGAGGAGGAGAGAGAATGACAGGATTTGAACTA
ACAGAGGGAGTTAAAACTTCAGGAATGCCTGAGATATGTCAAGAATACTCTGGAACATTAAGAAGAAATTCTATGAGGGAATGTAGAGAA
GGAGGTCTGAATATGAATTTCATGGAAAGCTACTTCTGTCAGAAAGCATATGCTTACGCAGATGAAGATGAAGGACGCCCATCTAATGAC
TGTTTGCTCATATATGACATCGAAGGTGTAGGTTCCCCTGCTGGCTCTGTGGGTTGTTGTAGCTTCATTGGAGAAGACCTGGATGACAGC
TTCTTGGATACCCTGGGACCTAAATTTAAGAAGTTGGCAGACATCAGCCTAGGAAAAGAATCATATCCAGACCTTGATCCTTCTTGGCCA
CCACAAAGCACTGAACCAGTTTGCCTTCCTCAGGAAACAGAGCCCGTTGTTAGTGGACACCCACCAATCTCCCCACATTTCGGCACTACC
ACAGTAATTTCTGAGAGCACCTATCCCTCGGGACCTGGTGTACTGCATCCTAAGCCTATTCTCGATCCTCTGGGCTATGGTAATGTCACT
GTGACCGAGTCTTACACCACCTCTGACACTCTGAAGCCCTCTGTGCACGTTCACGATAACCGACCAGCATCAAACGTGGTAGTGACAGAG
AGAGTGGTCGGCCCAATCTCTGGCGCTGATTTGCATGGAATGTTAGAGATGCCTGACTTGCGAGATGGGTCGAATGTTATAGTGACAGAA
AGGGTAATAGCACCAAGCTCTAGTCTACCCACCTCTCTGACTATCCATCATCCTAGAGAGTCTTCAAATGTGGTAGTGACAGAAAGAGTA
ATCCAACCAACTTCCGGCATGATAGGTAGTCTGAGTATGCACCCCGAGTTAGCCAATGCCCACAATGTCATTGTGACAGAGAGGGTTGTT
TCTGGTGCTGGCGTAACTGGAATTAGTGGCACCACTGGGATCAGCGGTGGCATAGGCAGCAGTGGCCTGGTTGGCACCAGCATGGGTGCT
GGGAGCGGTGCCCTGAGTGGAGCTGGCATAAGTGGTGGTGGCATTGGCCTGAGCAGCTTGGGAGGGACAGCCAGCATTGGCCACATGAGG
AGTTCCTCTGACCATCACTTTAACCAAACCATTGGGTCCGCCTCCCCTAGCACAGCTCGAAGTCGAATCACAAAGTATAGTACCGTGCAA
TATAGCAAGTAGTCAGGACCCCAGCTCACTTTTTCATAGTCATTGTGGTTTAGATCCAATTCCCACCACTAAAAAACCAACAATGTGATT
TATAACGCACAACTTCGTGCTCAGGTCATCTAGGAGCAAGGTGAGAAATCACAATGAGAAAAATAAATGGAAACACCACTGCTAGGGGAG
AGCTCTCCTTAGCATTCATAAACTTTTCTCTTATATTAGGACTAAGGAACTAAAACTTGAGGCAGAGTCTTCTTTGTGCCTGAGTGGCCT
GTAGTCCATCTCCAGCATGTAACTGGCCTTACGATGGCAATTGGCATCATTCTCCTTGCTCTGTTTTGCTTTTCCATATAGCTCGAGCAA
AATTCAAAAAGAACTAAATATGCAATATATGTTCATATCTATGGGAAAAATCTAAAATGTGTGCCAGATGCCCTGTTGGTTTCACAGATA
ACATAAATAAAAATTCAACCACAGATTTATACAAGGGTTAACCATTTTTTTTAAGTTTGACTACATAGTCAAGTCCACAAGCCATCAAGC
ACTCCTACCTTAATTATTGCACTAGAGAAAATAAATTCCAAATTAGGAAGTGTTTCCTAGGAGGAAAATTCCATTAGAGAGTGGCAATAG
GATGAGGTTTCTTCAGGGTAAACTAGCAATGCCTGAGCCTGAACCTTAATGTGGGGCCTCAGTTAAATCTCCTGTGGAGTCAAGGATTCT
TCTGATTCTAGTGTGTGTTTAGTGATAGATGTAGTCTTGACGAATATTGCTTACTGGTGAGGTTGAGGAATATCACACTCGTCTTTCCCT
TTACCACTGTGGTTTTGACTTAAGAAAGCAAAACTCACTAAGTTTACTTCTCGAATTGAAGCAAGTGAGGCCTGACATGGTTGTCATCAC
TAGTGGCAAATGACCTTCCAAGTAAGCAGATGGGAACTGAATTGTGTTTTCAGGTTTTGTTTTTAGTAGGTGATATTCATTCGTATCCAG
CTCTTTATTACATAGCTCTGAAGTTAAAATGATTTACATAGGCCGAGCTGTGGACAAAAAAAAAAGAAGCAGCAGCTTGTAGTATGCTTA
AGCTTTGGGGAATTTTTTTTTAAGGGGATCTAAAAAAATGTTTTTAGAACATGTAAAATGTTTAATGGTGAAAGTTGGAAAAGAATTCTT
CTGTAAAGTAATACCATGCTAATTATTCGCTTTTAGTAAGTAAAGTAGTGGTTGCTTTAGCAAACCTCTGCTGCCATTTTGCAGGAATCA
ACCAGGAACCTTTAGCAGAATTGACAATATGGTGTTGATAAGCATGAAATAATAATAGAAACCTATTCTGCTAGTTTATCTCACCCTCTA
ATTTTTCTCACTAGCATAAATTTTAAATTCCTGATTTGATTTGTCAATAAGATCTTGGCTTATATATGCTGATTTATAGGTAGTGTCCAA
ATTATATAGTATAACATATTTTTCTAGTTTCAAAATTTAGTAATGTCCTATTTATGATATATCATTTCTGTGTGTTTGCTATGTAGTATT
ACCCAATTAAAAATCTCTAAAAAGAATTAAAGCATTCTAAGAAAAAGGTAAATTTACTATTGCATGGTACAGAAATTTTTTCTTTCTTAA

>93317_93317_5_TPGS2-DSG1_TPGS2_chr18_34398857_ENST00000590842_DSG1_chr18_28906544_ENST00000257192_length(amino acids)=1088AA_BP=54
MEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHMISSWEQVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREW
IKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPL
ELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYG
QYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIE
MNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATD
LDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKIT
TNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSD
GAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSM
RECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDL
DPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDNRPASN
VVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIV
TERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITK

--------------------------------------------------------------
>93317_93317_6_TPGS2-DSG1_TPGS2_chr18_34398857_ENST00000593035_DSG1_chr18_28906544_ENST00000257192_length(transcript)=5146nt_BP=361nt
ACCGGGCGGGGCCGCGGGAACCGGCGCCCCACGGAGCTGCTGCTGTCAGACCAACCCCGGGCCCCCATCATCACTGCGCCGCGCTTTCAG
GCGCCGAGAACTACCGTTCCCGGCATGCCATGAAATTGGCCTCGGCGCTGAGGCGGGGTCCGGCCCTCCACCCGCTCCCGCCGCGCGCGA
ATCGCGGTCGCGAGCCATGGAGGAGGAGGCATCGTCCCCGGGGCTGGGCTGCAGCAAGCCGCACCTGGAGAAGCTGACCCTGGGCATCAC
GCGCATCCTAGAATCTTCCCCAGGTGTGACTGAGGTGACCATCATAGAAAAGCCTCCTGCTGAACGTCATATGATTTCTTCCTGGGAACA
AGTGGTGGTAGAAGTTAACAGTGAATTCCGAATCCAGGTAAGAGATTATAACACTAAAAATGGCACCATCAAATGGCATTCAATCCGAAG
GCAGAAACGTGAATGGATCAAGTTCGCAGCAGCCTGTCGTGAAGGTGAAGACAACTCAAAGAGGAACCCAATCGCCAAAATTCACTCAGA
TTGTGCTGCAAACCAGCAAGTTACATACCGCATCTCTGGAGTAGGAATTGATCAGCCACCATATGGGATCTTTGTCATTAATCAGAAAAC
TGGTGAAATTAATATAACATCCATAGTTGATCGAGAGGTCACTCCTTTCTTCATTATCTACTGCCGAGCTCTGAACTCAATGGGCCAAGA
TTTAGAGAGGCCTCTAGAGCTCAGAGTCAGGGTTTTGGATATAAATGACAACCCTCCAGTGTTTTCAATGGCTACATTTGCAGGACAAAT
AGAAGAAAATTCTAATGCAAATACACTGGTGATGATACTCAATGCTACTGACGCAGATGAACCGAACAATTTGAACTCAAAAATAGCCTT
CAAGATTATAAGACAAGAACCTTCAGATTCACCAATGTTTATTATCAACAGAAATACTGGAGAAATTCGAACGATGAATAATTTTCTAGA
CAGAGAGCAATACGGCCAGTATGCTCTTGCTGTAAGAGGCTCTGACCGAGATGGCGGGGCAGATGGCATGTCAGCGGAATGTGAGTGCAA
CATTAAAATCCTCGATGTCAATGATAATATCCCTTACATGGAACAGTCTTCATATACCATAGAAATTCAAGAAAATACTCTAAATTCAAA
TTTGCTCGAGATTAGAGTAATTGATTTGGATGAAGAGTTCTCAGCTAACTGGATGGCAGTAATTTTCTTTATCTCTGGAAATGAAGGAAA
TTGGTTTGAGATAGAAATGAATGAAAGAACAAATGTGGGAATTTTAAAGGTTGTTAAGCCCTTAGATTATGAAGCTATGCAGAGTCTGCA
ACTCAGTATTGGTGTCAGAAATAAAGCTGAATTTCATCATTCAATTATGTCTCAATATAAACTGAAAGCATCTGCAATTTCTGTGACTGT
GTTAAATGTAATTGAAGGCCCAGTGTTTCGTCCAGGTTCAAAGACATATGTTGTAACTGGTAATATGGGATCAAATGATAAAGTGGGAGA
CTTTGTAGCTACTGACCTGGACACAGGTAGACCTTCAACGACTGTTAGGTATGTAATGGGAAATAATCCAGCTGACCTGCTAGCTGTTGA
TTCAAGAACAGGCAAACTCACTTTGAAAAATAAAGTTACCAAGGAACAGTACAATATGCTCGGAGGAAAATACCAAGGAACGATTCTCTC
TATAGATGATAATCTTCAAAGAACTTGCACTGGTACAATTAATATTAACATTCAAAGTTTTGGTAATGACGACAGGACTAATACAGAGCC
GAACACTAAAATTACTACCAATACTGGCAGACAAGAAAGTACTTCTTCCACTAACTATGATACCAGCACAACTTCTACTGACTCTAGCCA
AGTATATTCTTCTGAACCCGGAAACGGAGCCAAAGATTTGTTATCAGACAATGTACATTTTGGTCCTGCTGGCATTGGACTCCTCATCAT
GGGATTCTTGGTCTTAGGATTGGTCCCATTTTTGATGATCTGTTGTGATTGTGGAGGTGCTCCTCGTAGTGCAGCTGGCTTTGAGCCTGT
TCCCGAATGTTCAGATGGAGCAATTCATTCATGGGCAGTAGAAGGACCACAGCCTGAACCCAGGGATATAACCACTGTCATACCACAAAT
ACCACCTGATAACGCAAATATAATTGAATGCATTGACAACTCAGGAGTTTATACAAATGAGTATGGTGGCAGAGAAATGCAAGATCTGGG
AGGAGGAGAGAGAATGACAGGATTTGAACTAACAGAGGGAGTTAAAACTTCAGGAATGCCTGAGATATGTCAAGAATACTCTGGAACATT
AAGAAGAAATTCTATGAGGGAATGTAGAGAAGGAGGTCTGAATATGAATTTCATGGAAAGCTACTTCTGTCAGAAAGCATATGCTTACGC
AGATGAAGATGAAGGACGCCCATCTAATGACTGTTTGCTCATATATGACATCGAAGGTGTAGGTTCCCCTGCTGGCTCTGTGGGTTGTTG
TAGCTTCATTGGAGAAGACCTGGATGACAGCTTCTTGGATACCCTGGGACCTAAATTTAAGAAGTTGGCAGACATCAGCCTAGGAAAAGA
ATCATATCCAGACCTTGATCCTTCTTGGCCACCACAAAGCACTGAACCAGTTTGCCTTCCTCAGGAAACAGAGCCCGTTGTTAGTGGACA
CCCACCAATCTCCCCACATTTCGGCACTACCACAGTAATTTCTGAGAGCACCTATCCCTCGGGACCTGGTGTACTGCATCCTAAGCCTAT
TCTCGATCCTCTGGGCTATGGTAATGTCACTGTGACCGAGTCTTACACCACCTCTGACACTCTGAAGCCCTCTGTGCACGTTCACGATAA
CCGACCAGCATCAAACGTGGTAGTGACAGAGAGAGTGGTCGGCCCAATCTCTGGCGCTGATTTGCATGGAATGTTAGAGATGCCTGACTT
GCGAGATGGGTCGAATGTTATAGTGACAGAAAGGGTAATAGCACCAAGCTCTAGTCTACCCACCTCTCTGACTATCCATCATCCTAGAGA
GTCTTCAAATGTGGTAGTGACAGAAAGAGTAATCCAACCAACTTCCGGCATGATAGGTAGTCTGAGTATGCACCCCGAGTTAGCCAATGC
CCACAATGTCATTGTGACAGAGAGGGTTGTTTCTGGTGCTGGCGTAACTGGAATTAGTGGCACCACTGGGATCAGCGGTGGCATAGGCAG
CAGTGGCCTGGTTGGCACCAGCATGGGTGCTGGGAGCGGTGCCCTGAGTGGAGCTGGCATAAGTGGTGGTGGCATTGGCCTGAGCAGCTT
GGGAGGGACAGCCAGCATTGGCCACATGAGGAGTTCCTCTGACCATCACTTTAACCAAACCATTGGGTCCGCCTCCCCTAGCACAGCTCG
AAGTCGAATCACAAAGTATAGTACCGTGCAATATAGCAAGTAGTCAGGACCCCAGCTCACTTTTTCATAGTCATTGTGGTTTAGATCCAA
TTCCCACCACTAAAAAACCAACAATGTGATTTATAACGCACAACTTCGTGCTCAGGTCATCTAGGAGCAAGGTGAGAAATCACAATGAGA
AAAATAAATGGAAACACCACTGCTAGGGGAGAGCTCTCCTTAGCATTCATAAACTTTTCTCTTATATTAGGACTAAGGAACTAAAACTTG
AGGCAGAGTCTTCTTTGTGCCTGAGTGGCCTGTAGTCCATCTCCAGCATGTAACTGGCCTTACGATGGCAATTGGCATCATTCTCCTTGC
TCTGTTTTGCTTTTCCATATAGCTCGAGCAAAATTCAAAAAGAACTAAATATGCAATATATGTTCATATCTATGGGAAAAATCTAAAATG
TGTGCCAGATGCCCTGTTGGTTTCACAGATAACATAAATAAAAATTCAACCACAGATTTATACAAGGGTTAACCATTTTTTTTAAGTTTG
ACTACATAGTCAAGTCCACAAGCCATCAAGCACTCCTACCTTAATTATTGCACTAGAGAAAATAAATTCCAAATTAGGAAGTGTTTCCTA
GGAGGAAAATTCCATTAGAGAGTGGCAATAGGATGAGGTTTCTTCAGGGTAAACTAGCAATGCCTGAGCCTGAACCTTAATGTGGGGCCT
CAGTTAAATCTCCTGTGGAGTCAAGGATTCTTCTGATTCTAGTGTGTGTTTAGTGATAGATGTAGTCTTGACGAATATTGCTTACTGGTG
AGGTTGAGGAATATCACACTCGTCTTTCCCTTTACCACTGTGGTTTTGACTTAAGAAAGCAAAACTCACTAAGTTTACTTCTCGAATTGA
AGCAAGTGAGGCCTGACATGGTTGTCATCACTAGTGGCAAATGACCTTCCAAGTAAGCAGATGGGAACTGAATTGTGTTTTCAGGTTTTG
TTTTTAGTAGGTGATATTCATTCGTATCCAGCTCTTTATTACATAGCTCTGAAGTTAAAATGATTTACATAGGCCGAGCTGTGGACAAAA
AAAAAAGAAGCAGCAGCTTGTAGTATGCTTAAGCTTTGGGGAATTTTTTTTTAAGGGGATCTAAAAAAATGTTTTTAGAACATGTAAAAT
GTTTAATGGTGAAAGTTGGAAAAGAATTCTTCTGTAAAGTAATACCATGCTAATTATTCGCTTTTAGTAAGTAAAGTAGTGGTTGCTTTA
GCAAACCTCTGCTGCCATTTTGCAGGAATCAACCAGGAACCTTTAGCAGAATTGACAATATGGTGTTGATAAGCATGAAATAATAATAGA
AACCTATTCTGCTAGTTTATCTCACCCTCTAATTTTTCTCACTAGCATAAATTTTAAATTCCTGATTTGATTTGTCAATAAGATCTTGGC
TTATATATGCTGATTTATAGGTAGTGTCCAAATTATATAGTATAACATATTTTTCTAGTTTCAAAATTTAGTAATGTCCTATTTATGATA
TATCATTTCTGTGTGTTTGCTATGTAGTATTACCCAATTAAAAATCTCTAAAAAGAATTAAAGCATTCTAAGAAAAAGGTAAATTTACTA
TTGCATGGTACAGAAATTTTTTCTTTCTTAAATACAATGTTACTATAAGCTCACTAAAATGAAACTCTATATGACAAAATAAAATTAGAA

>93317_93317_6_TPGS2-DSG1_TPGS2_chr18_34398857_ENST00000593035_DSG1_chr18_28906544_ENST00000257192_length(amino acids)=1129AA_BP=95
MRRAFRRRELPFPACHEIGLGAEAGSGPPPAPAARESRSRAMEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHM
ISSWEQVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIF
VINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNL
NSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQE
NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKAS
AISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKY
QGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAG
IGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGR
EMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPA
GSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGV
LHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLT
IHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TPGS2-DSG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TPGS2-DSG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TPGS2-DSG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource