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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TPI1-SMARCC2 (FusionGDB2 ID:93331)

Fusion Gene Summary for TPI1-SMARCC2

check button Fusion gene summary
Fusion gene informationFusion gene name: TPI1-SMARCC2
Fusion gene ID: 93331
HgeneTgene
Gene symbol

TPI1

SMARCC2

Gene ID

7167

6601

Gene nametriosephosphate isomerase 1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
SynonymsHEL-S-49|TIM|TPI|TPIDBAF170|CRACC2|CSS8|Rsc8
Cytomap

12p13.31

12q13.2

Type of geneprotein-codingprotein-coding
Descriptiontriosephosphate isomeraseepididymis secretory protein Li 49methylglyoxal synthasetriose-phosphate isomeraseSWI/SNF complex subunit SMARCC2SWI/SNF complex 170 kDa subunitSWI3-like proteinchromatin remodeling complex BAF170 subunitmammalian chromatin remodeling complex BRG1-associated factor 170
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000229270, ENST00000396705, 
ENST00000488464, ENST00000535434, 
ENST00000550859, ENST00000394023, 
ENST00000267064, ENST00000347471, 
ENST00000550164, 
Fusion gene scores* DoF score9 X 8 X 2=14418 X 18 X 7=2268
# samples 919
** MAII scorelog2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2268*10)=-3.57734931661128
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TPI1 [Title/Abstract] AND SMARCC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTPI1(6978937)-SMARCC2(56557549), # samples:1
Anticipated loss of major functional domain due to fusion event.TPI1-SMARCC2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TPI1-SMARCC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TPI1-SMARCC2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TPI1-SMARCC2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTPI1

GO:0046166

glyceraldehyde-3-phosphate biosynthetic process

18562316

TgeneSMARCC2

GO:0006337

nucleosome disassembly

8895581

TgeneSMARCC2

GO:0006338

chromatin remodeling

10078207|11018012|11726552

TgeneSMARCC2

GO:0045892

negative regulation of transcription, DNA-templated

12192000

TgeneSMARCC2

GO:0045893

positive regulation of transcription, DNA-templated

11018012


check buttonFusion gene breakpoints across TPI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMARCC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1350TPI1chr12

6978937

+SMARCC2chr12

56557549

-


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Fusion Gene ORF analysis for TPI1-SMARCC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000229270ENST00000550859TPI1chr12

6978937

+SMARCC2chr12

56557549

-
5CDS-intronENST00000396705ENST00000550859TPI1chr12

6978937

+SMARCC2chr12

56557549

-
5CDS-intronENST00000488464ENST00000550859TPI1chr12

6978937

+SMARCC2chr12

56557549

-
5CDS-intronENST00000535434ENST00000550859TPI1chr12

6978937

+SMARCC2chr12

56557549

-
Frame-shiftENST00000229270ENST00000394023TPI1chr12

6978937

+SMARCC2chr12

56557549

-
Frame-shiftENST00000396705ENST00000394023TPI1chr12

6978937

+SMARCC2chr12

56557549

-
Frame-shiftENST00000488464ENST00000394023TPI1chr12

6978937

+SMARCC2chr12

56557549

-
Frame-shiftENST00000535434ENST00000394023TPI1chr12

6978937

+SMARCC2chr12

56557549

-
In-frameENST00000229270ENST00000267064TPI1chr12

6978937

+SMARCC2chr12

56557549

-
In-frameENST00000229270ENST00000347471TPI1chr12

6978937

+SMARCC2chr12

56557549

-
In-frameENST00000229270ENST00000550164TPI1chr12

6978937

+SMARCC2chr12

56557549

-
In-frameENST00000396705ENST00000267064TPI1chr12

6978937

+SMARCC2chr12

56557549

-
In-frameENST00000396705ENST00000347471TPI1chr12

6978937

+SMARCC2chr12

56557549

-
In-frameENST00000396705ENST00000550164TPI1chr12

6978937

+SMARCC2chr12

56557549

-
In-frameENST00000488464ENST00000267064TPI1chr12

6978937

+SMARCC2chr12

56557549

-
In-frameENST00000488464ENST00000347471TPI1chr12

6978937

+SMARCC2chr12

56557549

-
In-frameENST00000488464ENST00000550164TPI1chr12

6978937

+SMARCC2chr12

56557549

-
In-frameENST00000535434ENST00000267064TPI1chr12

6978937

+SMARCC2chr12

56557549

-
In-frameENST00000535434ENST00000347471TPI1chr12

6978937

+SMARCC2chr12

56557549

-
In-frameENST00000535434ENST00000550164TPI1chr12

6978937

+SMARCC2chr12

56557549

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000229270TPI1chr126978937+ENST00000550164SMARCC2chr1256557549-14299911721269365
ENST00000229270TPI1chr126978937+ENST00000347471SMARCC2chr1256557549-14279911721269365
ENST00000229270TPI1chr126978937+ENST00000267064SMARCC2chr1256557549-14129911721269365
ENST00000396705TPI1chr126978937+ENST00000550164SMARCC2chr1256557549-101757936857273
ENST00000396705TPI1chr126978937+ENST00000347471SMARCC2chr1256557549-101557936857273
ENST00000396705TPI1chr126978937+ENST00000267064SMARCC2chr1256557549-100057936857273
ENST00000488464TPI1chr126978937+ENST00000550164SMARCC2chr1256557549-1022584287862191
ENST00000488464TPI1chr126978937+ENST00000347471SMARCC2chr1256557549-1020584287862191
ENST00000488464TPI1chr126978937+ENST00000267064SMARCC2chr1256557549-1005584287862191
ENST00000535434TPI1chr126978937+ENST00000550164SMARCC2chr1256557549-12628241971102301
ENST00000535434TPI1chr126978937+ENST00000347471SMARCC2chr1256557549-12608241971102301
ENST00000535434TPI1chr126978937+ENST00000267064SMARCC2chr1256557549-12458241971102301

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000229270ENST00000550164TPI1chr126978937+SMARCC2chr1256557549-0.0087151280.99128485
ENST00000229270ENST00000347471TPI1chr126978937+SMARCC2chr1256557549-0.0089637570.9910362
ENST00000229270ENST00000267064TPI1chr126978937+SMARCC2chr1256557549-0.0109634540.9890365
ENST00000396705ENST00000550164TPI1chr126978937+SMARCC2chr1256557549-0.033642020.966358
ENST00000396705ENST00000347471TPI1chr126978937+SMARCC2chr1256557549-0.0342547260.9657452
ENST00000396705ENST00000267064TPI1chr126978937+SMARCC2chr1256557549-0.0394311250.9605689
ENST00000488464ENST00000550164TPI1chr126978937+SMARCC2chr1256557549-0.142990890.85700905
ENST00000488464ENST00000347471TPI1chr126978937+SMARCC2chr1256557549-0.143345530.85665447
ENST00000488464ENST00000267064TPI1chr126978937+SMARCC2chr1256557549-0.139454510.8605455
ENST00000535434ENST00000550164TPI1chr126978937+SMARCC2chr1256557549-0.140995850.8590042
ENST00000535434ENST00000347471TPI1chr126978937+SMARCC2chr1256557549-0.141232390.8587676
ENST00000535434ENST00000267064TPI1chr126978937+SMARCC2chr1256557549-0.134705420.8652946

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Fusion Genomic Features for TPI1-SMARCC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TPI1-SMARCC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:6978937/chr12:56557549)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSMARCC2chr12:6978937chr12:56557549ENST000002670642628907_93411891215.0Coiled coilOntology_term=ECO:0000255
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003474712729907_93411051131.0Coiled coilOntology_term=ECO:0000255
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003940232830907_93411271153.0Coiled coilOntology_term=ECO:0000255
TgeneSMARCC2chr12:6978937chr12:56557549ENST000002670642628186_18911891215.0Compositional biasNote=Poly-Glu
TgeneSMARCC2chr12:6978937chr12:56557549ENST000002670642628747_85511891215.0Compositional biasNote=Glu-rich
TgeneSMARCC2chr12:6978937chr12:56557549ENST000002670642628861_87011891215.0Compositional biasNote=Poly-Ala
TgeneSMARCC2chr12:6978937chr12:56557549ENST000002670642628956_96011891215.0Compositional biasNote=Poly-Gln
TgeneSMARCC2chr12:6978937chr12:56557549ENST000002670642628961_121311891215.0Compositional biasNote=Pro-rich
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003474712729186_18911051131.0Compositional biasNote=Poly-Glu
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003474712729747_85511051131.0Compositional biasNote=Glu-rich
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003474712729861_87011051131.0Compositional biasNote=Poly-Ala
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003474712729956_96011051131.0Compositional biasNote=Poly-Gln
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003474712729961_121311051131.0Compositional biasNote=Pro-rich
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003940232830186_18911271153.0Compositional biasNote=Poly-Glu
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003940232830747_85511271153.0Compositional biasNote=Glu-rich
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003940232830861_87011271153.0Compositional biasNote=Poly-Ala
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003940232830956_96011271153.0Compositional biasNote=Poly-Gln
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003940232830961_121311271153.0Compositional biasNote=Pro-rich
TgeneSMARCC2chr12:6978937chr12:56557549ENST000002670642628424_52111891215.0DomainSWIRM
TgeneSMARCC2chr12:6978937chr12:56557549ENST000002670642628596_64711891215.0DomainSANT
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003474712729424_52111051131.0DomainSWIRM
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003474712729596_64711051131.0DomainSANT
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003940232830424_52111271153.0DomainSWIRM
TgeneSMARCC2chr12:6978937chr12:56557549ENST000003940232830596_64711271153.0DomainSANT


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Fusion Gene Sequence for TPI1-SMARCC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93331_93331_1_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000229270_SMARCC2_chr12_56557549_ENST00000267064_length(transcript)=1412nt_BP=991nt
GGAGGTTGTCTATCCCACAGTTGGAGAGGGGCCCTCTCTGCCCCAGTGGGCGATCTGGGCTACGGCCAAGTTGCCACCAGCTAGTTCCGC
TTGAAAACCACTTCTGGCCCCGTGGGGGACTCAAGTCGCCAAGCGAGGGTTCCCCTGAGCGCCGGAGCTCACAGGTCTCGCCTTGTCCCG
AAAGCCCCGCAATCGAGGCGGAGGCGACCGAGCCCCCGACTCTCCTAGAACGTTGCCACAAGAAGGGGGAACGTCGGAACAGTGCATCAT
CGGGCGGCGGCCGGGGCGGCGGCAGGAGGGCGGGCGGGGGGCAGGGCTCCGGGGGACTGGGCGGGCCATGGCGGAGGACGGCGAGGAGGC
GGAGTTCCACTTCGCGGCGCTCTATATAAGTGGGCAGTGGCCGCGACTGCGCGCAGACACTGACCTTCAGCGCCTCGGCTCCAGCGCCAT
GGCGCCCTCCAGGAAGTTCTTCGTTGGGGGAAACTGGAAGATGAACGGGCGGAAGCAGAGTCTGGGGGAGCTCATCGGCACTCTGAACGC
GGCCAAGGTGCCGGCCGACACCGAGGTGGTTTGTGCTCCCCCTACTGCCTATATCGACTTCGCCCGGCAGAAGCTAGATCCCAAGATTGC
TGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTGGGGAGATCAGCCCTGGCATGATCAAAGACTGCGGAGCCACGTG
GGTGGTCCTGGGGCACTCAGAGAGAAGGCATGTCTTTGGGGAGTCAGATGAGCTGATTGGGCAGAAAGTGGCCCATGCTCTGGCAGAGGG
ACTCGGAGTAATCGCCTGCATTGGGGAGAAGCTAGATGAAAGGGAAGCTGGCATCACTGAGAAGGTTGTTTTCGAGCAGACAAAGGTCAT
CGCAGATAACGTGAAGGACTGGAGCAAGGTCGTCCTGGCCTATGAGCCTGTGTGGGCCATTGGTACTGGCAAGACTGCAACACCCCAACA
GACCCAGGCACCCCCCTGCCTCCAGACCCCACAGCCCCGAGCCCAGGCACGGTCACCCCTGTGCCACCTCCACAGTGAGGAGCCAGCCAG
ACATCTCTCCCCCTCACCCCCTGTGGACATCACGGTTCCAGGAACAGCCCTTCCCCCACCACTGGGACCCTCCCCAGCCTGGAGAGTTCA
TCACTACGTAAGGAAAGCTCCTTCCGCCCCTCCAAAGCCCTCACCATGCCTAACAGAGGCATGCATTTTTATATCAGATTATTCAAGGAC
TTCTGTTTAAAAGATGTTTATAATGTCTGGGAGAGAGGATAGGATGGGAATGCTGCCCTAAAGGAAGGGCTGGTGAAAGGTGTTTATACA

>93331_93331_1_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000229270_SMARCC2_chr12_56557549_ENST00000267064_length(amino acids)=365AA_BP=272
MSRKPRNRGGGDRAPDSPRTLPQEGGTSEQCIIGRRPGRRQEGGRGAGLRGTGRAMAEDGEEAEFHFAALYISGQWPRLRADTDLQRLGS
SAMAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCG
ATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTAT
PQQTQAPPCLQTPQPRAQARSPLCHLHSEEPARHLSPSPPVDITVPGTALPPPLGPSPAWRVHHYVRKAPSAPPKPSPCLTEACIFISDY

--------------------------------------------------------------
>93331_93331_2_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000229270_SMARCC2_chr12_56557549_ENST00000347471_length(transcript)=1427nt_BP=991nt
GGAGGTTGTCTATCCCACAGTTGGAGAGGGGCCCTCTCTGCCCCAGTGGGCGATCTGGGCTACGGCCAAGTTGCCACCAGCTAGTTCCGC
TTGAAAACCACTTCTGGCCCCGTGGGGGACTCAAGTCGCCAAGCGAGGGTTCCCCTGAGCGCCGGAGCTCACAGGTCTCGCCTTGTCCCG
AAAGCCCCGCAATCGAGGCGGAGGCGACCGAGCCCCCGACTCTCCTAGAACGTTGCCACAAGAAGGGGGAACGTCGGAACAGTGCATCAT
CGGGCGGCGGCCGGGGCGGCGGCAGGAGGGCGGGCGGGGGGCAGGGCTCCGGGGGACTGGGCGGGCCATGGCGGAGGACGGCGAGGAGGC
GGAGTTCCACTTCGCGGCGCTCTATATAAGTGGGCAGTGGCCGCGACTGCGCGCAGACACTGACCTTCAGCGCCTCGGCTCCAGCGCCAT
GGCGCCCTCCAGGAAGTTCTTCGTTGGGGGAAACTGGAAGATGAACGGGCGGAAGCAGAGTCTGGGGGAGCTCATCGGCACTCTGAACGC
GGCCAAGGTGCCGGCCGACACCGAGGTGGTTTGTGCTCCCCCTACTGCCTATATCGACTTCGCCCGGCAGAAGCTAGATCCCAAGATTGC
TGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTGGGGAGATCAGCCCTGGCATGATCAAAGACTGCGGAGCCACGTG
GGTGGTCCTGGGGCACTCAGAGAGAAGGCATGTCTTTGGGGAGTCAGATGAGCTGATTGGGCAGAAAGTGGCCCATGCTCTGGCAGAGGG
ACTCGGAGTAATCGCCTGCATTGGGGAGAAGCTAGATGAAAGGGAAGCTGGCATCACTGAGAAGGTTGTTTTCGAGCAGACAAAGGTCAT
CGCAGATAACGTGAAGGACTGGAGCAAGGTCGTCCTGGCCTATGAGCCTGTGTGGGCCATTGGTACTGGCAAGACTGCAACACCCCAACA
GACCCAGGCACCCCCCTGCCTCCAGACCCCACAGCCCCGAGCCCAGGCACGGTCACCCCTGTGCCACCTCCACAGTGAGGAGCCAGCCAG
ACATCTCTCCCCCTCACCCCCTGTGGACATCACGGTTCCAGGAACAGCCCTTCCCCCACCACTGGGACCCTCCCCAGCCTGGAGAGTTCA
TCACTACGTAAGGAAAGCTCCTTCCGCCCCTCCAAAGCCCTCACCATGCCTAACAGAGGCATGCATTTTTATATCAGATTATTCAAGGAC
TTCTGTTTAAAAGATGTTTATAATGTCTGGGAGAGAGGATAGGATGGGAATGCTGCCCTAAAGGAAGGGCTGGTGAAAGGTGTTTATACA

>93331_93331_2_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000229270_SMARCC2_chr12_56557549_ENST00000347471_length(amino acids)=365AA_BP=272
MSRKPRNRGGGDRAPDSPRTLPQEGGTSEQCIIGRRPGRRQEGGRGAGLRGTGRAMAEDGEEAEFHFAALYISGQWPRLRADTDLQRLGS
SAMAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCG
ATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTAT
PQQTQAPPCLQTPQPRAQARSPLCHLHSEEPARHLSPSPPVDITVPGTALPPPLGPSPAWRVHHYVRKAPSAPPKPSPCLTEACIFISDY

--------------------------------------------------------------
>93331_93331_3_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000229270_SMARCC2_chr12_56557549_ENST00000550164_length(transcript)=1429nt_BP=991nt
GGAGGTTGTCTATCCCACAGTTGGAGAGGGGCCCTCTCTGCCCCAGTGGGCGATCTGGGCTACGGCCAAGTTGCCACCAGCTAGTTCCGC
TTGAAAACCACTTCTGGCCCCGTGGGGGACTCAAGTCGCCAAGCGAGGGTTCCCCTGAGCGCCGGAGCTCACAGGTCTCGCCTTGTCCCG
AAAGCCCCGCAATCGAGGCGGAGGCGACCGAGCCCCCGACTCTCCTAGAACGTTGCCACAAGAAGGGGGAACGTCGGAACAGTGCATCAT
CGGGCGGCGGCCGGGGCGGCGGCAGGAGGGCGGGCGGGGGGCAGGGCTCCGGGGGACTGGGCGGGCCATGGCGGAGGACGGCGAGGAGGC
GGAGTTCCACTTCGCGGCGCTCTATATAAGTGGGCAGTGGCCGCGACTGCGCGCAGACACTGACCTTCAGCGCCTCGGCTCCAGCGCCAT
GGCGCCCTCCAGGAAGTTCTTCGTTGGGGGAAACTGGAAGATGAACGGGCGGAAGCAGAGTCTGGGGGAGCTCATCGGCACTCTGAACGC
GGCCAAGGTGCCGGCCGACACCGAGGTGGTTTGTGCTCCCCCTACTGCCTATATCGACTTCGCCCGGCAGAAGCTAGATCCCAAGATTGC
TGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTGGGGAGATCAGCCCTGGCATGATCAAAGACTGCGGAGCCACGTG
GGTGGTCCTGGGGCACTCAGAGAGAAGGCATGTCTTTGGGGAGTCAGATGAGCTGATTGGGCAGAAAGTGGCCCATGCTCTGGCAGAGGG
ACTCGGAGTAATCGCCTGCATTGGGGAGAAGCTAGATGAAAGGGAAGCTGGCATCACTGAGAAGGTTGTTTTCGAGCAGACAAAGGTCAT
CGCAGATAACGTGAAGGACTGGAGCAAGGTCGTCCTGGCCTATGAGCCTGTGTGGGCCATTGGTACTGGCAAGACTGCAACACCCCAACA
GACCCAGGCACCCCCCTGCCTCCAGACCCCACAGCCCCGAGCCCAGGCACGGTCACCCCTGTGCCACCTCCACAGTGAGGAGCCAGCCAG
ACATCTCTCCCCCTCACCCCCTGTGGACATCACGGTTCCAGGAACAGCCCTTCCCCCACCACTGGGACCCTCCCCAGCCTGGAGAGTTCA
TCACTACGTAAGGAAAGCTCCTTCCGCCCCTCCAAAGCCCTCACCATGCCTAACAGAGGCATGCATTTTTATATCAGATTATTCAAGGAC
TTCTGTTTAAAAGATGTTTATAATGTCTGGGAGAGAGGATAGGATGGGAATGCTGCCCTAAAGGAAGGGCTGGTGAAAGGTGTTTATACA

>93331_93331_3_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000229270_SMARCC2_chr12_56557549_ENST00000550164_length(amino acids)=365AA_BP=272
MSRKPRNRGGGDRAPDSPRTLPQEGGTSEQCIIGRRPGRRQEGGRGAGLRGTGRAMAEDGEEAEFHFAALYISGQWPRLRADTDLQRLGS
SAMAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCG
ATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTAT
PQQTQAPPCLQTPQPRAQARSPLCHLHSEEPARHLSPSPPVDITVPGTALPPPLGPSPAWRVHHYVRKAPSAPPKPSPCLTEACIFISDY

--------------------------------------------------------------
>93331_93331_4_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000396705_SMARCC2_chr12_56557549_ENST00000267064_length(transcript)=1000nt_BP=579nt
GCAGACACTGACCTTCAGCGCCTCGGCTCCAGCGCCATGGCGCCCTCCAGGAAGTTCTTCGTTGGGGGAAACTGGAAGATGAACGGGCGG
AAGCAGAGTCTGGGGGAGCTCATCGGCACTCTGAACGCGGCCAAGGTGCCGGCCGACACCGAGGTGGTTTGTGCTCCCCCTACTGCCTAT
ATCGACTTCGCCCGGCAGAAGCTAGATCCCAAGATTGCTGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTGGGGAG
ATCAGCCCTGGCATGATCAAAGACTGCGGAGCCACGTGGGTGGTCCTGGGGCACTCAGAGAGAAGGCATGTCTTTGGGGAGTCAGATGAG
CTGATTGGGCAGAAAGTGGCCCATGCTCTGGCAGAGGGACTCGGAGTAATCGCCTGCATTGGGGAGAAGCTAGATGAAAGGGAAGCTGGC
ATCACTGAGAAGGTTGTTTTCGAGCAGACAAAGGTCATCGCAGATAACGTGAAGGACTGGAGCAAGGTCGTCCTGGCCTATGAGCCTGTG
TGGGCCATTGGTACTGGCAAGACTGCAACACCCCAACAGACCCAGGCACCCCCCTGCCTCCAGACCCCACAGCCCCGAGCCCAGGCACGG
TCACCCCTGTGCCACCTCCACAGTGAGGAGCCAGCCAGACATCTCTCCCCCTCACCCCCTGTGGACATCACGGTTCCAGGAACAGCCCTT
CCCCCACCACTGGGACCCTCCCCAGCCTGGAGAGTTCATCACTACGTAAGGAAAGCTCCTTCCGCCCCTCCAAAGCCCTCACCATGCCTA
ACAGAGGCATGCATTTTTATATCAGATTATTCAAGGACTTCTGTTTAAAAGATGTTTATAATGTCTGGGAGAGAGGATAGGATGGGAATG
CTGCCCTAAAGGAAGGGCTGGTGAAAGGTGTTTATACAAGGTTCTATTAACCACTTCTAAGGGTACACCTCCCTCCAAACTACTGCATTT

>93331_93331_4_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000396705_SMARCC2_chr12_56557549_ENST00000267064_length(amino acids)=273AA_BP=180
MAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGAT
WVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQ
QTQAPPCLQTPQPRAQARSPLCHLHSEEPARHLSPSPPVDITVPGTALPPPLGPSPAWRVHHYVRKAPSAPPKPSPCLTEACIFISDYSR

--------------------------------------------------------------
>93331_93331_5_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000396705_SMARCC2_chr12_56557549_ENST00000347471_length(transcript)=1015nt_BP=579nt
GCAGACACTGACCTTCAGCGCCTCGGCTCCAGCGCCATGGCGCCCTCCAGGAAGTTCTTCGTTGGGGGAAACTGGAAGATGAACGGGCGG
AAGCAGAGTCTGGGGGAGCTCATCGGCACTCTGAACGCGGCCAAGGTGCCGGCCGACACCGAGGTGGTTTGTGCTCCCCCTACTGCCTAT
ATCGACTTCGCCCGGCAGAAGCTAGATCCCAAGATTGCTGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTGGGGAG
ATCAGCCCTGGCATGATCAAAGACTGCGGAGCCACGTGGGTGGTCCTGGGGCACTCAGAGAGAAGGCATGTCTTTGGGGAGTCAGATGAG
CTGATTGGGCAGAAAGTGGCCCATGCTCTGGCAGAGGGACTCGGAGTAATCGCCTGCATTGGGGAGAAGCTAGATGAAAGGGAAGCTGGC
ATCACTGAGAAGGTTGTTTTCGAGCAGACAAAGGTCATCGCAGATAACGTGAAGGACTGGAGCAAGGTCGTCCTGGCCTATGAGCCTGTG
TGGGCCATTGGTACTGGCAAGACTGCAACACCCCAACAGACCCAGGCACCCCCCTGCCTCCAGACCCCACAGCCCCGAGCCCAGGCACGG
TCACCCCTGTGCCACCTCCACAGTGAGGAGCCAGCCAGACATCTCTCCCCCTCACCCCCTGTGGACATCACGGTTCCAGGAACAGCCCTT
CCCCCACCACTGGGACCCTCCCCAGCCTGGAGAGTTCATCACTACGTAAGGAAAGCTCCTTCCGCCCCTCCAAAGCCCTCACCATGCCTA
ACAGAGGCATGCATTTTTATATCAGATTATTCAAGGACTTCTGTTTAAAAGATGTTTATAATGTCTGGGAGAGAGGATAGGATGGGAATG
CTGCCCTAAAGGAAGGGCTGGTGAAAGGTGTTTATACAAGGTTCTATTAACCACTTCTAAGGGTACACCTCCCTCCAAACTACTGCATTT

>93331_93331_5_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000396705_SMARCC2_chr12_56557549_ENST00000347471_length(amino acids)=273AA_BP=180
MAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGAT
WVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQ
QTQAPPCLQTPQPRAQARSPLCHLHSEEPARHLSPSPPVDITVPGTALPPPLGPSPAWRVHHYVRKAPSAPPKPSPCLTEACIFISDYSR

--------------------------------------------------------------
>93331_93331_6_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000396705_SMARCC2_chr12_56557549_ENST00000550164_length(transcript)=1017nt_BP=579nt
GCAGACACTGACCTTCAGCGCCTCGGCTCCAGCGCCATGGCGCCCTCCAGGAAGTTCTTCGTTGGGGGAAACTGGAAGATGAACGGGCGG
AAGCAGAGTCTGGGGGAGCTCATCGGCACTCTGAACGCGGCCAAGGTGCCGGCCGACACCGAGGTGGTTTGTGCTCCCCCTACTGCCTAT
ATCGACTTCGCCCGGCAGAAGCTAGATCCCAAGATTGCTGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTGGGGAG
ATCAGCCCTGGCATGATCAAAGACTGCGGAGCCACGTGGGTGGTCCTGGGGCACTCAGAGAGAAGGCATGTCTTTGGGGAGTCAGATGAG
CTGATTGGGCAGAAAGTGGCCCATGCTCTGGCAGAGGGACTCGGAGTAATCGCCTGCATTGGGGAGAAGCTAGATGAAAGGGAAGCTGGC
ATCACTGAGAAGGTTGTTTTCGAGCAGACAAAGGTCATCGCAGATAACGTGAAGGACTGGAGCAAGGTCGTCCTGGCCTATGAGCCTGTG
TGGGCCATTGGTACTGGCAAGACTGCAACACCCCAACAGACCCAGGCACCCCCCTGCCTCCAGACCCCACAGCCCCGAGCCCAGGCACGG
TCACCCCTGTGCCACCTCCACAGTGAGGAGCCAGCCAGACATCTCTCCCCCTCACCCCCTGTGGACATCACGGTTCCAGGAACAGCCCTT
CCCCCACCACTGGGACCCTCCCCAGCCTGGAGAGTTCATCACTACGTAAGGAAAGCTCCTTCCGCCCCTCCAAAGCCCTCACCATGCCTA
ACAGAGGCATGCATTTTTATATCAGATTATTCAAGGACTTCTGTTTAAAAGATGTTTATAATGTCTGGGAGAGAGGATAGGATGGGAATG
CTGCCCTAAAGGAAGGGCTGGTGAAAGGTGTTTATACAAGGTTCTATTAACCACTTCTAAGGGTACACCTCCCTCCAAACTACTGCATTT

>93331_93331_6_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000396705_SMARCC2_chr12_56557549_ENST00000550164_length(amino acids)=273AA_BP=180
MAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGAT
WVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQ
QTQAPPCLQTPQPRAQARSPLCHLHSEEPARHLSPSPPVDITVPGTALPPPLGPSPAWRVHHYVRKAPSAPPKPSPCLTEACIFISDYSR

--------------------------------------------------------------
>93331_93331_7_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000488464_SMARCC2_chr12_56557549_ENST00000267064_length(transcript)=1005nt_BP=584nt
GACTCCTCCCCTTCCTCGCCGGCGTCCGCGTCCCCGCGCCGAGCTGCTCGGGCTCCCTGAGCCCCAGATCTGACCCCTTCCCTTCGGCAA
CCTGAACGACTCCCGCCTTCCACGGAAGGGACCGAGCCCGTGCCAAACAGGCTGAGCGATTTGGGAAGGTGGTTTGTGCTCCCCCTACTG
CCTATATCGACTTCGCCCGGCAGAAGCTAGATCCCAAGATTGCTGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTG
GGGAGATCAGCCCTGGCATGATCAAAGACTGCGGAGCCACGTGGGTGGTCCTGGGGCACTCAGAGAGAAGGCATGTCTTTGGGGAGTCAG
ATGAGCTGATTGGGCAGAAAGTGGCCCATGCTCTGGCAGAGGGACTCGGAGTAATCGCCTGCATTGGGGAGAAGCTAGATGAAAGGGAAG
CTGGCATCACTGAGAAGGTTGTTTTCGAGCAGACAAAGGTCATCGCAGATAACGTGAAGGACTGGAGCAAGGTCGTCCTGGCCTATGAGC
CTGTGTGGGCCATTGGTACTGGCAAGACTGCAACACCCCAACAGACCCAGGCACCCCCCTGCCTCCAGACCCCACAGCCCCGAGCCCAGG
CACGGTCACCCCTGTGCCACCTCCACAGTGAGGAGCCAGCCAGACATCTCTCCCCCTCACCCCCTGTGGACATCACGGTTCCAGGAACAG
CCCTTCCCCCACCACTGGGACCCTCCCCAGCCTGGAGAGTTCATCACTACGTAAGGAAAGCTCCTTCCGCCCCTCCAAAGCCCTCACCAT
GCCTAACAGAGGCATGCATTTTTATATCAGATTATTCAAGGACTTCTGTTTAAAAGATGTTTATAATGTCTGGGAGAGAGGATAGGATGG
GAATGCTGCCCTAAAGGAAGGGCTGGTGAAAGGTGTTTATACAAGGTTCTATTAACCACTTCTAAGGGTACACCTCCCTCCAAACTACTG

>93331_93331_7_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000488464_SMARCC2_chr12_56557549_ENST00000267064_length(amino acids)=191AA_BP=98
MIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIG
TGKTATPQQTQAPPCLQTPQPRAQARSPLCHLHSEEPARHLSPSPPVDITVPGTALPPPLGPSPAWRVHHYVRKAPSAPPKPSPCLTEAC

--------------------------------------------------------------
>93331_93331_8_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000488464_SMARCC2_chr12_56557549_ENST00000347471_length(transcript)=1020nt_BP=584nt
GACTCCTCCCCTTCCTCGCCGGCGTCCGCGTCCCCGCGCCGAGCTGCTCGGGCTCCCTGAGCCCCAGATCTGACCCCTTCCCTTCGGCAA
CCTGAACGACTCCCGCCTTCCACGGAAGGGACCGAGCCCGTGCCAAACAGGCTGAGCGATTTGGGAAGGTGGTTTGTGCTCCCCCTACTG
CCTATATCGACTTCGCCCGGCAGAAGCTAGATCCCAAGATTGCTGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTG
GGGAGATCAGCCCTGGCATGATCAAAGACTGCGGAGCCACGTGGGTGGTCCTGGGGCACTCAGAGAGAAGGCATGTCTTTGGGGAGTCAG
ATGAGCTGATTGGGCAGAAAGTGGCCCATGCTCTGGCAGAGGGACTCGGAGTAATCGCCTGCATTGGGGAGAAGCTAGATGAAAGGGAAG
CTGGCATCACTGAGAAGGTTGTTTTCGAGCAGACAAAGGTCATCGCAGATAACGTGAAGGACTGGAGCAAGGTCGTCCTGGCCTATGAGC
CTGTGTGGGCCATTGGTACTGGCAAGACTGCAACACCCCAACAGACCCAGGCACCCCCCTGCCTCCAGACCCCACAGCCCCGAGCCCAGG
CACGGTCACCCCTGTGCCACCTCCACAGTGAGGAGCCAGCCAGACATCTCTCCCCCTCACCCCCTGTGGACATCACGGTTCCAGGAACAG
CCCTTCCCCCACCACTGGGACCCTCCCCAGCCTGGAGAGTTCATCACTACGTAAGGAAAGCTCCTTCCGCCCCTCCAAAGCCCTCACCAT
GCCTAACAGAGGCATGCATTTTTATATCAGATTATTCAAGGACTTCTGTTTAAAAGATGTTTATAATGTCTGGGAGAGAGGATAGGATGG
GAATGCTGCCCTAAAGGAAGGGCTGGTGAAAGGTGTTTATACAAGGTTCTATTAACCACTTCTAAGGGTACACCTCCCTCCAAACTACTG

>93331_93331_8_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000488464_SMARCC2_chr12_56557549_ENST00000347471_length(amino acids)=191AA_BP=98
MIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIG
TGKTATPQQTQAPPCLQTPQPRAQARSPLCHLHSEEPARHLSPSPPVDITVPGTALPPPLGPSPAWRVHHYVRKAPSAPPKPSPCLTEAC

--------------------------------------------------------------
>93331_93331_9_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000488464_SMARCC2_chr12_56557549_ENST00000550164_length(transcript)=1022nt_BP=584nt
GACTCCTCCCCTTCCTCGCCGGCGTCCGCGTCCCCGCGCCGAGCTGCTCGGGCTCCCTGAGCCCCAGATCTGACCCCTTCCCTTCGGCAA
CCTGAACGACTCCCGCCTTCCACGGAAGGGACCGAGCCCGTGCCAAACAGGCTGAGCGATTTGGGAAGGTGGTTTGTGCTCCCCCTACTG
CCTATATCGACTTCGCCCGGCAGAAGCTAGATCCCAAGATTGCTGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTG
GGGAGATCAGCCCTGGCATGATCAAAGACTGCGGAGCCACGTGGGTGGTCCTGGGGCACTCAGAGAGAAGGCATGTCTTTGGGGAGTCAG
ATGAGCTGATTGGGCAGAAAGTGGCCCATGCTCTGGCAGAGGGACTCGGAGTAATCGCCTGCATTGGGGAGAAGCTAGATGAAAGGGAAG
CTGGCATCACTGAGAAGGTTGTTTTCGAGCAGACAAAGGTCATCGCAGATAACGTGAAGGACTGGAGCAAGGTCGTCCTGGCCTATGAGC
CTGTGTGGGCCATTGGTACTGGCAAGACTGCAACACCCCAACAGACCCAGGCACCCCCCTGCCTCCAGACCCCACAGCCCCGAGCCCAGG
CACGGTCACCCCTGTGCCACCTCCACAGTGAGGAGCCAGCCAGACATCTCTCCCCCTCACCCCCTGTGGACATCACGGTTCCAGGAACAG
CCCTTCCCCCACCACTGGGACCCTCCCCAGCCTGGAGAGTTCATCACTACGTAAGGAAAGCTCCTTCCGCCCCTCCAAAGCCCTCACCAT
GCCTAACAGAGGCATGCATTTTTATATCAGATTATTCAAGGACTTCTGTTTAAAAGATGTTTATAATGTCTGGGAGAGAGGATAGGATGG
GAATGCTGCCCTAAAGGAAGGGCTGGTGAAAGGTGTTTATACAAGGTTCTATTAACCACTTCTAAGGGTACACCTCCCTCCAAACTACTG

>93331_93331_9_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000488464_SMARCC2_chr12_56557549_ENST00000550164_length(amino acids)=191AA_BP=98
MIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIG
TGKTATPQQTQAPPCLQTPQPRAQARSPLCHLHSEEPARHLSPSPPVDITVPGTALPPPLGPSPAWRVHHYVRKAPSAPPKPSPCLTEAC

--------------------------------------------------------------
>93331_93331_10_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000535434_SMARCC2_chr12_56557549_ENST00000267064_length(transcript)=1245nt_BP=824nt
CTCGCCGGCGTCCGCGTCCCCGCGCCGAGCTGCTCGGGCTCCCTGAGCCCCAGATCTGACCCCTTCCCTTCGGCAACCTGAACGACTCCC
GCCTTCCACGGAAGGGACCGAGCCCGTGCCAAACAGGCTGAGCGATTTGGGAGTGAGGAGCCATCCTACCGCTTTCCCCAACCTGGAAAC
AGCAAAGCGCAAGGCCTCTGAGTCAGTTAGGTCTCTGCCACCCACGGGCAAAGGATGCTCTCCTCCATCCTCCTTCCTCCCTCCACCGAA
ATCGGAGAGCCGCGGGCCTGATCCAAAGAGGCATCCCCTTCTCGTTCATTCCCCAGAGGCCTCAATACAAACCCCAGGAGTTGGCCCCTC
TCCTTTTGCTACAAATCCTTGCCTTGCAAAGGGGAGAGGTGGTTTGTGCTCCCCCTACTGCCTATATCGACTTCGCCCGGCAGAAGCTAG
ATCCCAAGATTGCTGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTGGGGAGATCAGCCCTGGCATGATCAAAGACT
GCGGAGCCACGTGGGTGGTCCTGGGGCACTCAGAGAGAAGGCATGTCTTTGGGGAGTCAGATGAGCTGATTGGGCAGAAAGTGGCCCATG
CTCTGGCAGAGGGACTCGGAGTAATCGCCTGCATTGGGGAGAAGCTAGATGAAAGGGAAGCTGGCATCACTGAGAAGGTTGTTTTCGAGC
AGACAAAGGTCATCGCAGATAACGTGAAGGACTGGAGCAAGGTCGTCCTGGCCTATGAGCCTGTGTGGGCCATTGGTACTGGCAAGACTG
CAACACCCCAACAGACCCAGGCACCCCCCTGCCTCCAGACCCCACAGCCCCGAGCCCAGGCACGGTCACCCCTGTGCCACCTCCACAGTG
AGGAGCCAGCCAGACATCTCTCCCCCTCACCCCCTGTGGACATCACGGTTCCAGGAACAGCCCTTCCCCCACCACTGGGACCCTCCCCAG
CCTGGAGAGTTCATCACTACGTAAGGAAAGCTCCTTCCGCCCCTCCAAAGCCCTCACCATGCCTAACAGAGGCATGCATTTTTATATCAG
ATTATTCAAGGACTTCTGTTTAAAAGATGTTTATAATGTCTGGGAGAGAGGATAGGATGGGAATGCTGCCCTAAAGGAAGGGCTGGTGAA

>93331_93331_10_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000535434_SMARCC2_chr12_56557549_ENST00000267064_length(amino acids)=301AA_BP=208
MSQLGLCHPRAKDALLHPPSSLHRNRRAAGLIQRGIPFSFIPQRPQYKPQELAPLLLLQILALQRGEVVCAPPTAYIDFARQKLDPKIAV
AAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIA
DNVKDWSKVVLAYEPVWAIGTGKTATPQQTQAPPCLQTPQPRAQARSPLCHLHSEEPARHLSPSPPVDITVPGTALPPPLGPSPAWRVHH

--------------------------------------------------------------
>93331_93331_11_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000535434_SMARCC2_chr12_56557549_ENST00000347471_length(transcript)=1260nt_BP=824nt
CTCGCCGGCGTCCGCGTCCCCGCGCCGAGCTGCTCGGGCTCCCTGAGCCCCAGATCTGACCCCTTCCCTTCGGCAACCTGAACGACTCCC
GCCTTCCACGGAAGGGACCGAGCCCGTGCCAAACAGGCTGAGCGATTTGGGAGTGAGGAGCCATCCTACCGCTTTCCCCAACCTGGAAAC
AGCAAAGCGCAAGGCCTCTGAGTCAGTTAGGTCTCTGCCACCCACGGGCAAAGGATGCTCTCCTCCATCCTCCTTCCTCCCTCCACCGAA
ATCGGAGAGCCGCGGGCCTGATCCAAAGAGGCATCCCCTTCTCGTTCATTCCCCAGAGGCCTCAATACAAACCCCAGGAGTTGGCCCCTC
TCCTTTTGCTACAAATCCTTGCCTTGCAAAGGGGAGAGGTGGTTTGTGCTCCCCCTACTGCCTATATCGACTTCGCCCGGCAGAAGCTAG
ATCCCAAGATTGCTGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTGGGGAGATCAGCCCTGGCATGATCAAAGACT
GCGGAGCCACGTGGGTGGTCCTGGGGCACTCAGAGAGAAGGCATGTCTTTGGGGAGTCAGATGAGCTGATTGGGCAGAAAGTGGCCCATG
CTCTGGCAGAGGGACTCGGAGTAATCGCCTGCATTGGGGAGAAGCTAGATGAAAGGGAAGCTGGCATCACTGAGAAGGTTGTTTTCGAGC
AGACAAAGGTCATCGCAGATAACGTGAAGGACTGGAGCAAGGTCGTCCTGGCCTATGAGCCTGTGTGGGCCATTGGTACTGGCAAGACTG
CAACACCCCAACAGACCCAGGCACCCCCCTGCCTCCAGACCCCACAGCCCCGAGCCCAGGCACGGTCACCCCTGTGCCACCTCCACAGTG
AGGAGCCAGCCAGACATCTCTCCCCCTCACCCCCTGTGGACATCACGGTTCCAGGAACAGCCCTTCCCCCACCACTGGGACCCTCCCCAG
CCTGGAGAGTTCATCACTACGTAAGGAAAGCTCCTTCCGCCCCTCCAAAGCCCTCACCATGCCTAACAGAGGCATGCATTTTTATATCAG
ATTATTCAAGGACTTCTGTTTAAAAGATGTTTATAATGTCTGGGAGAGAGGATAGGATGGGAATGCTGCCCTAAAGGAAGGGCTGGTGAA
AGGTGTTTATACAAGGTTCTATTAACCACTTCTAAGGGTACACCTCCCTCCAAACTACTGCATTTTCTATGGATTAAAAAAAAAAAAAAA

>93331_93331_11_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000535434_SMARCC2_chr12_56557549_ENST00000347471_length(amino acids)=301AA_BP=208
MSQLGLCHPRAKDALLHPPSSLHRNRRAAGLIQRGIPFSFIPQRPQYKPQELAPLLLLQILALQRGEVVCAPPTAYIDFARQKLDPKIAV
AAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIA
DNVKDWSKVVLAYEPVWAIGTGKTATPQQTQAPPCLQTPQPRAQARSPLCHLHSEEPARHLSPSPPVDITVPGTALPPPLGPSPAWRVHH

--------------------------------------------------------------
>93331_93331_12_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000535434_SMARCC2_chr12_56557549_ENST00000550164_length(transcript)=1262nt_BP=824nt
CTCGCCGGCGTCCGCGTCCCCGCGCCGAGCTGCTCGGGCTCCCTGAGCCCCAGATCTGACCCCTTCCCTTCGGCAACCTGAACGACTCCC
GCCTTCCACGGAAGGGACCGAGCCCGTGCCAAACAGGCTGAGCGATTTGGGAGTGAGGAGCCATCCTACCGCTTTCCCCAACCTGGAAAC
AGCAAAGCGCAAGGCCTCTGAGTCAGTTAGGTCTCTGCCACCCACGGGCAAAGGATGCTCTCCTCCATCCTCCTTCCTCCCTCCACCGAA
ATCGGAGAGCCGCGGGCCTGATCCAAAGAGGCATCCCCTTCTCGTTCATTCCCCAGAGGCCTCAATACAAACCCCAGGAGTTGGCCCCTC
TCCTTTTGCTACAAATCCTTGCCTTGCAAAGGGGAGAGGTGGTTTGTGCTCCCCCTACTGCCTATATCGACTTCGCCCGGCAGAAGCTAG
ATCCCAAGATTGCTGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTGGGGAGATCAGCCCTGGCATGATCAAAGACT
GCGGAGCCACGTGGGTGGTCCTGGGGCACTCAGAGAGAAGGCATGTCTTTGGGGAGTCAGATGAGCTGATTGGGCAGAAAGTGGCCCATG
CTCTGGCAGAGGGACTCGGAGTAATCGCCTGCATTGGGGAGAAGCTAGATGAAAGGGAAGCTGGCATCACTGAGAAGGTTGTTTTCGAGC
AGACAAAGGTCATCGCAGATAACGTGAAGGACTGGAGCAAGGTCGTCCTGGCCTATGAGCCTGTGTGGGCCATTGGTACTGGCAAGACTG
CAACACCCCAACAGACCCAGGCACCCCCCTGCCTCCAGACCCCACAGCCCCGAGCCCAGGCACGGTCACCCCTGTGCCACCTCCACAGTG
AGGAGCCAGCCAGACATCTCTCCCCCTCACCCCCTGTGGACATCACGGTTCCAGGAACAGCCCTTCCCCCACCACTGGGACCCTCCCCAG
CCTGGAGAGTTCATCACTACGTAAGGAAAGCTCCTTCCGCCCCTCCAAAGCCCTCACCATGCCTAACAGAGGCATGCATTTTTATATCAG
ATTATTCAAGGACTTCTGTTTAAAAGATGTTTATAATGTCTGGGAGAGAGGATAGGATGGGAATGCTGCCCTAAAGGAAGGGCTGGTGAA
AGGTGTTTATACAAGGTTCTATTAACCACTTCTAAGGGTACACCTCCCTCCAAACTACTGCATTTTCTATGGATTAAAAAAAAAAAAAAA

>93331_93331_12_TPI1-SMARCC2_TPI1_chr12_6978937_ENST00000535434_SMARCC2_chr12_56557549_ENST00000550164_length(amino acids)=301AA_BP=208
MSQLGLCHPRAKDALLHPPSSLHRNRRAAGLIQRGIPFSFIPQRPQYKPQELAPLLLLQILALQRGEVVCAPPTAYIDFARQKLDPKIAV
AAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIA
DNVKDWSKVVLAYEPVWAIGTGKTATPQQTQAPPCLQTPQPRAQARSPLCHLHSEEPARHLSPSPPVDITVPGTALPPPLGPSPAWRVHH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TPI1-SMARCC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TPI1-SMARCC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TPI1-SMARCC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource