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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TPM1-HOPX (FusionGDB2 ID:93345)

Fusion Gene Summary for TPM1-HOPX

check button Fusion gene summary
Fusion gene informationFusion gene name: TPM1-HOPX
Fusion gene ID: 93345
HgeneTgene
Gene symbol

TPM1

HOPX

Gene ID

7168

84525

Gene nametropomyosin 1HOP homeobox
SynonymsC15orf13|CMD1Y|CMH3|HEL-S-265|HTM-alpha|LVNC9|TMSACAMEO|HOD|HOP|LAGY|NECC1|OB1|SMAP31|TOTO
Cytomap

15q22.2

4q12

Type of geneprotein-codingprotein-coding
Descriptiontropomyosin alpha-1 chaincardiomyopathy, hypertrophic 3epididymis secretory protein Li 265sarcomeric tropomyosin kappahomeodomain-only proteinlung cancer-associated Y proteinnot expressed in choriocarcinoma clone 1odd homeobox protein 1
Modification date2020032020200313
UniProtAcc.

Q9BPY8

Ensembl transtripts involved in fusion geneENST00000267996, ENST00000357980, 
ENST00000358278, ENST00000404484, 
ENST00000559397, ENST00000288398, 
ENST00000317516, ENST00000334895, 
ENST00000403994, ENST00000559281, 
ENST00000559556, ENST00000560445, 
ENST00000560959, 		ENST00000317745, 
ENST00000337881, ENST00000381255, 
ENST00000381260, ENST00000420433, 
ENST00000503639, ENST00000508121, 
ENST00000553379, ENST00000554144, 
ENST00000555760, ENST00000556376, 
ENST00000556614, ENST00000605395, 
Fusion gene scores* DoF score7 X 9 X 3=1896 X 5 X 3=90
# samples 87
** MAII scorelog2(8/189*10)=-1.24031432933371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TPM1 [Title/Abstract] AND HOPX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTPM1(63363855)-HOPX(57516008), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHOPX

GO:0001829

trophectodermal cell differentiation

17576768

TgeneHOPX

GO:0045596

negative regulation of cell differentiation

17576768

TgeneHOPX

GO:0051131

chaperone-mediated protein complex assembly

10811660


check buttonFusion gene breakpoints across TPM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HOPX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW950454TPM1chr15

63363855

+HOPXchr4

57516008

-
ChiTaRS5.0N/AT28253TPM1chr15

63363855

+HOPXchr4

57516008

-


Top

Fusion Gene ORF analysis for TPM1-HOPX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000267996ENST00000317745TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000267996ENST00000337881TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000267996ENST00000381255TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000267996ENST00000381260TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000267996ENST00000420433TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000267996ENST00000503639TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000267996ENST00000508121TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000267996ENST00000553379TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000267996ENST00000554144TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000267996ENST00000555760TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000267996ENST00000556376TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000267996ENST00000556614TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000267996ENST00000605395TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000357980ENST00000317745TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000357980ENST00000337881TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000357980ENST00000381255TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000357980ENST00000381260TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000357980ENST00000420433TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000357980ENST00000503639TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000357980ENST00000508121TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000357980ENST00000553379TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000357980ENST00000554144TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000357980ENST00000555760TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000357980ENST00000556376TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000357980ENST00000556614TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000357980ENST00000605395TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000358278ENST00000317745TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000358278ENST00000337881TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000358278ENST00000381255TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000358278ENST00000381260TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000358278ENST00000420433TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000358278ENST00000503639TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000358278ENST00000508121TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000358278ENST00000553379TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000358278ENST00000554144TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000358278ENST00000555760TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000358278ENST00000556376TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000358278ENST00000556614TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000358278ENST00000605395TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000404484ENST00000317745TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000404484ENST00000337881TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000404484ENST00000381255TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000404484ENST00000381260TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000404484ENST00000420433TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000404484ENST00000503639TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000404484ENST00000508121TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000404484ENST00000553379TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000404484ENST00000554144TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000404484ENST00000555760TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000404484ENST00000556376TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000404484ENST00000556614TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000404484ENST00000605395TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000559397ENST00000317745TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000559397ENST00000337881TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000559397ENST00000381255TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000559397ENST00000381260TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000559397ENST00000420433TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000559397ENST00000503639TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000559397ENST00000508121TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000559397ENST00000553379TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000559397ENST00000554144TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000559397ENST00000555760TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000559397ENST00000556376TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000559397ENST00000556614TPM1chr15

63363855

+HOPXchr4

57516008

-
3UTR-intronENST00000559397ENST00000605395TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000288398ENST00000317745TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000288398ENST00000337881TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000288398ENST00000381255TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000288398ENST00000381260TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000288398ENST00000420433TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000288398ENST00000503639TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000288398ENST00000508121TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000288398ENST00000553379TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000288398ENST00000554144TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000288398ENST00000555760TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000288398ENST00000556376TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000288398ENST00000556614TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000288398ENST00000605395TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000317516ENST00000317745TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000317516ENST00000337881TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000317516ENST00000381255TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000317516ENST00000381260TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000317516ENST00000420433TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000317516ENST00000503639TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000317516ENST00000508121TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000317516ENST00000553379TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000317516ENST00000554144TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000317516ENST00000555760TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000317516ENST00000556376TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000317516ENST00000556614TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000317516ENST00000605395TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000334895ENST00000317745TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000334895ENST00000337881TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000334895ENST00000381255TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000334895ENST00000381260TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000334895ENST00000420433TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000334895ENST00000503639TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000334895ENST00000508121TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000334895ENST00000553379TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000334895ENST00000554144TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000334895ENST00000555760TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000334895ENST00000556376TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000334895ENST00000556614TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000334895ENST00000605395TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000403994ENST00000317745TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000403994ENST00000337881TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000403994ENST00000381255TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000403994ENST00000381260TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000403994ENST00000420433TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000403994ENST00000503639TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000403994ENST00000508121TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000403994ENST00000553379TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000403994ENST00000554144TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000403994ENST00000555760TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000403994ENST00000556376TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000403994ENST00000556614TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000403994ENST00000605395TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559281ENST00000317745TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559281ENST00000337881TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559281ENST00000381255TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559281ENST00000381260TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559281ENST00000420433TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559281ENST00000503639TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559281ENST00000508121TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559281ENST00000553379TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559281ENST00000554144TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559281ENST00000555760TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559281ENST00000556376TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559281ENST00000556614TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559281ENST00000605395TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559556ENST00000317745TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559556ENST00000337881TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559556ENST00000381255TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559556ENST00000381260TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559556ENST00000420433TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559556ENST00000503639TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559556ENST00000508121TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559556ENST00000553379TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559556ENST00000554144TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559556ENST00000555760TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559556ENST00000556376TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559556ENST00000556614TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000559556ENST00000605395TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560445ENST00000317745TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560445ENST00000337881TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560445ENST00000381255TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560445ENST00000381260TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560445ENST00000420433TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560445ENST00000503639TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560445ENST00000508121TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560445ENST00000553379TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560445ENST00000554144TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560445ENST00000555760TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560445ENST00000556376TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560445ENST00000556614TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560445ENST00000605395TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560959ENST00000317745TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560959ENST00000337881TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560959ENST00000381255TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560959ENST00000381260TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560959ENST00000420433TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560959ENST00000503639TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560959ENST00000508121TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560959ENST00000553379TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560959ENST00000554144TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560959ENST00000555760TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560959ENST00000556376TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560959ENST00000556614TPM1chr15

63363855

+HOPXchr4

57516008

-
intron-intronENST00000560959ENST00000605395TPM1chr15

63363855

+HOPXchr4

57516008

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TPM1-HOPX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TPM1-HOPX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:63363855/:57516008)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HOPX

Q9BPY8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256). {ECO:0000250|UniProtKB:Q8R1H0, ECO:0000269|PubMed:27708256}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TPM1-HOPX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TPM1-HOPX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TPM1-HOPX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TPM1-HOPX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource