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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TPM3-ALK (FusionGDB2 ID:93374)

Fusion Gene Summary for TPM3-ALK

Fusion gene summary

Fusion gene information	Fusion gene name: TPM3-ALK
	Fusion gene ID: 93374
		Hgene	Tgene
	Gene symbol	TPM3	ALK
	Gene ID	7170	238
	Gene name	tropomyosin 3	ALK receptor tyrosine kinase
	Synonyms	CAPM1\|CFTD\|HEL-189\|HEL-S-82p\|NEM1\|OK/SW-cl.5\|TM-5\|TM3\|TM30\|TM30nm\|TM5\|TPM3nu\|TPMsk3\|TRK\|hscp30	CD246\|NBLST3
	Cytomap	1q21.3	2p23.2-p23.1
	Type of gene	protein-coding	protein-coding
	Description	tropomyosin alpha-3 chainalpha-tropomyosin, slow skeletalcytoskeletal tropomyosin TM30epididymis luminal protein 189epididymis secretory sperm binding protein Li 82pheat-stable cytoskeletal protein 30 kDatropomyosin 3 nutropomyosin gammatropomyosi	ALK tyrosine kinase receptorCD246 antigenanaplastic lymphoma receptor tyrosine kinasemutant anaplastic lymphoma kinase
	Modification date	20200328	20200329
	UniProtAcc	.	Q96BT7
	Ensembl transtripts involved in fusion gene	ENST00000271850, ENST00000302206, ENST00000323144, ENST00000328159, ENST00000330188, ENST00000341372, ENST00000341485, ENST00000368530, ENST00000368531, ENST00000368533, ENST00000469717,	ENST00000389048, ENST00000431873, ENST00000498037,
Fusion gene scores	* DoF score	15 X 22 X 8=2640	56 X 74 X 20=82880
	# samples	24	57
	** MAII score	log2(24/2640*10)=-3.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(57/82880*10)=-7.18391827352181 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TPM3 [Title/Abstract] AND ALK [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TPM3(154137866)-ALK(29446396), # samples:1 TPM3(154135578)-ALK(30129881), # samples:1 TPM3(154142876)-ALK(29446402), # samples:1
Anticipated loss of major functional domain due to fusion event.	TPM3-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. TPM3-ALK seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. TPM3-ALK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. TPM3-ALK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ALK	GO:0016310	phosphorylation	9174053
Tgene	ALK	GO:0046777	protein autophosphorylation	9174053

Fusion gene breakpoints across TPM3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ALK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	anaplastic large cell lymphoma;myofibroblastic sarcoma	AF112866	TPM3	chr1	154137866		ALK	chr2	29446396
ChimerKB3	.	.	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
ChimerKB3	.	.	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
ChimerKB3	.	.	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
ChimerKB3	.	.	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
ChiTaRS5.0	N/A	AF112866	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
ChiTaRS5.0	N/A	AF362886	TPM3	chr1	154142876	-	ALK	chr2	29446402	-

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Fusion Gene ORF analysis for TPM3-ALK

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000271850	ENST00000389048	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000271850	ENST00000431873	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000271850	ENST00000431873	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000271850	ENST00000498037	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000271850	ENST00000498037	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000302206	ENST00000389048	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000302206	ENST00000431873	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000302206	ENST00000431873	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000302206	ENST00000498037	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000302206	ENST00000498037	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000323144	ENST00000389048	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000323144	ENST00000431873	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000323144	ENST00000431873	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000323144	ENST00000498037	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000323144	ENST00000498037	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000328159	ENST00000389048	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000328159	ENST00000431873	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000328159	ENST00000431873	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000328159	ENST00000498037	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000328159	ENST00000498037	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000330188	ENST00000389048	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000330188	ENST00000431873	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000330188	ENST00000431873	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000330188	ENST00000498037	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000330188	ENST00000498037	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000341372	ENST00000389048	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000341372	ENST00000431873	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000341372	ENST00000431873	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000341372	ENST00000498037	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000341372	ENST00000498037	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000341485	ENST00000389048	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000341485	ENST00000431873	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000341485	ENST00000431873	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000341485	ENST00000498037	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000341485	ENST00000498037	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000368530	ENST00000389048	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000368530	ENST00000431873	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000368530	ENST00000431873	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000368530	ENST00000498037	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000368530	ENST00000498037	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000368531	ENST00000389048	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000368531	ENST00000431873	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000368531	ENST00000431873	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000368531	ENST00000498037	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000368531	ENST00000498037	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000368533	ENST00000389048	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000368533	ENST00000431873	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000368533	ENST00000431873	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5CDS-intron	ENST00000368533	ENST00000498037	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5CDS-intron	ENST00000368533	ENST00000498037	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5UTR-3CDS	ENST00000469717	ENST00000389048	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5UTR-intron	ENST00000469717	ENST00000389048	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5UTR-intron	ENST00000469717	ENST00000431873	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5UTR-intron	ENST00000469717	ENST00000431873	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
5UTR-intron	ENST00000469717	ENST00000498037	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
5UTR-intron	ENST00000469717	ENST00000498037	TPM3	chr1	154142876	-	ALK	chr2	29446402	-
Frame-shift	ENST00000271850	ENST00000389048	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
Frame-shift	ENST00000323144	ENST00000389048	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
Frame-shift	ENST00000328159	ENST00000389048	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
Frame-shift	ENST00000330188	ENST00000389048	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
Frame-shift	ENST00000341372	ENST00000389048	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
Frame-shift	ENST00000341485	ENST00000389048	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
Frame-shift	ENST00000368530	ENST00000389048	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
Frame-shift	ENST00000368531	ENST00000389048	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
Frame-shift	ENST00000368533	ENST00000389048	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
In-frame	ENST00000302206	ENST00000389048	TPM3	chr1	154143124	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000271850	ENST00000389048	TPM3	chr1	154137866		ALK	chr2	29446396
intron-3CDS	ENST00000271850	ENST00000389048	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000271850	ENST00000389048	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000271850	ENST00000389048	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-3CDS	ENST00000302206	ENST00000389048	TPM3	chr1	154137866		ALK	chr2	29446396
intron-3CDS	ENST00000302206	ENST00000389048	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000302206	ENST00000389048	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000302206	ENST00000389048	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-3CDS	ENST00000323144	ENST00000389048	TPM3	chr1	154137866		ALK	chr2	29446396
intron-3CDS	ENST00000323144	ENST00000389048	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000323144	ENST00000389048	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000323144	ENST00000389048	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-3CDS	ENST00000328159	ENST00000389048	TPM3	chr1	154137866		ALK	chr2	29446396
intron-3CDS	ENST00000328159	ENST00000389048	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000328159	ENST00000389048	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000328159	ENST00000389048	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-3CDS	ENST00000330188	ENST00000389048	TPM3	chr1	154137866		ALK	chr2	29446396
intron-3CDS	ENST00000330188	ENST00000389048	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000330188	ENST00000389048	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000330188	ENST00000389048	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-3CDS	ENST00000341372	ENST00000389048	TPM3	chr1	154137866		ALK	chr2	29446396
intron-3CDS	ENST00000341372	ENST00000389048	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000341372	ENST00000389048	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000341372	ENST00000389048	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-3CDS	ENST00000341485	ENST00000389048	TPM3	chr1	154137866		ALK	chr2	29446396
intron-3CDS	ENST00000341485	ENST00000389048	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000341485	ENST00000389048	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000341485	ENST00000389048	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-3CDS	ENST00000368530	ENST00000389048	TPM3	chr1	154137866		ALK	chr2	29446396
intron-3CDS	ENST00000368530	ENST00000389048	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000368530	ENST00000389048	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000368530	ENST00000389048	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-3CDS	ENST00000368531	ENST00000389048	TPM3	chr1	154137866		ALK	chr2	29446396
intron-3CDS	ENST00000368531	ENST00000389048	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000368531	ENST00000389048	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000368531	ENST00000389048	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-3CDS	ENST00000368533	ENST00000389048	TPM3	chr1	154137866		ALK	chr2	29446396
intron-3CDS	ENST00000368533	ENST00000389048	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000368533	ENST00000389048	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000368533	ENST00000389048	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-3CDS	ENST00000469717	ENST00000389048	TPM3	chr1	154137866		ALK	chr2	29446396
intron-3CDS	ENST00000469717	ENST00000389048	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000469717	ENST00000389048	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-3CDS	ENST00000469717	ENST00000389048	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000271850	ENST00000389048	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000271850	ENST00000431873	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000271850	ENST00000431873	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000271850	ENST00000431873	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000271850	ENST00000431873	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000271850	ENST00000431873	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000271850	ENST00000498037	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000271850	ENST00000498037	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000271850	ENST00000498037	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000271850	ENST00000498037	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000271850	ENST00000498037	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000302206	ENST00000389048	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000302206	ENST00000431873	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000302206	ENST00000431873	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000302206	ENST00000431873	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000302206	ENST00000431873	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000302206	ENST00000431873	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000302206	ENST00000498037	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000302206	ENST00000498037	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000302206	ENST00000498037	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000302206	ENST00000498037	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000302206	ENST00000498037	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000323144	ENST00000389048	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000323144	ENST00000431873	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000323144	ENST00000431873	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000323144	ENST00000431873	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000323144	ENST00000431873	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000323144	ENST00000431873	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000323144	ENST00000498037	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000323144	ENST00000498037	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000323144	ENST00000498037	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000323144	ENST00000498037	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000323144	ENST00000498037	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000328159	ENST00000389048	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000328159	ENST00000431873	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000328159	ENST00000431873	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000328159	ENST00000431873	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000328159	ENST00000431873	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000328159	ENST00000431873	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000328159	ENST00000498037	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000328159	ENST00000498037	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000328159	ENST00000498037	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000328159	ENST00000498037	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000328159	ENST00000498037	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000330188	ENST00000389048	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000330188	ENST00000431873	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000330188	ENST00000431873	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000330188	ENST00000431873	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000330188	ENST00000431873	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000330188	ENST00000431873	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000330188	ENST00000498037	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000330188	ENST00000498037	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000330188	ENST00000498037	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000330188	ENST00000498037	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000330188	ENST00000498037	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000341372	ENST00000389048	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000341372	ENST00000431873	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000341372	ENST00000431873	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000341372	ENST00000431873	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000341372	ENST00000431873	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000341372	ENST00000431873	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000341372	ENST00000498037	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000341372	ENST00000498037	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000341372	ENST00000498037	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000341372	ENST00000498037	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000341372	ENST00000498037	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000341485	ENST00000389048	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000341485	ENST00000431873	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000341485	ENST00000431873	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000341485	ENST00000431873	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000341485	ENST00000431873	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000341485	ENST00000431873	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000341485	ENST00000498037	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000341485	ENST00000498037	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000341485	ENST00000498037	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000341485	ENST00000498037	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000341485	ENST00000498037	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000368530	ENST00000389048	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000368530	ENST00000431873	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000368530	ENST00000431873	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000368530	ENST00000431873	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000368530	ENST00000431873	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000368530	ENST00000431873	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000368530	ENST00000498037	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000368530	ENST00000498037	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000368530	ENST00000498037	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000368530	ENST00000498037	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000368530	ENST00000498037	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000368531	ENST00000389048	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000368531	ENST00000431873	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000368531	ENST00000431873	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000368531	ENST00000431873	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000368531	ENST00000431873	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000368531	ENST00000431873	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000368531	ENST00000498037	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000368531	ENST00000498037	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000368531	ENST00000498037	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000368531	ENST00000498037	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000368531	ENST00000498037	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000368533	ENST00000389048	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000368533	ENST00000431873	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000368533	ENST00000431873	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000368533	ENST00000431873	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000368533	ENST00000431873	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000368533	ENST00000431873	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000368533	ENST00000498037	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000368533	ENST00000498037	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000368533	ENST00000498037	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000368533	ENST00000498037	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000368533	ENST00000498037	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000469717	ENST00000389048	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000469717	ENST00000431873	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000469717	ENST00000431873	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000469717	ENST00000431873	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000469717	ENST00000431873	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000469717	ENST00000431873	TPM3	chr1	154135578	-	ALK	chr2	30129881	-
intron-intron	ENST00000469717	ENST00000498037	TPM3	chr1	154137866		ALK	chr2	29446396
intron-intron	ENST00000469717	ENST00000498037	TPM3	chr1	154131444	-	ALK	chr2	29446394	-
intron-intron	ENST00000469717	ENST00000498037	TPM3	chr1	154134289	-	ALK	chr2	29446394	-
intron-intron	ENST00000469717	ENST00000498037	TPM3	chr1	154144580	-	ALK	chr2	29446307	-
intron-intron	ENST00000469717	ENST00000498037	TPM3	chr1	154135578	-	ALK	chr2	30129881	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000302206

TPM3

chr1

154143124

ENST00000389048

ALK

chr2

29446394

2673

532

555

2222

555

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for TPM3-ALK

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TPM3-ALK

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:154137866/chr2:29446396)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ALK Q96BT7
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). {ECO:0000269\|PubMed:19293182, ECO:0000269\|PubMed:20123966, ECO:0000269\|PubMed:20308323, ECO:0000269\|PubMed:21285950, ECO:0000269\|PubMed:31079898}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for TPM3-ALK

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>93374_93374_1_TPM3-ALK_TPM3_chr1_154143124_ENST00000302206_ALK_chr2_29446394_ENST00000389048_length(transcript)=2673nt_BP=532nt
GGTGAGCTGCATGATGTCTTACATTTCATGAGCTTCCTCTAAATCTAGTTGTATTTTTCGTCTGAGGGGGGCTGAGGCTGAGGTGGCCTC
CTTGAACCGTAGGATCCAGCTGGTTGAAGAAGAGCTGGACCGTGCTCAGGAGCGCCTGGCCACTGCCCTGCAAAAGCTGGAAGAAGCTGA
AAAAGCTGCTGATGAGAGTGAGAGAGGTATGAAGGTTATTGAAAACCGGGCCTTAAAAGATGAAGAAAAGATGGAACTCCAGGAAATCCA
ACTCAAAGAAGCTAAGCACATTGCAGAAGAGGCAGATAGGAAGTATGAAGAGGTGGCTCGTAAGTTGGTGATCATTGAAGGAGACTTGGA
ACGCACAGAGGAACGAGCTGAGCTGGCAGAGTCTAAGTGTTCTGAGCTGGAGGAGGAGCTGAAGAATGTCACCAACAACCTCAAGTCTCT
TGAGGCTCAGGCGGAGAAGTACTCTCAAAAAGAAGATAAATATGAGGAAGAAATCAAGATTCTTACTGATAAACTCAAGGAGTGTACCGC
CGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTACAAGCTGAGCAAGCTCCGCACCTCGACCATCATGACC
GACTACAACCCCAACTACTGCTTTGCTGGCAAGACCTCCTCCATCAGTGACCTGAAGGAGGTGCCGCGGAAAAACATCACCCTCATTCGG
GGTCTGGGCCATGGCGCCTTTGGGGAGGTGTATGAAGGCCAGGTGTCCGGAATGCCCAACGACCCAAGCCCCCTGCAAGTGGCTGTGAAG
ACGCTGCCTGAAGTGTGCTCTGAACAGGACGAACTGGATTTCCTCATGGAAGCCCTGATCATCAGCAAATTCAACCACCAGAACATTGTT
CGCTGCATTGGGGTGAGCCTGCAATCCCTGCCCCGGTTCATCCTGCTGGAGCTCATGGCGGGGGGAGACCTCAAGTCCTTCCTCCGAGAG
ACCCGCCCTCGCCCGAGCCAGCCCTCCTCCCTGGCCATGCTGGACCTTCTGCACGTGGCTCGGGACATTGCCTGTGGCTGTCAGTATTTG
GAGGAAAACCACTTCATCCACCGAGACATTGCTGCCAGAAACTGCCTCTTGACCTGTCCAGGCCCTGGAAGAGTGGCCAAGATTGGAGAC
TTCGGGATGGCCCGAGACATCTACAGGGCGAGCTACTATAGAAAGGGAGGCTGTGCCATGCTGCCAGTTAAGTGGATGCCCCCAGAGGCC
TTCATGGAAGGAATATTCACTTCTAAAACAGACACATGGTCCTTTGGAGTGCTGCTATGGGAAATCTTTTCTCTTGGATATATGCCATAC
CCCAGCAAAAGCAACCAGGAAGTTCTGGAGTTTGTCACCAGTGGAGGCCGGATGGACCCACCCAAGAACTGCCCTGGGCCTGTATACCGG
ATAATGACTCAGTGCTGGCAACATCAGCCTGAAGACAGGCCCAACTTTGCCATCATTTTGGAGAGGATTGAATACTGCACCCAGGACCCG
GATGTAATCAACACCGCTTTGCCGATAGAATATGGTCCACTTGTGGAAGAGGAAGAGAAAGTGCCTGTGAGGCCCAAGGACCCTGAGGGG
GTTCCTCCTCTCCTGGTCTCTCAACAGGCAAAACGGGAGGAGGAGCGCAGCCCAGCTGCCCCACCACCTCTGCCTACCACCTCCTCTGGC
AAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTCCCTAGAGGGCCGGCCGTGGAAGGGGGACACGTGAATATGGCATTC
TCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCCAGAAACAAGCCCACCAGCTTGTGGAACCCAACGTACGGCTCCTGG
TTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAGGAGCCACACGACAGGGGTAACCTGGGGCTGGAGGGAAGCTGTACT
GTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTGCTCCTAGAGCCCTCTTCGCTGACTGCCAATATGAAGGAGGTACCT
CTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGCTACCAGCAACAGGGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGA
GCTGGTCATTACGAGGATACCATTCTGAAAAGCAAGAATAGCATGAACCAGCCTGGGCCCTGAGCTCGGTCGCACACTCACTTCTCTTCC
TTGGGATCCCTAAGACCGTGGAGGAGAGAGAGGCAATGGCTCCTTCACAAACCAGAGACCAAATGTCACGTTTTGTTTTGTGCCAACCTA
TTTTGAAGTACCACCAAAAAAGCTGTATTTTGAAAATGCTTTAGAAAGGTTTTGAGCATGGGTTCATCCTATTCTTTCGAAAGAAGAAAA
TATCATAAAAATGAGTGATAAATACAAGGCCCAGATGTGGTTGCATAAGGTTTTTATGCATGTTTGTTGTATACTTCCTTATGCTTCTTT
CAAATTGTGTGTGCTCTGCTTCAATGTAGTCAGAATTAGCTGCTTCTATGTTTCATAGTTGGGGTCATAGATGTTTCCTTGCCTTGTTGA

>93374_93374_1_TPM3-ALK_TPM3_chr1_154143124_ENST00000302206_ALK_chr2_29446394_ENST00000389048_length(amino acids)=555AA_BP=
MQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEV
CSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHF
IHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSN
QEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLL
VSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKP
TKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TPM3-ALK

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TPM3-ALK

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TPM3-ALK

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source