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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BCL2L11-ACOXL (FusionGDB2 ID:9339)

Fusion Gene Summary for BCL2L11-ACOXL

check button Fusion gene summary
Fusion gene informationFusion gene name: BCL2L11-ACOXL
Fusion gene ID: 9339
HgeneTgene
Gene symbol

BCL2L11

ACOXL

Gene ID

10018

55289

Gene nameBCL2 like 11acyl-CoA oxidase like
SynonymsBAM|BIM|BOD-
Cytomap

2q13

2q13

Type of geneprotein-codingprotein-coding
Descriptionbcl-2-like protein 11BCL2-like 11 (apoptosis facilitator)bcl-2 interacting mediator of cell deathbcl-2 interacting protein Bimbcl-2-related ovarian death agonistacyl-coenzyme A oxidase-like proteinacyl-CoA oxidase-like protein
Modification date2020031320200313
UniProtAcc

O43521

Q9NUZ1

Ensembl transtripts involved in fusion geneENST00000308659, ENST00000337565, 
ENST00000357757, ENST00000393253, 
ENST00000393256, ENST00000405953, 
ENST00000340561, ENST00000389811, 
ENST00000439055, ENST00000496981, 
Fusion gene scores* DoF score7 X 4 X 6=1682 X 2 X 2=8
# samples 93
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: BCL2L11 [Title/Abstract] AND ACOXL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBCL2L11(111881716)-ACOXL(111875193), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBCL2L11

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

11546872

HgeneBCL2L11

GO:0031334

positive regulation of protein complex assembly

21041309

HgeneBCL2L11

GO:0034976

response to endoplasmic reticulum stress

22761832

HgeneBCL2L11

GO:2000271

positive regulation of fibroblast apoptotic process

11997495


check buttonFusion gene breakpoints across BCL2L11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ACOXL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0RS-01ABCL2L11chr2

111881716

-ACOXLchr2

111875193

+
ChimerDB4BRCATCGA-B6-A0RS-01ABCL2L11chr2

111881716

+ACOXLchr2

111875193

+
ChimerDB4LUSCTCGA-46-6025-01ABCL2L11chr2

111881716

-ACOXLchr2

111875193

+
ChimerDB4LUSCTCGA-46-6025BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
ChimerDB4LUSCTCGA-46-6025BCL2L11chr2

111881716

+ACOXLchr2

111875193

+


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Fusion Gene ORF analysis for BCL2L11-ACOXL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000308659ENST00000340561BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000308659ENST00000340561BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000308659ENST00000389811BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000308659ENST00000389811BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000308659ENST00000439055BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000308659ENST00000439055BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000308659ENST00000496981BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000308659ENST00000496981BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000337565ENST00000340561BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000337565ENST00000340561BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000337565ENST00000389811BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000337565ENST00000389811BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000337565ENST00000439055BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000337565ENST00000439055BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000337565ENST00000496981BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000337565ENST00000496981BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000357757ENST00000340561BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000357757ENST00000340561BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000357757ENST00000389811BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000357757ENST00000389811BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000357757ENST00000439055BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000357757ENST00000439055BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000357757ENST00000496981BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000357757ENST00000496981BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000393253ENST00000340561BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000393253ENST00000389811BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000393253ENST00000439055BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000393253ENST00000496981BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000393256ENST00000340561BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000393256ENST00000340561BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000393256ENST00000389811BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000393256ENST00000389811BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000393256ENST00000439055BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000393256ENST00000439055BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000393256ENST00000496981BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000393256ENST00000496981BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000405953ENST00000340561BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000405953ENST00000340561BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000405953ENST00000389811BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000405953ENST00000389811BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000405953ENST00000439055BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000405953ENST00000439055BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
5CDS-intronENST00000405953ENST00000496981BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
5CDS-intronENST00000405953ENST00000496981BCL2L11chr2

111881446

+ACOXLchr2

111875193

+
intron-intronENST00000393253ENST00000340561BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
intron-intronENST00000393253ENST00000389811BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
intron-intronENST00000393253ENST00000439055BCL2L11chr2

111881716

+ACOXLchr2

111875193

+
intron-intronENST00000393253ENST00000496981BCL2L11chr2

111881716

+ACOXLchr2

111875193

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for BCL2L11-ACOXL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BCL2L11chr2111881446+ACOXLchr2111875192+0.0081726210.99182737
BCL2L11chr2111881716+ACOXLchr2111875192+0.0008427810.9991572
BCL2L11chr2111881446+ACOXLchr2111875192+0.0081726210.99182737
BCL2L11chr2111881716+ACOXLchr2111875192+0.0008427810.9991572

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BCL2L11-ACOXL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:111881716/:111875193)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCL2L11

O43521

ACOXL

Q9NUZ1

FUNCTION: Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:9430630}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for BCL2L11-ACOXL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for BCL2L11-ACOXL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BCL2L11-ACOXL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BCL2L11-ACOXL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource