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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:TPM4-GPR37L1 (FusionGDB2 ID:93402) |
Fusion Gene Summary for TPM4-GPR37L1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TPM4-GPR37L1 | Fusion gene ID: 93402 | Hgene | Tgene | Gene symbol | TPM4 | GPR37L1 | Gene ID | 7171 | 9283 |
| Gene name | tropomyosin 4 | G protein-coupled receptor 37 like 1 | |
| Synonyms | HEL-S-108 | ET(B)R-LP-2|ETBR-LP-2|ETBRLP2 | |
| Cytomap | 19p13.12-p13.11 | 1q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tropomyosin alpha-4 chainTM30p1epididymis secretory protein Li 108 | G-protein coupled receptor 37-like 1endothelin B receptor-like protein 2endothelin type b receptor-like protein 2prosaposin receptor GPR37L1 | |
| Modification date | 20200320 | 20200313 | |
| UniProtAcc | . | O60883 | |
| Ensembl transtripts involved in fusion gene | ENST00000591645, ENST00000300933, ENST00000344824, ENST00000538887, | ENST00000367282, | |
| Fusion gene scores | * DoF score | 22 X 19 X 9=3762 | 12 X 6 X 7=504 |
| # samples | 25 | 16 | |
| ** MAII score | log2(25/3762*10)=-3.91149984886111 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/504*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TPM4 [Title/Abstract] AND GPR37L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | TPM4(16204563)-GPR37L1(202096868), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GPR37L1 | GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 23690594 |
| Tgene | GPR37L1 | GO:0043410 | positive regulation of MAPK cascade | 23690594 |
| Fusion gene breakpoints across TPM4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across GPR37L1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | UCEC | TCGA-D1-A16R | TPM4 | chr19 | 16204563 | + | GPR37L1 | chr1 | 202096868 | + |
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Fusion Gene ORF analysis for TPM4-GPR37L1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000591645 | ENST00000367282 | TPM4 | chr19 | 16204563 | + | GPR37L1 | chr1 | 202096868 | + |
| In-frame | ENST00000300933 | ENST00000367282 | TPM4 | chr19 | 16204563 | + | GPR37L1 | chr1 | 202096868 | + |
| In-frame | ENST00000344824 | ENST00000367282 | TPM4 | chr19 | 16204563 | + | GPR37L1 | chr1 | 202096868 | + |
| In-frame | ENST00000538887 | ENST00000367282 | TPM4 | chr19 | 16204563 | + | GPR37L1 | chr1 | 202096868 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000344824 | TPM4 | chr19 | 16204563 | + | ENST00000367282 | GPR37L1 | chr1 | 202096868 | + | 6742 | 890 | 821 | 1705 | 294 |
| ENST00000538887 | TPM4 | chr19 | 16204563 | + | ENST00000367282 | GPR37L1 | chr1 | 202096868 | + | 6711 | 859 | 790 | 1674 | 294 |
| ENST00000300933 | TPM4 | chr19 | 16204563 | + | ENST00000367282 | GPR37L1 | chr1 | 202096868 | + | 6776 | 924 | 29 | 973 | 314 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000344824 | ENST00000367282 | TPM4 | chr19 | 16204563 | + | GPR37L1 | chr1 | 202096868 | + | 0.17931116 | 0.82068884 |
| ENST00000538887 | ENST00000367282 | TPM4 | chr19 | 16204563 | + | GPR37L1 | chr1 | 202096868 | + | 0.18004645 | 0.8199535 |
| ENST00000300933 | ENST00000367282 | TPM4 | chr19 | 16204563 | + | GPR37L1 | chr1 | 202096868 | + | 0.17465234 | 0.8253476 |
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Fusion Genomic Features for TPM4-GPR37L1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| TPM4 | chr19 | 16204563 | + | GPR37L1 | chr1 | 202096868 | + | 6.32E-12 | 1 |
| TPM4 | chr19 | 16204563 | + | GPR37L1 | chr1 | 202096868 | + | 6.32E-12 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TPM4-GPR37L1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:16204563/chr1:202096868) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | GPR37L1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity). {ECO:0000250|UniProtKB:Q99JG2, ECO:0000269|PubMed:23690594, ECO:0000269|PubMed:27072655, ECO:0000269|PubMed:28688853}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TPM4 | chr19:16204563 | chr1:202096868 | ENST00000344824 | + | 8 | 9 | 2_248 | 257 | 285.0 | Coiled coil | Ontology_term=ECO:0000250 |
| Hgene | TPM4 | chr19:16204563 | chr1:202096868 | ENST00000538887 | + | 8 | 10 | 2_248 | 257 | 270.0 | Coiled coil | Ontology_term=ECO:0000250 |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 418_439 | 210 | 482.0 | Compositional bias | Note=Cys-rich | |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 227_251 | 210 | 482.0 | Topological domain | Cytoplasmic | |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 273_310 | 210 | 482.0 | Topological domain | Extracellular | |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 332_361 | 210 | 482.0 | Topological domain | Cytoplasmic | |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 383_398 | 210 | 482.0 | Topological domain | Extracellular | |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 420_481 | 210 | 482.0 | Topological domain | Cytoplasmic | |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 252_272 | 210 | 482.0 | Transmembrane | Helical%3B Name%3D4 | |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 311_331 | 210 | 482.0 | Transmembrane | Helical%3B Name%3D5 | |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 362_382 | 210 | 482.0 | Transmembrane | Helical%3B Name%3D6 | |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 399_419 | 210 | 482.0 | Transmembrane | Helical%3B Name%3D7 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TPM4 | chr19:16204563 | chr1:202096868 | ENST00000300933 | + | 7 | 8 | 2_248 | 221 | 249.0 | Coiled coil | Ontology_term=ECO:0000250 |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 156_167 | 210 | 482.0 | Topological domain | Cytoplasmic | |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 189_205 | 210 | 482.0 | Topological domain | Extracellular | |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 26_134 | 210 | 482.0 | Topological domain | Extracellular | |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 135_155 | 210 | 482.0 | Transmembrane | Helical%3B Name%3D1 | |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 168_188 | 210 | 482.0 | Transmembrane | Helical%3B Name%3D2 | |
| Tgene | GPR37L1 | chr19:16204563 | chr1:202096868 | ENST00000367282 | 0 | 2 | 206_226 | 210 | 482.0 | Transmembrane | Helical%3B Name%3D3 |
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Fusion Gene Sequence for TPM4-GPR37L1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >93402_93402_1_TPM4-GPR37L1_TPM4_chr19_16204563_ENST00000300933_GPR37L1_chr1_202096868_ENST00000367282_length(transcript)=6776nt_BP=924nt AAGTCCCGAAAAGGGGCACTTTCCAGCAGCTGTGGCCAGCGGTGCCGACGTCAGGCCCTCCCCCAGCGGTGCTGACGTCGGCGGTCCGGC CGGGTGACCTCATCGCCCCGACGGCAGCCGGCCCGGGGGGCGGGGAGAGGCGGGGGCGGCCCCCGCGCAGGCAAAGGCTTGGGGGGCCGG GGCGCGGCTGTGCAGCTCTCGCCGGAGCCGAGCCCAGCCGAGCGTCCGCCGCTGCCCGTGCGCCTCTGCGCCTCCGCGCCATGGCCGGCC TCAACTCCCTGGAGGCGGTGAAACGCAAGATCCAGGCCCTGCAGCAGCAGGCGGACGAGGCGGAAGACCGCGCGCAGGGCCTGCAGCGGG AGCTGGACGGCGAGCGCGAGCGGCGCGAGAAAGCTGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGG ACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCAGAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGA TAGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAAGAGGCTGACC GCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAAT GTGGTGACCTGGAAGAAGAACTCAAGAATGTTACTAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGTATTCTGAAAAGGAGGACA AATATGAAGAAGAAATTAAACTTCTGTCTGACAAACTGAAAGAGGCTGAGACCCGTGCTGAATTTGCAGAGAGAACGGTTGCAAAACTGG AAAAGACAATTGATGACCTGGAAGGTCTCCTCTCTGGGAGTCACGACTTTCAGCCTCTGTGCCCTGGGCATTGACCGCTTCCACGTGGCC ACCAGCACCCTGCCCAAGGTGAGGCCCATCGAGCGGTGCCAATCCATCCTGGCCAAGTTGGCTGTCATCTGGGTGGGCTCCATGACGCTG GCTGTGCCTGAGCTCCTGCTGTGGCAGCTGGCACAGGAGCCTGCCCCCACCATGGGCACCCTGGACTCATGCATCATGAAACCCTCAGCC AGCCTGCCCGAGTCCCTGTATTCACTGGTGATGACCTACCAGAACGCCCGCATGTGGTGGTACTTTGGCTGCTACTTCTGCCTGCCCATC CTCTTCACAGTCACCTGCCAGCTGGTGACATGGCGGGTGCGAGGCCCTCCAGGGAGGAAGTCAGAGTGCAGGGCCAGCAAGCACGAGCAG TGTGAGAGCCAGCTCAACAGCACCGTGGTGGGCCTGACCGTGGTCTACGCCTTCTGCACCCTCCCAGAGAACGTCTGCAACATCGTGGTG GCCTACCTCTCCACCGAGCTGACCCGCCAGACCCTGGACCTCCTGGGCCTCATCAACCAGTTCTCCACCTTCTTCAAGGGCGCCATCACC CCAGTGCTGCTCCTTTGCATCTGCAGGCCGCTGGGCCAGGCCTTCCTGGACTGCTGCTGCTGCTGCTGCTGTGAGGAGTGCGGCGGGGCT TCGGAGGCCTCTGCTGCCAATGGGTCGGACAACAAGCTCAAGACCGAGGTGTCCTCTTCCATCTACTTCCACAAGCCCAGGGAGTCACCC CCACTCCTGCCCCTGGGCACACCTTGCTGAGGCCCCAGTAGGGGTGGGGAGGGAGGGAGAGGCCGCCACCCCCGCCGGTGTCTGCTGTTC TTTCCCCATAGGTCTTGCTTTGTTGCCTGTCTTGCTGTCTAGGGATGGACTTGGTTCCTCTTGTCAAGGTTTGGGAATGTCAAAGCCCCC TCCCCACACAGGGCCTTTCCTGTCCCTTGTGGGGCCTTCCAACCCTGTCCTTTCCACTGGTGGGCGGTGATGCTTCTAGGTCCTTAGAAC TGCCCAGAAACTCTGAGTCCCAGCAGCTGGGAGCCAGAACTTTGCCTGCCCTCCCTTGGTTCCAGTCTCTCTTCTCTCTCTCTGCCTTGG AACCTGACCATACTTTAGTTGTGCCCTTCCCAGGCATCATCCTCCTACCACCAACCTGGGGCCCCATCTTGGAATGGGGGCTCCTTGGGG CCAGCCCAGTGTGGCTCACCACACTCTTCTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTACATT TGCCTGATGTCAGCTCCCTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGTG CACCAACACACCCGGCTAATTTTTGTATTTGTAGAAGAGGCGGGGTTTCACCATGTTGGCCAGGCTGGTGTTGAACTCCTGACCTCAAGT GATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTGCCACGCCCAGCCCCAGTACACTCTTCTCTGGACCAGATCT GTCCCAGTCCTGGATGCCTCCTCCTACTGGTGCCTTCTTTTCTTCCAGAGGATTTCTCTCTCCTTCCTCCTCCTTTCTTTGGGATCCCTG GGTTGCCCTGTCCCAACCTCCTTGTTAGGTGCTTTCCCATAGGAGGCCCTTCTTGAGAAACAATAAACTAGGTAGAACTACCCCTATGCC CATCCACTTTCTTGTGCCACATTCTGGCAGGGCCCAGATGCAGCTGGGCCTTCCTGGCCTGGCAGTGCCTAGGAGAATTTCTCCTGACCT GGCCTGGCCTGTGGCTGATGTTCAGAACAGCCTTGTGGCCGATGTTCAGAACAGCCTTGTGGCCCTGGCGACTCCAAGGGTTTTATGGCT TTTGAGGGACAGAGAGGATGGAGGGCTTGGGGAGCCGGAGGACCTAAGTCCTCATCCTGGCCTAAACCCCATGCTCCTTGGGAAGTCAAA AGCCTGGAAAATATCTCCTCTGGAGCCTTCATCTCTGCTATGCCCTCTCTCCACAAAGCCCCCCTTGGAGGGAGTCCAGTGGTCTTTCCT CTGTGAGCCCCAGGGCTTCCCAGCCTTTGTCACTCTGAGAGCTGCTCTTGTTCAGTTTCTTAGAATGGACTGTTTTGCCTGTAGACGGCC CAGCTGCCTGCCCTGGCCTGCCCCCACCCAGCCCCCACTGCACCACCCTTCCCGCCAGAGCTCCCACTGCCCCCGGCAGACCCTTCATGC AGCTTCTCCTGTGGGGTCTTGCCCTTGAAGTGCCACTTCCCCCAGCCCCACCTCTGGTCCCTTCCAGAGGGCACCCTTAGCCTTGTAGGT CCCTGGGAAGCTGGCACAGCATCAACCAGAAGTGATGCCTCAGCCAGGCCACCAGTCGCTCCCCGCCTGGGAGCTCAGCTTTCCTCAGAA CCACCCCCCCTGTCTGAAGCTCTGTCCTGGGTCCCACCAGACTTCTGCCCACCAGGCCTACCTACAGCATCCACATGGGGCCTCAGGAAG GGCCCCGGGGGCCCAGGGATGGGCAGGGGCAGGGTTTCCAAGCGCCTGGGGCTCCATTCTCCTCTGTCCACCCACCCACACCCCTTGGCC TCAGCCTGCCCTGTACCCAAGCTTCCCTCCCCCTCTCCTGGGGATCTTAACGGCCTTGTTCTCTCTCCCTGGCACCCACCCCCAGGGCGG GTGATGCCGCCAAGAGAGAGGGAGGCCGTTGCTAGGTGATGGCGCCGCCATGCACACACCCTTTGTGCTGGGGAGTGACACCCACCCGTT TCTCAGCAGACCTGTTGCCACGGTGACTGAAGCCCCCAGCTCTGTCTGTAGAAACTTCAGATGGGTGGGGGAGCAGGTTGGAGAGGGGAC CAAAGGCAGGCCTGTCGTGCTGAAGCTCTTGGGGACCGTTTCCTCGGCATTTCCCCAACTCCTTCTCCACCCCCCTGCCAGGCCCGGAAG TACCACCAGCTTCCTAAGGGATGCAGGAAGGGGCCGGGTGAACTGAGGTGAAGTCCAGGGCAGGGGAGTCAGACCCCTCAACATCCTGTT TAGGGGTCCTCCTCCACAAAGGGTGCCCTCCACCTCTCCCTCCTGCTGGTTGGCCGGCTCAGAGATGAAGGGGGAGAGATGGTGGCTCCA AGGCTCTGCCACCGCCACCTCCCAAGCCTGCCAACGTGAATGGCTTGCAGAATCAGTCAGCAGGCCAGCGGCCTTGGGAAAGAGCCACTG TCCTCGCAGCCTGGGCCAGCTGGGGGAACAATGTAGGGTTTGTTGCTTAGGGGTCCCAGGCTTGCGGGGGGGTTGGCACATGGTGGGCAG TGGACTTGAGCTGGGATGGTCTGAGGGGGCACTGACACGCTCACCCGAGGGCAGACTTCAGACCAGCCCTCAGATCCTGATGCCAGGTTA CAGGGCTGAGGGGAGCCTGAAATCCACTGGGTCTCCCTGCTCCACTTGGGAGTCACCTTCTCATCACCTATCCTGGAACTGAATGCAATT ACTTAAACTCAGTCTCAGCTTCCTCATCTGTAAAATGGGAATAATCTGTCCTTCACAGAGGATTATGGTCATTTAATGAGACAAGATACA TAAAGCACTTTGCATGGTGCCCCGAACCTTTTATTCCTTCCTCTCCTTTGGGAATTCAATTCTCTAGTGTTAGGAGCAGGCTTGGCCCAG GGATTCTTAAATGCATCCAGGTTTTGGCATCAAAGGGCCCCAAACATGACAATTTACCTATACTCATGGTCTGTTCCCATTCAACTTTAA TAGGTTATGTGTGTTTTTTTTTTCTTAAGAGCTGGGTGGGGGGGTCTCACTATGTTGCCCAGGCTGGCTTTGAACTCCTGGGCTCAAGCA GTCCTCCTGTCTCAGCCTCCTGAGTAGCTGGGACTACAAGTGTGTACCACCATGCCTGGCTGAACACTTTTTTTTTTTTGAGACAAGATC CCACTCAGTCACTCAAGCTGAGTGCTGTGGTGTGATCACAGCTCATTGCAGCCTCCACTTCCTGGGCTCAAGCGATTCTCCTGCCTCAGC TTCCTGAGTAGCTGGGACTACAGGTGCGCACTACCACGCCTGTCTAATTTTTGATTATTTGTAGAGATAGGGTCTCACTATTTTGCCCAG GCTGGTCTCAAACTCCCAGACTCAAGTCATTCTCCTACCTCGGGCTCCCAAAGTACTGGGATTACAGGCATGAGCACCTGGCCCCTGAAC AAATTCTTTAAGTCATATTAGCACCTGCTGCACGCCGGCACTGTGGAAGGAGGATGCTTGCTTGCTTCCTGGTAACCAGCTCTCTTATCT CAAACCTCAATCCTCAGTGAGGATCACAGGATCTGAGAAAGGCACCTTGGCCTGGAAACAGCCCCAGATGAGTGAGATTGCTGGTCCTCT CCCGGGATCCCAGGCCCAGGAAAACCTAGCCATGCTTGCAGTCAGGAGAGGGCAGGGGATAGAGCCCTGGCTCCCATTCAACCTCCTTAG CCAGGAGGACATGTCCCATTTTGCTTAGGAGTTGGGAGGTACCCTAGAATCACTTAGCTTCAGATGCCAAATTCCATCCACATTCTTTCC TCCAACTCTCTGGCAGTGGGGAACTGCCTCTCCAGGCAGGGAACTGCTCTGACAGGTCTGATGACTGCCTCCAGGAGGAAGCCCTGGGCA CCAATGAAGGTGAGGGGCTGGAGGGCCCAGGACGGGGAGTCAAGGTCCCCACTCCCAGGACTAAGGGACAGTTTGGCTCCTTTTTCCTGC AGTGGGAGGGGTGAGAAGGGCTGGGGTGTTCTGCAAGGGCCTGCTCCATTTTCCAGGGTGAAGGAGAGGCCGAGGGAGGTGGAGCGGGAG GAGGTGGGGCTTACTGTGAAACTGGGTCAAGATGGCCTCGGATTTGAGCAGGCAGGGTCACCAGGCTCTGAGGCAGCAGCTGTGAGCAGT GCCGAGGGAGGACCAGCTCTGACGGTGAGGTCGGGTGGGGGACTAGAATCCAGCAGAGGAGCGAGGGCAGGGCTCCTACCAGGAAACCCA TAGCATTGACACTAACTGAGAGGCAGCAAAGGCGGTGACACTCCCCCAGGCTCTGTGGGCCCAGCCCTACCCCTGAAGCACAGTTAACTG GTTCTGGGGTAGGAACTGGGGGCCGGAGGGACAGGGTTCTGGTTCTGGCTCAACCTTGGCTGCTGGTGAGATCCAGGGCCTGGGAAAGAG GGGCTGAGGCCTGAACTGGGCCTAAGGAGAGTGCAGCTCAGTTCGCACACAACAGCACCCAGCCCTGTCCCCTTGCTGCCTCTACCCAGC CCTGGGCAGTTCCCTCAACAGAGCTCTGCAGCCCCAAGTGGCAGCTGCTGGCTCAAAGCTGGGACTACATGAAAGTCTGAAAAGAGAATG AGAAGGAGGTGGCGCAAGAGCCTGGACGCACGTGTGGGAGGCCGTTTTGTGCAGCGCCATTGTGCTCCCCGGGCGGGCATGTGCTCGCGC TCCGTGGCTCTGTTGGTGCCCAGCGTGCGGGGGTGTGCTGGTGGCCCTGTGGGCCTGTAGGGCAACCCATGCCAACTGCGGAAAAGTAAC CAGCACCATACACCCCCCCCAACACAAAACTGGTCATTTATTTTTTTTGTTGTCATTGTTATTAGGAAGCAAAAAAATGTACAGTTACAA GAATCATTTTCCAAACAGAGGTTAAATATGAGCTGAAAAGTGTAAAAAAGGAAGAGGAACATCACTTTACAAATCATTAAATTAAACAAA >93402_93402_1_TPM4-GPR37L1_TPM4_chr19_16204563_ENST00000300933_GPR37L1_chr1_202096868_ENST00000367282_length(amino acids)=314AA_BP=298 MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLS -------------------------------------------------------------- >93402_93402_2_TPM4-GPR37L1_TPM4_chr19_16204563_ENST00000344824_GPR37L1_chr1_202096868_ENST00000367282_length(transcript)=6742nt_BP=890nt ATAAGGCCCTCTCCTCCACCCTGCCAGGCTCACTCTGCCCCACAGCCACAGCCCCTGACTGCCGCAGCCCCCACAGAGCCCGCCGCGCAC CCCACGTCCCCCACGCCAGCGCCCAGCCATGGAGGCCATCAAGAAGAAAATGCAGATGCTGAAGTTGGACAAGGAGAATGCCATCGACCG CGCGGAGCAGGCGGAGGCGGATAAGAAAGCCGCTGAGGACAAGTGCAAGCAGGTGGAGGAGGAGCTGACGCACCTCCAGAAGAAACTAAA AGGGACAGAGGACGAGCTGGATAAATATTCCGAGGACCTGAAGGACGCGCAGGAGAAGCTGGAGCTCACGGAGAAGAAGGCCTCCGACGC TGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCA GAAGCTGGAGGAGGCAGAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGAAGAT GGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCAT CCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAGAATGTTAC TAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGTATTCTGAAAAGGAGGACAAATATGAAGAAGAAATTAAACTTCTGTCTGACAA ACTGAAAGAGGCTGAGACCCGTGCTGAATTTGCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTGGAAGGTCTCCTCTC TGGGAGTCACGACTTTCAGCCTCTGTGCCCTGGGCATTGACCGCTTCCACGTGGCCACCAGCACCCTGCCCAAGGTGAGGCCCATCGAGC GGTGCCAATCCATCCTGGCCAAGTTGGCTGTCATCTGGGTGGGCTCCATGACGCTGGCTGTGCCTGAGCTCCTGCTGTGGCAGCTGGCAC AGGAGCCTGCCCCCACCATGGGCACCCTGGACTCATGCATCATGAAACCCTCAGCCAGCCTGCCCGAGTCCCTGTATTCACTGGTGATGA CCTACCAGAACGCCCGCATGTGGTGGTACTTTGGCTGCTACTTCTGCCTGCCCATCCTCTTCACAGTCACCTGCCAGCTGGTGACATGGC GGGTGCGAGGCCCTCCAGGGAGGAAGTCAGAGTGCAGGGCCAGCAAGCACGAGCAGTGTGAGAGCCAGCTCAACAGCACCGTGGTGGGCC TGACCGTGGTCTACGCCTTCTGCACCCTCCCAGAGAACGTCTGCAACATCGTGGTGGCCTACCTCTCCACCGAGCTGACCCGCCAGACCC TGGACCTCCTGGGCCTCATCAACCAGTTCTCCACCTTCTTCAAGGGCGCCATCACCCCAGTGCTGCTCCTTTGCATCTGCAGGCCGCTGG GCCAGGCCTTCCTGGACTGCTGCTGCTGCTGCTGCTGTGAGGAGTGCGGCGGGGCTTCGGAGGCCTCTGCTGCCAATGGGTCGGACAACA AGCTCAAGACCGAGGTGTCCTCTTCCATCTACTTCCACAAGCCCAGGGAGTCACCCCCACTCCTGCCCCTGGGCACACCTTGCTGAGGCC CCAGTAGGGGTGGGGAGGGAGGGAGAGGCCGCCACCCCCGCCGGTGTCTGCTGTTCTTTCCCCATAGGTCTTGCTTTGTTGCCTGTCTTG CTGTCTAGGGATGGACTTGGTTCCTCTTGTCAAGGTTTGGGAATGTCAAAGCCCCCTCCCCACACAGGGCCTTTCCTGTCCCTTGTGGGG CCTTCCAACCCTGTCCTTTCCACTGGTGGGCGGTGATGCTTCTAGGTCCTTAGAACTGCCCAGAAACTCTGAGTCCCAGCAGCTGGGAGC CAGAACTTTGCCTGCCCTCCCTTGGTTCCAGTCTCTCTTCTCTCTCTCTGCCTTGGAACCTGACCATACTTTAGTTGTGCCCTTCCCAGG CATCATCCTCCTACCACCAACCTGGGGCCCCATCTTGGAATGGGGGCTCCTTGGGGCCAGCCCAGTGTGGCTCACCACACTCTTCTTTTT TTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTACATTTGCCTGATGTCAGCTCCCTGCAACCTCCGCCTCC TGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGTGCACCAACACACCCGGCTAATTTTTGTATTTGTAG AAGAGGCGGGGTTTCACCATGTTGGCCAGGCTGGTGTTGAACTCCTGACCTCAAGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGA TTACAGGTGTGAGCTGCCACGCCCAGCCCCAGTACACTCTTCTCTGGACCAGATCTGTCCCAGTCCTGGATGCCTCCTCCTACTGGTGCC TTCTTTTCTTCCAGAGGATTTCTCTCTCCTTCCTCCTCCTTTCTTTGGGATCCCTGGGTTGCCCTGTCCCAACCTCCTTGTTAGGTGCTT TCCCATAGGAGGCCCTTCTTGAGAAACAATAAACTAGGTAGAACTACCCCTATGCCCATCCACTTTCTTGTGCCACATTCTGGCAGGGCC CAGATGCAGCTGGGCCTTCCTGGCCTGGCAGTGCCTAGGAGAATTTCTCCTGACCTGGCCTGGCCTGTGGCTGATGTTCAGAACAGCCTT GTGGCCGATGTTCAGAACAGCCTTGTGGCCCTGGCGACTCCAAGGGTTTTATGGCTTTTGAGGGACAGAGAGGATGGAGGGCTTGGGGAG CCGGAGGACCTAAGTCCTCATCCTGGCCTAAACCCCATGCTCCTTGGGAAGTCAAAAGCCTGGAAAATATCTCCTCTGGAGCCTTCATCT CTGCTATGCCCTCTCTCCACAAAGCCCCCCTTGGAGGGAGTCCAGTGGTCTTTCCTCTGTGAGCCCCAGGGCTTCCCAGCCTTTGTCACT CTGAGAGCTGCTCTTGTTCAGTTTCTTAGAATGGACTGTTTTGCCTGTAGACGGCCCAGCTGCCTGCCCTGGCCTGCCCCCACCCAGCCC CCACTGCACCACCCTTCCCGCCAGAGCTCCCACTGCCCCCGGCAGACCCTTCATGCAGCTTCTCCTGTGGGGTCTTGCCCTTGAAGTGCC ACTTCCCCCAGCCCCACCTCTGGTCCCTTCCAGAGGGCACCCTTAGCCTTGTAGGTCCCTGGGAAGCTGGCACAGCATCAACCAGAAGTG ATGCCTCAGCCAGGCCACCAGTCGCTCCCCGCCTGGGAGCTCAGCTTTCCTCAGAACCACCCCCCCTGTCTGAAGCTCTGTCCTGGGTCC CACCAGACTTCTGCCCACCAGGCCTACCTACAGCATCCACATGGGGCCTCAGGAAGGGCCCCGGGGGCCCAGGGATGGGCAGGGGCAGGG TTTCCAAGCGCCTGGGGCTCCATTCTCCTCTGTCCACCCACCCACACCCCTTGGCCTCAGCCTGCCCTGTACCCAAGCTTCCCTCCCCCT CTCCTGGGGATCTTAACGGCCTTGTTCTCTCTCCCTGGCACCCACCCCCAGGGCGGGTGATGCCGCCAAGAGAGAGGGAGGCCGTTGCTA GGTGATGGCGCCGCCATGCACACACCCTTTGTGCTGGGGAGTGACACCCACCCGTTTCTCAGCAGACCTGTTGCCACGGTGACTGAAGCC CCCAGCTCTGTCTGTAGAAACTTCAGATGGGTGGGGGAGCAGGTTGGAGAGGGGACCAAAGGCAGGCCTGTCGTGCTGAAGCTCTTGGGG ACCGTTTCCTCGGCATTTCCCCAACTCCTTCTCCACCCCCCTGCCAGGCCCGGAAGTACCACCAGCTTCCTAAGGGATGCAGGAAGGGGC CGGGTGAACTGAGGTGAAGTCCAGGGCAGGGGAGTCAGACCCCTCAACATCCTGTTTAGGGGTCCTCCTCCACAAAGGGTGCCCTCCACC TCTCCCTCCTGCTGGTTGGCCGGCTCAGAGATGAAGGGGGAGAGATGGTGGCTCCAAGGCTCTGCCACCGCCACCTCCCAAGCCTGCCAA CGTGAATGGCTTGCAGAATCAGTCAGCAGGCCAGCGGCCTTGGGAAAGAGCCACTGTCCTCGCAGCCTGGGCCAGCTGGGGGAACAATGT AGGGTTTGTTGCTTAGGGGTCCCAGGCTTGCGGGGGGGTTGGCACATGGTGGGCAGTGGACTTGAGCTGGGATGGTCTGAGGGGGCACTG ACACGCTCACCCGAGGGCAGACTTCAGACCAGCCCTCAGATCCTGATGCCAGGTTACAGGGCTGAGGGGAGCCTGAAATCCACTGGGTCT CCCTGCTCCACTTGGGAGTCACCTTCTCATCACCTATCCTGGAACTGAATGCAATTACTTAAACTCAGTCTCAGCTTCCTCATCTGTAAA ATGGGAATAATCTGTCCTTCACAGAGGATTATGGTCATTTAATGAGACAAGATACATAAAGCACTTTGCATGGTGCCCCGAACCTTTTAT TCCTTCCTCTCCTTTGGGAATTCAATTCTCTAGTGTTAGGAGCAGGCTTGGCCCAGGGATTCTTAAATGCATCCAGGTTTTGGCATCAAA GGGCCCCAAACATGACAATTTACCTATACTCATGGTCTGTTCCCATTCAACTTTAATAGGTTATGTGTGTTTTTTTTTTCTTAAGAGCTG GGTGGGGGGGTCTCACTATGTTGCCCAGGCTGGCTTTGAACTCCTGGGCTCAAGCAGTCCTCCTGTCTCAGCCTCCTGAGTAGCTGGGAC TACAAGTGTGTACCACCATGCCTGGCTGAACACTTTTTTTTTTTTGAGACAAGATCCCACTCAGTCACTCAAGCTGAGTGCTGTGGTGTG ATCACAGCTCATTGCAGCCTCCACTTCCTGGGCTCAAGCGATTCTCCTGCCTCAGCTTCCTGAGTAGCTGGGACTACAGGTGCGCACTAC CACGCCTGTCTAATTTTTGATTATTTGTAGAGATAGGGTCTCACTATTTTGCCCAGGCTGGTCTCAAACTCCCAGACTCAAGTCATTCTC CTACCTCGGGCTCCCAAAGTACTGGGATTACAGGCATGAGCACCTGGCCCCTGAACAAATTCTTTAAGTCATATTAGCACCTGCTGCACG CCGGCACTGTGGAAGGAGGATGCTTGCTTGCTTCCTGGTAACCAGCTCTCTTATCTCAAACCTCAATCCTCAGTGAGGATCACAGGATCT GAGAAAGGCACCTTGGCCTGGAAACAGCCCCAGATGAGTGAGATTGCTGGTCCTCTCCCGGGATCCCAGGCCCAGGAAAACCTAGCCATG CTTGCAGTCAGGAGAGGGCAGGGGATAGAGCCCTGGCTCCCATTCAACCTCCTTAGCCAGGAGGACATGTCCCATTTTGCTTAGGAGTTG GGAGGTACCCTAGAATCACTTAGCTTCAGATGCCAAATTCCATCCACATTCTTTCCTCCAACTCTCTGGCAGTGGGGAACTGCCTCTCCA GGCAGGGAACTGCTCTGACAGGTCTGATGACTGCCTCCAGGAGGAAGCCCTGGGCACCAATGAAGGTGAGGGGCTGGAGGGCCCAGGACG GGGAGTCAAGGTCCCCACTCCCAGGACTAAGGGACAGTTTGGCTCCTTTTTCCTGCAGTGGGAGGGGTGAGAAGGGCTGGGGTGTTCTGC AAGGGCCTGCTCCATTTTCCAGGGTGAAGGAGAGGCCGAGGGAGGTGGAGCGGGAGGAGGTGGGGCTTACTGTGAAACTGGGTCAAGATG GCCTCGGATTTGAGCAGGCAGGGTCACCAGGCTCTGAGGCAGCAGCTGTGAGCAGTGCCGAGGGAGGACCAGCTCTGACGGTGAGGTCGG GTGGGGGACTAGAATCCAGCAGAGGAGCGAGGGCAGGGCTCCTACCAGGAAACCCATAGCATTGACACTAACTGAGAGGCAGCAAAGGCG GTGACACTCCCCCAGGCTCTGTGGGCCCAGCCCTACCCCTGAAGCACAGTTAACTGGTTCTGGGGTAGGAACTGGGGGCCGGAGGGACAG GGTTCTGGTTCTGGCTCAACCTTGGCTGCTGGTGAGATCCAGGGCCTGGGAAAGAGGGGCTGAGGCCTGAACTGGGCCTAAGGAGAGTGC AGCTCAGTTCGCACACAACAGCACCCAGCCCTGTCCCCTTGCTGCCTCTACCCAGCCCTGGGCAGTTCCCTCAACAGAGCTCTGCAGCCC CAAGTGGCAGCTGCTGGCTCAAAGCTGGGACTACATGAAAGTCTGAAAAGAGAATGAGAAGGAGGTGGCGCAAGAGCCTGGACGCACGTG TGGGAGGCCGTTTTGTGCAGCGCCATTGTGCTCCCCGGGCGGGCATGTGCTCGCGCTCCGTGGCTCTGTTGGTGCCCAGCGTGCGGGGGT GTGCTGGTGGCCCTGTGGGCCTGTAGGGCAACCCATGCCAACTGCGGAAAAGTAACCAGCACCATACACCCCCCCCAACACAAAACTGGT CATTTATTTTTTTTGTTGTCATTGTTATTAGGAAGCAAAAAAATGTACAGTTACAAGAATCATTTTCCAAACAGAGGTTAAATATGAGCT >93402_93402_2_TPM4-GPR37L1_TPM4_chr19_16204563_ENST00000344824_GPR37L1_chr1_202096868_ENST00000367282_length(amino acids)=294AA_BP=23 MRPVLNLQRERLQNWKRQLMTWKVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPA PTMGTLDSCIMKPSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKSECRASKHEQCESQLNSTVVGLTVV YAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKT -------------------------------------------------------------- >93402_93402_3_TPM4-GPR37L1_TPM4_chr19_16204563_ENST00000538887_GPR37L1_chr1_202096868_ENST00000367282_length(transcript)=6711nt_BP=859nt ACTCTGCCCCACAGCCACAGCCCCTGACTGCCGCAGCCCCCACAGAGCCCGCCGCGCACCCCACGTCCCCCACGCCAGCGCCCAGCCATG GAGGCCATCAAGAAGAAAATGCAGATGCTGAAGTTGGACAAGGAGAATGCCATCGACCGCGCGGAGCAGGCGGAGGCGGATAAGAAAGCC GCTGAGGACAAGTGCAAGCAGGTGGAGGAGGAGCTGACGCACCTCCAGAAGAAACTAAAAGGGACAGAGGACGAGCTGGATAAATATTCC GAGGACCTGAAGGACGCGCAGGAGAAGCTGGAGCTCACGGAGAAGAAGGCCTCCGACGCTGAAGGTGATGTGGCCGCCCTCAACCGACGC ATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCAGAAAAAGCTGCAGAT GAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCC AAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAG CGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAGAATGTTACTAACAATCTGAAATCTCTGGAGGCTGCATCT GAAAAGTATTCTGAAAAGGAGGACAAATATGAAGAAGAAATTAAACTTCTGTCTGACAAACTGAAAGAGGCTGAGACCCGTGCTGAATTT GCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTGGAAGGTCTCCTCTCTGGGAGTCACGACTTTCAGCCTCTGTGCCCT GGGCATTGACCGCTTCCACGTGGCCACCAGCACCCTGCCCAAGGTGAGGCCCATCGAGCGGTGCCAATCCATCCTGGCCAAGTTGGCTGT CATCTGGGTGGGCTCCATGACGCTGGCTGTGCCTGAGCTCCTGCTGTGGCAGCTGGCACAGGAGCCTGCCCCCACCATGGGCACCCTGGA CTCATGCATCATGAAACCCTCAGCCAGCCTGCCCGAGTCCCTGTATTCACTGGTGATGACCTACCAGAACGCCCGCATGTGGTGGTACTT TGGCTGCTACTTCTGCCTGCCCATCCTCTTCACAGTCACCTGCCAGCTGGTGACATGGCGGGTGCGAGGCCCTCCAGGGAGGAAGTCAGA GTGCAGGGCCAGCAAGCACGAGCAGTGTGAGAGCCAGCTCAACAGCACCGTGGTGGGCCTGACCGTGGTCTACGCCTTCTGCACCCTCCC AGAGAACGTCTGCAACATCGTGGTGGCCTACCTCTCCACCGAGCTGACCCGCCAGACCCTGGACCTCCTGGGCCTCATCAACCAGTTCTC CACCTTCTTCAAGGGCGCCATCACCCCAGTGCTGCTCCTTTGCATCTGCAGGCCGCTGGGCCAGGCCTTCCTGGACTGCTGCTGCTGCTG CTGCTGTGAGGAGTGCGGCGGGGCTTCGGAGGCCTCTGCTGCCAATGGGTCGGACAACAAGCTCAAGACCGAGGTGTCCTCTTCCATCTA CTTCCACAAGCCCAGGGAGTCACCCCCACTCCTGCCCCTGGGCACACCTTGCTGAGGCCCCAGTAGGGGTGGGGAGGGAGGGAGAGGCCG CCACCCCCGCCGGTGTCTGCTGTTCTTTCCCCATAGGTCTTGCTTTGTTGCCTGTCTTGCTGTCTAGGGATGGACTTGGTTCCTCTTGTC AAGGTTTGGGAATGTCAAAGCCCCCTCCCCACACAGGGCCTTTCCTGTCCCTTGTGGGGCCTTCCAACCCTGTCCTTTCCACTGGTGGGC GGTGATGCTTCTAGGTCCTTAGAACTGCCCAGAAACTCTGAGTCCCAGCAGCTGGGAGCCAGAACTTTGCCTGCCCTCCCTTGGTTCCAG TCTCTCTTCTCTCTCTCTGCCTTGGAACCTGACCATACTTTAGTTGTGCCCTTCCCAGGCATCATCCTCCTACCACCAACCTGGGGCCCC ATCTTGGAATGGGGGCTCCTTGGGGCCAGCCCAGTGTGGCTCACCACACTCTTCTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGC TCTGTTGCCCAGGCTGGAGTACATTTGCCTGATGTCAGCTCCCTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTC CTGAGTAGCTGGGATTACAGGTGTGCACCAACACACCCGGCTAATTTTTGTATTTGTAGAAGAGGCGGGGTTTCACCATGTTGGCCAGGC TGGTGTTGAACTCCTGACCTCAAGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTGCCACGCCCAGCCCCA GTACACTCTTCTCTGGACCAGATCTGTCCCAGTCCTGGATGCCTCCTCCTACTGGTGCCTTCTTTTCTTCCAGAGGATTTCTCTCTCCTT CCTCCTCCTTTCTTTGGGATCCCTGGGTTGCCCTGTCCCAACCTCCTTGTTAGGTGCTTTCCCATAGGAGGCCCTTCTTGAGAAACAATA AACTAGGTAGAACTACCCCTATGCCCATCCACTTTCTTGTGCCACATTCTGGCAGGGCCCAGATGCAGCTGGGCCTTCCTGGCCTGGCAG TGCCTAGGAGAATTTCTCCTGACCTGGCCTGGCCTGTGGCTGATGTTCAGAACAGCCTTGTGGCCGATGTTCAGAACAGCCTTGTGGCCC TGGCGACTCCAAGGGTTTTATGGCTTTTGAGGGACAGAGAGGATGGAGGGCTTGGGGAGCCGGAGGACCTAAGTCCTCATCCTGGCCTAA ACCCCATGCTCCTTGGGAAGTCAAAAGCCTGGAAAATATCTCCTCTGGAGCCTTCATCTCTGCTATGCCCTCTCTCCACAAAGCCCCCCT TGGAGGGAGTCCAGTGGTCTTTCCTCTGTGAGCCCCAGGGCTTCCCAGCCTTTGTCACTCTGAGAGCTGCTCTTGTTCAGTTTCTTAGAA TGGACTGTTTTGCCTGTAGACGGCCCAGCTGCCTGCCCTGGCCTGCCCCCACCCAGCCCCCACTGCACCACCCTTCCCGCCAGAGCTCCC ACTGCCCCCGGCAGACCCTTCATGCAGCTTCTCCTGTGGGGTCTTGCCCTTGAAGTGCCACTTCCCCCAGCCCCACCTCTGGTCCCTTCC AGAGGGCACCCTTAGCCTTGTAGGTCCCTGGGAAGCTGGCACAGCATCAACCAGAAGTGATGCCTCAGCCAGGCCACCAGTCGCTCCCCG CCTGGGAGCTCAGCTTTCCTCAGAACCACCCCCCCTGTCTGAAGCTCTGTCCTGGGTCCCACCAGACTTCTGCCCACCAGGCCTACCTAC AGCATCCACATGGGGCCTCAGGAAGGGCCCCGGGGGCCCAGGGATGGGCAGGGGCAGGGTTTCCAAGCGCCTGGGGCTCCATTCTCCTCT GTCCACCCACCCACACCCCTTGGCCTCAGCCTGCCCTGTACCCAAGCTTCCCTCCCCCTCTCCTGGGGATCTTAACGGCCTTGTTCTCTC TCCCTGGCACCCACCCCCAGGGCGGGTGATGCCGCCAAGAGAGAGGGAGGCCGTTGCTAGGTGATGGCGCCGCCATGCACACACCCTTTG TGCTGGGGAGTGACACCCACCCGTTTCTCAGCAGACCTGTTGCCACGGTGACTGAAGCCCCCAGCTCTGTCTGTAGAAACTTCAGATGGG TGGGGGAGCAGGTTGGAGAGGGGACCAAAGGCAGGCCTGTCGTGCTGAAGCTCTTGGGGACCGTTTCCTCGGCATTTCCCCAACTCCTTC TCCACCCCCCTGCCAGGCCCGGAAGTACCACCAGCTTCCTAAGGGATGCAGGAAGGGGCCGGGTGAACTGAGGTGAAGTCCAGGGCAGGG GAGTCAGACCCCTCAACATCCTGTTTAGGGGTCCTCCTCCACAAAGGGTGCCCTCCACCTCTCCCTCCTGCTGGTTGGCCGGCTCAGAGA TGAAGGGGGAGAGATGGTGGCTCCAAGGCTCTGCCACCGCCACCTCCCAAGCCTGCCAACGTGAATGGCTTGCAGAATCAGTCAGCAGGC CAGCGGCCTTGGGAAAGAGCCACTGTCCTCGCAGCCTGGGCCAGCTGGGGGAACAATGTAGGGTTTGTTGCTTAGGGGTCCCAGGCTTGC GGGGGGGTTGGCACATGGTGGGCAGTGGACTTGAGCTGGGATGGTCTGAGGGGGCACTGACACGCTCACCCGAGGGCAGACTTCAGACCA GCCCTCAGATCCTGATGCCAGGTTACAGGGCTGAGGGGAGCCTGAAATCCACTGGGTCTCCCTGCTCCACTTGGGAGTCACCTTCTCATC ACCTATCCTGGAACTGAATGCAATTACTTAAACTCAGTCTCAGCTTCCTCATCTGTAAAATGGGAATAATCTGTCCTTCACAGAGGATTA TGGTCATTTAATGAGACAAGATACATAAAGCACTTTGCATGGTGCCCCGAACCTTTTATTCCTTCCTCTCCTTTGGGAATTCAATTCTCT AGTGTTAGGAGCAGGCTTGGCCCAGGGATTCTTAAATGCATCCAGGTTTTGGCATCAAAGGGCCCCAAACATGACAATTTACCTATACTC ATGGTCTGTTCCCATTCAACTTTAATAGGTTATGTGTGTTTTTTTTTTCTTAAGAGCTGGGTGGGGGGGTCTCACTATGTTGCCCAGGCT GGCTTTGAACTCCTGGGCTCAAGCAGTCCTCCTGTCTCAGCCTCCTGAGTAGCTGGGACTACAAGTGTGTACCACCATGCCTGGCTGAAC ACTTTTTTTTTTTTGAGACAAGATCCCACTCAGTCACTCAAGCTGAGTGCTGTGGTGTGATCACAGCTCATTGCAGCCTCCACTTCCTGG GCTCAAGCGATTCTCCTGCCTCAGCTTCCTGAGTAGCTGGGACTACAGGTGCGCACTACCACGCCTGTCTAATTTTTGATTATTTGTAGA GATAGGGTCTCACTATTTTGCCCAGGCTGGTCTCAAACTCCCAGACTCAAGTCATTCTCCTACCTCGGGCTCCCAAAGTACTGGGATTAC AGGCATGAGCACCTGGCCCCTGAACAAATTCTTTAAGTCATATTAGCACCTGCTGCACGCCGGCACTGTGGAAGGAGGATGCTTGCTTGC TTCCTGGTAACCAGCTCTCTTATCTCAAACCTCAATCCTCAGTGAGGATCACAGGATCTGAGAAAGGCACCTTGGCCTGGAAACAGCCCC AGATGAGTGAGATTGCTGGTCCTCTCCCGGGATCCCAGGCCCAGGAAAACCTAGCCATGCTTGCAGTCAGGAGAGGGCAGGGGATAGAGC CCTGGCTCCCATTCAACCTCCTTAGCCAGGAGGACATGTCCCATTTTGCTTAGGAGTTGGGAGGTACCCTAGAATCACTTAGCTTCAGAT GCCAAATTCCATCCACATTCTTTCCTCCAACTCTCTGGCAGTGGGGAACTGCCTCTCCAGGCAGGGAACTGCTCTGACAGGTCTGATGAC TGCCTCCAGGAGGAAGCCCTGGGCACCAATGAAGGTGAGGGGCTGGAGGGCCCAGGACGGGGAGTCAAGGTCCCCACTCCCAGGACTAAG GGACAGTTTGGCTCCTTTTTCCTGCAGTGGGAGGGGTGAGAAGGGCTGGGGTGTTCTGCAAGGGCCTGCTCCATTTTCCAGGGTGAAGGA GAGGCCGAGGGAGGTGGAGCGGGAGGAGGTGGGGCTTACTGTGAAACTGGGTCAAGATGGCCTCGGATTTGAGCAGGCAGGGTCACCAGG CTCTGAGGCAGCAGCTGTGAGCAGTGCCGAGGGAGGACCAGCTCTGACGGTGAGGTCGGGTGGGGGACTAGAATCCAGCAGAGGAGCGAG GGCAGGGCTCCTACCAGGAAACCCATAGCATTGACACTAACTGAGAGGCAGCAAAGGCGGTGACACTCCCCCAGGCTCTGTGGGCCCAGC CCTACCCCTGAAGCACAGTTAACTGGTTCTGGGGTAGGAACTGGGGGCCGGAGGGACAGGGTTCTGGTTCTGGCTCAACCTTGGCTGCTG GTGAGATCCAGGGCCTGGGAAAGAGGGGCTGAGGCCTGAACTGGGCCTAAGGAGAGTGCAGCTCAGTTCGCACACAACAGCACCCAGCCC TGTCCCCTTGCTGCCTCTACCCAGCCCTGGGCAGTTCCCTCAACAGAGCTCTGCAGCCCCAAGTGGCAGCTGCTGGCTCAAAGCTGGGAC TACATGAAAGTCTGAAAAGAGAATGAGAAGGAGGTGGCGCAAGAGCCTGGACGCACGTGTGGGAGGCCGTTTTGTGCAGCGCCATTGTGC TCCCCGGGCGGGCATGTGCTCGCGCTCCGTGGCTCTGTTGGTGCCCAGCGTGCGGGGGTGTGCTGGTGGCCCTGTGGGCCTGTAGGGCAA CCCATGCCAACTGCGGAAAAGTAACCAGCACCATACACCCCCCCCAACACAAAACTGGTCATTTATTTTTTTTGTTGTCATTGTTATTAG GAAGCAAAAAAATGTACAGTTACAAGAATCATTTTCCAAACAGAGGTTAAATATGAGCTGAAAAGTGTAAAAAAGGAAGAGGAACATCAC >93402_93402_3_TPM4-GPR37L1_TPM4_chr19_16204563_ENST00000538887_GPR37L1_chr1_202096868_ENST00000367282_length(amino acids)=294AA_BP=23 MRPVLNLQRERLQNWKRQLMTWKVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPA PTMGTLDSCIMKPSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKSECRASKHEQCESQLNSTVVGLTVV YAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TPM4-GPR37L1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TPM4-GPR37L1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TPM4-GPR37L1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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