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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TPM4-RPL18A (FusionGDB2 ID:93413)

Fusion Gene Summary for TPM4-RPL18A

check button Fusion gene summary
Fusion gene informationFusion gene name: TPM4-RPL18A
Fusion gene ID: 93413
HgeneTgene
Gene symbol

TPM4

RPL18A

Gene ID

7171

6142

Gene nametropomyosin 4ribosomal protein L18a
SynonymsHEL-S-108L18A
Cytomap

19p13.12-p13.11

19p13.11

Type of geneprotein-codingprotein-coding
Descriptiontropomyosin alpha-4 chainTM30p1epididymis secretory protein Li 10860S ribosomal protein L18alarge ribosomal subunit protein eL20ribosomal protein L18a-like protein
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000300933, ENST00000344824, 
ENST00000538887, ENST00000591645, 
ENST00000599870, ENST00000222247, 
ENST00000599898, ENST00000600147, 
Fusion gene scores* DoF score22 X 19 X 9=37625 X 6 X 4=120
# samples 256
** MAII scorelog2(25/3762*10)=-3.91149984886111
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TPM4 [Title/Abstract] AND RPL18A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTPM4(16199930)-RPL18A(17972102), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPL18A

GO:0002181

cytoplasmic translation

25957688


check buttonFusion gene breakpoints across TPM4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPL18A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-20-0991-01ATPM4chr19

16199930

+RPL18Achr19

17972102

+


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Fusion Gene ORF analysis for TPM4-RPL18A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000300933ENST00000599870TPM4chr19

16199930

+RPL18Achr19

17972102

+
5CDS-5UTRENST00000344824ENST00000599870TPM4chr19

16199930

+RPL18Achr19

17972102

+
5CDS-5UTRENST00000538887ENST00000599870TPM4chr19

16199930

+RPL18Achr19

17972102

+
In-frameENST00000300933ENST00000222247TPM4chr19

16199930

+RPL18Achr19

17972102

+
In-frameENST00000300933ENST00000599898TPM4chr19

16199930

+RPL18Achr19

17972102

+
In-frameENST00000300933ENST00000600147TPM4chr19

16199930

+RPL18Achr19

17972102

+
In-frameENST00000344824ENST00000222247TPM4chr19

16199930

+RPL18Achr19

17972102

+
In-frameENST00000344824ENST00000599898TPM4chr19

16199930

+RPL18Achr19

17972102

+
In-frameENST00000344824ENST00000600147TPM4chr19

16199930

+RPL18Achr19

17972102

+
In-frameENST00000538887ENST00000222247TPM4chr19

16199930

+RPL18Achr19

17972102

+
In-frameENST00000538887ENST00000599898TPM4chr19

16199930

+RPL18Achr19

17972102

+
In-frameENST00000538887ENST00000600147TPM4chr19

16199930

+RPL18Achr19

17972102

+
intron-3CDSENST00000591645ENST00000222247TPM4chr19

16199930

+RPL18Achr19

17972102

+
intron-3CDSENST00000591645ENST00000599898TPM4chr19

16199930

+RPL18Achr19

17972102

+
intron-3CDSENST00000591645ENST00000600147TPM4chr19

16199930

+RPL18Achr19

17972102

+
intron-5UTRENST00000591645ENST00000599870TPM4chr19

16199930

+RPL18Achr19

17972102

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344824TPM4chr1916199930+ENST00000222247RPL18Achr1917972102+1323757581269403
ENST00000344824TPM4chr1916199930+ENST00000600147RPL18Achr1917972102+2094757581203381
ENST00000344824TPM4chr1916199930+ENST00000599898RPL18Achr1917972102+1205757581152364
ENST00000538887TPM4chr1916199930+ENST00000222247RPL18Achr1917972102+1292726271238403
ENST00000538887TPM4chr1916199930+ENST00000600147RPL18Achr1917972102+2063726271172381
ENST00000538887TPM4chr1916199930+ENST00000599898RPL18Achr1917972102+1174726271121364
ENST00000300933TPM4chr1916199930+ENST00000222247RPL18Achr1917972102+1357791291303424
ENST00000300933TPM4chr1916199930+ENST00000600147RPL18Achr1917972102+2128791291237402
ENST00000300933TPM4chr1916199930+ENST00000599898RPL18Achr1917972102+1239791291186385

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344824ENST00000222247TPM4chr1916199930+RPL18Achr1917972102+0.0074890860.9925109
ENST00000344824ENST00000600147TPM4chr1916199930+RPL18Achr1917972102+0.0066769170.993323
ENST00000344824ENST00000599898TPM4chr1916199930+RPL18Achr1917972102+0.0039738420.99602616
ENST00000538887ENST00000222247TPM4chr1916199930+RPL18Achr1917972102+0.0081165940.9918834
ENST00000538887ENST00000600147TPM4chr1916199930+RPL18Achr1917972102+0.0063984440.9936015
ENST00000538887ENST00000599898TPM4chr1916199930+RPL18Achr1917972102+0.0043043380.9956956
ENST00000300933ENST00000222247TPM4chr1916199930+RPL18Achr1917972102+0.0073992240.99260074
ENST00000300933ENST00000600147TPM4chr1916199930+RPL18Achr1917972102+0.0064943830.9935056
ENST00000300933ENST00000599898TPM4chr1916199930+RPL18Achr1917972102+0.0039824220.9960175

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Fusion Genomic Features for TPM4-RPL18A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TPM4chr1916199930+RPL18Achr1917972101+9.64E-050.99990356
TPM4chr1916199930+RPL18Achr1917972101+9.64E-050.99990356

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TPM4-RPL18A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:16199930/chr19:17972102)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTPM4chr19:16199930chr19:17972102ENST00000300933+582_248177249.0Coiled coilOntology_term=ECO:0000250
HgeneTPM4chr19:16199930chr19:17972102ENST00000344824+692_248213285.0Coiled coilOntology_term=ECO:0000250
HgeneTPM4chr19:16199930chr19:17972102ENST00000538887+6102_248213270.0Coiled coilOntology_term=ECO:0000250


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Fusion Gene Sequence for TPM4-RPL18A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93413_93413_1_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000300933_RPL18A_chr19_17972102_ENST00000222247_length(transcript)=1357nt_BP=791nt
AAGTCCCGAAAAGGGGCACTTTCCAGCAGCTGTGGCCAGCGGTGCCGACGTCAGGCCCTCCCCCAGCGGTGCTGACGTCGGCGGTCCGGC
CGGGTGACCTCATCGCCCCGACGGCAGCCGGCCCGGGGGGCGGGGAGAGGCGGGGGCGGCCCCCGCGCAGGCAAAGGCTTGGGGGGCCGG
GGCGCGGCTGTGCAGCTCTCGCCGGAGCCGAGCCCAGCCGAGCGTCCGCCGCTGCCCGTGCGCCTCTGCGCCTCCGCGCCATGGCCGGCC
TCAACTCCCTGGAGGCGGTGAAACGCAAGATCCAGGCCCTGCAGCAGCAGGCGGACGAGGCGGAAGACCGCGCGCAGGGCCTGCAGCGGG
AGCTGGACGGCGAGCGCGAGCGGCGCGAGAAAGCTGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGG
ACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCAGAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGA
TAGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAAGAGGCTGACC
GCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAAT
GTGGTGACCTGGAAGAAGAACTCAAGAATGTTACTAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGCTACGAGAGTACAAGGTAG
TGGGTCGCTGCCTGCCCACCCCCAAATGCCACACGCCGCCCCTCTACCGCATGCGAATCTTTGCGCCTAATCATGTCGTCGCCAAGTCCC
GCTTCTGGTACTTTGTATCTCAGTTAAAGAAGATGAAGAAGTCTTCAGGGGAGATTGTCTACTGTGGGCAGGTGTTTGAGAAGTCCCCCC
TGCGGGTGAAGAACTTCGGGATCTGGCTGCGCTATGACTCCCGGAGCGGCACCCACAACATGTACCGGGAATACCGGGACCTGACCACCG
CAGGCGCTGTCACCCAGTGCTACCGAGACATGGGTGCCCGGCACCGCGCCCGAGCCCACTCCATTCAGATCATGAAGGTGGAGGAGATCG
CGGCCAGCAAGTGCCGCCGGCCGGCTGTCAAGCAGTTCCACGACTCCAAGATCAAGTTCCCGCTGCCCCACCGGGTCCTGCGCCGTCAGC
ACAAGCCACGCTTCACCACCAAGAGGCCCAACACCTTCTTCTAGGTGCAGGGCCCTCGTCCGGGTGTGCCCCAAATAAACTCAGGAACGC

>93413_93413_1_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000300933_RPL18A_chr19_17972102_ENST00000222247_length(amino acids)=424AA_BP=1
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKVVGRCLPTPKC
HTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRD

--------------------------------------------------------------
>93413_93413_2_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000300933_RPL18A_chr19_17972102_ENST00000599898_length(transcript)=1239nt_BP=791nt
AAGTCCCGAAAAGGGGCACTTTCCAGCAGCTGTGGCCAGCGGTGCCGACGTCAGGCCCTCCCCCAGCGGTGCTGACGTCGGCGGTCCGGC
CGGGTGACCTCATCGCCCCGACGGCAGCCGGCCCGGGGGGCGGGGAGAGGCGGGGGCGGCCCCCGCGCAGGCAAAGGCTTGGGGGGCCGG
GGCGCGGCTGTGCAGCTCTCGCCGGAGCCGAGCCCAGCCGAGCGTCCGCCGCTGCCCGTGCGCCTCTGCGCCTCCGCGCCATGGCCGGCC
TCAACTCCCTGGAGGCGGTGAAACGCAAGATCCAGGCCCTGCAGCAGCAGGCGGACGAGGCGGAAGACCGCGCGCAGGGCCTGCAGCGGG
AGCTGGACGGCGAGCGCGAGCGGCGCGAGAAAGCTGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGG
ACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCAGAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGA
TAGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAAGAGGCTGACC
GCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAAT
GTGGTGACCTGGAAGAAGAACTCAAGAATGTTACTAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGCTACGAGAGTACAAGTTAA
AGAAGATGAAGAAGTCTTCAGGGGAGATTGTCTACTGTGGGCAGGTGTTTGAGAAGTCCCCCCTGCGGGTGAAGAACTTCGGGATCTGGC
TGCGCTATGACTCCCGGAGCGGCACCCACAACATGTACCGGGAATACCGGGACCTGACCACCGCAGGCGCTGTCACCCAGTGCTACCGAG
ACATGGGTGCCCGGCACCGCGCCCGAGCCCACTCCATTCAGATCATGAAGGTGGAGGAGATCGCGGCCAGCAAGTGCCGCCGGCCGGCTG
TCAAGCAGTTCCACGACTCCAAGATCAAGTTCCCGCTGCCCCACCGGGTCCTGCGCCGTCAGCACAAGCCACGCTTCACCACCAAGAGGC

>93413_93413_2_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000300933_RPL18A_chr19_17972102_ENST00000599898_length(amino acids)=385AA_BP=1
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKLKKMKKSSGEI
VYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIK

--------------------------------------------------------------
>93413_93413_3_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000300933_RPL18A_chr19_17972102_ENST00000600147_length(transcript)=2128nt_BP=791nt
AAGTCCCGAAAAGGGGCACTTTCCAGCAGCTGTGGCCAGCGGTGCCGACGTCAGGCCCTCCCCCAGCGGTGCTGACGTCGGCGGTCCGGC
CGGGTGACCTCATCGCCCCGACGGCAGCCGGCCCGGGGGGCGGGGAGAGGCGGGGGCGGCCCCCGCGCAGGCAAAGGCTTGGGGGGCCGG
GGCGCGGCTGTGCAGCTCTCGCCGGAGCCGAGCCCAGCCGAGCGTCCGCCGCTGCCCGTGCGCCTCTGCGCCTCCGCGCCATGGCCGGCC
TCAACTCCCTGGAGGCGGTGAAACGCAAGATCCAGGCCCTGCAGCAGCAGGCGGACGAGGCGGAAGACCGCGCGCAGGGCCTGCAGCGGG
AGCTGGACGGCGAGCGCGAGCGGCGCGAGAAAGCTGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGG
ACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCAGAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGA
TAGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAAGAGGCTGACC
GCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAAT
GTGGTGACCTGGAAGAAGAACTCAAGAATGTTACTAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGCTACGAGAGTACAAGGTAG
TGGGTCGCTGCCTGCCCACCCCCAAATGCCACACGCCGCCCCTCTACCGCATGCGAATCTTTGCGCCTAATCATGTCGTCGCCAAGTCCC
GCTTCTGGTACTTTGTATCTCAGTTAAAGAAGATGAAGAAGTCTTCAGGGGAGATTGTCTACTGTGGGCAGGTGTTTGAGAAGTCCCCCC
TGCGGGTGAAGAACTTCGGGATCTGGCTGCGCTATGACTCCCGGAGCGGCACCCACAACATGTACCGGGAATACCGGGACCTGACCACCG
CAGGCGCTGTCACCCAGTGCTACCGAGACATGGGTGCCCGGCACCGCGCCCGAGCCCACTCCATTCAGATCATGAAGGTGGAGGAGATCG
CGGCCAGCAAGTGCCGCCGGCCGCACAAGCCACGCTTCACCACCAAGAGGCCCAACACCTTCTTCTAGGTGCAGGGCCCTCGTCCGGGTG
TGCCCCAAATAAACTCAGGAACGCCCCGGTGCTCGCCGCATGTTTTCTTTGCACACTGCAGAGCTCAAAGGGGTGCTATGAGAGGCCGGC
CCAGTCAGCTCCTGGGGTGCAGCTGAGCTGCCATTTCTTTGTCCTGGGAGGGGTCTTCAGTGCAAACAAACAAACCCTCACATCCTCCTG
TCCTGGAGTGGGCCCTCCAGGCGCCCCCACCCCTGAGCTCCCTCTTGCTTGGTCAGTTCTCAGCCCTGCTGGCAGCCCTGGGCTATGAGC
TGCAGGGGTACTGTCTGTCCTGGGCCCTAAATCTGTCCCAACTGCCTTGTGAGACACAGGCCTCCCAGGCTCCCCTGCTGAGTCTGGACC
AGGGAGAATCTCCCTAGATAGTGGGGTTGGCGTTCACTCCCTGGGGATTCTCCTAAGTCTCTGGTTCCCAAAGTTTTCAGAGTAGACACA
AGTGGGCACCCGAGGGGCGCTCTCTGCTGCTTGGGGGCTGTTTCCCTTTCACTGGTTGGGGGCCTCTTAGATGACGCCCTCATCTTGCCC
AAGGAGGTCAAGGACTCACCACAGGTACTCATCTCTGGGAAACTGCCTCAGGCCTGGAAAATTCCAGGCATGACACTAATCCCACCCTGG
CTGAGTCCTTCTGTCAGGTGGAGGCTAAGCTGGCATTGGAGAAGTTTGAGACACAGCCAAGAGCTCAGGCTCTGGGAGCCTCCCATCCTT
TGTTGCGTGACCTTGGGCAGCCCTGTTCTGGGCCAGCGGCCCTTCTGGGGCTTGCTGTCTTGATCTCAACATCGGGTTCCACATTGATGT

>93413_93413_3_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000300933_RPL18A_chr19_17972102_ENST00000600147_length(amino acids)=402AA_BP=1
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKVVGRCLPTPKC
HTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRD

--------------------------------------------------------------
>93413_93413_4_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000344824_RPL18A_chr19_17972102_ENST00000222247_length(transcript)=1323nt_BP=757nt
ATAAGGCCCTCTCCTCCACCCTGCCAGGCTCACTCTGCCCCACAGCCACAGCCCCTGACTGCCGCAGCCCCCACAGAGCCCGCCGCGCAC
CCCACGTCCCCCACGCCAGCGCCCAGCCATGGAGGCCATCAAGAAGAAAATGCAGATGCTGAAGTTGGACAAGGAGAATGCCATCGACCG
CGCGGAGCAGGCGGAGGCGGATAAGAAAGCCGCTGAGGACAAGTGCAAGCAGGTGGAGGAGGAGCTGACGCACCTCCAGAAGAAACTAAA
AGGGACAGAGGACGAGCTGGATAAATATTCCGAGGACCTGAAGGACGCGCAGGAGAAGCTGGAGCTCACGGAGAAGAAGGCCTCCGACGC
TGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCA
GAAGCTGGAGGAGGCAGAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGAAGAT
GGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCAT
CCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAGAATGTTAC
TAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGCTACGAGAGTACAAGGTAGTGGGTCGCTGCCTGCCCACCCCCAAATGCCACAC
GCCGCCCCTCTACCGCATGCGAATCTTTGCGCCTAATCATGTCGTCGCCAAGTCCCGCTTCTGGTACTTTGTATCTCAGTTAAAGAAGAT
GAAGAAGTCTTCAGGGGAGATTGTCTACTGTGGGCAGGTGTTTGAGAAGTCCCCCCTGCGGGTGAAGAACTTCGGGATCTGGCTGCGCTA
TGACTCCCGGAGCGGCACCCACAACATGTACCGGGAATACCGGGACCTGACCACCGCAGGCGCTGTCACCCAGTGCTACCGAGACATGGG
TGCCCGGCACCGCGCCCGAGCCCACTCCATTCAGATCATGAAGGTGGAGGAGATCGCGGCCAGCAAGTGCCGCCGGCCGGCTGTCAAGCA
GTTCCACGACTCCAAGATCAAGTTCCCGCTGCCCCACCGGGTCCTGCGCCGTCAGCACAAGCCACGCTTCACCACCAAGAGGCCCAACAC

>93413_93413_4_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000344824_RPL18A_chr19_17972102_ENST00000222247_length(amino acids)=403AA_BP=1
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSR
FWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIA

--------------------------------------------------------------
>93413_93413_5_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000344824_RPL18A_chr19_17972102_ENST00000599898_length(transcript)=1205nt_BP=757nt
ATAAGGCCCTCTCCTCCACCCTGCCAGGCTCACTCTGCCCCACAGCCACAGCCCCTGACTGCCGCAGCCCCCACAGAGCCCGCCGCGCAC
CCCACGTCCCCCACGCCAGCGCCCAGCCATGGAGGCCATCAAGAAGAAAATGCAGATGCTGAAGTTGGACAAGGAGAATGCCATCGACCG
CGCGGAGCAGGCGGAGGCGGATAAGAAAGCCGCTGAGGACAAGTGCAAGCAGGTGGAGGAGGAGCTGACGCACCTCCAGAAGAAACTAAA
AGGGACAGAGGACGAGCTGGATAAATATTCCGAGGACCTGAAGGACGCGCAGGAGAAGCTGGAGCTCACGGAGAAGAAGGCCTCCGACGC
TGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCA
GAAGCTGGAGGAGGCAGAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGAAGAT
GGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCAT
CCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAGAATGTTAC
TAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGCTACGAGAGTACAAGTTAAAGAAGATGAAGAAGTCTTCAGGGGAGATTGTCTA
CTGTGGGCAGGTGTTTGAGAAGTCCCCCCTGCGGGTGAAGAACTTCGGGATCTGGCTGCGCTATGACTCCCGGAGCGGCACCCACAACAT
GTACCGGGAATACCGGGACCTGACCACCGCAGGCGCTGTCACCCAGTGCTACCGAGACATGGGTGCCCGGCACCGCGCCCGAGCCCACTC
CATTCAGATCATGAAGGTGGAGGAGATCGCGGCCAGCAAGTGCCGCCGGCCGGCTGTCAAGCAGTTCCACGACTCCAAGATCAAGTTCCC
GCTGCCCCACCGGGTCCTGCGCCGTCAGCACAAGCCACGCTTCACCACCAAGAGGCCCAACACCTTCTTCTAGGTGCAGGGCCCTCGTCC

>93413_93413_5_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000344824_RPL18A_chr19_17972102_ENST00000599898_length(amino acids)=364AA_BP=1
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWL
RYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRP

--------------------------------------------------------------
>93413_93413_6_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000344824_RPL18A_chr19_17972102_ENST00000600147_length(transcript)=2094nt_BP=757nt
ATAAGGCCCTCTCCTCCACCCTGCCAGGCTCACTCTGCCCCACAGCCACAGCCCCTGACTGCCGCAGCCCCCACAGAGCCCGCCGCGCAC
CCCACGTCCCCCACGCCAGCGCCCAGCCATGGAGGCCATCAAGAAGAAAATGCAGATGCTGAAGTTGGACAAGGAGAATGCCATCGACCG
CGCGGAGCAGGCGGAGGCGGATAAGAAAGCCGCTGAGGACAAGTGCAAGCAGGTGGAGGAGGAGCTGACGCACCTCCAGAAGAAACTAAA
AGGGACAGAGGACGAGCTGGATAAATATTCCGAGGACCTGAAGGACGCGCAGGAGAAGCTGGAGCTCACGGAGAAGAAGGCCTCCGACGC
TGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCA
GAAGCTGGAGGAGGCAGAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGAAGAT
GGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCAT
CCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAGAATGTTAC
TAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGCTACGAGAGTACAAGGTAGTGGGTCGCTGCCTGCCCACCCCCAAATGCCACAC
GCCGCCCCTCTACCGCATGCGAATCTTTGCGCCTAATCATGTCGTCGCCAAGTCCCGCTTCTGGTACTTTGTATCTCAGTTAAAGAAGAT
GAAGAAGTCTTCAGGGGAGATTGTCTACTGTGGGCAGGTGTTTGAGAAGTCCCCCCTGCGGGTGAAGAACTTCGGGATCTGGCTGCGCTA
TGACTCCCGGAGCGGCACCCACAACATGTACCGGGAATACCGGGACCTGACCACCGCAGGCGCTGTCACCCAGTGCTACCGAGACATGGG
TGCCCGGCACCGCGCCCGAGCCCACTCCATTCAGATCATGAAGGTGGAGGAGATCGCGGCCAGCAAGTGCCGCCGGCCGCACAAGCCACG
CTTCACCACCAAGAGGCCCAACACCTTCTTCTAGGTGCAGGGCCCTCGTCCGGGTGTGCCCCAAATAAACTCAGGAACGCCCCGGTGCTC
GCCGCATGTTTTCTTTGCACACTGCAGAGCTCAAAGGGGTGCTATGAGAGGCCGGCCCAGTCAGCTCCTGGGGTGCAGCTGAGCTGCCAT
TTCTTTGTCCTGGGAGGGGTCTTCAGTGCAAACAAACAAACCCTCACATCCTCCTGTCCTGGAGTGGGCCCTCCAGGCGCCCCCACCCCT
GAGCTCCCTCTTGCTTGGTCAGTTCTCAGCCCTGCTGGCAGCCCTGGGCTATGAGCTGCAGGGGTACTGTCTGTCCTGGGCCCTAAATCT
GTCCCAACTGCCTTGTGAGACACAGGCCTCCCAGGCTCCCCTGCTGAGTCTGGACCAGGGAGAATCTCCCTAGATAGTGGGGTTGGCGTT
CACTCCCTGGGGATTCTCCTAAGTCTCTGGTTCCCAAAGTTTTCAGAGTAGACACAAGTGGGCACCCGAGGGGCGCTCTCTGCTGCTTGG
GGGCTGTTTCCCTTTCACTGGTTGGGGGCCTCTTAGATGACGCCCTCATCTTGCCCAAGGAGGTCAAGGACTCACCACAGGTACTCATCT
CTGGGAAACTGCCTCAGGCCTGGAAAATTCCAGGCATGACACTAATCCCACCCTGGCTGAGTCCTTCTGTCAGGTGGAGGCTAAGCTGGC
ATTGGAGAAGTTTGAGACACAGCCAAGAGCTCAGGCTCTGGGAGCCTCCCATCCTTTGTTGCGTGACCTTGGGCAGCCCTGTTCTGGGCC
AGCGGCCCTTCTGGGGCTTGCTGTCTTGATCTCAACATCGGGTTCCACATTGATGTGGGAAGTGACGCTGTGCAGGTGCTGGGGTCAGCC

>93413_93413_6_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000344824_RPL18A_chr19_17972102_ENST00000600147_length(amino acids)=381AA_BP=1
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSR
FWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIA

--------------------------------------------------------------
>93413_93413_7_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000538887_RPL18A_chr19_17972102_ENST00000222247_length(transcript)=1292nt_BP=726nt
ACTCTGCCCCACAGCCACAGCCCCTGACTGCCGCAGCCCCCACAGAGCCCGCCGCGCACCCCACGTCCCCCACGCCAGCGCCCAGCCATG
GAGGCCATCAAGAAGAAAATGCAGATGCTGAAGTTGGACAAGGAGAATGCCATCGACCGCGCGGAGCAGGCGGAGGCGGATAAGAAAGCC
GCTGAGGACAAGTGCAAGCAGGTGGAGGAGGAGCTGACGCACCTCCAGAAGAAACTAAAAGGGACAGAGGACGAGCTGGATAAATATTCC
GAGGACCTGAAGGACGCGCAGGAGAAGCTGGAGCTCACGGAGAAGAAGGCCTCCGACGCTGAAGGTGATGTGGCCGCCCTCAACCGACGC
ATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCAGAAAAAGCTGCAGAT
GAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCC
AAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAG
CGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAGAATGTTACTAACAATCTGAAATCTCTGGAGGCTGCATCT
GAAAAGCTACGAGAGTACAAGGTAGTGGGTCGCTGCCTGCCCACCCCCAAATGCCACACGCCGCCCCTCTACCGCATGCGAATCTTTGCG
CCTAATCATGTCGTCGCCAAGTCCCGCTTCTGGTACTTTGTATCTCAGTTAAAGAAGATGAAGAAGTCTTCAGGGGAGATTGTCTACTGT
GGGCAGGTGTTTGAGAAGTCCCCCCTGCGGGTGAAGAACTTCGGGATCTGGCTGCGCTATGACTCCCGGAGCGGCACCCACAACATGTAC
CGGGAATACCGGGACCTGACCACCGCAGGCGCTGTCACCCAGTGCTACCGAGACATGGGTGCCCGGCACCGCGCCCGAGCCCACTCCATT
CAGATCATGAAGGTGGAGGAGATCGCGGCCAGCAAGTGCCGCCGGCCGGCTGTCAAGCAGTTCCACGACTCCAAGATCAAGTTCCCGCTG
CCCCACCGGGTCCTGCGCCGTCAGCACAAGCCACGCTTCACCACCAAGAGGCCCAACACCTTCTTCTAGGTGCAGGGCCCTCGTCCGGGT

>93413_93413_7_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000538887_RPL18A_chr19_17972102_ENST00000222247_length(amino acids)=403AA_BP=1
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSR
FWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIA

--------------------------------------------------------------
>93413_93413_8_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000538887_RPL18A_chr19_17972102_ENST00000599898_length(transcript)=1174nt_BP=726nt
ACTCTGCCCCACAGCCACAGCCCCTGACTGCCGCAGCCCCCACAGAGCCCGCCGCGCACCCCACGTCCCCCACGCCAGCGCCCAGCCATG
GAGGCCATCAAGAAGAAAATGCAGATGCTGAAGTTGGACAAGGAGAATGCCATCGACCGCGCGGAGCAGGCGGAGGCGGATAAGAAAGCC
GCTGAGGACAAGTGCAAGCAGGTGGAGGAGGAGCTGACGCACCTCCAGAAGAAACTAAAAGGGACAGAGGACGAGCTGGATAAATATTCC
GAGGACCTGAAGGACGCGCAGGAGAAGCTGGAGCTCACGGAGAAGAAGGCCTCCGACGCTGAAGGTGATGTGGCCGCCCTCAACCGACGC
ATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCAGAAAAAGCTGCAGAT
GAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCC
AAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAG
CGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAGAATGTTACTAACAATCTGAAATCTCTGGAGGCTGCATCT
GAAAAGCTACGAGAGTACAAGTTAAAGAAGATGAAGAAGTCTTCAGGGGAGATTGTCTACTGTGGGCAGGTGTTTGAGAAGTCCCCCCTG
CGGGTGAAGAACTTCGGGATCTGGCTGCGCTATGACTCCCGGAGCGGCACCCACAACATGTACCGGGAATACCGGGACCTGACCACCGCA
GGCGCTGTCACCCAGTGCTACCGAGACATGGGTGCCCGGCACCGCGCCCGAGCCCACTCCATTCAGATCATGAAGGTGGAGGAGATCGCG
GCCAGCAAGTGCCGCCGGCCGGCTGTCAAGCAGTTCCACGACTCCAAGATCAAGTTCCCGCTGCCCCACCGGGTCCTGCGCCGTCAGCAC
AAGCCACGCTTCACCACCAAGAGGCCCAACACCTTCTTCTAGGTGCAGGGCCCTCGTCCGGGTGTGCCCCAAATAAACTCAGGAACGCCC

>93413_93413_8_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000538887_RPL18A_chr19_17972102_ENST00000599898_length(amino acids)=364AA_BP=1
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWL
RYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRP

--------------------------------------------------------------
>93413_93413_9_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000538887_RPL18A_chr19_17972102_ENST00000600147_length(transcript)=2063nt_BP=726nt
ACTCTGCCCCACAGCCACAGCCCCTGACTGCCGCAGCCCCCACAGAGCCCGCCGCGCACCCCACGTCCCCCACGCCAGCGCCCAGCCATG
GAGGCCATCAAGAAGAAAATGCAGATGCTGAAGTTGGACAAGGAGAATGCCATCGACCGCGCGGAGCAGGCGGAGGCGGATAAGAAAGCC
GCTGAGGACAAGTGCAAGCAGGTGGAGGAGGAGCTGACGCACCTCCAGAAGAAACTAAAAGGGACAGAGGACGAGCTGGATAAATATTCC
GAGGACCTGAAGGACGCGCAGGAGAAGCTGGAGCTCACGGAGAAGAAGGCCTCCGACGCTGAAGGTGATGTGGCCGCCCTCAACCGACGC
ATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCAGAAAAAGCTGCAGAT
GAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCC
AAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAG
CGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAGAATGTTACTAACAATCTGAAATCTCTGGAGGCTGCATCT
GAAAAGCTACGAGAGTACAAGGTAGTGGGTCGCTGCCTGCCCACCCCCAAATGCCACACGCCGCCCCTCTACCGCATGCGAATCTTTGCG
CCTAATCATGTCGTCGCCAAGTCCCGCTTCTGGTACTTTGTATCTCAGTTAAAGAAGATGAAGAAGTCTTCAGGGGAGATTGTCTACTGT
GGGCAGGTGTTTGAGAAGTCCCCCCTGCGGGTGAAGAACTTCGGGATCTGGCTGCGCTATGACTCCCGGAGCGGCACCCACAACATGTAC
CGGGAATACCGGGACCTGACCACCGCAGGCGCTGTCACCCAGTGCTACCGAGACATGGGTGCCCGGCACCGCGCCCGAGCCCACTCCATT
CAGATCATGAAGGTGGAGGAGATCGCGGCCAGCAAGTGCCGCCGGCCGCACAAGCCACGCTTCACCACCAAGAGGCCCAACACCTTCTTC
TAGGTGCAGGGCCCTCGTCCGGGTGTGCCCCAAATAAACTCAGGAACGCCCCGGTGCTCGCCGCATGTTTTCTTTGCACACTGCAGAGCT
CAAAGGGGTGCTATGAGAGGCCGGCCCAGTCAGCTCCTGGGGTGCAGCTGAGCTGCCATTTCTTTGTCCTGGGAGGGGTCTTCAGTGCAA
ACAAACAAACCCTCACATCCTCCTGTCCTGGAGTGGGCCCTCCAGGCGCCCCCACCCCTGAGCTCCCTCTTGCTTGGTCAGTTCTCAGCC
CTGCTGGCAGCCCTGGGCTATGAGCTGCAGGGGTACTGTCTGTCCTGGGCCCTAAATCTGTCCCAACTGCCTTGTGAGACACAGGCCTCC
CAGGCTCCCCTGCTGAGTCTGGACCAGGGAGAATCTCCCTAGATAGTGGGGTTGGCGTTCACTCCCTGGGGATTCTCCTAAGTCTCTGGT
TCCCAAAGTTTTCAGAGTAGACACAAGTGGGCACCCGAGGGGCGCTCTCTGCTGCTTGGGGGCTGTTTCCCTTTCACTGGTTGGGGGCCT
CTTAGATGACGCCCTCATCTTGCCCAAGGAGGTCAAGGACTCACCACAGGTACTCATCTCTGGGAAACTGCCTCAGGCCTGGAAAATTCC
AGGCATGACACTAATCCCACCCTGGCTGAGTCCTTCTGTCAGGTGGAGGCTAAGCTGGCATTGGAGAAGTTTGAGACACAGCCAAGAGCT
CAGGCTCTGGGAGCCTCCCATCCTTTGTTGCGTGACCTTGGGCAGCCCTGTTCTGGGCCAGCGGCCCTTCTGGGGCTTGCTGTCTTGATC

>93413_93413_9_TPM4-RPL18A_TPM4_chr19_16199930_ENST00000538887_RPL18A_chr19_17972102_ENST00000600147_length(amino acids)=381AA_BP=1
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSR
FWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TPM4-RPL18A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TPM4-RPL18A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TPM4-RPL18A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource