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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TPR-MET (FusionGDB2 ID:93449)

Fusion Gene Summary for TPR-MET

check button Fusion gene summary
Fusion gene informationFusion gene name: TPR-MET
Fusion gene ID: 93449
HgeneTgene
Gene symbol

TPR

MET

Gene ID

7175

8731

Gene nametranslocated promoter region, nuclear basket proteinRNA guanine-7 methyltransferase
Synonyms-CMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMet
Cytomap

1q31.1

18p11.21

Type of geneprotein-codingprotein-coding
Descriptionnucleoprotein TPRNPC-associated intranuclear proteinmegatornuclear pore complex-associated protein TPRtranslocated promoter region (to activated MET oncogene)translocated promoter region proteintumor potentiating regionmRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase
Modification date2020031320200329
UniProtAcc

TRANK1

Q9H1A3

Ensembl transtripts involved in fusion geneENST00000367478, ENST00000474852, 
ENST00000436117, ENST00000495962, 
ENST00000539704, ENST00000318493, 
ENST00000397752, 
Fusion gene scores* DoF score8 X 11 X 4=35214 X 18 X 10=2520
# samples 827
** MAII scorelog2(8/352*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2520*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TPR [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTPR(186337018)-MET(116414931), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTPR

GO:0006404

RNA import into nucleus

9864356

HgeneTPR

GO:0006606

protein import into nucleus

9864356

HgeneTPR

GO:0031990

mRNA export from nucleus in response to heat stress

17897941

HgeneTPR

GO:0034605

cellular response to heat

17897941

HgeneTPR

GO:0046832

negative regulation of RNA export from nucleus

22253824

HgeneTPR

GO:0070849

response to epidermal growth factor

18794356

TgeneMET

GO:0006370

7-methylguanosine mRNA capping

27422871


check buttonFusion gene breakpoints across TPR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AU08818TPRchr1

186337018

-METchr7

116414931

+
ChiTaRS5.0N/AU19348TPRchr1

186337018

-METchr7

116414931

+


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Fusion Gene ORF analysis for TPR-MET

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000367478ENST00000436117TPRchr1

186337018

-METchr7

116414931

+
5CDS-intronENST00000367478ENST00000495962TPRchr1

186337018

-METchr7

116414931

+
5CDS-intronENST00000367478ENST00000539704TPRchr1

186337018

-METchr7

116414931

+
5UTR-3CDSENST00000474852ENST00000318493TPRchr1

186337018

-METchr7

116414931

+
5UTR-3CDSENST00000474852ENST00000397752TPRchr1

186337018

-METchr7

116414931

+
5UTR-intronENST00000474852ENST00000436117TPRchr1

186337018

-METchr7

116414931

+
5UTR-intronENST00000474852ENST00000495962TPRchr1

186337018

-METchr7

116414931

+
5UTR-intronENST00000474852ENST00000539704TPRchr1

186337018

-METchr7

116414931

+
In-frameENST00000367478ENST00000318493TPRchr1

186337018

-METchr7

116414931

+
In-frameENST00000367478ENST00000397752TPRchr1

186337018

-METchr7

116414931

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367478TPRchr1186337018-ENST00000397752METchr7116414931+41317242971868523
ENST00000367478TPRchr1186337018-ENST00000318493METchr7116414931+20877242971868523

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367478ENST00000397752TPRchr1186337018-METchr7116414931+0.0002095720.9997905
ENST00000367478ENST00000318493TPRchr1186337018-METchr7116414931+0.0008613460.9991386

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Fusion Genomic Features for TPR-MET


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TPRchr1186337017-METchr7116414934+0.0003849330.9996151
TPRchr1186337017-METchr7116414934+0.0003849330.9996151

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TPR-MET


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:186337018/chr7:116414931)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPR

TRANK1

MET

Q9H1A3

2925

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMETchr1:186337018chr7:116414931ENST0000031849313211078_134510271409.0DomainProtein kinase
TgeneMETchr1:186337018chr7:116414931ENST0000039775213211078_134510091391.0DomainProtein kinase
TgeneMETchr1:186337018chr7:116414931ENST00000436117091078_13450765.0DomainProtein kinase
TgeneMETchr1:186337018chr7:116414931ENST000004361170927_5150765.0DomainSema
TgeneMETchr1:186337018chr7:116414931ENST0000043611709563_6550765.0DomainNote=IPT/TIG 1
TgeneMETchr1:186337018chr7:116414931ENST0000043611709657_7390765.0DomainNote=IPT/TIG 2
TgeneMETchr1:186337018chr7:116414931ENST0000043611709742_8360765.0DomainNote=IPT/TIG 3
TgeneMETchr1:186337018chr7:116414931ENST0000031849313211084_109210271409.0Nucleotide bindingATP
TgeneMETchr1:186337018chr7:116414931ENST0000039775213211084_109210091391.0Nucleotide bindingATP
TgeneMETchr1:186337018chr7:116414931ENST00000436117091084_10920765.0Nucleotide bindingATP
TgeneMETchr1:186337018chr7:116414931ENST000004361170925_9320765.0Topological domainExtracellular
TgeneMETchr1:186337018chr7:116414931ENST0000043611709956_13900765.0Topological domainCytoplasmic
TgeneMETchr1:186337018chr7:116414931ENST0000043611709933_9550765.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTPRchr1:186337018chr7:116414931ENST00000367478-4511215_16301422364.0Coiled coilOntology_term=ECO:0000255
HgeneTPRchr1:186337018chr7:116414931ENST00000367478-45129_3701422364.0Coiled coilOntology_term=ECO:0000255
HgeneTPRchr1:186337018chr7:116414931ENST00000367478-451423_6021422364.0Coiled coilOntology_term=ECO:0000255
HgeneTPRchr1:186337018chr7:116414931ENST00000367478-451661_11731422364.0Coiled coilOntology_term=ECO:0000255
HgeneTPRchr1:186337018chr7:116414931ENST00000367478-4511833_18361422364.0Compositional biasNote=Poly-Glu
HgeneTPRchr1:186337018chr7:116414931ENST00000367478-4511971_19781422364.0Compositional biasNote=Poly-Asp
HgeneTPRchr1:186337018chr7:116414931ENST00000367478-4512309_23121422364.0Compositional biasNote=Poly-Ser
HgeneTPRchr1:186337018chr7:116414931ENST00000367478-451527_5301422364.0Compositional biasNote=Poly-Ser
HgeneTPRchr1:186337018chr7:116414931ENST00000367478-4511812_18671422364.0RegionNote=Sufficient and essential for mediating its nuclear import
HgeneTPRchr1:186337018chr7:116414931ENST00000367478-451437_5131422364.0RegionNote=Necessary for association to the NPC
TgeneMETchr1:186337018chr7:116414931ENST00000318493132127_51510271409.0DomainSema
TgeneMETchr1:186337018chr7:116414931ENST000003184931321563_65510271409.0DomainNote=IPT/TIG 1
TgeneMETchr1:186337018chr7:116414931ENST000003184931321657_73910271409.0DomainNote=IPT/TIG 2
TgeneMETchr1:186337018chr7:116414931ENST000003184931321742_83610271409.0DomainNote=IPT/TIG 3
TgeneMETchr1:186337018chr7:116414931ENST00000397752132127_51510091391.0DomainSema
TgeneMETchr1:186337018chr7:116414931ENST000003977521321563_65510091391.0DomainNote=IPT/TIG 1
TgeneMETchr1:186337018chr7:116414931ENST000003977521321657_73910091391.0DomainNote=IPT/TIG 2
TgeneMETchr1:186337018chr7:116414931ENST000003977521321742_83610091391.0DomainNote=IPT/TIG 3
TgeneMETchr1:186337018chr7:116414931ENST00000318493132125_93210271409.0Topological domainExtracellular
TgeneMETchr1:186337018chr7:116414931ENST000003184931321956_139010271409.0Topological domainCytoplasmic
TgeneMETchr1:186337018chr7:116414931ENST00000397752132125_93210091391.0Topological domainExtracellular
TgeneMETchr1:186337018chr7:116414931ENST000003977521321956_139010091391.0Topological domainCytoplasmic
TgeneMETchr1:186337018chr7:116414931ENST000003184931321933_95510271409.0TransmembraneHelical
TgeneMETchr1:186337018chr7:116414931ENST000003977521321933_95510091391.0TransmembraneHelical


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Fusion Gene Sequence for TPR-MET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93449_93449_1_TPR-MET_TPR_chr1_186337018_ENST00000367478_MET_chr7_116414931_ENST00000318493_length(transcript)=2087nt_BP=724nt
GCGCAAGAGGATCAGGGATAGCCTCTGAGCTCGGGTTCCCAGGGTTCGTAGCTTCCAACGGCTGCGCGCGCACTTCGGTCGCGGGCGGTG
AGGTGCTGTTGCTGAAACGCTGCCGCTGAGGGTGGACTCGATTTCCCAGGGTCCCGCCGCGGGAGTCTCCGGCGGGCGGGCGCGCGCGAG
CCACCGAGCGAGGTGATAGAGGCGGCGGCCCAGGCGTCTGGGTCCTGCTGGTCTTCGCCTTTCTTCTCCGCTTCTACCCCGTCGGCCGCT
GCCACTGGGGTCCCTGGCCCCACCGACATGGCGGCGGTGTTGCAGCAAGTCCTGGAGCGCACGGAGCTGAACAAGCTGCCCAAGTCTGTC
CAGAACAAACTTGAAAAGTTCCTTGCTGATCAGCAATCCGAGATCGATGGCCTGAAGGGGCGGCATGAGAAATTTAAGGTGGAGAGCGAA
CAACAGTATTTTGAAATAGAAAAGAGGTTGTCCCACAGTCAGGAGAGACTTGTGAATGAAACCCGAGAGTGTCAAAGCTTGCGGCTTGAG
CTAGAGAAACTCAACAATCAACTGAAGGCACTAACTGAGAAAAACAAAGAACTTGAAATTGCTCAGGATCGCAATATTGCCATTCAGAGC
CAATTTACAAGAACAAAGGAAGAATTAGAAGCTGAGAAAAGAGACTTAATTAGAACCAATGAGAGACTATCTCAAGAACTTGAATACTTA
ACAGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGG
GACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCAT
GTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTG
GACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGA
ATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCA
TACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTA
GCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTC
AAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAG
TGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACA
AGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGC
CCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCA
GCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTG
TTGTCATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCA
ACAGTCCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTAT
AGGACTTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCAC

>93449_93449_1_TPR-MET_TPR_chr1_186337018_ENST00000367478_MET_chr7_116414931_ENST00000318493_length(amino acids)=523AA_BP=140
MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLK
ALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLL
QNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP
NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLAR
DMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVML

--------------------------------------------------------------
>93449_93449_2_TPR-MET_TPR_chr1_186337018_ENST00000367478_MET_chr7_116414931_ENST00000397752_length(transcript)=4131nt_BP=724nt
GCGCAAGAGGATCAGGGATAGCCTCTGAGCTCGGGTTCCCAGGGTTCGTAGCTTCCAACGGCTGCGCGCGCACTTCGGTCGCGGGCGGTG
AGGTGCTGTTGCTGAAACGCTGCCGCTGAGGGTGGACTCGATTTCCCAGGGTCCCGCCGCGGGAGTCTCCGGCGGGCGGGCGCGCGCGAG
CCACCGAGCGAGGTGATAGAGGCGGCGGCCCAGGCGTCTGGGTCCTGCTGGTCTTCGCCTTTCTTCTCCGCTTCTACCCCGTCGGCCGCT
GCCACTGGGGTCCCTGGCCCCACCGACATGGCGGCGGTGTTGCAGCAAGTCCTGGAGCGCACGGAGCTGAACAAGCTGCCCAAGTCTGTC
CAGAACAAACTTGAAAAGTTCCTTGCTGATCAGCAATCCGAGATCGATGGCCTGAAGGGGCGGCATGAGAAATTTAAGGTGGAGAGCGAA
CAACAGTATTTTGAAATAGAAAAGAGGTTGTCCCACAGTCAGGAGAGACTTGTGAATGAAACCCGAGAGTGTCAAAGCTTGCGGCTTGAG
CTAGAGAAACTCAACAATCAACTGAAGGCACTAACTGAGAAAAACAAAGAACTTGAAATTGCTCAGGATCGCAATATTGCCATTCAGAGC
CAATTTACAAGAACAAAGGAAGAATTAGAAGCTGAGAAAAGAGACTTAATTAGAACCAATGAGAGACTATCTCAAGAACTTGAATACTTA
ACAGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGG
GACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCAT
GTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTG
GACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGA
ATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCA
TACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTA
GCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTC
AAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAG
TGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACA
AGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGC
CCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCA
GCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTG
TTGTCATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCA
ACAGTCCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTAT
AGGACTTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCAC
GGACCAATGGCCTGCAGCCGTGACAACACTCCTGTCATATTGGAGTCCAAAACTTGAATTCTGGGTTGAATTTTTTAAAAATCAGGTACC
ACTTGATTTCATATGGGAAATTGAAGCAGGAAATATTGAGGGCTTCTTGATCACAGAAAACTCAGAAGAGATAGTAATGCTCAGGACAGG
AGCGGCAGCCCCAGAACAGGCCACTCATTTAGAATTCTAGTGTTTCAAAACACTTTTGTGTGTTGTATGGTCAATAACATTTTTCATTAC
TGATGGTGTCATTCACCCATTAGGTAAACATTCCCTTTTAAATGTTTGTTTGTTTTTTGAGACAGGATCTCACTCTGTTGCCAGGGCTGT
AGTGCAGTGGTGTGATCATAGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCCTCCCGAATAGCTGGGACTACAGGCGCACACCACCAT
CCCCGGCTAATTTTTGTATTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCAAGGCTGGTTTCAAACTCCTGGACTCAAGAAATCCACCC
ACCTCAGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACTGCGCCCAGCCCTTATAAATTTTTGTATAGACATTCCTTTGGTTGGAA
GAATATTTATAGGCAATACAGTCAAAGTTTCAAAATAGCATCACACAAAACATGTTTATAAATGAACAGGATGTAATGTACATAGATGAC
ATTAAGAAAATTTGTATGAAATAATTTAGTCATCATGAAATATTTAGTTGTCATATAAAAACCCACTGTTTGAGAATGATGCTACTCTGA
TCTAATGAATGTGAACATGTAGATGTTTTGTGTGTATTTTTTTAAATGAAAACTCAAAATAAGACAAGTAATTTGTTGATAAATATTTTT
AAAGATAACTCAGCATGTTTGTAAAGCAGGATACATTTTACTAAAAGGTTCATTGGTTCCAATCACAGCTCATAGGTAGAGCAAAGAAAG
GGTGGATGGATTGAAAAGATTAGCCTCTGTCTCGGTGGCAGGTTCCCACCTCGCAAGCAATTGGAAACAAAACTTTTGGGGAGTTTTATT
TTGCATTAGGGTGTGTTTTATGTTAAGCAAAACATACTTTAGAAACAAATGAAAAAGGCAATTGAAAATCCCAGCTATTTCACCTAGATG
GAATAGCCACCCTGAGCAGAACTTTGTGATGCTTCATTCTGTGGAATTTTGTGCTTGCTACTGTATAGTGCATGTGGTGTAGGTTACTCT
AACTGGTTTTGTCGACGTAAACATTTAAAGTGTTATATTTTTTATAAAAATGTTTATTTTTAATGATATGAGAAAAATTTTGTTAGGCCA
CAAAAACACTGCACTGTGAACATTTTAGAAAAGGTATGTCAGACTGGGATTAATGACAGCATGATTTTCAATGACTGTAAATTGCGATAA
GGAAATGTACTGATTGCCAATACACCCCACCCTCATTACATCATCAGGACTTGAAGCCAAGGGTTAACCCAGCAAGCTACAAAGAGGGTG
TGTCACACTGAAACTCAATAGTTGAGTTTGGCTGTTGTTGCAGGAAAATGATTATAACTAAAAGCTCTCTGATAGTGCAGAGACTTACCA
GAAGACACAAGGAATTGTACTGAAGAGCTATTACAATCCAAATATTGCCGTTTCATAAATGTAATAAGTAATACTAATTCACAGAGTATT
GTAAATGGTGGATGACAAAAGAAAATCTGCTCTGTGGAAAGAAAGAACTGTCTCTACCAGGGTCAAGAGCATGAACGCATCAATAGAAAG
AACTCGGGGAAACATCCCATCAACAGGACTACACACTTGTATATACATTCTTGAGAACACTGCAATGTGAAAATCACGTTTGCTATTTAT
AAACTTGTCCTTAGATTAATGTGTCTGGACAGATTGTGGGAGTAAGTGATTCTTCTAAGAATTAGATACTTGTCACTGCCTATACCTGCA

>93449_93449_2_TPR-MET_TPR_chr1_186337018_ENST00000367478_MET_chr7_116414931_ENST00000397752_length(amino acids)=523AA_BP=140
MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLK
ALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLL
QNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP
NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLAR
DMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVML

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Fusion Gene PPI Analysis for TPR-MET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMETchr1:186337018chr7:116414931ENST0000031849313211320_13591027.33333333333331409.0MUC20
TgeneMETchr1:186337018chr7:116414931ENST0000039775213211320_13591009.33333333333341391.0MUC20
TgeneMETchr1:186337018chr7:116414931ENST00000436117091320_13590.0765.0MUC20
TgeneMETchr1:186337018chr7:116414931ENST0000031849313211212_13901027.33333333333331409.0RANBP9
TgeneMETchr1:186337018chr7:116414931ENST0000039775213211212_13901009.33333333333341391.0RANBP9
TgeneMETchr1:186337018chr7:116414931ENST00000436117091212_13900.0765.0RANBP9


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TPR-MET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TPR-MET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource