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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TPST1-ANLN (FusionGDB2 ID:93461)

Fusion Gene Summary for TPST1-ANLN

check button Fusion gene summary
Fusion gene informationFusion gene name: TPST1-ANLN
Fusion gene ID: 93461
HgeneTgene
Gene symbol

TPST1

ANLN

Gene ID

8460

54443

Gene nametyrosylprotein sulfotransferase 1anillin actin binding protein
SynonymsTANGO13AFSGS8|Scraps|scra
Cytomap

7q11.21

7p14.2

Type of geneprotein-codingprotein-coding
Descriptionprotein-tyrosine sulfotransferase 1TPST-1transport and golgi organization 13 homolog Aanillin
Modification date2020031320200313
UniProtAcc.

Q9NQW6

Ensembl transtripts involved in fusion geneENST00000480281, ENST00000304842, 
ENST00000265748, ENST00000396068, 
ENST00000495714, 
Fusion gene scores* DoF score6 X 5 X 3=909 X 9 X 6=486
# samples 610
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/486*10)=-2.28095631383106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TPST1 [Title/Abstract] AND ANLN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTPST1(65751696)-ANLN(36435874), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTPST1

GO:0006478

peptidyl-tyrosine sulfation

9501187

TgeneANLN

GO:0000281

mitotic cytokinesis

10931866


check buttonFusion gene breakpoints across TPST1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANLN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1324TPST1chr7

65751696

+ANLNchr7

36435874

+


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Fusion Gene ORF analysis for TPST1-ANLN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000480281ENST00000265748TPST1chr7

65751696

+ANLNchr7

36435874

+
3UTR-3CDSENST00000480281ENST00000396068TPST1chr7

65751696

+ANLNchr7

36435874

+
3UTR-intronENST00000480281ENST00000495714TPST1chr7

65751696

+ANLNchr7

36435874

+
5CDS-intronENST00000304842ENST00000495714TPST1chr7

65751696

+ANLNchr7

36435874

+
In-frameENST00000304842ENST00000265748TPST1chr7

65751696

+ANLNchr7

36435874

+
In-frameENST00000304842ENST00000396068TPST1chr7

65751696

+ANLNchr7

36435874

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000304842TPST1chr765751696+ENST00000265748ANLNchr736435874+6017146942548251466
ENST00000304842TPST1chr765751696+ENST00000396068ANLNchr736435874+5906146942547141429

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000304842ENST00000265748TPST1chr765751696+ANLNchr736435874+0.0006619370.9993381
ENST00000304842ENST00000396068TPST1chr765751696+ANLNchr736435874+0.0005542640.99944574

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Fusion Genomic Features for TPST1-ANLN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TPST1chr765751696+ANLNchr736435874+9.81E-080.9999999
TPST1chr765751696+ANLNchr736435874+9.81E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TPST1-ANLN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:65751696/chr7:36435874)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANLN

Q9NQW6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTPST1chr7:65751696chr7:36435874ENST00000304842+36286_295348446.0RegionPAPS binding
HgeneTPST1chr7:65751696chr7:36435874ENST00000304842+3679_83348446.0RegionPAPS binding
HgeneTPST1chr7:65751696chr7:36435874ENST00000304842+361_8348446.0Topological domainCytoplasmic
HgeneTPST1chr7:65751696chr7:36435874ENST00000304842+369_25348446.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneANLNchr7:65751696chr7:36435874ENST00000265748024569_60461125.0Coiled coilOntology_term=ECO:0000255
TgeneANLNchr7:65751696chr7:36435874ENST00000396068023569_60461088.0Coiled coilOntology_term=ECO:0000255
TgeneANLNchr7:65751696chr7:36435874ENST00000265748024983_110761125.0DomainPH
TgeneANLNchr7:65751696chr7:36435874ENST00000396068023983_110761088.0DomainPH
TgeneANLNchr7:65751696chr7:36435874ENST00000265748024730_112461125.0RegionNote=Localization to the cleavage furrow
TgeneANLNchr7:65751696chr7:36435874ENST00000396068023730_112461088.0RegionNote=Localization to the cleavage furrow

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTPST1chr7:65751696chr7:36435874ENST00000304842+3626_370348446.0Topological domainLumenal
TgeneANLNchr7:65751696chr7:36435874ENST000002657480241_23061125.0RegionNote=Nuclear localization
TgeneANLNchr7:65751696chr7:36435874ENST000002657480241_4561125.0RegionNote=Required for ubiquitination
TgeneANLNchr7:65751696chr7:36435874ENST000003960680231_23061088.0RegionNote=Nuclear localization
TgeneANLNchr7:65751696chr7:36435874ENST000003960680231_4561088.0RegionNote=Required for ubiquitination


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Fusion Gene Sequence for TPST1-ANLN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93461_93461_1_TPST1-ANLN_TPST1_chr7_65751696_ENST00000304842_ANLN_chr7_36435874_ENST00000265748_length(transcript)=6017nt_BP=1469nt
TCCTTCGGTGGGCAGCCGGCCGGAACTCACGAATCAGAGCAGCCGACACATCGTCCGCTCAGCCAATCGTAGCAGATGTGTGATCCCGCC
ACCTCCCCGGACCCTGGCGGTTGTCGCTGAGTTGGCGACCGCGGGAGACGCTGCTGAGGCGGCTTCGGTTGCGGGTCGGAACGGCGCTGC
TCTGCGGGGCCGGTCCAGGCTGGCAGCTGCCGGCGCTTGGCGGTGAGGGCGGGCTCCCGAGTGGCCCCCCACCGAAGGCGGTGGGACCAG
CGGCTGAGGCCAGGATGCCGTCCAGGCGGCGCGGCGGCTCCTCACTCATCCCAGATGTTGGTTATCTTTCTGAAGTAGACTGTCCATGGC
CTGAACATTTTCCGAAAATCATTTTGAGCAAAATATCTGTTTAATAACAAGATAACCACATCAAGATGGTTGGAAAGCTGAAGCAGAACT
TACTATTGGCATGTCTGGTGATTAGTTCTGTGACTGTGTTTTACCTGGGCCAGCATGCCATGGAATGCCATCACCGGATAGAGGAACGTA
GCCAGCCAGTCAAATTGGAGAGCACAAGGACCACTGTGAGAACTGGCCTGGACCTCAAAGCCAACAAAACCTTTGCCTATCACAAAGATA
TGCCTTTAATATTTATTGGAGGTGTGCCTCGGAGTGGAACCACACTCATGAGGGCCATGCTGGACGCACATCCTGACATTCGCTGTGGAG
AGGAAACCAGGGTCATTCCCCGAATCCTGGCCCTGAAGCAGATGTGGTCACGGTCAAGTAAAGAGAAGATCCGCCTGGATGAGGCTGGTG
TTACTGATGAAGTGCTGGATTCTGCCATGCAAGCCTTCTTACTAGAAATTATCGTTAAGCATGGGGAGCCAGCCCCTTATTTATGTAATA
AAGATCCTTTTGCCCTGAAATCTTTAACTTACCTTTCTAGGTTATTCCCCAATGCCAAATTTCTCCTGATGGTCCGAGATGGCCGGGCAT
CAGTACATTCAATGATTTCTCGAAAAGTTACTATAGCTGGATTTGATCTGAACAGCTATAGGGACTGTTTGACAAAGTGGAATCGTGCTA
TAGAGACCATGTATAACCAGTGTATGGAGGTTGGTTATAAAAAGTGCATGTTGGTTCACTATGAACAACTTGTCTTACATCCTGAACGGT
GGATGAGAACACTCTTAAAGTTCCTCCAGATTCCATGGAACCACTCAGTATTGCACCATGAAGAGATGATTGGGAAAGCTGGGGGAGTGT
CTCTGTCAAAAGTGGAGAGATCTACAGACCAAGTAATCAAGCCAGTCAATGTAGGAGCTCTATCAAAATGGGTTGGGAAGATACCGCCAG
ATGTTTTACAAGACATGGCAGTGATTGCTCCTATGCTTGCCAAGCTTGGATATGACCCATATGCCAACCCACCTAACTACGGAAAACCTG
ATCCCAAAATTATTGAAAACACTCGAAGGAAACTGCTGGAGCGAACCCGTGCCAGGCGAGAGAATCTTCAGAGAAAAATGGCTGAGAGGC
CCACAGCAGCTCCAAGGTCTATGACTCATGCTAAGCGAGCTAGACAGCCACTTTCAGAAGCAAGTAACCAGCAGCCCCTCTCTGGTGGTG
AAGAGAAATCTTGTACAAAACCATCGCCATCAAAAAAACGCTGTTCTGACAACACTGAAGTAGAAGTTTCTAACTTGGAAAATAAACAAC
CAGTTGAGTCGACATCTGCAAAATCTTGTTCTCCAAGTCCTGTGTCTCCTCAGGTGCAGCCACAAGCAGCAGATACCATCAGTGATTCTG
TTGCTGTCCCGGCATCACTGCTGGGCATGAGGAGAGGGCTGAACTCAAGATTGGAAGCAACTGCAGCCTCCTCAGTTAAAACACGTATGC
AAAAACTTGCAGAGCAACGGCGCCGTTGGGATAATGATGATATGACAGATGACATTCCTGAAAGCTCACTCTTCTCACCAATGCCATCAG
AGGAAAAGGCTGCTTCCCCTCCCAGACCTCTGCTTTCAAATGCCTCGGCAACTCCAGTTGGCAGAAGGGGCCGTCTGGCCAATCTTGCTG
CAACTATTTGCTCCTGGGAAGATGATGTAAATCACTCATTTGCAAAACAAAACAGTGTACAAGAACAGCCTGGTACCGCTTGTTTATCCA
AATTTTCCTCTGCAAGTGGAGCATCTGCTAGGATCAATAGCAGCAGTGTTAAGCAGGAAGCTACATTCTGTTCCCAAAGGGATGGCGATG
CCTCTTTGAATAAAGCCCTATCCTCAAGTGCTGATGATGCGTCTTTGGTTAATGCCTCAATTTCCAGCTCTGTGAAAGCTACTTCTCCAG
TGAAATCTACTACATCTATCACTGATGCTAAAAGTTGTGAGGGACAAAATCCTGAGCTACTTCCAAAAACTCCTATTAGTCCTCTGAAAA
CGGGGGTATCGAAACCAATTGTGAAGTCAACTTTATCCCAGACAGTTCCATCCAAGGGAGAATTAAGTAGAGAAATTTGTCTGCAATCTC
AATCTAAAGACAAATCTACGACACCAGGAGGAACAGGAATTAAGCCTTTCCTGGAACGCTTTGGAGAGCGTTGTCAAGAACATAGCAAAG
AAAGTCCAGCTCGTAGCACACCCCACAGAACCCCCATTATTACTCCAAATACAAAGGCCATCCAAGAAAGATTATTCAAGCAAGACACAT
CTTCATCTACTACCCATTTAGCACAACAGCTCAAGCAGGAACGTCAAAAAGAACTAGCATGTCTTCGTGGCCGATTTGACAAGGGCAATA
TATGGAGTGCAGAAAAAGGCGGAAACTCAAAAAGCAAACAACTAGAAACCAAACAGGAAACTCACTGTCAGAGCACTCCCCTCAAAAAAC
ACCAAGGTGTTTCAAAAACTCAGTCACTTCCAGTAACAGAAAAGGTGACCGAAAACCAGATACCAGCCAAAAATTCTAGTACAGAACCTA
AAGGTTTCACTGAATGCGAAATGACGAAATCTAGCCCTTTGAAAATAACATTGTTTTTAGAAGAGGACAAATCCTTAAAAGTAACATCAG
ACCCAAAGGTTGAGCAGAAAATTGAAGTGATACGTGAAATTGAGATGAGTGTGGATGATGATGATATCAATAGTTCGAAAGTAATTAATG
ACCTCTTCAGTGATGTCCTAGAGGAAGGTGAACTAGATATGGAGAAGAGCCAAGAGGAGATGGATCAAGCATTAGCAGAAAGCAGCGAAG
AACAGGAAGATGCACTGAATATCTCCTCAATGTCTTTACTTGCACCATTGGCACAAACAGTTGGTGTGGTAAGTCCAGAGAGTTTAGTGT
CCACACCTAGACTGGAATTGAAAGACACCAGCAGAAGTGATGAAAGTCCAAAACCAGGAAAATTCCAAAGAACTCGTGTCCCTCGAGCTG
AATCTGGTGATAGCCTTGGTTCTGAAGATCGTGATCTTCTTTACAGCATTGATGCATATAGATCTCAAAGATTCAAAGAAACAGAACGTC
CATCAATAAAGCAGGTGATTGTTCGGAAGGAAGATGTTACTTCAAAACTGGATGAAAAAAATAATGCCTTTCCTTGTCAAGTTAATATCA
AACAGAAAATGCAGGAACTCAATAACGAAATAAATATGCAACAGACAGTGATCTATCAAGCTAGCCAGGCTCTTAACTGCTGTGTTGATG
AAGAACATGGAAAAGGGTCCCTAGAAGAAGCTGAAGCAGAAAGACTTCTTCTAATTGCAACTGGGAAGAGAACACTTTTGATTGATGAAT
TGAATAAATTGAAGAACGAAGGACCTCAGAGGAAGAATAAGGCTAGTCCCCAAAGTGAATTTATGCCATCCAAAGGATCAGTTACTTTGT
CAGAAATCCGCTTGCCTCTAAAAGCAGATTTTGTCTGCAGTACGGTTCAGAAACCAGATGCAGCAAATTACTATTACTTAATTATACTAA
AAGCAGGAGCTGAAAATATGGTAGCCACACCATTAGCAAGTACTTCAAACTCTCTTAACGGTGATGCTCTGACATTCACTACTACATTTA
CTCTGCAAGATGTATCCAATGACTTTGAAATAAATATTGAAGTTTACAGCTTGGTGCAAAAGAAAGATCCCTCAGGCCTTGATAAGAAGA
AAAAAACATCCAAGTCCAAGGCTATTACTCCAAAGCGACTCCTCACATCTATAACCACAAAAAGCAACATTCATTCTTCAGTCATGGCCA
GTCCAGGAGGTCTTAGTGCTGTGCGAACCAGCAACTTCGCCCTTGTTGGATCTTACACATTATCATTGTCTTCAGTAGGAAATACTAAGT
TTGTTCTGGACAAGGTCCCCTTTTTATCTTCTTTGGAAGGTCATATTTATTTAAAAATAAAATGTCAAGTGAATTCCAGTGTTGAAGAAA
GAGGTTTTCTAACCATATTTGAAGATGTTAGTGGTTTTGGTGCCTGGCATCGAAGATGGTGTGTTCTTTCTGGAAACTGTATATCTTATT
GGACTTATCCAGATGATGAGAAACGCAAGAATCCCATAGGAAGGATAAATCTGGCTAATTGTACCAGTCGTCAGATAGAACCAGCCAACA
GAGAATTTTGTGCAAGACGCAACACTTTTGAATTAATTACTGTCCGACCACAAAGAGAAGATGACCGAGAGACTCTTGTCAGCCAATGCA
GGGACACACTCTGTGTTACCAAGAACTGGCTGTCTGCAGATACTAAAGAAGAGCGGGATCTCTGGATGCAAAAACTCAATCAAGTTCTTG
TTGATATTCGCCTCTGGCAACCTGATGCTTGCTACAAACCTATTGGAAAGCCTTAAACCGGGAAATTTCCATGCTATCTAGAGGTTTTTG
ATGTCATCTTAAGAAACACACTTAAGAGCATCAGATTTACTGATTGCATTTTATGCTTTAAGTACGAAAGGGTTTGTGCCAATATTCACT
ACGTATTATGCAGTATTTATATCTTTTGTATGTAAAACTTTAACTGATTTCTGTCATTCATCAATGAGTAGAAGTAAATACATTATAGTT
GATTTTGCTAAATCTTAATTTAAAAGCCTCATTTTCCTAGAAATCTAATTATTCAGTTATTCATGACAATATTTTTTTAAAAGTAAGAAA
TTCTGAGTTGTCTTCTTGGAGCTGTAGGTCTTGAAGCAGCAACGTCTTTCAGGGGTTGGAGACAGAAACCCATTCTCCAATCTCAGTAGT
TTTTTCGAAAGGCTGTGATCATTTATTGATCGTGATATGACTTGTTACTAGGGTACTGAAAAAAATGTCTAAGGCCTTTACAGAAACATT
TTTAGTAATGAGGATGAGAACTTTTTCAAATAGCAAATATATATTGGCTTAAAGCATGAGGCTGTCTTCAGAAAAGTGATGTGGACATAG
GAGGCAATGTGTGAGACTTGGGGGTTCAATATTTTATATAGAAGAGTTAATAAGCACATGGTTTACATTTACTCAGCTACTATATATGCA
GTGTGGTGCACATTTTCACAGAATTCTGGCTTCATTAAGATCATTATTTTTGCTGCGTAGCTTACAGACTTAGCATATTAGTTTTTTCTA
CTCCTACAAGTGTAAATTGAAAAATCTTTATATTAAAAAAGTAAACTGTTATGAAGCTGCTATGTACTAATAATACTTTGCTTGCCAAAG
TGTTTGGGTTTTGTTGTTGTTTGTTTGTTTGTTTGTTTTTGGTTCATGAACAACAGTGTCTAGAAACCCATTTTGAAAGTGGAAAATTAT
TAAGTCACCTATCACCTTTAAACGCCTTTTTTTAAAATTATAAAATATTGTAAAGCAGGGTCTCAACTTTTAAATACACTTTGAACTTCT
TCTCTGAATTATTAAAGTTCTTTATGACCTCATTTATAAACACTAAATTCTGTCACCTCCTGTCATTTTATTTTTTATTCATTCAAATGT

>93461_93461_1_TPST1-ANLN_TPST1_chr7_65751696_ENST00000304842_ANLN_chr7_36435874_ENST00000265748_length(amino acids)=1466AA_BP=348
MVGKLKQNLLLACLVISSVTVFYLGQHAMECHHRIEERSQPVKLESTRTTVRTGLDLKANKTFAYHKDMPLIFIGGVPRSGTTLMRAMLD
AHPDIRCGEETRVIPRILALKQMWSRSSKEKIRLDEAGVTDEVLDSAMQAFLLEIIVKHGEPAPYLCNKDPFALKSLTYLSRLFPNAKFL
LMVRDGRASVHSMISRKVTIAGFDLNSYRDCLTKWNRAIETMYNQCMEVGYKKCMLVHYEQLVLHPERWMRTLLKFLQIPWNHSVLHHEE
MIGKAGGVSLSKVERSTDQVIKPVNVGALSKWVGKIPPDVLQDMAVIAPMLAKLGYDPYANPPNYGKPDPKIIENTRRKLLERTRARREN
LQRKMAERPTAAPRSMTHAKRARQPLSEASNQQPLSGGEEKSCTKPSPSKKRCSDNTEVEVSNLENKQPVESTSAKSCSPSPVSPQVQPQ
AADTISDSVAVPASLLGMRRGLNSRLEATAASSVKTRMQKLAEQRRRWDNDDMTDDIPESSLFSPMPSEEKAASPPRPLLSNASATPVGR
RGRLANLAATICSWEDDVNHSFAKQNSVQEQPGTACLSKFSSASGASARINSSSVKQEATFCSQRDGDASLNKALSSSADDASLVNASIS
SSVKATSPVKSTTSITDAKSCEGQNPELLPKTPISPLKTGVSKPIVKSTLSQTVPSKGELSREICLQSQSKDKSTTPGGTGIKPFLERFG
ERCQEHSKESPARSTPHRTPIITPNTKAIQERLFKQDTSSSTTHLAQQLKQERQKELACLRGRFDKGNIWSAEKGGNSKSKQLETKQETH
CQSTPLKKHQGVSKTQSLPVTEKVTENQIPAKNSSTEPKGFTECEMTKSSPLKITLFLEEDKSLKVTSDPKVEQKIEVIREIEMSVDDDD
INSSKVINDLFSDVLEEGELDMEKSQEEMDQALAESSEEQEDALNISSMSLLAPLAQTVGVVSPESLVSTPRLELKDTSRSDESPKPGKF
QRTRVPRAESGDSLGSEDRDLLYSIDAYRSQRFKETERPSIKQVIVRKEDVTSKLDEKNNAFPCQVNIKQKMQELNNEINMQQTVIYQAS
QALNCCVDEEHGKGSLEEAEAERLLLIATGKRTLLIDELNKLKNEGPQRKNKASPQSEFMPSKGSVTLSEIRLPLKADFVCSTVQKPDAA
NYYYLIILKAGAENMVATPLASTSNSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQKKDPSGLDKKKKTSKSKAITPKRLLTSITTKS
NIHSSVMASPGGLSAVRTSNFALVGSYTLSLSSVGNTKFVLDKVPFLSSLEGHIYLKIKCQVNSSVEERGFLTIFEDVSGFGAWHRRWCV
LSGNCISYWTYPDDEKRKNPIGRINLANCTSRQIEPANREFCARRNTFELITVRPQREDDRETLVSQCRDTLCVTKNWLSADTKEERDLW

--------------------------------------------------------------
>93461_93461_2_TPST1-ANLN_TPST1_chr7_65751696_ENST00000304842_ANLN_chr7_36435874_ENST00000396068_length(transcript)=5906nt_BP=1469nt
TCCTTCGGTGGGCAGCCGGCCGGAACTCACGAATCAGAGCAGCCGACACATCGTCCGCTCAGCCAATCGTAGCAGATGTGTGATCCCGCC
ACCTCCCCGGACCCTGGCGGTTGTCGCTGAGTTGGCGACCGCGGGAGACGCTGCTGAGGCGGCTTCGGTTGCGGGTCGGAACGGCGCTGC
TCTGCGGGGCCGGTCCAGGCTGGCAGCTGCCGGCGCTTGGCGGTGAGGGCGGGCTCCCGAGTGGCCCCCCACCGAAGGCGGTGGGACCAG
CGGCTGAGGCCAGGATGCCGTCCAGGCGGCGCGGCGGCTCCTCACTCATCCCAGATGTTGGTTATCTTTCTGAAGTAGACTGTCCATGGC
CTGAACATTTTCCGAAAATCATTTTGAGCAAAATATCTGTTTAATAACAAGATAACCACATCAAGATGGTTGGAAAGCTGAAGCAGAACT
TACTATTGGCATGTCTGGTGATTAGTTCTGTGACTGTGTTTTACCTGGGCCAGCATGCCATGGAATGCCATCACCGGATAGAGGAACGTA
GCCAGCCAGTCAAATTGGAGAGCACAAGGACCACTGTGAGAACTGGCCTGGACCTCAAAGCCAACAAAACCTTTGCCTATCACAAAGATA
TGCCTTTAATATTTATTGGAGGTGTGCCTCGGAGTGGAACCACACTCATGAGGGCCATGCTGGACGCACATCCTGACATTCGCTGTGGAG
AGGAAACCAGGGTCATTCCCCGAATCCTGGCCCTGAAGCAGATGTGGTCACGGTCAAGTAAAGAGAAGATCCGCCTGGATGAGGCTGGTG
TTACTGATGAAGTGCTGGATTCTGCCATGCAAGCCTTCTTACTAGAAATTATCGTTAAGCATGGGGAGCCAGCCCCTTATTTATGTAATA
AAGATCCTTTTGCCCTGAAATCTTTAACTTACCTTTCTAGGTTATTCCCCAATGCCAAATTTCTCCTGATGGTCCGAGATGGCCGGGCAT
CAGTACATTCAATGATTTCTCGAAAAGTTACTATAGCTGGATTTGATCTGAACAGCTATAGGGACTGTTTGACAAAGTGGAATCGTGCTA
TAGAGACCATGTATAACCAGTGTATGGAGGTTGGTTATAAAAAGTGCATGTTGGTTCACTATGAACAACTTGTCTTACATCCTGAACGGT
GGATGAGAACACTCTTAAAGTTCCTCCAGATTCCATGGAACCACTCAGTATTGCACCATGAAGAGATGATTGGGAAAGCTGGGGGAGTGT
CTCTGTCAAAAGTGGAGAGATCTACAGACCAAGTAATCAAGCCAGTCAATGTAGGAGCTCTATCAAAATGGGTTGGGAAGATACCGCCAG
ATGTTTTACAAGACATGGCAGTGATTGCTCCTATGCTTGCCAAGCTTGGATATGACCCATATGCCAACCCACCTAACTACGGAAAACCTG
ATCCCAAAATTATTGAAAACACTCGAAGGAAACTGCTGGAGCGAACCCGTGCCAGGCGAGAGAATCTTCAGAGAAAAATGGCTGAGAGGC
CCACAGCAGCTCCAAGGTCTATGACTCATGCTAAGCGAGCTAGACAGCCACTTTCAGAAGCAAGTAACCAGCAGCCCCTCTCTGGTGGTG
AAGAGAAATCTTGTACAAAACCATCGCCATCAAAAAAACGCTGTTCTGACAACACTGAAGTAGAAGTTTCTAACTTGGAAAATAAACAAC
CAGTTGAGTCGACATCTGCAAAATCTTGTTCTCCAAGTCCTGTGTCTCCTCAGGTGCAGCCACAAGCAGCAGATACCATCAGTGATTCTG
TTGCTGTCCCGGCATCACTGCTGGGCATGAGGAGAGGGCTGAACTCAAGATTGGAAGCAACTGCAGCCTCCTCAGTTAAAACACGTATGC
AAAAACTTGCAGAGCAACGGCGCCGTTGGGATAATGATGATATGACAGATGACATTCCTGAAAGCTCACTCTTCTCACCAATGCCATCAG
AGGAAAAGGCTGCTTCCCCTCCCAGACCTCTGCTTTCAAATGCCTCGGCAACTCCAGTTGGCAGAAGGGGCCGTCTGGCCAATCTTGCTG
CAACTATTTGCTCCTGGGAAGATGATGTAAATCACTCATTTGCAAAACAAAACAGTGTACAAGAACAGCCTGGTACCGCTTGTTTATCCA
AATTTTCCTCTGCAAGTGGAGCATCTGCTAGGATCAATAGCAGCAGTGTTAAGCAGGAAGCTACATTCTGTTCCCAAAGGGATGGCGATG
CCTCTTTGAATAAAGCCCTATCCTCAAGTGCTGATGATGCGTCTTTGGTTAATGCCTCAATTTCCAGCTCTGTGAAAGCTACTTCTCCAG
TGAAATCTACTACATCTATCACTGATGCTAAAAGTTGTGAGGGACAAAATCCTGAGCTACTTCCAAAAACTCCTATTAGTCCTCTGAAAA
CGGGGGTATCGAAACCAATTGTGAAGTCAACTTTATCCCAGACAGTTCCATCCAAGGGAGAATTAAGTAGAGAAATTTGTCTGCAATCTC
AATCTAAAGACAAATCTACGACACCAGGAGGAACAGGAATTAAGCCTTTCCTGGAACGCTTTGGAGAGCGTTGTCAAGAACATAGCAAAG
AAAGTCCAGCTCGTAGCACACCCCACAGAACCCCCATTATTACTCCAAATACAAAGGCCATCCAAGAAAGATTATTCAAGCAAGACACAT
CTTCATCTACTACCCATTTAGCACAACAGCTCAAGCAGGAACGTCAAAAAGAACTAGCATGTCTTCGTGGCCGATTTGACAAGGGCAATA
TATGGAGTGCAGAAAAAGGCGGAAACTCAAAAAGCAAACAACTAGAAACCAAACAGGAAACTCACTGTCAGAGCACTCCCCTCAAAAAAC
ACCAAGGTGTTTCAAAAACTCAGTCACTTCCAGTAACAGAAAAGGTGACCGAAAACCAGATACCAGCCAAAAATTCTAGTACAGAACCTA
AAGAAGTGATACGTGAAATTGAGATGAGTGTGGATGATGATGATATCAATAGTTCGAAAGTAATTAATGACCTCTTCAGTGATGTCCTAG
AGGAAGGTGAACTAGATATGGAGAAGAGCCAAGAGGAGATGGATCAAGCATTAGCAGAAAGCAGCGAAGAACAGGAAGATGCACTGAATA
TCTCCTCAATGTCTTTACTTGCACCATTGGCACAAACAGTTGGTGTGGTAAGTCCAGAGAGTTTAGTGTCCACACCTAGACTGGAATTGA
AAGACACCAGCAGAAGTGATGAAAGTCCAAAACCAGGAAAATTCCAAAGAACTCGTGTCCCTCGAGCTGAATCTGGTGATAGCCTTGGTT
CTGAAGATCGTGATCTTCTTTACAGCATTGATGCATATAGATCTCAAAGATTCAAAGAAACAGAACGTCCATCAATAAAGCAGGTGATTG
TTCGGAAGGAAGATGTTACTTCAAAACTGGATGAAAAAAATAATGCCTTTCCTTGTCAAGTTAATATCAAACAGAAAATGCAGGAACTCA
ATAACGAAATAAATATGCAACAGACAGTGATCTATCAAGCTAGCCAGGCTCTTAACTGCTGTGTTGATGAAGAACATGGAAAAGGGTCCC
TAGAAGAAGCTGAAGCAGAAAGACTTCTTCTAATTGCAACTGGGAAGAGAACACTTTTGATTGATGAATTGAATAAATTGAAGAACGAAG
GACCTCAGAGGAAGAATAAGGCTAGTCCCCAAAGTGAATTTATGCCATCCAAAGGATCAGTTACTTTGTCAGAAATCCGCTTGCCTCTAA
AAGCAGATTTTGTCTGCAGTACGGTTCAGAAACCAGATGCAGCAAATTACTATTACTTAATTATACTAAAAGCAGGAGCTGAAAATATGG
TAGCCACACCATTAGCAAGTACTTCAAACTCTCTTAACGGTGATGCTCTGACATTCACTACTACATTTACTCTGCAAGATGTATCCAATG
ACTTTGAAATAAATATTGAAGTTTACAGCTTGGTGCAAAAGAAAGATCCCTCAGGCCTTGATAAGAAGAAAAAAACATCCAAGTCCAAGG
CTATTACTCCAAAGCGACTCCTCACATCTATAACCACAAAAAGCAACATTCATTCTTCAGTCATGGCCAGTCCAGGAGGTCTTAGTGCTG
TGCGAACCAGCAACTTCGCCCTTGTTGGATCTTACACATTATCATTGTCTTCAGTAGGAAATACTAAGTTTGTTCTGGACAAGGTCCCCT
TTTTATCTTCTTTGGAAGGTCATATTTATTTAAAAATAAAATGTCAAGTGAATTCCAGTGTTGAAGAAAGAGGTTTTCTAACCATATTTG
AAGATGTTAGTGGTTTTGGTGCCTGGCATCGAAGATGGTGTGTTCTTTCTGGAAACTGTATATCTTATTGGACTTATCCAGATGATGAGA
AACGCAAGAATCCCATAGGAAGGATAAATCTGGCTAATTGTACCAGTCGTCAGATAGAACCAGCCAACAGAGAATTTTGTGCAAGACGCA
ACACTTTTGAATTAATTACTGTCCGACCACAAAGAGAAGATGACCGAGAGACTCTTGTCAGCCAATGCAGGGACACACTCTGTGTTACCA
AGAACTGGCTGTCTGCAGATACTAAAGAAGAGCGGGATCTCTGGATGCAAAAACTCAATCAAGTTCTTGTTGATATTCGCCTCTGGCAAC
CTGATGCTTGCTACAAACCTATTGGAAAGCCTTAAACCGGGAAATTTCCATGCTATCTAGAGGTTTTTGATGTCATCTTAAGAAACACAC
TTAAGAGCATCAGATTTACTGATTGCATTTTATGCTTTAAGTACGAAAGGGTTTGTGCCAATATTCACTACGTATTATGCAGTATTTATA
TCTTTTGTATGTAAAACTTTAACTGATTTCTGTCATTCATCAATGAGTAGAAGTAAATACATTATAGTTGATTTTGCTAAATCTTAATTT
AAAAGCCTCATTTTCCTAGAAATCTAATTATTCAGTTATTCATGACAATATTTTTTTAAAAGTAAGAAATTCTGAGTTGTCTTCTTGGAG
CTGTAGGTCTTGAAGCAGCAACGTCTTTCAGGGGTTGGAGACAGAAACCCATTCTCCAATCTCAGTAGTTTTTTCGAAAGGCTGTGATCA
TTTATTGATCGTGATATGACTTGTTACTAGGGTACTGAAAAAAATGTCTAAGGCCTTTACAGAAACATTTTTAGTAATGAGGATGAGAAC
TTTTTCAAATAGCAAATATATATTGGCTTAAAGCATGAGGCTGTCTTCAGAAAAGTGATGTGGACATAGGAGGCAATGTGTGAGACTTGG
GGGTTCAATATTTTATATAGAAGAGTTAATAAGCACATGGTTTACATTTACTCAGCTACTATATATGCAGTGTGGTGCACATTTTCACAG
AATTCTGGCTTCATTAAGATCATTATTTTTGCTGCGTAGCTTACAGACTTAGCATATTAGTTTTTTCTACTCCTACAAGTGTAAATTGAA
AAATCTTTATATTAAAAAAGTAAACTGTTATGAAGCTGCTATGTACTAATAATACTTTGCTTGCCAAAGTGTTTGGGTTTTGTTGTTGTT
TGTTTGTTTGTTTGTTTTTGGTTCATGAACAACAGTGTCTAGAAACCCATTTTGAAAGTGGAAAATTATTAAGTCACCTATCACCTTTAA
ACGCCTTTTTTTAAAATTATAAAATATTGTAAAGCAGGGTCTCAACTTTTAAATACACTTTGAACTTCTTCTCTGAATTATTAAAGTTCT
TTATGACCTCATTTATAAACACTAAATTCTGTCACCTCCTGTCATTTTATTTTTTATTCATTCAAATGTATTTTTTCTTGTGCATATTAT

>93461_93461_2_TPST1-ANLN_TPST1_chr7_65751696_ENST00000304842_ANLN_chr7_36435874_ENST00000396068_length(amino acids)=1429AA_BP=348
MVGKLKQNLLLACLVISSVTVFYLGQHAMECHHRIEERSQPVKLESTRTTVRTGLDLKANKTFAYHKDMPLIFIGGVPRSGTTLMRAMLD
AHPDIRCGEETRVIPRILALKQMWSRSSKEKIRLDEAGVTDEVLDSAMQAFLLEIIVKHGEPAPYLCNKDPFALKSLTYLSRLFPNAKFL
LMVRDGRASVHSMISRKVTIAGFDLNSYRDCLTKWNRAIETMYNQCMEVGYKKCMLVHYEQLVLHPERWMRTLLKFLQIPWNHSVLHHEE
MIGKAGGVSLSKVERSTDQVIKPVNVGALSKWVGKIPPDVLQDMAVIAPMLAKLGYDPYANPPNYGKPDPKIIENTRRKLLERTRARREN
LQRKMAERPTAAPRSMTHAKRARQPLSEASNQQPLSGGEEKSCTKPSPSKKRCSDNTEVEVSNLENKQPVESTSAKSCSPSPVSPQVQPQ
AADTISDSVAVPASLLGMRRGLNSRLEATAASSVKTRMQKLAEQRRRWDNDDMTDDIPESSLFSPMPSEEKAASPPRPLLSNASATPVGR
RGRLANLAATICSWEDDVNHSFAKQNSVQEQPGTACLSKFSSASGASARINSSSVKQEATFCSQRDGDASLNKALSSSADDASLVNASIS
SSVKATSPVKSTTSITDAKSCEGQNPELLPKTPISPLKTGVSKPIVKSTLSQTVPSKGELSREICLQSQSKDKSTTPGGTGIKPFLERFG
ERCQEHSKESPARSTPHRTPIITPNTKAIQERLFKQDTSSSTTHLAQQLKQERQKELACLRGRFDKGNIWSAEKGGNSKSKQLETKQETH
CQSTPLKKHQGVSKTQSLPVTEKVTENQIPAKNSSTEPKEVIREIEMSVDDDDINSSKVINDLFSDVLEEGELDMEKSQEEMDQALAESS
EEQEDALNISSMSLLAPLAQTVGVVSPESLVSTPRLELKDTSRSDESPKPGKFQRTRVPRAESGDSLGSEDRDLLYSIDAYRSQRFKETE
RPSIKQVIVRKEDVTSKLDEKNNAFPCQVNIKQKMQELNNEINMQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATGKRTLLID
ELNKLKNEGPQRKNKASPQSEFMPSKGSVTLSEIRLPLKADFVCSTVQKPDAANYYYLIILKAGAENMVATPLASTSNSLNGDALTFTTT
FTLQDVSNDFEINIEVYSLVQKKDPSGLDKKKKTSKSKAITPKRLLTSITTKSNIHSSVMASPGGLSAVRTSNFALVGSYTLSLSSVGNT
KFVLDKVPFLSSLEGHIYLKIKCQVNSSVEERGFLTIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKNPIGRINLANCTSRQIEPA

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Fusion Gene PPI Analysis for TPST1-ANLN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneTPST1chr7:65751696chr7:36435874ENST00000304842+36102_106348.0446.0peptide substrate
TgeneANLNchr7:65751696chr7:36435874ENST00000265748024231_6766.01125.0F-actin
TgeneANLNchr7:65751696chr7:36435874ENST00000396068023231_6766.01088.0F-actin


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneANLNchr7:65751696chr7:36435874ENST000002657480241_1556.01125.0CD2AP
TgeneANLNchr7:65751696chr7:36435874ENST000003960680231_1556.01088.0CD2AP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TPST1-ANLN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TPST1-ANLN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource