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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TPX2-HM13 (FusionGDB2 ID:93558)

Fusion Gene Summary for TPX2-HM13

check button Fusion gene summary
Fusion gene informationFusion gene name: TPX2-HM13
Fusion gene ID: 93558
HgeneTgene
Gene symbol

TPX2

HM13

Gene ID

22974

81502

Gene nameTPX2 microtubule nucleation factorhistocompatibility minor 13
SynonymsC20orf1|C20orf2|DIL-2|DIL2|FLS353|GD:C20orf1|HCA519|HCTP4|REPP86|p100H13|IMP1|IMPAS|IMPAS-1|MSTP086|PSENL3|PSL3|SPP|SPPL1
Cytomap

20q11.21

20q11.21

Type of geneprotein-codingprotein-coding
Descriptiontargeting protein for Xklp2TPX2, microtubule-associated protein homologTPX2, microtubule-associated, homologdifferentially expressed in cancerous and non-cancerous lung cells 2differentially expressed in lung cellshepatocellular carcinoma-associated minor histocompatibility antigen H13intramembrane protease 1minor histocompatibility antigen 13presenilin-like protein 3signal peptide peptidase betasignal peptide peptidase like 1
Modification date2020031320200313
UniProtAcc.

Q8TCT9

Ensembl transtripts involved in fusion geneENST00000300403, ENST00000340513, 
ENST00000492709, ENST00000335574, 
ENST00000340852, ENST00000376127, 
ENST00000398174, 
Fusion gene scores* DoF score21 X 15 X 15=472516 X 19 X 12=3648
# samples 4025
** MAII scorelog2(40/4725*10)=-3.56224242422107
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/3648*10)=-3.86710572950266
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TPX2 [Title/Abstract] AND HM13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTPX2(30327424)-HM13(30115287), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTPX2

GO:0007020

microtubule nucleation

26414402

HgeneTPX2

GO:0007026

negative regulation of microtubule depolymerization

26414402

HgeneTPX2

GO:0032147

activation of protein kinase activity

14580337|19801554

HgeneTPX2

GO:0090307

mitotic spindle assembly

26165940

TgeneHM13

GO:0033619

membrane protein proteolysis

14741365


check buttonFusion gene breakpoints across TPX2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HM13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GC-A3I6-01ATPX2chr20

30327424

-HM13chr20

30115287

+
ChimerDB4BLCATCGA-GC-A3I6-01ATPX2chr20

30327424

+HM13chr20

30115287

+
ChimerDB4BLCATCGA-GC-A3I6TPX2chr20

30327424

+HM13chr20

30115286

+
ChimerDB4BLCATCGA-GV-A3JW-01ATPX2chr20

30327424

+HM13chr20

30115287

+
ChimerDB4CESCTCGA-DS-A0VK-01ATPX2chr20

30347982

+HM13chr20

30142549

+
ChimerDB4LUADTCGA-38-4630-01ATPX2chr20

30327424

+HM13chr20

30102284

+
ChimerDB4LUADTCGA-38-4630-01ATPX2chr20

30330449

+HM13chr20

30102283

+
ChimerDB4LUADTCGA-38-4630-01ATPX2chr20

30330450

+HM13chr20

30102284

+
ChimerDB4READTCGA-AG-A01NTPX2chr20

30330450

+HM13chr20

30115287

+
ChimerDB4STADTCGA-CG-5732TPX2chr20

30347982

+HM13chr20

30136831

+
ChimerDB4UCECTCGA-B5-A3FH-01ATPX2chr20

30330449

+HM13chr20

30154012

+
ChimerDB4UCECTCGA-B5-A3FH-01ATPX2chr20

30330450

-HM13chr20

30154013

+
ChimerDB4UCECTCGA-B5-A3FH-01ATPX2chr20

30330450

+HM13chr20

30154013

+
ChimerDB4UCECTCGA-B5-A3FH-01ATPX2chr20

30330450

+HM13chr20

30156923

+
ChimerDB4UCECTCGA-EY-A3QX-01ATPX2chr20

30330449

+HM13chr20

30102283

+
ChimerDB4UCECTCGA-EY-A3QX-01ATPX2chr20

30330450

+HM13chr20

30102284

+


Top

Fusion Gene ORF analysis for TPX2-HM13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000300403ENST00000492709TPX2chr20

30347982

+HM13chr20

30142549

+
5CDS-3UTRENST00000300403ENST00000492709TPX2chr20

30347982

+HM13chr20

30136831

+
5CDS-3UTRENST00000340513ENST00000492709TPX2chr20

30347982

+HM13chr20

30142549

+
5CDS-3UTRENST00000340513ENST00000492709TPX2chr20

30347982

+HM13chr20

30136831

+
5UTR-3CDSENST00000300403ENST00000335574TPX2chr20

30327424

+HM13chr20

30115286

+
5UTR-3CDSENST00000300403ENST00000335574TPX2chr20

30327424

+HM13chr20

30115287

+
5UTR-3CDSENST00000300403ENST00000335574TPX2chr20

30330450

+HM13chr20

30115287

+
5UTR-3CDSENST00000300403ENST00000335574TPX2chr20

30330449

+HM13chr20

30154012

+
5UTR-3CDSENST00000300403ENST00000335574TPX2chr20

30330450

+HM13chr20

30154013

+
5UTR-3CDSENST00000300403ENST00000340852TPX2chr20

30327424

+HM13chr20

30115286

+
5UTR-3CDSENST00000300403ENST00000340852TPX2chr20

30327424

+HM13chr20

30115287

+
5UTR-3CDSENST00000300403ENST00000340852TPX2chr20

30330450

+HM13chr20

30115287

+
5UTR-3CDSENST00000300403ENST00000340852TPX2chr20

30330449

+HM13chr20

30154012

+
5UTR-3CDSENST00000300403ENST00000340852TPX2chr20

30330450

+HM13chr20

30154013

+
5UTR-3CDSENST00000300403ENST00000340852TPX2chr20

30330450

+HM13chr20

30156923

+
5UTR-3CDSENST00000300403ENST00000376127TPX2chr20

30327424

+HM13chr20

30115286

+
5UTR-3CDSENST00000300403ENST00000376127TPX2chr20

30327424

+HM13chr20

30115287

+
5UTR-3CDSENST00000300403ENST00000376127TPX2chr20

30330450

+HM13chr20

30115287

+
5UTR-3CDSENST00000300403ENST00000376127TPX2chr20

30330449

+HM13chr20

30154012

+
5UTR-3CDSENST00000300403ENST00000376127TPX2chr20

30330450

+HM13chr20

30154013

+
5UTR-3CDSENST00000300403ENST00000398174TPX2chr20

30327424

+HM13chr20

30115286

+
5UTR-3CDSENST00000300403ENST00000398174TPX2chr20

30327424

+HM13chr20

30115287

+
5UTR-3CDSENST00000300403ENST00000398174TPX2chr20

30330450

+HM13chr20

30115287

+
5UTR-3CDSENST00000300403ENST00000398174TPX2chr20

30330449

+HM13chr20

30154012

+
5UTR-3CDSENST00000300403ENST00000398174TPX2chr20

30330450

+HM13chr20

30154013

+
5UTR-3CDSENST00000300403ENST00000398174TPX2chr20

30330450

+HM13chr20

30156923

+
5UTR-3CDSENST00000340513ENST00000335574TPX2chr20

30327424

+HM13chr20

30115286

+
5UTR-3CDSENST00000340513ENST00000335574TPX2chr20

30327424

+HM13chr20

30115287

+
5UTR-3CDSENST00000340513ENST00000335574TPX2chr20

30330450

+HM13chr20

30115287

+
5UTR-3CDSENST00000340513ENST00000335574TPX2chr20

30330449

+HM13chr20

30154012

+
5UTR-3CDSENST00000340513ENST00000335574TPX2chr20

30330450

+HM13chr20

30154013

+
5UTR-3CDSENST00000340513ENST00000340852TPX2chr20

30327424

+HM13chr20

30115286

+
5UTR-3CDSENST00000340513ENST00000340852TPX2chr20

30327424

+HM13chr20

30115287

+
5UTR-3CDSENST00000340513ENST00000340852TPX2chr20

30330450

+HM13chr20

30115287

+
5UTR-3CDSENST00000340513ENST00000340852TPX2chr20

30330449

+HM13chr20

30154012

+
5UTR-3CDSENST00000340513ENST00000340852TPX2chr20

30330450

+HM13chr20

30154013

+
5UTR-3CDSENST00000340513ENST00000340852TPX2chr20

30330450

+HM13chr20

30156923

+
5UTR-3CDSENST00000340513ENST00000376127TPX2chr20

30327424

+HM13chr20

30115286

+
5UTR-3CDSENST00000340513ENST00000376127TPX2chr20

30327424

+HM13chr20

30115287

+
5UTR-3CDSENST00000340513ENST00000376127TPX2chr20

30330450

+HM13chr20

30115287

+
5UTR-3CDSENST00000340513ENST00000376127TPX2chr20

30330449

+HM13chr20

30154012

+
5UTR-3CDSENST00000340513ENST00000376127TPX2chr20

30330450

+HM13chr20

30154013

+
5UTR-3CDSENST00000340513ENST00000398174TPX2chr20

30327424

+HM13chr20

30115286

+
5UTR-3CDSENST00000340513ENST00000398174TPX2chr20

30327424

+HM13chr20

30115287

+
5UTR-3CDSENST00000340513ENST00000398174TPX2chr20

30330450

+HM13chr20

30115287

+
5UTR-3CDSENST00000340513ENST00000398174TPX2chr20

30330449

+HM13chr20

30154012

+
5UTR-3CDSENST00000340513ENST00000398174TPX2chr20

30330450

+HM13chr20

30154013

+
5UTR-3CDSENST00000340513ENST00000398174TPX2chr20

30330450

+HM13chr20

30156923

+
5UTR-3UTRENST00000300403ENST00000335574TPX2chr20

30330450

+HM13chr20

30156923

+
5UTR-3UTRENST00000300403ENST00000376127TPX2chr20

30330450

+HM13chr20

30156923

+
5UTR-3UTRENST00000300403ENST00000492709TPX2chr20

30330449

+HM13chr20

30154012

+
5UTR-3UTRENST00000300403ENST00000492709TPX2chr20

30330450

+HM13chr20

30154013

+
5UTR-3UTRENST00000300403ENST00000492709TPX2chr20

30330450

+HM13chr20

30156923

+
5UTR-3UTRENST00000340513ENST00000335574TPX2chr20

30330450

+HM13chr20

30156923

+
5UTR-3UTRENST00000340513ENST00000376127TPX2chr20

30330450

+HM13chr20

30156923

+
5UTR-3UTRENST00000340513ENST00000492709TPX2chr20

30330449

+HM13chr20

30154012

+
5UTR-3UTRENST00000340513ENST00000492709TPX2chr20

30330450

+HM13chr20

30154013

+
5UTR-3UTRENST00000340513ENST00000492709TPX2chr20

30330450

+HM13chr20

30156923

+
5UTR-5UTRENST00000300403ENST00000335574TPX2chr20

30327424

+HM13chr20

30102284

+
5UTR-5UTRENST00000300403ENST00000335574TPX2chr20

30330449

+HM13chr20

30102283

+
5UTR-5UTRENST00000300403ENST00000335574TPX2chr20

30330450

+HM13chr20

30102284

+
5UTR-5UTRENST00000300403ENST00000340852TPX2chr20

30327424

+HM13chr20

30102284

+
5UTR-5UTRENST00000300403ENST00000340852TPX2chr20

30330449

+HM13chr20

30102283

+
5UTR-5UTRENST00000300403ENST00000340852TPX2chr20

30330450

+HM13chr20

30102284

+
5UTR-5UTRENST00000300403ENST00000376127TPX2chr20

30327424

+HM13chr20

30102284

+
5UTR-5UTRENST00000300403ENST00000376127TPX2chr20

30330449

+HM13chr20

30102283

+
5UTR-5UTRENST00000300403ENST00000376127TPX2chr20

30330450

+HM13chr20

30102284

+
5UTR-5UTRENST00000300403ENST00000398174TPX2chr20

30327424

+HM13chr20

30102284

+
5UTR-5UTRENST00000300403ENST00000398174TPX2chr20

30330449

+HM13chr20

30102283

+
5UTR-5UTRENST00000300403ENST00000398174TPX2chr20

30330450

+HM13chr20

30102284

+
5UTR-5UTRENST00000340513ENST00000335574TPX2chr20

30327424

+HM13chr20

30102284

+
5UTR-5UTRENST00000340513ENST00000335574TPX2chr20

30330449

+HM13chr20

30102283

+
5UTR-5UTRENST00000340513ENST00000335574TPX2chr20

30330450

+HM13chr20

30102284

+
5UTR-5UTRENST00000340513ENST00000340852TPX2chr20

30327424

+HM13chr20

30102284

+
5UTR-5UTRENST00000340513ENST00000340852TPX2chr20

30330449

+HM13chr20

30102283

+
5UTR-5UTRENST00000340513ENST00000340852TPX2chr20

30330450

+HM13chr20

30102284

+
5UTR-5UTRENST00000340513ENST00000376127TPX2chr20

30327424

+HM13chr20

30102284

+
5UTR-5UTRENST00000340513ENST00000376127TPX2chr20

30330449

+HM13chr20

30102283

+
5UTR-5UTRENST00000340513ENST00000376127TPX2chr20

30330450

+HM13chr20

30102284

+
5UTR-5UTRENST00000340513ENST00000398174TPX2chr20

30327424

+HM13chr20

30102284

+
5UTR-5UTRENST00000340513ENST00000398174TPX2chr20

30330449

+HM13chr20

30102283

+
5UTR-5UTRENST00000340513ENST00000398174TPX2chr20

30330450

+HM13chr20

30102284

+
5UTR-intronENST00000300403ENST00000492709TPX2chr20

30327424

+HM13chr20

30115286

+
5UTR-intronENST00000300403ENST00000492709TPX2chr20

30327424

+HM13chr20

30115287

+
5UTR-intronENST00000300403ENST00000492709TPX2chr20

30327424

+HM13chr20

30102284

+
5UTR-intronENST00000300403ENST00000492709TPX2chr20

30330449

+HM13chr20

30102283

+
5UTR-intronENST00000300403ENST00000492709TPX2chr20

30330450

+HM13chr20

30102284

+
5UTR-intronENST00000300403ENST00000492709TPX2chr20

30330450

+HM13chr20

30115287

+
5UTR-intronENST00000340513ENST00000492709TPX2chr20

30327424

+HM13chr20

30115286

+
5UTR-intronENST00000340513ENST00000492709TPX2chr20

30327424

+HM13chr20

30115287

+
5UTR-intronENST00000340513ENST00000492709TPX2chr20

30327424

+HM13chr20

30102284

+
5UTR-intronENST00000340513ENST00000492709TPX2chr20

30330449

+HM13chr20

30102283

+
5UTR-intronENST00000340513ENST00000492709TPX2chr20

30330450

+HM13chr20

30102284

+
5UTR-intronENST00000340513ENST00000492709TPX2chr20

30330450

+HM13chr20

30115287

+
In-frameENST00000300403ENST00000335574TPX2chr20

30347982

+HM13chr20

30142549

+
In-frameENST00000300403ENST00000335574TPX2chr20

30347982

+HM13chr20

30136831

+
In-frameENST00000300403ENST00000340852TPX2chr20

30347982

+HM13chr20

30142549

+
In-frameENST00000300403ENST00000340852TPX2chr20

30347982

+HM13chr20

30136831

+
In-frameENST00000300403ENST00000376127TPX2chr20

30347982

+HM13chr20

30142549

+
In-frameENST00000300403ENST00000376127TPX2chr20

30347982

+HM13chr20

30136831

+
In-frameENST00000300403ENST00000398174TPX2chr20

30347982

+HM13chr20

30142549

+
In-frameENST00000300403ENST00000398174TPX2chr20

30347982

+HM13chr20

30136831

+
In-frameENST00000340513ENST00000335574TPX2chr20

30347982

+HM13chr20

30142549

+
In-frameENST00000340513ENST00000335574TPX2chr20

30347982

+HM13chr20

30136831

+
In-frameENST00000340513ENST00000340852TPX2chr20

30347982

+HM13chr20

30142549

+
In-frameENST00000340513ENST00000340852TPX2chr20

30347982

+HM13chr20

30136831

+
In-frameENST00000340513ENST00000376127TPX2chr20

30347982

+HM13chr20

30142549

+
In-frameENST00000340513ENST00000376127TPX2chr20

30347982

+HM13chr20

30136831

+
In-frameENST00000340513ENST00000398174TPX2chr20

30347982

+HM13chr20

30142549

+
In-frameENST00000340513ENST00000398174TPX2chr20

30347982

+HM13chr20

30136831

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340513TPX2chr2030347982+ENST00000398174HM13chr2030136831+19327575011583360
ENST00000340513TPX2chr2030347982+ENST00000340852HM13chr2030136831+17857575011436311
ENST00000340513TPX2chr2030347982+ENST00000335574HM13chr2030136831+19887575011487328
ENST00000340513TPX2chr2030347982+ENST00000376127HM13chr2030136831+16347575011310269
ENST00000300403TPX2chr2030347982+ENST00000398174HM13chr2030136831+19327575011583360
ENST00000300403TPX2chr2030347982+ENST00000340852HM13chr2030136831+17857575011436311
ENST00000300403TPX2chr2030347982+ENST00000335574HM13chr2030136831+19887575011487328
ENST00000300403TPX2chr2030347982+ENST00000376127HM13chr2030136831+16347575011310269
ENST00000340513TPX2chr2030347982+ENST00000398174HM13chr2030142549+16627575011313270
ENST00000340513TPX2chr2030347982+ENST00000340852HM13chr2030142549+15157575011166221
ENST00000340513TPX2chr2030347982+ENST00000335574HM13chr2030142549+17187575011217238
ENST00000340513TPX2chr2030347982+ENST00000376127HM13chr2030142549+14907575011166221
ENST00000300403TPX2chr2030347982+ENST00000398174HM13chr2030142549+16627575011313270
ENST00000300403TPX2chr2030347982+ENST00000340852HM13chr2030142549+15157575011166221
ENST00000300403TPX2chr2030347982+ENST00000335574HM13chr2030142549+17187575011217238
ENST00000300403TPX2chr2030347982+ENST00000376127HM13chr2030142549+14907575011166221

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340513ENST00000398174TPX2chr2030347982+HM13chr2030136831+0.0031363070.9968637
ENST00000340513ENST00000340852TPX2chr2030347982+HM13chr2030136831+0.0024945320.9975055
ENST00000340513ENST00000335574TPX2chr2030347982+HM13chr2030136831+0.0041809630.99581903
ENST00000340513ENST00000376127TPX2chr2030347982+HM13chr2030136831+0.0024269680.9975731
ENST00000300403ENST00000398174TPX2chr2030347982+HM13chr2030136831+0.0031363070.9968637
ENST00000300403ENST00000340852TPX2chr2030347982+HM13chr2030136831+0.0024945320.9975055
ENST00000300403ENST00000335574TPX2chr2030347982+HM13chr2030136831+0.0041809630.99581903
ENST00000300403ENST00000376127TPX2chr2030347982+HM13chr2030136831+0.0024269680.9975731
ENST00000340513ENST00000398174TPX2chr2030347982+HM13chr2030142549+0.0052198080.9947802
ENST00000340513ENST00000340852TPX2chr2030347982+HM13chr2030142549+0.0023785360.9976215
ENST00000340513ENST00000335574TPX2chr2030347982+HM13chr2030142549+0.0050914880.9949085
ENST00000340513ENST00000376127TPX2chr2030347982+HM13chr2030142549+0.0024726040.9975274
ENST00000300403ENST00000398174TPX2chr2030347982+HM13chr2030142549+0.0052198080.9947802
ENST00000300403ENST00000340852TPX2chr2030347982+HM13chr2030142549+0.0023785360.9976215
ENST00000300403ENST00000335574TPX2chr2030347982+HM13chr2030142549+0.0050914880.9949085
ENST00000300403ENST00000376127TPX2chr2030347982+HM13chr2030142549+0.0024726040.9975274

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Fusion Genomic Features for TPX2-HM13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TPX2chr2030330450+HM13chr2030156922+3.23E-050.9999677
TPX2chr2030330450+HM13chr2030154012+4.17E-060.9999958
TPX2chr2030327424+HM13chr2030115286+1.35E-111
TPX2chr2030347982+HM13chr2030136831+1.24E-091
TPX2chr2030327424+HM13chr2030115286+1.35E-111
TPX2chr2030347982+HM13chr2030142548+1.06E-121
TPX2chr2030330450+HM13chr2030115286+1.84E-101
TPX2chr2030330450+HM13chr2030156922+3.23E-050.9999677
TPX2chr2030330450+HM13chr2030154012+4.17E-060.9999958
TPX2chr2030327424+HM13chr2030115286+1.35E-111
TPX2chr2030347982+HM13chr2030136831+1.24E-091
TPX2chr2030327424+HM13chr2030115286+1.35E-111
TPX2chr2030347982+HM13chr2030142548+1.06E-121
TPX2chr2030330450+HM13chr2030115286+1.84E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TPX2-HM13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:30327424/chr20:30115287)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HM13

Q8TCT9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity). {ECO:0000250|UniProtKB:Q9D8V0, ECO:0000269|PubMed:11714810, ECO:0000269|PubMed:12077416, ECO:0000269|PubMed:12145199, ECO:0000269|PubMed:14741365, ECO:0000269|PubMed:25239945}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313317_319151442.0MotifNote=PAL
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312317_319151378.0MotifNote=PAL
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311317_319151336.0MotifNote=PAL
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313317_319151427.0MotifNote=PAL
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613317_319241442.0MotifNote=PAL
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612317_319241378.0MotifNote=PAL
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511317_319199336.0MotifNote=PAL
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613317_319241427.0MotifNote=PAL
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313179_181151442.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313203_209151442.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313231_256151442.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313278_290151442.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313312_314151442.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313336_377151442.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312179_181151378.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312203_209151378.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312231_256151378.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312278_290151378.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312312_314151378.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312336_377151378.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311179_181151336.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311203_209151336.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311231_256151336.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311278_290151336.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311312_314151336.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311336_377151336.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313179_181151427.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313203_209151427.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313231_256151427.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313278_290151427.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313312_314151427.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313336_377151427.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613278_290241442.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613312_314241442.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613336_377241442.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612278_290241378.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612312_314241378.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612336_377241378.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511203_209199336.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511231_256199336.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511278_290199336.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511312_314199336.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511336_377199336.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613278_290241427.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613312_314241427.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613336_377241427.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313158_178151442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313182_202151442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313210_230151442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313257_277151442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313291_311151442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313315_335151442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312158_178151378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312182_202151378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312210_230151378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312257_277151378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312291_311151378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312315_335151378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311158_178151336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311182_202151336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311210_230151336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311257_277151336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311291_311151336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311315_335151336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313158_178151427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313182_202151427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313210_230151427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313257_277151427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313291_311151427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313315_335151427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613257_277241442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613291_311241442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613315_335241442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612257_277241378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612291_311241378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612315_335241378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511210_230199336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511257_277199336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511291_311199336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511315_335199336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613257_277241427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613291_311241427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613315_335241427.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313122_157151442.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST000003355743131_31151442.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST0000033557431353_77151442.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST0000033557431399_100151442.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312122_157151378.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST000003408523121_31151378.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST0000034085231253_77151378.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST0000034085231299_100151378.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311122_157151336.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST000003761273111_31151336.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST0000037612731153_77151336.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST0000037612731199_100151336.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313122_157151427.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST000003981743131_31151427.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST0000039817431353_77151427.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30136831ENST0000039817431399_100151427.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613122_157241442.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613179_181241442.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST000003355746131_31241442.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613203_209241442.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613231_256241442.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST0000033557461353_77241442.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST0000033557461399_100241442.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612122_157241378.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612179_181241378.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST000003408526121_31241378.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612203_209241378.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612231_256241378.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST0000034085261253_77241378.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST0000034085261299_100241378.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511122_157199336.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511179_181199336.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST000003761275111_31199336.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST0000037612751153_77199336.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST0000037612751199_100199336.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613122_157241427.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613179_181241427.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST000003981746131_31241427.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613203_209241427.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613231_256241427.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30142549ENST0000039817461353_77241427.0Topological domainCytoplasmic
TgeneHM13chr20:30347982chr20:30142549ENST0000039817461399_100241427.0Topological domainLumenal
TgeneHM13chr20:30347982chr20:30136831ENST00000335574313101_121151442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST0000033557431332_52151442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST0000033557431378_98151442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000340852312101_121151378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST0000034085231232_52151378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST0000034085231278_98151378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000376127311101_121151336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST0000037612731132_52151336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST0000037612731178_98151336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST00000398174313101_121151427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST0000039817431332_52151427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30136831ENST0000039817431378_98151427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613101_121241442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613158_178241442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613182_202241442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000335574613210_230241442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST0000033557461332_52241442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST0000033557461378_98241442.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612101_121241378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612158_178241378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612182_202241378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000340852612210_230241378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST0000034085261232_52241378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST0000034085261278_98241378.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511101_121199336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511158_178199336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000376127511182_202199336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST0000037612751132_52199336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST0000037612751178_98199336.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613101_121241427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613158_178241427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613182_202241427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST00000398174613210_230241427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST0000039817461332_52241427.0TransmembraneHelical
TgeneHM13chr20:30347982chr20:30142549ENST0000039817461378_98241427.0TransmembraneHelical


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Fusion Gene Sequence for TPX2-HM13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>93558_93558_1_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30136831_ENST00000335574_length(transcript)=1988nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGAGATCATCAATTATGAATTTGACACCAAGGACCTGGTGTGCCTGGGCCTGAGC
AGCATCGTTGGCGTCTGGTACCTGCTGAGGAAGCACTGGATTGCCAACAACCTTTTTGGCCTGGCCTTCTCCCTTAATGGAGTAGAGCTC
CTGCACCTCAACAATGTCAGCACTGGCTGCATCCTGCTGGGCGGACTCTTCATCTACGATGTCTTCTGGGTATTTGGCACCAATGTGATG
GTGACAGTGGCCAAGTCCTTCGAGGCACCAATAAAATTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCC
ATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATCTTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACC
TACTTCTACACCAGCTTTGCAGCCTACATCTTCGGCCTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTC
CTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTCCTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGCTACGAGTCCTCG
GCGGAAATCCTGCCTCATACCCCGAGGCTCACCCACTTCCCCACAGTCTCGGGCTCCCCAGCCAGCCTGGCCGACTCCATGCAGCAGAAG
CTAGCTGGCCCTCGCCGCCGGCGCCCGCAGAATCCCAGCGCCATGTAATGCCCAGCGGGTGCCCACCTGCCCGCTTCCCCCTACTGCCCC
GGGGCCCAAGTTATGAGGAGTCAAATCCTAAGGATCCAGCGGCAGTGACAGAATCCAAAGAGGGAACAGAGGCATCAGCATCGAAGGGGC
TGGAGAAGAAAGAGAAATGATGCAGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAGACAGATGGGGGCTGGGCCCACACAGGCGTGCACC
GGTAGAGGGCACAGGAGGCCAAGGGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGATACCTCCAGCCAGGCCTCTGTGGCCTCTGTTTCC
TTCTCCCTTTCTTGGCCCTCCTCTGCTCCTCCCCACACCCTGCAGGCAAAAGAAACCCCCAGCTTCCCCCCTCCCCGGGAGCCAGGTGGG
AAAAGTGGGTGTGATTTTTAGATTTTGTATTGTGGACTGATTTTGCCTCACATTAAAAACTCATCCCATGGCCAGGGCGGGCCACTGTGC

>93558_93558_1_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30136831_ENST00000335574_length(amino acids)=328AA_BP=81
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPEIINY
EFDTKDLVCLGLSSIVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDVFWVFGTNVMVTVAKSFEAPIKLVFPQ
DLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALA

--------------------------------------------------------------
>93558_93558_2_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30136831_ENST00000340852_length(transcript)=1785nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGAGATCATCAATTATGAATTTGACACCAAGGACCTGGTGTGCCTGGGCCTGAGC
AGCATCGTTGGCGTCTGGTACCTGCTGAGGAAGCACTGGATTGCCAACAACCTTTTTGGCCTGGCCTTCTCCCTTAATGGAGTAGAGCTC
CTGCACCTCAACAATGTCAGCACTGGCTGCATCCTGCTGGGCGGACTCTTCATCTACGATGTCTTCTGGGTATTTGGCACCAATGTGATG
GTGACAGTGGCCAAGTCCTTCGAGGCACCAATAAAATTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCC
ATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATCTTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACC
TACTTCTACACCAGCTTTGCAGCCTACATCTTCGGCCTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTC
CTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTCCTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGTTATGAGGAGTCA
AATCCTAAGGATCCAGCGGCAGTGACAGAATCCAAAGAGGGAACAGAGGCATCAGCATCGAAGGGGCTGGAGAAGAAAGAGAAATGATGC
AGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAGACAGATGGGGGCTGGGCCCACACAGGCGTGCACCGGTAGAGGGCACAGGAGGCCAAG
GGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGATACCTCCAGCCAGGCCTCTGTGGCCTCTGTTTCCTTCTCCCTTTCTTGGCCCTCCTC
TGCTCCTCCCCACACCCTGCAGGCAAAAGAAACCCCCAGCTTCCCCCCTCCCCGGGAGCCAGGTGGGAAAAGTGGGTGTGATTTTTAGAT

>93558_93558_2_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30136831_ENST00000340852_length(amino acids)=311AA_BP=81
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPEIINY
EFDTKDLVCLGLSSIVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDVFWVFGTNVMVTVAKSFEAPIKLVFPQ
DLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALA

--------------------------------------------------------------
>93558_93558_3_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30136831_ENST00000376127_length(transcript)=1634nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGAGATCATCAATTATGAATTTGACACCAAGGACCTGGTGTGCCTGGGCCTGAGC
AGCATCGTTGGCGTCTGGTACCTGCTGAGGAAGGTATTTGGCACCAATGTGATGGTGACAGTGGCCAAGTCCTTCGAGGCACCAATAAAA
TTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCCATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATC
TTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACCTACTTCTACACCAGCTTTGCAGCCTACATCTTCGGC
CTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTCCTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTC
CTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGTTATGAGGAGTCAAATCCTAAGGATCCAGCGGCAGTGACAGAATCCAAA
GAGGGAACAGAGGCATCAGCATCGAAGGGGCTGGAGAAGAAAGAGAAATGATGCAGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAGACA
GATGGGGGCTGGGCCCACACAGGCGTGCACCGGTAGAGGGCACAGGAGGCCAAGGGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGATAC
CTCCAGCCAGGCCTCTGTGGCCTCTGTTTCCTTCTCCCTTTCTTGGCCCTCCTCTGCTCCTCCCCACACCCTGCAGGCAAAAGAAACCCC
CAGCTTCCCCCCTCCCCGGGAGCCAGGTGGGAAAAGTGGGTGTGATTTTTAGATTTTGTATTGTGGACTGATTTTGCCTCACATTAAAAA

>93558_93558_3_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30136831_ENST00000376127_length(amino acids)=269AA_BP=81
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPEIINY
EFDTKDLVCLGLSSIVGVWYLLRKVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTH

--------------------------------------------------------------
>93558_93558_4_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30136831_ENST00000398174_length(transcript)=1932nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGAGATCATCAATTATGAATTTGACACCAAGGACCTGGTGTGCCTGGGCCTGAGC
AGCATCGTTGGCGTCTGGTACCTGCTGAGGAAGCACTGGATTGCCAACAACCTTTTTGGCCTGGCCTTCTCCCTTAATGGAGTAGAGCTC
CTGCACCTCAACAATGTCAGCACTGGCTGCATCCTGCTGGGCGGACTCTTCATCTACGATGTCTTCTGGGTATTTGGCACCAATGTGATG
GTGACAGTGGCCAAGTCCTTCGAGGCACCAATAAAATTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCC
ATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATCTTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACC
TACTTCTACACCAGCTTTGCAGCCTACATCTTCGGCCTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTC
CTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTCCTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGCTACGAGTCCTCG
GCGGAAATCCTGCCTCATACCCCGAGGCTCACCCACTTCCCCACAGTCTCGGGCTCCCCAGCCAGCCTGGCCGACTCCATGCAGCAGAAG
CTAGCTGGCCCTCGCCGCCGGCGCCCGCAGAATCCCAGCGCCATTTATGAGGAGTCAAATCCTAAGGATCCAGCGGCAGTGACAGAATCC
AAAGAGGGAACAGAGGCATCAGCATCGAAGGGGCTGGAGAAGAAAGAGAAATGATGCAGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAG
ACAGATGGGGGCTGGGCCCACACAGGCGTGCACCGGTAGAGGGCACAGGAGGCCAAGGGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGA
TACCTCCAGCCAGGCCTCTGTGGCCTCTGTTTCCTTCTCCCTTTCTTGGCCCTCCTCTGCTCCTCCCCACACCCTGCAGGCAAAAGAAAC
CCCCAGCTTCCCCCCTCCCCGGGAGCCAGGTGGGAAAAGTGGGTGTGATTTTTAGATTTTGTATTGTGGACTGATTTTGCCTCACATTAA

>93558_93558_4_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30136831_ENST00000398174_length(amino acids)=360AA_BP=81
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPEIINY
EFDTKDLVCLGLSSIVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDVFWVFGTNVMVTVAKSFEAPIKLVFPQ
DLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALA
KGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSMQQKLAGPRRRRPQNPSAIYEESNPKDPAAVTESKEGTEASASKGLEKKEK

--------------------------------------------------------------
>93558_93558_5_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30142549_ENST00000335574_length(transcript)=1718nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCC
ATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATCTTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACC
TACTTCTACACCAGCTTTGCAGCCTACATCTTCGGCCTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTC
CTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTCCTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGCTACGAGTCCTCG
GCGGAAATCCTGCCTCATACCCCGAGGCTCACCCACTTCCCCACAGTCTCGGGCTCCCCAGCCAGCCTGGCCGACTCCATGCAGCAGAAG
CTAGCTGGCCCTCGCCGCCGGCGCCCGCAGAATCCCAGCGCCATGTAATGCCCAGCGGGTGCCCACCTGCCCGCTTCCCCCTACTGCCCC
GGGGCCCAAGTTATGAGGAGTCAAATCCTAAGGATCCAGCGGCAGTGACAGAATCCAAAGAGGGAACAGAGGCATCAGCATCGAAGGGGC
TGGAGAAGAAAGAGAAATGATGCAGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAGACAGATGGGGGCTGGGCCCACACAGGCGTGCACC
GGTAGAGGGCACAGGAGGCCAAGGGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGATACCTCCAGCCAGGCCTCTGTGGCCTCTGTTTCC
TTCTCCCTTTCTTGGCCCTCCTCTGCTCCTCCCCACACCCTGCAGGCAAAAGAAACCCCCAGCTTCCCCCCTCCCCGGGAGCCAGGTGGG
AAAAGTGGGTGTGATTTTTAGATTTTGTATTGTGGACTGATTTTGCCTCACATTAAAAACTCATCCCATGGCCAGGGCGGGCCACTGTGC

>93558_93558_5_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30142549_ENST00000335574_length(amino acids)=238AA_BP=85
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVVFPQ
DLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALA

--------------------------------------------------------------
>93558_93558_6_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30142549_ENST00000340852_length(transcript)=1515nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCC
ATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATCTTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACC
TACTTCTACACCAGCTTTGCAGCCTACATCTTCGGCCTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTC
CTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTCCTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGTTATGAGGAGTCA
AATCCTAAGGATCCAGCGGCAGTGACAGAATCCAAAGAGGGAACAGAGGCATCAGCATCGAAGGGGCTGGAGAAGAAAGAGAAATGATGC
AGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAGACAGATGGGGGCTGGGCCCACACAGGCGTGCACCGGTAGAGGGCACAGGAGGCCAAG
GGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGATACCTCCAGCCAGGCCTCTGTGGCCTCTGTTTCCTTCTCCCTTTCTTGGCCCTCCTC
TGCTCCTCCCCACACCCTGCAGGCAAAAGAAACCCCCAGCTTCCCCCCTCCCCGGGAGCCAGGTGGGAAAAGTGGGTGTGATTTTTAGAT

>93558_93558_6_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30142549_ENST00000340852_length(amino acids)=221AA_BP=85
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVVFPQ
DLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALA

--------------------------------------------------------------
>93558_93558_7_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30142549_ENST00000376127_length(transcript)=1490nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCC
ATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATCTTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACC
TACTTCTACACCAGCTTTGCAGCCTACATCTTCGGCCTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTC
CTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTCCTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGTTATGAGGAGTCA
AATCCTAAGGATCCAGCGGCAGTGACAGAATCCAAAGAGGGAACAGAGGCATCAGCATCGAAGGGGCTGGAGAAGAAAGAGAAATGATGC
AGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAGACAGATGGGGGCTGGGCCCACACAGGCGTGCACCGGTAGAGGGCACAGGAGGCCAAG
GGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGATACCTCCAGCCAGGCCTCTGTGGCCTCTGTTTCCTTCTCCCTTTCTTGGCCCTCCTC
TGCTCCTCCCCACACCCTGCAGGCAAAAGAAACCCCCAGCTTCCCCCCTCCCCGGGAGCCAGGTGGGAAAAGTGGGTGTGATTTTTAGAT

>93558_93558_7_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30142549_ENST00000376127_length(amino acids)=221AA_BP=85
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVVFPQ
DLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALA

--------------------------------------------------------------
>93558_93558_8_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30142549_ENST00000398174_length(transcript)=1662nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCC
ATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATCTTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACC
TACTTCTACACCAGCTTTGCAGCCTACATCTTCGGCCTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTC
CTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTCCTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGCTACGAGTCCTCG
GCGGAAATCCTGCCTCATACCCCGAGGCTCACCCACTTCCCCACAGTCTCGGGCTCCCCAGCCAGCCTGGCCGACTCCATGCAGCAGAAG
CTAGCTGGCCCTCGCCGCCGGCGCCCGCAGAATCCCAGCGCCATTTATGAGGAGTCAAATCCTAAGGATCCAGCGGCAGTGACAGAATCC
AAAGAGGGAACAGAGGCATCAGCATCGAAGGGGCTGGAGAAGAAAGAGAAATGATGCAGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAG
ACAGATGGGGGCTGGGCCCACACAGGCGTGCACCGGTAGAGGGCACAGGAGGCCAAGGGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGA
TACCTCCAGCCAGGCCTCTGTGGCCTCTGTTTCCTTCTCCCTTTCTTGGCCCTCCTCTGCTCCTCCCCACACCCTGCAGGCAAAAGAAAC
CCCCAGCTTCCCCCCTCCCCGGGAGCCAGGTGGGAAAAGTGGGTGTGATTTTTAGATTTTGTATTGTGGACTGATTTTGCCTCACATTAA

>93558_93558_8_TPX2-HM13_TPX2_chr20_30347982_ENST00000300403_HM13_chr20_30142549_ENST00000398174_length(amino acids)=270AA_BP=85
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVVFPQ
DLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALA
KGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSMQQKLAGPRRRRPQNPSAIYEESNPKDPAAVTESKEGTEASASKGLEKKEK

--------------------------------------------------------------
>93558_93558_9_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30136831_ENST00000335574_length(transcript)=1988nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGAGATCATCAATTATGAATTTGACACCAAGGACCTGGTGTGCCTGGGCCTGAGC
AGCATCGTTGGCGTCTGGTACCTGCTGAGGAAGCACTGGATTGCCAACAACCTTTTTGGCCTGGCCTTCTCCCTTAATGGAGTAGAGCTC
CTGCACCTCAACAATGTCAGCACTGGCTGCATCCTGCTGGGCGGACTCTTCATCTACGATGTCTTCTGGGTATTTGGCACCAATGTGATG
GTGACAGTGGCCAAGTCCTTCGAGGCACCAATAAAATTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCC
ATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATCTTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACC
TACTTCTACACCAGCTTTGCAGCCTACATCTTCGGCCTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTC
CTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTCCTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGCTACGAGTCCTCG
GCGGAAATCCTGCCTCATACCCCGAGGCTCACCCACTTCCCCACAGTCTCGGGCTCCCCAGCCAGCCTGGCCGACTCCATGCAGCAGAAG
CTAGCTGGCCCTCGCCGCCGGCGCCCGCAGAATCCCAGCGCCATGTAATGCCCAGCGGGTGCCCACCTGCCCGCTTCCCCCTACTGCCCC
GGGGCCCAAGTTATGAGGAGTCAAATCCTAAGGATCCAGCGGCAGTGACAGAATCCAAAGAGGGAACAGAGGCATCAGCATCGAAGGGGC
TGGAGAAGAAAGAGAAATGATGCAGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAGACAGATGGGGGCTGGGCCCACACAGGCGTGCACC
GGTAGAGGGCACAGGAGGCCAAGGGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGATACCTCCAGCCAGGCCTCTGTGGCCTCTGTTTCC
TTCTCCCTTTCTTGGCCCTCCTCTGCTCCTCCCCACACCCTGCAGGCAAAAGAAACCCCCAGCTTCCCCCCTCCCCGGGAGCCAGGTGGG
AAAAGTGGGTGTGATTTTTAGATTTTGTATTGTGGACTGATTTTGCCTCACATTAAAAACTCATCCCATGGCCAGGGCGGGCCACTGTGC

>93558_93558_9_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30136831_ENST00000335574_length(amino acids)=328AA_BP=81
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPEIINY
EFDTKDLVCLGLSSIVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDVFWVFGTNVMVTVAKSFEAPIKLVFPQ
DLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALA

--------------------------------------------------------------
>93558_93558_10_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30136831_ENST00000340852_length(transcript)=1785nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGAGATCATCAATTATGAATTTGACACCAAGGACCTGGTGTGCCTGGGCCTGAGC
AGCATCGTTGGCGTCTGGTACCTGCTGAGGAAGCACTGGATTGCCAACAACCTTTTTGGCCTGGCCTTCTCCCTTAATGGAGTAGAGCTC
CTGCACCTCAACAATGTCAGCACTGGCTGCATCCTGCTGGGCGGACTCTTCATCTACGATGTCTTCTGGGTATTTGGCACCAATGTGATG
GTGACAGTGGCCAAGTCCTTCGAGGCACCAATAAAATTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCC
ATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATCTTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACC
TACTTCTACACCAGCTTTGCAGCCTACATCTTCGGCCTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTC
CTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTCCTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGTTATGAGGAGTCA
AATCCTAAGGATCCAGCGGCAGTGACAGAATCCAAAGAGGGAACAGAGGCATCAGCATCGAAGGGGCTGGAGAAGAAAGAGAAATGATGC
AGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAGACAGATGGGGGCTGGGCCCACACAGGCGTGCACCGGTAGAGGGCACAGGAGGCCAAG
GGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGATACCTCCAGCCAGGCCTCTGTGGCCTCTGTTTCCTTCTCCCTTTCTTGGCCCTCCTC
TGCTCCTCCCCACACCCTGCAGGCAAAAGAAACCCCCAGCTTCCCCCCTCCCCGGGAGCCAGGTGGGAAAAGTGGGTGTGATTTTTAGAT

>93558_93558_10_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30136831_ENST00000340852_length(amino acids)=311AA_BP=81
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPEIINY
EFDTKDLVCLGLSSIVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDVFWVFGTNVMVTVAKSFEAPIKLVFPQ
DLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALA

--------------------------------------------------------------
>93558_93558_11_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30136831_ENST00000376127_length(transcript)=1634nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGAGATCATCAATTATGAATTTGACACCAAGGACCTGGTGTGCCTGGGCCTGAGC
AGCATCGTTGGCGTCTGGTACCTGCTGAGGAAGGTATTTGGCACCAATGTGATGGTGACAGTGGCCAAGTCCTTCGAGGCACCAATAAAA
TTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCCATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATC
TTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACCTACTTCTACACCAGCTTTGCAGCCTACATCTTCGGC
CTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTCCTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTC
CTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGTTATGAGGAGTCAAATCCTAAGGATCCAGCGGCAGTGACAGAATCCAAA
GAGGGAACAGAGGCATCAGCATCGAAGGGGCTGGAGAAGAAAGAGAAATGATGCAGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAGACA
GATGGGGGCTGGGCCCACACAGGCGTGCACCGGTAGAGGGCACAGGAGGCCAAGGGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGATAC
CTCCAGCCAGGCCTCTGTGGCCTCTGTTTCCTTCTCCCTTTCTTGGCCCTCCTCTGCTCCTCCCCACACCCTGCAGGCAAAAGAAACCCC
CAGCTTCCCCCCTCCCCGGGAGCCAGGTGGGAAAAGTGGGTGTGATTTTTAGATTTTGTATTGTGGACTGATTTTGCCTCACATTAAAAA

>93558_93558_11_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30136831_ENST00000376127_length(amino acids)=269AA_BP=81
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPEIINY
EFDTKDLVCLGLSSIVGVWYLLRKVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTH

--------------------------------------------------------------
>93558_93558_12_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30136831_ENST00000398174_length(transcript)=1932nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGAGATCATCAATTATGAATTTGACACCAAGGACCTGGTGTGCCTGGGCCTGAGC
AGCATCGTTGGCGTCTGGTACCTGCTGAGGAAGCACTGGATTGCCAACAACCTTTTTGGCCTGGCCTTCTCCCTTAATGGAGTAGAGCTC
CTGCACCTCAACAATGTCAGCACTGGCTGCATCCTGCTGGGCGGACTCTTCATCTACGATGTCTTCTGGGTATTTGGCACCAATGTGATG
GTGACAGTGGCCAAGTCCTTCGAGGCACCAATAAAATTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCC
ATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATCTTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACC
TACTTCTACACCAGCTTTGCAGCCTACATCTTCGGCCTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTC
CTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTCCTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGCTACGAGTCCTCG
GCGGAAATCCTGCCTCATACCCCGAGGCTCACCCACTTCCCCACAGTCTCGGGCTCCCCAGCCAGCCTGGCCGACTCCATGCAGCAGAAG
CTAGCTGGCCCTCGCCGCCGGCGCCCGCAGAATCCCAGCGCCATTTATGAGGAGTCAAATCCTAAGGATCCAGCGGCAGTGACAGAATCC
AAAGAGGGAACAGAGGCATCAGCATCGAAGGGGCTGGAGAAGAAAGAGAAATGATGCAGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAG
ACAGATGGGGGCTGGGCCCACACAGGCGTGCACCGGTAGAGGGCACAGGAGGCCAAGGGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGA
TACCTCCAGCCAGGCCTCTGTGGCCTCTGTTTCCTTCTCCCTTTCTTGGCCCTCCTCTGCTCCTCCCCACACCCTGCAGGCAAAAGAAAC
CCCCAGCTTCCCCCCTCCCCGGGAGCCAGGTGGGAAAAGTGGGTGTGATTTTTAGATTTTGTATTGTGGACTGATTTTGCCTCACATTAA

>93558_93558_12_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30136831_ENST00000398174_length(amino acids)=360AA_BP=81
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPEIINY
EFDTKDLVCLGLSSIVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDVFWVFGTNVMVTVAKSFEAPIKLVFPQ
DLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALA
KGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSMQQKLAGPRRRRPQNPSAIYEESNPKDPAAVTESKEGTEASASKGLEKKEK

--------------------------------------------------------------
>93558_93558_13_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30142549_ENST00000335574_length(transcript)=1718nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCC
ATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATCTTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACC
TACTTCTACACCAGCTTTGCAGCCTACATCTTCGGCCTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTC
CTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTCCTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGCTACGAGTCCTCG
GCGGAAATCCTGCCTCATACCCCGAGGCTCACCCACTTCCCCACAGTCTCGGGCTCCCCAGCCAGCCTGGCCGACTCCATGCAGCAGAAG
CTAGCTGGCCCTCGCCGCCGGCGCCCGCAGAATCCCAGCGCCATGTAATGCCCAGCGGGTGCCCACCTGCCCGCTTCCCCCTACTGCCCC
GGGGCCCAAGTTATGAGGAGTCAAATCCTAAGGATCCAGCGGCAGTGACAGAATCCAAAGAGGGAACAGAGGCATCAGCATCGAAGGGGC
TGGAGAAGAAAGAGAAATGATGCAGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAGACAGATGGGGGCTGGGCCCACACAGGCGTGCACC
GGTAGAGGGCACAGGAGGCCAAGGGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGATACCTCCAGCCAGGCCTCTGTGGCCTCTGTTTCC
TTCTCCCTTTCTTGGCCCTCCTCTGCTCCTCCCCACACCCTGCAGGCAAAAGAAACCCCCAGCTTCCCCCCTCCCCGGGAGCCAGGTGGG
AAAAGTGGGTGTGATTTTTAGATTTTGTATTGTGGACTGATTTTGCCTCACATTAAAAACTCATCCCATGGCCAGGGCGGGCCACTGTGC

>93558_93558_13_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30142549_ENST00000335574_length(amino acids)=238AA_BP=85
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVVFPQ
DLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALA

--------------------------------------------------------------
>93558_93558_14_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30142549_ENST00000340852_length(transcript)=1515nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCC
ATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATCTTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACC
TACTTCTACACCAGCTTTGCAGCCTACATCTTCGGCCTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTC
CTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTCCTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGTTATGAGGAGTCA
AATCCTAAGGATCCAGCGGCAGTGACAGAATCCAAAGAGGGAACAGAGGCATCAGCATCGAAGGGGCTGGAGAAGAAAGAGAAATGATGC
AGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAGACAGATGGGGGCTGGGCCCACACAGGCGTGCACCGGTAGAGGGCACAGGAGGCCAAG
GGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGATACCTCCAGCCAGGCCTCTGTGGCCTCTGTTTCCTTCTCCCTTTCTTGGCCCTCCTC
TGCTCCTCCCCACACCCTGCAGGCAAAAGAAACCCCCAGCTTCCCCCCTCCCCGGGAGCCAGGTGGGAAAAGTGGGTGTGATTTTTAGAT

>93558_93558_14_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30142549_ENST00000340852_length(amino acids)=221AA_BP=85
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVVFPQ
DLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALA

--------------------------------------------------------------
>93558_93558_15_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30142549_ENST00000376127_length(transcript)=1490nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCC
ATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATCTTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACC
TACTTCTACACCAGCTTTGCAGCCTACATCTTCGGCCTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTC
CTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTCCTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGTTATGAGGAGTCA
AATCCTAAGGATCCAGCGGCAGTGACAGAATCCAAAGAGGGAACAGAGGCATCAGCATCGAAGGGGCTGGAGAAGAAAGAGAAATGATGC
AGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAGACAGATGGGGGCTGGGCCCACACAGGCGTGCACCGGTAGAGGGCACAGGAGGCCAAG
GGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGATACCTCCAGCCAGGCCTCTGTGGCCTCTGTTTCCTTCTCCCTTTCTTGGCCCTCCTC
TGCTCCTCCCCACACCCTGCAGGCAAAAGAAACCCCCAGCTTCCCCCCTCCCCGGGAGCCAGGTGGGAAAAGTGGGTGTGATTTTTAGAT

>93558_93558_15_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30142549_ENST00000376127_length(amino acids)=221AA_BP=85
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVVFPQ
DLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALA

--------------------------------------------------------------
>93558_93558_16_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30142549_ENST00000398174_length(transcript)=1662nt_BP=757nt
TCAAAATTTCAACGATACTGAATGAGTCCCGCGGCGGGTTGGCTCGCGCTTCGTTGTCAGATCTGAGGCGAGGCTAGGTGAGCCGTGGGA
AGAAAAGAGGGAGCAGCTAGGGCGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGC
GCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGCGGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCT
CTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGAT
ACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTA
AACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTT
AAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGAGATACTCAAAACATAGATTCATGG
TTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCT
AATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGTGGTGTTTCCCCAGGATCTGCTGGAGAAAGGCCTCGAAGCAAACAACTTTGCC
ATGCTGGGACTTGGAGATGTCGTCATTCCAGGGATCTTCATTGCCTTGCTGCTGCGCTTTGACATCAGCTTGAAGAAGAATACCCACACC
TACTTCTACACCAGCTTTGCAGCCTACATCTTCGGCCTGGGCCTTACCATCTTCATCATGCACATCTTCAAGCATGCTCAGCCTGCCCTC
CTATACCTGGTCCCCGCCTGCATCGGTTTTCCTGTCCTGGTGGCGCTGGCCAAGGGAGAAGTGACAGAGATGTTCAGCTACGAGTCCTCG
GCGGAAATCCTGCCTCATACCCCGAGGCTCACCCACTTCCCCACAGTCTCGGGCTCCCCAGCCAGCCTGGCCGACTCCATGCAGCAGAAG
CTAGCTGGCCCTCGCCGCCGGCGCCCGCAGAATCCCAGCGCCATTTATGAGGAGTCAAATCCTAAGGATCCAGCGGCAGTGACAGAATCC
AAAGAGGGAACAGAGGCATCAGCATCGAAGGGGCTGGAGAAGAAAGAGAAATGATGCAGCTGGTGCCCGAGCCTCTCAGGGCCAGACCAG
ACAGATGGGGGCTGGGCCCACACAGGCGTGCACCGGTAGAGGGCACAGGAGGCCAAGGGCAGCTCCAGGACAGGGCAGGGGGCAGCAGGA
TACCTCCAGCCAGGCCTCTGTGGCCTCTGTTTCCTTCTCCCTTTCTTGGCCCTCCTCTGCTCCTCCCCACACCCTGCAGGCAAAAGAAAC
CCCCAGCTTCCCCCCTCCCCGGGAGCCAGGTGGGAAAAGTGGGTGTGATTTTTAGATTTTGTATTGTGGACTGATTTTGCCTCACATTAA

>93558_93558_16_TPX2-HM13_TPX2_chr20_30347982_ENST00000340513_HM13_chr20_30142549_ENST00000398174_length(amino acids)=270AA_BP=85
MLFCVKWETMSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVVFPQ
DLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALA
KGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSMQQKLAGPRRRRPQNPSAIYEESNPKDPAAVTESKEGTEASASKGLEKKEK

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Fusion Gene PPI Analysis for TPX2-HM13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TPX2-HM13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TPX2-HM13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource